Animal liver tumor tissue extraction device

Abstract

The application provides an animal liver tumor tissue extraction device, which comprises a sampling cylinder with a blade part at the front end and a diameter adjustable by metal band curling, and a suction device for sucking liver tumor tissue, a cutting part is fixed to the inner wall of the front end of the sampling cylinder and used for cutting the liver tumor tissue circled by the sampling cylinder, and the rear end port of the sampling cylinder is connected with the inlet of the suction device through an intermediate flexible ring. The sampling cylinder is used for circling the liver tumor tissue, the cutting part is used for cutting the liver tumor tissue, and the suction device is used for sucking the liver tumor tissue to complete sampling. Moreover, the diameter of the sampling cylinder is adjustable, the flexible ring changes its own form to adapt to the variable diameter of the sampling cylinder, and an operator can adjust the diameter of the sampling cylinder according to the size of the liver tumor tissue of an animal, so that liver tumor tissues with different sizes can be extracted, and actual demands can be met.

Description

Technical Field

[0001] This invention belongs to the field of animal tumor tissue extraction, specifically relating to an animal liver tumor tissue extraction device. Background Technology

[0002] With changes in people's lifestyles, the progress of social industrialization, and increased life expectancy, the incidence of cancer has also increased, becoming one of the main threats to human life and health. Liver cancer, known as the "king of cancers," is a key disease for prevention and treatment in my country. However, its causes are numerous, its process is complex, its cure rate is poor, and its mechanisms are still unclear, requiring further in-depth elucidation.

[0003] Mice are typical animal models of human diseases. When sampling liver tumor tissue in mice, scissors or forceps are commonly used. The extracted tissue has poor morphology and may contain some normal tissue other than tumor tissue, which is not conducive to later research. CN201821018339.4 discloses a sampling device for rat liver tissue, which samples through a needle at the front end of the sampling tube. Although it can accurately extract liver tumor tissue, it cannot extract liver tumor tissue of different sizes according to actual needs. Summary of the Invention

[0004] The present invention aims to solve the technical problems existing in the prior art, and the purpose of the present invention is to provide an animal liver tumor tissue extraction device.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: an animal liver tumor tissue extraction device, comprising a sampling cylinder with an adjustable diameter and a blade at the front end formed by rolling a metal strip, and an aspirator for aspirating liver tumor tissue. The aspirator has an aspiration chamber for accommodating the aspirated liver tumor tissue. A cutting element for cutting the liver tumor tissue enclosed by the sampling cylinder is fixedly attached to the inner wall at the front end of the sampling cylinder. The rear port of the sampling cylinder is connected to the inlet of the aspirator through an intermediate flexible ring.

[0006] In the above technical solution, the sampling tube is used to delineate the liver tumor tissue, the cutting component is used to cut the liver tumor tissue, and the aspirator is used to extract the liver tumor tissue to complete the sampling. Moreover, the diameter of the sampling tube is adjustable, and the operator can adjust the diameter of the sampling tube according to the size of the animal's liver tumor tissue to extract liver tumor tissue of different sizes to meet actual needs. Furthermore, the flexible ring is used to connect the sampling tube outlet and the aspirator inlet. When adjusting the size of the sampling tube, the flexible ring changes its shape to adapt to the variable diameter of the sampling tube, ensuring that the connected sampling tube outlet and aspirator inlet can always be sealed.

[0007] In a preferred embodiment of the present invention, the two ends of the metal strip overlap to form two overlapping sections, namely an outer overlapping section and an inner overlapping section. At least one circumferentially spaced limiting ring is fixed to the outer wall of the sampling tube, and the outer overlapping section can pass through the limiting ring and overlap outside the inner overlapping section.

[0008] In the above technical solution, the diameter of the sampling tube can be adjusted by the relative circumferential movement of the inner and outer overlapping sections, and the adjustment method is simple; moreover, the limiting ring restricts the outer overlapping section, so that the outer overlapping section can always be tightly attached to the inner overlapping section, without hindering the insertion of the sampling tube into the animal's liver.

[0009] In a preferred embodiment of the present invention, a first operating rod extending along the rear side of the sampling cylinder is fixedly connected to the outer overlapping section, and a second operating rod extending along the rear side of the sampling cylinder is fixedly connected to the inner overlapping section.

[0010] In the above technical solution, by setting a first operating lever and a second operating lever, the diameter of the sampling cylinder can be adjusted by moving the first operating lever and the second operating lever closer to each other or further apart, making the operation more convenient.

[0011] In a preferred embodiment of the present invention, the outer wall of the suction device has a first groove and a second groove extending circumferentially, the first operating rod has a slide post that can be engaged in and slide in the first groove, and the second operating rod also has a slide post that can be engaged in and slide in the second groove.

[0012] In the above technical solution, the first sliding groove and the sliding column cooperate to guide the circumferential sliding of the first operating rod, and the second sliding groove and the sliding column cooperate to guide the circumferential sliding of the second operating rod, making it more convenient to slide the first and second operating rods circumferentially.

[0013] In a preferred embodiment of the present invention, the sampling cylinder and the suction device are also connected by a support frame to achieve axial fixation between the two.

[0014] In the above technical solution, after setting up the support frame, the operator can insert the sampling tube into the animal liver by holding the suction device, and use the suction device as the handle of the entire extraction device.

[0015] In another preferred embodiment of the present invention, the cutting element is a steel needle with blades on both the left and right sides. By rotating the sampling cylinder, the steel needle can cover the area enclosed by the sampling cylinder.

[0016] In the above technical solution, the cutting component is a steel needle, which is small in size and does not hinder the insertion of the sampling tube into the animal's liver.

[0017] In another preferred embodiment of the present invention, one end of the steel needle is fixedly connected to the inner wall of the sampling cylinder, and the other end of the steel needle has a gap with the inner wall of the sampling cylinder.

[0018] The above technical solution ensures that the steel needle will not split the liver tumor tissue in two when the sampling tube is inserted.

[0019] In another preferred embodiment of the present invention, the aspirator includes an aspirator tube whose front end is connected to and communicates with the rear end of the flexible ring. The diameter of the aspirator tube is larger than that of the sampling tube. A piston is slidably connected inside the aspirator tube. The space between the piston and the front part of the aspirator tube is an aspirator cavity. A piston rod is fixedly connected to the rear end of the piston.

[0020] In the above technical solution, the piston can be moved backward by pulling the piston rod, which can then be used to suction out the tumor tissue in the animal's liver, making the operation convenient.

[0021] In another preferred embodiment of the present invention, the outer wall of the sampling tube has a depth scale line for measuring the insertion depth of the sampling tube; and / or the outer wall of the sampling tube has a diameter scale line arranged circumferentially thereon for measuring the diameter of the sampling tube.

[0022] In the above technical solution, by setting depth and diameter scale lines, operators can easily adjust the diameter of the sampling tube and the depth of insertion into the mouse liver according to the size of the animal's liver tumor tissue, so as to completely remove the animal's liver tumor tissue.

[0023] In another preferred embodiment of the present invention, a suction device is further included. The suction device is connected to and communicates with the suction chamber of the aspirator. A camera capable of capturing depth and diameter scale lines is detachably connected to the outer wall of the aspirator. The signal output terminal of the camera is connected to a controller with a display device. The controller calculates the suction force based on the depth and diameter of the liver tumor tissue and controls the suction device to perform suction. The suction force is:

[0024]

[0025] Where P is the suction force of the suction device, R is the radius of the extracted liver tumor tissue, L is the depth of the extracted liver tumor tissue, η is the viscosity of the liver tumor tissue, l is the length of the suction chamber of the suction device, t is the suction time of the liver tumor tissue, and r is the radius of the suction chamber of the suction device.

[0026] In the above technical solution, a camera is set up to collect information, which is then transmitted to the controller and displayed on the display device. This allows medical staff to more intuitively read the diameter and insertion depth of the sampling tube from the display device. By setting up a suction device connected to the suction chamber, the liver tumor tissue of the animal can be automatically aspirated. By controlling the suction force of the suction device, the liver tumor tissue of the animal can be completely aspirated. In particular, for some large animals (such as rabbits and small monkeys), whose liver tumor tissue is relatively large, the tissue can be aspirated repeatedly by the suction device to remove the tissue.

[0027] Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0028] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0029] Figure 1 This is a schematic diagram of the main cross-sectional structure of an animal liver tumor tissue extraction device according to Embodiment 1 of this application.

[0030] Figure 2 yes Figure 1 A rear view of the sampling cylinder.

[0031] Figure 3 yes Figure 2 View A in the diagram.

[0032] Figure 4 This is a schematic diagram of the metal strip in Example 1.

[0033] Figure 5 This is a schematic diagram of the main cross-sectional structure of an animal liver tumor tissue extraction device according to Embodiment 2 of this application.

[0034] The reference numerals in the accompanying drawings include: sampling cylinder 10, metal strip 11, bevel 111, outer overlapping section 12, inner overlapping section 13, limiting ring 14, first operating lever 15, sliding column 151, second operating lever 16, cutting piece 20, flexible ring 30, suction device 40, first sliding groove 401, suction cylinder 41, guide port 411, connecting port 412, piston 42, piston rod 43, suction chamber 44, and suction device 50. Detailed Implementation

[0035] Embodiments of the present invention are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0036] In the description of this invention, it should be understood that the terms "longitudinal", "lateral", "vertical", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", and "outer" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0037] Example 1

[0038] This embodiment provides an animal liver tumor tissue extraction device. The aforementioned animal usually refers to a mouse or rat, but it can also be used in experiments with larger animals such as rabbits and monkeys.

[0039] like Figure 1 and Figure 4 As shown, in a preferred embodiment, the extraction device includes a sampling cylinder 10 with an adjustable diameter formed by coiling a metal strip 11, and an aspirator 40 for aspirating liver tumor tissue. Preferably, the metal strip 11 is made of spring steel. The front end of the sampling cylinder 10 has a blade for easy insertion into the animal's liver. The aspirator 40 has an aspiration cavity 44 for accommodating the aspirated liver tumor tissue. The aspirator 40 is structurally connected to a syringe, and the aspirator 40 aspirates the liver tumor tissue using negative pressure. A cutting element 20 for cutting the liver tumor tissue encircled by the sampling cylinder 10 is fixed to the inner wall of the front end of the sampling cylinder 10. The rear end of the sampling cylinder 10 is connected to the inlet of the aspirator 40 via an intermediate flexible ring 30.

[0040] The cutting element 20 is a steel needle with blades on both sides. By rotating the sampling cylinder 10, the steel needle can cover the area enclosed by the sampling cylinder 10, so as to cut and separate the liver tumor tissue enclosed by the sampling cylinder 10 from the liver. One end of the steel needle is fixed to the inner wall of the sampling cylinder 10, and there is a gap between the other end of the steel needle and the inner wall of the sampling cylinder 10, ensuring that the steel needle will not split the liver tumor tissue in two when inserted into the sampling cylinder 10. The flexible ring 30 is made of medical rubber, medical silicone, or medical film. When the size of the sampling cylinder 10 is adjusted, the flexible ring 30 changes its shape to adapt to the variable diameter of the sampling cylinder 10, so that the inlet of the aspirator 40 can communicate with the inside of the sampling cylinder 10 to aspirate the liver tumor tissue.

[0041] Using this technical solution, the operator first adjusts the diameter of the sampling cylinder 10 according to the size of the liver tumor tissue in the animal, ensuring that the diameter of the sampling cylinder 10 is compatible with the size of the liver tumor tissue. Then, the sampling cylinder 10 is inserted into the animal's liver, so that the liver tumor tissue is located in the sampling cylinder 10. Then, by rotating the sampling cylinder 10 (one to two rotations are sufficient), the liver tumor tissue is cut off by the cutting piece 20 at the front end of the sampling cylinder 10. Afterwards, the liver tumor tissue is aspirated into the aspirator 40, thus completing the sampling process.

[0042] In this invention, the aspirator 40 includes an aspiration cylinder 41 whose front end is connected to and communicates with the rear end of the flexible ring 30. The diameter of the aspiration cylinder 41 is larger than that of the sampling cylinder 10. A piston 42 is slidably connected inside the aspiration cylinder 41. The space between the piston 42 and the front part of the aspiration cylinder 41 is an aspiration chamber 44. The outer wall of the piston 42 is sealed to the inner wall of the aspiration cylinder 41. A piston rod 43 is fixedly connected to the rear end of the piston 42. To facilitate the aspiration of liver tumor tissue into the aspiration cylinder 41, the front end of the inner wall of the aspiration cylinder 41 has a guide port 411 that smoothly transitions with the flexible ring 30. The front end of the guide port 411 is larger than its rear end. After sampling, the liver tumor tissue of the animal can be obtained from the aspiration cylinder 41 by pulling out the piston rod 43 and the piston 42.

[0043] In another preferred embodiment, the flexible ring 30 is detachably and sealed to the suction cylinder 41. For example, the front end of the suction device 40 has a constricted connection port 412, and the flexible ring 30 is sleeved on the connection port 412 and tightly fitted thereto. After sampling, the connection between the flexible ring 30 and the suction cylinder 41 can be disconnected, allowing the piston rod 43 to move forward and push the liver tumor tissue out from the front end of the suction cylinder 41, thereby obtaining the animal's liver tumor tissue.

[0044] like Figure 1 and Figure 2 As shown, in this invention, the two ends of the metal strip 11 overlap to form two overlapping sections, namely an outer overlapping section 12 and an inner overlapping section 13. At least one circumferentially spaced limiting ring 14 is fixed to the outer wall of the sampling cylinder 10. For example, two limiting rings 14 are circumferentially spaced on the outer wall of the inner overlapping section 13. The outer overlapping section 12 can pass through the limiting ring 14 and overlap the inner overlapping section 13. The limiting ring 14 is a thin-walled part, and the limiting ring 14 also has a blade near the front end of the sampling cylinder 10, so as not to hinder the insertion of the sampling cylinder 10 into the animal liver.

[0045] like Figure 3 and Figure 4 As shown, in this embodiment, in order to facilitate the outer overlapping section 12 passing through the limiting ring 14 and overlapping the inner overlapping section 13, the two side walls of the outer overlapping section 12 of the metal strip 11 can be set as inclined sides 111, so that the width of the outer overlapping section 12 is slightly smaller than the width of the inner overlapping section 13.

[0046] like Figures 1-3 As shown, in another preferred embodiment of the present invention, a first operating rod 15 extending along the rear side of the sampling cylinder 10 is fixedly connected to the rear end of the outer overlapping section 12, and a second operating rod 16 extending along the rear side of the sampling cylinder 10 is fixedly connected to the rear end of the inner overlapping section 13. The first operating rod 15 and the second operating rod 16 are arranged parallel to each other. This allows the diameter of the sampling cylinder 10 to be adjusted by moving the first operating rod 15 and the second operating rod 16 closer to or further away from each other, making operation more convenient.

[0047] More preferably, the outer wall of the suction cylinder 41 of the suction device 40 has a first groove 401 and a second groove extending circumferentially. The first operating rod 15 has a sliding post 151 that can be engaged in and slide in the first groove 401, and the second operating rod 16 also has a sliding post 151 that can be engaged in and slide in the second groove. Preferably, two first grooves 401 and two grooves are provided at intervals along the length direction of the suction cylinder 41. The first groove 401 cooperates with the sliding post 151 of the first operating rod 15 to guide the circumferential sliding of the first operating rod 15, and the second groove cooperates with the sliding post 151 of the second operating rod 16 to guide the circumferential sliding of the second operating rod 16, making it more convenient to slide the first operating rod 15 and the second operating rod 16 circumferentially.

[0048] In another preferred embodiment of the present invention, the sampling cylinder 10 and the suction cylinder 41 of the aspirator 40 are also connected by a support frame to achieve axial fixation between the two. The support frame can be the aforementioned first operating rod 15 and second operating rod 16, or multiple connecting rods can be provided between the sampling cylinder 10 and the suction cylinder 41 as a support frame. This allows the sampling cylinder 10 to be made shorter, and the sampling cylinder 10 can be inserted into the animal liver by holding the suction cylinder 41 of the aspirator 40, with the suction cylinder 41 serving as the handle of the entire extraction device.

[0049] In another preferred embodiment of the invention, the outer wall of the sampling cylinder 10 has depth graduations for measuring the insertion depth of the sampling cylinder 10. This allows the operator to adjust the insertion depth into the animal's liver according to the depth of the liver tumor tissue, ensuring complete removal of the tumor tissue.

[0050] In another preferred embodiment of the present invention, the outer wall of the sampling cylinder 10 has diameter graduations arranged circumferentially for measuring the diameter of the sampling cylinder 10. Specifically, a length mark can be first set along the length direction of the metal strip 11, and then the diameter d of the sampling cylinder 10 can be obtained using the circumference formula L = πd. By setting the diameter graduations, it is convenient for the operator to adjust the diameter of the sampling cylinder 10 according to the size of the liver tumor tissue in the animal.

[0051] Example 2

[0052] This embodiment is basically the same in structure and principle as Embodiment 1, the difference being that, Figure 5 As shown, in this embodiment, the animal liver tumor tissue extraction device further includes a suction device 50, which is connected to and communicates with the suction chamber 44 of the aspirator 40. The suction device 50 is a suction pump that communicates with the side wall of the suction chamber 44 via a trachea, and the power of the suction pump is adjustable. A camera (not shown in the figure) capable of capturing depth and diameter scale lines can also be detachably connected to the outer wall of the aspirator 40. For example, the camera can be clipped and fixed to the outer wall of the aspirator 40, and the signal output terminal of the camera is connected to a controller with a display device. The controller calculates the suction force based on the depth and diameter of the liver tumor tissue and controls the suction device to perform suction. The suction force is:

[0053]

[0054] Wherein, P is the suction force of the suction device 50, R is the radius of the extracted liver tumor tissue, L is the depth of the extracted liver tumor tissue, η is the viscosity of the liver tumor tissue (which can be determined using existing liver tissue viscosity acquisition methods or ultrasound detection systems), l is the length of the suction chamber 44 of the aspirator, t is the suction time of the liver tumor tissue, and r is the radius of the suction chamber 44 of the aspirator.

[0055] This embodiment uses a camera to collect information, which is then transmitted to the controller and displayed on a display device. This allows medical personnel to more intuitively read the diameter and insertion depth of the sampling tube from the display device. Initially, the piston rod 43 is pulled back to ensure that the suction chamber 44 has a sufficiently large space to accommodate the liver tumor tissue. After the cutting piece 20 cuts off the liver tumor tissue, the suction device 50 is activated. The suction device 50 generates negative pressure to draw the liver tumor tissue separated from the animal liver into the suction chamber 44 through the sampling tube 10 and the flexible ring 30, thus achieving automatic extraction of the liver tumor tissue.

[0056] In the description of this specification, references to terms such as "preferred embodiment," "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0057] Although embodiments of the invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims

1. An animal liver tumor tissue extraction device, characterized in that, The sample tube, which is formed by rolling a metal strip, has an adjustable diameter and a blade at the front end, and an aspirator for aspirating liver tumor tissue. The aspirator has an aspiration chamber for accommodating the aspirated liver tumor tissue. A cutting element for cutting the liver tumor tissue enclosed by the sample tube is fixed to the inner wall at the front end of the sample tube. The rear end of the sample tube is connected to the inlet of the aspirator through an intermediate flexible ring. The outer wall of the sampling tube has depth scale lines along its length for measuring the insertion depth of the sampling tube; the outer wall of the sampling tube has diameter scale lines along its circumference for measuring the diameter of the sampling tube. The animal liver tumor tissue extraction device also includes a suction device, which is connected to and communicates with the suction chamber of the aspirator. A camera capable of capturing images of the depth and diameter scale lines is detachably connected to the outer wall of the aspirator. The camera's signal output is connected to a controller with a display device. The controller calculates the suction force based on the depth and diameter of the liver tumor tissue and controls the suction device to perform suction. The suction force is: Where P is the suction force of the suction device, R is the radius of the extracted liver tumor tissue, L is the depth of the extracted liver tumor tissue, η is the viscosity of the liver tumor tissue, l is the length of the suction chamber of the suction device, t is the suction time of the liver tumor tissue, and r is the radius of the suction chamber of the suction device.

2. The animal liver tumor tissue extraction device according to claim 1, characterized in that, The two ends of the metal strip overlap to form two overlapping sections, namely an outer overlapping section and an inner overlapping section. At least one circumferentially spaced limiting ring is fixed to the outer wall of the sampling tube, and the outer overlapping section can pass through the limiting ring and overlap the inner overlapping section.

3. The animal liver tumor tissue extraction device according to claim 2, characterized in that, A first operating rod extending along the rear side of the sampling cylinder is fixedly connected to the outer overlapping section, and a second operating rod extending along the rear side of the sampling cylinder is fixedly connected to the inner overlapping section.

4. The animal liver tumor tissue extraction device according to claim 3, characterized in that, The outer wall of the suction device has a first and a second circumferentially extending groove. The first operating rod has a sliding post that can be engaged in and slide in the first groove, and the second operating rod also has a sliding post that can be engaged in and slide in the second groove.

5. The animal liver tumor tissue extraction device according to claim 1, characterized in that, The sampling tube and the aspirator are also connected by a support frame to achieve axial fixation between the two.

6. An animal liver tumor tissue extraction device according to any one of claims 1-5, characterized in that, The cutting component is a steel needle with blades on both the left and right sides. By rotating the sampling cylinder, the steel needle can cover the area enclosed by the sampling cylinder.

7. The animal liver tumor tissue extraction device according to claim 6, characterized in that, One end of the steel needle is fixed to the inner wall of the sampling cylinder, and there is a gap between the other end of the steel needle and the inner wall of the sampling cylinder.

8. An animal liver tumor tissue extraction device according to any one of claims 1-5, characterized in that, The aspirator includes an aspirator tube whose front end is connected to and communicates with the rear end of the flexible ring. The diameter of the aspirator tube is larger than that of the sampling tube. A piston is slidably connected inside the aspirator tube. The space between the piston and the front part of the aspirator tube is the aspirator cavity. A piston rod is fixedly connected to the rear end of the piston.

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