Parenteral nutrition solution proportioning and delivery device

Abstract

This invention discloses a parenteral nutrition solution preparation and delivery device, comprising a first mixing component, a second mixing component, a third mixing component, a secondary mixing chamber, a transfer chamber, a tertiary mixing chamber, and a frame. The first mixing component mixes phosphate-free electrolytes, water-soluble vitamins, and trace elements into a compound amino acid solution. The second mixing component mixes phosphates into a glucose solution. The third mixing component mixes fat-soluble vitamins into a fat emulsion. The secondary mixing chamber further mixes the mixed amino acid solution and the mixed glucose solution. The transfer chamber agitates the mixed solution to ensure thorough mixing. The tertiary mixing chamber adds the fat emulsion containing fat-soluble and water-soluble vitamins to the amino acid and glucose mixture. This device, through the coordinated operation of its components, enables the rapid and accurate preparation of large quantities of parenteral nutrition solution, and the preparation process is carried out within a sealed container, preventing contamination of the nutrient solution by the external environment.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical machinery, in particular to an external nutrition solution proportioning and conveying device. BACKGROUND

[0002] Parenteral nutrition is to supply nutrition from intravenous as preoperative and postoperative nutrition support for critically ill patients, and all nutrition is supplied from the outside of the intestine, which is called total parenteral nutrition. The elements constituting parenteral nutrition include heat (carbohydrate, fat emulsion), essential and non-essential amino acids, vitamins, electrolytes and trace elements. The proportion of parenteral nutrition solution is related to whether the patient can maintain the nutritional status, weight gain and wound healing. The traditional manual configuration of parenteral nutrition solution is inefficient, the proportion of each part of the substance is not accurate, and the manually configured nutrition solution cannot be isolated from the external environment and is easy to be contaminated. On the other hand, the oil droplets contained in the internal fat emulsion of the traditional nutrition solution are easy to stratify with other substances after long time standing, so that the oil droplets all converge in the uppermost layer, thereby causing the nutrition solution to be invalid. In order to mix the mixed solution thoroughly, the fat emulsion and other solutions are often vibrated, which is easy to cause the oil droplets in the fat emulsion to collide with each other and produce larger oil droplets, and the large oil droplets are easy to block the capillary blood vessels of the patient and cause danger. SUMMARY

[0003] The present application aims to provide a kind of, to solve the problems raised in the above background.

[0004] In order to solve the above technical problems, the present application provides the following technical solutions: an external nutrition solution proportioning and conveying device, comprising a first mixing assembly, a second mixing assembly, a third mixing assembly, a secondary mixing cavity, a transfer cavity, a tertiary mixing cavity and a rack, the rack comprising a first layer plate, a second layer plate, a third layer plate, a fourth layer plate and a fifth layer plate, the first layer plate being at the bottom, the fifth layer plate being at the top, the second layer plate, the third layer plate and the fourth layer plate being arranged in order from bottom to top, support columns being installed between each layer plate, the first mixing assembly and the second mixing assembly being connected to the top side of the fifth layer plate, the first mixing assembly and the second mixing assembly being fastened to the fourth layer plate at the middle position, the first mixing assembly and the second mixing assembly being fastened to the third layer plate at the bottom side, the first mixing assembly and the second mixing assembly being connected to the top of the secondary mixing cavity through a transfusion pipeline, the secondary mixing cavity and the transfer cavity being fastened to the second layer plate at the bottom, the secondary mixing cavity being connected to the transfer cavity through a transfusion pipeline, the transfer cavity being connected to the tertiary mixing cavity through a transfusion pipeline, the third mixing assembly being installed above the third layer plate and below the second layer plate, the third mixing assembly being connected to the tertiary mixing cavity through a pipeline, and the tertiary mixing cavity being installed on the first layer plate. The first mixing assembly mixes electrolytes without phosphates, water-soluble vitamins and trace elements into compound amino acids, the second mixing assembly mixes phosphates into glucose solution, and the third mixing assembly mixes fat-soluble vitamins into fat milk. The secondary mixing cavity mixes the mixed amino acid solution and the mixed glucose solution, the transfer cavity overturns the mixed solution to fully mix it, and the tertiary mixing cavity adds fat milk mixed with fat-soluble vitamins and water-soluble vitamins into the mixed amino acid and glucose solution. The device realizes rapid and accurate proportioning of a large amount of external nutrition solution through cooperation of each assembly, and the proportioning process is carried out in a sealed container, preventing pollution of the external environment to the nutrition solution. The tertiary mixing cavity of the present application also generates a reverse electric field through a spiral coil, increasing the downward force on the oil phase in the fat milk, and avoiding the separation of the fat milk after long-term standing.

[0005] Further, the first mixing assembly comprises an amino acid solution cavity, a first primary mixing cavity and a first concentrated solution injector, the amino acid solution cavity is fixedly connected with the five-layer plate, the bottom of the amino acid solution cavity is connected with the infusion pipeline and the bottom of the sidewall of the first primary mixing cavity, the middle position of the first primary mixing cavity is fixedly connected with the four-layer plate, the bottom of the first primary mixing cavity is fixedly connected with the three-layer plate, and the first concentrated solution injector is connected with the bottom of the sidewall of the first primary mixing cavity. Before the preparation of the primary mixed solution, the required electrolyte without phosphate, water-soluble vitamins, trace elements and a small amount of amino acid solution are mixed to prepare a concentrated solution according to the preparation dose, the concentrated solution is sucked into the first concentrated solution injector, the first concentrated solution injector is inserted into the injector input port, when the first primary mixing cavity starts to work, the electric cylinder drives the piston to move upwards, in the closed space, the upward movement of the piston generates suction to suck the liquid in the amino acid solution cavity and the liquid in the first concentrated solution injector into the primary mixing cavity. Since the amount of the concentrated solution is much less than the amount of the amino acid solution, the concentrated solution will be completely sucked in, the concentrated solution is diluted by the amino acid solution, the total amount of the mixed solution is controlled by the contraction size of the electric cylinder, and the standard preparation amount can be accurately achieved, the preparation process is isolated from the outside air, and the influence of external pollutants and gases on the mixed solution is effectively prevented.

[0006] Further, the first primary mixing cavity comprises an electric cylinder, a primary mixing cavity body, a vane, an inner piston ring, an outer piston ring, an inner bottom plate, an outer bottom plate, a screw rod nut mounting plate, a screw rod, and a screw rod nut. The inner wall bottom side of the primary mixing cavity body is fixedly connected to the outer side of the outer bottom plate. The bottom of the outer bottom plate is fixedly connected to the four-layer plate. The electric cylinder is mounted on the top of the primary mixing cavity body, and the guide rod of the electric cylinder extends into the primary mixing cavity body. The guide rod of the electric cylinder is fixedly connected to the inner piston ring through a mounting seat. The inner piston ring is rotatably connected to the outer piston ring. The outer piston ring can axially and sealingly slide in the inner wall of the primary mixing cavity body. The inner bottom plate is rotatably connected to the outer bottom plate. The top of the vane is fixedly connected to the bottom of the outer piston ring. The bottom of the vane is fixedly connected to the top of the screw rod nut mounting plate. The middle part of the vane passes through the inner bottom plate. The part of the vane passing through the inner bottom plate is sealingly connected to the inner bottom plate. The screw rod nut is fixedly connected to the screw rod nut mounting plate. The bottom of the screw rod is fixedly connected to the three-layer plate. The top of the screw rod is rotatably connected to the inner bottom plate through a bearing. The screw rod passes through the screw rod nut. The electric cylinder drives the inner piston ring to move upward, and the inner piston ring drives the outer piston ring to move upward. When the inner piston ring and the outer piston ring move upward as a whole, a suction force is generated in the sealing cavity. The suction force is used to suck the solution into the primary mixing cavity. When the outer piston ring moves upward, the vane connected to the outer piston ring drives the screw rod nut mounting plate to move upward. When the screw rod nut mounting plate moves upward, the screw rod nut and the screw rod are relatively displaced. Since the screw rod is fixed, the screw rod nut rotates. The screw rod nut drives the screw rod nut mounting plate to rotate. The screw rod nut mounting plate drives the vane to rotate. The rotation of the vane uniformly mixes the concentrated solution and the amino acid solution. The device uses the lifting of the electric cylinder to drive the rotation of the vane, which reduces one motor for driving the rotation of the vane and reduces the cost of the device.

[0007] Further, the bottom of the side wall of the primary mixing cavity is provided with a solution inlet and a syringe input port. Check valves are mounted on the solution inlet and the syringe input port. The check valves allow the inlet but not the outlet. The solution inlet is connected to the amino acid solution cavity through a solution pipeline. The syringe input port is connected to the first concentrated solution syringe. The outer bottom plate is provided with a solution outlet. A check valve is mounted on the solution outlet. The check valve allows the outlet but not the inlet. The solution outlet is connected to the top of the secondary mixing cavity through a solution pipeline. The check valve of the solution outlet ensures that the solution outlet remains closed when liquid is sucked in. The check valves of the solution inlet and the syringe input port ensure that when the solution is discharged from the primary mixing cavity, it only flows out from the solution outlet and does not backflow from the solution inlet and the syringe input port.

[0008] Further, the second mixing assembly comprises a glucose solution cavity, a second primary mixing cavity and a second concentrated solution injector, the glucose solution cavity is fixedly connected with the five-layer board, the bottom of the glucose solution cavity is connected with the bottom of the side wall of the second primary mixing cavity through a transfusion pipeline, the middle of the second primary mixing cavity is fixedly connected with the four-layer board, the bottom of the second primary mixing cavity is fixedly connected with the three-layer board, the second concentrated solution injector is connected with the bottom of the side wall of the second primary mixing cavity, the second primary mixing cavity is the same as the first primary mixing cavity in structure except that the mixed solution is different. The mixed substance in the second concentrated solution injector is phosphate, and the phosphate is mixed into the glucose solution alone because the phosphate will cause calcium phosphate precipitation with calcium in the amino acid substance, and the precipitated substance will block the microvessels in the lung. However, if the phosphate is dissolved in the glucose solution and then the glucose solution and the amino acid solution are mixed, the problem will not occur.

[0009] Further, the transfer cavity comprises a transfer cylinder, a transfer piston, a transfer cavity body, an inlet and an outlet, the bottom of the transfer cavity body is fixedly connected with the two-layer board, the transfer cylinder is installed on the top of the transfer cavity body, a guide rod of the transfer cylinder extends into the inside of the transfer cavity body, the front end of the guide rod is fixedly connected with the transfer piston, the transfer piston can axially and sealingly slide on the inner wall of the transfer cavity body, the inlet and the outlet are installed on the two sides of the bottom of the side wall of the transfer cavity body, the inlet and the outlet are both provided with check valves, the check valve of the inlet can only enter but not exit, and the check valve of the outlet can only exit but not enter, the inlet is connected with the bottom of the second mixing cavity through a transfusion pipeline, and the outlet is connected with the third mixing cavity through a transfusion pipeline. The mixed solution is sucked into the transfer cavity from the inlet at the bottom of the side of the transfer cavity body, the solution originally at the bottom goes to the top, which is equivalent to inverting the solution, and the two different solutions are mixed more uniformly after being inverted. After the solution is mixed, the transfer cylinder is pressed downward to drive the transfer piston to be pressed downward, and the mixed solution is pressed and sent from the outlet to the third mixing cavity.

[0010] Furthermore, the third mixing assembly includes a fat emulsion chamber, a third primary mixing chamber, and a third concentrated solution injector. The third primary mixing chamber includes a fat emulsion mixing body, a mixing cylinder, a mixing piston, a fat solution outlet, and a fat emulsion inlet. The fat emulsion chamber is mounted on a three-layer plate. The bottom of the fat emulsion chamber is connected to the fat emulsion inlet via an infusion pipe. The fat emulsion inlet has a one-way valve inside, which allows inflow but not outflow. An injection port is opened on the side of the fat emulsion inlet, and the third concentrated solution injector is inserted into this injection port. The fat solution outlet is mounted on the bottom of the fat emulsion mixing chamber and is equipped with a one-way valve, which allows outflow but not inflow. The fat solution outlet is connected to the third primary mixing chamber via an infusion conduit. The mixing cylinder is mounted on the top of the fat emulsion mixing chamber, and the mixing cylinder guide rod extends into the fat emulsion mixing chamber. The mixing piston and the front end of the mixing cylinder guide rod are fastened together. The bottom of the fat emulsion mixing chamber is fastened to the second-layer plate. The upward movement of the mixing cylinder drives the mixing piston upward, and the fat emulsion is drawn from the fat emulsion chamber into the fat emulsion mixing chamber. When the fat emulsion flows, a negative pressure is generated at the opening of the third concentrate syringe. The concentrate in the third concentrate syringe is slowly mixed into the fat emulsion. Through this mixing method, the concentrate can be mixed into all parts of the fat emulsion without stirring. The mixed fat emulsion is then pressed into the three-stage mixing chamber by the mixing cylinder.

[0011] Furthermore, the three-stage mixing chamber includes a three-stage mixing chamber body, a discharge electric cylinder, a discharge piston, a spiral coil, an aqueous solution inlet, a grease solution inlet, and a nutrient solution outlet. The bottom of the three-stage mixing chamber body is fastened to the upper surface of a single-layer plate. The discharge electric cylinder is installed on the upper surface of the three-stage mixing chamber body, and the guide rod of the discharge electric cylinder extends into the interior of the three-stage mixing chamber body. The front end of the guide rod of the discharge electric cylinder body is fastened to the discharge piston. The spiral coil is wound around the outer wall of the three-stage mixing chamber body. The aqueous solution inlet and the grease solution inlet are installed on both sides of the bottom of the side wall of the three-stage mixing chamber body. The aqueous solution inlet and the grease solution inlet are equipped with check valves, allowing inflow but not outflow. The aqueous solution inlet is connected to the transfer chamber, and the grease solution inlet is connected to the third mixing component. The nutrient solution outlet is installed at the bottom of the three-stage mixing chamber body, and the nutrient solution outlet is equipped with a check valve, allowing outflow but not inflow. The upward movement of the discharge cylinder draws the mixed aqueous and lipid solutions into the three-stage mixing chamber. Because the lipid emulsion contains the emulsifier lecithin, lecithin molecules are tightly packed at the interface between the oil droplets and the aqueous phase, preventing direct contact between the oil droplets. Furthermore, due to the ionization and adsorption of lecithin molecules, the oil droplet interface carries a certain amount of negative charge. When the aqueous and lipid solutions are mixed, the lower density of the oil droplets easily leads to uneven mixing. Excessive force from stirring can cause collisions between different oil droplets, resulting in excessively large droplets that can clog blood vessels. This invention utilizes a spiral coil wound around the outer wall of a three-stage mixing chamber to create an upward electric field within the chamber. By adjusting the current, the force balance density of the negative charges at the oil droplet interface is affected by this electric field, ensuring that the downward force on the oil droplets is the same as that on the solution. Because the oil droplets are surrounded by negative charges, they repel each other, eventually causing them to disperse evenly throughout the solution space. This method prevents the formation of an oil layer on the surface of the nutrient solution even after prolonged standing. Furthermore, since the device operates at a temperature below room temperature, the nutrient solution is more stable at this temperature. However, the nutrient solution needs to be allowed to stand at room temperature before use after being delivered to the infusion bag. Therefore, this invention introduces a high-frequency alternating current through the spiral coil, causing the oil droplets to experience rapidly fluctuating forces, resulting in rapid vibration within a very small range. The rapidly vibrating oil droplets generate heat, quickly warming the nutrient solution to room temperature. This allows the nutrient solution delivered to the infusion bag to be used directly, significantly alleviating the problem of insufficient nutrient supply when there are many patients.

[0012] Furthermore, the three-stage mixing chamber also includes a reversing valve, a vacuum generator, and a sealing connector. One inlet of the reversing valve is connected to the nutrient solution outlet, and the other inlet is connected to the negative pressure end of the vacuum generator. The sealing connector is connected to the output port of the reversing valve. When the infusion bag and the sealing connector are sealed together, the reversing valve connects the negative pressure end of the vacuum generator to the sealing connector, extracting air from the infusion bag. The regulating valve core of the reversing valve connects the nutrient solution outlet to the sealing connector, allowing the nutrient solution to be poured into the infusion bag. The vacuum generator effectively prevents residual air in the infusion bag from entering the patient's blood vessels with the nutrient solution, thus protecting the patient's health.

[0013] Compared with existing technologies, the beneficial effects achieved by this invention are as follows: This invention, through a sealed device, ensures that the entire preparation process is free from external environmental contamination. Simultaneously, the extraction-type liquid inlet method synchronizes the proportioning accuracy with the servo motor accuracy. The proportioning adjustment method, controlled by a program, is far more accurate than manual proportioning. Furthermore, this invention uses a spiral coil to balance the buoyancy of oil droplets due to their low density, allowing the oil droplets to diffuse evenly in the solution. Attached Figure Description

[0014] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used in conjunction with embodiments of the invention to explain the invention and do not constitute a limitation thereof. In the drawings:

[0015] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0016] Figure 2 This is a cross-sectional view of the first hybrid component of the present invention;

[0017] Figure 3 This is a partially enlarged view A of the present invention;

[0018] Figure 4 This is a partially enlarged view B of the present invention;

[0019] Figure 5 This is a schematic diagram of the structure of the first hybrid component of the present invention;

[0020] Figure 6 This is a partial cross-sectional view of the transfer cavity of the present invention;

[0021] Figure 7 This is a partial cross-sectional view of the third hybrid component of the present invention;

[0022] Figure 8 This is a partial cross-sectional view of the three-stage mixing chamber of the present invention;

[0023] Figure 9 This is a partially enlarged view C of the present invention;

[0024] In the diagram: 1-First mixing assembly, 11-Amino acid solution chamber, 12-First primary mixing chamber, 121-Electric cylinder, 122-Primary mixing chamber body, 1221-Solution inlet, 1222-Injector inlet, 123-Blade, 124-Inner piston ring, 125-Outer piston ring, 126-Inner base plate ring, 127-Outer base plate ring, 1271-Solution outlet, 128-Lead screw nut mounting plate, 129-Lead screw, 1210-Lead screw nut, 13-First concentrated solution injector, 2-Second mixing assembly, 21-Glucose solution chamber, 22-Second primary mixing chamber, 23-Second concentrated solution injector, 3-Third mixing assembly, 31-Fat emulsion 32-Third-stage mixing chamber, 321-Fat emulsion mixing chamber, 322-Mixing cylinder, 323-Mixing piston, 324-Fat solution outlet, 325-Fat emulsion inlet, 33-Third concentrated solution syringe, 4-Second-stage mixing chamber, 5-Transfer chamber, 51-Transfer cylinder, 52-Transfer piston, 53-Transfer chamber, 54-Inlet, 55-Outlet, 6-Third-stage mixing chamber, 61-Third-stage mixing chamber, 62-Discharge cylinder, 63-Discharge piston, 64-Spiral coil, 65-Aqueous solution inlet, 66-Fat solution inlet, 67-Nutrient solution outlet, 68-Reversing valve, 69-Vacuum generator, 610-Sealing joint, 7-Frame. Detailed Implementation

[0025] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0026] Please see Figures 1-9 The present invention provides the following technical solution:

[0027] like Figure 1As shown, a parenteral nutrition solution mixing and delivery device includes a first mixing component 1, a second mixing component 2, a third mixing component 3, a secondary mixing chamber 4, a transfer chamber 5, a tertiary mixing chamber 6, and a frame 7. The frame 7 includes a first layer, a second layer, a third layer, a fourth layer, and a fifth layer, with the first layer at the bottom and the fifth layer at the top. The second, third, and fourth layers are arranged in a bottom-up order, and support columns are installed between each layer. The top sides of the first mixing component 1 and the second mixing component 2 are connected to the fifth layer, and the middle positions of the first mixing component 1 and the second mixing component 2 are fastened to the fourth layer. The first mixing assembly 1 and the second mixing assembly 2 are securely connected to the bottom of the three-layer plate. The first mixing assembly 1 and the second mixing assembly 2 are connected to the top of the secondary mixing chamber 4 via infusion pipes. The bottom of the secondary mixing chamber 4 and the transfer chamber 5 are securely connected to the second-layer plate. The bottom of the secondary mixing chamber 4 is connected to the transfer chamber 5 via infusion pipes. The transfer chamber 5 is connected to the tertiary mixing chamber 6 via infusion pipes. The third mixing assembly 3 is mounted on the top of the three-layer plate and on the bottom of the second-layer plate. The third mixing assembly 3 is connected to the tertiary mixing chamber 6 via pipes. The tertiary mixing chamber 6 is mounted on the first-layer plate. The first mixing assembly 1 mixes phosphate-free electrolytes, water-soluble vitamins, and trace elements into the compound amino acid solution. The second mixing assembly 2 mixes phosphates into the glucose solution. The third mixing assembly 3 mixes fat-soluble vitamins into the fat emulsion. The secondary mixing chamber 4 further mixes the already mixed amino acid solution and glucose solution. The intermediate transfer chamber agitates the mixture to ensure thorough mixing. The tertiary mixing chamber 6 adds a fat emulsion containing fat-soluble and water-soluble vitamins to the amino acid and glucose mixture. This device, through the coordinated operation of its components, enables the rapid and accurate preparation of large quantities of parenteral nutrition solution. Furthermore, the preparation process is conducted within a sealed container, preventing contamination of the nutrient solution by the external environment. The tertiary mixing chamber 6 of this invention also generates a reverse electric field through a spiral coil, increasing the downward force on the oil phase in the fat emulsion and preventing stratification that may occur during prolonged standing.

[0028] like Figures 1-5As shown, the first mixing assembly 1 comprises an amino acid solution chamber 11, a first primary mixing chamber 12, and a first concentrated solution syringe 13. The amino acid solution chamber 11 is fastened to a five-layer plate. An infusion tube at the bottom of the amino acid solution chamber 11 connects to the bottom of the side wall of the first primary mixing chamber 12. The middle of the first primary mixing chamber 12 is fastened to a four-layer plate, and the bottom of the first primary mixing chamber 12 is fastened to a three-layer plate. The first concentrated solution syringe 13 is connected to the bottom of the side wall of the first primary mixing chamber 12. Before preparing the primary mixing solution, the required phosphate-free electrolytes, water-soluble vitamins, trace elements, and a small amount of amino acid solution are mixed according to the prescribed dosage to form a concentrated solution. The concentrated solution is then drawn into the first concentrated solution syringe 13, which is then inserted into the syringe inlet. When the first primary mixing chamber 12 begins operation, the electric cylinder 121 drives the piston upward. Within the sealed space, the upward movement of the piston generates suction, drawing both the liquid in the amino acid solution chamber 11 and the liquid in the first concentrated solution syringe 13 into the primary mixing chamber 122. Since the amount of concentrated solution is much less than that of amino acid solution, the concentrated solution will be completely drawn in and diluted by the amino acid solution. The total amount of mixed solution is controlled by the shrinkage size of electric cylinder 121, which can accurately reach the standard configuration amount. The configuration process isolates the outside air and effectively prevents external pollutants and gases from affecting the mixed solution.

[0029] like Figures 1-5As shown, the first-stage mixing chamber 12 includes an electric cylinder 121, a first-stage mixing chamber 122, a blade 123, an inner piston ring 124, an outer piston ring 125, an inner bottom plate ring 126, an outer bottom plate ring 127, a lead screw and nut mounting plate 128, a lead screw 129, and a lead screw and nut 1210. The bottom side of the inner wall of the first-stage mixing chamber 122 is fastened to the outer side of the outer bottom plate ring 127. The bottom of the outer bottom plate ring 127 is fastened to the four-layer plate. The electric cylinder 121 is installed on the top of the first-stage mixing chamber 122. The guide rod of the electric cylinder 121 extends into the interior of the first-stage mixing chamber 122. The guide rod of the electric cylinder 121 is fastened to the inner piston ring 124 through a mounting seat. The inner piston ring 124 and the outer piston ring 125 are rotatably sealed. Next, the piston outer ring 125 can slide axially and sealably on the inner wall of the primary mixing chamber 122. The bottom plate inner ring 126 and the bottom plate outer ring 127 are rotatably and sealably connected. The top of the blade 123 is fastened to the bottom of the piston outer ring 125. The bottom of the blade 123 is fastened to the top of the screw nut mounting plate 128. The middle part of the blade 123 passes through the bottom plate inner ring 126. The part of the blade 123 that passes through the bottom plate inner ring 126 is sealed to the bottom plate inner ring 126. The screw nut 1210 is fastened to the screw nut mounting plate 128. The bottom of the screw 129 is fastened to the three-layer plate. The top of the screw 129 is rotatably connected to the bottom plate inner ring 126 through a bearing. The screw 129 passes through the screw nut 1210. The electric cylinder 121 moves the inner piston ring 124 upward, which in turn moves the outer piston ring 125 upward. When the inner and outer piston rings 124 and 125 move upward together, a suction force is generated within the sealed cavity, drawing the solution into the primary mixing chamber 122. As the outer piston ring 125 moves upward, the blades 123 connected to it move the lead screw nut mounting plate 128 upward. This upward movement of the mounting plate causes relative displacement between the lead screw nut 1210 and the lead screw 129. Since the lead screw 129 is stationary, the lead screw nut 1210 rotates, causing the mounting plate 128 to rotate. The mounting plate 128 then rotates the blades 123, which in turn mixes the concentrated solution and the amino acid solution evenly. This device utilizes the lifting and lowering of the electric cylinder 121 to rotate the blades 123, reducing the need for a separate motor and lowering the overall cost.

[0030] like Figures 1-5As shown, the bottom side wall of the primary mixing chamber 122 has a solution inlet 1221 and a syringe inlet 1222. Both the solution inlet 1221 and the syringe inlet 1222 are equipped with check valves, which allow inflow but not outflow. The solution inlet 1221 is connected to the amino acid solution chamber 11 via a solution pipe, and the syringe inlet 1222 is connected to the first concentrated solution syringe 13. The outer ring 127 of the base plate has a solution outlet 1271, which is also equipped with a check valve, allowing outflow but not inflow. The solution outlet 1271 is connected to the top of the secondary mixing chamber 4 via an infusion pipe. The check valve at the solution outlet 1271 ensures that the solution outlet 1271 remains closed when liquid is drawn in. The check valves at the solution inlet 1221 and the syringe inlet 1222 ensure that when the solution is discharged from the primary mixing chamber 122, it flows out only from the solution outlet and does not flow back into the solution inlet 1221 and the syringe inlet 1222.

[0031] like Figures 1-5 As shown, the second mixing assembly 2 comprises a glucose solution chamber 21, a second primary mixing chamber 22, and a second concentrated solution syringe 23. The glucose solution chamber 21 is securely connected to a five-layer plate. An infusion tube is located at the bottom of the glucose solution chamber 21, connecting it to the bottom of the side wall of the second primary mixing chamber 22. The second primary mixing chamber 22 is securely connected to a four-layer plate at its middle position and to a three-layer plate at its bottom. The second concentrated solution syringe 23 is connected to the bottom of the side wall of the second primary mixing chamber 22. The second primary mixing chamber 22 is identical to the first primary mixing chamber 12 in structure, except for the mixing solution. The substance mixed in the second concentrated solution syringe 23 is phosphate. Phosphate is mixed separately into the glucose solution because phosphate reacts with calcium in the added amino acid solution to form calcium phosphate precipitation, which can clog the microvessels in the lungs. Dissolving the phosphate in the glucose solution first, and then mixing the glucose solution with the amino acid solution, avoids this problem.

[0032] like Figure 1 , 6As shown, the transfer chamber 5 includes a transfer electric cylinder 51, a transfer piston 52, a transfer chamber body 53, an inlet 54, and an outlet 55. The bottom of the transfer chamber body 53 is fastened to the second-layer plate. The transfer electric cylinder 51 is installed on the top of the transfer chamber body 53. The guide rod of the transfer electric cylinder 51 extends out of the transfer chamber body 53, and the front end of the guide rod is fastened to the transfer piston 52. The transfer piston 52 can slide axially and sealed within the inner wall of the transfer chamber body 53. The inlet 54 and the outlet 55 are installed on both sides of the bottom of the side wall of the transfer chamber body 53. Both the inlet 54 and the outlet 55 are equipped with check valves. The check valve of the inlet 54 allows inflow but not outflow, while the check valve of the outlet 55 allows outflow but not inflow. The inlet 54 is connected to the bottom of the secondary mixing chamber 4 through a delivery pipe, and the outlet 55 is connected to the tertiary mixing chamber 6 through a delivery pipe. The mixed solution is drawn into the transfer chamber 53 from the inlet 54 at the bottom side of the transfer chamber 53. The solution that was originally at the bottom is now at the top, which is equivalent to inverting the solution. The two different solutions are mixed more evenly after being inverted. After the solutions are mixed, the transfer cylinder 51 presses down, which drives the transfer piston 52 to press down. The mixed solution is then pressed from the outlet 55 into the third-stage mixing chamber 61.

[0033] like Figure 1 , 7 As shown, the third mixing component 3 includes a fat emulsion chamber 31, a third primary mixing chamber 32, and a third concentrated solution injector 33. The third primary mixing chamber 32 includes a fat emulsion mixing chamber 321, a mixing cylinder 322, a mixing piston 323, a fat solution outlet 324, and a fat emulsion inlet 325. The fat emulsion chamber 31 is mounted on a three-layer plate. The bottom of the fat emulsion chamber 31 is connected to the fat emulsion inlet 325 via an infusion pipe. The fat emulsion inlet 325 has a one-way valve inside, which allows inflow but not outflow. An injection port is opened on the side of the fat emulsion inlet 325. The third concentrated solution injector 33... The injector 33 is inserted into the injection port. The lipid solution outlet 324 is installed at the bottom of the lipid emulsion mixing chamber 321. The lipid solution outlet 324 is equipped with a one-way valve that allows outflow but not inflow. The lipid solution outlet 324 is connected to the three-stage mixing chamber 6 through an infusion tubing. The mixing cylinder 322 is installed at the top of the lipid emulsion mixing chamber 321. The guide rod of the mixing cylinder 322 extends into the interior of the lipid emulsion mixing chamber 321. The mixing piston 323 is fastened to the front end of the guide rod of the mixing cylinder 322. The bottom of the lipid emulsion mixing chamber 321 is fastened to the second-layer plate. The upward movement of the mixing cylinder 322 causes the mixing piston 323 to move upward, and the fat emulsion is drawn from the fat emulsion cavity 31 into the fat emulsion mixing cavity 321. When the fat emulsion flows, a negative pressure is generated at the opening of the third concentrated solution injector 33, and the concentrated solution in the third concentrated solution injector 33 is slowly mixed into the fat emulsion. Through this mixing method, the concentrated solution can be mixed to all parts of the fat emulsion without stirring. The mixed fat emulsion is then pressed into the three-stage mixing cavity 6 by the mixing cylinder 322.

[0034] like Figure 1 , 8 As shown, the three-stage mixing chamber 6 includes a three-stage mixing chamber body 61, a discharge electric cylinder 62, a discharge piston 63, a spiral coil 64, an aqueous solution inlet 65, a lipid solution inlet 66, and a nutrient solution outlet 67. The bottom of the three-stage mixing chamber body 61 is fastened to the upper surface of a single-layer plate. The discharge electric cylinder 62 is installed on the upper surface of the three-stage mixing chamber body 61, and the guide rod of the discharge electric cylinder 62 extends into the interior of the three-stage mixing chamber body 61. The front end of the guide rod of the discharge electric cylinder 62 is fastened to the discharge piston 63. The spiral coil 64 is wound around the outer wall of the three-stage mixing chamber body 61. The aqueous solution inlet 65 and the lipid solution inlet 66 are installed on both sides of the bottom of the side wall of the three-stage mixing chamber body 61. The aqueous solution inlet 65 and the lipid solution inlet 66 are equipped with check valves, allowing inflow but not outflow. The aqueous solution inlet 65 is connected to the transfer chamber 5, and the lipid solution inlet 66 is connected to the third mixing component 3. The nutrient solution outlet 67 is installed at the bottom of the three-stage mixing chamber body 61, and the nutrient solution outlet 67 is equipped with a check valve, allowing outflow but not inflow. The upward movement of the discharge cylinder 62 draws the mixed aqueous and lipid solutions into the three-stage mixing chamber 61. Because the lipid emulsion contains the emulsifier lecithin, lecithin molecules are tightly packed at the interface between the oil droplets and the aqueous phase, preventing direct contact between the oil droplets. Furthermore, due to the ionization and adsorption of lecithin molecules, the oil droplet interface carries a certain amount of negative charge. When the aqueous and lipid solutions are mixed, the lower density of the oil droplets easily leads to uneven mixing. Excessive stirring force can cause collisions between different oil droplets, resulting in excessively large droplets that can clog blood vessels. This invention utilizes a spiral coil 64 wound around the outer wall of a three-stage mixing chamber 61 to create an upward electric field within the chamber. By adjusting the current magnitude, the force balance density of the negative charges on the oil droplet interface is affected by this electric field, ensuring that the downward force on the oil droplets is the same as that on the solution. Because the oil droplets are surrounded by negative charges, they repel each other, eventually causing them to disperse evenly throughout the solution space. This method prevents the formation of an oil layer on the surface of the nutrient solution even after prolonged standing. Furthermore, since the operating environment of this device is below room temperature, the properties of the nutrient solution are more stable at this temperature. However, the nutrient solution needs to be allowed to stand at room temperature before use after being delivered to the infusion bag. Therefore, this invention introduces a high-frequency alternating current through the spiral coil 64, causing the oil droplets to experience rapidly fluctuating forces, resulting in rapid vibration within a very small range. The rapidly vibrating oil droplets generate heat, quickly warming the nutrient solution to room temperature. This allows the nutrient solution delivered to the infusion bag to be used directly, significantly alleviating the problem of insufficient nutrient solution supply when there are many patients.

[0035] like Figure 1 , 9As shown, the three-stage mixing chamber 6 also includes a reversing valve 68, a vacuum generator 69, and a sealing connector 610. One input port of the reversing valve 68 is connected to the nutrient solution outlet 67, and the other input port of the reversing valve 68 is connected to the negative pressure end of the vacuum generator 69. The sealing connector 610 is connected to the output port of the reversing valve 68. When the infusion bag and the sealing connector 610 are sealed together, the reversing valve connects the negative pressure end of the vacuum generator 69 and the sealing connector 610, and the air in the infusion bag is extracted. The regulating valve core of the reversing valve 68 connects the nutrient solution outlet 67 and the sealing connector, and the nutrient solution is poured into the infusion bag. By creating a vacuum through the vacuum generator 69, residual air in the infusion bag can be effectively prevented from entering the patient's blood vessels with the nutrient solution, thus protecting the patient's health.

[0036] The working principle of this invention is as follows: The electric cylinder 121 drives the piston to move, mixing phosphate-free electrolytes, water-soluble vitamins, and trace elements into the compound amino acid solution. As the lead screw nut moves along the lead screw, it drives the blades to rotate, stirring the amino acid solution to ensure complete solute dissolution. The second mixing component 2, following the same working principle as the first mixing component 1, mixes phosphates into the glucose solution. The third mixing component 3 mixes fat-soluble vitamins into the fat emulsion. The secondary mixing chamber 4 mixes the mixed amino acid solution and the mixed glucose solution a second time, while the transfer chamber tumbles the mixed solution to ensure thorough mixing. The tertiary mixing chamber 6 adds the fat emulsion containing the mixed fat-soluble and water-soluble vitamins to the amino acid and glucose mixture. The spiral coil 64 balances the buoyancy of the oil droplets due to their lower density, allowing the droplets to diffuse evenly in the solution. The infusion bag and sealing connector 610 are sealed together. The vacuum generator 69 extracts all air from the infusion bag, and the nutrient solution is then introduced into the infusion bag.

[0037] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A parenteral nutrition solution preparation and delivery device, characterized in that: The mixing and conveying device includes a first mixing component (1), a second mixing component (2), a third mixing component (3), a secondary mixing chamber (4), a transfer chamber (5), a tertiary mixing chamber (6), and a frame (7). The frame (7) includes a first layer, a second layer, a third layer, a fourth layer, and a fifth layer. The first layer is at the bottom, and the fifth layer is at the top. The second, third, and fourth layers are arranged in order from bottom to top. Support columns are installed between each layer. The top sides of the first mixing component (1) and the second mixing component (2) are connected to the fifth layer. The middle positions of the first mixing component (1) and the second mixing component (2) are fastened to the fourth layer. The bottom side of the second mixing component (2) is fastened to the three-layer plate. The first mixing component (1) and the second mixing component (2) are connected to the top of the secondary mixing chamber (4) through the infusion pipe. The bottom of the secondary mixing chamber (4) and the transfer chamber (5) are fastened to the two-layer plate. The bottom of the secondary mixing chamber (4) is connected to the transfer chamber (5) through the infusion pipe. The transfer chamber (5) is connected to the tertiary mixing chamber (6) through the infusion pipe. The top of the third mixing component (3) is installed on the three-layer plate. The bottom of the third mixing component (3) is installed on the two-layer plate. The third mixing component (3) is connected to the tertiary mixing chamber (6) through the pipe. The tertiary mixing chamber (6) is installed on the first layer plate. The first mixing assembly (1) comprises an amino acid solution chamber (11), a first primary mixing chamber (12), and a first concentrated solution syringe (13). The amino acid solution chamber (11) is fastened to a five-layer plate. The bottom of the amino acid solution chamber (11) has an infusion pipe connected to the bottom of the side wall of the first primary mixing chamber (12). The middle position of the first primary mixing chamber (12) is fastened to a four-layer plate. The bottom of the first primary mixing chamber (12) is fastened to a three-layer plate. The first concentrated solution syringe (13) is connected to the bottom of the side wall of the first primary mixing chamber (12). The first-stage mixing chamber (12) includes an electric cylinder (121), a first-stage mixing chamber body (122), a blade (123), an inner piston ring (124), an outer piston ring (125), an inner bottom plate ring (126), an outer bottom plate ring (127), a lead screw nut mounting plate (128), a lead screw (129), and a lead screw nut (1210). The bottom side of the inner wall of the first-stage mixing chamber (122) is fastened to the outer side of the outer bottom plate ring (127). The bottom of the outer bottom plate ring (127) is fastened to the four-layer plate. The electric cylinder (121) is installed on the top of the first-stage mixing chamber (122). The guide rod of the electric cylinder (121) extends into the interior of the first-stage mixing chamber (122). The guide rod of the electric cylinder (121) is fastened to the inner piston ring (124) through a mounting seat. The inner piston ring (124) and the outer piston ring (125) are rotatably connected. The piston outer ring (125) can slide axially and sealed within the inner wall of the primary mixing chamber (122). The inner ring (126) and outer ring (127) of the base plate are rotatably and sealed. The top of the blade (123) is fastened to the bottom of the piston outer ring (125). The bottom of the blade (123) is fastened to the top of the screw nut mounting plate (128). The middle part of the blade (123) passes through the inner ring (126) of the base plate. The part of the blade (123) that passes through the inner ring (126) of the base plate is sealed to the inner ring (126). The screw nut (1210) and screw nut mounting plate (128) are fastened to each other. The bottom of the screw (129) is fastened to the three-layer plate. The top of the screw (129) and inner ring (126) of the base plate are rotatably connected by a bearing. The screw (129) passes through the screw nut (1210).

2. The parenteral nutrition solution mixing and delivery device according to claim 1, characterized in that: The bottom of the side wall of the primary mixing chamber (122) has a solution inlet (1221) and a syringe inlet (1222). Both the solution inlet (1221) and the syringe inlet (1222) are equipped with check valves. The check valves allow inflow but not outflow. The solution inlet (1221) is connected to the amino acid solution chamber (11) through a solution pipe. The syringe inlet (1222) is connected to the first concentrated solution syringe (13). The outer ring (127) of the bottom plate has a solution outlet (1271). The solution outlet (1271) is also equipped with a check valve. The check valves allow outflow but not inflow. The solution outlet (1271) is connected to the top of the secondary mixing chamber (4) through an infusion pipe.

3. The parenteral nutrition solution mixing and delivery device according to claim 2, characterized in that: The second mixing assembly (2) comprises a glucose solution chamber (21), a second primary mixing chamber (22), and a second concentrated solution syringe (23). The glucose solution chamber (21) is fastened to a five-layer plate. The bottom of the glucose solution chamber (21) is connected to the bottom of the side wall of the second primary mixing chamber (22) via an infusion pipe. The middle position of the second primary mixing chamber (22) is fastened to a four-layer plate. The bottom of the second primary mixing chamber (22) is fastened to a three-layer plate. The second concentrated solution syringe (23) is connected to the bottom of the side wall of the second primary mixing chamber (22). The second primary mixing chamber (22) is the same as the first primary mixing chamber (12) except that the mixed solution is different from that of the first primary mixing chamber (12).

4. The parenteral nutrition solution mixing and delivery device according to claim 3, characterized in that: The transfer chamber (5) includes a transfer electric cylinder (51), a transfer piston (52), a transfer chamber body (53), an inlet (54), and an outlet (55). The bottom of the transfer chamber body (53) is fastened to the second-layer plate. The transfer electric cylinder (51) is installed on the top of the transfer chamber body (53). The guide rod of the transfer electric cylinder (51) extends out of the transfer chamber body (53), and the front end of the guide rod is fastened to the transfer piston (52). The transfer piston (52) can move within the transfer chamber body (53). 53) The inner wall is axially sealed and sliding. The inlet (54) and outlet (55) are installed on both sides of the bottom of the side wall of the transfer chamber (53). Both the inlet (54) and outlet (55) are equipped with check valves. The check valve of the inlet (54) can only be used for inlet but not for outlet. The check valve of the outlet (55) can only be used for outlet but not for inlet. The inlet (54) is connected to the bottom of the secondary mixing chamber (4) through the infusion pipeline. The outlet (55) is connected to the tertiary mixing chamber (6) through the infusion pipeline.

5. The parenteral nutrition solution mixing and delivery device according to claim 4, characterized in that: The third mixing component (3) includes a fat emulsion chamber (31), a third primary mixing chamber (32), and a third concentrated solution injector (33). The third primary mixing chamber (32) includes a fat emulsion mixing chamber body (321), a mixing cylinder (322), a mixing piston (323), a fat solution outlet (324), and a fat emulsion inlet (325). The fat emulsion chamber (31) is mounted on a three-layer plate. The bottom of the fat emulsion chamber (31) is connected to the fat emulsion inlet (325) through an infusion pipe. The fat emulsion inlet (325) has a one-way valve inside, which allows inflow but not outflow. An injection port is opened on the side of the fat emulsion inlet (325). The three-concentrate syringe (33) is inserted into the injection port. The lipid solution outlet (324) is installed at the bottom of the fat emulsion mixing chamber (321). The lipid solution outlet (324) is equipped with a one-way valve that allows outflow but not inflow. The lipid solution outlet (324) is connected to the three-stage mixing chamber (6) through an infusion tubing. The mixing electric cylinder (322) is installed at the top of the fat emulsion mixing chamber (321). The guide rod of the mixing electric cylinder (322) extends into the fat emulsion mixing chamber (321). The mixing piston (323) is fastened to the front end of the guide rod of the mixing electric cylinder (322). The bottom of the fat emulsion mixing chamber (321) is fastened to the second-layer plate.

6. The parenteral nutrition solution mixing and delivery device according to claim 5, characterized in that: The three-stage mixing chamber (6) includes a three-stage mixing chamber body (61), a discharge electric cylinder (62), a discharge piston (63), a spiral coil (64), an aqueous solution inlet (65), a lipid solution inlet (66), and a nutrient solution outlet (67). The bottom of the three-stage mixing chamber body (61) is fastened to the upper surface of a single-layer plate. The discharge electric cylinder (62) is installed on the upper surface of the three-stage mixing chamber body (61). The guide rod of the discharge electric cylinder (62) extends into the interior of the three-stage mixing chamber body (61). The front end of the guide rod of the discharge electric cylinder (62) is fastened to the discharge piston (63). The spiral coil ( 64) The aqueous solution inlet (65) and the lipid solution inlet (66) are wound around the outer wall of the three-stage mixing chamber (61). The aqueous solution inlet (65) and the lipid solution inlet (66) are installed on both sides of the bottom of the side wall of the three-stage mixing chamber (61). The aqueous solution inlet (65) and the lipid solution inlet (66) are equipped with check valves, which allow in but not out. The aqueous solution inlet (65) is connected to the transfer chamber (5), and the lipid solution inlet (66) is connected to the third mixing component (3). The nutrient solution outlet (67) is installed at the bottom of the three-stage mixing chamber (61). The nutrient solution outlet (67) is equipped with a check valve, which allows out but not in.

7. The parenteral nutrition solution mixing and delivery device according to claim 6, characterized in that: The three-stage mixing chamber (6) also includes a reversing valve (68), a vacuum generator (69), and a sealing joint (610). One input port of the reversing valve (68) is connected to the nutrient solution outlet (67), and the other input port of the reversing valve (68) is connected to the negative pressure end of the vacuum generator (69). The sealing joint (610) is connected to the output port of the reversing valve (68).

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