Microfluidic Chip for Drug Delivery System

Abstract

The present application relates to a microfluidic chip for a drug delivery system, which comprises a bottom chip, a top chip and a sealing film; the bottom chip is provided with a mounting groove, and a protruding portion protrudes from the bottom wall of the bottom chip where the mounting groove is located; a flow channel for fluid flow is provided on the protruding portion, and the flow channel comprises a mixing flow channel and a plurality of liquid inlet flow channels. The liquid inlet ends of the plurality of liquid inlet flow channels are arranged at intervals, and the liquid outlet ends of the plurality of liquid inlet flow channels all converge with the mixing flow channel; the top chip is mounted on the bottom chip, and a clamping portion located in the mounting groove protrudes from the side of the top chip facing the bottom chip; the sealing film is clamped between the protruding portion and the clamping portion to seal the flow channel. The present application helps to clamp the sealing film, reduce the possibility of the sealing film moving, and enhance the sealing performance of the sealing film on the flow channel.

Description

Technical Field

[0001] This application relates to the technical field of microfluidic chips, and particularly to a microfluidic chip for a drug delivery system. Background Art

[0002] Microfluidic chip technology is a technology based on the theory of hydrodynamics, which integrates basic operation units such as sample preparation, reaction, separation, and detection in the processes of biological, chemical, and medical analysis onto a chip with a micron scale, and automatically completes the entire analysis process. Due to its great potential in the fields of biology, chemistry, medicine, etc., it has developed into a brand-new research field that intersects multiple disciplines such as biology, chemistry, medicine, fluid, electronics, materials, and machinery.

[0003] The usual chip structure is made by laminating multiple layers of glass or acrylic, and microchannels are engraved in the middle layer. This method has a high cost and cannot achieve mass production. In order to achieve mass production, the current method is to fabricate a smooth bottom chip and a top chip, engrave channels on the bottom chip, laminate a sealing film between the bottom chip and the top chip, and press them tightly. In this way, the sealing performance of the microfluidic chip mainly relies on the top chip pressing the sealing film tightly to make the sealing film seal the channels, but it is difficult to accurately match the sealing film with the channels, resulting in insufficient airtightness. Summary of the Invention

[0004] In order to improve the sealing performance of the microfluidic chip, this application provides a microfluidic chip for a drug delivery system.

[0005] The microfluidic chip for a drug delivery system provided by this application adopts the following technical solutions:

[0006] A microfluidic chip for a drug delivery system, comprising:

[0007] A bottom chip, the bottom chip is provided with a mounting groove, and a protruding portion protrudes from the bottom wall of the mounting groove; a flow channel for fluid flow is provided on the protruding portion, the flow channel includes a mixing channel and a plurality of liquid inlet channels, the liquid inlet ends of the plurality of liquid inlet channels are arranged at intervals, and the liquid outlet ends of the plurality of liquid inlet channels all converge with the mixing channel;

[0008] A top chip, mounted on the bottom chip, a clamping portion protrudes from the side of the top chip facing the bottom chip, and the clamping portion is located in the mounting groove; and,

[0009] A sealing film, the sealing film is clamped between the protruding portion and the clamping portion to seal the flow channel.

[0010] By adopting the above technical solution, the bottom chip is provided with an installation groove, and the top chip is provided with a clamping portion located in the installation groove, which is convenient for positioning the installation position of the top chip; a protruding portion is provided on the bottom chip, and the flow channel is arranged on the protruding portion, so that when the sealing film is placed between the bottom chip and the top chip, the protruding portion on the bottom chip and the clamping portion on the top chip can press the sealing film; relative to the surfaces of the bottom chip and the top chip facing the sealing film are both flat, a protruding portion is provided on the bottom chip, and a clamping portion is provided on the top chip, which helps to clamp the sealing film, reduce the possibility of the sealing film moving, and enhance the sealing performance of the sealing film on the flow channel.

[0011] Optionally, a plurality of annular mixing grooves are concavely provided in the mixing flow channel, and the plurality of annular mixing grooves are spaced apart and sequentially communicated in the direction of the mixing flow channel, and are staggered in the direction perpendicular to the mixing flow channel.

[0012] By adopting the above technical solution, the fluid flows into the mixing flow channel through the liquid inlet flow channel for mixing, and the mixed fluid is mixed again after being split by the annular mixing grooves, which can promote more uniform mixing of the fluid.

[0013] Optionally, the mixing flow channel is arranged in a curved shape.

[0014] By adopting the above technical solution, increasing the length of the mixing flow channel, on the one hand, can extend the reaction time between fluids, ensure that the reaction between fluids occurs completely in the flow channel, and make the product flowing out of the mixing flow channel be the reacted finished product; on the other hand, it reduces the flow rate of the fluid in the mixing flow channel, playing a role in pressure relief, so that the finished product flows out smoothly from the mixing flow channel.

[0015] Optionally, the length of at least one of the liquid inlet flow channels is different from the lengths of the other liquid inlet flow channels, and the liquid inlet flow channel with a larger length is arranged in a curved shape.

[0016] By adopting the above technical solution, the fluid with a larger flow rate can be injected into the liquid inlet flow channel with a larger length, and the fluid with a smaller flow rate can be injected into the liquid inlet flow channel with a smaller length, so that different fluids flow to the mixing flow channel at the same time, reducing the phenomenon of cross-contamination of fluids during liquid inlet.

[0017] Optionally, the materials of the bottom chip and the top chip are stainless steel.

[0018] By adopting the above technical solution, the bottom chip and the top chip made of stainless steel will not react with the fluid, can carry fluids with a larger flow rate, and realize a pilot-scale microfluidic chip.

[0019] Optionally, a plurality of liquid inlet ports in one-to-one communication with the liquid inlet end and a liquid outlet port in communication with the liquid outlet end are provided on the outer peripheral surface of the bottom chip.

[0020] By adopting the above technical solution, both the liquid inlet and the liquid outlet are connected to the pipeline. The liquid inlet and the liquid outlet are located on the outer peripheral surface of the bottom chip, which can avoid affecting the placement of the bottom chip and the sealing performance of the sealing film, and ensure the stability of the reaction occurring inside the chip.

[0021] Optionally, a plurality of milling channels are convexly provided on the bottom wall of the mounting groove of the bottom chip. The plurality of milling channels are spaced apart and arranged around the flow channel. The milling channel close to the flow channel is parallel to the flow channel, and the milling channel close to the inner side wall of the mounting groove of the bottom chip is parallel to the inner side wall. The top of the milling channel and the clamping portion jointly clamp the sealing film.

[0022] By adopting the above technical solution, the mounting groove on the bottom chip can be formed by milling. While machining the mounting groove, milling channels can be reserved on the bottom chip. The milling channels and the clamping portion clamp the sealing film, which can further help to clamp the sealing film, reduce the possibility of the sealing film moving, and enhance the sealing performance of the sealing film to the flow channel. The milling channel close to the flow channel is parallel to the flow channel, and the milling channel close to the inner side wall is parallel to the inner side wall, so that the milling channel close to the flow channel can be spliced with the milling channel close to the inner side wall, which can improve the machining efficiency of the milling channels on the bottom chip.

[0023] Optionally, there are two liquid inlet channels, and the two liquid inlet channels converge at the end point of the mixing channel.

[0024] By adopting the above technical solution, an aqueous phase is injected into one liquid inlet channel, and an organic phase is injected into the other liquid inlet channel. The self-assembly reaction can occur when the aqueous phase and the organic phase converge at the end of the mixing channel.

[0025] Optionally, the included angle at the intersection of the two liquid inlet channels is less than or equal to 90°.

[0026] By adopting the above technical solution, when injecting fluid into one liquid inlet channel, the fluid does not have a flow component flowing towards the other liquid inlet channel, reducing the phenomenon of cross-contamination of the fluid during liquid inlet.

[0027] Optionally, the liquid inlet channel includes a first liquid inlet channel and a second liquid inlet channel. The depth of the first liquid inlet channel is greater than the depth of the second liquid inlet channel. A seal strip protruding towards the bottom chip is formed at the position of the top chip opposite to the first liquid inlet channel and extends into the upper part of the first liquid inlet channel to seal the upper part of the first liquid inlet channel. The thickness of the seal strip is the same as the depth of the second liquid inlet channel, and the depth of one end of the mixing channel close to the liquid inlet channel is the same as the depth of the first liquid inlet channel.

[0028] By adopting the above technical solution, the fluid flowing in the first liquid inlet channel is the first fluid, and the fluid flowing in the second liquid inlet channel is the second fluid. The first fluid flows at the bottom of the first liquid inlet channel, and the second fluid is located above the first fluid. When the first fluid and the second fluid flow to the mixing channel, the second fluid is mixed with the first fluid under the action of gravity, and the mixing effect can be improved during the flow of the first fluid and the second fluid. At the same time, the depth of the end of the mixing channel is the same as the depth of the first liquid inlet channel, so that the end of the mixing channel can completely accommodate the incoming first fluid and second fluid, and the first fluid and the second fluid will not be squeezed when they meet, thereby reducing the phenomenon of cross-contamination of the fluid during liquid inlet.

[0029] Optionally, the mixing channel sequentially includes a first channel, a second channel, and a third channel along the flow direction. The depth of the first channel is the same as that of the first liquid inlet channel. The depth of the third channel is smaller than that of the first channel. The second channel is located between the first channel and the third channel. In the direction from the first channel to the third channel, the depth of the second channel gradually decreases from the same as that of the first channel to the same as that of the third channel.

[0030] By adopting the above technical solution, the first fluid and the second fluid gradually flow to the third channel after confluence. Under the squeezing action of the second channel and the third channel, the mixing of the first fluid and the second fluid can be further promoted.

[0031] Optionally, a Tesla valve is provided on the second channel.

[0032] By adopting the above technical solution, the first fluid and the second fluid will be squeezed when flowing to the second channel. By providing a Tesla valve on the second channel, the mixed fluid can be prevented from flowing back to the first channel, avoiding the generation of a flow component towards the first liquid inlet channel or the second liquid inlet channel, thereby reducing the phenomenon of cross-contamination of the fluid during liquid inlet.

[0033] Optionally, a fourth channel is provided between the second channel and the third channel. The depth of the fourth channel is larger than that of the third channel. The bottom wall of the fourth channel of the bottom chip protrudes towards the top chip to form a plurality of first protrusions arranged at intervals. The distance between the first protrusion and the top chip is the same as the depth of the third channel. The top chip protrudes towards the bottom chip to form a plurality of second protrusions arranged at intervals. The distance between the second protrusion and the bottom wall of the fourth channel of the bottom chip is the same as the depth of the third channel. The first protrusions and the second protrusions are alternately arranged in the direction of the fourth channel and partially overlap in the projection in the direction of the fourth channel. The distance between the first protrusions and the second protrusions in the direction of the fourth channel is the same as the depth of the third channel.

[0034] By adopting the above technical solution, a serpentine flow channel with undulations up and down is formed in the fourth flow channel, which can promote more uniform mixing of the fluid.

[0035] In summary, the present application includes at least one of the following beneficial technical effects:

[0036] 1. The bottom chip is provided with an installation groove, and the top chip is provided with a clamping portion located in the installation groove, which is convenient for positioning the installation position of the top chip; the sealing film is placed between the bottom chip and the top chip, and the protruding portion on the bottom chip and the clamping portion on the top chip can press the sealing film tightly, which helps to clamp the sealing film, reduce the possibility of the sealing film moving, and enhance the sealing performance of the sealing film for the flow channel.

[0037] 2. The fluid flows into the mixing flow channel through the liquid inlet flow channel for mixing, and the mixed fluid is mixed again after being split by the annular mixing groove, which can promote more uniform mixing of the fluid.

[0038] 3. There are two liquid inlet flow channels, and the included angle formed between the ends of the two liquid inlet flow channels close to the mixing flow channel is less than or equal to 90°, reducing the phenomenon of cross-contamination of the fluid during liquid inlet.

[0039] 4. The depth of the first liquid inlet flow channel is greater than the depth of the second liquid inlet flow channel. The first fluid flows at the bottom of the first liquid inlet flow channel, and the second fluid is located above the first fluid. When the first fluid and the second fluid flow to the mixing flow channel, the second fluid mixes with the first fluid under the action of gravity, and the mixing effect can be improved during the flow of the first fluid and the second fluid. The depth of the end of the mixing flow channel is the same as the depth of the first liquid inlet flow channel, so that the end of the mixing flow channel can completely accommodate the flowing-in first fluid and second fluid, and the first fluid and the second fluid will not be squeezed when they meet, thereby reducing the phenomenon of cross-contamination of the fluid during liquid inlet. Description of the Drawings

[0040] Figure 1 is a schematic structural diagram of the microfluidic chip for the drug delivery system in Embodiment 1 of the present application;

[0041] Figure 2 is Figure 1 a top view schematic diagram of the bottom chip in

[0042] Figure 3 is Figure 1 a schematic structural diagram of the top chip in

[0043] Figure 4 is a top view schematic diagram of the bottom chip in the microfluidic chip for the drug delivery system in Embodiment 2 of the present application;

[0044] Figure 5 is Figure 4Schematic cross-sectional view along A-A’ in [the figure];

[0045] Figure 6 is Figure 4 Schematic cross-sectional view along B-B’ in [the figure];

[0046] Figure 7 is Figure 6 Schematic enlarged view of the local part at D in [the figure];

[0047] Figure 8 is Figure 4 Schematic enlarged view of the local part at C in [the figure];

[0048] Figure 9 is Figure 4 Schematic cross-sectional view of the mixing channel in [the figure];

[0049] Figure 10 is the schematic cross-sectional view of the mixing channel in the microfluidic chip for the drug delivery system in Example 3 of the present application;

[0050] Figure 11 is Figure 10 Schematic enlarged view of the local part at E in [the figure];

[0051] Figure 12 is the schematic top view of the bottom chip in the microfluidic chip for the drug delivery system in Example 4 of the present application;

[0052] Figure 13 is Figure 12 Schematic cross-sectional view along F-F’ in [the figure].

[0053] Explanation of reference numerals: 1. Bottom chip; 11. Mounting groove; 12. Protrusion; 13. Liquid inlet; 14. Liquid outlet; 15. First protrusion; 16. Milling channel; 2. Top chip; 21. Clamping part; 22. Seal strip; 23. Second protrusion; 3. Sealing film; 4. Channel; 41. Mixing channel; 41a. Annular mixing groove; 411. First channel; 412. Second channel; 413. Third channel; 414. Fourth channel; 42. Liquid inlet channel; 42a. First liquid inlet channel; 42b. Second liquid inlet channel; 43. Tesla valve. Detailed implementation manners

[0054] The following further elaborates on the present application in conjunction with the attached Figure 1-13 drawings.

[0055] The embodiment of the present application discloses a microfluidic chip for a drug delivery system.

[0056] Referring to Figure 1 , the microfluidic chip for a drug delivery system includes a bottom chip 1, a top chip 2, and a sealing film 3. The bottom chip 1 is provided with a mounting groove 11, the bottom wall of the mounting groove 11 protrudes with a protrusion 12, and a channel 4 for fluid flow is provided on the protrusion 12. Referring toFigure 2 The flow channel 4 includes a mixing flow channel 41 and a plurality of liquid inlet flow channels 42. The liquid inlet ends of the plurality of liquid inlet flow channels 42 are arranged at intervals. The liquid outlet ends of the plurality of liquid inlet flow channels 42 all converge with the mixing flow channel 41. The number of liquid inlet channels can be two or more than three, specifically set according to the number of fluids undergoing the reaction. The positions where each liquid inlet flow channel 42 converges with the mixing flow channel 41 can be the same or different, specifically set according to the reaction sequence.

[0057] The top chip 2 is installed on the bottom chip 1, referring to Figure 3 One side of the top chip 2 facing the bottom chip 1 is convexly provided with a clamping portion 21, and the clamping portion 21 is located in the installation groove 11. The sealing film 3 is clamped between the bottom chip 1 and the top chip 2 to seal the flow channel 4. The bottom chip 1 and the top chip 2 can be connected by bolts, adhesives, snap connections, welding and other methods.

[0058] The bottom chip 1 is provided with an installation groove 11, and the top chip 2 is provided with a clamping portion 21 located in the installation groove 11, which is convenient for positioning the installation position of the top chip 2; a protruding portion 12 is provided on the bottom chip 1, and the flow channel 4 is arranged on the protruding portion 12, so that when the sealing film 3 is placed between the bottom chip 1 and the top chip 2, the protruding portion 12 on the bottom chip 1 and the clamping portion 21 on the top chip 2 can press the sealing film 3; the sealing film 3 covers the flow channel 4 to seal the flow channel 4. Fluids participating in the reaction are injected into the plurality of liquid inlet flow channels 42, and the fluids converge and react in the mixing flow channel 41, and the reaction products flow out from the mixing flow channel 41. Relative to the surfaces of the bottom chip 1 and the top chip 2 facing the sealing film 3, they are both flat. Providing the protruding portion 12 on the bottom chip 1 and the clamping portion 21 on the top chip 2 helps to clamp the sealing film 3, reduce the possibility of the sealing film 3 moving, and enhance the sealing performance of the sealing film 3 for the flow channel 4.

[0059] Embodiment 1

[0060] Referring to Figure 2 In this embodiment, there are two liquid inlet flow channels 42, and the two liquid inlet flow channels 42 are the first liquid inlet flow channel 42a and the second liquid inlet flow channel 42b. The two liquid inlet flow channels 42 converge at the end point of the mixing flow channel 41. One liquid inlet flow channel 42 injects the aqueous phase, and the other liquid inlet flow channel 42 injects the organic phase. The self-assembly reaction can occur when the aqueous phase and the organic phase converge at the end of the mixing flow channel 41.

[0061] In order to avoid affecting the sealing performance of the sealing film 3, referring to Figure 1, the bottom chip 1 is provided with a plurality of liquid inlets 13 respectively communicating with the liquid inlet end and a liquid outlet 14 communicating with the liquid outlet end. The liquid inlets 13 are connected to a plunger pump or a syringe through a conduit. Preferably, the liquid inlets 13 and the liquid outlet 14 are arranged on the outer peripheral surface of the bottom chip 1, which can avoid affecting the placement of the bottom chip 1 and ensure the stability of the reaction occurring inside the chip. In other embodiments, the liquid inlets 13 and the liquid outlet 14 can also be arranged on the bottom surface of the bottom chip 1.

[0062] In this embodiment, the liquid inlet 13 is connected to a plunger pump through a conduit to realize a pilot-scale microfluidic chip. Optionally, the materials of the bottom chip 1 and the top chip 2 can be stainless steel, aluminum alloy, etc., as long as they are hard materials that do not react with the fluid and can carry fluids with a greater flow rate. For example, the flow rate of the fluid is above 400 ml / min, and the pressure in the flow channel 4 is above 20 atmospheres.

[0063] In an alternative embodiment, the included angle at the intersection of the two liquid inlet channels 42 is less than or equal to 90°. When injecting fluid into one of the liquid inlet channels 42, the fluid does not have a flow component flowing towards the other liquid inlet channel 42, reducing the phenomenon of cross-contamination of the fluid during liquid inlet.

[0064] When injecting fluid, it is necessary to try to make the two fluids flow to the mixing channel 41 for collection at the same time. On the one hand, it can reduce the waste of fluid, and on the other hand, it can reduce the phenomenon of fluid contamination caused by the fluid in one liquid inlet channel 42 entering another liquid inlet channel 42.

[0065] Each liquid inlet channel 42 can be linear, or curved such as arc-shaped or serpentine. In an alternative embodiment, the length of at least one liquid inlet channel 42 is different from that of the other liquid inlet channels 42. The liquid inlet channel 42 with a larger length is arranged in a curved shape, which can reduce the size of the microfluidic chip. Specifically, the length of the second liquid inlet channel 42b is larger than that of the first liquid inlet channel 42a. Inject the fluid with a larger flow rate into the liquid inlet channel 42 with a larger length, and inject the fluid with a smaller flow rate into the liquid inlet channel 42 with a smaller length, so that different fluids flow to the mixing channel 41 at the same time, reducing the phenomenon of cross-contamination of the fluid during liquid inlet.

[0066] The mixing channel 41 is arranged in a curved shape to increase the length of the mixing channel 41. On the one hand, it can extend the reaction time between fluids, ensure that the reaction between fluids occurs completely in the flow channel 4, and make the product flowing out of the mixing channel 41 be the reacted finished product; on the other hand, it reduces the flow rate of the fluid in the mixing channel 41, playing a pressure relief role, so that the finished product flows out smoothly from the mixing channel 41.

[0067] In order to improve the mixing degree between fluids and promote the complete reaction of fluids, refer to Figure 2, the mixed flow channel 41 is concavely provided with a plurality of annular mixing grooves 41a. The plurality of annular mixing grooves 41a are spaced along the direction of the mixed flow channel 41 and are sequentially connected, and are staggered in the direction perpendicular to the mixed flow channel 41. The fluid flows into the mixed flow channel 41 through the liquid inlet flow channel 42 for mixing. After the mixed fluid is shunted by the annular mixing grooves 41a and then mixed again, it can promote the fluid to be mixed more evenly.

[0068] The implementation principle of the microfluidic chip for a drug delivery system in an embodiment of the present application is as follows:

[0069] Place the sealing film 3 between the top chip 2 and the bottom chip 1, connect the top chip 2 and the bottom chip 1. The protruding part 12 on the bottom chip 1 and the clamping part 21 on the top chip 2 clamp the sealing film 3 to realize the sealing of the flow channel 4 by the sealing film 3. The fluids to be injected are the aqueous phase and the organic phase. A fluid with a relatively large flow rate is injected into the second liquid inlet flow channel 42b through a plunger pump, and a fluid with a relatively small flow rate is injected into the first liquid inlet flow channel 42a, so that the aqueous phase and the organic phase converge at the end of the mixed flow channel 41 at the same time, and the self-assembly reaction starts. By providing the annular mixing grooves 41a, after the fluid forms a laminar flow through multiple restrictions, the mixing and reaction speed and uniformity of the aqueous phase and the organic phase can be controlled, and the uniformity and consistency of the product can be improved.

[0070] Example 2

[0071] The difference between Example 2 and Example 1 is that the widths of each position in the flow channel 4 in the direction perpendicular to the direction of the flow channel 4 are the same. That is, when the depths of two positions in the flow channel 4 are the same, the cross-sections of these two positions are the same; the greater the depth, the larger the cross-section, and the more fluid can pass through at the same time.

[0072] Refer to Figure 4 , the depth of the first liquid inlet flow channel 42a is greater than the depth of the second liquid inlet flow channel 42b. Refer to Figure 5 and Figure 6 , Figure 5 is Figure 4 The schematic cross-sectional view of A-A' in Figure 6 is Figure 4 The schematic cross-sectional view of B-B' in Figure 7 ). To seal the upper part of the first liquid inlet flow channel 42a, the thickness of the seal 22 is the same as the depth of the second liquid inlet flow channel 42b. The position of the sealing film 3 opposite to the seal 22 is bent to be adapted to the seal 22. The depth of one end of the mixed flow channel 41 close to the liquid inlet flow channel 42 is the same as the depth of the first liquid inlet flow channel 42a.

[0073] The fluid flowing in the first liquid inlet channel 42a is the first fluid, and the fluid flowing in the second liquid inlet channel 42b is the second fluid. The first fluid flows at the bottom of the first liquid inlet channel 42a, and the second fluid is located above the first fluid. When the first fluid and the second fluid flow to the mixing channel 41, the second fluid mixes with the first fluid under the action of gravity, and the mixing effect of the first fluid and the second fluid can be improved during the flow. At the same time, the depth of the end of the mixing channel 41 is the same as the depth of the first liquid inlet channel 42a, so that the end of the mixing channel 41 can completely accommodate the first fluid and the second fluid flowing in, and the first fluid and the second fluid will not be squeezed when they meet, thereby reducing the phenomenon of cross contamination of the fluid during liquid inlet.

[0074] Further, refer to Figure 8 In an optional embodiment, the mixing channel 41 includes a first channel 411, a second channel 412 and a third channel 413 in sequence along the flow direction, referring to Figure 9 The first flow channel 411 has the same depth as the first liquid inlet flow channel 42a, the depth of the third flow channel 413 is smaller than the depth of the first flow channel 411, and the second flow channel 412 is located between the first flow channel 411 and the third flow channel 413. In the direction from the first flow channel 411 to the third flow channel 413, the depth of the second flow channel 412 gradually decreases from the same depth as the first flow channel 411 to the same depth as the third flow channel 413.

[0075] After the first fluid and the second fluid merge, they gradually flow to the third flow channel 413 . The squeezing effect of the second flow channel 412 and the third flow channel 413 can further promote the mixing of the first fluid and the second fluid.

[0076] In an alternative embodiment, referring to Figure 8 A Tesla valve 43 is provided on the second flow channel 412. The first fluid and the second fluid will be squeezed when flowing to the second flow channel 412. The Tesla valve 43 is provided on the second flow channel 412 to prevent the mixed fluid from flowing back to the first flow channel 411, avoiding the generation of a flow component toward the first liquid inlet flow channel 42a or the second liquid inlet flow channel 42b, thereby reducing the phenomenon of cross contamination of the fluid during liquid inlet.

[0077] The implementation principle of a microfluidic chip for a drug delivery system in the present application embodiment is as follows:

[0078] The first fluid flows in the first liquid inlet channel 42a, and the second fluid flows in the second liquid inlet channel 42b. When the first fluid and the second fluid converge in the mixing channel 41, since the depth of the first fluid is greater than that of the second fluid, the second fluid mixes with the first fluid under the action of gravity, and the mixing effect can be improved during the flow of the first fluid and the second fluid, while reducing the phenomenon of cross-contamination of the fluid during liquid inlet. When the mixed fluid flows through the second channel 412, since the depth of the mixing channel 41 gradually becomes smaller, the mixing degree of the fluid can be further promoted. A Tesla valve 43 is provided on the second channel 412 to prevent the backflow of the mixed fluid when it is squeezed.

[0079] Embodiment 3

[0080] Refer to Figure 10 and Figure 11 In Embodiment 3, the difference from Embodiment 2 is that a fourth channel 414 is provided between the second channel 412 and the third channel 413. The depth of the fourth channel 414 is greater than that of the third channel 413. A bottom wall of the fourth channel 414 of the bottom chip 1 protrudes toward the top chip 2 to form a plurality of first protrusions 15 arranged at intervals. The distance a between the first protrusions 15 and the top chip 2 is the same as the depth of the third channel 413. The top chip 2 protrudes toward the bottom chip 1 to form a plurality of second protrusions 23 arranged at intervals. The sealing film 3 is bent at a position opposite to the second protrusions 23 to be adapted to the second protrusions 23. The distance b between the second protrusions 23 and the bottom wall of the bottom chip 1 provided with the fourth channel 414 is the same as the depth of the third channel 413. The first protrusions 15 and the second protrusions 23 are alternately arranged in the direction of the fourth channel 414 and partially overlap in the projection in the direction of the fourth channel 414. The distance c between the first protrusions 15 and the second protrusions 23 in the direction of the fourth channel 414 is the same as the depth of the third channel 413.

[0081] The implementation principle of the microfluidic chip for a drug delivery system in the embodiment of the present application is as follows:

[0082] The fluid flows in the mixing channel 41 to the fourth channel 414. Since the fluid is injected by a plunger pump, a relatively large pressure is generated inside the fluid. Even if there are the first protrusions 15 and the second protrusions 23 with a blocking effect in the fourth channel 414, the fluid can flow along the undulating serpentine flow channel under the pressure of the plunger pump. When the fluid drops from the channel above the first protrusions 15 to the channel below the second protrusions 23, the fluid surges under the action of gravity, which can promote the more uniform mixing of the fluid.

[0083] Embodiment 4

[0084] Refer to Figure 12 and Figure 13, the difference between Embodiment 4 and Embodiment 1 is that a plurality of milling channels 16 protrude from the bottom wall of the mounting groove 11 provided on the bottom chip 1. The plurality of milling channels 16 are spaced apart and arranged around the flow channel 4. The milling channel 16 close to the flow channel 4 is parallel to the flow channel 4, and the milling channel 16 close to the inner side wall of the mounting groove 11 provided on the bottom chip 1 is parallel to the inner side wall. The top of the milling channel 16 and the clamping portion 21 jointly clamp the sealing film 3.

[0085] The mounting groove 11 on the bottom chip 1 can be formed by milling. While machining the mounting groove 11, the milling channels 16 can be reserved on the bottom chip 1. The milling channels 16 and the clamping portion 21 clamp the sealing film 3, which can further help to clamp the sealing film 3, reduce the possibility of the sealing film 3 moving, and enhance the sealing performance of the sealing film 3 on the flow channel 4. The milling channel 16 close to the flow channel 4 is parallel to the flow channel 4, and the milling channel 16 close to the inner side wall is parallel to the inner side wall, so that the milling channel 16 close to the flow channel 4 can be spliced with the milling channel 16 close to the inner side wall, which can improve the machining efficiency of the milling channels 16 on the bottom chip 1.

[0086] The above are all the preferred embodiments of the present application. The protection scope of the present application is not limited accordingly. Therefore, all equivalent changes made according to the structure, shape, and principle of the present application should be covered within the protection scope of the present application.

Claims

1. A microfluidic chip for a drug delivery system, characterized in that, Comprising: A bottom chip (1), the bottom chip (1) is provided with a mounting groove (11), and a protruding portion (12) protrudes from the bottom wall of the mounting groove (11); a flow channel (4) for fluid flow is provided on the protruding portion (12), and the flow channel (4) includes a mixing flow channel (41) and a plurality of liquid inlet flow channels (42), the liquid inlet ends of the plurality of liquid inlet flow channels (42) are arranged at intervals, and the liquid outlet ends of the plurality of liquid inlet flow channels (42) all converge with the mixing flow channel (41); A top chip (2), mounted on the bottom chip (1), a clamping portion (21) protrudes from the side of the top chip (2) facing the bottom chip (1), and the clamping portion (21) is located in the mounting groove (11); and, A sealing film (3), the sealing film (3) is clamped between the protruding portion (12) and the clamping portion (21) to seal the flow channel (4).

2. The microfluidic chip for a drug delivery system according to claim 1, wherein, A plurality of annular mixing grooves (41a) are recessed in the mixing flow channel (41), the plurality of annular mixing grooves (41a) are arranged at intervals in the running direction of the mixing flow channel (41) and are sequentially communicated, and are arranged staggered in the direction perpendicular to the mixing flow channel (41); and / or, The mixing flow channel (41) is arranged in a curved shape; and / or, The length of at least one of the liquid inlet flow channels (42) is different from that of the other liquid inlet flow channels (42), and the liquid inlet flow channel (42) with a larger length is arranged in a curved shape.

3. The microfluidic chip for a drug delivery system according to claim 1, characterized in that, The materials of the bottom chip (1) and the top chip (2) are stainless steel; and / or, A plurality of liquid inlet ports (13) in one-to-one communication with the liquid inlet ends and a liquid outlet port (14) in communication with the liquid outlet end are provided on the outer peripheral surface of the bottom chip (1).

4. The microfluidic chip for a drug delivery system according to claim 1, characterized in that, A plurality of milling channels (16) protrude from the bottom wall of the mounting groove (11) of the bottom chip (1), the plurality of milling channels (16) are arranged at intervals and surround the flow channel (4), the milling channel (16) close to the flow channel (4) is parallel to the flow channel (4), and the milling channel (16) close to the inner side wall of the bottom chip (1) where the mounting groove (11) is provided is parallel to the inner side wall, and the top of the milling channel (16) and the clamping portion (21) jointly clamp the sealing film (3).

5. The microfluidic chip for a drug delivery system according to claim 1, wherein There are two liquid inlet flow channels (42), and the two liquid inlet flow channels (42) converge at the end point of the mixing flow channel (41).

6. The microfluidic chip for a drug delivery system according to claim 5, wherein The included angle at the intersection of the two liquid inlet flow channels (42) is less than or equal to 90°.

7. The microfluidic chip for a drug delivery system according to claim 5, wherein The liquid inlet channel (42) includes a first liquid inlet channel (42a) and a second liquid inlet channel (42b). The depth of the first liquid inlet channel (42a) is greater than that of the second liquid inlet channel (42b). At a position of the top chip (2) opposite to the first liquid inlet channel (42a), a seal (22) protrudes towards the bottom chip (1) and extends into the upper part of the first liquid inlet channel (42a) to seal the upper part of the first liquid inlet channel (42a). The thickness of the seal (22) is the same as the depth of the second liquid inlet channel (42b). The depth of one end of the mixing channel (41) close to the liquid inlet channel (42) is the same as the depth of the first liquid inlet channel (42a).

8. The microfluidic chip for a drug delivery system according to claim 7, wherein The mixing channel (41) sequentially includes a first channel (411), a second channel (412), and a third channel (413) along the flow direction. The depth of the first channel (411) is the same as that of the first liquid inlet channel (42a). The depth of the third channel (413) is smaller than that of the first channel (411). The second channel (412) is located between the first channel (411) and the third channel (413). In the direction from the first channel (411) to the third channel (413), the depth of the second channel (412) gradually decreases from the same as that of the first channel (411) to the same as that of the third channel (413).

9. The microfluidic chip for a drug delivery system according to claim 8, wherein, A Tesla valve (43) is provided on the second channel (412).

10. The microfluidic chip for a drug delivery system according to claim 8, characterized in that, A fourth channel (414) is provided between the second channel (412) and the third channel (413). The depth of the fourth channel (414) is greater than that of the third channel (413). On the bottom wall of the bottom chip (1) where the fourth channel (414) is provided, a plurality of first protrusions (15) are formed protruding towards the top chip (2) and arranged at intervals. The distance between the first protrusions (15) and the top chip (2) is the same as the depth of the third channel (413). The top chip (2) protrudes towards the bottom chip (1) to form a plurality of second protrusions (23) arranged at intervals. The distance between the second protrusions (23) and the bottom wall of the bottom chip (1) where the fourth channel (414) is provided is the same as the depth of the third channel (413). The first protrusions (15) and the second protrusions (23) are alternately arranged in the direction of the fourth channel (414) and partially overlap in the projection in the direction of the fourth channel (414). The distance between the first protrusions (15) and the second protrusions (23) in the direction of the fourth channel (414) is the same as the depth of the third channel (413).

Images