Kit for use of microneedle sheet and cosmetic method

Abstract

The present invention relates to a kit comprising: at least one microneedle sheet (1) comprising a substrate layer and a plurality of microneedles on the substrate layer, the microneedles comprising at least one water-soluble or water-dispersible polymer; and a device comprising an applicator (2-3), a container (2-1) and a valve, the applicator (2-3) comprising an application surface, the container (2-1) containing a cosmetic composition, wherein the microneedle sheet (1) can be attached to the applicator (2-3) by attaching the substrate layer of the microneedle sheet to the application surface, the applicator (2-3), the container (2-1) and the valve being configured to supply the cosmetic composition onto the microneedle sheet (1) via the valve. The kit according to the present invention can prevent the reuse of the microneedles (1) and can apply the cosmetic in an easy and hygienic manner.

Description

Technical Field

[0001] The present invention relates to a kit comprising at least one microneedle sheet containing multiple microneedles, and a cosmetic method using the microneedle sheet for keratinous substances such as skin, lips and scalp. Background Technology

[0002] The stratum corneum (SC) forms the primary barrier against exogenous substances, including those with low molecular weight molecules. Generally, exogenous substances penetrating the skin must diffuse through the highly organized intercellular lipid bilayer of the SC. These lipophilic intercellular microchannels are the main pathway by which exogenous substances passively diffuse across the SC barrier along the concentration gradient between the delivery carrier and the SC. Some exogenous substances have difficulty penetrating the skin.

[0003] To deliver exogenous substances deeper into the skin, injections can be performed using conventional needles. However, such injections can be painful and require a professional, such as a doctor, to administer. Therefore, injections using conventional needles are not commonly used for cosmetic purposes.

[0004] The concept of using microstructured devices with multiple microneedles to penetrate the stratum corneum (SC) barrier was first proposed in the 1970s. Various devices incorporating solid microneedles have been developed to create systems that pierce the stratum corneum, leaving tiny pores, and enabling subsequent inward drug delivery or outward migration of interstitial fluid. The production of solid microprotrusions and microneedle arrays using, for example, silicon or insoluble polymers has been described in the art, e.g., WO 2009 / 040548 and US-A-2015 / 0141910.

[0005] However, these insoluble microneedles remain sharp and intact after application, which poses a high risk of cross-contamination due to repeated use of the microneedles.

[0006] Furthermore, if cosmetics are used in conjunction with the use of such systems currently known in the art, it is necessary to apply the cosmetics to the skin by hand, which may be difficult and unhygienic. Summary of the Invention

[0007] The purpose of this invention is to provide a kit that prevents the reuse of microneedles and allows for the easy and hygienic application of cosmetics, as well as a cosmetic method that can use the kit.

[0008] The above objectives can be achieved through a kit, preferably a cosmetic kit for keratin substances, and more preferably a cosmetic kit for skin, lips, or scalp, the kit comprising:

[0009] At least one microneedle sheet comprising a substrate layer and a plurality of microneedles on the substrate layer, the microneedles comprising at least one water-soluble or water-dispersible polymer;

[0010] and

[0011] At least one device comprising at least one applicator, at least one container, and at least one valve, the applicator including at least one application surface, and the container containing at least one cosmetic composition.

[0012] in

[0013] By attaching the substrate layer of the microneedle sheet to the application surface of the applicator, the microneedle sheet can be connected to the applicator.

[0014] The applicator, container, and valve are configured to supply the cosmetic composition via the valve to microneedles connected to the applicator.

[0015] The valve controls the supply of cosmetic composition to the microneedles attached to the applicator.

[0016] The substrate layer of the preferred microneedle sheet can be separated from the application surface of the applicator after being connected to the application surface of the applicator.

[0017] The microneedle sheet may include at least one substrate layer that can be fixed on a substrate layer.

[0018] The microneedle sheet may include at least one adhesive layer that can be fixed to a substrate or base layer (if present).

[0019] The microneedle sheet may include at least one anti-adhesive layer that may be located on the adhesive layer.

[0020] The microneedles may have a height of 50 to 1000 micrometers, preferably 100 to 750 micrometers, and more preferably 150 to 500 micrometers.

[0021] The application surface of the applicator may be curved. The applicator may include at least one cylindrical roller having a curved end face, and the curved end face of the cylindrical roller may constitute the application surface.

[0022] The kit according to the invention may further include at least one housing, wherein the housing is capable of storing microneedle sheets.

[0023] The housing may include at least one soft and / or porous material, preferably selected from sponges, woven or nonwoven fabrics, and combinations thereof.

[0024] The preferred valve is a gate valve.

[0025] The preferred cosmetic composition contains at least one cosmetic active ingredient.

[0026] The present invention also relates to a cosmetic method for use with keratinous materials such as skin, lips, and scalp, comprising the following steps:

[0027] At least one microneedle sheet is connected to at least one applicator having at least one application surface.

[0028] in

[0029] The microneedle sheet comprises a substrate layer and a plurality of microneedles on the substrate layer, the microneedles comprising at least one water-soluble or water-dispersible polymer.

[0030] and

[0031] The applicator is included in at least one device comprising at least one container and at least one valve, the container containing at least one cosmetic composition.

[0032] It is achieved by attaching the substrate layer of the microneedle sheet to the application surface of the applicator;

[0033] as well as

[0034] Apply the applicator to the keratin material so that the microneedles come into contact with the keratin material.

[0035] in

[0036] Configure an applicator, container, and valve to supply the cosmetic composition via the valve to microneedles connected to the applicator.

[0037] The valve controls the supply of the cosmetic composition to the microneedles connected to the applicator, and

[0038] During the step of applying an applicator to keratinous material, a cosmetic composition is supplied onto microneedle sheets.

[0039] The cosmetic method according to the invention may further include the step of applying an applicator to a keratin substance without supplying a cosmetic composition to the microneedles on the application surface of the applicator. Brief description of the attached diagram

[0041] Figure 1 A cross-sectional view of an example of a microneedle sheet intended for use in the present invention is shown.

[0042] Figure 2 A perspective view showing an example of an apparatus comprising at least one applicator, at least one container, and at least one valve.

[0043] Figures 3A and 3B show schematic diagrams of the device in the "open" and "closed" positions of the valve.

[0044] Figure 4 A perspective view of a device with microneedles is shown.

[0045] Figure 5 A perspective view showing how to use a device with microneedles.

[0046] Figure 6 A cross-sectional view of an example of a housing that can be used in this invention is shown.

[0047] Best mode for carrying out the invention

[0048] After diligent research, the inventors have discovered the possibility of providing a kit that prevents the reuse of microneedles and allows for the easy and hygienic application of cosmetics.

[0049] This invention uses disposable microneedle sheets with deformable, water-soluble or water-dispersible microneedles instead of reusable microneedle sheets with insoluble microneedles. Therefore, upon first use, the microneedles can deform, for example, by dissolving or absorbing into cosmetics containing and / or on keratin. Consequently, used microneedle sheets need to be replaced with new ones after a single use. This prevents the reuse of microneedles.

[0050] The present invention also uses a device for supplying a controlled amount of cosmetic composition onto a microneedle sheet. The cosmetic composition supplied onto the microneedle sheet can be applied to keratinous material via the surface of the microneedle sheet. Therefore, the cosmetic composition can be applied to keratinous material in an easy and hygienic manner.

[0051] Because cosmetic compositions can be applied to keratinous substances such as skin, lips, and scalp in combination with microneedles, the cosmetic composition can penetrate into the keratinous substance relatively easily through the pores or openings formed by the microneedles of the microneedles compared to not using microneedles. Therefore, compared to not using microneedles, the present invention allows cosmetic compositions to penetrate much deeper into keratinous substances and can deliver relatively large quantities of cosmetic composition into the keratinous substance.

[0052] Therefore, one aspect of the invention is a kit comprising:

[0053] At least one microneedle sheet comprising a substrate layer and a plurality of microneedles on the substrate layer, the microneedles comprising at least one water-soluble or water-dispersible polymer;

[0054] and

[0055] At least one device comprising at least one applicator, at least one container, and at least one valve, the applicator including at least one application surface, and the container containing at least one cosmetic composition.

[0056] in

[0057] By attaching the substrate layer of the microneedle sheet to the application surface of the applicator, the microneedle sheet can be connected to the applicator.

[0058] The applicator, container, and valve are configured to supply the cosmetic composition via the valve to microneedles connected to the applicator.

[0059] The valve controls the supply of cosmetic composition to the microneedles attached to the applicator.

[0060] Another aspect of the present invention is a cosmetic method for use with keratinous materials such as skin, lips, and scalp, comprising the following steps:

[0061] At least one microneedle sheet is connected to at least one applicator having at least one application surface.

[0062] in

[0063] The microneedle sheet comprises a substrate layer and a plurality of microneedles on the substrate layer, the microneedles comprising at least one water-soluble or water-dispersible polymer.

[0064] and

[0065] The applicator is included in at least one device comprising at least one container and at least one valve, the container containing at least one cosmetic composition.

[0066] It is achieved by attaching the substrate layer of the microneedle sheet to the application surface of the applicator;

[0067] as well as

[0068] Apply the applicator to the keratin material so that the microneedles come into contact with the keratin material.

[0069] in

[0070] Configure an applicator, container, and valve to supply the cosmetic composition via the valve to microneedles connected to the applicator.

[0071] The valve controls the supply of the cosmetic composition to the microneedles connected to the applicator, and

[0072] During the step of applying an applicator to keratinous material, a cosmetic composition is supplied onto microneedle sheets.

[0073] The kits and cosmetic methods according to the invention prevent the reuse of microneedles and allow for the application of cosmetics in an easy and hygienic manner.

[0074] If the applicator is in the form of a cylindrical roller, a cosmetic composition can be continuously and quantitatively applied to keratinous substances such as skin, lips, and scalp by rolling the applicator over them. Furthermore, by rolling the applicator over keratinous substances such as skin, lips, and scalp, a uniform cosmetic film can be easily formed on the keratinous substance using the cosmetic composition.

[0075] According to the present invention, the microneedle sheet is separate from the applicator when not in use. When in use, the microneedle sheet can be attached to the applicator. Therefore, the user can easily store the applicator without damaging the microneedles.

[0076] Preferably, the substrate layer of the microneedle sheet can be detached from the application surface of the applicator after being attached to it. In this case, the applicator can be reused by replacing the microneedle sheet. The replacement of the microneedle sheet can be performed by the user.

[0077] If the kit according to the invention further includes at least one housing capable of storing microneedle sheets, it is easier to store the microneedle sheets without damaging the microneedles.

[0078] Because microneedling does not cause any pain, this invention provides a painless cosmetic treatment. Therefore, the kits according to the invention are convenient for use in cosmetic or non-therapeutic treatments.

[0079] The kits and cosmetic methods according to the present invention will be described in detail below.

[0080] [Kit]

[0081] The kits according to the invention, preferably cosmetic kits for keratin substances, and more preferably cosmetic kits for skin, lips, or scalp, comprise:

[0082] At least one microneedle sheet comprising a substrate layer and a plurality of microneedles on the substrate layer, the microneedles comprising at least one water-soluble or water-dispersible polymer;

[0083] and

[0084] At least one device comprising at least one applicator, at least one container, and at least one valve, the applicator including at least one application surface, and the container containing at least one cosmetic composition.

[0085] in

[0086] By attaching the substrate layer of the microneedle sheet to the application surface of the applicator, the microneedle sheet can be connected to the applicator.

[0087] The applicator, container, and valve are configured to supply the cosmetic composition via the valve to microneedles connected to the applicator.

[0088] The valve controls the supply of cosmetic composition to the microneedles attached to the applicator.

[0089] The kit according to the invention can be used for cosmetic treatments of keratin substances.

[0090] {Microneedle Patch}

[0091] The microneedle sheet intended for use in the kit according to the invention comprises a substrate layer and a plurality of microneedles on the substrate layer, wherein the microneedles contain at least one water-soluble or water-dispersible polymer.

[0092] The microneedle sheet intended for use in this invention can be connected to the applicator of the device, which will be explained below.

[0093] The microneedle pads intended for use in this invention are disposable. After one use, the microneedle pad can be replaced with a new one.

[0094] (microneedling)

[0095] The microneedle sheet intended for use in this invention comprises a plurality of microneedles.

[0096] Microneedles are present on the surface of the substrate. Microneedles may be present on 50% or more, preferably 70% or more, and more preferably 90% or more of the surface of the substrate.

[0097] Preferably, the microneedles are present on one surface of the substrate layer.

[0098] Preferably, the microneedles of the microneedle sheet intended for use in the present invention are designed to penetrate or enter the stratum corneum of the skin (especially facial skin) and the lips or scalp.

[0099] Microneedles can be any suitable size and shape to pierce the stratum corneum. Preferably, microneedles are designed to pierce and penetrate the stratum corneum. Microneedles may be able to create openings within the stratum corneum.

[0100] If necessary, the height of the microneedles can be adjusted to allow penetration of the epidermis and / or dermis, preferably the upper dermis, and more preferably the lower dermis.

[0101] The shape of the microneedle is not limited, as long as it is a "needle". It will be apparent to those skilled in the art that the microneedles used in this invention can take any reasonable shape, including but not limited to cones, rods, and / or pillars. Therefore, the microneedle may have the same diameter at the tip as at the base, or its diameter may gradually taper from the base to the tip.

[0102] For example, the microneedle can be shaped like a triangular pyramid, a square pyramid, or a pentagonal pyramid. Alternatively, the microneedle can be cylindrical, preferably having a tip that can be formed by diagonally cutting the cylinder.

[0103] The cross-section of the microneedles can take any geometric shape, including circular, triangular, square, rectangular, polyhedral, regular or irregular shapes, etc. In an embodiment, a group of microneedles can take the form of hollow microcapillaries.

[0104] Therefore, "microneedles" are mentioned as a class of micro-protrusions or micro-projections currently in use. Those skilled in the art will understand that, in many cases, the same inventive principles apply to the use of other micro-protrusions or micro-projections for skin penetration. Other micro-protrusions or micro-projections may include, for example, the microblades described in U.S. Patent No. 6,219,574 and Canadian Patent Application No. 2,226,718, and the bladed microneedles described in U.S. Patent No. 6,652,478.

[0105] The height or length of the microneedles intended for use in the microneedle sheet of the present invention can be 50 to 1000 micrometers, preferably 100 to 750 micrometers, and more preferably 150 to 500 micrometers.

[0106] According to one embodiment of the present invention, the microneedles are cone-shaped.

[0107] A cone may include a distal end (e.g., a tip) and a base. The base may be circular or oval in shape.

[0108] The height or length of the cone of the microneedle in the microneedle sheet intended for use in the present invention may be 50 to 1000 micrometers, preferably 100 to 750 micrometers, and more preferably 150 to 500 micrometers.

[0109] The base of the cone of the microneedle intended for use in the microneedle sheet of the present invention may have a diameter or width of 50 to 350 micrometers, preferably 100 to 300 micrometers, and more preferably 150 to 250 micrometers. If the base of the cone of the microneedle intended for use in the microneedle sheet of the present invention is oval or elliptical, then the length of the major axis or the width of the oval shape may be 50 to 350 micrometers, preferably 100 to 300 micrometers, and more preferably 150 to 250 micrometers.

[0110] The microneedles may have an aspect ratio (length / width at the base) of at least about 3:1, at least about 2:1, or at least about 1:1. The ratio of the height of the cone to the diameter of the base of the cone may be 1 or greater, preferably 1.5 or greater, and more preferably 2.0 or greater.

[0111] Preferably, when less than 50.0 N / cm is applied along the length of the microneedle. 2 For example, less than 20.0 N / cm 2 For example, less than 10 N / cm 2 When the insertion pressure is applied, the microneedle will not break due to the force.

[0112] It is also preferred that the microneedle sheet to be used in the present invention, in particular the microneedles of the microneedle sheet have a Young's modulus of 50 N / mm or higher, preferably 55 N / mm or higher, and more preferably 60 N / mm or higher.

[0113] The microneedles are preferably capable of penetrating keratinous materials (such as skin, lips, and scalp) to a depth of 200 micrometers or less, preferably 180 micrometers or less, and more preferably 160 micrometers or less.

[0114] Microneedles are soluble. "Soluble" means that microneedles can dissolve (decompose or disintegrate) into cosmetic compositions that preferably contain water, and / or can be dissolved in keratinous substances such as skin, lips, and scalp by means of, for example, natural moisturizing factors or internal / external moisture.

[0115] The microneedles intended for use in the microneedle sheet of the present invention may comprise at least one water-soluble or water-dispersible polymer. Here, the terms "water-soluble" and "water-dispersible" respectively mean soluble and dispersible upon contact with water. A single water-soluble or water-dispersible polymer may be used. Two or more water-soluble or water-dispersible polymers may be used in combination.

[0116] Preferably, the water-soluble or water-dispersible polymer is soluble or dispersible in the skin, lips, or scalp. Therefore, in one embodiment of the invention, the water-soluble or water-dispersible polymer can dissolve or disperse after insertion into keratinous substances such as skin, lips, and scalp. Due to the solubility or dispersibility of the polymer, the microneedles intended for use in the microneedle sheet of the invention can effectively release one or more reagents (if present) from the microneedles. Optional external water, combined with the application of the microneedle sheet, can be used to accelerate the dissolution or dispersion of the microneedles.

[0117] Preferred water-soluble or water-dispersible polymers can dissolve in keratinous substances such as the surface layer of skin, lips, and scalp.

[0118] Water-soluble or water-dispersible polymers may be selected from hyaluronic acid (especially lower molecular weight hyaluronic acid), monosaccharides, disaccharides, oligosaccharides, polysaccharides (including their derivatives, such as hydroxymethyl cellulose), dextrin, dextran, polyethylene glycol, polyvinyl alcohol, poly(methyl vinyl ether / maleic anhydride), polyvinylpyrrolidone, poly(methyl vinyl ether / maleic acid) (PMVE / MA) and its esters, poly(methyl vinyl ether / maleic anhydride) (PMVE / MAH), their salts, and mixtures thereof.

[0119] Water-soluble or water-dispersible polymers may have a molecular weight of 10,000 to 200,000 Daltons, preferably 30,000 to 150,000 Daltons, and more preferably 50,000 to 100,000 Daltons.

[0120] Low molecular weight hyaluronic acid may have a molecular weight of 100 kDa or less, preferably 70 kDa or less, and more preferably 50 kDa or less.

[0121] Polyvinylpyrrolidone may have a molecular weight between 1 kDa and 300 kDa, preferably between 5 kDa and 200 kDa, and more preferably between 7 kDa and 100 kDa.

[0122] Poly(methyl vinyl ether / maleic acid) (PMVE / MA) and its esters and poly(methyl vinyl ether / maleic anhydride) (PMVE / MAH) are known to be Gantrez-type polymers.

[0123] The amount of water-soluble or water-dispersible polymer in the microneedles of the microneedles intended for use in the microneedle sheet of the present invention (based on solids) relative to the total weight of the microneedles can be 50% by weight or more, preferably 60% by weight or more, and more preferably 70% by weight or more. The amount of water-soluble or water-dispersible polymer in the microneedles of the microneedles of the microneedles intended for use in the present invention (based on solids) relative to the total weight of the microneedles can be 100% by weight or less, preferably 90% by weight or less, and more preferably 80% by weight or less. Therefore, the amount of water-soluble or water-dispersible polymer in the microneedles of the microneedles of the microneedles intended for use in the present invention (based on solids) relative to the total weight of the microneedles can be from 50% by weight to 100% by weight, preferably 60% by weight to 90% by weight, and more preferably 70% by weight to 80% by weight.

[0124] The microneedles intended for use in the microneedle sheets of the present invention may comprise at least one material that is swellable, more preferably water-swellable, and even more preferably swellable in keratinous substances such as skin, lips, and scalp. The aforementioned material may be a swellable, more preferably water-swellable, and even more preferably swellable in keratinous substances polymer. Here, the term "water-swellable" means swellable upon contact with water. The aforementioned swellable material or polymer may have high swellability, such that it swells to at least 10 times more, preferably at least 20 times, more preferably at least 30 times, even more preferably at least 40 times, and most preferably about 45-55 times, in physiological saline or phosphate-buffered saline solution during a 1-hour in vitro culture.

[0125] Preferably, at least the distal portion of the microneedle swells upon insertion into the keratin material, more preferably within 1 hour, and even more preferably within 24 hours after insertion into the keratin material, swelling to at least twice its original size.

[0126] The aforementioned swellable material, preferably the aforementioned swellable polymer, possesses high viscoelasticity, enabling it to form a gel after in vitro culture in physiological saline or phosphate-buffered saline. In dynamic frequency scanning tests using a rheometer, even at low frequencies (0.01 Hz), the gel exhibits a high elastic modulus G', a high viscous modulus G'', a Tan(δ) less than 1 (Tan(δ) = G'' / G'), and a high consistency G* (G* 2 =G' 2 + G'' 2 ).

[0127] In one embodiment, the aforementioned swellable material, preferably a swellable polymer, is neither water-soluble nor water-dispersible.

[0128] In another embodiment, the aforementioned swellable material, preferably a swellable polymer, may be a polymer that forms a hydrogel.

[0129] The aforementioned swellable polymers may be selected from high molecular weight hyaluronic acid, cross-linked hyaluronic acid, cross-linked polyethylene glycol, polyethylene glycol-crosslinked polylactic acid or polyglycolic acid or lactic acid-glycolic acid copolymer or polydioxanone, polystyrene-b-polyacrylic acid, polyethylene glycol-crosslinked PMVE / MA, cross-linked polyvinylpyrrolidone, sodium carboxymethyl starch; cellulose; natural and synthetic gums; alginate; sodium polyacrylate; PEG-crosslinked poly(methyl vinyl ether / maleic acid) (PMVE / MA) and its esters, PEG-crosslinked poly(methyl vinyl ether / maleic anhydride) (PMVE / MAH) and its esters, salts thereof, and mixtures thereof.

[0130] High molecular weight hyaluronic acid may have a molecular weight greater than 500 kDa, preferably greater than 1000 kDa, more preferably greater than 2100 kDa, and more preferably less than 10000 kDa.

[0131] Unless otherwise defined, molecular weight here refers to number-average molecular weight.

[0132] Poly(methyl vinyl ether / maleic acid) (PMVE / MA) and its esters and poly(methyl vinyl ether / maleic anhydride) (PMVE / MAH) are known to be Gantrez-type polymers.

[0133] The amount of swellable material (based on solids) in the microneedles of the microneedle sheet intended for use in the present invention, relative to the total weight of the microneedles, can be 1% by weight or more, preferably 5% by weight or more, and more preferably 10% by weight or more. The amount of swellable material (based on solids) in the microneedles of the microneedles of the microneedle sheet intended for use in the present invention, relative to the total weight of the microneedles, can be 30% by weight or less, preferably 25% by weight or less, and more preferably 20% by weight or less. Therefore, the amount of swellable material (based on solids) in the microneedles of the microneedles of the microneedle sheet intended for use in the present invention, relative to the total weight of the microneedles, can be from 1% by weight to 30% by weight, preferably 5% by weight to 25% by weight, and more preferably 10% by weight to 20% by weight.

[0134] If the microneedles intended for use in the microneedle sheet of the present invention comprise at least one swellable material, preferably at least one swellable polymer, then the microneedles may be swellable, thereby improving the aesthetic appearance of keratinous material (preferably skin, and more preferably facial skin) by reducing the appearance of wrinkles.

[0135] In other words, if microneedles are swellable, they can swell within the skin to further increase their volume, while simultaneously increasing their absorption of water, for example, from the skin. This volume expansion beneath the skin's surface at wrinkle sites effectively pushes wrinkles out of the skin, making them shallower and wider. Therefore, wrinkles can be reduced or made less noticeable.

[0136] The tip separation distance between each individual microneedle on the substrate can be modified to ensure that the microneedles penetrate the skin, lips, or scalp while having a sufficiently small separation distance to provide a high transdermal delivery rate.

[0137] In one embodiment, the tip separation distance between microneedles can range from 10 to 1000 µm, for example, from 30 to 800 µm or 50 to 600 µm. This allows for a trade-off between effective penetration of the stratum corneum by as many microneedles as possible and the necessary leeway for the microneedles to swell (if the microneedles are swellable).

[0138] In one implementation, the density of microneedles can be 100 to 2000 microneedles / cm². 2 Optimal density: 200 to 1000 microneedles / cm 2 And even more preferred is 200 to 500 microneedles / cm 2 .

[0139] (Polyols)

[0140] According to one embodiment, at least one microneedle of the microneedle sheet may contain at least one polyol. A single type of polyol may be used. Two or more polyols may be used in combination.

[0141] Preferred polyols are suitable for use at ambient temperature (e.g., 25°C) and atmospheric pressure (760 mmHg or 10). 5 It is in liquid form at Pa).

[0142] The term "polyol" here means an alcohol having two or more hydroxyl groups and does not include sugars or their derivatives. Sugar derivatives include sugar alcohols obtained by reducing one or more carbonyl groups of sugars, as well as sugars or sugar alcohols in which one or more hydrogen atoms of one or more hydroxyl groups are substituted with at least one substituent, such as an alkyl, hydroxyalkyl, alkoxy, acyl, or carbonyl group.

[0143] The polyols used in this invention are suitable for use at ambient temperature (e.g., 25°C) and atmospheric pressure (760 mmHg or 10). 5 The liquid is below (Pa).

[0144] Polyols can be C2-C containing at least two hydroxyl groups, and preferably two to five hydroxyl groups. 24 Polyols, preferably C2-C9 polyols.

[0145] Polyols can be natural or synthetic. Polyols can have straight-chain, branched-chain, or cyclic molecular structures.

[0146] The polyols can be selected from glycerol and its derivatives, as well as glycols and their derivatives. Specifically, the polyols can be selected from glycerol, diglycerol, polyglycerol, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, butanediol, pentanediol, hexanediol, and C6-C... 24 Polyethylene glycol, 1,3-propanediol, 1,4-butanediol and 1,5-pentanediol.

[0147] If the microneedles of the microneedle sheet contain polyols, the brittleness of the microneedles can be reduced or controlled.

[0148] (sugar)

[0149] According to one embodiment, at least one microneedle of the microneedle sheet may contain at least one sugar or a derivative thereof. A single type of sugar or a derivative thereof may be used. Two or more sugars, their derivatives, or a combination of sugars and their derivatives may be used.

[0150] The term "sugar" here refers to a polyol consisting of one or more glucose units and may have at least one carbonyl group. Derivatives of sugars include sugar alcohols obtained by reducing one or more carbonyl groups of sugars, as well as sugars or sugar alcohols in which one or more hydrogen atoms of one or more hydroxyl groups are substituted with at least one substituent, such as an alkyl, hydroxyalkyl, alkoxy, acyl, or carbonyl group.

[0151] Sugars can be selected from monosaccharides, oligosaccharides, polysaccharides, and mixtures thereof.

[0152] Monosaccharides may be selected from glucose, fructose, galactose, mannose, tarose, sorbose, xylose, lysolose, fucose, arabinose, rhamnose, ribose, ribulose, xylulose, sorbitol, triose, pentose, hexose, ketose, glucosamine, and mixtures thereof.

[0153] Oligosaccharides can be selected from maltose, lactose, saccharose, cellobiose, trehalose, sucrose, flucto-oligosaccharide, dextrin, and mixtures thereof. Preferred oligosaccharides may consist of 2 to 10 monosaccharides.

[0154] Polysaccharides can be selected from alginic acid, guar gum, xanthan gum, gum arabic, arabinogalactan, carrageenan, agar, ebony gum, tragacanth gum, tara gum, pectin, locust bean gum, cardolan, jelliangum, dextran, pullulan, hyaluronic acid, cellulose and its derivatives, and mixtures thereof.

[0155] The sugar derivative may be selected from erythritol, lactitol, maltitol, mannitol, sorbitol and xylitol, wherein at least one hydrogen atom in its hydroxyl group may be substituted by at least one substituent such as alkyl, hydroxyalkyl, alkoxy, acyl or carbonyl.

[0156] The sugars mentioned above can exist in the form of L or D isomers.

[0157] (Active ingredients in cosmetics)

[0158] According to one embodiment, at least one microneedle of the microneedle sheet used in the present invention may contain at least one cosmetic active ingredient. A single cosmetic active ingredient may be used. Two or more cosmetic active ingredients may be used in combination.

[0159] There are no restrictions on the types of active ingredients in cosmetics. Active ingredients in cosmetics can be selected from anti-aging agents, whitening agents, anti-wrinkle agents, antiperspirants, cooling agents, cleansing agents, skin texture agents, and combinations thereof.

[0160] For example, anti-aging agents can be used as active ingredients in cosmetics.

[0161] Examples of anti-aging agents include antioxidants, moisturizers, free radical scavengers, keratolytic agents (e.g., α or β-hydroxy acids), vitamins (e.g., vitamin C and its derivatives and vitamin E and its derivatives), anti-elastase and anti-collagenase agents, proteins, fatty acid derivatives, steroids, trace elements, bleaching agents, vegetable oils (e.g., almond oil), extracts of algae and plankton, hyaluronic acid or its salts (e.g., sodium hyaluronate), enzymes and coenzymes, flavonoids, ceramides, and mixtures thereof.

[0162] The amount of cosmetic active ingredients in the microneedles of the microneedle sheet used in the present invention is not limited, and may be 0.01% to 10% by weight, preferably 0.05% to 5% by weight, and more preferably 0.1% to 1% by weight relative to the total weight of the microneedles.

[0163] The amount of cosmetic active ingredients in the microneedles of the microneedles intended for use in the microneedle sheet of the present invention may be less than 0.01% by weight relative to the total weight of the microneedles. In one embodiment, the microneedles of the microneedle sheet according to the present invention may not contain cosmetic active ingredients.

[0164] (Substrate layer)

[0165] The microneedle sheet intended for use in this invention includes a substrate layer on which microneedles are present or located.

[0166] The substrate layer of the microneedle sheet intended for use in this invention may be soluble or insoluble.

[0167] Preferably, the substrate layer of the microneedle sheet intended for use in the present invention is soluble in water or can disintegrate in water.

[0168] The substrate layer of the microneedle sheet intended for use in this invention may contain at least one water-soluble or water-dispersible polymer as described above. In other words, the above explanation regarding water-soluble or water-dispersible polymers that may be contained in the microneedles of the microneedle sheet can be applied to water-soluble or water-dispersible polymers that may be contained in the substrate layer.

[0169] For example, relative to the total weight of the substrate layer, the amount (based on solids) of the water-soluble or water-dispersible polymer in the substrate layer of the microneedle sheet intended for use in the present invention may be 50% by weight or more, preferably 60% by weight or more, and more preferably 70% by weight or more. Relative to the total weight of the substrate layer, the amount (based on solids) of the water-soluble or water-dispersible polymer in the substrate layer of the microneedle sheet intended for use in the present invention may be 100% by weight or less, preferably 90% by weight or less, and more preferably 80% by weight or less. Therefore, relative to the total weight of the substrate layer, the amount (based on solids) of the water-soluble or water-dispersible polymer in the substrate layer of the microneedle sheet intended for use in the present invention may be from 50% by weight to 100% by weight, preferably 60% by weight to 90% by weight, and more preferably 70% by weight to 80% by weight.

[0170] The substrate and microneedles may or may not be integral.

[0171] If the substrate and microneedles are integral, the substrate and microneedles may contain at least one common water-soluble or water-dispersible polymer.

[0172] Therefore, in one embodiment, the substrate and microneedles can be a single element comprising at least one common water-soluble or water-dispersible polymer. Preferably, the single element can be prepared using the same water-soluble or water-dispersible polymer.

[0173] On the other hand, if the substrate and microneedles are not integral, that is, if the substrate and microneedles are different or dissimilar, then the substrate and microneedles can be made of different materials.

[0174] Therefore, in another embodiment, the substrate and the microneedles can be components of two different or dissimilar elements.

[0175] In a later embodiment, the substrate may be made of, for example, fibers or polymer films.

[0176] The fibers can be made from natural fibers such as cotton, semi-natural fibers such as viscose, synthetic fibers such as polyester and polypropylene fibers, and combinations thereof. The porous base layer can be made from woven or non-woven fabrics.

[0177] Polymer films can be made from synthetic resins such as polyurethane, polystyrene, polycarbonate, polyethylene terephthalate, ethylene-vinyl alcohol copolymer, polyethylene, polyester, polyamide, and combinations thereof.

[0178] The substrate can be cut to form patches, discs, masks, towels, gloves, precut rolls, or any other form suitable for cosmetic purposes.

[0179] (Additional layer)

[0180] The microneedle sheet intended for use in this invention may include at least one additional layer.

[0181] In one embodiment, the microneedle sheet includes at least one base layer as an additional layer, and the base layer is fixed to the substrate layer. For fixation, any means can be used to securely attach the base layer to the substrate layer. For example, any adhesive can be used to fix the base layer to the substrate layer.

[0182] The form and material of the substrate are unrestricted.

[0183] The substrate can be a porous or non-porous substrate.

[0184] The porous substrate can be composed of fibers. These fibers can be made from natural fibers such as cotton, semi-natural fibers such as viscose, synthetic fibers such as polyester and polypropylene fibers, and combinations thereof. The porous substrate can be made from woven or non-woven fabrics.

[0185] The non-porous substrate layer may be composed of a polymer membrane. The polymer membrane may be made of synthetic resins such as polyurethane, polystyrene, polycarbonate, polyethylene terephthalate, ethylene-vinyl alcohol copolymer, polyethylene, polyester, polyamide, and combinations thereof.

[0186] If the substrates of the microneedles and the microneedle sheets are different or dissimilar components, the substrate can act as a base layer. Therefore, in this case, a base layer may not be necessary.

[0187] In one embodiment, the microneedle sheet includes at least one adhesive layer as an additional layer, and the adhesive layer is fixed to a substrate layer or base layer (if present).

[0188] The material of the adhesive layer is not limited. It is preferable to use an adhesive layer that can be separated from the application surface of the applicator. For example, it is preferable to use an adhesive layer that can be peeled off or removed from the application surface of the applicator.

[0189] Pressure-sensitive adhesives are preferably used to form the adhesive layer. Any conventional pressure-sensitive adhesive can be used. The pressure-sensitive adhesive may contain at least one adhesive polymer. The adhesive polymer may be selected from (meth)acrylate polymers, vinyl acetate-acrylate copolymers, copolymers including polyisobutylene, polystyrene, or polybutadiene, rosin-based resins, polyterpene resins, petroleum-based resins, terpene phenolic resins, silicone resins, natural or synthetic rubbers, and mixtures thereof.

[0190] In one embodiment, the microneedle sheet includes at least one anti-adhesive layer as an additional layer, and the anti-adhesive layer is located on the adhesive layer.

[0191] The anti-stick layer protects the adhesive layer.

[0192] The material of the release layer is not limited. A film or sheet coated with at least one release agent, such as paper, is preferred. Any conventional release agent can be used. Preferably, the release layer can be easily peeled off from the adhesive layer.

[0193] It is preferable to form at least one tab for the release layer, because the user can grasp the tab to easily peel the release layer off the adhesive layer. The tab can be formed, for example, by slightly folding the tip or edge of the release layer.

[0194] Examples of microneedle sheets intended for use in this invention are shown in Figure 1 .

[0195] Figure 1 An example of a multilayer microneedle sheet 1 is shown. The multilayer microneedle sheet 1 includes microneedles 1-1, a substrate layer 1-2, a base layer 1-3, an adhesive layer 1-4, and an anti-adhesion layer 1-5. These layers are arranged in... Figure 1 The stacking order is shown.

[0196] In this example, substrate 1-2 is different from base layer 1-3. However, if the material of substrate 1-2 is the same as that of base layer 1-3, it is possible to omit base layer 1-3. In this case, adhesive layer 1-4 can be formed on substrate 1-3.

[0197] In this example, the release layer 1-5 has a tab 1-5-1. The user can grasp the tab 1-5-1 to peel the release layer 1-5 off from the adhesive layer 1-4. Therefore, when using the multilayer microneedle sheet 1, the user can easily peel the release layer 1-5 off from the adhesive layer 1-4.

[0198] (preparation)

[0199] There are no limitations on how the microneedles intended for use in this invention are prepared. It is possible to prepare the microneedles for use in this invention using conventional techniques such as molding, 3D printing, and droplet-born air blowing.

[0200] The microneedle sheet intended for use in this invention can be prepared, for example, by a method comprising the following steps: molding a composition containing at least one water-soluble or water-dispersible polymer as described above.

[0201] In one embodiment, the microneedle sheet intended for use in the present invention can be prepared by a method comprising the following steps:

[0202] (a) Provide a mold having a cavity corresponding to the negative image of the microneedle.

[0203] (b) Filling the cavity with a composition comprising at least one water-soluble or water-dispersible polymer as described above.

[0204] (c) For example, curing the composition by drying (and optionally heating) at room temperature for a period of time (e.g., several hours) to form microneedle sheets, and

[0205] (d) Remove the microneedles from the mold.

[0206] The mold can be made of organic materials such as polyamide and silicone and / or inorganic materials such as aluminum and iron.

[0207] If necessary, the above composition may contain at least one evaporable liquid component to enhance the flowability of the composition. Examples of evaporable liquid components are not limited, but water and alcohols (e.g., ethanol) are preferred.

[0208] The amount of evaporable liquid component relative to the total weight of the composition may be 10% by weight or more, preferably 20% by weight or more, and more preferably 30% by weight or more. The amount of evaporable liquid component relative to the total weight of the composition may be 98% by weight or less, preferably 95% by weight or less, and more preferably 90% by weight or less. Therefore, the amount of evaporable liquid component relative to the total weight of the composition may be from 10% by weight to 98% by weight, preferably from 20% by weight to 95% by weight, and more preferably from 30% by weight to 90% by weight.

[0209] The amount of the water-soluble or water-dispersible polymer in the composition, preferably flowable and more preferably in liquid form, may be from 2% to 90% by weight, preferably from 5% to 50% by weight, and more preferably from 5% to 30% by weight, relative to the total weight of the composition.

[0210] If necessary, the above composition may contain at least one additional polymer, such as the above-mentioned swellable polymer, and / or at least one polyol and / or at least one cosmetic active ingredient, as described above.

[0211] The microneedles and the substrate can be fabricated simultaneously using the molding process described above. In this case, the mold preferably also has a cavity for the substrate, and the cavity in the mold for the microneedles is connected to the cavity for the substrate. Therefore, the substrate and microneedles can be fabricated as a single element.

[0212] If the substrates of the microneedles and the microneedle sheets are different or dissimilar components, the microneedles can be fabricated using the molding process described above and fixed onto a separately provided substrate.

[0213] The shape of the microneedle sheet to be used in this invention is not limited, and it can be any shape, such as the shape of lips or a shape suitable for application to the face or head, depending on the application target of the microneedle sheet.

[0214] {device}

[0215] The kit according to the invention includes at least one device. This device is a cosmetic device, preferably a cosmetic device for keratin substances, and more preferably a cosmetic device for skin, particularly facial skin, and lips or scalp.

[0216] The device includes at least one applicator, at least one container, and at least one valve. The applicator includes at least one application surface, and the container contains at least one cosmetic composition.

[0217] An applicator, container, and valve are configured to supply a cosmetic composition to the application surface of the applicator via the valve. The microneedles can be connected to the applicator by attaching a substrate plate to the application surface of the applicator. Therefore, the applicator, container, and valve are configured to supply the cosmetic composition to the microneedles connected to the applicator.

[0218] This valve controls the supply of cosmetic composition to the microneedles attached to the applicator.

[0219] Therefore, the device can apply microneedles to keratin material, allowing the microneedles to contact the keratin material, and can also supply cosmetic compositions to the keratin material through the surface of the microneedles.

[0220] (Applicator)

[0221] The applicator in the kit according to the invention is used to apply microneedle sheets to keratinous materials such as skin, lips, and scalp.

[0222] The applicator includes at least one application surface. The application surface of the applicator can be applied to keratinous substances such as skin, especially facial skin, and lips or scalp. The application surface of the applicator can contact the keratinous substance.

[0223] The substrate layer of the microneedle sheet can be connected to the application surface of the applicator. Therefore, the microneedle sheet can be connected to the application surface.

[0224] Microneedles attached to the microneedle pads of the applicator can contact keratinous substances such as skin, lips, and scalp. Therefore, the microneedles can penetrate into the keratinous substance.

[0225] The means of attaching the substrate layer of the microneedle sheet to the application surface of the applicator are not limited. For example, the application surface of the applicator may have a convex surface, and the substrate layer of the microneedle may be inserted into the convex surface.

[0226] The substrate layer of the preferred microneedle sheet may be an adhesive, more preferably an adhesive that can be peeled off or removed from the application surface, and even more preferably a pressure-sensitive adhesive attached to the application surface of the applicator.

[0227] If the microneedle sheet includes at least one base layer on the substrate layer, as described above, then the base layer can be connected to the application surface of the applicator.

[0228] Preferably, the microneedle sheet includes at least one adhesive layer on a substrate or base layer, as described above, and the adhesive layer of the microneedle sheet is connected to the application surface of the applicator.

[0229] For example, for Figure 1 In the example of the microneedle sheet shown, when using the microneedle sheet 1, the anti-adhesive layer 1-5 is peeled off from the surface of the adhesive layer 1-4, and the adhesive layer 1-4 is attached to the application surface of the applicator.

[0230] The surface to be applied can be planar or curved (non-planar).

[0231] The type of applicator is not limited, as long as the applicator includes at least one application surface.

[0232] If the application surface is curved, for example, an applicator comprising at least one cylindrical roller with a curved end face (where the curved end face of the cylindrical roller constitutes the application surface) can be used as an applicator.

[0233] (container)

[0234] The container in the kit according to the invention is used to store cosmetic compositions.

[0235] The shape of the container is not limited and can be any form, as long as it can hold the cosmetic composition. For example, the container can be cylindrical or tubular. Preferably, the container is in a form that is easy to operate with one hand, such as a cylinder.

[0236] The material of the container is not limited and can be either soft or rigid. Non-limiting examples of container materials include plastics, metals, and composite materials of different materials.

[0237] The volume of the container is not limited and can depend on the intended use of the kit according to the invention. For example, for single use (the cosmetic composition in the container should be used only once), the volume of the container can be up to 10 ml. On the other hand, for multiple use (the cosmetic composition in the container can be used multiple times), the volume of the container can be 50 ml or more.

[0238] The container may have at least one opening through which the cosmetic composition in the container can be discharged.

[0239] The container may have a pumping system that facilitates the expulsion of the cosmetic composition from the opening. The pumping system could be, for example, a plunger within the container that is manually operable and pushes the cosmetic composition towards the opening. Alternatively, if the body of the container is made of a soft material, a pumping system may not be necessary, as the user can squeeze the container to expel the cosmetic composition from the opening.

[0240] (valve)

[0241] The valve in the device of the kit according to the invention is used to control the supply of cosmetic composition from the container to the microneedles connected to the application surface of the applicator.

[0242] A valve here refers to an element that can regulate or control the flow of fluid (e.g., a cosmetic composition) in a container by opening, closing, or partially blocking a flow passage.

[0243] The type of valve is not limited, as long as it can control the supply of the cosmetic composition from the container to the application surface of the applicator or to the microneedles attached to the application surface of the applicator.

[0244] "Control" includes stopping or starting the supply of a cosmetic composition, and may also include adjusting the amount of cosmetic composition to be supplied.

[0245] Any valve can be used in the device according to the kit of the invention. The valve can be selected from conventional valves, such as gate valves, ball valves, butterfly valves, and diaphragm valves. Preferably, the valve is a gate valve. A gate valve prevents the flow of fluid. Therefore, a gate valve can cut off the flow of the cosmetic composition from the container to the applicator. More preferably, the valve includes a rotating disc having at least one eccentric through-hole that connects to the opening of the container.

[0246] After the microneedle sheet is attached to the application surface of the applicator, the valve can supply the cosmetic composition onto the microneedle sheet.

[0247] (Implementation Plan)

[0248] Figure 2An embodiment of the device according to the kit is shown. The device can supply the cosmetic composition in its "on" position, but it cannot supply the cosmetic composition in its "off" position. Figures 3A and 3B show schematic diagrams of the device in its "on" and "off" positions.

[0249] Figure 2 The device 2 shown includes a container 2-1, a valve 2-2, and an applicator 2-3 in the form of a cylindrical roller.

[0250] Figure 2 The container 2-1 shown is in the form of a hollow cylinder and contains a cosmetic composition. The container 2-1 has an opening 2-1-1, as shown in Figures 3A and 3B. The cosmetic composition in the container 2-1 can be discharged from the container 2-1 through the opening 2-1-1. The opening 2-1-1 is formed at an off-center position on the top surface of the container 2-1.

[0251] Figure 2 The valve 2-2 shown includes a rotating disk 2-2-2 with an eccentric through-hole 2-2-1, as shown in Figures 3A and 3B. The eccentric through-hole 2-2-1 can face the applicator 2-3. The valve 2-2 can form an on / off mechanism with the container 2-1.

[0252] As shown in Figure 3A, in the "closed" position, the eccentric through-hole 2-2-1 of valve 2-2 is not connected to the opening 2-1-1 of container 2-1, and the opening 2-1-1 is closed by the rotating disk 2-2-2. Therefore, the cosmetic composition in container 2-1 cannot be discharged from the opening 2-1-1 and the eccentric through-hole 2-1-1.

[0253] On the other hand, if the user rotates the rotating disk 2-2-2 to the "open" position, as shown in Figure 3B, the eccentric through hole 2-2-1 can connect to the opening 2-1-1, so that the cosmetic composition in the container 2-1 can be discharged from the opening 2-1-1 and the eccentric through hole 2-1-1.

[0254] Figure 2 The applicator 2-3 shown has a curved end face 2-3-1, and the curved end face 2-3-1 of the applicator 2-3 constitutes an application surface, to which the substrate layer of the microneedle sheet can be connected. The application surface can face the eccentric through-hole 2-2-1 of the valve 2-2.

[0255] In the "closed" position shown in Figure 3A, the cosmetic composition in container 2-1 cannot be supplied to the curved end face 2-3-1 of applicator 2-3, i.e., the application surface of applicator 2-3. Therefore, if the microneedle sheet is connected to applicator 2-3, the cosmetic composition cannot be supplied to the microneedle sheet.

[0256] On the other hand, in the "open" position shown in Figure 3B, the cosmetic composition in container 2-1 can be supplied to the application surface of the curved end face 2-3-1 of applicator 2-3, i.e., the application surface of applicator 2-3. Therefore, if the microneedle sheet is connected to applicator 2-3, the cosmetic composition can be supplied to the microneedle sheet.

[0257] exist Figure 2 In the embodiments shown in Figures 3A and 3B, the container 2-1 is cylindrical and can be used as a handle for the device 2 by the user. Therefore, the user of the device 2 can hold the container 2-1 to use the device 2.

[0258] When using microneedles, the microneedles are connected to the applicator 2-3 by attaching the substrate layer of the microneedles to the application surface on the curved end face 2-3-1 of the applicator 2-3, which is in the form of a cylindrical roller.

[0259] Figure 4 Device 2 is shown, in which microneedle sheet 1 is connected to applicator 2-3. Microneedle sheet 1 is connected to an application surface on the curved end face of applicator 2-3 such that the substrate layer of microneedle sheet 1 is in contact with the application surface. Therefore, the microneedles of microneedle sheet 1 can stand upright on the curved end face of applicator 2-3.

[0260] At least a portion of the curved end face of the applicator 2-3 may be covered by the microneedle sheet 1. Preferably, the entire curved end face of the applicator 2-3 is covered by the microneedle sheet 1.

[0261] Figure 5 The device 2 with microneedle 1 is shown.

[0262] When using microneedle sheet 1, such as Figure 4 As shown, the microneedle sheet 1 is connected to the applicator 2-3 by connecting the substrate layer of the microneedle sheet 1 to the application surface of the curved end face of the applicator 2-3, and as... Figure 5 As shown, a device 2 with microneedles 1 is applied to keratinous material 3 (e.g., skin, lips, and scalp), allowing the applicator 2-3 to rotate over the keratinous material 3. The microneedles of the microneedles 1 on the device 2 can contact and penetrate the keratinous material 3, thereby providing the keratinous material with cosmetic effects derived from microneedles.

[0263] Furthermore, when valve 2-2 is turned to its "open" position, the cosmetic composition in container 2-1 is supplied to the microneedle sheet 1 on the application surface of applicator 2-3. Therefore, the microneedle sheet 1 also provides the keratin substance 3 with cosmetic effects derived not only from the microneedles but also from the cosmetic composition. Due to the action of the microneedles, the cosmetic composition can penetrate deeply into the keratin substance 3.

[0264] Turning valve 2-2 to its "closed" position will stop the supply of cosmetic composition to the microneedle pads.

[0265] {case}

[0266] The kit according to the invention may include at least one housing.

[0267] The housing may include microneedle sheets to protect the microneedle sheets, and in particular the microneedles within them. Therefore, it is possible to safely store the microneedle sheets without damaging the microneedles.

[0268] The preferred housing comprises at least one soft and / or porous material. When not in use, the microneedles of the microneedle sheet can safely penetrate into the soft material or may be located in the pores of the porous material.

[0269] Soft and / or porous materials can reduce or eliminate damage to microneedles. Therefore, the use of soft and / or porous materials can protect microneedles in a safer manner.

[0270] Flexible articles may consist of at least one flexible synthetic resin. Flexible synthetic resins may be selected from polyurethane, polystyrene, polycarbonate, polyethylene terephthalate, ethylene-vinyl alcohol copolymer, polyethylene, polyester, polyamide, and combinations thereof, and may include at least one softening agent.

[0271] Porous products can be made of fibers. These fibers can be natural fibers such as cotton, semi-natural fibers such as viscose, synthetic fibers such as polyester and polypropylene fibers, and combinations thereof. Porous products can be made from woven or non-woven fabrics.

[0272] Soft and porous products can be made of sponges. Sponges can be made from foamed synthetic resins such as flexible polyurethane foam.

[0273] The soft and / or porous articles are preferably in sheet form. The soft and / or porous sheets should have a thickness greater than the height of the microneedles. For example, if the microneedles have a height of 100 to 400 micrometers, the thickness of the soft or porous sheet should be 200 to 500 micrometers.

[0274] Figure 6 An example of a housing is shown. In Figure 6 In this design, the housing 4 is in the shape of a tray with an opening. The material of the housing 4 is not limited. For example, at least one material selected from metals and synthetic resins can be used as the material of the housing 4.

[0275] exist Figure 6 In the example shown, the housing 4 includes a porous sheet 5. The porous sheet 5 is made of sponge or woven or nonwoven fabric.

[0276] like Figure 6As shown, when the microneedle sheet 1 is not in use, it is stored in the housing 4, and the microneedles of the microneedle sheet 1 can penetrate into the porous sheet 5 for protection. Therefore, the microneedle sheet 1 can be stored under the protection of the microneedles.

[0277] The microneedles in the housing can preferably be packaged by covering the opening of the housing 4 or both the opening of the housing 4 and the housing 4 itself with a film, for example, a thin film (e.g., a transparent resin film).

[0278] {Cosmetic Composition}

[0279] The container in the kit according to the invention contains at least one cosmetic composition.

[0280] Cosmetic compositions can be used as pretreatment or posttreatment compositions for keratin substances.

[0281] The cosmetic composition preferably contains water. Therefore, the cosmetic composition may be in the form of, for example, an aqueous solution.

[0282] On the other hand, the cosmetic composition may contain at least one oil and water, preferably in the form of an O / W emulsion.

[0283] (Oil)

[0284] The cosmetic composition may contain at least one oil. If two or more oils are used, they may be the same or different.

[0285] "Oil" here refers to a fatty compound or substance that is in liquid or paste (non-solid) form at room temperature (25°C) under atmospheric pressure (760 mmHg). Oils are those commonly used in cosmetics, either alone or in combination. These oils can be volatile or non-volatile.

[0286] Oils can be non-polar oils, such as hydrocarbon oils, silicone oils, etc.; polar oils, such as vegetable or animal oils, as well as ester or ether oils; or mixtures thereof.

[0287] Oils can be selected from plant or animal sources, synthetic oils, silicone oils, hydrocarbon oils, and fatty alcohols.

[0288] Examples of vegetable oils include, for example, flaxseed oil, camellia oil, macadamia oil, corn oil, mink oil, olive oil, avocado oil, tea oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil, rapeseed oil, sesame oil, soybean oil, peanut oil, and mixtures thereof.

[0289] Examples of animal oils include squalene and squalane.

[0290] Examples of synthetic oils include alkane oils such as isododecane and isohexadecane; ester oils; ether oils; and synthetic triglycerides.

[0291] Ester oils are preferably saturated or unsaturated, straight-chain or branched C1-C. 26 Aliphatic monocarboxylic acids or polycarboxylic acids with saturated or unsaturated, straight-chain or branched C1-C bonds. 26 A liquid ester of an aliphatic monohydric alcohol or polyhydric alcohol, wherein the total number of carbon atoms in the ester is greater than or equal to 10.

[0292] Preferably, for the ester of a monohydric alcohol, at least one of the alcohol and acid from which the ester of the present invention is derived is branched.

[0293] Among the monoesters of monobasic acids and monohydric alcohols, ethyl palmitate, ethylhexyl palmitate, isopropyl palmitate, dioctyl carbonate, and alkyl myristate esters, such as isopropyl myristate or ethyl myristate, isocetyl stearate, 2-ethylhexyl isononanoate, isonononanoate, isodecanyl neopentanoate, and isostearyl neopentanoate may be mentioned.

[0294] C4-C can also be used 22 Dicarboxylic or tricarboxylic acids and C1-C 22 Esters of alcohols, as well as monocarboxylic acids, dicarboxylic acids, or tricarboxylic acids with non-sugar C4-C 26 Esters of dihydroxyols, trihydroxyols, tetrahydroxyols or pentahydroxyols.

[0295] Specifically mentioned are: diethyl sebacate; isopropyl lauroyl sarcosinate; diisopropyl sebacate; bis(2-ethylhexyl) sebacate; diisopropyl adipicate; di-n-propyl adipicate; dioctyl adipicate; bis(2-ethylhexyl) adipicate; diisostearate; bis(2-ethylhexyl) maleate; triisopropyl citrate; triisoceryl citrate; triisostearate; trilactyl glycerol; trioctyl glycerol; tri(octyldodecyl) citrate; trioleyl citrate; neopentyl glycol diheptanoate; diethylene glycol diisononanoate.

[0296] As an ester oil, C6-C can be used. 30 And C is preferred 12 -C 22 Glycoesters and diesters of fatty acids. Recall that the term "sugar" refers to an oxygen-carrying hydrocarbon-based compound containing several alcohol functions, with or without aldehyde or ketone functions, and containing at least four carbon atoms. These sugars can be monosaccharides, oligosaccharides, or polysaccharides.

[0297] Suitable examples of sugars that may be mentioned include sucrose (or saccharose), glucose, galactose, ribose, fucose, maltose, fructose, mannose, arabinose, xylose, and lactose, and their derivatives, especially alkyl derivatives, such as methyl derivatives, such as methyl glucose.

[0298] The glycoesters of fatty acids may be selected, in particular, from the sugars described above and from straight-chain or branched, saturated or unsaturated C6-C groups. 30 And C is preferred 12 -C 22 Esters or mixtures of fatty acids. If these compounds are unsaturated, they may have one to three conjugated or non-conjugated carbon-carbon double bonds.

[0299] The esters according to this variant can also be selected from monoesters, diesters, triesters, tetraesters and polyesters, and mixtures thereof.

[0300] These esters can be, for example, oleate, laurate, palmitate, myristate, benzyl ester, cocoate, stearate, linoleate, linolenic acid ester, decanoate and arachidonic acid ester, or mixtures thereof, such as, in particular, mixed esters of oleopalmitate, oleostearate and palmostearate, and pentaerythritol tetra(ethylhexanoate).

[0301] More specifically, monoesters and diesters are used, and in particular sucrose, glucose or methyl glucose monooleate or dioleate, stearate, benzyl ester, oleopalatate, linoleate, linolenic acid ester and oleostearate.

[0302] An example that can be mentioned is a product sold by Amerchol under the name Glucate® DO, which is methyl glucosyl dioleate.

[0303] Examples of preferred ester oils include, for example, diisopropyl adipate, dioctyl adipate, 2-ethylhexyl hexanoate, ethyl laurate, cetyl octanoate, octyl dodecyl octanoate, isodecanyl neopentanoate, myristyl propionate, 2-ethylhexyl 2-ethylhexanoate, 2-ethylhexyl octanoate, 2-ethylhexyl octanoate / decanoate, methyl palmitate, ethyl palmitate, isopropyl palmitate, dioctyl carbonate, isopropyl lauroyl sarcosinate, isononyl isononanoate, ethylhexyl palmitate, isohexyl laurate, isocetyl stearate, isopropyl isostearate, isopropyl myristate, isodecanyl oleate, tri(2-ethylhexanoate)glyceryl ester, pentaerythritol tetra(2-ethylhexanoate)ester, 2-ethylhexyl succinate, diethyl sebacate, and mixtures thereof.

[0304] Examples of synthetic triglycerides include, for example, capryl caprylyl glyceride, trimyristic glyceride, tripalmitic glyceride, trilinolenic glyceride, trilauric glyceride, tridecanoic glyceride, tricaprylic glyceride, tricaprylic glyceride, tri(decanoic acid / caprylic acid) glyceride, and tri(decanoic acid / caprylic acid / linolenic acid) glyceride.

[0305] Examples of silicone oils include linear organopolysiloxanes, such as dimethyl polysiloxane, methylphenyl polysiloxane, methylhydropolysiloxane, etc.; cyclic organopolysiloxanes, such as cyclohexylsiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecylcyclohexasiloxane, etc.; and mixtures thereof.

[0306] Preferably, the silicone oil is selected from liquid polydialkylsiloxanes, especially liquid polydimethylsiloxane (PDMS), and liquid polyorganosiloxanes containing at least one aryl group.

[0307] These silicone oils can also be organically modified. Organically modified silicones usable according to the present invention are silicone oils as defined above and whose structure contains one or more organic functional groups linked via hydrocarbon-based groups.

[0308] Organopolysiloxanes are defined in more detail in Walter Noll's... Chemistry and Technology of Silicones (1968), Academic Press. They can be volatile or non-volatile.

[0309] When silicones are volatile, they are more specifically selected from those with boiling points between 60°C and 260°C, and even more specifically selected from:

[0310] (i) Cyclic polydialkylsiloxanes comprising 3 to 7, preferably 4 to 5, silicon atoms. These are, for example, octamethylcyclotetrasiloxanes sold by Union Carbide under the name Volatile Silicone® 7207 or by Rhodia under the name Silbione® 70045V2; decamethylcyclopentasiloxanes sold by Union Carbide under the name Volatile Silicone® 7158 and by Rhodia under the name Silbione® 70045 V5; and dodecylmethylcyclopentasiloxanes sold by MomentivePerformance Materials under the name Silsoft 1217; and mixtures thereof. Also mentioned are cyclic copolymers of the type of dimethylsiloxane / methylalkylsiloxane, such as Silicon Volatile® FZ 3109 sold by Union Carbide, which has the following formula:

[0311]

[0312] May also be mentioned mixtures of cyclic polydialkylsiloxanes with organosilicon compounds, such as mixtures of octamethylcyclotetrasiloxane and tetra(trimethylsilyl)pentaerythritol (50 / 50) and mixtures of octamethylcyclotetrasiloxane and oxy-1,1'-bis(2,2,2',2',3,3-hexa(trimethylsiloxy))neopentane; and

[0313] (ii) Contains 2 to 9 silicon atoms and has a silicon content of less than or equal to 5 × 10⁻⁶ at 25 °C. -6 m 2 Linearly volatile polydialkylsiloxanes with a viscosity of / s. An example is decamethyltetrasiloxane, specifically marketed by Toray Silicone under the name SH 200. Silicones belonging to this category are also described in an article by Todd & Byers in Cosmetics and Toiletries, Vol. 91, January 1976, pp. 27-32. Volatile Silicone Fluids for Cosmetics The viscosity of silicone was measured at 25°C according to Appendix C of ASTM Standard 445.

[0314] Non-volatile polydialkylsiloxanes may also be used. These non-volatile silicones are particularly selected from polydialkylsiloxanes, with polydimethylsiloxanes containing trimethylsilyl end groups being the most prominent example.

[0315] Among these polydialkylsiloxanes, the following products may be mentioned in a non-limiting manner:

[0316] -Silbione series 47 and 70 sold by Rhodia ® Oil or Mirasil ® Oil, for example, oil 70 047 V500 000;

[0317] Mirasil sold by Rhodia ® Series of oils;

[0318] - Oils from Dow Corning's 200 series, for example, with a viscosity of 60,000 mm. 2 DC200 / s; and

[0319] -Viscasil from General Electric ® Oils and certain oils from the SF series (SF 96, SF 18) from General Electric.

[0320] Also mentioned are polydimethylsiloxanes containing dimethylsilanol end groups, known by the name polydimethylsiloxane alcohol (CTFA), such as oils from Rhodia's 48 series.

[0321] Among silicones containing aryl groups, polydiarylsiloxanes, especially polydiphenylsiloxanes, and polyalkylarylsiloxanes, such as phenyl silicone oils, can be mentioned.

[0322] Phenyl silicone oil can be selected from phenyl silicones of the following formula:

[0323]

[0324] in:

[0325] R1 to R 10 Independently saturated or unsaturated, linear, cyclic or branched, C1-C based 30 Hydrocarbon groups, preferably based on C1-C 12 Hydrocarbon groups, and more preferably groups based on C1-C6 hydrocarbons, particularly methyl, ethyl, propyl, or butyl groups, and

[0326] m, n, p, and q are independent integers from 0 to 900 (inclusive), preferably from 0 to 500 (inclusive), and more preferably from 0 to 100 (inclusive).

[0327] The condition is that the sum of n+m+q is not 0.

[0328] Examples that may be mentioned include products sold under the following names:

[0329] - Silbione® oil from Rhodia's 70 641 series;

[0330] - Oils from Rhodorsil® 70 633 and 763 series from Rhodia;

[0331] -Oil from Dow Corning 556 cosmetic grade fluid;

[0332] - Silicones from Bayer's PK series, such as product PK20;

[0333] - Certain oils from General Electric's SF series, such as SF 1023, SF 1154, SF 1250 and SF1265.

[0334] As a phenyl silicone oil, phenyl polytrimethylsiloxane (in the above formula, R1 to R...) 10 Methyl groups are preferred; p, q, and n = 0; m = 1.

[0335] Organically modified liquid silicones may contain polyvinyloxy and / or polypropyleneoxy groups, in particular. Therefore, silicone KF-6017 from Shin-Etsu and oils Silwet® L722 and L77 from Union Carbide are mentioned.

[0336] Hydrocarbon oils can be selected from:

[0337] - Straight-chain or branched, optionally cyclic C6-C 16 Lower alkanes. Examples that may be mentioned include hexane, undecane, dodecane, tridecane, and isoparaffins such as isohexadecane, isodecane, and isodecane; and

[0338] - Straight-chain or branched hydrocarbons containing more than 16 carbon atoms, such as liquid paraffin, liquid petroleum jelly, polydecene and hydrogenated polyisobutylene (e.g., Parleam®), and squalane.

[0339] Preferred examples of hydrocarbon oils may include, for example, straight-chain or branched hydrocarbons such as isohexadecane, isodecane, squalane, mineral oils (e.g., liquid paraffin), paraffin, petrolatum or petrolatum, naphthalene, etc.; hydrogenated polyisobutylene, isoeicosan, and decene / butene copolymers; and mixtures thereof.

[0340] The term "fatty" in fatty alcohols indicates the presence of a relatively large number of carbon atoms. Therefore, alcohols having four or more, preferably six or more, and more preferably twelve or more carbon atoms are included in the scope of fatty alcohols. Fatty alcohols can be saturated or unsaturated. Fatty alcohols can be straight-chain or branched.

[0341] Fatty alcohols may have the structure R-OH, wherein R is selected from saturated and unsaturated, straight-chain and branched groups containing 4 to 40 carbon atoms, preferably 6 to 30 carbon atoms, and more preferably 12 to 20 carbon atoms. In at least one embodiment, R may be selected from C 12 -C 20 Alkyl and C 12 -C 20 Alkenyl group. R may or may not be substituted with at least one hydroxyl group.

[0342] Examples of fatty alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, betaine alcohol, undecenol, myristyl alcohol, octyldodecyl alcohol, hexyldecyl alcohol, oleyl alcohol, linoleyl alcohol, palm oil alcohol, arachidonic alcohol, guarana alcohol, and mixtures thereof.

[0343] Preferably, the fatty alcohol is a saturated fatty alcohol.

[0344] Therefore, fatty alcohols can be selected from straight-chain or branched, saturated or unsaturated C6-C chains. 30Alcohols, preferably straight-chain or branched saturated C6-C alcohols. 30 Alcohols, and more preferably straight-chain or branched saturated C40 ... 12 -C 20 alcohol.

[0345] The term "saturated fatty alcohol" here refers to an alcohol having a long aliphatic saturated carbon chain. Preferably, saturated fatty alcohols are selected from any straight-chain or branched saturated C6-C... 30 Fatty alcohols. In straight-chain or branched saturated C6-C... 30 Among fatty alcohols, straight-chain or branched saturated C-chains are preferred. 12 -C 20 Fatty alcohols. More preferably, any straight-chain or branched saturated C2O3 can be used. 16 -C 20 Fatty alcohols. Branched C-chain fatty acids may be used, or even more preferably. 16 -C 20 Fatty alcohols.

[0346] Examples of saturated fatty alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, betaine alcohol, undecenyl alcohol, myristyl alcohol, octyldodecyl alcohol, hexyldecyl alcohol, and mixtures thereof. In one embodiment, cetyl alcohol, stearyl alcohol, octyldodecyl alcohol, hexyldecyl alcohol, or mixtures thereof (e.g., cetearyl alcohol) and betaine alcohol may be used as saturated fatty alcohols.

[0347] According to at least one embodiment, the fatty alcohol used in the cosmetic composition is preferably selected from cetyl alcohol, octyldodecyl alcohol, hexyldecyl alcohol, and mixtures thereof.

[0348] Preferably, the oil is selected from ester oils, hydrocarbon oils, silicone oils, fatty alcohols, and mixtures thereof.

[0349] The amount of oil in the cosmetic composition, relative to the total weight of the cosmetic composition, may be 1% by weight or more, preferably 5% by weight or more, and more preferably 10% by weight or more. The amount of oil in the cosmetic composition, relative to the total weight of the cosmetic composition, may be 30% by weight or less, preferably 25% by weight or less, and more preferably 20% by weight or less. The amount of oil in the cosmetic composition, relative to the total weight of the cosmetic composition, may be from 1% by weight to 30% by weight, preferably 5% by weight to 25% by weight, and more preferably 10% by weight to 20% by weight.

[0350] Oils can form the fatty phase of cosmetic compositions.

[0351] If the cosmetic composition is in the form of an O / W emulsion, the oil can form a dispersed fatty phase in the O / W emulsion.

[0352] (water)

[0353] This cosmetic composition may contain water.

[0354] The amount of water relative to the total weight of the cosmetic composition may be 50% by weight or more, preferably 55% by weight or more, and more preferably 60% by weight or more. The amount of water relative to the total weight of the cosmetic composition may be 95% by weight or less, preferably 90% by weight or less, and more preferably 85% by weight or less. The amount of water in the cosmetic composition relative to the total weight of the cosmetic composition may range from 50% by weight to 95% by weight, preferably 55% by weight to 90% by weight, and more preferably 60% by weight to 85% by weight.

[0355] Water can form the aqueous phase of cosmetic compositions.

[0356] If the cosmetic composition is in the form of an O / W emulsion, water can form a continuous aqueous phase in the O / W emulsion.

[0357] (Other ingredients)

[0358] Cosmetic compositions may contain at least one structuring agent or gelling agent. Examples of structuring agents or gelling agents include, but are not limited to, cellulose derivatives (methylcellulose, methylethylcellulose), plant-derived hydrocolloids (alginate, carrageenan, pectin, etc.), starch derivatives, and gums such as xanthan gum.

[0359] Cosmetic compositions may contain wetting agents, such as polyols as described above.

[0360] A cosmetic composition may contain at least one cosmetic active ingredient as described above.

[0361] Cosmetic compositions may also include various excipients commonly used in cosmetic compositions, such as anionic, nonionic, cationic, and amphoteric or zwitterionic surfactants; anionic, nonionic, cationic, and amphoteric or zwitterionic polymers; pH adjusters; skin tone alterers; anti-acne agents; and combinations thereof.

[0362] (form)

[0363] The preferred cosmetic composition includes a large amount of water because the dissolution of microneedles becomes easier. Therefore, the cosmetic composition is preferably in the form of an aqueous solution or an O / W emulsion.

[0364] In one embodiment, the cosmetic composition may be in the form of a hydrogel (or hydrogel) and may include about 50% to about 99.9% by weight (preferably about 60% to about 95% by weight, and more preferably about 70% to about 90% by weight) of water and about 50% to about 99.9% by weight (preferably about 5% to about 40% by weight, and more preferably about 10% to about 30% by weight) of other cosmetic ingredients.

[0365] (preparation)

[0366] Cosmetic compositions that can be used in this invention can be prepared by mixing, for example, oils, water and other ingredients (if necessary) as described above.

[0367] The methods and means of mixing the above-mentioned ingredients are not limited. Any conventional methods and means can be used to mix the above-mentioned ingredients to prepare cosmetic compositions that can be used in this invention.

[0368] [Beauty Methods]

[0369] The cosmetic method according to the present invention for use with keratinous materials such as skin, lips, and scalp includes the following steps:

[0370] At least one microneedle sheet is attached to at least one applicator having at least one application surface.

[0371] in

[0372] The microneedle sheet comprises a substrate layer and a plurality of microneedles on the substrate layer, the microneedles comprising at least one water-soluble or water-dispersible polymer.

[0373] The applicator is included in at least one device comprising at least one container and at least one valve, the container containing at least one cosmetic composition.

[0374] It is achieved by attaching the substrate layer of the microneedle sheet to the application surface of the applicator;

[0375] as well as

[0376] Apply the applicator to the keratin material so that the microneedles come into contact with the keratin material.

[0377] in

[0378] Configure an applicator, container, and valve to supply the cosmetic composition via the valve to microneedles connected to the applicator.

[0379] The valve controls the supply of the cosmetic composition to the microneedles connected to the applicator, and

[0380] During the step of applying an applicator to keratinous material, a cosmetic composition is supplied onto microneedle sheets.

[0381] The cosmetic method according to the invention can be implemented using the kit according to the invention.

[0382] The cosmetic method according to the invention is intended for use on keratinous substances such as skin, lips and scalp, preferably skin, and more preferably facial skin.

[0383] Before attaching the microneedles to the applicator, configure the applicator, container, and valve to supply the cosmetic composition to the application surface of the applicator via the valve.

[0384] When performing the cosmetic method according to the invention, the microneedle sheet is connected to the applicator by connecting the substrate layer of the microneedle to the application surface of the applicator, so as to fix the microneedle sheet to the applicator.

[0385] Preferably, the microneedle sheet is stored in the housing as described above and removed from the housing when the microneedle sheet is used.

[0386] Preferably, the microneedle sheet is contained in at least one base layer on the substrate layer, and the base layer is connected to the application surface of the applicator.

[0387] Preferably, the microneedle sheet is contained in at least one adhesive layer on the substrate layer and the base layer, and the adhesive layer is connected to the application surface of the applicator.

[0388] More preferably, the microneedle sheet includes at least one anti-adhesive layer on the adhesive layer, and the anti-adhesive layer is removed from the surface of the adhesive layer when the microneedle sheet is used.

[0389] After the microneedle pads are connected to the applicator, a container and valve are configured to supply the cosmetic composition to the microneedle pads connected to the applicator via the valve. The valve controls the supply of the cosmetic composition to the microneedle pads connected to the applicator.

[0390] Next, an applicator is applied to the keratin material so that the microneedles come into contact with it. In other words, microneedle sheets are applied to the keratin material.

[0391] The above application can be performed by the user using a device equipped with an applicator.

[0392] If the applicator is in roller form, the applicator with microneedles can be applied to the keratin material by rolling it over it. For example, the applicator can be rolled back and forth over the keratin material. The number of cycles will depend on various factors, such as the sensitivity of the keratin material and the cosmetic composition to be used in conjunction with the microneedles. In an embodiment, the back-and-forth motion can be repeated 4 or 5 times, which may take about 1 minute if the keratin material is facial skin.

[0393] Therefore, the microneedles in microneedles can penetrate into keratinous material to provide cosmetic effects.

[0394] The cosmetic method according to the invention can, for example, improve the aesthetic appearance of keratin substances by reducing the appearance of wrinkles or by providing cosmetic active ingredients (if present) to keratin substances in microneedles.

[0395] A decrease in the amount of matrix (such as the epidermis) in the skin tends to lead to reduced skin thickness and decreased skin elasticity, resulting in wrinkle formation. Microneedling can increase the amount of matrix in the skin, thereby increasing skin elasticity and reducing wrinkles.

[0396] If the microneedles (especially the distal portion) are swellable, they can swell within the skin to further increase their volume, while simultaneously increasing their absorption of water, for example, from the skin. This volume expansion beneath the skin's surface in areas of wrinkles effectively pushes the wrinkles out of the skin, making them shallower and wider. Therefore, wrinkles can be reduced or made less noticeable.

[0397] Therefore, the preferred cosmetic method according to the present invention includes the following steps: pressing a microneedle sheet onto a keratin material to firmly insert the microneedles of the microneedle sheet into the keratin material, such as skin, lips, and scalp.

[0398] In a particular embodiment, the cosmetic method according to the invention can be used to apply semi-permanent or permanent cosmetic treatments to keratinous substances such as skin.

[0399] According to the cosmetic method of the present invention, the cosmetic composition can be used in combination with microneedle sheets.

[0400] Therefore, during the step of applying the applicator to a keratinous substance, a cosmetic composition can be supplied to a microneedle sheet. The cosmetic composition can be present on the microneedle sheet, particularly within the microneedles of the microneedle sheet. The cosmetic composition can be transferred from the microneedle sheet to the surface of the keratinous substance, such as the skin, lips, and scalp. Thus, the cosmetic composition can be applied to the keratinous substance from the microneedle sheet.

[0401] Because cosmetic compositions can be applied to keratinous substances in combination with microneedles, they can penetrate the keratinous substance relatively easily through the pores / cavities formed thereon by the microneedles, compared to not using microneedles. Therefore, cosmetic compositions can penetrate much deeper into the keratinous substance compared to not using microneedles, and a relatively large amount of cosmetic composition can be delivered to the keratinous substance.

[0402] Furthermore, microneedles can dissolve or disperse in keratin substances and / or cosmetic compositions (which may preferably contain water), thus making it impossible to reuse microneedles.

[0403] Furthermore, the cosmetic method according to the present invention allows cosmetic compositions to be applied to keratin substances in an easy and hygienic manner.

[0404] The preferred cosmetic method according to the invention further includes the step of applying an applicator to a keratin substance without supplying a cosmetic composition to the microneedles on the application surface of the applicator.

[0405] If the applicator is in roller form, the applicator with microneedles can be applied to the keratin material by rolling it over it. For example, the applicator can be rolled back and forth over the keratin material. The number of cycles will depend on various factors, such as the sensitivity of the keratin material and the cosmetic composition to be used in conjunction with the microneedles. In an embodiment, the back-and-forth motion can be repeated 4 or 5 times, which may take about 1 minute if the keratin material is facial skin.

[0406] The above movements can be performed by the user using a device equipped with an applicator.

[0407] Therefore, the microneedles in microneedles can penetrate into keratinous material to provide cosmetic effects.

[0408] Preferably, the additional step of applying the applicator to the keratin material without supplying the cosmetic composition on the microneedles on the application surface of the applicator is performed before the step of applying the applicator to the keratin material and supplying the cosmetic composition on the microneedles on the application surface of the applicator, because the surface structure of the keratin material can be altered (e.g., more pores / holes can be formed) to accept more cosmetic composition.

[0409] Example

[0410] The invention will be described in more detail by way of examples. However, these examples should not be construed as limiting the scope of the invention. The following examples are presented as non-limiting illustrations within the field of the invention.

[0411] Microneedle patches

[0412] Microneedle sheets were prepared from hyaluronic acid and trehalose. Each microneedle sheet had multiple microneedles on a substrate. Each microneedle had a pyramidal shape and a length or height of 250 μm. The microneedle sheets were diced to form a patch shape with dimensions of 8 cm × 2 cm.

[0413] [Device]

[0414] The following apparatus is provided: it comprises an applicator (with an application surface), a container containing 1% by weight of an aqueous solution of hyaluronic acid (MW: 20-50 kDa) labeled with a fluorescent dye, and a rotary valve. The applicator, container, and valve, as shown in Figures 3A and 3B, are configured to supply the solution to the application surface of the applicator via the valve, and the valve is capable of controlling the supply of solution to the application surface of the applicator. The applicator is in the form of a cylindrical roller. Therefore, the side of the cylindrical roller serves as the application surface. The dimensions of the application surface are 8 cm × 2 cm.

[0415] [Microneedle Components]

[0416] Microneedle patches are attached to the application surface of an applicator in the form of a cylindrical roller to prepare microneedle assemblies. The applicator, container, and rotary valve are configured to supply fluorescent hyaluronic acid aqueous solution to the microneedle patches, such that the valve can control the supply of solution to the microneedle patches.

[0417] [evaluate]

[0418] (Resurfacing effect)

[0419] Skin from the same donor cadaver was cut into slices, each measuring 8 cm x 2 cm. These slices were then divided into two groups: a treatment group and a control group.

[0420] For the treatment group, the skin was treated with a microneedle assembly, whereby the microneedle patch was brought into contact with the skin 10 times by moving a cylindrical roller-like applicator back and forth in one direction across the skin. The valve was in its "closed" position. Therefore, no fluorescent hyaluronic acid aqueous solution was provided on the microneedle patch.

[0421] In the control group, the skin was not treated with microneedles.

[0422] Then, a 0.5 cm x 0.5 cm area was cut from each piece of skin to prepare a sample, and the surface of each sample was observed using a microscope (SEM).

[0423] Comparative analysis revealed that, compared to the control group, the treated group's skin exhibited a greater array pattern in its morphology due to the microneedles passing through it. This demonstrates the successful and highly effective skin rejuvenation effect achieved through the treatment of this invention.

[0424] (Penetration enhancement effect)

[0425] Skin from the same donor cadaver was cut into slices, each measuring 8 cm x 2 cm. These slices were then divided into two groups: a treatment group and a control group.

[0426] For the treatment group, the skin was treated with a microneedle assembly, whereby the microneedle patch was brought into contact with the skin 10 times by moving a cylindrical roller-like applicator back and forth in one direction across the skin. The valve was in its "closed" position. Therefore, no fluorescent hyaluronic acid aqueous solution was provided on the microneedle patch.

[0427] Then, the same steps are repeated, provided that the valve is in its "open" position, so that fluorescent hyaluronic acid aqueous solution is provided on the microneedle patch.

[0428] In the control group, the skin was treated simply by applying a fluorescent hyaluronic acid aqueous solution to the skin without applying the microneedle components.

[0429] After 15 minutes, a 0.5 cm x 1 cm area was cut from each piece of skin to prepare a block. The blocks were treated with an OCT compound and then frozen with liquid nitrogen. The blocks were then cut into 15 μm thick samples using a Cryostat. The cross-section of each sample was observed using a microscope (laser confocal fluorescence microscopy).

[0430] Comparative analysis revealed that, compared to the control group, the fluorescent hyaluronic acid in the treated group penetrated much deeper into the skin. In the control group, the fluorescent hyaluronic acid only penetrated to a very shallow surface of the skin. This demonstrates that the treatment of this invention can enhance the penetration of hyaluronic acid into the skin.

[0431] (Change in microneedle shape)

[0432] In the above treatments used to evaluate the penetration enhancement effect, for the treatment group, the shape of the microneedles was observed under a microscope before and after the application of the microneedle patch with fluorescent hyaluronic acid aqueous solution.

[0433] After co-application of the fluorescent hyaluronic acid aqueous solution, the microneedles became shorter and blunter. This demonstrates that the fluorescent hyaluronic acid aqueous solution was indeed supplied from the container to the microneedle patch to dissolve the microneedles.

[0434] Because of the change in the shape of the microneedles, it is impossible to reuse the microneedle patch.

Claims

1. A beauty care kit for skin, lips, and scalp, comprising: At least one microneedle sheet (1) comprising a substrate layer (1-2) and a plurality of microneedles (1-1) on the substrate layer (1-2), wherein the microneedles (1-1) comprise at least one water-soluble or water-dispersible polymer; and At least one device (2) comprising at least one applicator (2-3), at least one container (2-1), and at least one valve (2-2), said applicator comprising at least one application surface, and said container (2-1) containing at least one cosmetic composition. in The microneedle sheet (1) can be connected to the applicator (2-3) by connecting the substrate layer (1-2) of the microneedle sheet (1) to the application surface of the applicator (2-3). The applicator (2-3), the container (2-1), and the valve (2-2) are configured to supply the cosmetic composition to the microneedle sheet (1) connected to the applicator (2-3) via the valve (2-2) during use of the microneedle sheet (1), and The valve (2-2) is capable of controlling the supply of the cosmetic composition to the microneedle sheet (1) connected to the applicator (2-3), characterized in that, The container (2-1) is in the form of a hollow cylinder with an opening (2-1-1) at an eccentric position on its top surface, and the valve (2-2) includes a rotating disk (2-2-2) having at least one eccentric through hole (2-2-1) that connects to the opening (2-1-1) of the container (2-1) to discharge a cosmetic composition from the opening (2-1-1) and the eccentric through hole (2-2-1) during use of the microneedle sheet (1).

2. The kit according to claim 1, wherein the substrate layer (1-2) of the microneedle sheet (1) is detachable from the application surface of the applicator (2-3) after being attached to the application surface of the applicator (2-3).

3. The kit according to claim 1, wherein the microneedle sheet (1) comprises at least one base layer (1-3), and the base layer (1-3) is fixed on the substrate layer (1-2).

4. The kit according to claim 1, wherein the microneedle sheet (1) includes at least one adhesive layer (1-4), and the adhesive layer (1-4) is fixed on the substrate layer (1-2).

5. The kit according to claim 3, wherein the microneedle sheet (1) includes at least one adhesive layer (1-4), and the adhesive layer (1-4) is fixed on the base layer (1-3).

6. The kit according to claim 4 or 5, wherein the microneedle sheet (1) includes at least one anti-adhesive layer (1-5), and the anti-adhesive layer (1-5) is located on the adhesive layer (1-4).

7. The kit of claim 1, wherein the microneedles (1-1) have a height of 50 to 1000 micrometers.

8. The kit according to claim 1, wherein the application surface of the applicator (2-3) is curved.

9. The kit of claim 8, wherein the applicator (2-3) comprises at least one cylindrical roller having a curved end face, and the curved end face of the cylindrical roller constitutes the application surface.

10. The kit according to claim 1, further comprising at least one housing (4) wherein the housing (4) is capable of storing the microneedle sheet (1).

11. The kit according to claim 10, wherein the housing (4) comprises at least one soft and / or porous article.

12. The kit according to claim 1, wherein the valve (2-2) is a gate valve.

13. The kit of claim 1, wherein the cosmetic composition comprises at least one cosmetic active ingredient.

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