Use of a carbon-silicon composite chiral heterojunction membrane in chiral molecule / ion sieving

Abstract

The application provides application of a carbon-silicon composite component chiral heterojunction membrane in chiral molecule / ion sieving, and belongs to the technical field of membrane science and technology.The application has the following characteristics: the carbon-silicon composite component chiral heterojunction membrane is used to selectively recognize and sieve chiral molecules or ions by using the concentration difference driving force, and the carbon-silicon composite component chiral heterojunction membrane is composed of a macroporous anodic aluminum oxide array and a chiral mesoporous carbon-silicon composite nanomaterial.Compared with the prior art, the carbon-silicon composite component chiral heterojunction membrane has asymmetric chemical composition, asymmetric pore structure, asymmetric surface charge distribution and enhanced surface electric property, and is used to sieve chiral molecules or ions under the action of a concentration gradient, so that the operation is simple, the sieving effect is good, and the carbon-silicon composite component chiral heterojunction membrane has considerable application prospect in the field of chiral sieving.

Description

Technical Field

[0001] This invention belongs to the field of membrane science and technology, specifically relating to the application of a carbon-silicon composite chiral heterojunction membrane in chiral molecule / ion sieving. Background Technology

[0002] The 125th anniversary special issue of *Science* listed "Why Life Needs Chirality" as the fifth most challenging scientific question, highlighting its importance. Currently, approximately 88% of commercially available chiral drugs are racemic mixtures composed of equal amounts of enantiomers. Enantiomers of the same drug have similar physicochemical properties, but can produce different or even opposite effects in pharmacodynamics and toxicity. For example, the chiral drug thalidomide has an R-form used as a sedative to treat leprosy, while the S-form is a major cause of birth defects. Modern drug research and development requires the separation and testing of enantiomers of all bioactive molecules. However, how to efficiently separate chiral enantiomers remains a major challenge in the field of sieving. Current mainstream chiral separation techniques rely on chromatography, but this method is costly and time-consuming. Membrane separation technology generally possesses advantages such as simple processes, low cost, and environmental friendliness, making it an important research topic in the field of sieving. Furthermore, compared to traditional methods, membrane separation technology has a broader prospect for industrial applications and holds great promise for widespread application in industrial development in the future.

[0003] Chiral supramolecular structures, characterized by structural asymmetry, overcome the limitations of traditional covalent synthesis methods for preparing chiral materials, fundamentally expanding the research scope of the chiral field and considered a crucial option for solving the aforementioned problems. However, research on fabricating nanochannels using supramolecular templates is relatively limited. Until 2019, we demonstrated that supramolecular guanylic acid, through chiral transcription, can prepare mesoporous silica materials with chiral pore structures, enabling chiral recognition. However, single-component chiral silica is often limited by its inherent properties (such as poor conductivity and fluidity), resulting in low sieving efficiency and difficulty in device fabrication. In contrast, bicomponent or multicomponent heterostructures, which integrate different components, not only enable the device fabrication of supramolecular-based chiral materials through interfacial bonding but also synergistically enhance the selective sieving performance of heterostructure films. Summary of the Invention

[0004] This invention is made to solve the above-mentioned problems, and aims to provide an application of a carbon-silicon composite chiral heterojunction membrane in chiral molecule / ion sieving.

[0005] This invention provides an application of a carbon-silicon composite chiral heterojunction membrane in the sieving of chiral molecules / ions, characterized by the following: the carbon-silicon composite chiral heterojunction membrane is used to selectively identify and sieve chiral molecules or ions using concentration-driven force. The carbon-silicon composite chiral heterojunction membrane is composed of a macroporous anodic alumina array and chiral mesoporous carbon-silicon composite nanomaterials.

[0006] In the application of the carbon-silicon composite chiral heterojunction membrane provided by the present invention in the sieving of chiral molecules / ions, it may also have the following characteristics: when the carbon-silicon composite chiral heterojunction membrane is used to selectively identify and sieve chiral molecules or ions, one side of the carbon-silicon composite chiral heterojunction membrane is an equal amount of racemic chiral molecule or ion solution, and the other side is deionized water.

[0007] In the application of the carbon-silicon composite chiral heterostructure membrane provided by the present invention in chiral molecule / ion sieving, it may also have the following characteristics: wherein the anodic alumina array side of the carbon-silicon composite chiral heterostructure membrane is deionized water, and the chiral mesoporous carbon-silicon composite nanomaterial side is an equal amount of racemic chiral molecule or ion solution.

[0008] In the application of the carbon-silicon composite chiral heterojunction membrane provided by this invention in the sieving of chiral molecules / ions, it can also have the following characteristics: when the carbon-silicon composite chiral heterojunction membrane is used to selectively identify and sieve chiral molecules or ions, two semi-conductivity cells are used, the carbon-silicon composite chiral heterojunction membrane is placed between the two semi-conductivity cells, and equal amounts of racemic chiral molecule or ion solution and deionized water are added to the two semi-conductivity cells respectively, and then allowed to stand.

[0009] In the application of the carbon-silicon composite chiral heterojunction membrane provided by this invention in chiral molecule / ion sieving, it can also have the following characteristic: wherein the concentration of the equal amount of racemic chiral molecules or ions in the solution is 10. -2 -10 -5 M, let stand for 12-24 hours.

[0010] In the application of the carbon-silicon composite chiral heterojunction membrane provided by the present invention in the sieving of chiral molecules / ions, it can also have the following characteristics: wherein, the equal amounts of racemic chiral molecules or ion solutions include chiral amino acid molecules with different isoelectric points.

[0011] In the application of the carbon-silicon composite chiral heterojunction membrane provided by the present invention in chiral molecule / ion sieving, it may also have the following characteristics: wherein the chiral amino acids include L-configuration arginine and D-configuration arginine.

[0012] In the application of the chiral heterojunction membrane of the carbon-silicon composite component provided by the present invention in the sieving of chiral molecules / ions, it can also have the following characteristics: wherein the chiral heterojunction membrane of the carbon-silicon composite component is vertically arranged between two semi-conductivity cells, the anodic aluminum oxide array is in direct contact with deionized water, and the chiral mesoporous carbon-silicon composite nanomaterial is in direct contact with an equal amount of racemic chiral molecules or ion solution.

[0013] In the application of the carbon-silicon composite chiral heterojunction membrane provided by this invention in chiral molecule / ion sieving, it can also have the following characteristics: the preparation method of the carbon-silicon composite chiral heterojunction membrane includes: uniformly dispersing the carbon-silicon composite chiral mesoporous nanomaterial in an aqueous solution and adding it to an anodic aluminum oxide membrane, removing the solvent by filtration and drying to obtain the carbon-silicon composite chiral heterojunction membrane, wherein the carbon-silicon composite chiral mesoporous nanomaterial is prepared by hydrothermal method using guanylic acid as a template agent.

[0014] In the application of the chiral heterojunction membrane of carbon-silicon composite components provided by this invention in chiral molecule / ion sieving, it can also have the following characteristics: the preparation method of the chiral heterojunction membrane of carbon-silicon composite components includes: Step 1, guanylic acid and potassium chloride are simultaneously dispersed or dissolved in deionized water, 37% concentrated hydrochloric acid and 3-aminopropyltriethoxysilane are added under stirring conditions, stirring is continued, and tetraethyl orthosilicate and soluble phenolic resin are added dropwise, and stirring is carried out at room temperature for a period of time; Step 2, the mixed solution obtained in Step 1 is transferred to a hydrothermal reactor, and hydrothermal reaction is carried out at 80℃~120℃ for 24h~120h, and then filtered and dried to obtain a chiral carbon-silicon composite material with a template; Step 3, the chiral carbon-silicon composite material with the template is added to a mixed solution of concentrated hydrochloric acid and anhydrous ethanol. The material is heated in a medium, then filtered and dried to obtain a chiral carbon-silicon composite mesoporous material with the amino-modified inner surface removed from the template; Step 4, the chiral carbon-silicon composite mesoporous material obtained in Step 3 is calcined in an inert gas at 500℃~1000℃ for 3h~5h to obtain a carbon-silicon composite chiral mesoporous nanomaterial. In Step 1, the molar ratio of tetraethyl orthosilicate to soluble phenolic resin is 1:0.75, the mass-volume ratio of guanylic acid to 3-aminopropyltriethoxysilane is (0.4-0.7)g:(0.70-1.00)ml, the mass-volume ratio of guanylic acid to tetraethyl orthosilicate is (0.4-0.7)g:(0.79-1.12)ml, and the mass-volume ratio of guanylic acid to concentrated hydrochloric acid is (0.4-0.7)g:(0.12-0.26)ml.

[0015] Compared with the prior art, the present invention has the following advantages:

[0016] 1. This invention utilizes a chiral heterostructured carbon-silicon composite membrane with asymmetric chemical composition, asymmetric channel structure, and asymmetric surface charge distribution to sieve chiral molecules or ions under the action of a concentration gradient. The operation is simple and the sieving effect is good, showing considerable application prospects in the field of chiral sieving.

[0017] 2. The carbon-silicon composite chiral heterojunction membrane of the present invention is prepared by filtration growth of a layer of carbon-silicon composite chiral mesoporous nanomaterial on an AAO substrate through an interfacial superassembly strategy. It has an asymmetric chemical composition, an asymmetric channel structure, and an asymmetric surface charge distribution. In addition, the chiral material, as an ion-selective layer, also has an asymmetric chiral pore structure and a chiral layer with enhanced surface charge. These asymmetric elements and enhanced electromechanical properties endow the heterojunction membrane with superior chiral recognition and sieving performance.

[0018] 3. The chiral heterojunction membrane of the carbon-silicon composite component of the present invention has high mechanical stability, regular and ordered pore structure, adjustable film thickness, and surface-enhanced charge. These advantages greatly reduce the internal resistance of ion transport, which is beneficial to the application of heterojunction membranes in ion selective transport and energy conversion.

[0019] 4. This invention provides an efficient separation and analysis method for chiral heterojunction membranes of functionally superassembled carbon-silicon composite components, and provides a two-dimensional / one-dimensional heterojunction nanochannel membrane and its application in the field of chiral drug screening.

[0020] 5. The chiral heterogeneous membrane of the carbon-silicon composite component of the present invention can selectively pass through D-configuration arginine, exhibiting excellent chiral sieving effect. Attached Figure Description

[0021] Figure 1 The transmission electron microscope (TEM) images of the carbon-silicon composite chiral mesoporous nanocomposite material prepared according to the embodiments of the present invention are shown below.

[0022] Figure 2 The nitrogen adsorption-desorption curves of the carbon-silicon composite chiral mesoporous nanocomposite material prepared in the embodiments of the present invention are shown below.

[0023] Figure 3 This is the pore size distribution curve of the carbon-silicon composite chiral mesoporous nanocomposite material prepared according to the embodiments of the present invention;

[0024] Figure 4 This is a surface scanning electron microscope image of the MCSC / AAO heterostructured nanochannel prepared according to an embodiment of the present invention;

[0025] Figure 5 This is a cross-sectional scanning electron microscope image of the MCSC / AAO heterostructured nanochannel prepared according to an embodiment of the present invention;

[0026] Figure 6 Contact angle test diagram of the MCSC / AAO heterojunction membrane nanochannel prepared in an embodiment of the present invention;

[0027] Figure 7 The figure shows the current response results of MCSC / AAO heterostructured membrane nanochannels to two configurations (L-type and D-type) of arginine obtained in the embodiments of the present invention.

[0028] Figure 8 The chiral sieving results of MCSC / AAO heterojunction membrane nanochannels obtained in the embodiments of the present invention. Figure 1 ;

[0029] Figure 9 The chiral sieving results of MCSC / AAO heterostructured membrane nanochannels for two configurations (L-type and D-type) of arginine obtained in the embodiments of the present invention are as follows. Figure 2 . Detailed Implementation

[0030] To make the technical means, creative features, objectives and effects of this invention easier to understand, the following embodiments, in conjunction with the accompanying drawings, specifically illustrate the application of the carbon-silicon composite chiral heterostructure membrane of this invention in chiral molecule / ion sieving.

[0031] <Example>

[0032] This embodiment provides an application of a carbon-silicon composite chiral heterojunction membrane in chiral molecule / ion sieving, which specifically includes the following steps:

[0033] Step 1: Fabrication of CMS / AAO heterojunction membranes based on an interface superassembly strategy:

[0034] 1) Weigh 0.6g of guanylic acid white powder and 0.22g of potassium chloride solid powder using an analytical balance, then disperse or dissolve them in about 21ml of deionized water solution, and stir at 300 rpm for about 1 hour on a magnetic stirrer to obtain the first mixed solution;

[0035] 2) Measure 0.24 mL of 37% concentrated hydrochloric acid and add it to the first mixed solution above, which is stirred continuously, to obtain the second mixed solution;

[0036] 3) Measure 0.95 ml of 3-aminopropyltriethoxysilane (APTES) and add it to the second mixed solution above while stirring continuously to obtain the third mixed solution;

[0037] 4) Measure 1.11 ml of tetraethyl orthosilicate (TEOS), slowly add TEOS dropwise to the third mixed solution above, stir at room temperature for 30 min to obtain the fourth mixed solution;

[0038] 5) Measure 0.83 mL of soluble phenolic resin and add it to the fourth mixed solution above. Stir at room temperature for 12 h to obtain the fifth mixed solution.

[0039] 6) Transfer the above fifth mixed solution to a hydrothermal reactor and place it in an oven at 100°C for hydrothermal reaction for 48 hours to obtain the sixth mixed solution;

[0040] 7) Filter the above sixth mixed solution through a Buchner funnel;

[0041] 8) Place the sample filtered in step 7) in a room temperature environment for 24 hours to allow the sample to dry naturally, and obtain the first dried sample;

[0042] 9) Prepare a mixed solution of 37% concentrated hydrochloric acid and anhydrous ethanol in a 3:7 ratio, and set aside for later use;

[0043] 10) Weigh 0.5g of the first dried sample and add it to the above-prepared mixed solution of concentrated hydrochloric acid and anhydrous ethanol according to the ratio (add 10ml of mixed solution for every 0.1g of sample) to obtain the seventh mixed solution;

[0044] 11) Transfer the above seventh mixed solution to an oil bath and incubate at 60°C for 12 hours to obtain the eighth mixed solution;

[0045] 12) Filter the above eighth mixed solution through a Buchner funnel;

[0046] 13) Place the sample filtered in step 12) in a room temperature environment for 24 hours to allow the sample to dry naturally, and obtain a second dried sample. The second dried sample is a chiral carbon silicon composite mesoporous material with the amino-modified inner surface removed from the template.

[0047] 14) The second dried sample was calcined at 800°C for 3 hours under a nitrogen atmosphere to obtain a carbon-silicon composite chiral mesoporous nanocomposite material.

[0048] 15) Prepare an ethanol mixture of anhydrous ethanol and deionized water in a 2:5 ratio;

[0049] 16) Tightly attach the anodized aluminum membrane (also called anodized aluminum array or AAO substrate) to the surface of the filtration device and set up the filtration device.

[0050] 17) The carbon-silicon composite chiral mesoporous nanocomposite material was dispersed in the above ethanol mixed solution to obtain the ninth mixed solution;

[0051] 18) The above ninth mixed solution is ultrasonically vibrated to uniformly disperse the nanomaterials in the solution, thus obtaining a dispersion solution;

[0052] 19) The above dispersion solution is filtered onto the AAO substrate through the above filtration device to obtain the final carbon silicon composite chiral mesoporous heterostructured membrane MCSC / AAO with a carbon silicon composite chiral pore structure, denoted as MCSC / AAO heterostructured membrane nanochannel.

[0053] Step 2: Combine the MCSC / AAO heterojunction nanochannel with a conductivity cell to form a chiral sieving device: Place the MCSC / AAO heterojunction nanochannel vertically between two half-conductivity cells.

[0054] Step 3: Two arginine configuration solutions were added to one of the two half-conductivity cells, and deionized water was added to the other half-conductivity cell. The mixture was allowed to stand for 24 hours. The two arginine configurations were then chirally sieved using the concentration gradient across the MCSC / AAO heterojunction nanochannel. The concentration of both arginine configuration solutions was 10... -3 M, a carbon-silicon composite chiral mesoporous nanocomposite material of MCSC / AAO heterostructured nanochannels is in direct contact with arginine solutions of two configurations, and an anodic aluminum oxide array of MCSC / AAO heterostructured nanochannels is in direct contact with deionized water.

[0055] Performance testing of MCSC / AAO heterojunction membrane nanochannels:

[0056] Figure 1 This is a transmission electron microscope (TEM) image of the carbon-silicon composite chiral mesoporous nanocomposite material prepared according to an embodiment of the present invention.

[0057] like Figure 1 As shown, the carbon-silicon composite chiral mesoporous nanocomposite material prepared in this embodiment has a regular mesoporous channel structure.

[0058] Figure 2 The nitrogen adsorption-desorption curves of the carbon-silicon composite chiral mesoporous nanocomposite material prepared in the embodiments of the present invention are shown below. Figure 3 This is the pore size distribution curve of the carbon-silicon composite chiral mesoporous nanocomposite material prepared according to the embodiments of the present invention.

[0059] like Figure 2 As shown in the nitrogen adsorption-desorption curves, the adsorption and desorption curves almost overlap within a narrow pressure range, indicating that the prepared carbon-silicon composite chiral mesoporous nanocomposite material has a narrow pore size distribution structure. Figure 3 As shown in the figure, the pore size distribution curve obtained by the desorption value shows that the pore size of the carbon-silicon composite chiral mesoporous nanocomposite is approximately 2.4 nm.

[0060] Figure 4 This is a surface scanning electron microscope image of the MCSC / AAO heterostructured nanochannel prepared according to an embodiment of the present invention; Figure 5 This is a cross-sectional scanning electron microscope image of the MCSC / AAO heterostructured nanochannel prepared according to an embodiment of the present invention.

[0061] like Figure 4 As shown in the surface image of the MCSC / AAO heterostructured nanochannel, the carbon-silicon composite chiral mesoporous nanocomposite material is smooth and completely covered on the AAO substrate; as shown in the image. Figure 5 As shown in the cross-sectional view of the MCSC / AAO heterostructure, the carbon-silicon composite chiral mesoporous nanocomposite material is tightly adsorbed on the upper layer of the AAO substrate, with a thickness of approximately 70 μm.

[0062] Figure 6 The contact angle test diagram of the MCSC / AAO heterojunction nanochannel prepared according to the embodiment of the present invention is shown.

[0063] like Figure 6 As shown in the figure, the MCSC / AAO heterostructured nanochannels are still hydrophilic materials.

[0064] Furthermore, this embodiment also investigated the chiral configuration of MCSC / AAO heterostructured membrane nanochannels, as detailed below:

[0065] Equal volumes of a single-configuration chiral amino acid solution were added to two semi-conductance cells of a chiral sieving device. The two semi-conductance cells were connected to a picoammeter to activate the circuit, thereby detecting the current response of the single-configuration chiral amino acid through the heterostructure film. The current response of another single configuration of the same chiral amino acid through the heterostructure film was detected in the same manner. In this way, by detecting the current response of molecules or ions of the same amino acid with different configurations through the heterostructure film, the chiral configuration of the MCSC / AAO heterostructure nanochannel can be determined. In this embodiment, the current response of two configurations (L-type and D-type) of arginine through the heterostructure film was specifically detected.

[0066] Figure 7 The figure shows the current response results of MCSC / AAO heterostructured membrane nanochannels to two configurations (L-type and D-type) of arginine obtained in the embodiments of the present invention.

[0067] like Figure 7 As shown, the current through which D-configuration arginine passes through the MCSC / AAO heterostructure nanochannel is greater than the current value obtained by testing L-configuration arginine through the MCSC / AAO heterostructure nanochannel, proving that the MCSC / AAO heterostructure nanochannel is a thin film that tends to selectively penetrate D-configuration arginine, and proving that the MCSC / AAO heterostructure nanochannel exhibits a D-configuration chiral helical structure.

[0068] In addition, this embodiment also investigated the chiral sieving performance of MCSC / AAO heterojunction membrane nanochannels and calculated their chiral conversion rate, as detailed below:

[0069] A chiral amino acid solution with a specific concentration and a single configuration, along with deionized water, were added separately to two semi-conductivity cells in a chiral sieving device. The carbon-silicon composite chiral mesoporous nanocomposite material of the MCSC / AAO heterojunction nanochannel was directly contacted with the arginine solution, and the anodic alumina array of the MCSC / AAO heterojunction nanochannel was directly contacted with deionized water. After standing for 24 hours, the deionized water was removed and added to a 1 ml cuvette. The chiral sieving performance was measured using a circular dichroism chromatograph. In this embodiment, the chiral sieving performance of the MCSC / AAO heterojunction nanochannel at a concentration of 10 was tested using a circular dichroism chromatograph. -3 The chiral sieving properties of L-arginine in M, and its effect on a concentration of 10 -3 The chiral sieving properties of M-type D-arginine are shown in the following results. Figure 8 As shown.

[0070] Figure 8 The chiral sieving results of MCSC / AAO heterojunction membrane nanochannels obtained in the embodiments of the present invention. Figure 1 .

[0071] like Figure 8 As shown, data analysis reveals that the MCSC / AAO heterostructured membrane nanochannels can selectively pass through D-configuration arginine, exhibiting excellent chiral sieving performance under concentration-driven and nano-confined adsorption coupling conditions.

[0072] In this embodiment, an equal volume of a solution with a concentration of 10 is added to one of the two half-conductivity cells of the chiral sieving device. -3 Two arginine configurations (L-type and D-type) were prepared in a semi-conductivity cell. Deionized water was added to the cell. A carbon-silicon composite chiral mesoporous nanocomposite material of MCSC / AAO heterostructured nanochannels was directly contacted with the arginine solution, and an anodic alumina array of MCSC / AAO heterostructured nanochannels was directly contacted with the deionized water. After standing for 24 hours, the two arginine configurations were chirally sieved using the concentration gradient across the MCSC / AAO heterostructured nanochannels, and the chiral sieving rate was calculated. The results are as follows: Figure 9 As shown.

[0073] Figure 9 The chiral sieving results of MCSC / AAO heterostructured membrane nanochannels for two configurations (L-type and D-type) of arginine obtained in the embodiments of the present invention are as follows. Figure 2 .

[0074] like Figure 9As shown, data analysis revealed that the MCSC / AAO heterostructure membrane nanochannels can selectively pass through D-configuration arginine, with a selective throughput exceeding 70%, demonstrating a very high sieving effect.

[0075] The above embodiments are preferred embodiments of the present invention and are not intended to limit the scope of protection of the present invention.

Claims

1. Use of a carbon-silicon composite chiral heterojunction film in chiral molecule / ion sieving, characterized in that: A chiral heterojunction membrane composed of carbon-silicon composite components is used to selectively recognize and sieve chiral molecules or ions using concentration-driven forces. This chiral heterojunction membrane is composed of an anodic alumina array and a carbon-silicon composite chiral mesoporous nanocomposite material. The method for preparing the chiral heterojunction film of the carbon-silicon composite component includes: A chiral mesoporous carbon-silicon composite nanocomposite material was uniformly dispersed in an aqueous solution and added onto an anodic aluminum oxide membrane. After removing the solvent by filtration and drying, a chiral heterojunction membrane of the carbon-silicon composite component was obtained. The preparation method of the carbon-silicon composite chiral mesoporous nanocomposite material includes: Step 1: Disperse or dissolve guanylic acid and potassium chloride in deionized water. Add concentrated hydrochloric acid and 3-aminopropyltriethoxysilane while stirring. Continue stirring and add tetraethyl orthosilicate and soluble phenolic resin dropwise. Stir at room temperature for a period of time. Step 2: Transfer the mixed solution obtained in Step 1 into a hydrothermal reactor and carry out a hydrothermal reaction at 80℃~120℃ for 24h~120h. Then filter and dry to obtain a chiral carbon silicon composite material with a template. Step 3: Add the chiral carbon silicon composite material with the template to a mixed solution of concentrated hydrochloric acid and anhydrous ethanol and heat it. Then filter and dry it to obtain a chiral carbon silicon composite mesoporous material with the template removed from the amino-modified inner surface. Step 4: The chiral carbon-silicon composite mesoporous material obtained in step 3 is calcined in an inert gas at 500℃~1000℃ for 3h~5h to obtain the carbon-silicon composite chiral mesoporous nanocomposite material.

2. The application of the carbon-silicon composite chiral heterojunction film according to claim 1 in chiral molecular / ion sieving, characterized in that: wherein, When selectively recognizing and sieving chiral molecules or ions using the carbon-silicon composite chiral heterostructure membrane, one side of the carbon-silicon composite chiral heterostructure membrane is a solution of equal amounts of racemic chiral molecules or ions, and the other side is deionized water.

3. The application of the carbon-silicon composite chiral heterojunction film according to claim 2 in chiral molecular / ion sieving, characterized in that: in, The anodic aluminum oxide array side of the carbon-silicon composite chiral heterostructure film is deionized water, while the carbon-silicon composite chiral mesoporous nanomaterial side is an equal amount of racemic chiral molecules or ionic solution.

4. The application of the carbon-silicon composite chiral heterojunction film according to claim 1 in chiral molecular / ion sieving, characterized in that: in, When selectively recognizing and sieving chiral molecules or ions using the chiral heterojunction membrane of the carbon-silicon composite component, two semi-conductivity cells are used. The chiral heterojunction membrane of the carbon-silicon composite component is placed between the two semi-conductivity cells. Equal amounts of racemic chiral molecule or ion solution and deionized water are added to the two semi-conductivity cells respectively, and then allowed to stand.

5. The application of the carbon-silicon composite chiral heterojunction film according to claim 4 in chiral molecular / ion sieving, characterized in that: in, The concentration of the equivalent racemic chiral molecule or ion solution is 10 -2 -10 -5 M, The settling time is 12-24 hours.

6. The application of the carbon-silicon composite chiral heterojunction film according to claim 4 in chiral molecular / ion sieving, characterized in that: in, The equal amounts of racemic chiral molecules or ionic solutions include chiral amino acid molecules with different isoelectric points.

7. The application of the carbon-silicon composite chiral heterojunction film according to claim 6 in chiral molecular / ion sieving, characterized in that: in, The chiral amino acids include L-arginine and D-arginine.

8. The application of the carbon-silicon composite chiral heterojunction film according to claim 4 in chiral molecular / ion sieving, characterized in that: in, The carbon-silicon composite chiral heterostructure film is vertically disposed between the two semi-conductive cells, the anodic aluminum oxide array is in direct contact with deionized water, and the carbon-silicon composite chiral mesoporous nanomaterial is in direct contact with an equal amount of racemic chiral molecules or ionic solution.

9. The application of the carbon-silicon composite chiral heterojunction film according to claim 1 in chiral molecular / ion sieving, characterized in that: in, In step 1, the concentrated hydrochloric acid is 37% concentrated hydrochloric acid. The molar ratio of the tetraethyl orthosilicate to the soluble phenolic resin is 1:0.75; the mass-to-volume ratio of the guanylic acid to the 3-aminopropyltriethoxysilane is (0.4-0.7) g:(0.70-1.00) ml; the mass-to-volume ratio of the guanylic acid to the tetraethyl orthosilicate is (0.4-0.7) g:(0.79-1.12) ml; and the mass-to-volume ratio of the guanylic acid to the concentrated hydrochloric acid is (0.4-0.7) g:(0.12-0.26) ml.

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