POGLUT3 as a biomarker for gastrointestinal diseases and uses thereof

By detecting mutations in the POGLUT3 gene or protein, diagnostic kits and drugs have been developed, solving the challenges of early diagnosis and treatment of gastrointestinal diseases, reducing disease risks and toxic side effects, and providing new therapeutic targets and directions.

CN115704050BActive Publication Date: 2026-02-27GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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Patent Information

Application Number
CN202110931648.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2021-08-13
Publication Date
2026-02-27
Estimated Expiration
2041-08-13

AI Technical Summary

Technical Problem

In the current technology, the causes of gastrointestinal diseases such as inflammatory bowel disease (IBD), allergic gastrointestinal diseases and colorectal cancer are unclear, and there is a lack of effective early diagnosis and treatment methods. Existing drug treatments have toxic side effects and risks.

Method used

Diagnostic kits and drugs can be developed by using reagents that detect the POGLUT3 gene or POGLUT3 protein and utilizing its mutated forms as biomarkers to reduce the expression of the POGLUT3 gene or protein in order to prevent and treat gastrointestinal diseases.

Benefits of technology

It provides new methods for early screening and treatment of gastrointestinal diseases, reducing disease risk and toxic side effects, and improving diagnostic accuracy and treatment effectiveness.

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Abstract

The present application relates to the technical field of biotechnology, and in particular, provides a POGLUT3 as a gastrointestinal disease biomarker and application thereof. The present application provides a POGLUT3 gene or a POGLUT3 gene with 955C>T and / or 848T>G mutations, and application thereof in a biomarker for preventing, diagnosing or treating gastrointestinal diseases. The technical scheme of the present application provides a new theoretical basis for the pathogenesis of gastrointestinal diseases, and also provides a new direction and therapeutic target for the treatment of gastrointestinal diseases.
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Citation Information

Patent Citations

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