Thrombectomy device and its front end device

Abstract

The application relates to the embolus treatment technical field, discloses a kind of embolus extractor and its front end device, front end device can pass through the lumen of blood vessel, and move in blood vessel, front end device includes capillary catheter, wire loop structure and guide wire, wire loop of wire loop structure is around capillary catheter and is fixed on capillary catheter, when embolus is extracted, can pass through alternating electromagnetic wave or alternating current to act on wire loop structure and make wire loop structure act on embolus to improve the hardness or strength of embolus, and make embolus more firmly adhere on wire loop structure, thus can be completely extracted, can reduce the fragmentation of embolus.In addition, when moving in blood vessel, the front end device can be stored in microcatheter, and then released when reaching embolus point, which can effectively prevent the abrasion of the front end device to the blood vessel wall.The embolus extractor and embolus extraction control method with the front end device also have the above advantages.

Description

Technical Field

[0001] This application relates to the field of embolic material treatment technology, and in particular to an embolic retrieval device and its front end device. Background Technology

[0002] Interventional treatment techniques are one of the treatment methods for ischemic stroke. For example, the stent-type thrombectomy devices currently available internationally, including the first-generation mechanical thrombectomy device Merci Retriever and the second-generation mechanical thrombectomy devices Trevo and Solitaire, have a certain effect on the removal of emboli. However, due to structural design problems, these thrombectomy devices are prone to causing wear and tear on the blood vessel wall during the thrombectomy process, which can lead to damage to the blood vessel wall and bleeding. Alternatively, the stent may be over-embedded in the thrombus, causing the thrombus to fragment and produce secondary thrombi that break off and enter smaller downstream blood vessels, causing distal embolism again. Summary of the Invention

[0003] This application aims to at least address one of the technical problems existing in the prior art. To this end, this application proposes a front-end device that can reduce wear and tear on the blood vessel wall and reduce fragmentation of emboli.

[0004] This application also proposes a thrombectomy device with the front end device, and a method for controlling the acquisition and removal of emboli.

[0005] According to an embodiment of the first aspect of this application, the front-end device is capable of passing through the lumen of a blood vessel and moving within the blood vessel. The front-end device includes a capillary catheter, a loop structure, and a guidewire. The capillary catheter has a predetermined length and has a proximal end and a distal end along its length direction. A fixing portion is provided on the capillary catheter. The loop structure includes multiple threads extending from the proximal end to the distal end. Each thread is independent of the others and is adapted to be acted upon by alternating electromagnetic waves or alternating current. Each thread includes a loop section surrounding the capillary catheter, and the loop section is fixed to the fixing portion. The guidewire is disposed at the distal end and connected to one of the threads for guiding the location of an intravascular embolus.

[0006] The front-end device of the first aspect embodiment of this application has at least the following beneficial effects: the thread of the loop structure is suitable for action by alternating electromagnetic waves or alternating current, and the loop section is wrapped around and fixed to the capillary. Therefore, during thrombectomy, after the alternating electromagnetic waves or alternating current act on the thread of the loop structure, the hardness or strength of the embolus in contact with the thread can be enhanced, thereby making the embolus adhere more firmly to the loop structure, thus allowing it to be completely removed and reducing the fragmentation of the embolus. In addition, by removing the embolus in the above manner, the loop structure can be set to a small size, for example, smaller than the diameter of the blood vessel lumen. This effectively avoids abrasion of the blood vessel wall by the device during movement. Alternatively, based on this structure, the front-end device can be housed in a microcatheter with an external size smaller than the lumen during application. Movement within the blood vessel is performed through the microcatheter, and the front-end device is released to perform thrombectomy when the embolus location is reached, which also effectively prevents abrasion of the blood vessel wall by the front-end device.

[0007] According to some embodiments of this application, the capillary tube is hollow to form an inner cavity, the fixing part includes a plurality of pinholes, the plurality of pinholes are spaced apart from the proximal end to the distal end of the capillary tube on the tube wall and communicate with the inner cavity, and the thread passes through the pinholes.

[0008] According to some embodiments of this application, the plurality of pinholes on the capillary tube include multiple groups of pinholes symmetrically arranged on the tube wall of the capillary tube, each group of pinholes being located on different sides of the tube wall, and the pinholes in the same group of pinholes being used to thread the same thread.

[0009] According to some embodiments of this application, the capillary is in the shape of a round tube, and the inner diameter of the capillary ranges from 0.25 mm to 0.35 mm.

[0010] According to some embodiments of this application, each of the threads further includes a connecting segment located in the inner cavity. The connecting segment extends along the length of the capillary. One end of the connecting segment is used to connect to a control device, and the other end is connected to the surrounding segment. The surrounding segment passes through the needle hole and surrounds the capillary. The surrounding segment extends along the length of the capillary and is wound to form at least one loop structure.

[0011] According to some embodiments of this application, the diameter of the annular structure ranges from 1 mm to 3 mm.

[0012] According to some embodiments of this application, the outer surface of the filament is provided with a biocompatible coating and / or a developing coating, wherein the biocompatible coating is made of a biocompatible material and the developing coating is formed by coating the outer surface of the filament with a developing material.

[0013] According to a second aspect of this application, a thrombectomy device includes a front end device, a microcatheter, and an electromagnetic wave generator. The front end device is the same as that described in the first aspect of the application. The microcatheter has a receiving cavity inside, which is used to house the front end device. The electromagnetic wave generator is used to act on the wire of the loop structure by using alternating electromagnetic waves or alternating current.

[0014] The thrombectomy device according to the second aspect of this application has at least the following beneficial effects: Using the front-end device of the first aspect embodiment, the strength or hardness of the embolus can be enhanced by applying alternating electromagnetic waves or alternating current to the thread of the loop structure, thus strengthening the adhesion of the embolus to the loop structure. This allows the embolus to adhere more firmly to the loop structure, enabling complete removal and reducing the fragmentation of the embolus. Furthermore, by housing the front-end device through a microcatheter, the device does not contact the vessel wall during intravascular movement. It is released upon reaching the embolism point for thrombectomy, effectively preventing abrasion of the vessel wall by the front-end device.

[0015] According to some embodiments of this application, the thrombectomy device further includes a camera device for positioning and developing the front end device with a developing coating.

[0016] According to some embodiments of this application, the thrombectomy device further includes a pusher wire, the capillary tube has a hollow interior forming an inner cavity, the pusher wire is housed in the inner cavity and adapted to be connected to a control device, and the pusher wire is in contact with each of the wires.

[0017] According to some embodiments of this application, one end of the push wire is located inside the distal end of the capillary and has a set distance from the circumferential section, while the other end extends from the distal end of the capillary for connection to a control device.

[0018] The embolus removal control method according to a third aspect embodiment of this application includes:

[0019] To determine the location of the embolus within the lumen;

[0020] The microcatheter containing the front-end device is manipulated to enter the lumen and reach the location of the embolus. The front-end device is then released from the microcatheter and the loop structure of the front-end device contacts the embolus.

[0021] Applying alternating electromagnetic waves or alternating current to the loop structure of the front-end device can enhance the hardness or strength of the embolus and strengthen the adhesion of the embolus to the loop structure.

[0022] The front-end device and the emboli adhering to the front-end device are retrieved into the microcatheter;

[0023] Manipulate the microcatheter to move out of the lumen.

[0024] A method for obtaining an embolic material according to a fourth aspect of this application includes: configuring a metal carrier that is movable within the lumen of a blood vessel; applying alternating electromagnetic waves or alternating current to the metal carrier to contact the embolic material, thereby enhancing the strength or hardness of the embolic material and strengthening the adhesion between the embolic material and the metal carrier.

[0025] Additional aspects and advantages of this application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of this application. Attached Figure Description

[0026] Figure 1 This is a schematic diagram of one side of the front-end device according to an embodiment of this application;

[0027] Figure 2 This is a schematic diagram of the other side of the front-end device in an embodiment of this application;

[0028] Figure 3 for Figure 2 The left view;

[0029] Figure 4 This is a schematic diagram of the front-end device acting on an intravascular embolus according to an embodiment of this application;

[0030] Figure 5 This is a schematic diagram of one side of the front-end device according to another embodiment of this application;

[0031] Figure 6 for Figure 5 A diagram of the other side;

[0032] Figure 7 for Figure 5 The left view.

[0033] Figure label:

[0034] Capillary tube 100, pinhole 101, inner lumen 102;

[0035] Silk thread 200, winding section 201, connecting section 202;

[0036] Guidewire 300, embolization material 400, microcatheter 500, receiving lumen 501, vessel wall 600, push wire 700. Detailed Implementation

[0037] The following will clearly and completely describe the concept and technical effects of this application in conjunction with embodiments, so as to fully understand the purpose, features and effects of this application. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Other embodiments obtained by those skilled in the art based on the embodiments of this application without creative effort are all within the scope of protection of this application.

[0038] In the description of the embodiments of this application, if directional descriptions are involved, such as "up", "down", "front", "back", "left", "right" etc., indicating the directional or positional relationship based on the directional or positional relationship shown in the drawings, it is only for the convenience of describing this application and simplifying the description, and is not intended to indicate or imply that the device or device referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0039] In the description of the embodiments of this application, if a feature is referred to as "setting," "fixing," "connecting," or "installing" on another feature, it can be directly set, fixed, or connected to the other feature, or it can be indirectly set, fixed, connected, or installed on the other feature. In the description of the embodiments of this application, if "several" is involved, it means one or more; if "multiple" is involved, it means two or more; if "greater than," "less than," or "exceeds," it should be understood as excluding the stated number; if "above," "below," or "within," it should be understood as including the stated number. If "first" or "second" is involved, it should be understood as used to distinguish technical features, and not as indicating or implying relative importance or implicitly indicating the number of indicated technical features or the order of the indicated technical features.

[0040] Most current thrombectomy devices are designed with large-diameter, high-radial-force structures, such as tubular mesh structures. In order to successfully remove emboli, a large diameter is usually required. Therefore, during the thrombectomy process, it is very easy to cause abrasion to the blood vessel wall. Stent-type thrombectomy devices exert excessive radial pressure on the blood vessel wall, thereby causing damage to the blood vessel wall and resulting in bleeding. Alternatively, the stent may be over-embedded in the thrombus, causing the thrombus to fragment and produce secondary thrombi that break off and enter smaller downstream blood vessels, causing distal embolism again.

[0041] This application provides a method for obtaining embolic materials, comprising: configuring a metal carrier capable of moving within the lumen of a blood vessel; applying alternating electromagnetic waves or alternating current to the metal carrier, thereby bringing the embolic material into contact with the metal carrier. The alternating electromagnetic waves or alternating current increase the cross-linking density of the embolic material's proteins, thereby enhancing the strength or hardness of the embolic material and strengthening the adhesion between the embolic material and the metal carrier. Using this method to obtain embolic materials, simply bringing the metal carrier into contact with the embolic material, for example, placing it inside the embolic material, avoids radial pressure on the blood vessel compared to methods that involve grasping and collecting the embolic material. This prevents damage to the blood vessel wall. Furthermore, the increased strength or hardness of the embolic material and the enhanced adhesion between the embolic material and the metal carrier effectively reduce the fragmentation of the embolic material, thereby improving thrombectomy efficiency and safety.

[0042] This application provides a thrombectomy device and its front end assembly, which simplifies the structural design of the front end assembly by using a silk thread winding and braiding method. This avoids high radial forces on the blood vessel wall, reduces excessive wear on the blood vessel wall, minimizes fragmentation of the embolus, and prevents distal embolism, thereby achieving efficient and safe embolus removal and clearance. It also reduces the cost of manufacturing the embolus removal device. The embolus referred to in this application refers to abnormal substances that can flow with tissue fluid but are insoluble in it, including but not limited to thrombi and blood clots. The main components of thrombi include insoluble fibrin, platelets, leukocytes, and erythrocytes, with fibrin and platelets being direct causes of thrombosis. The thrombectomy device and its front end assembly of this application are suitable for thrombectomy using the embolus removal method described in the above embodiments, wherein the silk thread in the front end assembly can serve as the aforementioned metal carrier.

[0043] The following is in conjunction with the appendix Figures 1 to 7 The thrombectomy device and front-end apparatus of the embodiments of this application will be described in detail below:

[0044] refer to Figure 1 and Figure 2The first aspect of this application provides a front-end device capable of passing through and moving within the lumen of a blood vessel, thereby facilitating the removal of emboli 400 within the lumen. The front-end device includes a capillary catheter 100, a loop structure, and a guidewire 300. The capillary catheter 100 has a fixing portion, and the loop structure includes multiple threads 200 that are wrapped around the capillary catheter 100 and fixed to the fixing portion. The capillary catheter 100 has a predetermined length and has a proximal end and a distal end along its length. The proximal and distal ends are relative to a control device used to manipulate the movement of the capillary catheter 100. The proximal end is the end of the capillary catheter 100 closer to the control device than the distal end, and typically enters the lumen from the distal end. The filaments 200 extend from the proximal end to the distal end of the capillary 100, and each filament 200 is independent of the others. The filaments 200 are adapted to be acted upon by alternating electromagnetic waves or alternating current, thereby enhancing the strength or hardness of the embolus in contact with the filaments 200, and strengthening the adhesion between the embolus and the filaments 200. The filaments 200 can be made of metallic materials, including but not limited to titanium and its alloys, magnesium and its alloys, aluminum and its alloys, calcium and its alloys, tungsten and its alloys, and shape memory alloys. Multiple filaments 200 can be connected to the positive and negative terminals of an electromagnetic wave generator, thereby acting on the embolus through high-frequency alternating electromagnetic waves or alternating current.

[0045] The filament 200 includes a surrounding section 201 that wraps around the capillary 100. This surrounding section 201 is fixed to the fixing portion, so that during thrombectomy, reference... Figure 4 The loop structure surrounding the capillary 100, through the loop segment 201, acts on the embolus 400, enhancing the cross-linking of fibrin within the embolus 400. This gives the embolus 400 greater strength or hardness, thereby increasing the adhesion between the device and the embolus 400. This makes it easier for the device at the front end to remove the blood embolus 400 completely, ensuring smooth blood flow in the blood vessel and preventing the embolus 400 from breaking off and falling into deeper or smaller blood vessels, causing distal blockage or restenosis.

[0046] A guidewire 300 is positioned at the distal end of the capillary catheter 100 and connected to one of the wires 200 to guide the location of the intravascular embolus 400. The guidewire 300 can be a commonly used guidewire 300 for clinical intravascular interventional therapy, such as a spring guidewire 300 or a shape memory alloy guidewire 300, which has good delivery and guiding properties, enabling it to open the blocked lumen and guide the catheter to the target area. Therefore, positioning the guidewire 300 at the distal end of the capillary catheter 100 effectively guides the capillary catheter 100 to the location of the intravascular embolus 400, thereby retrieval of the embolus using the aforementioned method.

[0047] In addition, when the embolus 400 is removed using the aforementioned front-end device and the aforementioned method, the loop structure can be set to a smaller size, for example, smaller than the diameter of the blood vessel lumen. This effectively avoids wear on the blood vessel wall 600 during movement. Alternatively, based on this structure, the front-end device can be housed in a microcatheter 500 with an external size smaller than the lumen during application. Movement within the blood vessel is performed through the microcatheter 500, and the front-end device is released to remove the embolus 400 when it reaches the location of the embolus. This also effectively prevents wear on the blood vessel wall 600 from the front-end device.

[0048] refer to Figure 1 and Figure 2 In some embodiments of the front-end device, the capillary tube 100 has a hollow interior forming an inner cavity 102. The fixing part includes a plurality of pinholes 101, which are spaced apart from the proximal end to the distal end of the capillary tube 100 on the tube wall and communicate with the inner cavity 102. The thread 200 passes through the pinholes 101, thereby enabling the thread 200 to be fixed on the capillary tube 100, and the fixing structure is simple and easy to implement. Compared with the existing tubular mesh structure front-end device, the structure of the front-end device is simplified, and the manufacturing cost can be effectively reduced. If damage occurs, the thread 200 is also easier to repair and replace.

[0049] refer to Figures 1 to 3 In some embodiments of the front-end device, the multiple pinholes 101 on the capillary 100 include multiple sets of pinhole groups symmetrically arranged on the wall of the capillary 100. For example, there may be two, three, four, or more sets of pinholes. Each set of pinholes is located on different sides of the wall. The pinholes 101 in the same set are used to thread the same thread 200, thereby forming independent threads 200 that do not contact each other. The symmetrical pinhole groups facilitate the threading of the threads 200, thus facilitating the weaving of threads 200 symmetrical on both sides of the capillary 100. Since each set of pinholes is located on different sides of the wall, different sides of the capillary 100 wall can be wrapped with threads 200, thereby enabling the plug 400 to be applied around the wall. (Reference) Figure 4 When in use, the front end device can be inserted into the interior of the embolus 400, and the internal structure of the embolus 400 can be enhanced by high-frequency alternating electromagnetic waves or alternating current acting on the wire 200, thereby improving the adhesion between the embolus and the wire 200 and thus improving the embolus removal efficiency.

[0050] refer to Figure 1 and Figure 2In some embodiments of the front-end device, the spacing between adjacent pinholes 101 along the length of the capillary 100 can be the same or different. The same spacing between pinholes 101 facilitates processing and threading of the wires 200. After threading the wires 200, a uniform loop structure can be formed, avoiding contact between different wires 200.

[0051] Specifically, refer to Figures 1 to 3 Taking a capillary tube 100 comprising two sets of pinholes as an example, the pinholes 101 of the two sets of pinholes are located on different circumferences. The loop structure includes two threads 200, one thread 200 passing through the pinhole 101 of one set of pinholes, and the other thread 200 passing through the pinhole 101 of the other set of pinholes, thereby achieving the spacing between the two threads 200. The two sets of pinholes can be orthogonally distributed on the tube wall, for example, referring to... Figure 3 The axes of the two sets of pinholes 101 are perpendicular to each other, so that after the thread 200 is inserted, the thread 200 surrounds the entire perimeter of the tube wall, thereby enabling it to act on the embolus 400 around the tube wall. Specifically, in some embodiments of the front-end device, each thread 200 is wound to form multiple ring structures. Compared with a straight wrapping structure, the ring structure can have a longer length around the tube wall, thereby improving the thrombectomy efficiency. The multiple ring structures are arranged along the length direction of the capillary 100, further improving the thrombectomy efficiency, helping to shorten the thrombectomy time, and achieving the goal of efficient thrombectomy.

[0052] Each thread 200 also includes a connecting segment 202, which extends along the length of the capillary 100 and is located within the inner cavity 102. One end of the connecting segment 202 is used to connect to the control device, and the other end is connected to the surrounding segment 201. The surrounding segment 201 passes through the needle hole 101 and surrounds the capillary 100, thus fixing the thread 200 to the capillary 100. The connecting segment 202 is housed within the inner cavity of the capillary 100, facilitating coiling. The surrounding segment extends along the length of the capillary 100 and is wound to form at least one loop structure, thereby increasing the length of the thread 200 in contact with the embolus and improving embolectomy efficiency. The diameter of the loop structure ranges from 1 mm to 3 mm; for example, the diameter of the loop structure can be 1 mm, 1.5 mm, 2 mm, 2.5 mm, 3 mm, or any other value between 1 mm and 3 mm. The annular structure of this diameter can avoid radial pressure on the blood vessel wall and provide sufficient effective length for the embolus 400, thereby forming a better effective range and keeping the embolus 400 firmly adhered.

[0053] In some embodiments of the front-end device, the diameter of the filament 200 ranges from 40 μm to 150 μm. For example, the diameter of the filament 200 can be 40 μm, 50 μm, 60 μm, 70 μm, 80 μm, 90 μm, 100 μm, 110 μm, 120 μm, 130 μm, 140 μm, 150 μm, or any other value between 40 μm and 150 μm. This diameter of filament 200 can possess appropriate strength and toughness, thereby maintaining the embolus 400 firmly adhered after application, effectively preventing the embolus 400 from detaching.

[0054] In the front-end device of the above embodiment, the outer surface of the filament 200 is provided with a biocompatible coating. The biocompatible coating is made of a biocompatible material and allows the intravascular embolus 400 to adhere tightly to the loop structure of the metal material, thereby effectively preventing the embolus 400 from falling off. In addition, the outer surface of the filament 200 may also be provided with a contrast-enhancing coating. The contrast-enhancing coating is formed by coating the outer surface of the filament 200 with a contrast-enhancing material, thereby enabling the positioning of the filament 200, i.e., the positioning of the front-end device, in conjunction with blood angiography technology, to assist in the thrombectomy operation and improve the accuracy of advancing to the position of the embolus 400.

[0055] In the front-end device of the above embodiment, the capillary tube 100 is cylindrical, and its inner diameter ranges from 0.25 mm to 0.35 mm. For example, the inner diameter of the capillary tube 100 can be any other value within the range of 0.25 mm, 0.30 mm, 0.35 mm, or 0.25 mm to 0.35 mm. The capillary tube 100 with this inner diameter can effectively bundle the connecting section 202 of the filament 200, and realize the threading and fixing of the filament 200 around the section 201. Furthermore, it is applicable to cases where a pusher wire 700 is threaded inside the capillary tube 100. The pusher wire 700 can effectively reinforce the tube body of the capillary tube 100, thereby enhancing the hardness and toughness of the capillary tube 100. (Refer to the pusher wire 700 for details.) Figure 5 and Figure 6 This allows for better contact with the connecting segment 202 of the filament 200, preventing the connecting segment 202 of the filament 200 from bending or twisting within the capillary catheter 100 due to the filament 200 being too thin, thus facilitating the movement and advancement of the capillary catheter 100 within the microcatheter. The capillary catheter 100 is made of an insulating biocompatible material, thereby insulating it from the filament 200 and allowing for tight adhesion between the intravascular embolization 400 and the capillary catheter 100. The aforementioned material of the capillary catheter 100 can also be configured as an insulating and transparent material, including but not limited to Teflon.

[0056] The front-end device described in this application is applied to the field of ischemic stroke, and through the above-described structural configuration, it can utilize high-frequency alternating electromagnetic waves or alternating current to draw out intravascular emboli 400. The front-end device described in this application can also be used to remove emboli 400 from a patient's blood vessels or other obstructions in endovascular channels, including, but not limited to, the carotid artery, middle cerebral artery, and anterior cerebral artery.

[0057] A second aspect of this application provides a thrombus retrieval device (not shown, but some structures can be referenced). Figures 1 to 4 The device includes a front-end device, a microcatheter 500, and an electromagnetic wave generator (not shown). The front-end device adopts the front-end device of the first aspect embodiment described above. Therefore, it can strengthen the strength or hardness of the embolus 400 by applying alternating electromagnetic waves or alternating current to the wire 200 of the loop structure and by applying the wire 200 to the embolus 400, and strengthen the adhesion of the embolus 400 to the loop structure. This makes the embolus 400 adhere more firmly to the loop structure, thereby allowing it to be removed completely and reducing the breakage of the embolus 400.

[0058] The microcatheter 500 has an internal receiving cavity 501 for accommodating the tip device. Therefore, the inner diameter of the microcatheter 500 is larger than the outer diameter of the capillary 100, and there is a certain space between the inner wall of the microcatheter 500 and the outer wall of the capillary 100 to accommodate the filament 200. The microcatheter 500 can be made of biocompatible materials, thus ensuring appropriate biocompatibility when inserted into blood vessels.

[0059] As described above, the filament 200 has a certain degree of elasticity, allowing it to deform appropriately when the tip device is housed in the receiving cavity 501 of the microcatheter 500. When the tip device is released from the receiving cavity 501, the filament 200 can return to its original shape. Therefore, during operation, the tip device can be housed in the microcatheter 500 and moved within the blood vessel lumen by manipulating the microcatheter 500. It is understood that the external dimensions of the microcatheter 500 should be smaller than the lumen dimensions of the blood vessel; for example, the outer diameter of the microcatheter 500 is smaller than the inner diameter of the blood vessel. This allows the microcatheter 500 to enter and move within the blood vessel lumen. During this process, the tip device does not contact the blood vessel wall 600, thus avoiding radial pressure on the blood vessel wall 600. Upon reaching the embolization point, the tip device is released by pushing it out or retracting the microcatheter 500 to perform thrombectomy, effectively preventing wear on the blood vessel wall 600 caused by the tip device.

[0060] An electromagnetic wave generator is used to apply alternating current (AC) electromagnetic waves or AC electricity to a loop structure. It is understood that the electromagnetic wave generator has a positive and a negative pole. In the front-end device, part of the wires 200 are connected to the positive pole, and another part of the wires 200 are connected to the negative pole, thus enabling the application of high-frequency AC electromagnetic waves or AC electricity to the loop structure formed by these wires 200. As can be seen from the first aspect of the embodiment described above, in some embodiments, the loop structure of the front-end device may include two wires 200, one connected to the positive pole and the other connected to the negative pole. This allows high-frequency AC electromagnetic waves to be applied to the wires 200, greatly simplifying the structure of the front-end device while achieving the bolt removal function, thereby reducing the cost of the bolt remover.

[0061] In some embodiments of the thrombectomy device, a camera device (not shown) is also included, which can be used in conjunction with angiography technology to locate and visualize the front end device with a contrast coating, and to visualize the real-time position of the loop structure, i.e., the real-time position of the front end device, so as to assist the thrombectomy operation and improve the accuracy of advancing the front end device to the embolus 400 position.

[0062] refer to Figures 5 to 7 In some embodiments of the thrombectomy device, a pusher wire 700 is also included. The capillary 100 has a hollow interior forming an inner cavity 102. The pusher wire 700 is housed within the inner cavity 102 and is adapted to connect to a control device. The pusher wire 700 effectively reinforces the capillary 100, thereby increasing its rigidity and toughness, facilitating its movement and pushing within the microcatheter 500. Within the inner cavity 102, the pusher wire 700 contacts the portions of each wire 200 located within the inner cavity 102 of the capillary 100, preventing the wires 200 from bending or twisting within the capillary 100 due to their thinness. One end of the pusher wire 700 is located inside the distal end of the capillary 100 and has a predetermined distance from the circumferential section 201. The other end extends from the distal end of the capillary 100 and is used to connect to the control device, thereby enabling the operation of the pusher wire 700.

[0063] The embolus removal control method according to the third aspect of this application includes:

[0064] Locate the position of the embolus 400 within the lumen;

[0065] The microcatheter 500 containing the front end device is manipulated to enter the lumen and reach the position of the embolus 400. The front end device is released from the microcatheter 500 and the loop structure of the front end device contacts the embolus 400.

[0066] Alternating electromagnetic waves or alternating current are applied to the loop structure of the front-end device to enhance the strength or hardness of the plug 400 and to strengthen the adhesion of the plug 400 to the loop structure.

[0067] The front-end device and the embolus 400 adhering to the front-end device are recovered into the microcatheter 500;

[0068] Manipulate the microcatheter 500 to move it out of the lumen.

[0069] The above-mentioned control method can be achieved by operating and controlling the front end device, microcatheter 500, electromagnetic wave generator and camera device in the thrombectomy device of this application embodiment according to a preset program using commonly used controllers and sensing units in the art. Alternatively, the above-mentioned control method can be achieved by manually cooperating with the operation of the front end device, microcatheter 500, electromagnetic wave generator and camera device in the thrombectomy device. Compared with existing thrombectomy methods, it is more efficient, can remove emboli 400 more completely, and avoids damage to the blood vessel wall 600.

[0070] The embodiments of this application have been described in detail above with reference to the accompanying drawings. However, this application is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of this application. Furthermore, unless otherwise specified, the embodiments and features described in the embodiments of this application can be combined with each other.

Claims

1. A front-end device, characterized in that, The front-end device, capable of passing through the lumen of a blood vessel and moving within it, includes: A capillary tube has a predetermined length, with a proximal end and a distal end at its two ends along the length direction. The interior of the capillary tube is hollow, forming an inner cavity. A fixing part is provided on the wall of the capillary tube, and the fixing part includes a plurality of pinholes. The plurality of pinholes are spaced apart from the proximal end to the distal end on the wall of the capillary tube and communicate with the inner cavity. Among the plurality of pinholes, there are multiple groups of pinholes symmetrically arranged on the wall of the capillary tube. Each group of pinholes is located on a different side of the wall, and the pinholes of two groups of pinholes are located on different circumferences. A loop structure comprising multiple threads extending from the proximal end to the distal end, the threads being able to penetrate into the embolus, the threads being adapted to be acted upon by alternating electromagnetic waves or alternating current, each thread comprising a winding section and a connecting section, the connecting section being located within the inner cavity and extending along the length of the capillary, one end of the connecting section being used to connect to a control device, and the other end being connected to the winding section, the winding section being inserted into the pinhole and surrounding the capillary, the winding section extending along the length of the capillary and being wound to form at least one loop structure, the pinholes in the same pinhole group being used to insert the same thread, forming mutually independent threads; A guidewire, positioned at the distal end and connected to one of the wires, is used to guide the location of an intravascular embolism.

2. The front-end device according to claim 1, characterized in that, The capillary is cylindrical, and its inner diameter ranges from 0.25 mm to 0.35 mm.

3. The front-end device according to claim 1, characterized in that, The diameter of the ring structure ranges from 1 mm to 3 mm.

4. The front-end device according to claim 1, characterized in that, The outer surface of the filament is provided with a biocompatible coating and / or a developing coating, wherein the biocompatible coating is made of a biocompatible material and the developing coating is formed by coating the outer surface of the filament with a developing material.

5. The front-end device according to claim 1, characterized in that, The diameter of the filaments ranges from 40 μm to 150 μm.

6. The front-end device according to any one of claims 1 to 5, characterized in that, The capillary is made of an insulating, biocompatible material.

7. A thrombectomy device, characterized in that, include: The front-end device as described in any one of claims 1 to 6; A microcatheter having an internal receiving cavity, the microcatheter being configured to receive the tip device through the receiving cavity and, upon reaching the location of the embolus, release the tip device from the microcatheter so that the tip device extends into the interior of the embolus; An electromagnetic wave generator is used to apply alternating electromagnetic waves or alternating current to the loop structure.

8. The thrombectomy device according to claim 7, characterized in that, It also includes a camera device for positioning and developing the front-end device with the developing coating.

9. The thrombectomy device according to claim 8, characterized in that, It also includes a pusher wire, the inside of which is hollow to form an inner cavity, the pusher wire is housed in the inner cavity and adapted to be connected to a control device, and the pusher wire is in contact with each of the wires.

10. The thrombectomy device according to claim 9, characterized in that, One end of the push wire is located inside the distal end of the capillary and has a set distance from the circumferential section, while the other end extends from the distal end of the capillary for connecting to the control device.

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