A composite field stimulation device with a magnetic guidance module and an operation method thereof

Abstract

An embodiment of the present invention discloses a composite field stimulation device with a magnetic guidance module and an operation method. The composite field stimulation device with a magnetic guidance module includes: an ultrasonic emission module for emitting an ultrasonic beam to a treatment site of a treatment object; an alternating magnetic field emission module for emitting an electromagnetic wave beam to the treatment site; a liquid magnetic guidance module disposed at the treatment site, the liquid magnetic guidance module including liquid metal and magnetic particles; and a liquid magnetic guidance module enrichment module for guiding the liquid magnetic guidance module to flow to the treatment site. Since the vibration speed of the liquid metal and magnetic particles in the liquid magnetic guidance module in the ultrasonic wave is relatively large, the induced current in the focused magnetoacoustic stimulation electric field generated is also relatively large, enhancing the treatment effect. Moreover, the intensity of the alternating magnetic field can be significantly higher than the intensity of the static magnetic field, further increasing the intensity of the magnetoacoustic coupling electric field.

Description

Technical Field

[0001] The embodiments of the present invention relate to transcranial magnetoacoustic stimulation technology, and in particular to a composite field stimulation device with a magnetic guidance module and an operation method thereof. Background Art

[0002] Neuroelectrical stimulation technology has now been widely used in the treatment of brain nerve diseases. In particular, precise electrical stimulation of deep brain regions is especially needed in the diagnosis and treatment of major brain diseases and other fields. Common non-invasive neuroelectromagnetic stimulations such as transcranial direct current stimulation, transcranial magnetic stimulation technology, etc. at the present stage cannot achieve high spatial resolution at the millimeter level and are difficult to achieve stimulation of deep brain regions. And invasive deep brain electrical stimulation technology requires opening the skull for electrode implantation, with high surgical and application risks and also relatively large operation risks.

[0003] Transcranial magnetoacoustic stimulation is a new type of non-invasive neuroelectrical stimulation technology that can take into account both stimulation focus and stimulation depth. This method is different from the previous form of directly inducing electrical stimulation using changes in electric and magnetic fields, but is based on the magnetoacoustic coupling effect of conductive tissues and uses the high focusing characteristics of ultrasound to achieve non-invasive electrical stimulation with high spatial resolution. This stimulation method can achieve millimeter-level transcranial precise electrical stimulation of the entire brain region including deep brain regions and is a powerful means for treating brain nerve functional diseases.

[0004] However, according to the magnetoacoustic coupling theory, the electric field strength of the magnetoacoustic coupling focused electric field is jointly determined by the vibration velocity of charged particles in the tissue at the focal point and the magnetic induction intensity of the magnetic field. For biological tissues, the electric field strength of the magnetoacoustic coupling in the existing transcranial magnetoacoustic technology is very low, far from reaching the nerve action potential threshold, so the treatment effect is not ideal. Summary of the Invention

[0005] The present invention provides a composite field stimulation device with a magnetic guidance module and an operation method thereof to increase the electrical stimulation intensity of the part to be treated and improve the treatment effect.

[0006] In a first aspect, the embodiments of the present invention provide a composite field stimulation device with a magnetic guidance module, including:

[0007] An ultrasonic wave emission module for emitting an ultrasonic wave beam to the part to be treated of the object to be treated;

[0008] An alternating magnetic field emission module for emitting an electromagnetic wave beam to the part to be treated;

[0009] A liquid magnetic guidance module, the liquid magnetic guidance module is placed at the part to be treated, and the liquid magnetic guidance module includes liquid metal and magnetic particles;

[0010] A liquid magnetic guidance module enrichment module for guiding the flow of the liquid magnetic guidance module to the treatment site to be treated;

[0011] Wherein, the included angle between the ultrasonic beam and the electromagnetic wave beam at the treatment site to be treated is greater than 0 degrees.

[0012] Optionally, the liquid metal includes gallium or gallium-based liquid metal.

[0013] Optionally, the magnetic particles include magnetic Fe3O4 nanoparticles.

[0014] Optionally, the included angle between the ultrasonic beam and the electromagnetic wave beam at the treatment site to be treated is 90 degrees.

[0015] Optionally, the liquid magnetic guidance module enrichment module includes a static magnet and a guiding bracket, the static magnet is fixed on the guiding bracket, and the guiding bracket is used to adjust the position and orientation of the static magnet.

[0016] Optionally, the ultrasonic emission module includes a focused ultrasound transducer and a pulsed ultrasound excitation source, and the pulsed ultrasound excitation source is used to provide excitation to the focused ultrasound transducer.

[0017] Optionally, the ultrasonic emission module further includes a control unit, and the control unit adjusts the focal position of the focused ultrasound transducer by adjusting the output parameters of the pulsed ultrasound excitation source.

[0018] Optionally, the ultrasonic emission module further includes a transducer bracket, the focused ultrasound transducer is fixed on the transducer bracket, and the transducer bracket is used to adjust the position and orientation of the focused ultrasound transducer.

[0019] Optionally, the transducer bracket includes a bracket body, a first slide rail and a second slide rail, the first slide rail is installed on the installation surface along a first direction, the second slide rail is installed on the first slide rail along a second direction, the second slide rail can slide on the first slide rail, and the bracket body can slide on the second slide rail;

[0020] Wherein, the included angle between the first direction and the second direction is greater than 0 degrees.

[0021] In a second aspect, an operating method of a composite field stimulation device with a magnetic guidance module provided by an embodiment of the present invention is run on any of the above composite field stimulation devices with a magnetic guidance module, and includes:

[0022] Inject the liquid magnetic guidance module into the area where the treatment site to be treated is located;

[0023] Control the liquid magnetic guidance module enrichment module to attach the magnet to the injection site of the liquid magnetic guidance module;

[0024] By controlling the liquid magnetic guidance module enrichment module, make the magnet move along the object to be treated, so as to guide the liquid magnetic guidance module in the object to be treated to flow and enrich to the treatment site;

[0025] Control the alternating magnetic field emission module to emit the electromagnetic wave beam to the treatment site;

[0026] Control the ultrasonic emission module to emit the ultrasonic beam to the treatment site.

[0027] In the embodiment of the present invention, the composite field stimulation device with a magnetic guidance module emits an ultrasonic beam to the treatment site of the object to be treated through the ultrasonic emission module; emits an electromagnetic wave beam to the treatment site through the alternating magnetic field emission module; the liquid magnetic guidance module is placed at the treatment site, and the liquid magnetic guidance module includes liquid metal and magnetic particles; the liquid magnetic guidance module is guided to flow to the treatment site through the liquid magnetic guidance module enrichment module; wherein, the included angle between the ultrasonic beam and the electromagnetic wave beam at the treatment site is greater than 0 degrees. Since the vibration speed of the liquid metal and magnetic particles in the liquid magnetic guidance module in the ultrasonic wave is much greater than the vibration speed of the charged particles in the biological tissue, these vibrating conductive particles are affected by the Lorentz force in the alternating magnetic field, and a local induced current is formed in the ultrasonic focusing area, and the focused magnetoacoustic stimulation electric field generated is much greater than the induced current generated by the vibration of the charged particles in the biological tissue. Therefore, the intensity of the magnetoacoustic coupling focused electric field is greatly improved, and the treatment effect is enhanced. By controlling the position, intensity and attitude of the ultrasonic beam and the electromagnetic wave beam, a composite field can be accurately formed at the treatment site. And the intensity of the alternating magnetic field can be significantly higher than the intensity of the static magnetic field, so that the intensity of the magnetoacoustic coupling electric field is further improved. Description of the Drawings

[0028] Figure 1 It is a schematic structural diagram of a composite field stimulation device with a magnetic guidance module provided by an embodiment of the present invention;

[0029] Figure 2 It is a working principle diagram of a composite field stimulation device with a magnetic guidance module provided by an embodiment of the present invention;

[0030] Figure 3 It is a flowchart of an operation method of a composite field stimulation device with a magnetic guidance module provided by an embodiment of the present invention. Detailed Embodiments

[0031] The present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It can be understood that the specific embodiments described herein are only used to explain the present invention, rather than limiting the present invention. In addition, it should be noted that for the convenience of description, only the parts related to the present invention are shown in the drawings, rather than all the structures.

[0032] Transcranial magnetoacoustic coupling stimulation is a non-invasive electrical stimulation technique based on the magnetoacoustic coupling effect of conductive tissues, which uses the high focusing characteristics of ultrasound to achieve high spatial resolution. Its basic principle is as follows: Conductive particles in tissues are excited by ultrasound to vibrate. In the presence of a magnetic field (which can be an alternating magnetic field) perpendicular to the direction of particle vibration, the conductive particles are subjected to the Lorentz force, and positive and negative particles deflect and converge towards both ends of the tissue along the direction of the vector product of the magnetic field and the ultrasound field, forming an internal induced electric field. It can be seen that for a conductive biological tissue placed in a magnetic field, if an ultrasonic signal is incident in one direction, based on the magnetoacoustic coupling effect, an internal coupled electric field and coupled current of the same frequency will be generated in the tissue in a direction perpendicular to both the magnetic field and the sound field directions. The induced electric field strength follows E = v j ×B, and the magnitudes of the induced electric field E and the coupled electric field are linearly related to the particle vibration velocity v j and the magnetic induction intensity B of the magnetic field. The direction of the induced electric field is the direction of the vector product of the ultrasonic sound field and the magnetic field.

[0033] In an ideal pure medium, based on acoustic theory, the vibration velocity of particles in ultrasound is v = Pρc m , where P is the ultrasonic sound pressure, ρ is the medium density, and c m is the sound velocity in the medium; however, in non-ideal biological tissues, the actual vibration velocity v of charged particles j is much smaller than the vibration velocity of the medium. Therefore, the induced electric field strength in biological tissues is also small, and the therapeutic effect of magnetoacoustic coupling electrical stimulation is poor.

[0034] Figure 1 The following is a schematic structural diagram of a composite field stimulation device with a magnetic guidance module provided by an embodiment of the present invention. Refer to Figure 1 . Based on the above problems, an embodiment of the present invention provides a composite field stimulation device with a magnetic guidance module, including:

[0035] An ultrasonic wave emission module 1, configured to emit an ultrasonic wave beam to a treatment site of a treatment object;

[0036] An alternating magnetic field emission module 2, configured to emit an electromagnetic wave beam to the treatment site;

[0037] A liquid magnetic guidance module (not shown in the figure), the liquid magnetic guidance module is placed at the treatment site, and the liquid magnetic guidance module includes liquid metal and magnetic particles;

[0038] The liquid magnetic guidance module enrichment module 3 is used to guide the liquid magnetic guidance module to flow to the treatment site;

[0039] Wherein, the included angle between the ultrasonic beam and the electromagnetic wave beam at the treatment site is greater than 0 degrees.

[0040] Among them, the ultrasonic wave emission module 1 can be any device capable of emitting ultrasonic waves to the treatment site. The embodiments of the present invention do not limit the specific type of the ultrasonic wave emission module 1, and specific examples of the ultrasonic wave emission module 1 will be described below. The alternating magnetic field emission module 2 can emit electromagnetic waves to the treatment site. Since the electromagnetic wave includes an alternating electric field and an alternating magnetic field, an alternating magnetic field can be constructed at the treatment site by emitting electromagnetic waves through the alternating magnetic field emission module 2. The alternating magnetic field emission module 2 can be any device capable of constructing an alternating magnetic field at the treatment site. The embodiments of the present invention do not limit the specific structure of the alternating magnetic field emission module 2, as long as the above requirements are met. The treatment site is the tissue of a human or animal body that needs magnetoacoustic coupled electric field stimulation treatment. This tissue can be brain tissue, or any muscle or nerve tissue, and is also the intersection of the ultrasonic beam and the electromagnetic wave. The treatment site can be changed by changing the postures of the ultrasonic wave emission module 1 and the alternating magnetic field emission module 2. The alternating magnetic field and the ultrasonic wave generate magnetoacoustic coupling to form an electric field at the treatment site in the brain. The electric field strength and direction are the vector product of the ultrasonic wave and the alternating magnetic field. Therefore, it is necessary to ensure that the included angle between the ultrasonic beam and the electromagnetic wave beam at the treatment site is greater than 0 degrees. Preferably, the included angle between the ultrasonic beam and the electromagnetic wave beam at the treatment site is 90 degrees. In this way, the maximum electric field strength can be obtained, the current magnitude at the treatment site can be increased, and a better treatment effect can be obtained. The liquid magnetic guidance module enrichment module 3 is used to inject the liquid magnetic guidance module near the treatment site, and then guide the magnetic particles doped in the liquid metal to flow through the magnetic field. The magnetic particles drive the liquid metal, so that the liquid magnetic guidance module is enriched at the treatment site to position the liquid magnetic guidance module. The embodiments of the present invention do not limit the specific structure of the liquid magnetic guidance module enrichment module 3, as long as the above requirements are met, and a liquid magnetic guidance module enrichment module 3 will be given below. As mentioned above, in non-ideal biological tissues, the vibration speed of actual charged particles is much smaller than that of an ideal pure medium. Since metal can be regarded as an ideal pure medium and the conductive particles are only electrons, the magnetoacoustic coupled electric field in metal is much greater than that in biological tissues. By enriching liquid metal at the treatment site, the biological tissue medium can be replaced with a liquid metal medium, thereby increasing the vibration speed of charged particles and greatly enhancing the magnetoacoustic coupled focusing electric field strength and the treatment effect.

[0041] In some other embodiments, the liquid metal includes gallium or gallium-based liquid metal.

[0042] Among them, elemental gallium and gallium alloy materials such as gallium-indium, gallium-indium-tin, and gallium-indium-tin-zinc have excellent physical and chemical properties. For example, they have a low melting point (below 300 °C), a high boiling point (above 1000 °C), low viscosity, high surface tension, high thermal conductivity, a wide range of metal dissolution capabilities, multiple responsiveness, and a natural two-dimensional nano-oxide film on the surface. They can also reduce the thermal effect and cavitation effect of ultrasound in transcranial magnetoacoustic coupling stimulation technology. Moreover, elemental gallium and gallium alloys are non-toxic, and the liquid metal is a gallium alloy material. Its physical and chemical properties are very stable, with good biocompatibility, and it will not volatilize easily in the air like mercury, so it will not directly cause harm to people. Relevant research shows that only when the ingestion concentration of gallium is higher than 750 mg / kg will it show toxicity to the human kidney. Therefore, choosing gallium or gallium-based liquid metal as an enhancer for magnetoacoustic coupling stimulation has high safety.

[0043] In some other embodiments, the magnetic particles include magnetic Fe3O4 nanoparticles.

[0044] Among them, Fe3O4 is non-toxic to the human body and animals, and has a relatively low price. The size of the magnetic Fe3O4 nanoparticles does not exceed 100 nanometers, which is an ideal material for guiding the flow and enrichment of liquid metal.

[0045] In some other embodiments, the liquid magnetic guidance module enrichment module includes a static magnet 31 and a guiding bracket 32. The static magnet is fixed on the guiding bracket, and the guiding bracket is used to adjust the position and orientation of the static magnet.

[0046] Among them, the static magnet 31 can be located at the end of the guiding bracket 32. During use, by adjusting the guiding bracket 32, the spatial position movement and magnetic field direction adjustment of the static magnetic field provided by the liquid magnetic guidance module enrichment module 3 can be realized. Thereby guiding the flow of the liquid magnetic guidance module to complete the positioning of the liquid magnetic guidance module. The embodiments of the present invention do not limit the structure of the guiding bracket 32, and any structure that can meet the above requirements can be used as the guiding bracket 32.

[0047] In some other embodiments, the alternating magnetic field emission module 2 includes an alternating coil 21 and an alternating magnetic field exciter 23. The alternating magnetic field exciter 23 is used to output an alternating current to the alternating coil 21.

[0048] Among them, the output end of the alternating magnetic field exciter 23 is connected to the input end of the alternating coil 21. The alternating coil 21 can be of a circular structure or an 8-shaped structure, and it can be made of copper wire wound. Among them, the 8-shaped alternating coil 21 has better magnetic field focusing performance. The alternating magnetic field exciter 23 can include a charging circuit, an energy storage capacitor, a pulse shaping circuit, a thyristor switch, etc. The alternating magnetic field exciter 23 charges the energy storage capacitor after rectifying the high-voltage power supply, obtains an alternating current through the charging and discharging of the capacitor, and shapes and outputs the alternating current through the pulse shaping circuit. The alternating magnetic field exciter 23 can generate an alternating current with a certain repetition frequency and a certain pulse width, such as an alternating current with a repetition frequency of 1 Hz and a pulse width of 280 μs. The excited alternating coil 21 receives the above alternating current, and based on the electromagnetic induction theory, the alternating coil 21 can generate a corresponding alternating magnetic field. For example, an alternating magnetic field with a repetition frequency of 1 Hz and a pulse width of 280 μs.

[0049] In some other embodiments, the ultrasonic emission module 1 includes a focused ultrasound transducer 11 and a pulsed ultrasound excitation source 12, and the pulsed ultrasound excitation source 12 is used to provide excitation to the focused ultrasound transducer 11.

[0050] Among them, the focused ultrasound transducer 11 can be a single-element focused ultrasound transducer or a phased array focused ultrasound transducer. Its main frequency can be 0.3 MHz - 5 MHz, and the frequency can be selected based on the stimulation depth of the object to be stimulated. The number of excitation channels of the pulsed ultrasound excitation source 12 is the same as the number of elements of the focused ultrasound transducer 11 to ensure that each channel can independently excite each element.

[0051] In some other embodiments, the ultrasonic emission module 1 further includes a control unit 13, and the control unit 13 adjusts the focal position of the focused ultrasound transducer 11 by adjusting the output parameters of the pulsed ultrasound excitation source 12.

[0052] Among them, when the focused ultrasound transducer 11 includes a phased array focused ultrasound transducer, the focused ultrasound transducer 11 further includes a control unit 13. The control unit 13 can be a microcomputer or an industrial control computer, and the excitation parameters of each excitation channel of the pulsed ultrasound excitation source 12 are controlled by the microcomputer or the industrial control computer. The excitation parameters can include excitation voltage, excitation pulse width, excitation frequency, etc. By adjusting the pulsed excitation parameters of each excitation channel by the microcomputer or the industrial control computer, a focused ultrasound pulse signal with adjustable focal length and focal position can be emitted by the transducer. The pulsed ultrasound excitation source 12 and the microcomputer can be a Verasonics ultrasound development platform.

[0053] In some other embodiments, the ultrasonic emission module 1 further includes a transducer support 14, and the focused ultrasonic transducer 11 is fixed on the transducer support 14. The transducer support 14 is used to adjust the position and orientation of the focused ultrasonic transducer 11. The alternating magnetic field emission module 2 includes an alternating coil 21 and a coil fixing bracket 22. The coil fixing bracket 22 is used to adjust the spatial position and orientation of the alternating coil 21.

[0054] Among them, the transducer support 14 can be any structure capable of adjusting the position and orientation of the focused ultrasonic transducer 11. The embodiments of the present invention do not limit the specific structure of the transducer support 14. The coil fixing bracket 22 can be any structure capable of adjusting the position and orientation of the alternating coil 21. The embodiments of the present invention do not limit the specific structure of the coil fixing bracket 22. By adjusting the coil fixing bracket 22 and the transducer support 14, the postures of the alternating coil 21 and the focused ultrasonic transducer 11 are changed, so that the alternating magnetic field constructed by the alternating coil 21 and the ultrasonic wave emitted by the focused ultrasonic transducer 11 intersect at any desired position. The alternating magnetic field and the ultrasonic wave can be at a desired angle, and the preferred angle is 90 degrees.

[0055] Figure 2 This is the working principle diagram of a composite field stimulation device with a magnetic guidance module provided by the embodiments of the present invention. Refer to Figure 2 At this time, a magnetoacoustic coupling electric field E in the same direction as the z-axis in the three-dimensional rectangular coordinate system can be generated in the direction of the vector product of the ultrasonic wave V in the same direction as the x-axis in the three-dimensional rectangular coordinate system and the alternating magnetic field B in the same direction as the y-axis in the three-dimensional rectangular coordinate system. MA At the same time, the alternating coil 21 will also generate a magnetoinductive electric field E in the same direction as the z-axis in the three-dimensional rectangular coordinate system at the treatment site in the brain. M E M has the same direction as E MA , and the intensities are superimposed to form a composite physical field E in the same direction in the target area M +E MA . Further enhancing the intensity of the stimulating electric field; plus the original orthogonal direction, that is, the focused ultrasonic field V in the same direction as the x-axis in the three-dimensional rectangular coordinate system, a magnetoacoustic coupling electric field E can be generated at the treatment site in the brain MA , the magnetoinductive electric field E M and the focused ultrasonic field V. The above three physical fields together constitute a composite field to stimulate the brain.

[0056] In some other embodiments, the transducer support 14 includes a support body 141, a first slide rail 142, and a second slide rail 143. The first slide rail 142 is mounted on the mounting surface along a first direction, the second slide rail 143 is mounted on the first slide rail 142 along a second direction, the second slide rail 143 can slide on the first slide rail 142, and the support body 141 can slide on the second slide rail 143;

[0057] Wherein, the included angle formed by the first direction and the second direction is greater than 0 degrees.

[0058] Wherein, the included angle formed by the first direction and the second direction can be 90 degrees, and the support body 141 can expand and contract in a direction perpendicular to the first direction and the second direction. One end of the support body 141 is connected with a focused ultrasound transducer 11 through a direction selector, and the focused ultrasound transducer 11 can change its orientation relative to the support body 141. Through the cooperation of the support body 141, the first slide rail 142, and the second slide rail 143, the spatial position of the focused ultrasound transducer 11 can be changed.

[0059] In some other embodiments, it may further include a treatment object fixing device 4 for fixing the treatment object.

[0060] Wherein, the treatment object fixing device 4 may only include a head fixing device; may only include a torso fixing device; may also include a head fixing device and a torso fixing device at the same time. The head fixing device can be connected to the torso fixing device. The torso fixing device can be a primate fixing table or a seat. Wherein, the included angle formed by the first direction and the second direction is greater than 0 degrees.

[0061] Figure 3 It is a flowchart of an operation method of a composite field stimulation device with a magnetic guidance module provided by an embodiment of the present invention. Refer to Figure 3 . An embodiment of the present invention also provides an operation method of a composite field stimulation device with a magnetic guidance module, which runs on any one of the composite field stimulation devices with a magnetic guidance module in the above embodiments, including:

[0062] S1: Inject the liquid magnetic guidance module into the area where the treatment site is located.

[0063] Wherein, one or several of gallium-based liquid metals such as gallium, gallium indium, gallium indium tin, and gallium indium tin zinc can be used as the liquid metal part in the liquid magnetic guidance module. Magnetic nanoparticles, such as magnetic Fe3O4 nanoparticles, are mixed into the liquid metal to form a magnetic liquid metal, and the magnetic liquid metal is used as an enhancer and injected into the treatment site of the treatment object. For example, when treating the head, it can be injected near the affected area of the treatment object's head.

[0064] S2: Control the liquid magnetic guidance module enrichment module to attach a magnet to the injection site of the liquid magnetic guidance module.

[0065] S3: By controlling the liquid magnetic guidance module enrichment module, move the magnet along the object to be treated, so as to guide the flow and enrichment of the liquid magnetic guidance module in the object to be treated to the part to be treated.

[0066] Among them, adjust the liquid magnetic guidance module enrichment module 3, closely attach the static magnet for magnetic guidance in the liquid magnetic guidance module enrichment module 3 to the head of the object to be treated, and continue to adjust the liquid magnetic guidance module enrichment module 3. Use the static magnet in the liquid magnetic guidance module enrichment module 3 to guide the flow and enrichment of the magnetic liquid metal in the body to the part to be treated, that is, position the liquid magnetic guidance module at the part to be treated.

[0067] S4: Control the alternating magnetic field emission module to emit electromagnetic wave beams to the part to be treated.

[0068] S5: Control the ultrasonic emission module to emit ultrasonic beams to the part to be treated.

[0069] Among them, if the alternating magnetic field emission module 2 includes a coil fixing bracket 22, an alternating coil 21 and an alternating coil excitation device 23. The position and orientation of the alternating coil 21 can be adjusted by adjusting the coil fixing bracket 22. And turn on the switch of the alternating coil excitation device 23, and the alternating coil excitation device 23 excites the alternating coil 21 to emit electromagnetic waves, so that the alternating magnetic field is at the part to be treated of the object to be treated. For example, the part to be treated can be the head of the object to be treated. Adjust the position of the focused ultrasound transducer 11 so that the focused ultrasound transducer 11 can contact the scalp part mapped by the brain area of the object to be treated through the coupling agent and is orthogonal to the direction of the electromagnetic wave beam at this time. Then, adjust the output parameters of the single-channel or multi-channel pulsed ultrasound excitation source 12 in the ultrasonic emission module 1, so that the focal length and focus of the ultrasonic transducer in the ultrasonic emission module 1 are aligned with the part to be treated in the brain of the object to be treated. At this time, turn on the output of the pulsed ultrasound excitation source 12, and accurate transcranial magnetoacoustic stimulation can be performed on the part to be treated in the brain of the object to be treated. Due to the enhancement of the magnetic liquid metal at the part to be treated, the magnetoacoustic coupling efficiency is greatly improved, and the intensity of the magnetoacoustic coupling electric field is greatly improved. During the stimulation, different sound pressures can be achieved by adjusting the magnitude of the ultrasonic excitation, so as to obtain the required different stimulation intensities; different magnetoacoustic stimulation directions can be achieved by adjusting the relative position of the focused sound field and the alternating magnetic field. Realize flexible adjustment of the direction to be stimulated at the part to be treated.

[0070] Note that the above is only a preferred embodiment of the present invention and the technical principles applied. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein. Various obvious changes, re-adjustments, combinations with each other, and substitutions can be made by those skilled in the art without departing from the protection scope of the present invention. Therefore, although the present invention has been described in more detail through the above embodiments, the present invention is not limited to the above embodiments only. Without departing from the concept of the present invention, it may also include more other equivalent embodiments, and the scope of the present invention is determined by the scope of the appended claims.

Claims

1. A composite field stimulation device with a magnetic guidance module, characterized in that, Comprising: An ultrasonic emission module, configured to emit an ultrasonic beam towards a treatment site of a subject to be treated; An alternating magnetic field emission module, configured to emit an electromagnetic wave beam towards the treatment site; A liquid magnetic guidance module, which is placed at the treatment site and includes liquid metal and magnetic particles; A liquid magnetic guidance module enrichment module, configured to guide the liquid magnetic guidance module to flow to the treatment site; Wherein, the included angle formed by the ultrasonic beam and the electromagnetic wave beam at the treatment site is greater than 0 degrees.

2. The composite field stimulation device with a magnetic guidance module according to claim 1, characterized in that The liquid metal includes gallium or gallium-based liquid metal.

3. The composite field stimulation device with a magnetic guidance module according to claim 1, characterized in that The magnetic particles include magnetic Fe3O4 nanoparticles.

4. The composite field stimulation device with a magnetic guidance module according to claim 1, characterized in that The included angle formed by the ultrasonic beam and the electromagnetic wave beam at the treatment site is 90 degrees.

5. The composite field stimulation device with a magnetic guidance module according to claim 1, characterized in that, The liquid magnetic guidance module enrichment module includes a static magnet and a guiding bracket. The static magnet is fixed on the guiding bracket, and the guiding bracket is used to adjust the position and orientation of the static magnet.

6. The composite field stimulation device with a magnetic guidance module according to claim 1, wherein The ultrasonic emission module includes a focused ultrasound transducer and a pulsed ultrasound excitation source, and the pulsed ultrasound excitation source is configured to provide excitation to the focused ultrasound transducer.

7. The composite field stimulation device with a magnetic guidance module according to claim 6, wherein The ultrasonic emission module further includes a control unit, and the control unit adjusts the focal position of the focused ultrasound transducer by adjusting the output parameters of the pulsed ultrasound excitation source.

8. The composite field stimulation device with a magnetic guidance module according to claim 6, wherein, The ultrasonic emission module further includes a transducer bracket, and the focused ultrasound transducer is fixed on the transducer bracket, and the transducer bracket is used to adjust the position and orientation of the focused ultrasound transducer.

9. The composite field stimulation device with a magnetic guidance module according to claim 8, characterized in that, The transducer bracket includes a bracket body, a first slide rail and a second slide rail. The first slide rail is installed on the installation surface along a first direction, the second slide rail is installed on the first slide rail along a second direction, the second slide rail can slide on the first slide rail, and the bracket body can slide on the second slide rail; Wherein, the included angle formed by the first direction and the second direction is greater than 0 degrees.

10. A method for operating a composite field stimulation device with a magnetic guidance module, which operates on the composite field stimulation device with a magnetic guidance module according to any one of claims 1-9, characterized in that, Comprising: Injecting the liquid magnetic guidance module into the area where the treatment site is located; Controlling the liquid magnetic guidance module enrichment module to attach the magnet to the injection site of the liquid magnetic guidance module; By controlling the liquid magnetic guidance module enrichment module, moving the magnet along the subject to be treated to guide the liquid magnetic guidance module in the body of the subject to flow and enrich to the treatment site; Controlling the alternating magnetic field emission module to emit the electromagnetic wave beam towards the treatment site; Controlling the ultrasonic emission module to emit the ultrasonic beam towards the treatment site.

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