Medical adhesive, delivery device and delivery system

Abstract

The present invention discloses a medical adhesive, a delivery device and a delivery system. The delivery device includes a marking catheter and a glue injection tube, and the marking catheter is connected to the glue injection tube; the delivery system includes the aforementioned delivery device, the first joint of the glue injection tube at the end of the glue injection tube is connected to a glue injector, and the glue injector includes a glue injection cavity, a snap ring, a glue injection piston, a piston latch and a glue outlet hole; the glue injector is connected to the glue gun connection groove at the end of the glue gun through the glue injector cylinder seat at its end, and the other end of the glue injection piston is connected to the driven rack inside the glue gun. The present invention uses a spring as the elastic part of the glue gun, which has the characteristics of fatigue resistance and increases the service life; it can achieve quantitative extrusion and repeated use; the marking catheter has a first mark and a second mark, so that the length of the catheter penetrating into the human tissue can be known; the structure is simple and the assembly difficulty is low; through the snap ring design of the glue injector, the glue injection components are reduced and the effect of equal glue extrusion is achieved.

Description

Technical Field

[0001] The present invention relates to a medical adhesive and a delivery device, and in particular to a medical adhesive, a delivery device and a delivery system. Background Art

[0002] Endovenous closure of varicose veins in the lower extremities differs from existing traditional open stripping and thermal ablation treatments. Radiofrequency partial resection and laser partial resection require deep anesthesia and have side effects of burns and nerve damage. Both of these methods require wearing compression stockings for 2-4 weeks. This applies not only to endovenous closure of varicose veins in the lower extremities, but also to closure of capillaries, vascular and non-vascular fistulas, and fallopian tubes. This system utilizes an innovative, special medical adhesive in a minimally invasive manner to precisely close severely affected areas in the lower extremities of patients with varicose veins, resulting in minimal surgical trauma and significantly shortened operative time.

[0003] The glue gun used during surgery uses a single trigger pull to control the quantitative extrusion of medical adhesive from the glue injector, achieving phased venous closure. Currently, the handle and transmission mechanism of glue guns are made of plastic, which is not fatigue-resistant and reduces service life. Prior art solutions use manual liquid dispensers as adhesive introduction devices. While these can controllably and precisely dispense adhesive into vessels, they lack quantitative extrusion and are difficult to reuse. Existing structures are complex and difficult to assemble. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to overcome the defects of the prior art and provide a medical adhesive, a delivery device and a delivery system.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0006] The present invention provides a conveying device, comprising a marking catheter and a glue injection tube, wherein:

[0007] The marking conduit is connected to the glue injection tube;

[0008] The outer surface of the marking catheter is provided with a first mark and a second mark, wherein,

[0009] The second marks are distributed between the first marks;

[0010] The end of the glue injection pipe is installed with a first glue injection pipe joint and a second glue injection pipe joint, wherein,

[0011] The glue injection tube is connected to the marking catheter through the second glue injection tube joint.

[0012] As a preferred technical solution of the present invention, a glue injection pipe fitting is installed at one end of the glue injection pipe, wherein:

[0013] The glue injection pipe is provided with a developing device;

[0014] The second joint of the glue injection tube is connected to the marking catheter joint at the end of the marking catheter, wherein,

[0015] A marking catheter handle is installed on the marking catheter at one side of the marking catheter connector;

[0016] A glue injection tube handle is provided between the first glue injection tube joint and the second glue injection tube joint.

[0017] The present invention provides a medical adhesive delivery system, comprising the aforementioned delivery device, wherein the first joint of the injection tube at the end of the injection tube is connected to a glue injector, wherein:

[0018] The glue injector comprises a glue injection cavity, a buckle ring, a glue injection piston, piston locking teeth and a glue injection hole;

[0019] The glue injector is provided with a glue injection cavity, wherein:

[0020] A glue injection piston is installed in the glue injection cavity;

[0021] A buckle ring is installed at the end of the glue injector, and a piston locking tooth is provided on the glue injection piston;

[0022] A glue injection hole is provided at the end of the glue injection cavity.

[0023] As a preferred technical solution of the present invention, the buckle ring is clamped into the end flange of the glue injector, wherein,

[0024] A snap ring limiting block is provided at one end of the snap ring, and the snap ring limiting block is installed in a groove of the end flange of the glue injector;

[0025] The other end of the buckle ring is provided with a buckle ring tooth, wherein,

[0026] A buckle ring locking block is provided on the inner side of the buckle ring close to the glue injector flange.

[0027] As a preferred technical solution of the present invention, a second locking block of the buckle ring is provided on the outer side of the buckle ring, wherein:

[0028] A bending point of the buckle ring is provided on one side of the second locking block of the buckle ring;

[0029] A buckle ring locking groove is provided on the buckle ring on the same side as the buckle ring second locking block.

[0030] The present invention provides a medical adhesive delivery system, comprising the aforementioned delivery device, wherein the first joint of the injection tube at the end of the injection tube is connected to a connecting tube end assembly of a press-type injection device, wherein:

[0031] The press-type glue injector includes a housing;

[0032] A storage cavity is provided in the housing, wherein

[0033] A pressure ring is installed on the top of the shell;

[0034] The pressure ring is provided with a liquid outlet pipe, wherein:

[0035] A first one-way valve and a second one-way valve are installed in the liquid outlet pipe;

[0036] A spring is provided between the first one-way valve and the second one-way valve;

[0037] The end of the pressure ring is equipped with a connecting pipe, wherein

[0038] The connecting pipe is connected to the liquid outlet pipe;

[0039] The end portion of the connecting pipe is installed with the connecting pipe end portion assembly.

[0040] The present invention provides a medical adhesive delivery system, comprising the aforementioned delivery device, wherein the glue injector is connected to the glue gun connection groove at the end of the glue gun through the glue injector cylinder seat at the end thereof, wherein:

[0041] The other end of the glue injection piston is connected to the driven rack inside the glue gun;

[0042] The driven rack is meshed with the active rack.

[0043] As a preferred technical solution of the present invention, the active rack is mounted on the top of the trigger via a shaft pin;

[0044] A cavity is provided in the handle of the glue gun and a limit plate is fixed at the bottom of the cavity, wherein:

[0045] A rebound spring is provided between the trigger and the limiting plate;

[0046] A trigger limiting column is provided on one side of the trigger, wherein,

[0047] The trigger limiting column is arranged on the inner wall of the cavity of the glue gun handle;

[0048] The end of the active rack is equipped with an axle pin, and the end of the axle pin is equipped with a tooth filling switch, wherein:

[0049] The tooth filling switch is located on the outer side of the glue gun.

[0050] As a preferred technical solution of the present invention, the active rack is mounted on the top of the trigger via a shaft pin;

[0051] A cavity is provided in the handle of the glue gun and a limit plate is fixed at the bottom of the cavity, wherein:

[0052] A raised column is installed on one side of the limiting plate;

[0053] The protruding column is sleeved with a second rebound spring, wherein:

[0054] A hole groove corresponding to the raised column is provided on a side of the trigger opposite to the raised column;

[0055] The end of the active rack is equipped with an axle pin, and the end of the axle pin is equipped with a tooth filling switch, wherein,

[0056] The tooth filling switch is located on the outer side of the glue gun.

[0057] As a preferred technical solution of the present invention, a tensioner is installed on the top of the driven rack, wherein:

[0058] The driven rack passes through the glue gun.

[0059] The present invention provides a medical adhesive delivery system, comprising the aforementioned delivery device, wherein a movable groove is provided inside the glue gun, wherein:

[0060] A pull-out limiting device is installed in the movable groove;

[0061] The pull-out limiting device includes a straight-insertion limiting plate or a screw-type limiting plate, wherein:

[0062] A card block is installed on the direct-insertion limit plate;

[0063] A third rebound spring is installed on the connecting bolt between the trigger and the active rack;

[0064] A third tensioner is installed at the bottom of the driven rack, wherein

[0065] An elastic fixing block is provided between the third tensioner and the driven rack.

[0066] The present invention also provides a medical adhesive for use in the aforementioned delivery device or delivery system, comprising: a closed main component, a plasticizer, a thickener, and an inhibitor, which are mixed.

[0067] More preferably, the main component agent includes one or more of α-ethyl cyanoacrylate, α-isoethyl cyanoacrylate, α-butyl cyanoacrylate, α-isobutyl cyanoacrylate, α-octyl cyanoacrylate, and α-isooctyl cyanoacrylate;

[0068] The plasticizer includes one or more of polyethylene glycol dioleate, tributyl citrate, dioctyl terephthalate, dioctyl sebacate, synthetic plant esters, methyl palmitate, epoxy soybean oil, acetyl tributyl citrate, acetyl triethyl citrate, polyethylene glycol monomethyl ether, and tributyrin;

[0069] The thickener includes one or more of polyvinyl pyrrolidone, polymethyl methacrylate, polybutyl acrylate, chitosan, gelatin, soluble starch, sodium carboxymethyl cellulose, cellulose acetate butyrate, carboxymethyl cellulose, and ethylene-vinyl acetate copolymer;

[0070] The polymerization inhibitor includes one or more of hydroquinone, succinic acid, malic acid, citric acid, phosphoric acid, glacial acetic acid, methanesulfonic acid, phytic acid, and polyglutamic acid.

[0071] The beneficial effects achieved by the present invention are: the present invention adopts a spring as the elastic part of the glue gun, which has the characteristics of fatigue resistance and increased service life; it can achieve quantitative extrusion and repeated use; the marking catheter has a first mark and a second mark, which achieves precise positioning and makes it possible to know the length of the catheter that penetrates into human tissue; the structure is simple and the assembly difficulty is low; through the buckle ring design of the glue injector, the glue injection parts are reduced and the effect of extruding an equal amount of glue is achieved. BRIEF DESCRIPTION OF THE DRAWINGS

[0072] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0073] Figure 1 It is one of the structural schematic diagrams of the present invention;

[0074] Figure 2 It is one of the structural schematic diagrams of the present invention;

[0075] Figure 3 It is one of the structural schematic diagrams of the present invention;

[0076] Figure 4 It is one of the structural schematic diagrams of the present invention;

[0077] Figure 5 It is one of the structural schematic diagrams of the present invention;

[0078] Figure 6 It is one of the structural schematic diagrams of the present invention;

[0079] Figure 7 It is one of the structural schematic diagrams of the present invention;

[0080] Figure 8 It is one of the structural schematic diagrams of the present invention;

[0081] Figure 9 It is one of the structural schematic diagrams of the present invention;

[0082] Figure 10 It is one of the structural schematic diagrams of the present invention;

[0083] Figure 11 It is one of the structural schematic diagrams of the present invention;

[0084] Figure 12 It is one of the structural schematic diagrams of the present invention;

[0085] Figure 13 It is one of the structural schematic diagrams of the present invention;

[0086] Figure 14 It is one of the structural schematic diagrams of the present invention;

[0087] Figure 15 It is one of the structural schematic diagrams of the present invention;

[0088] Figure 16 It is one of the structural schematic diagrams of the present invention;

[0089] Figure 17 It is one of the structural schematic diagrams of the present invention;

[0090] Figure 18 It is one of the structural schematic diagrams of the present invention;

[0091] Figure 19 It is one of the structural schematic diagrams of an embodiment of the present invention;

[0092] Figure 20 It is one of the structural schematic diagrams of an embodiment of the present invention;

[0093] Figure 21 It is one of the structural schematic diagrams of an embodiment of the present invention;

[0094] Figure 22 It is one of the structural schematic diagrams of the present invention;

[0095] Figure 23 It is one of the structural schematic diagrams of the present invention;

[0096] Figure 24 It is one of the structural schematic diagrams of the present invention;

[0097] In the figure: 1. Marking catheter; 2. Glue injection tube; 3. Glue injector; 4. Glue gun; 11. Marking catheter connector; 12. Marking catheter handle; 13. First mark; 14. Second mark; 21. First connector of glue injection tube; 22. Glue injection tube handle; 23. Second connector of glue injection tube; 24. Glue injection tube fitting; 25. Developing device; 31. Glue injection chamber; 32. Snap ring; 33. Glue injection piston; 34. Piston locking teeth; 35. Glue injection hole; 321. Snap ring limit block; 322. Snap ring locking block; 323. Snap ring locking teeth; 324. Bending point; 325. Second locking block of snap ring; 326. Snap ring locking groove; 41. Glue gun connecting groove; 42. Active rack; 43. Driven rack; 44. Trigger; 45. Rebound spring; 46. Limit plate; 47. Trigger limit column; 48. Tooth filling switch; 49. Second rebound spring; 410. Raised column; 411. Hole slot; 412. Tensioner; 413. Third tensioner; 4131. Elastic fixing block; 414. Pull-out limit device; 4141. Direct plug-in limit plate; 41411. Block; 4142. Spiral limit plate; 415. Moving groove; 416. Third rebound spring; 5. Housing; 51. Pressure ring; 52. Liquid outlet pipe; 53. First one-way valve; 54. Second one-way valve; 55. Spring; 56. Connecting pipe; 57. Storage chamber. DETAILED DESCRIPTION

[0098] The preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood that the preferred embodiments described herein are only used to illustrate and explain the present invention, and are not used to limit the present invention.

[0099] Example 1

[0100] like Figure 1-2 As shown, the present invention provides a medical adhesive, a delivery device, and a delivery system. This embodiment 1 provides a delivery device, including a marking catheter 1 and a glue injection tube 2, wherein the marking catheter 1 is connected to the glue injection tube 2. The glue injection tube 2 is provided with a standard Luer connector (i.e., a first glue injection tube connector 21) from the left end, which is convenient for assembly with a glue injector 3. A glue injection tube handle 22 is provided between the first glue injection tube connector 21 and the second glue injection tube connector 23, which serves as a grip when the glue injection tube 2 and the glue injector 3 are rotatably assembled. A Luer nut connector (i.e., the second glue injection tube connector 23) is assembled with the head end of the glue injection tube fitting 24.

[0101] The outer surface of the marking catheter 1 is provided with a first mark 13 and a second mark 14, wherein the second mark 14 is distributed between the first marks 13. In this embodiment, the first mark 13 is a marking mark and the second mark is a digital mark. Starting from the head end, there will be marking marks (i.e., first marks 13) at the same intervals on the marking catheter 1 pipe. At the same time, digital marks (i.e., second marks 14) will be engraved at a distance of 10mm, 20mm...80mm from the head end. The above two marks are used to measure the length of the marking catheter 1 and the injection tube 2 penetrating into the human body and the consistency of the intervals between the injection points in the vein.

[0102] A first glue injection tube joint 21 and a second glue injection tube joint 23 are installed at the end of the glue injection tube 2 , wherein the glue injection tube 2 is connected to the marking catheter 1 via the second glue injection tube joint 23 .

[0103] A glue injection tube fitting 24 is installed at one end of the glue injection tube 2, wherein a developing device 25 is provided on the glue injection tube fitting 24, and the developing device 25 is specifically a developing point or a developing ring, and the material is a special metal material. The special metal material in this embodiment is preferably platinum iridium metal or tantalum metal. The developing point or the developing ring has a calibrated distance at the starting end and the end end of the glue injection tube fitting 24, so that the position of the head end of the glue injection tube fitting 24 in the venous tissue can be measured under the developing equipment; the material of the glue injection tube fitting 24 can be selected from materials including but not limited to PTFE, and the diameter of the glue injection tube fitting 24 is smaller than the diameter of the marking catheter 1, so that the glue injection tube fitting 24 can be inside the marking catheter 1; the material of the marking catheter 1 can be selected from materials including but not limited to PE, and the diameter of the marking catheter 1 should be larger than the glue injection tube 2, so that it can be sleeved outside the glue injection tube 2.

[0104] The second joint 23 of the injection tube is connected to the marking tube joint 11 (standard Luer joint) at the end of the marking tube 1, thereby connecting the injection tube fitting 24 and the marking tube 1. A marking tube grip 12 is installed on the marking tube 1 on one side of the marking tube joint 11, which plays a gripping role when the marking tube 1 and the injection tube 2 are rotatably assembled.

[0105] Specifically, the conveying device (ie, the glue injection device) of this embodiment can ensure that the length of the measuring marking catheter 1 and the glue injection tube 2 inserted into the human body and the intervals between the glue injection points in the vein are consistent.

[0106] Example 2

[0107] like Figure 3-7 As shown, this embodiment provides a medical adhesive delivery system, including the delivery device of Example 1, wherein the first joint 21 of the injection tube at the end of the injection tube 2 is connected to the injection device 3, wherein the injection device 3 includes an injection cavity 31, a buckle ring 32, an injection piston 33, piston teeth 34 and an injection hole 35;

[0108] The glue injector 3 is provided with a glue injection cavity 31 inside which a glue injection piston 33 is installed. The left end of the glue injection cavity 31 is a Luer connector for easy assembly with the glue injection tube 2. The glue injection cavity 31 is smooth and uniform, ensuring that the glue injection piston 33 moves liquid-tightly.

[0109] A buckle ring 32 is installed at the end of the glue injector 3, and a piston locking tooth 34 is provided on the glue injection piston 33; a glue injection hole 35 is provided at the end of the glue injection cavity 31 to ensure the extrusion of the special sealing agent.

[0110] The snap ring 32 is snapped into the end flange of the glue injector 3, wherein a snap ring limit block 321 is provided at one end of the snap ring 32, and the snap ring limit block 321 is installed in the groove of the end flange of the glue injector 3;

[0111] The other end of the snap ring 32 is provided with a snap ring tooth 323 , wherein a snap ring locking block 322 is provided on the inner side of the snap ring 32 close to the flange of the glue injector 3 .

[0112] The retaining ring limiter 321 is limited to a certain range of movement within the slot on the injection handle of the glue injector 3. The retaining ring teeth 323 are designed to engage with the teeth on the piston 33 of the glue injector 3. The lateral length of the retaining ring teeth 323 should be less than the lateral length of the piston teeth. In this embodiment, the retaining ring 32 preferably has six teeth arranged in a circular array, and the retaining portion has an inclined groove to prevent the injection piston 33 from retreating. When the retaining ring 32 moves until it engages with the teeth of the injection piston 33, the raised retaining ring locking block 322 on the retaining ring 32 mates with the recessed locking block on the injection handle, completing the locking action.

[0113] In another preferred embodiment of the present invention, a second locking block 325 of the snap ring is provided on the outer side of the snap ring 32, wherein a bending point 324 of the snap ring 32 is provided on one side of the second locking block 325 of the snap ring; and a snap ring locking groove 326 is provided on the snap ring 32 on the same side as the second locking block 325 of the snap ring.

[0114] The limit block design is cancelled, and the locking of the buckle ring 32 is completed by bending operation. When the injection piston 33 is pushed into the cavity, the buckle ring 32 is bent until the second locking block 325 of the buckle ring is sunk into the buckle ring locking groove 326 to complete the locking.

[0115] The left end of the injection piston 33 is made of rubber. To ensure a good liquid-tight effect, the middle section of the injection piston 33 is provided with a tooth (a snap ring tooth 323). The distance between the teeth is set in relation to the cross-sectional area of the injection tube cavity 31 of the injector 3, ensuring that a fixed amount of glue can be squeezed out for each movable distance of the injection piston 33. The depth of the tooth on the piston shaft matches the tooth of the snap ring 32, and should not be too loose or too tight. The injection piston handle is provided with an anti-slip strip to prevent sliding during the advancement process and affecting the glue volume, i.e. Figure 7 shown.

[0116] Example 3

[0117] like Figure 8 As shown, this embodiment provides a medical adhesive delivery system, including the delivery device of Example 1, wherein the first connector 21 of the injection tube 2 is connected to the connecting tube end assembly 561 of the press-type injection device, wherein the press-type injection device includes a housing 5;

[0118] A storage chamber 57 is provided in the shell 5, wherein a pressure ring 51 is installed at the top of the shell 5; a liquid outlet pipe 52 passes through the pressure ring 51, wherein a first one-way valve 53 and a second one-way valve 54 are installed in the liquid outlet pipe 52; a spring 55 is provided between the first one-way valve 53 and the second one-way valve 54; a connecting pipe 56 is installed at the end of the pressure ring 51, wherein the connecting pipe 56 is connected to the liquid outlet pipe 52; a connecting pipe end assembly 561 is installed at the end of the connecting pipe 56 to achieve communication with the injection pipe 2.

[0119] Specifically, during use, the colloid is placed in the box body 5. When the colloid is needed, the palm of one hand presses the pressing ring 51, and the liquid outlet pipe 52 drives the first one-way valve 53 to move downward. The spring 55 is compressed, and the space between the first one-way valve 53 and the second one-way valve 54 becomes smaller, and the pressure increases, causing the first one-way valve 53 to open and allow the colloid to pass through. When the palm leaves the pressing ring 51, under the action of the spring, the liquid outlet pipe 52 moves upward, the space between the two one-way valves becomes larger, and the second one-way valve 54 is opened, and the colloid in the box body is sucked into the space between the two one-way valves, completing the colloid suction. When using it for the first time, you can press it several times to fill the liquid outlet pipe. The structure of the colloid storage device that sprays from the side allows the colloid to be sprayed from above to a position at the height of the palm. The colloid can be pressed out stably with one hand, which is more convenient to operate. Combined with the catheter 6, quantitative colloid output can be achieved.

[0120] Example 4

[0121] like Figure 9-12 、 Figure 18 、 Figure 22-24As shown, this embodiment provides a medical adhesive delivery system, which differs from Example 2 in that the glue injector 3 is connected to the glue gun connecting groove 41 at the end of the glue gun 4 through the glue injector cylinder seat at its end, wherein the other end of the glue injection piston 33 is connected to the driven rack 43 inside the glue gun 4 and can be driven by the driven rack 43. The glue injection piston 33 is pushed in an equal distance to control the quantitative amount of glue output;

[0122] The driven rack 43 is meshed with the active rack 42. The active rack 42 is mounted on the top of the trigger 44 via a shaft pin;

[0123] A cavity is provided in the handle of the glue gun 4, and a limit plate 46 is fixed to the bottom of the cavity. A rebound spring 45 is provided between the trigger 44 and the limit plate 46. A trigger limit post 47 is provided on one side of the trigger 44, wherein the trigger limit post 47 is provided on the inner wall of the cavity in the handle of the glue gun 4.

[0124] An axle pin is installed at the end of the active rack 42, and a tooth filling switch 48 is installed at the end of the axle pin, wherein the tooth filling switch 48 is located on the outer side of the glue gun 4; when the tooth filling switch 48 is toggled downward, the tooth filling switch 48 drives the active rack 42 to move downward, leaving a gap for the driven rack 43 to be inserted, the driven rack is inserted to the bottom, and then the glue injector is inserted into the slot and rotated to fix it to complete the assembly.

[0125] Specifically, the tooth density of the active rack 42 in the glue gun 4 is consistent with that of the driven rack 43, achieving a transmission effect between them. Before the trigger 44 is pulled, the end of the active rack 43 is acted upon by a tension spring, which keeps the active rack 42 in an upward position. In this structure, the upper end of the limit plate 46 also serves to limit the active rack 42, preventing it from tilting too high.

[0126] The trigger 44 in the glue gun 4 adopts an ergonomic structural design and has an anti-slip effect. A concentric shaft hole is provided at the upper end of the trigger 44, which matches the concentric axis of the active rack 42. When the trigger 44 is pulled, the active rack 42 will move in an approximately circular motion, giving a transmission effect to the driven rack 42. When the trigger 44 hits the trigger limit column 47, the trigger 44 stops moving. The trigger limit column 47 is controllable. The larger the diameter of the trigger limit column 47, the smaller the stroke of the trigger 44 and the smaller the travel of the active rack. A rebound spring 45 is provided at the tail end of the middle section of the trigger 44. After the rebound spring 45 hits the limit plate 46, it gives a rebound effect after the trigger 44 is pulled.

[0127] When the trigger 44 is pulled, it drives the active rack 42 in a substantially circular motion. The driven rack 43, due to interlocking with the active rack 42, moves leftward. The driven rack 43 contacts the injector piston handle, pushing the piston leftward and extruding a predetermined amount of medical adhesive. When the rebound spring of the trigger 44 contacts the right limit plate to a certain extent, the trigger 44 returns to its initial position.

[0128] The tensioner 412 in the glue gun 4 applies lateral pressure to the driven rack 43 through two tension plates, preventing it from moving backward during forward motion. After the driven rack 43 reaches its left limit, the tooth-filling switch 48 is toggled downward. This coaxially drives the active rack 42 downward, releasing the tooth-engaging area and allowing the driven rack 43 to move freely to the right. After the tooth-filling switch 48 returns to its original position, the active rack 42 reengages the driven rack 43, allowing the lower wheel to propel forward.

[0129] The tooth density parameters of the driven rack 43 and the active rack 42 are calculated based on the adhesive extrusion rate. The driven rack advances, and its advancement is limited by the trigger limiter 47. This pushes the injection piston 33 connected to the glue gun 4 forward, completing the precise amount of adhesive extrusion. Each pull of the trigger 44 ensures the same amount of adhesive is extruded, meeting the technical requirements of venous closure surgery.

[0130] In another preferred embodiment of the present invention, the active rack 42 is mounted on the top of the trigger 44 through a shaft pin; a cavity is provided in the handle of the glue gun 4, and a limit plate 46 is fixed to the bottom of the cavity, wherein a raised column 410 is installed on one side of the limit plate 46 to adapt to the circular motion of the trigger 44; a second rebound spring 49 is sleeved on the raised column 410 to give the trigger 44 a rebound effect (the diameter of the second rebound spring 49 is larger than the diameter of the cylinder, i.e., the raised column 410), wherein a hole groove 411 corresponding to the raised column 410 is provided on the side of the trigger 44 opposite to the raised column 410, to leave space for the cylinder to enter after the second rebound spring 49 is compressed, and the diameter is smaller than the diameter of the second rebound spring 49, but larger than the diameter of the cylinder (the raised column 410);

[0131] An axle pin is installed at the end of the active rack 42 , and a tooth filling switch 48 is installed at the end of the axle pin, wherein the tooth filling switch 48 is located on the outer side of the glue gun 4 .

[0132] Furthermore, in embodiment 4 and another embodiment included in embodiment 4, a tensioner 412 is installed on the top of the driven rack 43 , wherein the driven rack 43 passes through the glue gun 4 .

[0133] Example 5

[0134] like Figure 13-17As shown, this embodiment provides a medical adhesive delivery system, which differs from the second embodiment in that a movable groove 415 is provided inside the glue gun 4, wherein a pull-out limit device 414 is installed in the movable groove 415, and the tooth filling switch 48 and the trigger limit column 47 are eliminated;

[0135] The pull-out limit device 414 includes a straight-insert limit plate 4141 or a spiral limit plate 4142, wherein the straight-insert limit plate 4141 is provided with a block 41411, which contacts the bottom of the shell to stop the pull-out movement; when the pull-out limit device 414 is a spiral limit plate 4142, it rotates out from the bottom of the glue gun 4 handle, as shown below Figure 17 shown.

[0136] A third rebound spring 416 is mounted on the connecting bolt between the trigger 44 and the active rack 42;

[0137] A third tensioner 413 is installed at the bottom of the driven rack 43 , wherein an elastic fixing block 4131 is provided between the third tensioner 413 and the driven rack 43 .

[0138] Specifically, after the pull-out limit device 414 is pulled downward, there is space for the trigger 44 to move to the right again. The trigger 44 is pulled again to the deep end of the housing of the glue gun 4. When the active rack 42 moves in a circular motion to peel off the biting area, a free gap is given to the driven rack 43, so that the driven rack 43 can freely enter and exit the housing of the glue gun 4. Figure 14 The trigger 44 is shown in the schematic diagram. A limit plate moving groove 415 is provided on the housing (i.e., a moving groove 415 is provided inside the glue gun 4), which allows the pull-out limit device 414 to move within a certain range and come into contact with the bottom of the housing to stop the pull-out movement. In order to allow the trigger 44 to have room to move, the trigger limit column 47 is removed from the housing. Figure 15 As shown, a third rebound spring 416 is installed on the connecting bolt between the trigger 44 and the active rack 42. One end of the third rebound spring 416 abuts against the trigger 44, and the other end abuts against the active rack 42, so that the active rack 42 remains in an upward state when moving forward, and the head of the active rack 42 has a certain elasticity. Figure 16 As shown, a third tensioner 413 is installed at the bottom of the driven rack 43, and an elastic fixing block 4131 is provided between the third tensioner 413 and the driven rack 43. The left and right elastic fixing blocks elastically clamp the middle driven rack 43 to prevent it from moving backward during movement.

[0139] All embodiments included in Examples 4-5 can achieve quantitative extrusion of adhesives, and the contents in different structural modes can be replaced with each other, but should all fall within the scope of protection of this patent.

[0140] Specifically, in Examples 2-5, the detailed operations of the glue injection tube 2 dispensing glue in equal amounts through the three methods of the press-type glue injector, the glue injector 3, and the combination of the glue injector 3 and the glue gun 4 are as follows: Figure 19 As shown, after vascular access is established, a dilator is used to pre-dilate the vascular pathway. Once vascular access is established, the injection tube 2 and marking catheter 1 are guided along the venous entrance to the designated occlusion area under ultrasound observation (the imaging device 25 of the injection tube 2 facilitates precise positioning). The injection handle (injection piston 33) at the rear end of the injector 3 is pushed, or the pressure ring 51 of the push-type injector in Example 3 is pressed. The injection piston 33 pushes the cavity to eject a predetermined amount of special sealing adhesive. The external downward restraining force then collapses the vein, and the special sealing adhesive adheres to the vessel under the external pressure. The injection process is terminated when the injection piston 33 and the piston teeth 34 of the injector 3 engage, or when the pressure ring 51 of the push-type injector in Example 3 has only been pressed once. After a period of stasis, the occlusion area is closed, and the injection tube 2 is withdrawn and moved to a distance from the forward injection point. At the same time, move the ultrasonic sensor to confirm the position of the glue injection tube 2 again, and push the glue injector 3 to spray out an equal amount of special closing adhesive; Figure 20 As shown, after the vascular access is established, the vascular access needs to be pre-expanded with a dilator. After the vascular access is established, under the observation of the ultrasound instrument, the glue injection tube 2 and the marking catheter 1 are moved along the venous entrance to the designated occlusion area (in this process, the developing device 25 of the glue injection tube 2 plays a role in precise positioning). Then, the trigger 44 of the glue gun 4 is pulled, and the driven rack 43 pushes the glue injection piston 33 of the glue injector 3 to move so that the glue injector 3 sprays out a certain amount of special closing adhesive, and then uses the external downward restraining force to cause the vein to collapse downward. The special closing adhesive adheres to the blood vessel under the action of external pressure. After standing for a period of time and the blood vessels in the occluded area are closed, the glue injection tube 2 is pulled out and moved to a certain distance from the front glue injection point. At the same time, the ultrasonic sensor is moved to confirm the position of the glue injection tube 2 again, and the glue injector 3 is pushed to spray out an equal amount of special closing adhesive, as shown in FIG. Figure 21 shown.

[0141] The distance the injection tube 2 is withdrawn should be based on the exposed markings on the marker catheter 1. Repeat the above steps until the designated occlusion area is completely closed. The closure of the designated venous occlusion area can also be determined by ultrasound imaging. The injection tube 2 and marker catheter 1 assembly can then be removed.

[0142] This embodiment is not only applicable to varicose veins of the lower extremities, but can also be used for closure surgeries of veins, arteries, lymphatic vessels or other artificial body cavities, including closure of capillary dilation, vascular and non-vascular fistulas and fallopian tubes.

[0143] The present invention also provides a medical adhesive (i.e., the special closing adhesive in Examples 1 to 5), which is applied to the aforementioned delivery device or delivery system, and its components include: a closing main component agent, a plasticizer, a thickener, and an inhibitor, which are mixed.

[0144] Specifically, the main component agent includes one or more of α-ethyl cyanoacrylate, α-isoethyl cyanoacrylate, α-butyl cyanoacrylate, α-isobutyl cyanoacrylate, α-octyl cyanoacrylate, and α-isooctyl cyanoacrylate;

[0145] The plasticizer includes one or more of polyethylene glycol dioleate, tributyl citrate, dioctyl terephthalate, dioctyl sebacate, synthetic plant esters, methyl palmitate, epoxy soybean oil, acetyl tributyl citrate, acetyl triethyl citrate, polyethylene glycol monomethyl ether, and tributyrin;

[0146] The thickener includes one or more of polyvinyl pyrrolidone, polymethyl methacrylate, polybutyl acrylate, chitosan, gelatin, soluble starch, sodium carboxymethyl cellulose, cellulose acetate butyrate, carboxymethyl cellulose, and ethylene-vinyl acetate copolymer;

[0147] The polymerization inhibitor includes one or more of hydroquinone, succinic acid, malic acid, citric acid, phosphoric acid, glacial acetic acid, methanesulfonic acid, phytic acid, and polyglutamic acid.

[0148] A single injection of a special occlusive adhesive can be between 0.1 ml and 1.0 ml, and two separate injections can be injected at a distance within the vessel of between 0.5 cm and 5 cm.

[0149] The conveying device is the glue injection device, and the conveying system is the glue injection system.

[0150] The present invention adopts a spring as the elastic part of the glue gun, which has the characteristics of fatigue resistance and increased service life; it can achieve quantitative extrusion and repeated use; the first mark and the second mark are provided on the marking catheter, which achieves precise positioning and makes it possible to know the length of the catheter penetrating into human tissue; it has a simple structure and low assembly difficulty; through the buckle ring design of the glue injector, it is possible to reduce the number of glue injection parts and achieve the effect of extruding an equal amount of glue.

[0151] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or substitute equivalents for some of the technical features. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A medical adhesive delivery system, characterized in that: The invention comprises a conveying device, wherein the conveying device comprises a marking catheter (1) and a glue injection tube (2), wherein: The marking catheter (1) is connected to the glue injection tube (2); The outer surface of the marking catheter (1) is provided with a first mark (13) and a second mark (14), wherein: The second marks (14) are distributed between the first marks (13); The end of the glue injection pipe (2) is equipped with a first glue injection pipe joint (21) and a second glue injection pipe joint (23), wherein: The glue injection tube (2) is connected to the marking catheter (1) via the glue injection tube second joint (23); The first glue injection pipe joint (21) at the end of the glue injection pipe (2) is connected to a glue injector (3), wherein: The glue injector (3) comprises a glue injection cavity (31), a buckle ring (32), a glue injection piston (33), piston locking teeth (34) and a glue injection hole (35); The glue injector (3) is provided with a glue injection cavity (31) inside, wherein: A glue injection piston (33) is installed in the glue injection cavity (31); A buckle ring (32) is installed at the end of the glue injector (3), and a piston locking tooth (34) is provided on the glue injection piston (33), wherein: The end of the glue injection cavity (31) is provided with a glue injection hole (35); The snap ring (32) is snapped into the end flange of the glue injector (3), wherein: A snap ring limiting block (321) is provided at one end of the snap ring (32), and the snap ring limiting block (321) is installed in a groove of the end flange of the glue injector (3); The other end of the buckle ring (32) is provided with a buckle ring tooth (323), wherein: A buckle ring locking block (322) is provided on the inner side of the buckle ring (32) close to the flange of the glue injector (3).

2. A medical adhesive delivery system according to claim 1, characterized in that: One end of the glue injection pipe (2) is installed with a glue injection pipe fitting (24), wherein: The glue injection pipe (24) is provided with a developing device (25); The second joint (23) of the glue injection tube is connected to the marking catheter joint (11) at the end of the marking catheter (1), wherein: A marking catheter handle (12) is installed on the marking catheter (1) on one side of the marking catheter connector (11); A glue injection tube handle (22) is provided between the first glue injection tube joint (21) and the second glue injection tube joint (23).

3. The medical adhesive delivery system according to claim 1, characterized in that: A second locking block (325) of the buckle ring is provided on the outside of the buckle ring (32), wherein: A bending point (324) of the buckle ring (32) is provided on one side of the second locking block (325) of the buckle ring; A buckle ring locking groove (326) is provided on the buckle ring (32) on the same side as the buckle ring second locking block (325).

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