A blood sampling instrument integrating biomarker detection and physiological signal monitoring

Abstract

The embodiment of the application provides a blood sampling instrument integrating biomarker detection and physiological signal monitoring, and relates to the technical field of medical equipment. The blood sampling instrument comprises a controller, a detection and analysis tool, and a containing space for containing a sampled finger of a sampled object. The controller is connected with a photoelectric sensor in the detection and analysis tool. The containing space comprises a pressurizing component and a blood sampling component connected with the controller. The detection and analysis tool is further connected with the blood sampling component. The controller drives the pressurizing component to gradually apply pressure to the sampled finger, and receives a photoelectric pulse wave signal collected from the sampled finger by the photoelectric sensor. If it is determined that the photoelectric pulse wave signal reaches a preset state, the pressurizing component is driven to maintain the current pressure, and the blood sampling component is driven to collect blood of the sampled object from the sampled finger. The detection and analysis tool analyzes the components of the collected blood. The blood sampling instrument provided by the embodiment of the application not only can relieve the tension or anxiety of the sampled object, but also is convenient to carry.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical equipment, in particular, the present application relates to a blood sampling instrument integrating biomarker detection and physiological signal monitoring. BACKGROUND

[0002] In the aspects of pathological study and disease diagnosis, blood detection plays a very important role. Therefore, how to obtain blood samples for detection has become a research direction.

[0003] At present, the blood taking methods in clinic include manual venous blood sampling method and manual fingertip blood sampling method. Among them, the manual venous blood sampling method needs professional medical staff to receive a large amount of training before operation, and the success rate of obtaining blood samples depends on whether the vein of the blood sampling person is easy to be positioned and the blood drawing skill of the medical staff. Although the manual fingertip blood sampling method reduces the requirement for medical staff, it still needs to be operated by trained professionals. Moreover, no matter which blood taking method is used, the blood taking needle with a sharp end and blood are directly exposed to the blood sampling person, which causes the blood sampling person to feel nervous and anxious.

[0004] Further, since the above two blood sampling methods belong to manual methods, they need to be operated by professionals, and are not suitable for blood sampling in the scene without professionals. In order to solve this problem, an automatic blood taking scheme appears in the related technology. For example, an automatic capillary blood taking device disclosed in patents US9033898B2 and US8827971B2, the blood taking position of the device is limited to the upper arm, and the device also needs to be inserted into the arm of the blood sampling person by manual operation, that is, the real automatic blood taking is not realized. For example, a venous blood taking robot disclosed in patent CN106580344B, the robot includes various structures so that the size is large, and the movement is not variable, which is difficult to apply to the scene of real-time blood sampling.

[0005] In recent years, with the progress of point of care testing (POCT, point of care testing) diagnosis technology and the decentralization of medical care has become a trend, how to automatically, simply, safely and standardize blood sample collection at any time under this trend has become a technical problem to be solved urgently. SUMMARY

[0006] The purpose of the embodiment of the present application is to provide a blood sampling instrument integrating biomarker detection and physiological signal monitoring, to solve one of the above technical problems. In order to achieve the purpose, the present application shows the blood sampling instrument through the following contents.

[0007] The embodiment of the present application provides a blood sampling instrument integrating biomarker detection and physiological signal monitoring, comprising: a controller, a detection and analysis tool, and a containing space for containing a sampling finger of a sampling object; the controller is connected with a photoelectric sensor in the detection and analysis tool; the containing space comprises a pressurizing component and a blood sampling component connected with the controller; the detection and analysis tool is further connected with the blood sampling component.

[0008] The controller is used for driving the pressurizing component to gradually apply pressure to the sampling finger, and receiving a photoelectric pulse wave signal collected from the sampling finger by the photoelectric sensor; if it is determined that the photoelectric pulse wave signal in a preset time reaches a preset state, the pressurizing component is driven to maintain the current pressure, and the blood sampling component is driven to collect blood of the sampling object from the sampling finger.

[0009] The detection and analysis tool is used for receiving the collected blood from the blood sampling component and performing component analysis.

[0010] Optionally, the containing space further comprises an operation table and an environment collection sensor connected with the controller; the operation table is horizontally placed in the containing space, and the operation table comprises a through hole; the environment collection sensor is located at a first preset position of the operation table.

[0011] The environment collection sensor is used for collecting real-time environment data in the containing space and sending the real-time environment data to the controller; the real-time environment data comprises any one of the following: real-time image, real-time light intensity data and real-time electrostatic data.

[0012] The controller drives the pressurizing component to gradually apply pressure to the sampling finger, comprising:

[0013] If it is determined that the change degree of the real-time environment data meets a preset condition, it is determined that the sampling finger enters the containing space, and a first real-time distance between the environment collection sensor and the sampling finger is obtained; a second real-time distance between the end of the sampling finger and the through hole is determined according to the distance between the environment collection sensor and the through hole and the first real-time distance; if it is determined that the second real-time distance is reduced to a preset distance, the pressurizing component is driven to gradually apply pressure to the end of the sampling finger.

[0014] Optionally, the blood sampling instrument further comprises a display screen connected with the controller.

[0015] The display screen is used for displaying coordinates of the through hole in a preset coordinate system and coordinates of the end of the sampling finger in the preset coordinate system.

[0016] Optionally, the containing space further comprises a movable sterilizer.

[0017] The controller is used for adjusting the relative position relationship between the sterilizer and the sampling finger according to the real-time position of the sampling finger, and instructing the sterilizer to sterilize.

[0018] Optionally, the blood collection component includes a microneedle and a vacuum blood collection chamber; the microneedle is located at the lower outlet of the through-hole, and the tip of the finger being collected, which is subjected to the current pressure, covers the upper inlet of the through-hole.

[0019] The process of the controller driving the blood collection component to collect blood from the skin at the end of the subject includes: driving the microneedle to enter the through hole from the lower entrance of the through hole and performing a needle puncture operation on the skin at the end, and collecting blood from the puncture point through the vacuum blood collection chamber.

[0020] Optionally, the blood collection component also includes a microfluidic channel, the outlet of which is located at the entrance of the vacuum blood collection chamber, and the entrance of which is located at the outlet below the through hole.

[0021] Microflow channels are used to receive blood flowing from the puncture site on the finger being sampled.

[0022] If the valve of the vacuum blood collection chamber is closed, blood flows through the microfluidic channel to the valve of the vacuum blood collection chamber and reacts with the valve to make the valve disappear; the valve is a lipid-soluble film.

[0023] Optionally, determining that the photoelectric pulse wave signal reaches a preset state within a preset time period includes:

[0024] The system receives several photoelectric pulse wave signals collected within a preset time period and performs filtering processing to obtain several filtered photoelectric pulse wave signals. For each filtered photoelectric pulse wave signal, if the filtered photoelectric pulse wave signal contains a main wave, a tidal wave, a diphtheria peak, and a diphtheria trough, then the filtered photoelectric pulse wave signal is determined to have reached a preset state. If several filtered photoelectric pulse wave signals reach the preset state respectively, then the photoelectric pulse wave signals within the preset time period are determined to have reached the preset state.

[0025] Optionally, the blood collection device also includes a first storage area for storing used blood collection components; and a second storage area for storing multiple spare blood collection components; the multiple spare blood collection components are stored in a vertically stacked manner; the blood collection device also includes a horizontal booster and a vertical booster for updating blood collection components; the blood collection component currently performing the blood collection operation is located at a second preset position on the operating table;

[0026] The controller is also configured to, after the analysis operation is completed, drive the lateral booster to push the current blood collection component into the first storage area; and drive the longitudinal booster to push the uppermost blood collection component among a plurality of spare blood collection components into the second preset position.

[0027] The beneficial effects of the technical solutions provided in this application are:

[0028] The embodiment of the present application provides a blood sampling instrument integrating biomarker detection and physiological signal monitoring, comprising a controller, a photoelectric sensor, an analysis tool, and a containing space for containing a sampled finger of a sampled object. The working process of the blood sampling instrument is as follows: the controller drives a pressing component to gradually apply pressure to the sampled finger, and receives a photoelectric pulse wave signal collected from the sampled finger by the photoelectric sensor; if it is determined that the photoelectric pulse wave signal reaches a preset state, the pressing component is driven to maintain the current pressure, and a blood sampling component is driven to collect blood of the sampled object from the sampled finger; finally, the analysis tool receives the collected blood from the blood sampling component, and performs blood component analysis. On the one hand, the size of each module is small, so that the blood sampling instrument containing these modules is also small, thereby improving the portability of the blood sampling instrument, and facilitating blood detection of the sampled object at any time and anywhere. On the other hand, by arranging the containing space in the blood sampling instrument, blood collection of the sampled finger is realized, so as to avoid directly presenting the blood sampling process to the sampled object, thereby causing nervous or anxious emotions of the sampled object. Therefore, the blood sampling instrument provided by the embodiment of the present application not only can alleviate the nervous or anxious emotions of the sampled object, but also can carry out blood sampling operation at any time and anywhere due to the small size.

[0029] The blood sampling instrument provided by the embodiment of the present application integrates physiological signal detection, blood sampling and analysis functions, that is, the detected physiological signal (such as a photoelectric pulse wave signal) is integrated into the biomarker (such as blood) detection process, and the analysis tool is used for component analysis of the collected biomarker. That is, through the blood sampling instrument, the purpose of point-of-care testing for blood detection process is realized. BRIEF DESCRIPTION OF DRAWINGS

[0030] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments of the present application will be briefly introduced.

[0031] Figure 1a An architecture schematic diagram of the blood sampling instrument integrating biomarker detection and physiological signal monitoring provided by the embodiment of the present application;

[0032] Figure 1b An architecture schematic diagram of another blood sampling instrument integrating biomarker detection and physiological signal monitoring provided by the embodiment of the present application;

[0033] Figure 2 Structure schematic diagrams of various pressing components provided by the embodiment of the present application;

[0034] Figure 3 A flowchart of testing real-time distance of an infrared distance measuring sensor provided by the embodiment of the present application;

[0035] Figure 4An application scenario schematic diagram of a horizontal coordinate system provided for an embodiment of the present application is shown in FIG. 1.

[0036] Figure 5a A structure schematic diagram of a disposable blood sampling chip provided for an embodiment of the present application is shown in FIG. 2.

[0037] Figure 5b A structure schematic diagram of a blood sampling microneedle provided for an embodiment of the present application is shown in FIG. 3.

[0038] Figure 5c An appearance schematic diagram of a disposable blood sampling chip provided for an embodiment of the present application is shown in FIG. 4.

[0039] Figure 6a A waveform schematic diagram of a complete PPG signal provided for an embodiment of the present application is shown in FIG. 5.

[0040] Figure 6b A waveform schematic diagram of a plurality of continuous PPG signals provided for an embodiment of the present application is shown in FIG. 6.

[0041] Figure 7a A spring device schematic diagram of a booster provided for an embodiment of the present application is shown in FIG. 7.

[0042] Figure 7b A connection schematic diagram of a booster and a disposable blood sampling chip provided for an embodiment of the present application is shown in FIG. 8.

[0043] Figure 7c A motion scenario schematic diagram of a booster provided for an embodiment of the present application is shown in FIG. 9.

[0044] Figure 8 A multifunctional fingertip automatic blood sampling instrument provided for an embodiment of the present application is shown in FIG. 10.

[0045] Figure 9a A work flow schematic diagram of a multifunctional fingertip automatic blood sampling instrument provided for an embodiment of the present application is shown in FIG. 11.

[0046] Figure 9b A structure schematic diagram of an index finger provided for an embodiment of the present application is shown in FIG. 12. DETAILED DESCRIPTION

[0047] Embodiments of the present application are described below with reference to the accompanying drawings. It should be understood that the embodiments described below with reference to the accompanying drawings are exemplary descriptions of the technical solutions of the embodiments of the present application, and do not limit the technical solutions of the embodiments of the present application.

[0048] Those skilled in the art can understand that the singular forms "a," "an," and "the" used herein include plural forms unless otherwise stated. It should be further understood that the terms "include" and "contain" used in the embodiments of the present application mean that the corresponding features can be implemented as the presented features, information, data, steps, operations, elements and / or components, but do not exclude other features, information, data, steps, operations, elements, components and / or their combinations supported by the present technology. It should be understood that when we say that an element is "connected" or "coupled" to another element, the element can be directly connected or coupled to the other element, or it can mean that the element and the other element are connected through an intermediate element. In addition, "connected" or "coupled" used herein can include wireless connection or wireless coupling. The term "and / or" used herein means that at least one of the items defined by the term, for example, "A and / or B" means that "A" is implemented, or "A" is implemented, or "A and B" are implemented.

[0049] For the purpose, technical solutions and advantages of the present application to be clearer, the embodiments of the present application will be described in further detail below with reference to the drawings.

[0050] Point of care testing (POCT) diagnostic technology: a detection method that uses portable analysis instruments and supporting reagents to quickly obtain detection results at the sampling site.

[0051] The photoelectric pulse wave signal, i.e., the PPG signal, is measured by the photoelectric plethysmogram technology. The photoelectric plethysmogram technology (PPG) is a relatively simple and inexpensive technology that is widely used in medicine to measure heart rate, blood pressure and blood oxygen saturation; the technology is based on the illumination of the skin and the measurement of changes in its light absorption. The device for collecting the PPG signal includes at least one light-emitting diode and one photodetector (photodiode), and the working principle of the device is that the light-emitting diode (LED) illuminates the skin, and the photodetector measures the intensity of the light passing through or reflected from the skin.

[0052] The technical solutions of the embodiments of the present application and the technical effects produced by the technical solutions of the present application will be described below by describing several exemplary embodiments. It should be pointed out that the following embodiments can be mutually referenced, borrowed or combined, and the same terms, similar features and similar implementation steps in different embodiments will not be described repeatedly.

[0053] Figure 1aA structure schematic diagram of a blood sampling instrument 10 integrating biomarker detection and physiological signal monitoring is shown. The blood sampling instrument 10 comprises a controller 110, a detection and analysis tool 121, and a receiving space 120 for receiving a sampling finger of a sampling subject; the controller 110 is connected with a photoelectric sensor in the detection and analysis tool 121; the receiving space 120 comprises a pressurizing component 122 and a blood sampling component 123 connected with the controller 110; and the detection and analysis tool 121 is further connected with the blood sampling component 123.

[0054] Optionally, the whole internal space of the blood sampling instrument 10 can be regarded as the receiving space 120; a hollow structure similar to the outer contour of the finger can also be created as the receiving space 120, and the hollow area inside the hollow structure can be regarded as the receiving space 120. The receiving space 120 is in the visual blind area of the sampling subject.

[0055] The controller 110 is configured to drive the pressurizing component 122 to gradually apply pressure to the sampling finger, and receive photoelectric pulse wave signals collected by the photoelectric sensor from the sampling finger; if it is determined that the photoelectric pulse wave signals reach a preset state, the controller 110 drives the pressurizing component 122 to maintain the current pressure, and drives the blood sampling component 123 to collect blood of the sampling subject from the sampling finger.

[0056] The detection and analysis tool 121 is configured to receive the collected blood from the blood sampling component 123, and perform component analysis.

[0057] The blood sampling instrument 10 provided by the embodiments of the present application has relatively small sizes of various modules, so that the blood sampling instrument 10 receiving the modules is also relatively small, that is, the blood sampling instrument 10 has the advantage of portability, and the blood sampling operation can be conveniently performed on the sampling subject at any time and anywhere. By arranging the receiving space 120 in the blood sampling instrument 10, the blood collection of the sampling finger is performed, so as to avoid directly presenting the blood sampling process to the sampling subject, and causing the sampling subject to be nervous or anxious. Therefore, the blood sampling instrument 10 provided by the embodiments of the present application not only can alleviate the nervous or anxious emotion of the sampling subject, but also can perform the blood sampling operation at any time and anywhere due to the relatively small size.

[0058] On one hand, when the sampling finger is inserted into the receiving space 120, the end of the sampling finger is firstly inserted into the receiving space 120, and causes the real-time environmental data collected to change. On the other hand, the blood sampling instrument 10 shown in the embodiments of the present application generally performs needle puncture on the skin part of the end of the sampling finger, and collects blood. If the end of the sampling finger is not placed in the correct position, the pressure is applied and the subsequent blood sampling operation is performed, which is relatively dangerous. In order to avoid this problem, the embodiments of the present application further provide an embodiment.

[0059] In an optional embodiment, the accommodation space 120 further comprises an operation table 124 and an environment collection sensor 125 connected to the controller 110, as shown in the figure; the operation table 124 is horizontally placed in the accommodation space 120, and the operation table 124 comprises a through hole; the environment collection sensor 125 is located at a first preset position of the operation table 124. Figure 1b

[0060] Optionally, the pressurizing component 122 is perpendicular to the operation table 124 and is directly above the through hole; the first preset position can be understood as a fixed position of the environment collection sensor 125 in the pressurizing component 122.

[0061] The environment collection sensor 125 is configured to collect real-time environment data in the accommodation space 120 and send the real-time environment data to the controller 110; the real-time environment data comprises any one of the following: real-time image, real-time light intensity data and real-time electrostatic data.

[0062] During the process in which the controller 110 drives the pressurizing component 122 to gradually apply pressure to the sampled finger, the following steps Sa1-Sa3 are performed.

[0063] Sa1, if it is determined that the change degree of the real-time environment data meets a preset condition, it is determined that the sampled finger enters the accommodation space 120, and a first real-time distance between the environment collection sensor 125 and the sampled finger is obtained.

[0064] Sa2, according to the distance between the environment collection sensor 125 and the through hole and the first real-time distance, a second real-time distance between the end of the sampled finger and the through hole is determined.

[0065] Sa3, if it is determined that the second real-time distance decreases to a preset distance, the pressurizing component 122 is driven to gradually apply pressure to the end of the sampled finger.

[0066] Optionally, if the environment collection sensor 125 is a camera, the real-time environment data is real-time images collected by the camera. Specifically, the camera can collect real-time images at a fixed position according to a preset frequency; when a finger is deep into the accommodation space 120, the finger is contained in the real-time image collected at the time when the finger is deep into the accommodation space 120. That is, compared with the real-time image collected before this time, the real-time image collected at this time contains more “finger”, which can also be understood as the change degree of the real-time image data containing the “finger” meets the preset condition.

[0067] ​Optionally, if the environment collection sensor 125 is a light ranging sensor, the real-time environment data is light intensity collected by a photoelectric sensor. The photoelectric sensor can be infrared light or other types of light. When there is no finger in the accommodation space 120, the light intensity data collected by the light ranging sensor comes from the inner surface of the accommodation space 120; when a finger is inserted into the accommodation space 120, the light intensity data collected by the light ranging sensor comes partly from the surface of the finger, which is obviously different from the light intensity data collected from the inner surface of the accommodation space 120. When the real-time light intensity data is greater than a first preset threshold, it can be determined that the change degree of the real-time light intensity data meets the preset condition.

[0068] Optionally, if the environment collection sensor 125 is an electrostatic field detection coil, the real-time environment data is electrostatic data collected by the electrostatic field detection coil. When a finger is inserted into the accommodation space 120, the electrostatic data collected by the electrostatic field detection coil in the area where the finger is located is different from the different electrostatic data collected in the area without the finger. When the real-time electrostatic data is greater than a second preset threshold, it can be determined that the change degree of the real-time electrostatic data meets the preset condition.

[0069] In addition, the related art also provides a scheme for calculating the distance between the environment collection sensor 125 and the finger according to the image data, the light intensity data or the electrostatic data, which is not described here for the sake of simplicity.

[0070] Optionally, the preset distance can be zero. The second real-time distance being zero can be understood as the end of the collected finger being located on the operation table 124. The gradually applying pressure can be understood as gradually increasing the applied pressure in the process of applying pressure to the end of the collected finger.

[0071] In order to more clearly understand the process of the pressure applying component 122 applying pressure to the end of the collected finger, the present embodiment also provides a structural schematic diagram of the pressure applying component 122 and a structural schematic diagram of the operation table 124. As shown in Figure 2 The inner side of the circular arc structure of the pressure applying component 122 can be in contact with the end of the collected finger. Since the end of the collected finger is located on the operation table 124, the controller 110 drives the pressure applying component 122 to move towards the operation table 124, thereby forming extrusion to the end of the collected finger, that is, forming pressure.

[0072] To adapt to the needs of the scenario, the receiving space 120 is designed to be opaque so that the process within the receiving space 120 is in the blind spot of the subject. When the subject inserts their finger into the receiving space 120, both the tip of the finger and the operating table 124 are within the subject's blind spot. Correctly placing the tip of the finger on the operating table 124 takes time; that is, the current design prolongs the blood collection time. To improve blood collection efficiency, this application also provides an embodiment.

[0073] To better understand the function of the environmental acquisition sensor 125, this embodiment also uses an infrared ranging sensor as an example to demonstrate the working process of the environmental acquisition sensor, specifically as follows: Figure 3 As shown. In Figure 3 In the diagram, the horizontal axis represents distance, and the vertical axis represents the voltage value corresponding to the light intensity information. Since white light reflects 90% of the light intensity information in the collected data, white light is used as a reference. Figure 3 The solid line in the diagram represents the distance between the two sets of light intensity data. This process also collects multiple sets of light intensity data (the photoelectric sensor converts the collected light intensity data into an equivalent voltage value and outputs it), as well as corresponding first real-time data. To observe the relationship between the two sets of data, this embodiment also creates a relationship curve for the two sets of data. The curve shows that the larger the light intensity data, the smaller the first real-time distance; conversely, the smaller the light intensity data, the smaller the first real-time distance.

[0074] In an optional embodiment, the blood collection device 10 further includes a display screen 140 connected to the controller 110, specifically as follows: Figure 1b As shown.

[0075] The display screen is used to display the coordinates of the through hole in a preset coordinate system, and the coordinates of the end of the finger being sampled in the preset coordinate system.

[0076] Optionally, the controller 110 can create a preset coordinate system on a horizontal plane with the through-hole as the origin. The direction from the through-hole to the entrance of the receiving space 120 can be used as the vertical axis of the preset coordinate system. The coordinates of the fingertip in the horizontal coordinate system are determined based on the distance between the fingertip and the through-hole. This position adjustment information may include the coordinates of the fingertip in the horizontal coordinate system.

[0077] Because the coordinate system has strong positional indication, the recipient can quickly determine the adjustment direction of the finger under the guidance of the preset coordinate system, and promptly adjust the end of the finger to the through hole, thereby improving blood collection efficiency.

[0078] To better understand the technical effects of this implementation, this application also provides a schematic diagram of a blood collection device with a display screen, as shown below.Figure 4 As shown, when the donor finger extends into the accommodation space, a preset coordinate system is displayed on the display screen on the surface of the blood sampling instrument, and the coordinates of the end of the donor finger and the operation table are displayed on the preset coordinate system. Among them, at Figure 4 As shown, at the current time, the end of the donor finger is at the origin, i.e., has been located at the operation table.

[0079] Generally, before performing the blood sampling operation, the donor site and the instrument are usually disinfected to avoid the needle puncture site being infected by the environment. In order to achieve disinfection before blood sampling, an embodiment of the present application also provides an embodiment.

[0080] In an alternative embodiment, the blood sampling instrument 10 further comprises a movable disinfecting device 150, as shown in detail. Figure 1b

[0081] The controller 110 is configured to adjust the relative position relationship between the disinfecting device 150 and the donor finger according to the real-time position of the donor finger, and instruct the disinfecting device 150 to disinfect.

[0082] Among them, the disinfecting device 150 comprises a disinfectant storage component and a spray head for spraying disinfectant. The number of spray heads can be multiple.

[0083] Optionally, the controller 110 determines to perform the disinfection operation if the degree of change of the real-time environmental data meets the preset condition. Further, after the controller 110 determines the real-time position of the end of the donor finger, the controller 110 determines the spraying angle of the spray head according to the real-time position, and sends a disinfection instruction carrying the spraying angle to the disinfecting device 150. The disinfecting device 150 adjusts the rotation direction of the spray head of the disinfecting device 150 according to the spraying angle, so that the spray head is aligned with the end of the donor finger. After adjusting the rotation direction of the spray head, the disinfectant is sprayed.

[0084] Optionally, the disinfection operation determined by the controller 110 further comprises disinfection of the accommodation space 120 and the disinfection table.

[0085] An embodiment of the present application is also provided to illustrate the blood sampling component 123 performing the blood sampling process.

[0086] In an alternative embodiment, the blood sampling component 123 comprises a microneedle and a vacuum blood sampling cavity; the microneedle is located at the lower outlet of the through hole, and the end of the donor finger subjected to the current pressure covers the upper inlet of the through hole.

[0087] Among them, the process of the controller 110 driving the blood sampling component 123 to collect the blood of the donor from the skin site of the end includes: driving the microneedle to enter the through hole from the lower inlet of the through hole, and performing the needle puncture operation on the skin site of the end, and collecting the blood of the donor from the needle puncture point through the vacuum blood sampling cavity.​

[0088] Wherein, the through hole is a hollow part on the operation platform 124. On one hand, the skin part of the finger of the blood donor contacts with the operation platform 124, and then enters the through hole under the extrusion of the pressing part 122, forming a cover for the upper entrance of the through hole; on the other hand, the microneedle enters the through hole from the lower entrance of the through hole to a preset depth under the drive of the controller 110, which can ensure that the microneedle can pierce the blood vessel of the skin part to form a wound. In order to ensure the safety of the blood collection process, the microneedle and the vacuum blood collection cavity are independently arranged in the embodiment of the application. Therefore, the controller 110 not only drives the microneedle to pierce the skin part, but also drives the microneedle to exit the skin part after piercing.

[0089] Wherein, the vacuum blood collection cavity further comprises a valve, which is in a closed state before use, so as to maintain a vacuum state and provide a safe and sterile storage environment for the collected blood.

[0090] Optionally, the valve is connected with the controller 110; after the controller 110 drives the microneedle to exit, the valve can be driven to open, so that the vacuum blood collection cavity starts to collect blood.

[0091] Optionally, the valve can also be a lipid-soluble film. Wherein, the blood collection part 123 further comprises a micro-flow channel, the outlet of the micro-flow channel is located at the entrance of the vacuum blood collection cavity, and the inlet of the micro-flow channel is located at the lower outlet of the through hole. The micro-flow channel is used to receive the blood flowing out of the pierced point of the finger of the blood donor; wherein, if the valve of the vacuum blood collection cavity is in a closed state, the blood flows to the valve through the micro-flow channel and dissolves the valve, so that the valve disappears. After the valve disappears, the vacuum blood collection cavity starts to collect blood.

[0092] Wherein, when the vacuum blood collection cavity starts to collect blood, the blood can be rapidly introduced into the vacuum blood collection cavity by the pressure generated by the vacuum.

[0093] Since the lipid-soluble film dissolves when it meets the blood, the valve will disappear after the dissolution reaction ends, that is, the lipid-soluble film achieves the purpose of opening the valve by the action of the blood.

[0094] In order to more clearly understand the effect of the blood collection part 123, the embodiment further provides an example of a disposable blood collection chip, as shown in Figure 5a Wherein, the disposable blood collection chip can be understood as the blood collection part 123. In this example, the blood collection micro-channel corresponds to the micro-flow channel in the above embodiment; the blood collection needle corresponds to the microneedle in the above embodiment; and the vacuum blood collection driving cavity corresponds to the vacuum blood collection cavity in the above embodiment.

[0095] In this example, the blood collection microneedle of the disposable blood collection chip can be Figure 5bAny one of the structures shown. Among them, from left to right

[0096] In this example, the vacuum blood sampling driving cavity includes a microfluidic structure to control the speed of blood collection, specifically as shown in Figure 5c The "circular" structure in the vacuum blood sampling driving cavity shown. In addition, Figure 5c Also shows a movement process of the microneedle, such as can be lifted.

[0097] Optionally, the detection and analysis tool 121 can not only detect the photoelectric pulse wave signal through the photoelectric sensor, but also analyze the components of the blood collected by the blood sampling component 123.

[0098] Specifically, the component analysis includes: single cell imaging and analysis; blood glucose and blood lipid detection; biomarker detection, such as marker protein, mRNA.

[0099] Optionally, after obtaining the analysis result, the PPG signal collected by the photoelectric sensor and the analysis result are output together.

[0100] It should be pointed out that the analysis technology adopted by the detection and analysis tool 121 can refer to the introduction of related technologies, and for the sake of description, it will not be described here.

[0101] In order to clearly understand the role of the photoelectric pulse wave signal in the blood sampling process, an embodiment is provided to elaborate in detail.

[0102] In an optional embodiment, the controller 110 determines that the photoelectric pulse wave signal reaches a preset state, including the following steps Sb1-Sb3.

[0103] Sb1, receive a plurality of photoelectric pulse wave signals collected within a preset time, and perform filtering processing to obtain a plurality of filtered photoelectric pulse wave signals.

[0104] Sb2, for each filtered photoelectric pulse wave signal, if the filtered photoelectric pulse wave signal has a main wave, a tidal wave, a double pulse wave peak and a double pulse wave valley, it is determined that the filtered photoelectric pulse wave signal reaches a preset state.

[0105] Specifically, for any filtered photoelectric pulse wave signal (i.e. PPG signal), whether it has characteristic data is confirmed and marked. Among them, the markable characteristic data has main wave, tidal wave, double pulse wave peak and double pulse wave valley. If the marked data has main wave, tidal wave, double pulse wave peak and double pulse wave valley, it means that the collected photoelectric pulse wave signal is normal. It can be understood that if the normal PPG signal is continuously detected from the end of the sampled finger, it means that the sampled finger under the current pressure enters the blood sampling state.

[0106] Sb3, if a plurality of filtered photoelectric pulse wave signals respectively reach a preset state, determining that the photoelectric pulse wave signals in the preset time reach the preset state.

[0107] In order to more clearly understand the technical effects of the embodiment, an example is provided to explain in detail. As shown in the accompanying Figure 6a A complete PPG signal is shown, including systole and diastole, the pulse waveform has A, B, C and D, a total of 4 important feature points, including the ascending branch and the descending branch; wherein A is called the main wave, B is called the tidal wave, C is called the heavy beat wave peak, and D is called the heavy beat wave valley, OA is the main wave ascending branch, OO' is the pulse wave period, and the change of the pulse wave curve reflects the physiological and pathological changes of the human body. As shown in the accompanying Figure 6b A plurality of PPG signals are continuously collected, from 6.5s to 8.5s, a total of two normal PPG signals are collected. Further, the pressure applied by the pressing component 122 is maintained, and the blood sampling operation is started.

[0108] The blood sampling component 123 provided by the embodiment is a disposable product, so after use, the used blood sampling component 123 needs to be replaced, and how to replace the blood sampling component 123 is also a technical problem to be solved. In order to solve this technical problem, an optional embodiment is also provided.

[0109] In an optional embodiment, the blood sampling instrument 10 further comprises a first storage area for storing the used blood sampling component 123; and a second storage area for storing a plurality of spare blood sampling components 123; the plurality of spare blood sampling components 123 are stored in a longitudinal stacking manner; the blood sampling instrument 10 further comprises a booster 160 for updating the blood sampling component 123, the booster 160 comprises a horizontal booster and a vertical booster; the blood sampling component 123 currently performing the blood sampling operation is located at the second preset position of the operation table 124.

[0110] The controller 110 is also used to drive the horizontal booster to push the current blood sampling component 123 into the first storage area after the analysis operation is performed. And drive the vertical booster to push the uppermost blood sampling component 123 in the plurality of spare blood sampling components 123 into the second preset position.

[0111] Specifically, when the blood sampling component 123 is located at the second preset position of the operation table 124, the microneedle of the blood sampling component 123 and the inlet of the vacuum blood sampling cavity are below the outlet of the through hole of the blood sampling table.

[0112] The horizontal booster and the vertical booster comprise a motor, and the controller 110 assists the replacement of the blood sampling component 123 by driving the movement of the motor.

[0113] To more clearly understand the technical effects of the embodiment, the application further provides a booster example. In the example, the longitudinal booster is composed of a telescopic pull rod and a spring pad, as shown in the spring assembly in Figure 7a , and the telescopic pull rod in Figure 7b . Specifically, the B face of the spring pad is connected with the telescopic pull rod, and the A face of the spring pad is provided with a standby disposable blood sampling chip. The transverse booster is composed of a telescopic pull rod. The transverse booster pushes the transverse movement of the used disposable blood sampling chip, as shown in Figure 7b ; when the telescopic pull rod of the longitudinal booster is expanded, the disposable blood sampling chip on the spring pad is pushed.

[0114] In the example, based on the booster examples shown in Figure 7a and Figure 7b , the application further provides a working process of the booster, as shown in Figure 7c . The process includes steps S701-S704.

[0115] S701, start the replacement motor of the disposable blood sampling chip.

[0116] S702, control the horizontal movement of the telescopic rod of the transverse booster to push the used disposable blood sampling chip into the biomedical waste bag, and control the telescopic rod to return to the original position.

[0117] S703, control the vertical movement of the telescopic rod of the longitudinal booster to push the new disposable blood sampling chip into the blood sampling position, and control the telescopic rod to return to the original position.

[0118] S704, replacement is completed.

[0119] To more clearly understand the technical effects of the blood sampling instrument 10, the application further provides an example of a multifunctional fingertip blood sampling instrument, as shown in Figure 8 . In the example, the driving platform device corresponds to the pressing component 122 in the above embodiment; the disposable blood sampling chip corresponds to the blood sampling component 123 in the above embodiment; the automatic disinfection spraying device corresponds to the sterilizer 150 in the above embodiment; and the finger corresponds to the sampled finger in the above embodiment.

[0120] Based on the multifunctional fingertip automatic blood sampling instrument, the application further provides a working process of the multifunctional fingertip blood sampling instrument, as shown in Figure 9a . In the example, the working process includes steps S1001-S1007.

[0121] S1001, receive the start instruction of the user and start the device, and perform device inspection.

[0122] Specifically, the inspection items include: whether the disposable blood collection chip has been replaced; whether each module is powered on normally; whether the disinfectant storage bottle contains sufficient alcohol; and whether sufficient hemostatic patches are prepared if an automatic hemostasis device is available.

[0123] S1002 prompts the user to insert their index finger.

[0124] If all the checks in S1001 have been completed, a prompt message will be displayed on the screen to remind the user to insert their finger into the blood collection device.

[0125] S1003, detecting the fingertip position.

[0126] like Figure 9b The diagram shows the structure of an index finger. The index finger has three joints, which are: the metacarpophalangeal joint, the first joint, and the second joint, starting from the palm towards the fingertip. The point from the second joint to the fingertip is the end of the index finger, and the skin at the end of the index finger is the puncture site for the blood collection device.

[0127] Since the fingertip of the index finger is located at the end of the index finger, it can be used as a representative of the end of the index finger, and detecting the fingertip is essentially detecting the position of the end of the index finger.

[0128] During the detection process, the distance between the fingertip of the index finger and the operating table 124 is calculated, and the above position information is displayed on the screen of the multi-functional fingertip automatic blood collection device to prompt the user to adjust the position of the fingertip of the index finger according to the position information.

[0129] S1004, drive platform descent.

[0130] Specifically, the drive platform descends and contacts the tip of the index finger, attempting to secure the fingertip to the operating table 124. A position sensing sensor determines whether the fingertip is above the through-hole of the operating table 124. If it is determined that the skin at the tip of the index finger is above the through-hole, it can be confirmed that the fingertip has reached the blood collection position.

[0131] S1005, begin blood collection.

[0132] After confirming that the fingertip has reached the blood collection location, the blood collection needle driver drives the microneedle of the disposable blood collection chip to rise so as to pierce the skin of the fingertip. After successfully piercing the fingertip, the microneedle is driven to fall back so that blood can enter the vacuum blood collection chamber of the disposable blood collection chip.

[0133] After the blood draw is completed, a prompt message appears on the screen: "Please remove your finger."

[0134] S1006, for blood analysis.

[0135] The multifunctional fingertip automatic blood taking instrument can also perform the following analysis on the collected blood: cell sorting and counting, biomarker detection, etc.

[0136] S1007, replacing the disposable blood taking chip.

[0137] After blood collection is completed, the disposable blood taking chip is pushed into a biological medical waste bag, and a new disposable blood taking chip is replaced.

[0138] The terms "first", "second", "third", "fourth", "1", "2", etc. (if any) in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and do not necessarily describe a specific order or sequence. It should be understood that the data thus used can be interchanged under appropriate circumstances, so that the embodiments of the present application described herein can be implemented in an order other than that illustrated or described.

[0139] It should be understood that although the flowcharts of the embodiments of the present application indicate various operation steps by arrows, the implementation order of these steps is not limited to the order indicated by the arrows. Unless otherwise specified herein, in some implementation scenarios of the embodiments of the present application, the implementation steps in each flowchart can be executed in other orders as required. In addition, part or all of the steps in each flowchart can include multiple sub-steps or multiple stages based on the actual implementation scenario. Part or all of these sub-steps or stages can be executed at the same time, and each of these sub-steps or stages can also be executed at different times. In scenarios where the execution times are different, the execution order of these sub-steps or stages can be flexibly configured as required, and the embodiments of the present application do not limit this.

[0140] The above is only an optional implementation of some implementation scenarios of the present application. It should be pointed out that for ordinary skilled persons in the technical field, other similar implementation means based on the technical idea of the present application without departing from the technical concept of the present application also belong to the protection scope of the embodiments of the present application.

Claims

1. A blood collection device integrating biomarker detection and physiological signal monitoring, characterized in that, include: The controller, detection and analysis tools, and a space for accommodating the finger being sampled; The accommodating space also includes an operating table, which is placed horizontally within the accommodating space and includes a through-hole. The controller is connected to a photoelectric sensor in the detection and analysis tool. The accommodating space includes a pressurizing component and a blood collection component connected to the controller. The pressurizing component is perpendicular to the operating table and directly above the through-hole. The pressurizing component contacts the tip of the finger being collected and applies pressure to the finger by squeezing the fingertip, so that the fingertip pad covers the upper entrance of the through-hole under pressure. The detection and analysis tool is also connected to the blood collection component. The controller is used to drive the pressurizing component to gradually apply pressure to the finger being sampled, and to receive the photoelectric pulse wave signal collected by the photoelectric sensor from the finger being sampled; if it is determined that the photoelectric pulse wave signal reaches a preset state within a preset time, the controller drives the pressurizing component to maintain the current pressure, and drives the blood collection component to perform a needle puncture operation on the finger being sampled from below the through hole to collect blood from the subject being sampled. The preset state is that a number of filtered photoelectric pulse signals are detected to be normal signals within the preset time, and the normal signals contain a main wave, a tidal wave, a dicrotic peak, and a dicrotic trough. A detection and analysis tool is used to perform component analysis on the blood collected by the blood collection component.

2. The blood collection device according to claim 1, characterized in that, The accommodating space also includes an environmental acquisition sensor connected to the controller; the environmental acquisition sensor is located at a first preset position on the operating panel; wherein... The environmental acquisition sensor is used to collect real-time environmental data in the containment space and send it to the controller; the real-time environmental data includes any one of the following: real-time image, real-time light intensity data, and real-time electrostatic data; The controller drives the pressurizing component to gradually apply pressure to the finger being sampled, including: If the degree of change in the real-time environmental data is determined to meet the preset conditions, then the finger being sampled is determined to enter the receiving space, and the first real-time distance between the environmental acquisition sensor and the finger being sampled is obtained; based on the distance between the environmental acquisition sensor and the through hole and the first real-time distance, the second real-time distance between the tip of the finger being sampled and the through hole is determined; if the second real-time distance is determined to decrease to the preset distance, then the pressurizing component is driven to gradually apply pressure to the tip of the finger being sampled.

3. The blood collection device according to claim 2, characterized in that, The blood collection device also includes a display screen connected to the controller; wherein, The display screen is used to display the coordinates of the through hole in a preset coordinate system, and the coordinates of the end of the finger being sampled in the preset coordinate system.

4. The blood collection device according to claim 2, characterized in that, The containment space also includes a movable sterilizer; wherein... The controller is also used to adjust the relative position of the sterilizer and the finger being sampled according to the real-time position of the finger being sampled, and to instruct the sterilizer to perform sterilization.

5. The blood collection device according to claim 2, characterized in that, The blood collection component includes a microneedle and a vacuum blood collection chamber; the microneedle is located at the lower outlet of the through hole, and the tip of the finger being collected, which is subjected to the current pressure, covers the upper inlet of the through hole; The process by which the controller drives the blood collection component to collect blood from the recipient at the skin site at the distal end includes: The microneedle is driven to enter the through hole from the lower entrance of the through hole, and a needle puncture operation is performed on the skin part at the end, and blood of the subject is collected from the puncture point through the vacuum blood collection chamber.

6. The blood collection device according to claim 5, characterized in that, The blood collection component further includes a microfluidic channel, the outlet of which is located at the inlet of the vacuum blood collection chamber, and the inlet of which is located at the outlet below the through hole; wherein, The microfluidic channel is used to receive blood flowing from the puncture site of the finger being sampled; If the valve of the vacuum blood collection chamber is closed, the blood flows through the microfluidic channel to the valve of the vacuum blood collection chamber and reacts with the valve to make the valve disappear; the valve is a lipid-soluble film.

7. The blood collection device according to claim 1, characterized in that, The determination that the photoelectric pulse wave signal reaches a preset state within a preset time period includes: Receive several photoelectric pulse wave signals collected within the preset time period, and perform filtering processing to obtain several filtered photoelectric pulse wave signals. For each filtered photoelectric pulse wave signal, if the filtered photoelectric pulse wave signal contains a main wave, a tidal wave, a diphtheria peak, and a diphtheria trough, then the filtered photoelectric pulse wave signal is determined to have reached the preset state. If the filtered photoelectric pulse wave signals respectively reach the preset state, it is determined that the photoelectric pulse wave signal within the preset time period reaches the preset state.

8. The blood collection device according to claim 1, characterized in that, The blood collection device also includes a first storage area for storing used blood collection components and a second storage area for storing multiple spare blood collection components; the multiple spare blood collection components are stored in a vertically stacked manner; the blood collection device also includes a horizontal booster and a vertical booster for updating blood collection components; the blood collection component currently performing the blood collection operation is located at the second preset position of the operating table; The controller is further configured to, after performing the analysis operation, drive the lateral booster to push the current blood collection component into the first storage area; and drive the longitudinal booster to push the uppermost blood collection component among the plurality of spare blood collection components into the second preset position.

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