Methods for preparing and purifying acetic acid-D
By reacting deuterium bromide with sodium acetate in a heavy water system to generate acetic acid-D, and then using polar organic solvent extraction and vacuum distillation, the high temperature, high pressure, and high cost problems of existing hydrogen-deuterium exchange reactions were solved, and the preparation and purification of high-purity acetic acid-D was achieved.
Patent Information
- Application Number
- CN202211456724.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-11-21
- Publication Date
- 2026-03-10
- Estimated Expiration
- 2042-11-21
AI Technical Summary
Existing hydrogen-deuterium exchange reactions require high temperature and high pressure conditions, have low selectivity and conversion rates, and the high cost of precious metal catalysts limits the large-scale industrial application of deuterated chemicals.
In a heavy water system, acetic acid-D is generated by the chemical reaction of deuterium bromide and sodium acetate. It is then extracted with a polar organic solvent and purified by vacuum distillation at room temperature, avoiding the use of a catalyst and resulting in mild reaction conditions.
The efficient synthesis and purification of acetic acid-D were achieved, with a hydroxyl deuteration rate of up to 99.01% and a purity of up to 99.8%, reducing costs and simplifying equipment requirements.