A micro-nano robot that targets and dissolves tophi

Abstract

The present invention relates to a micro-nano robot, and more specifically, a micro-nano robot that is targeted to dissolve tophi. The micro-nano robot consists of a head and a tail, and the head and the tail form a rigid-flexible composite structure. The rigid-flexible composite structure is a rigid head and a flexible tail. The rigid head has a plurality of cavities. The cavity is provided with a nano switch and an acidity response module. The flexible tail of the micro-nano robot is a flexible spiral drill structure tail, and the flexible spiral drill structure tail is covered with magnetic particles. The rigid head of the micro-nano robot is an ultrasonic sensitive structure head, that is, the front end of the ultrasonic sensitive structure head is an asymmetric structure. The flexible tail of the micro-nano robot is a flexible spiral drill structure tail. The micro-nano robot can be loaded with a variety of composite drugs for targeted transportation, and the amount of drug release can be regulated in the lesion area, so that tophi can be dissolved accurately and efficiently.

Description

Technical Field

[0001] The present invention relates to a micro-nano robot, and more particularly to a micro-nano robot capable of dissolving tophi in a targeted manner. Background Art

[0002] Currently, the overall prevalence of gout in adults in my country is on the rise. As the prevalence and incidence of gout continue to rise annually, patients with gout and tophi are receiving increasing attention. Gout is a common and frequently occurring disease in endocrinology and metabolic diseases, with frequent recurring attacks. In severe cases, tophi can even form. Tophi can damage bone, leading to joint deformities and dysfunction, and even fractures and tophi rupture and infection, severely impacting patients' work and quality of life. Currently, there are two treatment options for tophi: medication and surgery. However, long-term tophi can lead to localized bone destruction, severe impairment of joint function, and the formation of larger tophi. Medication not only requires a long treatment cycle, but also requires a long-term maintenance of blood uric acid levels below 300 μmol / L to soften and dissolve the tophi. At this point, surgical correction of joint deformities is often necessary. However, surgical treatment is not perfect. Postoperative incision infection is one of the common complications, which not only affects the healing of the wound after surgery, but can also lead to local skin necrosis in severe cases. Moreover, if uric acid is not well controlled after surgery, gout stones will continue to form. Therefore, the repeated growth of gout stones is a major problem that needs to be solved urgently.

[0003] With the development of the emerging discipline of nanotechnology, the introduction of micro-nanorobotics offers new avenues for treating tophi. Micro-nanorobotics, with their advantages of small size, light weight, and high power, hold great promise for biomedical applications. Micro-nanorobotics can be used as carriers for chemical compounds designed to dissolve tophi, delivering the drugs to the affected area and achieving high local concentrations, thus achieving non-invasive tophi dissolution and reducing surgical risks. The key to treating tophi lies in lowering uric acid levels. While traditional uric acid-lowering drugs can gradually soften and eventually dissolve tophi, the process is extremely slow, often requiring six months or even years. Therefore, traditional uric acid-lowering drugs are limited to basic uric acid-lowering treatments. Pegloticase, a novel gout treatment, is a pegylated uric acid-specific enzyme that catalyzes the oxidation of uric acid to allantoin, making it more easily soluble and excreted from the body, thereby reducing gout stones. This is currently a research priority. Summary of the Invention

[0004] In order to overcome the shortcomings of the existing technology, the present invention provides a micro-nano robot that can dissolve tophi in a targeted manner. The beneficial effect is that the micro-nano robot can be loaded with multiple complex drugs for targeted transportation, and the amount of drug release can be regulated in the lesion area, thereby dissolving tophi accurately and efficiently.

[0005] The micro-nano robot consists of a head and a tail, and the head and the tail form a rigid-flexible composite structure.

[0006] As a further optimization of the present invention, the rigid-flexible composite structure comprises a rigid head and a flexible tail.

[0007] As a further optimization of the present invention, the rigid head has a plurality of cavities.

[0008] As a further optimization of the present invention, a nano switch and an acidity response module are provided on the cavity.

[0009] As a further optimization of the present invention, the flexible tail of the micro-nano robot is a flexible spiral drill structure tail, and the flexible spiral drill structure tail is covered with magnetic particles.

[0010] As a further optimization of the present invention, the rigid head of the micro-nano robot is an ultrasonic sensitive structure head, that is, the front end of the ultrasonic sensitive structure head is an asymmetric structure.

[0011] As a further optimization of the present invention, the flexible tail of the micro-nano robot is a flexible spiral drill structure tail; the rigid head of the micro-nano robot is an ultrasonic sensitive structure head, that is, the front end of the ultrasonic sensitive structure head is an asymmetric structure.

[0012] The beneficial effects of the micro-nano robot for targeted dissolution of tophi of the present invention are:

[0013] 1. The micro-nano robot, which targets tophi and dissolves tophi, has multiple cavities and can simultaneously load multiple different drugs to target the lesion area, allowing for personalized dosing regimens for each patient.

[0014] 2. The micro-nano robot cavity that specifically dissolves tophi is equipped with a nano-switch that can regulate the release of the drug according to changes in uric acid in the human body, achieving greater functional efficacy in dissolving tophi;

[0015] 3. The micro-nano robot for targeted dissolution of tophi has a spiral drill structure and an ultrasonic sensitive structure. Under the action of an external magnetic field or ultrasonic field, it can generate vibration to crush the tophi. At the same time, it can adopt multiple working modes to achieve a spiral ultrasonic composite effect, thereby dissolving tophi more efficiently. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The present invention will be further described in detail below with reference to the accompanying drawings and specific implementation methods.

[0017] Figure 1 The overall structure of the micro-nano robot for targeted dissolution of tophi.

[0018] Figure 2It is a micro-nano robot cavity structure for targeted dissolution of tophi.

[0019] In the figure: head 1; tail 2; magnetic particle 3; cavity 4; nano switch 5. DETAILED DESCRIPTION

[0020] like Figure 1 The figure shows a micro-nano robot that dissolves tophi. The robot consists of a head and a tail, which form a rigid-flexible composite structure. This rigid-flexible composite structure allows the robot to deform, allowing it to pass through narrow areas in the human body.

[0021] The rigid-flexible composite structure comprises a rigid head and a flexible tail.

[0022] like Figure 1-2 As shown, the rigid head has multiple cavities. These cavities can be used to load various uric acid-dissolving drugs, such as pegloticase, to locally create high drug concentrations, dissolving tophi. Combination therapy can also be implemented, with personalized dosing regimens tailored to the patient, to maximize the efficacy of the drugs and dissolve tophi. This allows for combined drug therapy and maximized efficacy.

[0023] like Figure 1-2 As shown, the cavity is provided with a nano switch and an acidity response module. The acidity response module can detect changes in uric acid in the human body and release a response signal in time. After receiving the signal, the nano switch can adjust the opening size in time according to the changes in uric acid, thereby regulating the amount of drug released, and maximizing functionality to achieve targeted release and efficient utilization of drugs. The nano switch is a porous switch structure of a drug carrier that can adjust the amount of drug released. When the switch is turned on, the amount of drug released increases, and when the switch is closed, the amount of drug released decreases. It is mainly used to adjust the amount of drug released. The acidity response module is a polymer nanoparticle that responds to pH changes. Its volume and shape will change to adjust the size of the nano switch.

[0024] like Figure 1 As shown, the flexible tail of the micro-nano robot is a flexible auger structure coated with magnetic particles. Under the influence of an external magnetic field, the robot is powered, performing a rotary impact motion similar to a drill bit, effectively breaking up tophi. The magnetic particles are ferroferric oxide particles, which are deposited on the auger structure via vacuum ion sputtering. Under the influence of the rotating magnetic field, the magnetic particles are deflected by the magnetic torque, thereby driving the auger structure's motion.

[0025] like Figure 1As shown, the rigid head of the micro-nano robot is an ultrasonically sensitive structure head, that is, the front end of the ultrasonically sensitive structure head is an asymmetric structure. Under the action of an external ultrasonic field, the robot can generate high-frequency vibrations, thereby achieving efficient crushing of tophi. The ultrasonically sensitive structure means that the head of the micro-nano robot is an asymmetric structure with a concave end. This asymmetric shape will cause an asymmetric distribution of sound pressure caused by the scattering of the incident ultrasonic wave on the surface. The sound wave scattering at the concave end concentrates the energy near the curvature, while other surfaces will weaken the energy near the curvature, thereby generating a local induced pressure gradient, generating power to make it move and achieve vibration.

[0026] Through the flexible spiral drill structure tail and ultrasonic sensitive structure head, the combined effect of high-frequency vibration and spiral drill is achieved. At the same time, it can also cooperate with the effect of drugs to soften and dissolve the crushed tophi, thereby dissolving the tophi efficiently.

Claims

1. A micro-nano robot for targeted dissolution of tophi, characterized by: The micro-nano robot consists of a head and a tail, and the head and the tail form a rigid-flexible composite structure; The rigid-flexible composite structure comprises a rigid head and a flexible tail; The rigid head has a plurality of cavities; The cavity is provided with a nano switch and an acidity response module; The flexible tail of the micro-nano robot is a flexible spiral drill structure tail, and the flexible spiral drill structure tail is covered with magnetic particles; The rigid head of the micro-nano robot is an ultrasonic sensitive structure head, that is, the front end of the ultrasonic sensitive structure head is an asymmetric structure; Nanoswitch is a porous switch structure of drug carrier that regulates the amount of drug release.

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