Microbeads for cosmetics and their applications

Abstract

Microbeads for cosmetics and their applications. The present application discloses a microbead and its application, wherein the microbead comprises an aqueous phase and an oil phase, wherein the oil phase is completely wrapped around the outside of the aqueous phase, and the oil phase comprises a solvent and a thickener, wherein the thickener is 6-15% and the solvent is 85-94% by mass percentage in the oil phase. The microbeads have good stability, and the microbeads are applied to cosmetics to isolate the active ingredients wrapped in the microbeads from other active substances in the cosmetic formula, thereby reducing mutual influence and improving the compatibility between the ingredients.

Description

Technical Field

[0001] The present application relates to the technical field of cosmetics, and in particular to micro beads for cosmetics and applications thereof. Background Art

[0002] With the development of cosmetics-related regulations, functional skin care products have become a trend. The functional ingredients in cosmetic formulas usually use a variety of raw materials in combination, but there are some incompatibility taboos for the functional ingredients of cosmetics. For example, blue copper peptides should first be avoided from being used simultaneously with strong oxidizing ingredients such as α-hydroxy acids and vitamin C; secondly, they should be avoided from being used simultaneously with substances with chelating effects, such as disodium ethylenediaminetetraacetic acid, which can chelate the copper ions in blue copper peptides, thereby changing the color of the blue copper peptide aqueous solution to green; in addition, because carnosine has a similar structure to tripeptide-1, carnosine will compete with tripeptide-1 for copper ions, causing the solution to turn purple; finally, blue copper peptides are pH-sensitive raw materials. When added to cosmetic formulas, the pH needs to be adjusted to around neutral. Too high or too low a pH will affect the stability of blue copper peptides.

[0003] In order to improve the stability of the functional ingredients, unstable functional ingredients can be encapsulated, for example, the functional ingredients can be prepared into liposomes, microcapsules, etc. However, such preparations will affect the release of the encapsulated functional ingredients. Summary of the invention

[0004] The inventors of the present application want to solve the above problems by encapsulating the functional ingredients with microbeads. Microbeads are independent microbeads visible to the naked eye, which can be added to a variety of cosmetic dosage forms and have a wide range of applications. However, when the inventors tried to use microbeads to encapsulate the functional ingredients, they found that the prepared microbeads would become unstable over time, making it impossible to ensure the stable existence of the functional ingredients encapsulated therein. In order to solve this technical problem, the present application provides microbeads with good stability, thereby completing the present invention.

[0005] The specific technical solutions of this application are as follows:

[0006] 1. A microbead comprising a water phase and an oil phase, wherein the oil phase is completely wrapped around the outside of the water phase, the oil phase comprises a solvent and a thickener, and in terms of the mass percentage in the oil phase, the thickener is 6-15% and the solvent is 85-94%.

[0007] 2. The microbeads according to item 1, wherein the volume ratio of the aqueous phase to the oil phase is 1:1.5-10.

[0008] 3. The microbeads according to item 1 or 2, wherein the solvent comprises one or more of caprylic / capric triglyceride, isononyl isononanoate, isopropyl myristate, dicaprylyl carbonate, C12-15 alcohol benzoate, ethylhexyl palmitate, ethylhexyl stearate, white meadowfoam seed oil, avocado tree butter, castor seed oil, wheat germ oil, carrot seed oil, annatto seed oil, ubiquinone, hairy palm fruit oil, sunflower seed oil, triheptyl, C13-15 alkane, C15-19 alkane and amino-terminated polydimethylsiloxane; preferably, the solvent comprises one or more of caprylic / capric triglyceride, isononyl isononanoate, white meadowfoam seed oil, avocado tree butter, castor seed oil, wheat germ oil, carrot seed oil, annatto seed oil, hairy palm fruit oil and sunflower seed oil.

[0009] 4. The microbeads according to any one of items 1 to 3, wherein the thickener comprises castor oil / IPDI copolymer and / or dextrin palmitate.

[0010] 5. The microbeads according to any one of items 1 to 4, wherein the aqueous phase contains an active ingredient.

[0011] 6. The microbeads according to any one of items 1 to 5, wherein the particle size of the microbeads is in the range of 0.1-10 mm.

[0012] 7. Use of the microbeads described in any one of items 1 to 6 in cosmetics.

[0013] 8. Use of the microbeads described in any one of items 1 to 6 for improving the stability of active ingredients.

[0014] 9. A cosmetic comprising the microbeads according to any one of items 1 to 6.

[0015] 10. The cosmetic according to item 9, wherein the microbeads account for 1-100% by mass in the cosmetic.

[0016] Effects of the Invention

[0017] The microbeads prepared in the present application have good stability. When the microbeads are applied to cosmetics, the functional ingredients in the microbeads are isolated from other active substances in the cosmetic formula, thereby reducing mutual influence and improving the stability and compatibility between the ingredients. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of a device for preparing microbeads according to a specific embodiment of the present application.

[0019] Figure 2 Schematic diagram of the microbeads obtained in Example 1. DETAILED DESCRIPTION

[0020] The present application is described in detail below in conjunction with the described embodiments. Although specific embodiments of the present application are shown, it should be understood that the present application can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided to enable a more thorough understanding of the present application and to enable the scope of the present application to be fully communicated to those skilled in the art.

[0021] It should be noted that certain words are used in the specification and claims to refer to specific components. Those skilled in the art should understand that technicians may use different nouns to refer to the same component. This specification and claims do not use the difference in nouns as a way to distinguish components, but use the functional differences of components as the criterion for distinction. As mentioned throughout the specification and claims, "including" or "comprising" are open-ended terms and should be interpreted as "including but not limited to". The subsequent description of the specification is a preferred embodiment of the present application, but the description is based on the general principles of the specification and is not intended to limit the scope of the present application. The scope of protection of the present application shall be determined by the attached claims.

[0022] The present application provides a microbead comprising a water phase and an oil phase, wherein the oil phase is completely wrapped around the outside of the water phase, and the oil phase comprises a solvent and a thickener, wherein the thickener is 6-15% and the solvent is 85-94% in terms of mass percentage in the oil phase.

[0023] In some embodiments, the thickener may be 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, etc., based on the mass percentage in the oil phase; the solvent may be 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, etc.

[0024] In some embodiments, the oil phase further includes oil-soluble active substances, such as ceramide, sphingosine, plant essential oils, oil-soluble antioxidants, essences, and the like.

[0025] In some embodiments, the volume ratio of the water phase to the oil phase is 1:1.5-10. When the volume ratio is less than 1:1.5, the microbeads sometimes cannot wrap the water phase components or are easily broken, and when the volume ratio is greater than 1:10, there will be a phenomenon of poor skin feel.

[0026] For example, the volume ratio of the water phase to the oil phase can be 1:1.5, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, etc.

[0027] In some embodiments, the solvent includes one or more of caprylic / capric triglyceride, isononyl isononanoate, isopropyl myristate, dicaprylyl carbonate, C12-15 alcohol benzoate, ethylhexyl palmitate, ethylhexyl stearate, white meadowfoam seed oil, avocado tree fruit butter, castor seed oil, wheat germ oil, carrot seed oil, annatto seed oil, ubiquinone, hairy palm fruit oil, sunflower seed oil, triheptyl, C13-15 alkane, C15-19 alkane and amino-terminated polydimethylsiloxane, preferably includes one or more of caprylic / capric triglyceride, isononyl isononanoate, white meadowfoam seed oil, avocado tree fruit butter, castor seed oil, wheat germ oil, carrot seed oil, annatto seed oil, hairy palm fruit oil and sunflower seed oil.

[0028] In some embodiments, the thickener includes castor oil / IPDI copolymer and / or dextrin palmitate.

[0029] In some embodiments, the aqueous phase contains active ingredients, and the active ingredients include unstable active ingredients and stable active ingredients. For example, the unstable active ingredients include blue copper peptide, cyanocobalamin, ascorbic acid and its derivatives.

[0030] In some embodiments, the particle size of the microbeads ranges from 0.1 to 10 mm. For example, the particle size can be 0.2 mm, 0.3 mm, 0.4 mm, 0.5 mm, 0.6 mm, 0.7 mm, 0.8 mm, 0.9 mm, 1 mm, 1.5 mm, 2 mm, 2.5 mm, 3 mm, 3.5 mm, 4 mm, 4.5 mm, 5 mm, 5.5 mm, 6 mm, 6.5 mm, 7 mm, 7.5 mm, 8 mm, 8.5 mm, 9 mm, 9.5 mm, etc.

[0031] The present application also provides the application of the above-mentioned microbeads in cosmetics.

[0032] The present application also provides the use of the above-mentioned microbeads in improving the stability of active ingredients.

[0033] The present application also provides a cosmetic comprising the above-mentioned microbeads.

[0034] In some embodiments, the microbeads are present in an amount of 1-100% by mass in the cosmetic, and may be specifically 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, etc.

[0035] In some embodiments, in addition to the microbeads, the cosmetics may also contain cosmetically acceptable excipients, other active ingredients, etc. The cosmetics acceptable excipients include but are not limited to solvents, thickeners, preservatives, flavors, etc., and the other active ingredients include but are not limited to vitamin C, vitamin B12, carnosine, etc.

[0036] In the present application, there is no limitation on the method for preparing the aqueous phase, which can be prepared according to conventional methods in the art, for example, the active ingredient can be dissolved in water to obtain an aqueous solution containing the active ingredient.

[0037] In the present application, there is no limitation on the preparation method of the oil phase, which can be prepared according to conventional methods in the art, such as mixing and heating the solvent and the thickener, and then homogenizing to obtain the oil phase, such as heating and dissolving at 85-95°C, and homogenizing at 2000-15000 rpm for 3-10 minutes, preferably keeping warm after homogenization to obtain the oil phase, preferably, keeping warm at 85-95°C for 10-40 minutes to obtain the oil phase.

[0038] In some embodiments, the oil phase further comprises an oil-soluble active substance, including but not limited to ceramide, sphingosine, plant essential oils, oil-soluble antioxidants, essences, and the like.

[0039] For example, the solution can be heated at 85°C, 86°C, 87°C, 88°C, 89°C, 90°C, 91°C, 92°C, 93°C, 94°C, or 95°C and homogenized at 2000rpm, 3000rpm, 4000rpm, 5000rpm, 6000rpm, 7000rpm, 8000rpm, 9000rpm, 10000rpm, 11000rpm, 12000rpm, 13000rpm, 14000rpm, or 15000rpm for 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, or 10 minutes.

[0040] The oil phase can be obtained by keeping warm at 85°C, 86°C, 87°C, 88°C, 89°C, 90°C, 91°C, 92°C, 93°C, 94°C, 95°C for 10 minutes, 15 minutes, 20 minutes, 25 minutes, 30 minutes, 35 minutes, 40 minutes, etc.

[0041] In this application, there is no limitation on the preparation method of microbeads, which can be prepared by a microfluidic device, or by a suspension polymerization method, a traditional mechanical stirring method, etc., preferably by a microfluidic device.

[0042] Microfluidics is a method commonly used by technicians in this field to prepare microspheres or emulsions. It uses microchannels in microfluidic devices to manipulate, process and control trace amounts of liquids or samples on a microscopic scale. Microfluidic technology is generally divided into two steps: (1) emulsion formation, that is, monomers or polymer fluids are emulsified in microfluidic channels to form droplets; (2) emulsion solidification or polymerization, where the emulsion droplets formed by emulsification are then solidified in situ to form microspheres or emulsion droplets. The solidification methods mainly include polymerization, freezing and solvent evaporation.

[0043] In some embodiments, the flow ratio of the water phase to the oil phase during the preparation process is 1:3-20.

[0044] For example, the flow ratio of the water phase to the oil phase can be 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, etc.

[0045] In some embodiments, the continuous phase contains water. In some embodiments, the continuous phase also contains additives. In the present application, the specific type of additives is not limited in the present application, and it can be conventionally selected as needed. For example, the additives can be thickeners, alcohol solvents, alkali agents, and preservatives. The thickeners include xanthan gum, cellulose, or carbomer; the alcohol solvents include glycerol, butylene glycol, pentanediol, hexylene glycol, and caprylyl glycol; the alkali agents include sodium hydroxide, aminomethyl propanol, triethanolamine, and arginine; the preservatives include p-hydroxyacetophenone, phenoxyethanol, and the like.

[0046] In the present application, there is no limitation on the content of the additive in the continuous phase, and the additive can be added according to the conventional amount in the art. For example, the amount of the additive can be 0.5-10%.

[0047] For example, the additive may be used in an amount of 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, etc.

[0048] In some embodiments, the application does not impose any restrictions on the amount of thickener in the continuous phase, and it can be added according to the conventional amount in the art, for example, the thickener can be 0.01-0.1%. For example, the thickener can be 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, etc.

[0049] In the present application, the viscosity of the continuous phase is 10-300 cP. For example, the viscosity of the continuous phase can be 15 cP, 20 cP, 25 cP, 50 cP, 100 cP, 150 cP, 200 cP, 250 cP, etc.

[0050] In the present application, there is no limitation on the method for measuring the viscosity of the continuous phase, which can be measured according to conventional methods in the art, for example, by using a rotational viscometer.

[0051] Figure 1It is a schematic diagram of an exemplary device for preparing the microbeads described in the present application, wherein 1 is the water phase inlet, 2 is the oil phase inlet, and 3 is the continuous phase inlet. The water phase, oil phase and continuous phase enter from the corresponding inlets respectively, and the microbeads are obtained by microfluidic technology.

[0052] The composition described in this application is not limited to the preparation of the device described above.

[0053] The microbeads prepared in the present application have good stability. When used in cosmetics, they can reduce the mutual influence between the encapsulated active ingredients and other unencapsulated active ingredients, and improve the compatibility between the ingredients.

[0054] Example

[0055] The present application provides a general and / or specific description of the materials and test methods used in the experiments. In the following examples, unless otherwise specified, % means wt%, i.e., weight percentage. The reagents or instruments used without indicating the manufacturer are all conventional reagent products that can be obtained commercially.

[0056] Example 1 Preparation of microbeads

[0057] Preparation of oil phase: caprylic acid / capric acid triglyceride and castor oil / IPDI copolymer are mixed and heated to 85° C., dissolved into a transparent liquid and then homogenized. The homogenization conditions are homogenization at 10,000 rpm for 10 minutes, and then kept warm in a water bath at 85° C. for 20 minutes to obtain an oil phase, wherein, in terms of mass percentage in the oil phase, the caprylic acid / capric acid triglyceride is 90% and the castor oil / IPDI copolymer is 10%.

[0058] Preparation of aqueous phase: Dissolve blue copper peptide in purified water to obtain a blue copper peptide aqueous solution with a concentration of 3 wt%.

[0059] Preparation of the continuous phase: 5% butanediol, 3% pentanediol and 0.1% xanthan gum were dissolved in pure water as a continuous phase. The viscosity of the continuous phase was measured using a rotational viscometer and was 30 cP.

[0060] Preparation of microbeads: Keep the water phase, oil phase and continuous phase at 85°C and add Figure 1 The microbeads were prepared in the microfluidic device shown in FIG. 1 , wherein the radius of the microbeads was 0.6 mm, the volume ratio of the water phase to the oil phase was 1:1.5, and the volume ratio of the oil phase to the water phase was calculated by measuring the radius of the microbeads. The schematic diagram of the prepared microbeads is shown in FIG. Figure 2 As shown, 4 is the water phase and 5 is the oil phase.

[0061] Example 2 Preparation of microbeads

[0062] The difference between Example 2 and Example 1 is that in the oil phase of Example 2, caprylic acid / capric acid triglyceride is 94%, castor oil / IPDI copolymer is 6%, and the radius of the microbeads measured according to the method described in Example 1 is 0.62 mm, and the volume ratio of the water phase to the oil phase of the microbeads is 1:5.

[0063] Example 3 Preparation of microbeads

[0064] The difference between Example 3 and Example 1 is that in the oil phase of Example 3, caprylic acid / capric acid triglyceride is 85%, castor oil / IPDI copolymer is 15%, and the radius of the microbeads measured according to the method described in Example 1 is 0.87 mm, and the volume ratio of the water phase to the oil phase of the microbeads is 1:8.

[0065] Example 4 Preparation of microbeads

[0066] Preparation of oil phase: caprylic / capric triglyceride, white meadowfoam seed oil and castor oil / IPDI copolymer are mixed and heated to 90°C, dissolved into a transparent liquid and then homogenized. The homogenization conditions are homogenization at 2000rpm for 7 minutes, and then kept warm in a 90°C water bath for 30 minutes to obtain an oil phase, wherein, in terms of mass percentage in the oil phase, the caprylic / capric triglyceride is 45%, the white meadowfoam seed oil is 45%, and the castor oil / IPDI copolymer is 10%.

[0067] Preparation of aqueous phase: Dissolve blue copper peptide in purified water to obtain a blue copper peptide aqueous solution with a concentration of 3 wt%.

[0068] Preparation of continuous phase: 2% glycerol, 0.5% caprylyl glycol, 0.5% hexylene glycol, and 0.03% carbomer were dissolved in pure water. After complete dissolution, the mixture was neutralized with aminomethyl propanol to pH 6.5-7.5 and used as the continuous phase. The viscosity of the continuous phase was measured in the same manner as in Example 1 and was 150 cP.

[0069] Preparation of microbeads: Keep the water phase, oil phase and continuous phase at 90°C and add Figure 1 Microbeads were prepared in the microfluidic device shown, wherein the radius of the microbeads was 0.71 mm as measured by the method described in Example 1, and in the obtained microbeads, the volume ratio of the water phase to the oil phase was 1:4.

[0070] Example 5 Preparation of microbeads

[0071] Preparation of oil phase: Mix and heat the lithospermum root extract, isononyl isononanoate, caprylic / capric triglyceride, castor oil / IPDI copolymer, white meadowfoam seed oil and avocado tree fat to 95°C, dissolve into a transparent liquid and then homogenize. The homogenization condition is homogenizing at 15000rpm for 7mins, and then keep warm in a 95°C water bath for 40mins to obtain an oil phase, wherein, in terms of mass percentage in the oil phase, the lithospermum root extract is 2%, the isononyl isononanoate is 40%, the caprylic / capric triglyceride is 30%, the castor oil / IPDI copolymer is 10%, the white meadowfoam seed oil is 15%, and the avocado tree fat is 3%.

[0072] Preparation of aqueous phase: Dissolve blue copper peptide in purified water to obtain a blue copper peptide aqueous solution with a concentration of 3 wt%.

[0073] Preparation of continuous phase: 0.5% p-hydroxyacetophenone, 0.5% hexylene glycol, and 0.01% carbomer were dissolved in pure water. After complete dissolution, the mixture was neutralized with aminomethyl propanol to pH 6.5-7.5 and used as the continuous phase. The viscosity of the continuous phase was measured in the same manner as in Example 1 and was 50 cP.

[0074] Preparation of microbeads: Keep the water phase, oil phase and continuous phase at 95°C and add Figure 1 Microbeads were prepared in the microfluidic device shown, wherein the radius of the microbeads was 0.72 mm as measured by the method described in Example 1, and in the obtained microbeads, the volume ratio of the water phase to the oil phase was 1:10.

[0075] Comparative Example 1 Preparation of microbeads

[0076] The difference between Comparative Example 1 and Example 1 is that, in terms of mass percentage of the oil phase in Comparative Example 1, the caprylic / capric triglyceride is 95% and the castor oil / IPDI copolymer is 5%. The microbeads prepared according to the above oil phase formula showed the phenomenon of water phase escaping within 24 hours.

[0077] Comparative Example 2

[0078] The difference between Comparative Example 2 and Example 1 is that jojoba seed oil is added in Comparative Example 2 instead of avocado oil, and the addition ratio is the same.

[0079] The prepared microbeads are turbid and opaque, and the turbid microbeads cannot well present the color of the blue copper peptide.

[0080] Table 1 Content of each component in the embodiment

[0081]

[0082] Experimental Example 1: Stability Experiment

[0083] The above Examples 1-5 were subjected to a stability test. The prepared microbeads were placed in an environment of 4°C, room temperature, and 45°C to test their stability for 1, 3, and 6 months, respectively. The results are shown in Table 2.

[0084] Table 2 Stability of microbeads

[0085]

[0086] Experimental Example 2 Application Experiment

[0087] Preparation of 1# and 3# essences:

[0088] (1) Weigh glycerol, butanediol and 1,2-pentanediol and add them into a beaker, then add acrylic acid (ester)

[0089] C10-30 Alkyl Acrylate Crosspolymer and Xanthan Gum, stir and disperse evenly, then add purified water;

[0090] (2) After the solution of step (1) is completely dissolved, 18% sodium hydroxide solution is added to neutralize;

[0091] (3) Add the microbeads prepared in Example 1 (the added amount is 10% of the essence), EDTA-2Na and carnosine, and stir to dissolve into a transparent liquid, wherein the pH of the 1# essence is 7.0; and the pH of the 3# essence is adjusted to 4.5 with citric acid.

[0092] Preparation method of 2# and 4# essence:

[0093] (1) Weighing glycerol, butylene glycol and 1,2-pentanediol into a beaker, adding acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer and xanthan gum, stirring and dispersing evenly, and then adding purified water;

[0094] (2) After the solution of step (1) is completely dissolved, 18% sodium hydroxide solution is added to neutralize;

[0095] (3) Add blue copper peptide (the amount added is 0.3% of the essence), EDTA-2Na and carnosine, stir and dissolve into a transparent liquid, wherein the pH of the 2# essence is 7.0; and the pH of the 4# essence is adjusted to 4.5 with citric acid.

[0096] The formula of the essence prepared above is shown in Table 3:

[0097] Table 3 Essence formula

[0098]

[0099]

[0100] The color changes of the blue copper peptides in the 1#-4# essences were observed, and the results are shown in Table 4:

[0101] Table 4 Stability results of samples 1# to 4#

[0102]

[0103] As shown in Table 4, the 1# essence and 3# essence added with the microbeads of the present application did not show any color change of the blue copper peptide, while the 2# essence and 4# essence without the microbeads of the present application changed color at the beginning of addition, and the color continued to change as time went on. This shows that the oil gel of the present application is also stable during long-term storage, and such stability can effectively maintain the stability of the blue copper peptide.

[0104] The above is only the preferred embodiment of the present application, and does not limit the present application in other forms. Any technician familiar with the profession may use the above disclosed technical content to change or modify it into an equivalent embodiment with equivalent changes. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the present application without departing from the technical solution of the present application still falls within the protection scope of the technical solution of the present application.

Claims

1. A microbead comprising a water phase and an oil phase, wherein the oil phase is completely wrapped around the outside of the water phase, and the oil phase comprises a solvent and a thickener, wherein the thickener is 6-15% and the solvent is 85-94% by mass percentage in the oil phase; The solvent includes one or more of caprylic / capric triglyceride, isononyl isononanoate, isopropyl myristate, dicaprylyl carbonate, C12-15 alcohol benzoate, ethylhexyl palmitate, ethylhexyl stearate, white meadowfoam seed oil, avocado tree butter, castor seed oil, wheat germ oil, carrot seed oil, mahogany seed oil, ubiquinone, hair palm fruit oil, sunflower seed oil, triheptyl and amino dimethicone; The thickener includes castor oil / IPDI copolymer; The volume ratio of the water phase to the oil phase is 1:1.5-10.

2. The microbead according to claim 1, wherein The solvent includes one or more of caprylic / capric triglyceride, isononyl isononanoate, meadowfoam seed oil, avocado tree butter, castor seed oil, wheat germ oil, carrot seed oil, mahogany seed oil, crude palm fruit oil, and sunflower seed oil. The microbeads according to claim 1 , wherein the aqueous phase contains an active ingredient. The microbeads according to any one of claims 1 to 3, wherein the particle size of the microbeads is in the range of 0.1 to 10 mm.

5. Use of the microbeads according to any one of claims 1 to 4 in the preparation of cosmetics.

6. Use of the microbeads according to claim 3 in improving the stability of the active ingredient.

7. A cosmetic comprising the microbeads according to any one of claims 1 to 4.

8. The cosmetic according to claim 7, wherein: Calculated by mass percentage in the cosmetics, the micro beads account for 1-100%.

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