A drug film for relieving knee arthritis symptoms that can be used at home and a preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, and provides a medicine film for relieving the symptoms of knee arthritis that can be used at home and a preparation method thereof, comprising main ingredients and auxiliary ingredients, wherein the main ingredients include the following raw materials by weight: 10-50g of gynostemma pentaphyllum, 20-50g of sappan wood, 10-35g of mountain conch, 10-30g of processed rhubarb, 10-50g of clematis, 10-30g of radix scutellariae, 20-50g of corydalis, 10-30g of liquorice, 9-20g of asarum, 10-50g of millettia reticulata, and 15-60g of honeysuckle vine; and the auxiliary ingredients include vaseline and beeswax. The medicine film can effectively disperse the stasis in the human body through the coordinated use of the main ingredients, disperse the stasis and reduce swelling, activate blood circulation and remove stasis, relieve pain, promote blood circulation, improve the stasis state of local tissues, and dredge meridians. Through the use of auxiliary ingredients, Chinese medicine can be directly applied to the lesion site, with rapid onset of effect, quick results, no sensitization, and no allergic reactions; it can be used continuously, is easy to use, has no odor, no foreign body sensation, and does not stain the skin or clothing.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a medicine film for relieving knee arthritis symptoms that can be used at home and a preparation method thereof. Background Art

[0002] Knee osteoarthritis (KOA) is a chronic degenerative bone and joint disease, which refers to an inflammatory disease in the human joints and surrounding tissues. The lesions are chronic and often occur in people after middle age. Clinical manifestations include redness, swelling, heat, pain, dysfunction and joint deformity of the joints. Pathological changes initially occur in the articular cartilage, and then invade the subchondral bone plate and synovium and other surrounding joint tissues. The main characteristics are cartilage degeneration and new bone formation on the articular surface and its edges. The pathogenesis is relatively complex and is generally believed to be related to factors such as aging, trauma, inflammation, obesity, autoimmune response, metabolism and genetics, and degenerative lesions. Severe cases can lead to joint disability and affect the quality of life of patients.

[0003] The prevalence of symptomatic KOA in the middle-aged and elderly population in my country is 8.1%, and there is a certain upward trend. The disease seriously affects the quality of life of patients and has a certain disability rate, which places a huge burden on society and families. The clinical manifestations are knee pain, swelling, and stiffness. There are many ways to treat this disease in traditional Chinese medicine, and the effect is definite. Traditional Chinese medicine treatment mainly uses acupuncture, which is one of the traditional Chinese therapies. It is safe, economical, and effective, and has a high application value in the treatment of knee arthritis.

[0004] In actual clinical practice, many patients with knee osteoarthritis often have joint dysfunction, which makes it inconvenient for them to go out, delaying treatment. In addition, the treatment process requires family members to accompany them, which increases the time cost. KOA has a high incidence and recurrence rate, so a simple and effective home-use drug film has become a demand. Summary of the invention

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] The invention provides a medicine film for relieving knee arthritis symptoms that can be used at home. The medicine film comprises a main ingredient and an auxiliary ingredient. The main ingredient comprises the following raw materials in parts by weight: 10-50g of gynostemma pentaphyllum, 20-50g of sappan wood, 10-35g of mountain conch, 10-30g of processed rhubarb, 10-50g of clematis root, 10-30g of radix scutellariae, 20-50g of corydalis, 10-30g of liquorice, 9-20g of asarum, 10-50g of millettia reticulata, 15-60g of honeysuckle vine and 15-50g of lapsang souchong black tea; and the auxiliary ingredient comprises vaseline, paraffin and beeswax.

[0007] Gynostemma pentaphyllum: enters the lung, spleen and kidney meridians, has the effects of clearing away heat and inflammation, and replenishing qi deficiency.

[0008] Su Mu: Su Mu is neutral in nature and belongs to the Liver Meridian. Its main functions and effects are promoting qi, activating blood circulation and removing blood stasis, reducing swelling and relieving pain.

[0009] Mountain conch: It enters the lung, liver, spleen, and large intestine meridians, and has the effects of clearing heat, reducing swelling, detoxifying, and discharging pus.

[0010] Prepared rhubarb: has the effects of clearing away heat and detoxifying, stopping bleeding, and promoting blood circulation and removing blood stasis.

[0011] Clematis: It belongs to the bladder meridian and is an anti-rheumatic drug that has the effects of removing rheumatism and unblocking meridians.

[0012] Radix Polygoni Multiflori: It enters the liver and spleen meridians, relaxes muscles and promotes blood circulation, disperses blood stasis and reduces swelling, and has the effects of detoxifying and relieving pain.

[0013] Yuanhusuo: It has the effects of promoting blood circulation, removing blood stasis, promoting qi and relieving pain.

[0014] Millettia reticulata: warm in nature, enters the liver and kidney meridians, has the effects of relaxing muscles and tendons, activating blood circulation, replenishing blood and relieving pain.

[0015] Honeysuckle vine: It enters the lung meridian and stomach meridian, and has the effects of clearing away heat, detoxifying, dispersing wind and relieving pain.

[0016] Asarum: It enters the lung, heart, and kidney meridians, and has the effects of dispelling cold, removing wind and relieving pain.

[0017] Licorice: replenishes Qi, relieves pain, and harmonizes various medicines.

[0018] Zhengshan Xiaozhong black tea: anti-inflammatory, diuretic and detumescent effects

[0019] Vaseline, a mineral wax, is not absorbed by the skin and can form a protective film on the skin surface

[0020] Furthermore, the main ingredients include the following raw materials in parts by weight: 25-35g of Gynostemma pentaphyllum, 30-35g of Sappan wood, 15-20g of Conch shell, 10-20g of processed rhubarb, 20-30g of Clematis chinensis, 15-30g of Herba Polygoni Multiflori, 35-45g of Corydalis yanhusuo, 15-20g of Licorice, 10-15g of Asarum, 25-40g of Millettia reticulata, 25-50g of Honeysuckle vine and 20-35g of Lapsang souchong black tea.

[0021] Furthermore, the main ingredients include the following raw materials in parts by weight: 30-60 g of paraffin, 50-100 g of beeswax, 300-500 g of vaseline and 10-50 g of shea butter.

[0022] The present invention also provides a method for preparing a drug film for relieving knee arthritis symptoms that can be used at home, and the specific preparation steps are as follows:

[0023] Step 1: Weigh the main ingredients by weight: 10-50g of Gynostemma pentaphyllum, 20-50g of Sappan wood, 10-35g of Conch shell, 10-30g of processed rhubarb, 10-50g of Clematis chinensis, 10-30g of Herba Scutellariae radix, 20-50g of Corydalis yanhusuo, 10-30g of Licorice root, 9-20g of Asarum, 10-50g of Millettia reticulata, 15-60g of Honeysuckle vine, and 15-50g of Lapsang souchong black tea, and mix them together to remove impurities, wash, dry and sterilize;

[0024] Step 2: Mix the main ingredients and grind them into fine powder for later use;

[0025] Step 3: Preparation of auxiliary material components, take a clean 1000ml measuring cup, weigh 30-60g of paraffin and 50-100g of beeswax, first pour the paraffin and beeswax into the measuring cup, place the measuring cup on a closed electric stove and heat, after the paraffin and beeswax are dissolved, add 300-500g of vaseline, after the vaseline is completely dissolved, finally add 10-50g of shea butter, until it is completely dissolved, and turn off the electric stove;

[0026] Step 4: Preparation of the main ingredients: weigh 150-500g of the reserved Chinese medicine powder in step 1, pour it into a clean glass container, pour the liquid dissolved in step 3 into the Chinese medicine powder in batches, and stir with a stirrer until the Chinese medicine powder is completely dissolved in the liquid and becomes a paste;

[0027] Step 5: Prepare a clean, microwaveable food-grade fresh-keeping box, pour the paste from step 4 into the box, put it in a constant temperature box, and let it cool naturally. After at least 12 hours, take out the box and cover it with a sealed lid.

[0028] Furthermore, in step 1, the drying temperature is 50-60° C., and the temperature is repeatedly raised and lowered for 3 hours.

[0029] Furthermore, in step 2, the standard of the fine powder refers to that the fine powder can all pass through a 100-mesh sieve, and contains no less than 95% of the powder that can pass through a 120-mesh sieve.

[0030] Furthermore, in step three, the temperature of the electric furnace is 100° C. when the paraffin, beeswax and vaseline are dissolved.

[0031] Furthermore, in step 3, the temperature of the electric furnace is 70° C. when the shea butter is dissolved.

[0032] Furthermore, in step 4, 100 ml of the liquid in which the auxiliary materials are dissolved is poured in each time.

[0033] Furthermore, in step five, the temperature of the thermostat is 25°C.

[0034] Directions:

[0035] Take out the prepared medicine film box, open the sealed lid, put it in the microwave, heat it for 4 minutes, take it out of the fresh-keeping box and place it. Choose a wooden high-temperature resistant rice spoon as a tool for applying. Before applying, use a thermometer to measure the temperature of the medicine film to be below 45 degrees. Before starting to apply, first put a thickened plastic wrap under the affected knee, apply some medicine film in the center of the plastic wrap, place the popliteal fossa of the affected knee on the medicine film, and then start to apply the front side, take out the paste-like medicine film and apply it to the entire knee on the affected side. The upper half includes Liangqiu acupoint and Xuehai acupoint; the lower half includes Yinlingquan acupoint and Zusanli acupoint. During the application process, the medicine film will flow and flow on both sides of the knee. There is no need to scrape it off. Continue to apply it evenly. The thickness of the entire medicine film reaches 2-3 cm. One box of medicine film is used to apply one knee. After all the medicine films are used up, wrap the entire knee joint tightly with plastic wrap placed under the knee, and cover it with a warm blanket. After 30 minutes, the medicine film will cool and solidify, and you can peel it off as a whole and put it in a box for next use. No medicine film will remain on the skin. Each box of medicine films can be used continuously for 6 times, and can be discarded after use and a new one can be used.

[0036] The present invention has the following beneficial effects:

[0037] (1) The drug film for relieving the symptoms of knee arthritis prepared by the raw material formula of the present invention comprises the following main ingredients: gynostemma pentaphyllum, sappan wood, conch shell, processed rhubarb, clematis root, radix polygoni lobata, corydalis yanhusuo, liquorice, lapsang souchong black tea, asarum, millettia spatholobi and honeysuckle vine. Sappan wood has the effects of promoting qi, promoting blood circulation, removing blood stasis, reducing swelling and relieving pain; conch shell has the effects of clearing away heat, reducing swelling, detoxifying and discharging pus; clematis root has the effects of removing rheumatism and unblocking meridians; radix polygoni lobata has the effects of relaxing muscles and promoting blood circulation, dispersing blood stasis and reducing swelling, detoxifying and relieving pain The effects of the herb are as follows: Yuanhusuo has the effects of promoting blood circulation, removing blood stasis, promoting qi and relieving pain; Millettia reticulata has the effects of relaxing muscles and tendons, promoting blood circulation, replenishing blood and relieving pain; Honeysuckle has the effects of clearing away heat and detoxifying, dispersing wind and relieving pain; Zhengshan Xiaozhong black tea has the effects of anti-inflammatory, diuretic and swelling reduction; Asarum has the effects of dispersing cold, dispelling wind and relieving pain. The combined use of the main ingredients can effectively disperse the blood stasis in the human body; disperse the stagnation and reduce swelling, promote blood circulation and remove blood stasis, relieve pain, promote blood circulation, improve the stasis state of local tissues, and dredge the meridians.

[0038] (2) The auxiliary ingredients of the present invention are vaseline and beeswax, which will not be absorbed by the skin and can form a protective film on the skin surface. They act as a moisturizer and a lubricant at the same time and can directly contact with human skin. Through the use of auxiliary ingredients, the Chinese medicine can be directly applied to the lesion site, and the effect is rapid, quick, non-sensitizing, and no allergic phenomenon. It can be used continuously, is easy to use, has no odor, no foreign body sensation, and does not stain the skin and clothes. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 This is a comparison chart of VAS values ​​between the drug film group and the warm needle group before and after treatment. DETAILED DESCRIPTION

[0040] The following is a detailed description in conjunction with the accompanying drawings and specific implementation methods. It should be pointed out that the embodiments are only specific explanations of the invention and should not be regarded as limitations of the invention. The purpose of the embodiments is to enable those skilled in the art to better understand and reproduce the technical solutions of the present invention. The scope of protection of the present invention shall still be based on the scope defined by the claims.

[0041] Example 1

[0042] The present embodiment provides a medicine film for relieving the symptoms of knee arthritis that can be used at home, comprising a main ingredient and an auxiliary ingredient. The main ingredient comprises the following raw materials in parts by weight: 35 g of Gynostemma pentaphyllum, 20 g of Sappan wood, 25 g of Conch shell, 20 g of processed rhubarb, 25 g of Clematidis, 25 g of Herba Polygoni Multiflori, 20 g of Corydalis yanhusuo, 15 g of Licorice, 15 g of Asarum, 30 g of Millettia reticulata, 30 g of Honeysuckle vine and 20 g of Lapsang souchong black tea; the auxiliary ingredient comprises 80 g of paraffin, 40 g of beeswax, 300 g of vaseline and 30 g of shea butter.

[0043] The specific preparation steps are as follows:

[0044] Step 1: Weigh the main ingredients by weight: 35g of Gynostemma pentaphyllum, 20g of Sappan wood, 25g of Conch shell, 20g of processed rhubarb, 25g of Clematis chinensis, 25g of Herba Polygoni Multiflori, 20g of Corydalis yanhusuo, 15g of Licorice, 15g of Asarum, 30g of Millettia reticulata, 30g of Honeysuckle vine and 20g of Lapsang Souchong black tea; mix them together to remove impurities, wash, dry and sterilize; the drying temperature is 50-60°C, and the temperature is repeatedly raised and lowered for 3 hours.

[0045] Step 2: Mix the main ingredients and raw materials into fine powder for later use; the standard of the fine powder is that all powder can pass through a 100-mesh sieve and contain no less than 95% of powder that can pass through a 120-mesh sieve.

[0046] Step 3: Preparation of auxiliary material components, take a clean 1000ml measuring cup, weigh 80g of paraffin and 40g of beeswax, first pour the paraffin and beeswax into the measuring cup, place the measuring cup on a closed electric furnace and heat it at 100°C, wait for the paraffin and beeswax to dissolve, then add 300g of vaseline, wait for the vaseline to dissolve completely, lower the heating temperature of the electric furnace to 70°C, finally add 30g of shea butter, until it is completely dissolved, turn off the electric furnace;

[0047] Step 4: Preparation of the main ingredients: weigh 200g of the Chinese medicine powder prepared in step 1, pour it into a clean glass container, pour the liquid dissolved in step 3 into the Chinese medicine powder in batches, pour 100ml each time, and stir with a stirrer until the Chinese medicine powder is completely dissolved in the liquid and becomes a paste;

[0048] Step 5: Prepare a clean food-grade food-grade fresh-keeping box that can be heated in a microwave oven. Pour the paste-like liquid from step 4 into the fresh-keeping box. Place it in a constant temperature box at 25°C and allow it to cool naturally. After at least 12 hours, take out the fresh-keeping box and cover it with a sealed lid.

[0049] Example 2

[0050] The present embodiment provides a medicine film for relieving the symptoms of knee arthritis that can be used at home, comprising a main ingredient and an auxiliary ingredient. The main ingredient comprises the following raw materials in parts by weight: 50g of Gynostemma pentaphyllum, 50g of Sappan wood, 35g of Conch shell, 30g of processed rhubarb, 50g of Clematidis, 30g of Herba Polygoni Multiflori, 50g of Corydalis yanhusuo, 30g of Licorice, 20g of Asarum, 50g of Millettia reticulata, 60g of Honeysuckle vine and 15g of Lapsang souchong black tea; the auxiliary ingredients comprise 60g of paraffin, 100g of beeswax, 500g of vaseline and 50g of shea butter.

[0051] The specific preparation steps are as follows:

[0052] Step 1: Weigh the main ingredients by weight: 50g of Gynostemma pentaphyllum, 50g of Sappan wood, 35g of Conch shell, 30g of processed rhubarb, 50g of Clematis chinensis, 30g of Herba Polygoni Multiflori, 50g of Corydalis yanhusuo, 30g of Licorice, 20g of Asarum, 50g of Millettia reticulata, 60g of Honeysuckle vine and 15g of Zhengshan Xiaozhong black tea, and mix them together to remove impurities, wash, dry and sterilize; the drying temperature is 50-60℃, and the temperature is repeatedly raised and lowered for 3 hours.

[0053] Step 2: Mix the main ingredients and raw materials into fine powder for later use; the standard of the fine powder is that all powder can pass through a 100-mesh sieve and contain no less than 95% of powder that can pass through a 120-mesh sieve.

[0054] Step 3: Preparation of auxiliary material components, take a clean 1000ml measuring cup, weigh 60g of paraffin and 100g of beeswax, first pour the paraffin and beeswax into the measuring cup, place the measuring cup on a closed electric stove and heat it at 100°C, wait for the paraffin and beeswax to dissolve, then add 500g of vaseline, wait for the vaseline to dissolve completely, reduce the heating temperature of the electric stove to 70°C, finally add 50g of shea butter, until it is completely dissolved, turn off the electric stove, and measure the temperature;

[0055] Step 4: Preparation of the main ingredients: weigh 300g of the Chinese medicine powder prepared in step 1, pour it into a clean glass container, pour the liquid dissolved in step 3 into the Chinese medicine powder in batches, pour 100ml each time, and stir with a stirrer until the Chinese medicine powder is completely dissolved in the liquid and becomes a paste;

[0056] Step 5: Prepare a clean food-grade food-grade fresh-keeping box that can be heated in a microwave oven. Pour the paste-like liquid from step 4 into the fresh-keeping box. Place it in a constant temperature box at 25°C and allow it to cool naturally. After at least 12 hours, take out the fresh-keeping box and cover it with a sealed lid.

[0057] Example 3

[0058] The present embodiment provides a medicine film for relieving the symptoms of knee arthritis that can be used at home, comprising a main ingredient and an auxiliary ingredient. The main ingredient comprises the following raw materials in parts by weight: 25g of Gynostemma pentaphyllum, 30g of Sappan wood, 15g of Conch shell, 10g of processed rhubarb, 20g of Clematidis, 15g of Herba Polygoni Multiflori, 35g of Corydalis yanhusuo, 15g of Licorice, 10g of Asarum, 25g of Millettia reticulata, 25g of Caulis Lonicera japonicae and 25g of Lapsang souchong black tea; the auxiliary ingredients comprise 30g of paraffin, 50g of beeswax, 300g of vaseline and 10g of shea butter.

[0059] The specific preparation steps are as follows:

[0060] Step 1: Weigh the main ingredients of Gynostemma pentaphyllum 25g, Sappan wood 30g, Mountain Conch 15g, Rhubarb 10g, Clematis 20g, Herba Polygoni Multiflori 15g, Corydalis 35g, Licorice 15g, Asarum 10g, Millettia reticulata 25g, Honeysuckle 25g and Lapsang Souchong black tea 25g according to weight, and mix them together to remove impurities, wash, dry and sterilize; the drying temperature is 50-60°C, and the temperature is repeatedly raised and lowered for 3 hours.

[0061] Step 2: Mix the main ingredients and raw materials into fine powder for later use; the standard of the fine powder is that all powder can pass through a 100-mesh sieve and contain no less than 95% of powder that can pass through a 120-mesh sieve.

[0062] Step 3: Preparation of auxiliary material components, take a clean 1000ml measuring cup, weigh 30g of paraffin and 50g of beeswax, first pour the paraffin and beeswax into the measuring cup, place the measuring cup on a closed electric stove and heat it at 100°C, wait for the paraffin and beeswax to dissolve, then add 300g of vaseline, wait for the vaseline to dissolve completely, reduce the heating temperature of the electric stove to 70°C, finally add 10g of shea butter, until it is completely dissolved, turn off the electric stove, and measure the temperature;

[0063] Step 4: Preparation of the main ingredients: weigh 200g of the Chinese medicine powder prepared in step 1, pour it into a clean glass container, pour the liquid dissolved in step 3 into the Chinese medicine powder in batches, pour 100ml each time, and stir with a stirrer until the Chinese medicine powder is completely dissolved in the liquid and becomes a paste;

[0064] Step 5: Prepare a clean food-grade food-grade fresh-keeping box that can be heated in a microwave oven. Pour the paste-like liquid from step 4 into the fresh-keeping box. Place it in a constant temperature box at 25°C and allow it to cool naturally. After at least 12 hours, take out the fresh-keeping box and cover it with a sealed lid.

[0065] Example 4

[0066] The present embodiment provides a medicine film for relieving the symptoms of knee arthritis that can be used at home, comprising a main ingredient and an auxiliary ingredient. The main ingredient comprises the following raw materials in parts by weight: 35g of Gynostemma pentaphyllum, 35g of Sappan wood, 20g of Conch shell, 20g of processed rhubarb, 30g of Clematidis, 30g of Herba Polygoni Multiflori, 45g of Corydalis yanhusuo, 20g of Licorice, 15g of Asarum, 40g of Millettia reticulata, 50g of Honeysuckle vine and 40g of Lapsang souchong black tea; the auxiliary ingredients comprise 60g of paraffin, 100g of beeswax, 350g of vaseline and 50g of shea butter.

[0067] The specific preparation steps are as follows:

[0068] Step 1: Weigh the main ingredients by weight: 35g of Gynostemma pentaphyllum, 35g of Sappan wood, 20g of Conch shell, 20g of processed rhubarb, 30g of Clematis chinensis, 30g of Herba Polygoni Multiflori, 45g of Corydalis yanhusuo, 15-20g of Licorice, 15g of Asarum, 40g of Millettia reticulata, 50g of Honeysuckle vine and 40g of Lapsang souchong black tea; mix them together to remove impurities, wash, dry and sterilize; the drying temperature is 50-60°C, and the temperature is repeatedly raised and lowered for 3 hours.

[0069] Step 2: Mix the main ingredients and raw materials into fine powder for later use; the standard of the fine powder is that all powder can pass through a 100-mesh sieve and contain no less than 95% of powder that can pass through a 120-mesh sieve.

[0070] Step 3: Preparation of auxiliary material components, take a clean 1000ml measuring cup, weigh 60g of paraffin and 100g of beeswax, first pour the paraffin and beeswax into the measuring cup, place the measuring cup on a closed electric stove and heat it, the heating temperature of the electric stove is 100°C, after the paraffin and beeswax are dissolved, add 350g of vaseline, after the vaseline is completely dissolved, the temperature is reduced to 70°C, and finally add 50g of shea butter until it is completely dissolved, turn off the electric stove, and measure the temperature;

[0071] Step 4: Preparation of the main ingredients: weigh 250g of the Chinese medicine powder prepared in step 1, pour it into a clean glass container, pour the liquid dissolved in step 3 into the Chinese medicine powder in batches, pour 100ml each time, and stir with a stirrer until the Chinese medicine powder is completely dissolved in the liquid and becomes a paste;

[0072] Step 5: Prepare a clean food-grade food-grade fresh-keeping box that can be heated in a microwave oven. Pour the paste-like liquid from step 4 into the fresh-keeping box. Place it in a constant temperature box at 25°C and allow it to cool naturally. After at least 12 hours, take out the fresh-keeping box and cover it with a sealed lid.

[0073] Example 5

[0074] The present embodiment provides a medicine film for relieving the symptoms of knee arthritis that can be used at home, comprising a main ingredient and an auxiliary ingredient. The main ingredient comprises the following raw materials in parts by weight: 30 g of Gynostemma pentaphyllum, 20 g of Sappan wood, 10 g of Conch shell, 10 g of processed rhubarb, 10 g of Clematidis, 10 g of Herba Polygoni Multiflori, 20 g of Corydalis yanhusuo, 10 g of Licorice, 9 g of Asarum, 10 g of Millettia reticulata, 15 g of Honeysuckle vine and 20 g of Lapsang souchong black tea; the auxiliary ingredient comprises 30 g of paraffin, 50 g of beeswax, 300 g of vaseline and 10 g of shea butter.

[0075] The specific preparation steps are as follows:

[0076] Step 1: Weigh the main ingredients according to weight: 30g of Gynostemma pentaphyllum, 20g of Sappan wood, 10g of Conch shell, 10g of processed rhubarb, 10g of Clematis chinensis, 10g of Herba Polygoni Multiflori, 20g of Corydalis yanhusuo, 10g of Licorice, 9g of Asarum, 10g of Millettia reticulata, 15g of Honeysuckle vine and 20g of Zhengshan Xiaozhong black tea, and mix them together to remove impurities, wash, dry and sterilize; the drying temperature is 50-60℃, and the temperature is repeatedly raised and lowered for 3 hours.

[0077] Step 2: Mix the main ingredients and raw materials into fine powder for later use; the standard of the fine powder is that all powder can pass through a 100-mesh sieve and contain no less than 95% of powder that can pass through a 120-mesh sieve.

[0078] Step 3: Preparation of auxiliary material components, take a clean 1000ml measuring cup, weigh 30g of paraffin and 50g of beeswax, first pour the paraffin and beeswax into the measuring cup, place the measuring cup on a closed electric stove and heat it at 100°C, wait for the paraffin and beeswax to dissolve, then add 300g of vaseline, wait for the vaseline to dissolve completely, lower the heating temperature of the electric stove to 70°C, finally add 10g of shea butter, until it is completely dissolved, and turn off the electric stove;

[0079] Step 4: Preparation of the main ingredients: weigh 150g of the Chinese medicine powder prepared in step 1, pour it into a clean glass container, pour the liquid dissolved in step 3 into the Chinese medicine powder in batches, pour 100ml each time, and stir with a stirrer until the Chinese medicine powder is completely dissolved in the liquid and becomes a paste;

[0080] Step 5: Prepare a clean food-grade food-grade fresh-keeping box that can be heated in a microwave oven. Pour the paste-like liquid from step 4 into the fresh-keeping box. Place it in a constant temperature box at 25°C and allow it to cool naturally. After at least 12 hours, take out the fresh-keeping box and cover it with a sealed lid.

[0081] Example 6

[0082] The present embodiment provides a medicine film for relieving the symptoms of knee arthritis that can be used at home, comprising a main ingredient and an auxiliary ingredient. The main ingredient comprises the following raw materials in parts by weight: 30 g of Gynostemma pentaphyllum, 35 g of Sappan wood, 26 g of Conch shell, 20 g of processed rhubarb, 25 g of Clematidis, 20 g of Herba Polygoni Multiflori, 35 g of Corydalis yanhusuo, 20 g of Licorice, 14 g of Asarum, 30 g of Millettia reticulata, 40 g of Honeysuckle vine and 32 g of Lapsang souchong black tea; the auxiliary ingredients comprise 45 g of paraffin, 75 g of beeswax, 350 g of Vaseline and 25 g of shea butter.

[0083] The specific preparation steps are as follows:

[0084] Step 1: Weigh the main ingredients according to weight: 30g of Gynostemma pentaphyllum, 35g of Sappan wood, 26g of Conch shell, 20g of processed rhubarb, 25g of Clematis chinensis, 20g of Herba Polygoni Multiflori, 35g of Corydalis yanhusuo, 20g of Licorice root, 14g of Asarum, 30g of Millettia reticulata, 40g of Honeysuckle vine and 32g of Zhengshan Xiaozhong black tea, and mix them together to remove impurities, wash, dry and sterilize; the drying temperature is 50-60℃, and the temperature is repeatedly raised and lowered for 3 hours.

[0085] Step 2: Mix the main ingredients and raw materials into fine powder for later use; the standard of the fine powder is that all powder can pass through a 100-mesh sieve and contain no less than 95% of powder that can pass through a 120-mesh sieve.

[0086] Step 3: Preparation of auxiliary material components, take a clean 1000ml measuring cup, weigh 45g of paraffin and 75g of beeswax, first pour the paraffin and beeswax into the measuring cup, place the measuring cup on a closed electric stove and heat it at 100°C, wait for the paraffin and beeswax to dissolve, then add 350g of vaseline, wait for the vaseline to dissolve completely, reduce the heating temperature of the electric stove to 70°C, finally add 25g of shea butter, until it is completely dissolved, and turn off the electric stove;

[0087] Step 4: Preparation of the main ingredients: weigh 200g of the Chinese medicine powder prepared in step 1, pour it into a clean glass container, pour the liquid dissolved in step 3 into the Chinese medicine powder in batches, pour 100ml each time, and stir with a stirrer until the Chinese medicine powder is completely dissolved in the liquid and becomes a paste;

[0088] Step 5: Prepare a clean food-grade food-grade fresh-keeping box that can be heated in a microwave oven. Pour the paste-like liquid from step 4 into the fresh-keeping box. Place it in a constant temperature box at 25°C and allow it to cool naturally. After at least 12 hours, take out the fresh-keeping box and cover it with a sealed lid.

[0089] Example 7

[0090] The present embodiment provides a medicine film for relieving the symptoms of knee arthritis that can be used at home, comprising a main ingredient and an auxiliary ingredient. The main ingredient comprises the following raw materials in parts by weight: 30 g of Gynostemma pentaphyllum, 32 g of Sappan wood, 17 g of Conch shell, 15 g of processed rhubarb, 25 g of Clematidis, 20 g of Herba Polygoni Multiflori, 40 g of Corydalis, 17 g of Licorice, 32 g of Asarum, 37 g of Millettia reticulata, 37 g of Honeysuckle vine and 27 g of Lapsang souchong black tea; the auxiliary ingredient comprises 30 g of paraffin, 50 g of beeswax, 300 g of vaseline and 10 g of shea butter.

[0091] The specific preparation steps are as follows:

[0092] Step 1: Weigh the main ingredients according to weight: 30g of Gynostemma pentaphyllum, 32g of Sappan wood, 17g of Conch shell, 15g of processed rhubarb, 25g of Clematis chinensis, 20g of Herba Polygoni Multiflori, 40g of Corydalis yanhusuo, 17g of Licorice root, 32g of Asarum, 37g of Millettia reticulata, 37g of Honeysuckle vine and 27g of Zhengshan Xiaozhong black tea, and mix them together to remove impurities, wash, dry and sterilize; the drying temperature is 50-60℃, and the temperature is repeatedly raised and lowered for 3 hours.

[0093] Step 2: Mix the main ingredients and raw materials into fine powder for later use; the standard of the fine powder is that all powder can pass through a 100-mesh sieve and contain no less than 95% of powder that can pass through a 120-mesh sieve.

[0094] Step 3: Preparation of auxiliary material components, take a clean 1000ml measuring cup, weigh 30g of paraffin and 50g of beeswax, first pour the paraffin and beeswax into the measuring cup, place the measuring cup on a closed electric stove and heat it at 100°C, wait for the paraffin and beeswax to dissolve, then add 300g of vaseline, wait for the vaseline to dissolve completely, lower the heating temperature of the electric stove to 70°C, finally add 10g of shea butter, until it is completely dissolved, and turn off the electric stove;

[0095] Step 4: Preparation of the main ingredients: weigh 300g of the Chinese medicine powder prepared in step 1, pour it into a clean glass container, pour the liquid dissolved in step 3 into the Chinese medicine powder in batches, pour 100ml each time, and stir with a stirrer until the Chinese medicine powder is completely dissolved in the liquid and becomes a paste;

[0096] Step 5: Prepare a clean food-grade food-grade fresh-keeping box that can be heated in a microwave oven. Pour the paste-like liquid from step 4 into the fresh-keeping box. Place it in a constant temperature box at 25°C and allow it to cool naturally. After at least 12 hours, take out the fresh-keeping box and cover it with a sealed lid.

[0097] Experimental Example 1

[0098] The drug films of different proportions in Examples 1-7 were used to treat KOA patients respectively, and the knee joint function score (Lysholm) before and after treatment was compared; the scoring system consists of 8 questions, with a score of 0-100 points, and the higher the score, the better the patient's functional state; compared with other scoring scales, the Lysholm score is more inclined to daily life activities. The comparison results of the Lysholm score before and after treatment of Examples 1-7 are shown in Table 1:

[0099] Table 1

[0100]

[0101]

[0102] Compared with the same group before and after treatment, *P<0.001; compared with Example 1 and other groups, ▲P<0.05 (0.02, 0.04, 0.01, 0.044, 0.003, 0.016)

[0103] According to Table 1, after the KOA patients were treated with the medicine films of different ratios prepared in Examples 1-7, the Lysholm scores increased significantly, indicating that the medicine films prepared by this scheme can significantly improve the knee joint function, and the medicine films prepared by using 35g of Gynostemma pentaphyllum, 20g of Sappan wood, 25g of Conch shell, 20g of processed rhubarb, 25g of Clematis chinensis, 25g of Radix Angelicae Pubescentis, 20g of Corydalis yanhusuo, 15g of Licorice, 15g of Asarum, 30g of Millettia reticulata, 30g of Lonicera japonica and 20g of Lapsang souchong black tea; the auxiliary ingredients include 80g of paraffin, 40g of beeswax, 300g of vaseline and 30g of shea butter have a more obvious effect.

[0104] Experimental Example 2

[0105] In a certain outpatient department, 82 cases of knee osteoarthritis in the elderly were selected and randomly divided into a warm needle group and a drug film group. In the warm needle group, there were 15 males and 26 females, aged 55 to 80 years old, with an average age of 65.73±6.13 years old, and the course of disease was 9 months to 96 months, with an average course of disease of 36.61±21.19 months; in the drug film group, there were 17 males and 24 females, aged 55 to 79 years old, with an average age of 65.80±7.15 years old, and the course of disease was 12-96 months, with an average course of disease of 33.83±21.65 months. The average age of the two groups was compared, and the P value was 0.149; the average course of disease of the two groups was compared, and the P value was 0.811, and the P values ​​were all <0.05. There was no significant difference in age and course of disease between the two groups.

[0106] Inclusion criteria: ① Meet the diagnosis of knee osteoarthritis and traditional Chinese medicine knee arthritis; ② Have good cognitive function and can cooperate with the entire course of treatment; ③ Negative floating patella test; ④ Age over 55 years old; ⑤ Know the content of the study and agree to participate.

[0107] Exclusion criteria: ① patients with knee osteoarthritis who have indications for surgical treatment; ② patients with violent mental illness; ③ terminally ill patients; ④ patients with concomitant infectious diseases who need to be isolated; ⑤ patients who have received similar treatment recently; ⑥ patients with skin ulcers in the knee joint; ⑦ patients with retreated knee osteoarthritis.

[0108] Treatment

[0109] Warm needle group: select the inner and outer knee eye, Zusanli, Liangqiu, Xuehai, and Yinlingquan acupoints on the affected side. The patient is in supine position and a 0.3mm×40mm disposable sterile acupuncture needle is selected. The needle and skin surface are disinfected, the acupoints are pierced directly, and the twisting technique is performed. After getting the qi, the inner and outer knee eye acupoints are selected for warm acupuncture. The acupoints are separated by thin cardboard, and a 3cm moxibustion stick is selected and inserted into the needle handle. The moxa stick is lit and moxibustion is performed. Each point is moxibustioned twice, and the needle is retained for 30 minutes. 3 times a week, 4 weeks as a course of treatment.

[0110] The drug film group: The drug film prepared by the components of Example 1 was used for hot compress. The first two weeks were in the outpatient clinic and the method was learned. The hot compress was performed at home for the next two weeks and the outpatient clinic telephone follow-up was performed. Three times a week, one box of drug film can be used for 6 times for one knee joint. Two boxes of drug film were prepared for each course of treatment, and one course of treatment lasted for 4 weeks.

[0111] Observation indicators:

[0112] (1) Efficacy indicators

[0113] The efficacy judgment criteria of this study were formulated by referring to the efficacy evaluation criteria of the "Guidelines for Clinical Diagnosis and Treatment of Knee Osteoarthritis in Traditional Chinese Medicine Orthopedics" and combining the patients' pain relief and knee joint function recovery.

[0114] Clinical cure: knee pain completely disappears and knee joint function is normal;

[0115] Significant effect: Slight pain in the knee joint, which does not affect the normal activities of the knee joint, but the pain is slightly aggravated when the activity is excessive; Improved: Slightly obvious pain in the knee joint, but does not affect the normal activities of the knee joint;

[0116] Ineffective: The knee joint pain was not significantly relieved and the knee joint could not move normally.

[0117] Total effective rate = (total number of cases - ineffective cases) / total number of cases × 100%.

[0118] (2) VAS score

[0119] The VAS score is a pain rating scale that uses a visual analogue method to judge the severity of pain. The rating standard is divided into 10 equal parts using a ruler, with 0 being no pain, 1-3 being mild pain, 4-6 being moderate pain, and 7-10 being severe pain.

[0120] (3) WOMAC Osteoarthritis Index

[0121] The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Osteoarthritis Index) was used. The entire scale covers three dimensions: pain (5 items), stiffness (2 items), and joint function (17 items). Each item option is assigned 1 to 5 points according to the severity. The changes in knee pain, morning stiffness, and range of motion were observed before and after treatment. The higher the score, the more severe the condition.

[0122] This rating scale effectively reflects the conditions before and after treatment, such as patient satisfaction, and is a widely used assessment scale for OA patients.

[0123] (4) Recurrence rate

[0124] Follow-up was conducted at 3 and 6 months after treatment, and the number of cases in which the effective results became ineffective after treatment was regarded as the number of recurrences.

[0125] Treatment Outcomes

[0126] (1) According to the efficacy evaluation criteria and combined with the patients' pain relief and knee joint function recovery, the comparison between the drug film group and the warm needle group is shown in Table 2.

[0127] Table 2

[0128] Group Number of people participating in treatment cure Significant effect Improvement invalid Total Effectiveness Warm needle group 41 4 19 10 8 80.49％ Film group 41 6 20 10 5 87.80％

[0129] Note: χ2 value is 4.267, P value is 0.833*

[0130] After one course of treatment in the warm needle group, 4 cases were cured, 19 cases showed marked effect, 10 cases improved, 8 cases were ineffective, and the total effective rate was 80.49%; after one course of treatment in the warm needle combined with medicine film group, 6 cases were cured, 20 cases showed marked effect, 10 cases improved, 5 cases were ineffective, and the total effective rate was 87.80%; compared with the two groups, the efficacy of the medicine film group was higher than that of the warm needle group (P>0.05).

[0131] (2) According to the VAS value for quantifying pain, the comparison between the drug film group and the warm needle group is shown in Table 3.

[0132] Table 3

[0133] Group Number of people participating in treatment Before treatment After treatment t-value P-value Warm needle group 41 7.61±1.05 3.54±2.10 12.406 0.000* Film group 41 7.41±1.20 2.71±2.00 20.498 0.000*

[0134] Compared with before treatment, *P<0.001; compared with the warm needling group after treatment, P value was 0.071.

[0135] One course after treatment, the warm needle group scored 3.54±2.10 points, which was significantly different from 7.61±1.05 points before treatment (P<0.001); the drug film group scored 7.41±1.20 points before treatment and 2.71±2.00 points after treatment, with significant difference before and after treatment. Comparing the two groups, the t value of the warm needle group was 12.406, and the t value of the drug film group was 20.498. It can be clearly seen that the drug film group had better therapeutic effect.

[0136] Figure 1 The difference in VAS before and after treatment between the acupuncture group and the medicine film group was more intuitive, and the VAS value of the medicine film group decreased more significantly after treatment.

[0137] (3) Comparison of the WOMAC osteoarthritis index between the drug film group and the warm needle group is shown in Table 4.

[0138] Table 4

[0139]

[0140] Compared with the same group before treatment, *P<0.001; compared with the warm needling group after treatment, ▲P<0.05 (0.679, 0.578, 0.019)

[0141] One course of treatment, both the warm needle group and the drug film group showed improvements in pain, stiffness and joint function. The drug film group effectively improved the pain, stiffness and activity function symptoms of the elderly's knee joints (P < 0.001); the drug film group was significantly better than the warm needle group in relieving the activity function of the knee joint (P < 0.05).

[0142] (4) The recurrence rates were compared at 3 and 6 months after treatment, as shown in Table 5.

[0143] Table 5

[0144] Group Number of people participating in treatment 3 months after treatment 6 months after treatment Relapse rate Warm needle group 33 3(9.09) 4(12.12) 21.21 Film group 36 1(2.78) 2(5.56) 8.33

[0145] Compared with before treatment, *P<0.001

[0146] In the follow-up 3 and 6 months after treatment, the recurrence rates of the warm needle group were 9.09% and 12.12% respectively, and the total recurrence rate was 21.21%; the warm needle combined with drug film group were 2.78% and 5.56% respectively, and the total recurrence rate was 8.33%. The recurrence rate of the drug film group was significantly lower than that of the warm needle group.

[0147] In summary, the medicine film for relieving the symptoms of knee arthritis prepared by the raw material formula of the present invention comprises gynostemma pentaphyllum, sappan wood, mountain conch, processed rhubarb, clematis root, radix spatholobi, corydalis yanhusuo, liquorice, asarum, millettia spatholobi, honeysuckle vine and lapsang souchong black tea as the main ingredients. Sappan wood has the effects of promoting qi, promoting blood circulation, removing blood stasis, reducing swelling and relieving pain; mountain conch has the effects of clearing away heat, reducing swelling, detoxifying and discharging pus; clematis root has the effects of removing rheumatism and unblocking meridians; radix spatholobi has the effects of relaxing muscles and promoting blood circulation, dispersing blood stasis and reducing swelling, detoxifying and relieving pain ; Yuanhusuo has the effects of promoting blood circulation, removing blood stasis, promoting qi and relieving pain; Millettia reticulata has the effects of relaxing muscles and tendons, promoting blood circulation, replenishing blood and relieving pain; Honeysuckle has the effects of clearing away heat and detoxifying, dispersing wind and relieving pain; Zhengshan Xiaozhong black tea has the effects of anti-inflammatory, diuretic and swelling reduction; Asarum has the effects of dispersing cold, dispelling wind and relieving pain. After the main ingredients are used in a certain proportion, they can effectively disperse the blood stasis in the human body; disperse the stagnation and reduce swelling, promote blood circulation and remove blood stasis, relieve pain, promote blood circulation, improve the stasis state of local tissues, and dredge the meridians.

[0148] Although the preferred embodiments of the present application have been described, those skilled in the art may make additional changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications falling within the scope of the present application.

Claims

1. A medicine film for relieving the symptoms of knee arthritis that can be used at home, comprising a main ingredient and an auxiliary ingredient, characterized in that: The main ingredients are composed of the following raw materials in parts by weight: 10-50g of Gynostemma pentaphyllum, 20-50g of Sappan wood, 10-35g of Conch shell, 10-30g of processed rhubarb, 10-50g of Clematis chinensis, 10-30g of Herba Polygoni Multiflori, 20-50g of Corydalis yanhusuo, 10-30g of Licorice root, 9-20g of Asarum, 10-50g of Millettia reticulata, 15-60g of Honeysuckle vine and 15-50g of Lapsang souchong black tea; the auxiliary ingredients include vaseline, paraffin and beeswax.

2. A medical film for relieving knee arthritis symptoms that can be used at home according to claim 1, characterized in that: The main ingredients are composed of the following raw materials in parts by weight: Ingredients: 25-35g of Gynostemma pentaphyllum, 30-35g of Sappan wood, 15-20g of mountain conch, 10-20g of processed rhubarb, 20-30g of Clematis chinensis, 15-30g of Radix Polygoni Multiflori, 35-45g of Corydalis yanhusuo, 15-20g of Licorice, 10-15g of Asarum, 25-40g of Millettia reticulata, 25-50g of Honeysuckle vine and 20-35g of Lapsang souchong black tea.

3. A medical film for relieving knee arthritis symptoms that can be used at home according to claim 1, characterized in that: The auxiliary material component is composed of the following raw materials in parts by weight: 30-60 g of paraffin, 50-100 g of beeswax, 300-500 g of vaseline and 10-50 g of shea butter.

4. The method for preparing a drug film for relieving knee arthritis symptoms that can be used at home according to any one of claim 3, characterized in that: The specific preparation steps are as follows: Step 1: weigh the main ingredients according to weight: 10-50g of Gynostemma pentaphyllum, 20-50g of Sappan wood, 10-35g of Conch shell, 10-30g of processed rhubarb, 10-50g of Clematis chinensis, 10-30g of Radix Angelicae Pubescentis, 20-50g of Corydalis yanhusuo, 10-30g of Licorice root, 9-20g of Asarum, 10-50g of Millettia reticulata, 15-60g of Honeysuckle vine and 15-50g of Lapsang souchong black tea, and mix them together to remove impurities, wash, dry and sterilize; Step 2: Mix the main ingredients and grind them into fine powder for later use; Step 3: Preparation of auxiliary material components, take a clean 1000ml measuring cup, weigh 30-60g of paraffin and 50-100g of beeswax, first pour the paraffin and beeswax into the measuring cup, place the measuring cup on a closed electric stove and heat, after the paraffin and beeswax are dissolved, add 300-500g of vaseline, after the vaseline is completely dissolved, finally add 10-50g of shea butter, until it is completely dissolved, and turn off the electric stove; Step 4: Preparation of the main ingredients: weigh 150-500g of the reserved Chinese medicine powder in step 2, pour it into a clean glass container, pour the dissolved liquid in step 3 into the Chinese medicine powder in batches, and stir with a stirrer until the Chinese medicine powder is completely dissolved in the liquid and becomes a paste; Step 5: Prepare a clean, microwaveable food-grade fresh-keeping box, pour the paste from step 4 into the box, put it in a constant temperature box, and let it cool naturally. After at least 12 hours, take out the box and cover it with a sealed lid.

5. The method for preparing a drug film for relieving knee arthritis symptoms that can be used at home according to claim 4, characterized in that: In step 1, the drying temperature is 50-60°C, and the temperature is repeatedly raised and lowered for 3 hours.

6. The method for preparing a drug film for relieving knee arthritis symptoms that can be used at home according to claim 4, characterized in that: In step 2, the standard of the fine powder refers to that the fine powder can all pass through a 100-mesh sieve, and contains no less than 95% of the powder that can pass through a 120-mesh sieve.

7. The method for preparing a drug film for relieving knee arthritis symptoms that can be used at home according to claim 4, characterized in that: In step 3, the temperature of the electric furnace is 100° C. when the paraffin, beeswax and vaseline are dissolved.

8. The method for preparing a drug film for relieving knee arthritis symptoms that can be used at home according to claim 4, characterized in that: In step 3, the temperature of the electric furnace is 70°C when the shea butter is dissolved.

9. The method for preparing a drug film for relieving knee arthritis symptoms that can be used at home according to claim 4, characterized in that: In step 4, pour 100 ml of the liquid containing the dissolved auxiliary materials each time.

10. The method for preparing a drug film for relieving knee arthritis symptoms that can be used at home according to claim 4, characterized in that: In step 5, the temperature of the thermostat is 25°C.

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