Polymer microparticles and their preparation method and application

By cross-linking rigid nanoparticles to form orderly arranged porous polymer particles, the problems of uncontrollable pore size and insufficient mechanical properties of polysaccharide gel balls in chromatographic separation are solved, and efficient and low-cost biological protein separation is achieved.

CN116554536BActive Publication Date: 2025-10-03JIANGSU JICUI INTELLIGENT LCD TECH CO LTD
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Patent Information

Application Number
CN202210098560.X
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-01-27
Publication Date
2025-10-03
Estimated Expiration
2042-01-27

AI Technical Summary

Technical Problem

Existing polysaccharide gel spheres cannot control the internal pore structure in chromatographic separations and have insufficient mechanical properties, resulting in poor separation effects. In addition, the raw material cost is high, making large-scale industrial production difficult.

Method used

Rigid nanoparticles are cross-linked to form porous polymer microparticles. The nanoparticles have a non-spherically symmetrical shape in the solution, locally forming a basically ordered arrangement structure, and the pore structure is also correspondingly ordered, combined with polysaccharide compounds to provide structural support.

Benefits of technology

It improves the separation effect and efficiency of chromatographic separation, reduces costs, has good mechanical properties and biocompatibility, and is suitable for high-efficiency biological protein separation.

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Abstract

The present application relates to a polymer microparticle, a preparation method, and an application thereof. The polymer microparticle is formed by cross-linking at least partially cross-linkable polymer materials including rigid nanoparticles, wherein at least one rigid nanoparticle has a non-spherically symmetric shape in solution, and the rigid nanoparticles at least partially form a substantially ordered arrangement structure 5 in the polymer microparticle. The polymer microparticles disclosed in the present application, when used as a stationary phase for chromatographic separation, have excellent mechanical properties and good biocompatibility, and can effectively improve the separation effect.
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Citation Information

Patent Citations

  • Porous cellulose microparticles and methods of manufacture thereof

    WO2020227816A1