Method for measuring concentration of optically active substance and apparatus for measuring concentration of optically active substance

By measuring the polarization state of reflected light at the interface between aqueous humor and lens at different angles and wavelengths, and combining it with a two-dimensional sensor to calculate the optical properties, the problem of low measurement accuracy caused by the difference in optical properties between the cornea and aqueous humor was solved, and high-precision glucose concentration measurement was achieved.

CN116056625BActive Publication Date: 2025-10-14FUJIFILM CORP
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Patent Information

Application Number
CN202180058229.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2020-07-31
Filing Date
2021-07-02
Publication Date
2025-10-14
Estimated Expiration
2041-07-02

AI Technical Summary

Technical Problem

In the prior art, when polarized light is irradiated into the aqueous humor of the eye to measure glucose concentration, the difference in optical properties between the cornea and the aqueous humor results in low measurement accuracy, making it impossible to accurately measure the glucose concentration in the aqueous humor.

Method used

Polarized light incident at different angles and wavelengths is used, combined with a two-dimensional sensor to measure the polarization state of reflected light at the interface between aqueous humor and lens. By calculating the optical properties of the cornea and aqueous humor, the glucose concentration in the aqueous humor is measured with high precision.

Benefits of technology

This enables simple and high-precision measurement of glucose concentration in aqueous humor, enabling non-invasive detection of blood sugar levels and improving measurement accuracy.

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Abstract

Provided is a method for measuring the concentration of an optically active substance in aqueous humor and an apparatus for measuring the concentration of an optically active substance, which can measure the concentration of an optically active substance in aqueous humor simply and with high accuracy. The method for measuring the concentration of an optically active substance includes a first step of irradiating incident light, which is polarized light, to the aqueous humor of an eye and measuring the polarization state of reflected light obtained by reflection at the interface between the aqueous humor and the lens, wherein the first incident light is irradiated so that the angle between the normal at the point where the incident light intersects the surface of the lens and the incident light is smaller than the Brewster angle, and the polarization state of the first reflected light is measured; a second step of irradiating second incident light so that the angle of the incident light is equal to or greater than the Brewster angle, and the polarization state of the second reflected light is measured; a third step of calculating the optical rotation of the aqueous humor using the information on the polarization state of the first reflected light and the information on the polarization state of the second reflected light; and a fourth step of calculating the concentration of the optically active substance in the aqueous humor based on the optical rotation of the aqueous humor.
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