Rfid-based pathological whole process management method and pathological management system therefor
By using RFID technology for information management throughout the entire pathology process, the problem of insufficient full-process monitoring in the pathology management system has been solved, achieving high-efficiency and low-error-rate pathology management.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- THE FIRST AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
- Filing Date
- 2022-11-04
- Publication Date
- 2026-06-02
AI Technical Summary
Existing pathology management systems cannot achieve full-process monitoring, leading to an increased risk of errors and loss, especially in the sectioning stage where information management is insufficient.
By using RFID technology to read information throughout the entire process of pathological tissue sampling, embedding, sectioning, mounting, and archiving, and inputting this information along with relevant data into the pathology management system, the entire process can be managed with information technology.
It improved the efficiency of pathology management, reduced the error rate, and prevented medical accidents such as tissue loss and incorrect replacement.
Smart Images
Figure CN115831301B_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of pathological data management, and more specifically, to an RFID-based method for managing the entire pathological process and a pathological management system for use therein. Background Technology
[0002] In the current pathology management process, the first step is to collect samples and input the sampling information into the pathology information system. Then, the collected samples are dehydrated and embedded. Next, the embedded cassettes are sectioned and sealed. Diagnosis is then performed based on the slides obtained after sealing, and finally, the samples are archived.
[0003] Currently, a new type of embedding cassette has been applied in pathology management. It uses electronic tags with RFID chips to electronically label the pathology number of the embedding cassette and attach electronic markers indicating whether each processing step has been completed. This enables strict monitoring of each step in the embedding cassette preparation process, while also making the archiving process faster, more accurate, and more convenient.
[0004] However, currently, this type of embedding cassette is only used to realize the transition from handwriting to the current embedding cassette numbering and slide numbering, as well as the transition from oral description to reading with a barcode scanner. Information management is only carried out in the slicing process. Although it reduces the occurrence of errors, it cannot achieve full-process monitoring and eliminate the occurrence of errors.
[0005] Therefore, it is desirable to provide an RFID-based solution for the entire pathology management process. Summary of the Invention
[0006] This application provides an RFID-based method for managing the entire pathological process and a pathological management system therefor. The method reads RFID information and inputs it into the pathological management system along with relevant information during the entire process of pathological tissue sampling, embedding, sectioning, mounting, reading, and archiving, thereby achieving efficient and low-error-rate management of the entire pathological process.
[0007] According to one aspect of this application, a pathological process management method based on RFID is provided, comprising: taking pathological tissue samples and generating RFID information on an embedding cassette; embedding the pathological tissue and the embedding cassette, and inputting the RFID information and embedding management information regarding the embedding process into a pathological management system; performing sectioning, staining, and mounting operations on the embedded pathological tissue to obtain sections of the pathological tissue and generating RFID information thereon, and inputting the RFID information read from the embedded pathological tissue, along with section management information and paraffin block management information regarding the sectioning, staining, and mounting operations, into the pathological management system; determining personnel information related to the paraffin block or section of the pathological tissue and inputting the RFID information read from the paraffin block or section of the pathological tissue, along with the personnel information, into the pathological management system; and performing archiving and storage operations on the paraffin block and section of the pathological tissue, and inputting the RFID information read from the paraffin block and section of the pathological tissue, along with archiving and storage management information regarding the archiving and storage operations, into the pathological management system.
[0008] In the above-mentioned RFID-based pathological whole-process management method, after the pathological tissue sampling process, it further includes: post-sampling processing of the sampled pathological tissue, wherein the post-sampling processing includes pathological tissue dehydration.
[0009] In the above-mentioned RFID-based pathology whole-process management method, the post-processing of pathological tissues after sampling includes: reading the RFID information of the embedding cassette containing the pathological tissues through a device used for post-processing and verifying the information.
[0010] In the above-mentioned RFID-based pathology whole-process management method, the post-processing of pathological tissues after sampling includes: inputting post-processing management information related to the post-processing into the pathology management system.
[0011] In the above-mentioned RFID-based pathological process management method, after embedding the pathological tissue and the embedding box, the method further includes: confirming whether the pathological tissue after sampling and processing is completely consistent with the pathological tissue after embedding.
[0012] In the aforementioned RFID-based pathology process management method, the sectioning operation of the embedded pathological tissue includes: generating new RFID information on the slide; performing post-processing on the sectioned pathological tissue, including spreading, baking, staining, and mounting; and inputting post-processing management information regarding the sectioning process into the pathology management system. The post-processing includes spreading, baking, staining, and mounting the sections.
[0013] In the above-mentioned RFID-based pathological process management method, after the embedded pathological tissue is sectioned, stained, and mounted, the method further includes: determining whether the pathological tissue in the sectioned tissue and the pathological tissue in the mounted tissue are completely consistent.
[0014] In the above-mentioned RFID-based pathology process management method, after the archiving operation of the pathological tissue slides, the method further includes: reading the RFID information of the archived slides or paraffin blocks that need to be borrowed, and inputting them into the pathology management system together with the borrowing management information regarding the borrowing operation.
[0015] According to another aspect of this application, a pathology management system is provided, comprising: an embedding management information unit for managing RFID information of the collected pathological tissue and its embedding cassette, and embedding management information regarding the embedding operation of the pathological tissue; a slide management information unit for managing RFID information read from the embedded pathological tissue and generating new RFID information on a glass slide, and slide management information and paraffin block management information regarding the slide, staining, and mounting operations; a personnel management information unit for managing personnel information related to the slides of the pathological tissue; and an archiving and preservation management unit for archiving and preservation management information regarding the archiving and preservation operations of the slides and paraffin blocks of the pathological tissue.
[0016] In the aforementioned pathology management system, the archiving and preservation management unit 240 is further used to manage the borrowing management information regarding the archived and preserved slides.
[0017] The RFID-based pathology process management method and pathology management system provided in this application embodiment can achieve high-efficiency and low-error-rate pathology process management by reading RFID information and inputting it into the pathology management system along with relevant information during the entire process of pathological tissue sampling, embedding, sectioning, spreading, baking, staining, mounting, reading, and archiving. Attached Figure Description
[0018] Various other advantages and benefits of this application will become apparent to those skilled in the art upon reading the detailed description of the preferred embodiments below. The accompanying drawings are for illustrative purposes only and are not intended to limit the scope of this application. It is obvious that the drawings described below are merely some embodiments of this application, and those skilled in the art can obtain other drawings based on these drawings without any inventive effort. Furthermore, the same reference numerals denote the same parts throughout the drawings.
[0019] Figure 1 The illustration shows a schematic flowchart of an RFID-based pathology process management method according to an embodiment of this application.
[0020] Figure 2 The illustration shows a schematic diagram of specimen collection information details according to an embodiment of this application.
[0021] Figure 3 The illustration shows a schematic diagram of an RFID reader / writer built into an embedding box numbering machine according to an embodiment of this application.
[0022] Figure 4 The illustration shows a schematic diagram of a built-in RFID reader / writer in a dehydrator according to an embodiment of this application.
[0023] Figure 5 The illustration shows a schematic diagram of dehydration data according to an embodiment of this application.
[0024] Figure 6 The illustration shows a schematic diagram of an RFID reader / writer built into an embedding machine according to an embodiment of this application.
[0025] Figure 7 The illustration shows a schematic diagram of dehydration and embedding data according to an embodiment of this application.
[0026] Figure 8 The illustration shows a schematic diagram of the CLIP model used for pathological tissue comparison according to an embodiment of this application.
[0027] Figure 9 The illustration shows a schematic diagram of a slicer with a built-in RFID reader / writer according to an embodiment of this application.
[0028] Figure 10 The illustration shows a schematic diagram of an RFID tag printer according to an embodiment of this application.
[0029] Figure 11 The illustration shows a schematic diagram of the completed slice data according to an embodiment of this application. Figure 12 The illustration shows a schematic diagram of a baking tray and an RFID information reader according to an embodiment of this application.
[0030] Figure 13 The illustration shows a schematic diagram of the baking sheet data according to an embodiment of this application.
[0031] Figure 14 The illustration shows a schematic diagram of a sealing machine with a built-in RFID information reader according to an embodiment of this application.
[0032] Figure 15 The illustration shows a schematic diagram of staining data according to an embodiment of this application.
[0033] Figure 16 The illustration shows a schematic diagram of an RFID information reader according to an embodiment of this application.
[0034] Figure 17The illustration shows a schematic diagram of an optical microscope RFID information reader according to an embodiment of this application.
[0035] Figure 18 The illustration shows a schematic diagram of the data of a slice to be viewed according to an embodiment of this application.
[0036] Figure 19 The illustration shows a schematic diagram of diagnostic imaging data according to an embodiment of this application.
[0037] Figure 20 The illustration shows a schematic diagram of automatic batch reading of RFID information during the transfer of glass slides to the archives according to an embodiment of this application.
[0038] Figure 21 The illustration shows a schematic diagram of the automatic batch reading of RFID information during the transfer of wax blocks to the archives according to an embodiment of this application.
[0039] Figure 22 The illustration shows a schematic diagram of the automatic identification and saving of RFID information for the archiving location of glass slides according to an embodiment of this application.
[0040] Figure 23 The illustration shows a schematic diagram of the automatic identification and saving of RFID information for the archiving location of wax blocks according to an embodiment of this application.
[0041] Figure 24 The illustration shows a schematic diagram of the traceability information for the borrowing and handover of wax blocks / slices according to an embodiment of this application.
[0042] Figure 25 The illustration shows a schematic block diagram of a pathology management system for RFID-based pathology process management according to an embodiment of this application. Detailed Implementation
[0043] Hereinafter, exemplary embodiments according to this application will be described in detail with reference to the accompanying drawings. Obviously, the described embodiments are merely some embodiments of this application, and not all embodiments of this application. It should be understood that this application is not limited to the exemplary embodiments described herein.
[0044] Exemplary methods
[0045] For embedding cassettes with readable electronic tags such as QR codes, although tag scanning technology can be used to read the information, this technology can only complete the reading and identification of information through one-to-one scanning. In the process of preparing and managing pathological slides, if this method is used for identification at every step, it is not only slow and inefficient, but also prone to failure to recognize the QR codes due to processing issues (such as unclear QR code printing or paraffin impregnation). Furthermore, barcode scanning cannot be performed inside machines (such as dehydrators or staining and mounting machines) where the sample tissue is located. Therefore, the RFID-based pathology process management method according to the embodiments of this application utilizes RFID technology for automatic identification, enabling batch identification of embedding cassettes, which not only greatly improves efficiency but also achieves comprehensive, end-to-end management.
[0046] In other words, the RFID-based pathology process management method according to the embodiments of this application can be managed in an information-based manner from tissue sampling, through tissue dehydration, embedding, sectioning, staining, mounting, diagnosis, and record preservation, thereby eliminating medical accidents such as tissue loss or incorrect replacement that may occur during traditional methods.
[0047] The following will describe in detail the RFID-based pathology process management method according to embodiments of this application.
[0048] Figure 1 The illustration shows a schematic flowchart of an RFID-based pathology process management method according to an embodiment of this application.
[0049] like Figure 1 As shown, the RFID-based pathology whole-process management method according to the embodiments of this application includes the following steps.
[0050] Step S110 involves sampling the pathological tissue, generating its RFID information on the embedding cassette, embedding the pathological tissue and the embedding cassette, and inputting the RFID information and embedding management information related to the embedding process into the pathology management system. Specifically, the pathological tissue is first sampled, and according to the sampling details, the embedding cassette is printed and the RFID information of the pathological tissue is automatically written (e.g., using an embedding cassette with embedded RFID information and an all-in-one machine capable of printing the embedding cassette number and writing RFID information), thereby generating the RFID information of the sampled pathological tissue on the embedding cassette. Figure 2 and Figure 3 As shown. Here, Figure 2 The illustration shows a schematic diagram of specimen collection information details according to an embodiment of this application, and Figure 3 The illustration shows a schematic diagram of an RFID reader / writer built into an embedding box numbering machine according to an embodiment of this application.
[0051] In addition to the initial sampling and processing of pathological tissue, further post-sampling processing, such as dehydration, can be performed. Specifically, the embedding cassettes containing the processed pathological tissue are placed in a dehydrator. At this point, an RFID reader can be installed inside the dehydrator, for example, inside the dehydrator lid. When the lid is closed, the reader can read the information of all the embedding cassettes inside the dehydrator within a few seconds and transmit the data back to the pathology management system. Figure 4 and Figure 5 As shown. Here, Figure 4 The figure shows a schematic diagram of a dehydrator with a built-in RFID reader / writer according to an embodiment of this application. Figure 5 The illustration shows a schematic diagram of dehydration data according to an embodiment of this application.
[0052] In this way, the information of pathological tissues can be compared within the pathology management system, and the system can automatically display whether the information matches or does not match, which means that the information after tissue sampling can be verified. In addition, the system can also transmit post-sampling management information related to tissue processing, such as the dehydrator number, tissue processing procedure, reagent replacement status, actual machine temperature, personnel handing over the tissue sample, and tissue processing operators, back to the pathology management system and write it into the tissue processing information of each paraffin block formed by embedding.
[0053] Therefore, in the RFID-based pathological whole-process management method according to the embodiments of this application, after the pathological tissue is sampled, it further includes: post-sampling processing of the sampled pathological tissue, wherein the post-sampling processing includes pathological tissue dehydration.
[0054] Furthermore, in the RFID-based pathology whole-process management method according to the embodiments of this application, the post-processing of pathological tissue after sampling includes: reading the RFID information of the embedding cassette containing the pathological tissue through a post-processing device and verifying the information.
[0055] Furthermore, in the RFID-based pathology whole-process management method according to the embodiments of this application, post-processing of pathological tissues after sampling includes: inputting post-processing management information related to the post-processing into the pathology management system.
[0056] Then, the RFID information of the embedding cassette containing the pathological tissue is read and input into the pathology management system, and the pathological tissue is embedded. Specifically, an RFID reader can be installed at the wax outlet of the embedding machine. When the embedding cassette is near the wax outlet of the embedding machine, the embedding cassette information is automatically read. Here, the embedding cassette information includes not only pathological tissue information such as the number and size of the pathological tissue pieces in the embedding cassette, but may also further include embedding management information about the embedding process, such as embedding information and the embedding operator. Figure 6and Figure 7 As shown. Here, Figure 6 The figure shows a schematic diagram of an RFID reader / writer built into an embedding machine according to an embodiment of this application. Figure 7 The illustration shows a schematic diagram of dehydration and embedding data according to an embodiment of this application. This information is written together into the pathology management system, and after embedding, the pathology management system can also statistically analyze whether the post-processed pathological tissue and the embedded pathological tissue are completely consistent.
[0057] Therefore, in the RFID-based pathology whole-process management method according to the embodiments of this application, after embedding the pathological tissue and the embedding box, it further includes: confirming whether the pathological tissue after sampling and processing is completely consistent with the pathological tissue after embedding.
[0058] Here, when confirming whether the post-processed pathological tissue is completely consistent with the embedded pathological tissue, it can be done by comparing the RFID information corresponding to the post-processed pathological tissue and the embedded pathological tissue. However, since the RFID information at different stages includes different information, direct comparison is difficult, and comparison based solely on RFID information may result in inaccurate confirmation.
[0059] Based on this, in the technical solution of this application, by combining text data and image data read based on RFID information, the CLIP (Contrastive Language-Image Pre-Training) model is used to compare the pathological tissue after sampling and the pathological tissue after embedding. Figure 8 The illustration shows a schematic diagram of the CLIP model used for pathological tissue comparison according to an embodiment of this application. Figure 8 As shown, the CLIP model includes parallel text encoders and image encoders. It obtains a classification feature matrix for classification by encoding text data and image data and associating the obtained text feature vectors and image feature vectors. Then, the classification feature matrix is passed through a classifier to obtain the classification result.
[0060] Specifically, firstly, the RFID information of the post-processed pathological tissue and the embedded pathological tissue are obtained. A first text feature vector and a second text feature vector are obtained using a CLIP model text encoder. The difference between the first and second text feature vectors is calculated, i.e., the difference is made between the feature values at each position of the vectors, to obtain a differential text feature vector. Next, images of the post-processed and embedded pathological tissues are acquired. A first image feature vector and a second image feature vector are obtained using a CLIP model image encoder. The difference between the first and second image feature vectors is calculated to obtain a differential image feature vector. Then, the differential text feature vector (e.g., a row vector) is transposed and multiplied with the differential image feature vector (also a row vector) to obtain an association feature matrix as a classification feature matrix. Finally, the classification feature matrix is passed through a classifier, such as a softmax-based classifier, to obtain a classification result indicating whether the post-processed pathological tissue and the embedded pathological tissue are completely identical.
[0061] Furthermore, since the differential text feature vector and the differential image feature vector represent textual difference semantics and image difference semantics respectively, their feature distribution in the high-dimensional feature space may have spatial position errors. This can lead to a difference in the correspondence between the feature values of the corresponding positions of the differential text feature vector and the differential image feature vector when calculating the correlation feature matrix, thereby affecting the accuracy of the correlation feature matrix calculation.
[0062] Therefore, in the technical solution of this application, preferably before calculating the correlation feature matrix of the differential text feature vector and the differential image feature vector, the differential text feature vector and the differential image feature vector are corrected by relative class angle probability information representation, as follows:
[0063]
[0064]
[0065] and
[0066] in, and These are the feature values of the differential text feature vector V1 and the differential image feature vector V2, respectively. and These are the mean values of all feature values of the differential text feature vector V1 and the differential image feature vector V2, respectively, and log represents the logarithm to the base 2.
[0067] Here, the relative class angle probability information representation correction uses the relative class angle probability information representation between features to geometrically dilute the spatial position error of the feature distribution in the high-dimensional feature space. Thus, when there is a certain correlation between features, based on the boundedness of the feature value distribution at each position relative to the whole, implicit contextual correspondence correction of features is performed through point-by-point regression. This improves the correspondence between the feature values at corresponding positions of the differential text feature vector and the differential image feature vector, thereby improving the calculation accuracy of the associated feature matrix, and consequently, the accuracy of the classification result of the associated feature matrix.
[0068] Step S120: The embedded pathological tissue is sectioned, stained, and mounted to obtain a section of the pathological tissue and its RFID information is generated. The RFID information read from the embedded pathological tissue, along with the section management information and paraffin block management information regarding the sectioning, staining, and mounting operations, is then input into the pathology management system.
[0069] Specifically, the embedded pathological tissue is first sectioned, and the RFID information of the embedding cassette is read during sectioning. For example, an RFID reader can be installed at the chuck of the microtome, automatically reading the information of the embedding cassette when the paraffin block is clamped in the chuck. Here, in addition to the RFID information read such as the number and size of the tissue blocks in the embedding cassette, section management information related to the sectioning, such as sectioning information and the sectioning operator, can also be input into the pathology management system.
[0070] Simultaneously, the pathological tissue information of the slide can be transmitted to an RFID tag printer (with the function of printing numbers and writing RFID information) and the tag will be automatically (or manually) affixed to a blank glass slide, such as... Figure 9 , Figure 10 and Figure 11 As shown. Here, Figure 9 The figure shows a schematic diagram of a slicer with a built-in RFID reader / writer according to an embodiment of this application. Figure 10 The illustration shows a schematic diagram of an RFID tag printer according to an embodiment of this application, and Figure 11 The illustration shows a schematic diagram of the completed slice data according to an embodiment of this application.
[0071] In addition, post-section processing can be performed on the slides of the pathological tissue, such as spreading and baking the slides. Similarly, spreading and baking information can be read and recorded. Specifically, an RFID reader can be installed near the baking table of the slide spreading machine. After the slides are retrieved and placed on the baking table, the slide spreading machine automatically reads the information on the slides and writes post-section processing management information related to the slide spreading temperature, slide retrieval completion, baking temperature and time, and the operator who retrieved the slides into the pathology management system. Furthermore, an automatic wax sealing device can be installed on the baking table, along with an RFID reader, to automatically write the information that the wax block has been sealed into the pathology management system, such as... Figure 12 and Figure 13 As shown. Here, Figure 12 The illustration shows a schematic diagram of a baking tray and an RFID reader according to an embodiment of this application. Figure 13 The illustration shows a schematic diagram of the baking sheet data according to an embodiment of this application.
[0072] Therefore, in the RFID-based pathology whole-process management method according to the embodiments of this application, the sectioning operation of the embedded pathological tissue includes: performing post-sectioning processing on the sectioned pathological tissue, and inputting post-sectioning management information about the post-sectioning processing into the pathology management system. The post-sectioning processing includes at least one of the following: spreading the section, baking the section, and automatic wax sealing.
[0073] Next, the slides are mounted, and this mounting operation may include staining the slides. Specifically, an RFID reader can be installed on the mounting machine of the staining and mounting machine to read the information of the stained and mounted slides, and input mounting management information related to the mounting operation, such as the staining process of the staining machine, reagent replacement status, room temperature, and operator, into the pathology management system. Figure 14 and Figure 15 As shown. Here, Figure 14 The illustration shows a schematic diagram of a sealing machine with a built-in RFID information reader according to an embodiment of this application, and Figure 15 The illustration shows a schematic diagram of staining data according to an embodiment of this application. Furthermore, the pathology management system can determine whether the tissue block of the slide and the tissue block of the mounted slide completely match.
[0074] That is, in the RFID-based pathological whole-process management method according to the embodiments of this application, after the pathological tissue after embedding is sealed, it further includes: determining whether the pathological tissue of the slide and the pathological tissue of the sealed slide are completely consistent.
[0075] Here, those skilled in the art will understand that, when determining whether the pathological tissue of the slide and the pathological tissue of the mounting are completely consistent, the method described above for determining whether the pathological tissue after the sampling process is completely consistent with the pathological tissue after the embedding process can also be used.
[0076] Step S130: Determine the personnel information related to the slice of the pathological tissue and input the RFID information read from the slice of the pathological tissue along with the personnel information into the pathology management system.
[0077] For example, the pathological tissue slides can be handed over to the diagnosing physician. Specifically, the stained slides can be placed in front of an RFID information reader to read the slide information and enter the names of the technicians and receiving physicians into the pathology management system to complete the slide handover.
[0078] Furthermore, patient information can be read and entered while the diagnosing physician is reviewing slides. For example, by installing an RFID reader on the microscope stage, once a slide is placed on the stage, the pathology management system automatically switches to the page showing the patient whose slide is being reviewed. When completing the diagnostic review report, the pathology management system automatically checks the number of slides taken from that patient against the total number of slides reviewed to prevent missed slides. Figure 16 , Figure 17 , Figure 18 and Figure 19 As shown. Here, Figure 16 The figure shows a schematic diagram of an RFID information reader according to an embodiment of this application. Figure 17 The figure shows a schematic diagram of an RFID information reader for an optical microscope according to an embodiment of this application. Figure 18 The illustration shows a schematic diagram of the data of the slice to be viewed according to an embodiment of this application, and Figure 19 The illustration shows a schematic diagram of diagnostic imaging data according to an embodiment of this application.
[0079] Step S140 involves archiving and storing the pathological tissue slides and paraffin blocks, and inputting the RFID information read from the pathological tissue slides along with archiving and storage management information regarding the archiving and storage operations into the pathology management system. That is, after diagnosis, the pathological tissue slides can be archived. First, the slides need to be transferred to the archives. For example, the diagnosed slides are placed in front of an RFID reader to read the slide information and the names of the transferring physician and receiving technician, among other archiving management information, are entered into the pathology management system to complete the slide transfer. Figure 20 As shown. Here, Figure 20 The illustration shows a schematic diagram of automatic batch reading of RFID information during the transfer of glass slides to the archives according to an embodiment of this application.
[0080] In addition, for completed paraffin blocks, they can be placed in front of an RFID reader to read the slide information and enter archiving management information such as the names of the handover technician and the receiving technician into the pathology management system, thus completing the handover of the paraffin blocks. Figure 21 As shown. Here, Figure 21 The illustration shows a schematic diagram of the automatic batch reading of RFID information during the transfer of wax blocks to the archives according to an embodiment of this application.
[0081] Then, the archived slides are stored. Specifically, the entire box of slides or paraffin blocks is placed into a dedicated slide box or cabinet with RFID information reading function. The quantity, placement location, and other storage management information related to the storage operation are read and recorded in the pathology management system. This information is then compared with the read RFID information of the slides or paraffin blocks to create a list of unarchived paraffin blocks or slides, such as... Figure 22 and Figure 23 As shown. Here, Figure 22 The illustration shows a schematic diagram of the automatic identification and storage of RFID information for the archiving location of glass slides according to an embodiment of this application. Figure 23 The illustration shows a schematic diagram of the automatic identification and saving of RFID information for the archiving location of wax blocks according to an embodiment of this application.
[0082] In addition, after archiving, there may be situations where archived slides or wax blocks are borrowed. In this case, it is necessary to obtain the borrowing information, such as the name of the receiving technician, and complete the handover of the borrowed slides or wax blocks.
[0083] Meanwhile, for borrowed or returned slides or paraffin blocks, they are placed in a dedicated slide box or cabinet with RFID information reading function. The quantity and location are read and recorded in the pathology management system. The system also records the time, quantity, and borrowing personnel of the borrowed or returned slides or paraffin blocks. Figure 24 As shown. Here, Figure 24 The illustration shows a schematic diagram of the traceability information for the borrowing and handover of wax blocks / slices according to an embodiment of this application.
[0084] Therefore, in the RFID-based pathology whole-process management method according to the embodiments of this application, after the archiving operation of the pathological tissue slides, it further includes: reading the RFID information of the archived slides or paraffin blocks that need to be borrowed, and inputting them together with the borrowing management information regarding the borrowing operation into the pathology management system.
[0085] Exemplary System
[0086] Figure 25The illustration shows a schematic block diagram of a pathology management system for RFID-based pathology process management according to an embodiment of this application.
[0087] like Figure 25 As shown, the pathology management system 200 according to an embodiment of this application is used for RFID-based pathology process management as described above, and includes the following units.
[0088] The embedding management information unit 210 is used to manage the RFID information of the collected pathological tissue and its embedding cassette, as well as embedding management information regarding the embedding process of the pathological tissue. Specifically, the RFID information of the pathological tissue and its embedding cassette may include detailed information about the collection of the pathological tissue, such as the number and size of the pathological tissue pieces within the embedding cassette. Furthermore, the embedding management information regarding the embedding process of the pathological tissue may include embedding information and the embedding operator.
[0089] Furthermore, the embedding management information unit 210 can be further used to manage post-processing management information regarding tissue sampling. Specifically, the post-processing management information includes the serial number of the equipment used for post-processing, the tissue processing procedure, reagent replacement status, actual machine temperature, personnel involved in tissue sampling handover, and tissue processing operators.
[0090] Furthermore, the embedding management information unit 210 can be further used to verify the pathological tissue after sampling and processing with the pathological tissue after embedding.
[0091] The slide management information unit 220 is used to manage RFID information read from the embedded pathological tissue and generate new RFID information on the carrier slide, as well as slide management information and paraffin block management information regarding the slide, staining, and mounting operations. Specifically, the RFID information read from the embedded pathological tissue can be RFID information read from the embedding cassette using an RFID reader, such as the number and size of tissue blocks within the embedding cassette. Furthermore, the slide management information may include, for example, information about the slides already slided and the slide operator. In addition, the mounting management information may include information about stained mounted slides, the staining process of the staining machine, reagent replacement status, room temperature, and the operator.
[0092] Furthermore, the embedding management information unit 210 can be further used to manage post-slicing management information. For example, the post-slicing management information may include RFID information of the slides automatically read by the slide warmer, as well as slide warming temperature, slide retrieval completion, warming temperature and time, and the operator responsible for retrieval.
[0093] The personnel management information unit 230 is used to manage personnel information related to the slides of the pathological tissue, such as the names of the technicians reviewing the slides, the receiving doctors, and patient information. Furthermore, the personnel management information unit 230 can verify the number of slides taken from the patient corresponding to each slide against the total number of slides reviewed to prevent missed slides.
[0094] The archiving and preservation management unit 240 is used for archiving and preservation management information regarding the archiving and preservation operations of the pathological tissue slides and paraffin blocks. For example, the archiving and preservation management information includes RFID information read from the slides after diagnosis, archiving management information such as the names of the handing-over physician and receiving technician, and preservation management information such as the number of preserved slides or paraffin blocks and their placement location.
[0095] Furthermore, the archiving and storage management unit 240 can be further used to manage the borrowing management information regarding the archived and stored slices. For example, the borrowing information includes the borrowing or returning of slices and wax blocks, the time and quantity of the borrowed slices or wax blocks, and the borrowing personnel.
[0096] The basic principles of this application have been described above with reference to specific embodiments. However, it should be noted that the advantages, benefits, and effects mentioned in this application are merely examples and not limitations, and should not be considered as essential features of each embodiment of this application. Furthermore, the specific details disclosed above are for illustrative and facilitative purposes only, and are not limitations. These details do not limit the application to the necessity of employing the aforementioned specific details for implementation.
[0097] The block diagrams of devices, apparatuses, devices, and systems involved in this application are merely illustrative examples and are not intended to require or imply that they must be connected, arranged, or configured in the manner shown in the block diagrams. As those skilled in the art will recognize, these devices, apparatuses, devices, and systems can be connected, arranged, and configured in any manner. Words such as “comprising,” “including,” “having,” etc., are open-ended terms meaning “including but not limited to,” and are used interchangeably with them. The terms “or” and “and” as used herein refer to the terms “and / or,” and are used interchangeably with them unless the context clearly indicates otherwise. The term “such as” as used herein refers to the phrase “such as but not limited to,” and is used interchangeably with it.
[0098] It should also be noted that in the apparatus, equipment, and methods of this application, the components or steps can be disassembled and / or recombined. These disassemblies and / or recombinations should be considered as equivalent solutions of this application.
[0099] The above description of the disclosed aspects is provided to enable any person skilled in the art to make or use this application. Various modifications to these aspects will be readily apparent to those skilled in the art, and the general principles defined herein can be applied to other aspects without departing from the scope of this application. Therefore, this application is not intended to be limited to the aspects shown herein, but rather to be accorded the widest scope consistent with the principles and novel features disclosed herein.
[0100] The above description has been given for purposes of illustration and description. Furthermore, this description is not intended to limit the embodiments of this application to the forms disclosed herein. Although numerous exemplary aspects and embodiments have been discussed above, those skilled in the art will recognize certain variations, modifications, alterations, additions, and sub-combinations thereof.
Claims
1. A method for managing the entire pathological process based on RFID, characterized in that, include: The pathological tissue is sampled and processed, and its RFID information is generated on the embedding cassette. The pathological tissue and the embedding cassette are then embedded. The RFID information and the embedding management information regarding the embedding process are then input into the pathology management system. The embedded pathological tissue is sectioned, stained, and mounted to obtain sections of the pathological tissue and its RFID information is generated. The RFID information read from the embedded pathological tissue, together with the section management information and paraffin block management information regarding the sectioning, staining, and mounting operations, is entered into the pathology management system. Identify personnel information associated with the pathological tissue slices and input the RFID information read from the pathological tissue slices along with the personnel information into the pathology management system; as well as The pathological tissue sections and paraffin blocks are archived and preserved, and the RFID information read from the pathological tissue sections, together with the archive preservation management information regarding the archiving and preservation operations, is entered into the pathology management system. The procedure after sampling pathological tissue further includes: post-sampling processing of the sampled pathological tissue, wherein the post-sampling processing includes dehydration of the pathological tissue. After embedding the pathological tissue and the embedding cassette, the process further includes: confirming whether the post-processed pathological tissue is completely consistent with the embedded pathological tissue. Specifically, firstly, RFID information of post-processed pathological tissue and embedded pathological tissue are obtained. A first text feature vector and a second text feature vector are obtained using a CLIP model text encoder. The difference between the first and second text feature vectors is calculated, i.e., the difference is made between the feature values at each position of the vectors, to obtain a differential text feature vector. Next, images of the post-processed and embedded pathological tissues are acquired. A first image feature vector and a second image feature vector are obtained using a CLIP model image encoder. The difference between the first and second image feature vectors is calculated to obtain a differential image feature vector. Then, the differential text feature vector (including row vectors) is transposed and multiplied with the differential image feature vector (including row vectors) to obtain an association feature matrix as a classification feature matrix. Finally, the classification feature matrix is passed through a classifier, including a softmax-based classifier, to obtain a classification result indicating whether the post-processed pathological tissue and the embedded pathological tissue are completely identical.
2. The RFID-based pathology process management method according to claim 1, wherein, Post-sampling processing of pathological tissues includes: The RFID information of the embedding cassette containing the pathological tissue is read and verified using equipment used for post-sampling processing.
3. The RFID-based pathological process management method according to claim 1, wherein, Post-sampling processing of pathological tissues includes: The post-sampling management information related to the post-sampling processing is entered into the pathology management system.
4. The RFID-based pathological process management method according to claim 1, wherein, Sectioning of embedded pathological tissue includes: The pathological tissue is subjected to post-section processing, and the post-section processing management information is input into the pathology management system. The post-section processing includes at least one of the following: slide spreading, baking, and automatic wax sealing.
5. The RFID-based pathological process management method according to claim 1, wherein, After staining and mounting the sectioned pathological tissue, the following further steps are taken: To determine whether the pathological tissue of the slide is completely consistent with the pathological tissue after staining and mounting.
6. The RFID-based pathology process management method according to claim 1, wherein, After archiving and preserving the slides and paraffin blocks of the pathological tissue, the process further includes: The RFID information of the archived slides or paraffin blocks that need to be borrowed is read and entered into the pathology management system along with the borrowing management information regarding the borrowing operation.