A method for purifying losartan
By washing the losartan solution with bisulfite or sulfite solution, combined with alkaline aqueous solution treatment, the problems of high cost and waste generation in the removal of color impurities in losartan production are solved, achieving efficient and environmentally friendly losartan purification, and improving the appearance quality and yield of the drug.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ZHEJIANG HUAHAI PHARMACEUTICAL CO LTD
- Filing Date
- 2022-01-04
- Publication Date
- 2026-07-17
AI Technical Summary
The existing methods for removing color impurities in the production process of losartan are costly, pose significant safety risks, and generate a large amount of waste, affecting the appearance and sensory effects of the drug.
The losartan solution is washed with bisulfite or sulfite solution, followed by alkaline aqueous solution treatment, and then washed with bisulfite or sulfite solution. After separation and acidification, the number of times activated carbon is used and the decolorization steps are reduced, thereby improving the purification efficiency.
It effectively removes color impurities, reduces the amount of activated carbon used and the number of decolorization cycles, reduces material loss, saves manpower and resources, and improves the purity and yield of losartan.
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