Research and Development Equipment for a Drug for Treating Lung Injury

Abstract

The present invention belongs to the technical field of equipment for drug research and development, and particularly relates to a research and development device for drugs for treating lung injury, including an outer box body, on which an air injection hole and an exhaust hole are provided; inside the bottom box, there is an animal breeding box, which includes a first box body and a second box body. The first box body includes a three-dimensional structure with one side open, which is formed by splicing side plates, a top plate, a bottom plate, a front plate and a rear plate. The first box body and the second box body are rotatably connected to both ends of a handle, and a locking switch is installed on the handle to control the deformation of the first box body and the second box body through the locking switch. The present invention provides a research and development device for drugs for treating lung injury. This research and development device can be applied to the research and development of drugs for treating lung injury, can meet the needs of animals' free movement and fixing animals, and facilitates the operation of experimental personnel.

Description

Technical Field

[0001] The present invention belongs to the technical field of equipment for drug research and development, and particularly relates to a research and development device for drugs for treating lung injury. Background Art

[0002] Drug research and development is an important link beneficial to the health of organisms such as animals and humans. The general process of new drug research and development is as follows: (1) determination of the action site, which includes the target site of drug treatment and is directly related to the type of disease, such as treating lung injury, pharyngitis, etc.; (2) screening of candidate drugs, analyzing the relationship between the action target and the chemical properties of the compound / composition, and screening out some products such as compounds / compositions with disease treatment efficacy; (3) experimental stage, conducting animal tests such as toxicological tests and clinical trials on the screened drugs to determine the products with better efficacy.

[0003] In the process of the above new drug research and development, animal tests are an essential step. Generally speaking, when conducting animal tests, two types of experimental groups, namely the animal model group and the blank group, will be set up. The animal model group needs to be treated first to cause disease injury to the animals, and then drugs are given to the animals. By comparing the physiological indexes of the animals in the model group and the blank group after drug administration, the toxicity, efficacy, etc. of the drugs are evaluated.

[0004] In the process of constructing animal models, some reagents are directly administered by gavage, some are injected, and some are inhaled. Taking the lung injury animal model as an example, inhaled reagents or external stimuli are used to expose the animals to a specific environment. For example, a device for making a chronic hyperoxic lung injury model disclosed in Chinese Patent CN115778617A includes: a box body, a cover body, a mouse breeding box, a central control box, an oxygen generator, and an oxygen monitoring sensor. Compared with traditional production boxes, the device of this patent can adjust the oxygen concentration to maintain a stable high concentration state, and the animal model can greatly shorten the production process of the chronic hyperoxic lung injury model in this temperature environment. Another example is a device for constructing a blast-induced lung injury animal model disclosed in Chinese Patent CN218164031U, which includes a pressure test part, a counterweight seat arranged on the lower side of the pressure test part, and an air compressor connected to the pressure test part through a high-pressure pipe. The device for constructing a blast-induced lung injury animal model provided by this patent uses the control of air pressure to replace the use of TNT, and uses air pressure impact to simulate the explosion air wave, so that the simulation experiment can be completed more safely, effectively reducing the cost and risk of the experiment, and better protecting the safety of the operators.

[0005] The above-mentioned existing technology patents provide better exposure devices, which are beneficial to the construction of animal models with lung injury and can cooperate well with drug research and development. However, there is a common problem with the above-mentioned existing technologies. The box structure for raising animals is immutable. The animals can move freely in the exposure device. When the animals need to be taken out, it is not easy to grab the animals in the active state. Moreover, when detecting the physiological indexes of the animals subsequently, the animals need to be fixed before sampling, resulting in inconvenient operation. Therefore, it is necessary to develop a device suitable for the research and development of drugs for the treatment of lung injury to meet the needs of animal free movement and animal fixation. Summary of the Invention

[0006] In order to solve the above technical problems, the present invention provides a research and development device for drugs for the treatment of lung injury. This research and development device is applicable to the research and development of drugs for the treatment of lung injury, can meet the needs of animal free movement and animal fixation, and facilitates the operation of experimental personnel.

[0007] The purpose of the present invention is to provide a research and development device for drugs for the treatment of lung injury, including an outer box body. The outer box body includes a bottom box and a box cover, and an air injection hole and an exhaust hole are provided on the outer box body;

[0008] An animal breeding box is arranged inside the bottom box. The animal breeding box includes a first box body and a second box body. The first box body includes a three-dimensional structure with one side open formed by splicing side plates, a top plate, a bottom plate, a front plate and a rear plate. The side plates, the top plate and the bottom plate are all mesh structure plates. The top plate and the bottom plate are respectively rotatably connected to both ends of the side plates. The front plate and the rear plate are both made of elastic materials. The first box body and the second box body have the same structure and are arranged oppositely;

[0009] The first box body and the second box body are rotatably connected to both ends of a handle, and a locking switch is installed on the handle. The deformation of the first box body and the second box body is controlled by the locking switch.

[0010] Preferably, for the above-mentioned research and development device for drugs for the treatment of lung injury, the locking switch includes a front magnetic attraction switch and a rear magnetic attraction switch. The front magnetic attraction switch and the rear magnetic attraction switch are both installed between the first box body and the second box body. The front magnetic attraction switch and the rear magnetic attraction switch can both be separated up and down. The control buttons of the rear magnetic attraction switch and the control buttons of the front magnetic attraction switch are both installed on the handle.

[0011] Preferably, for the above-mentioned research and development device for drugs for the treatment of lung injury, it further includes a switch board. The control buttons of the rear magnetic attraction switch and the control buttons of the front magnetic attraction switch are both installed on the switch board, and the switch board is installed on the handle.

[0012] Preferably, for the R & D equipment of the above-mentioned lung injury treatment drug, the handle is of a hollow structure, and the locking switch includes a front switch, a rear switch and a connecting strip;

[0013] The front switch includes an upper tube, a lower tube and a pressing plate. Both the upper tube and the lower tube are arranged between the front plate of the first box body and the front wall plate of the second box body. The lower tube is sleeved inside the lower end of the upper tube in a vertically movable manner. A connecting plate is arranged above the lower tube inside the upper tube, and a through hole is opened on the connecting plate;

[0014] The front switch and the rear switch have the same structure and are symmetrically arranged on both sides of the handle along the length direction;

[0015] The upper tubes of the front switch and the rear switch are both connected to the handle. The connecting strip is arranged inside the handle. The end of the connecting strip can penetrate through the through hole of the upper tube and the connecting plate on the same side as it, and is finally fixedly connected to the top of the lower tube on the same side as it. The pressing plate movably penetrates through the top of the handle.

[0016] Preferably, for the R & D equipment of the above-mentioned lung injury treatment drug, the connecting strip is an elastic strip, which has both rigidity and bending ability.

[0017] Preferably, for the R & D equipment of the above-mentioned lung injury treatment drug, a connecting rope is arranged between the connecting strip and the lower tube.

[0018] Preferably, for the R & D equipment of the above-mentioned lung injury treatment drug, magnetic components that attract each other are arranged between the lower tube and the connecting plate.

[0019] Preferably, for the R & D equipment of the above-mentioned lung injury treatment drug, a feeding trough is arranged inside the animal breeding box.

[0020] Preferably, for the R & D equipment of the above-mentioned lung injury treatment drug, the bottom surface and the lower end of the side surface of the animal breeding box are set as closed structures.

[0021] Preferably, for the R & D equipment of the above-mentioned lung injury treatment drug, the inside of the bottom box is divided into multiple test areas by a partition board, and a plurality of ventilation holes are opened on the partition board.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] 1. Under the inventive concept of this embodiment, the animal breeding box is used to breed animals, and the animals can move inside the animal breeding box. The R & D equipment we designed can meet the needs of both the free movement of animals and the fixation of animals, and can also meet the construction of animal models with lung injuries. It has multiple functions and is easy to operate. When the animal breeding box is placed naturally on the experimental table, it has a cuboid structure. When the handle is lifted to suspend the animal breeding box, the locking switch is triggered, and the width of the animal breeding box becomes shorter. Then the animals inside the animal breeding box are clamped, thus fixing the animals. At this time, if an elastic sleeve is used to cover the outside of the animal breeding box, the fixation effect of the animals will be better. If it is necessary to release the animals to move freely again, the animal breeding box is placed inside the outer box body or on the experimental tabletop for subsequent experiments. When the handle and the locking switch are released, under the action of gravity and magnetic attraction, the animal breeding box returns to its previous cuboid structure.

[0024] 2. The present invention provides multiple structural embodiments of the locking switch. Different structures have both similarities and differences in functions, and the structures are diverse.

[0025] 3. In one embodiment of the present invention, the bottom surface and the lower ends of the sides of the animal breeding box are set as closed structures, so that excreta such as urine and feces of the animals can be collected by the bottom of the animal breeding box.

[0026] 4. In one embodiment of the present invention, the inner part of the bottom box is divided into multiple test areas by partitions, and multiple animal tests can be carried out simultaneously, with high efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a three-dimensional structural schematic diagram of the R & D equipment for drugs for treating lung injuries in Embodiment 1 of the present invention.

[0028] Figure 2 It is a structural schematic diagram of the animal breeding box in Embodiment 1 of the present invention when it is not lifted.

[0029] Figure 3 It is a structural schematic diagram of the animal breeding box in Embodiment 1 of the present invention after it is lifted.

[0030] Figure 4 It is a longitudinal sectional structural schematic diagram of the animal breeding box in Embodiment 2 of the present invention when it is not lifted.

[0031] Figure 5 It is a structural schematic diagram of the animal breeding box in Embodiment 2 of the present invention when it is not lifted.

[0032] Figure 6 It is a longitudinal sectional structural schematic diagram of the animal breeding box in Embodiment 2 of the present invention when it is lifted.

[0033] Figure 7 It is a structural schematic diagram of the animal breeding box in Embodiment 2 of the present invention when it is lifted.

[0034] Figure 8 This is a schematic structural diagram of the bottom box in Embodiment 4 of the present invention. Detailed implementation manners

[0035] In order to enable those skilled in the art to better understand and implement the technical solutions of the present invention, the present invention will be further described below in conjunction with specific embodiments and the accompanying drawings.

[0036] In the description of the present invention, unless otherwise specified, the reagents used are all commercially available, and the methods used are all conventional techniques in the art.

[0037] In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present invention.

[0038] The terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include one or more of such features; in the description of the present invention, unless otherwise stated, the meaning of "plurality" is two or more.

[0039] Embodiment 1

[0040] A research and development device for a drug for treating lung injury, see Figure 1-3 , including an outer box body 1. The inside and outside of the outer box body 1 are isolated. The inside of the outer box body 1 is a place with an exposure environment, and the outside of the outer box body 1 is in normal environmental conditions. The outer box body 1 isolates the special exposure environment from the normal environmental conditions, and the external experimenters are in a safe state. The outer box body 1 includes a bottom box 11 and a box cover 12. Preferably, both the bottom box 11 and the box cover 12 are made of transparent materials for convenient observation of animals. The upper end of the bottom box 11 is open, and the other surfaces are closed surfaces. The lower end of the box cover 12 is open, and the other surfaces are closed surfaces. A sealing strip is provided on the inner wall of the box cover 12. When the box cover 12 is closed on the bottom box 11, the sealing strip is located between the inner wall of the box cover 12 and the upper outer wall of the bottom box 11 to seal the connection between the box cover 12 and the bottom box 11 and prevent air leakage. The transparent bottom box 11 and the transparent box cover 12 facilitate observing the inside of the outer box body 1.

[0041] An air injection hole is provided on the lid 12 or the bottom box 11. The air injection hole is used to inject an inhalable reagent that can cause animal lung injury, such as poisonous gas. After the animal is exposed to the inhalable reagent environment that causes animal lung injury for a long time, it will cause lung injury, and finally a lung injury animal model is made. Drug tests can also be carried out in the outer box body 1. The model group does not take drugs, and another treatment group that takes drugs is set up. By observing the physiological indexes and animal reactions of different groups, the curative effect of the drug is evaluated to carry out the research and development of drugs for the treatment of lung injury. If the animal model is constructed and the animal is continuously administered drugs, and the special poisonous gas is continuously exposed in the outer box body 1, the resistance of the animal to the poisonous gas environment after taking the drug can also be evaluated.

[0042] An exhaust hole is also provided on the lid 12 or the bottom box 11. A exhaust pipe is connected to the exhaust hole. The edge of the exhaust hole is connected to the edge of the exhaust pipe, and the connection part is coated with sealant to prevent air leakage. The end of the exhaust pipe that is not connected to the exhaust hole is connected to the waste gas treatment equipment. There are many existing waste gas treatment equipments, such as the treatment equipment for treating waste gas with complex components recorded in Patent CN107583387A. By setting the exhaust pipe and the waste gas treatment equipment, the leakage of the inhalable reagent can be effectively prevented, and the experimenters can be avoided from being poisoned.

[0043] An animal breeding box 2 is provided inside the bottom box 11. The animal breeding box 2 includes a first box body 21, a second box body 22, a handle 23, and a locking switch 24. The first box body 21 and the second box body 22 are spliced into the structure of a box, such as spliced into Figure 2 the structure of a rectangular box shown. The first box body 21 includes side plates 211, a top plate 212, a bottom plate, a front plate 213 and a rear plate. The side plates 211, the top plate 212, the bottom plate, the front plate 213 and the rear plate are spliced into a rectangular structure with an opening on the left side. The side plates 211, the top plate 212 and the bottom plate are all rigid mesh structure plates, and the side plates 211, the top plate 212 and the bottom plate can also be made of transparent materials. The top plate 212 is rotatably connected to the top of the side plates 211, such as hinged or connected by a hinge; the bottom plate is rotatably connected to the bottom of the side plates 211, such as hinged or connected by a hinge. The front plate 213 and the rear plate are both made of elastic materials, and the front plate 213 and the rear plate can also be mesh structure plates, and the front plate 213 and the rear plate can also be made of transparent elastic materials. The front plate 213 is located on the front side of the first box body 21, and the rear plate is located on the rear side of the first box body 21. The edges of the front plate 213 are respectively connected to the edges of the adjacent side plates 211, the top plate 212 and the bottom plate, and the edges of the rear plate are respectively connected to the edges of the adjacent side plates 211, the top plate 212 and the bottom plate. When the top plate 212 rotates upward and the bottom plate rotates downward, the front plate 213 and the rear plate undergo adaptive deformation.

[0044] The first box body 21 and the second box body 22 have the same structure and are symmetrically arranged. The second box body 22 includes a side wall plate, a top wall plate, a bottom wall plate, a front wall plate and a rear wall plate. The side wall plate has the same structure and material as the side plate 211, the top wall plate has the same structure and material as the top plate 212, the bottom wall plate has the same structure and material as the bottom plate, the front wall plate has the same structure and material as the front plate 213, and the rear wall plate has the same structure and material as the rear plate. The second box body 22 has an opening on the right side. When the first box body 21 and the second box body 22 are symmetrically arranged, the left opening of the first box body 21 is docked with the right opening of the second box body 22, and both can deform.

[0045] The handle 23 is arranged on the top of the animal breeding box 2. Specifically, see Figure 2 , the handle 23 is an upwardly convex arcuate structure. One side edge of the bottom of the arcuate structure is rotatably connected to the edge of the top plate 211 near the left opening through a hinge or a rotating shaft, and the other side edge of the bottom of the arcuate structure is rotatably connected to the edge of the top wall plate near the right opening through a hinge or a rotating shaft, that is, the first box body 21 and the second box body 22 are symmetrically arranged on both sides of the arcuate structure in the width direction. One function of the handle 23 is for hand carrying, and the other function is to connect the first box body 21 and the second box body 22.

[0046] The locking switch 24 is installed on the handle 23, and the deformation of the first box body 21 and the second box body 22 can be controlled through the locking switch 24. Specifically, the locking switch 24 includes a front magnetic attraction switch 241, a rear magnetic attraction switch and a switch board 242. The front magnetic attraction switch 241 includes two magnetic attraction blocks. Both magnetic attraction blocks are connected between the front plate 213 and the front wall, and the magnetic attraction block is fixedly connected to the corresponding front plate 213 or front wall plate. One magnetic attraction block is located above, and the other magnetic attraction block is located below. The rear magnetic attraction switch has the same structure as the front magnetic attraction switch 241 and is symmetrically arranged. The rear magnetic attraction switch is installed between the rear plate and the rear wall plate. Both the rear magnetic attraction switch and the front magnetic attraction switch 241 are electro-controlled magnetic attraction switch structures of the prior art, and the control buttons of the rear magnetic attraction switch and the control buttons of the front magnetic attraction switch 241 are both installed on the switch board 242. The switch board 242 is installed on the handle 23, and the batteries of the rear magnetic attraction switch and the front magnetic attraction switch 241 can be arranged on the handle 23. The magnetic attraction blocks located above are all connected to the handle 23,

[0047] See Figure 2, when the animal breeding box 2 is placed naturally, it is in a cuboid structure. The front magnetic switch 241 and the rear magnetic switch are closed respectively. Under the action of the front magnetic switch 241, the rear magnetic switch, the supporting force of the side wall plate and the side plate 211, and gravity, the animal breeding box 2 is in a cuboid structure. Since the front magnetic switch 241 and the rear magnetic switch cannot deform, the locking switch 24 locks the positions of the top surface, the front surface and the rear surface of the animal breeding box 2. Also, since the bottom surface of the animal breeding box 2 is parallel to the inner bottom surface of the outer box body 1, the shape of the bottom surface of the animal breeding box 2 is also locked. Then, the front, rear, top and bottom surfaces of the animal breeding box 2 are all locked in position. Naturally, the left and right surfaces of the animal breeding box 2 are also locked in position.

[0048] See Figure 3 , when the handle 23 is lifted by hand to make the animal breeding box 2 suspended, and the control button of the rear magnetic switch and the control button of the front magnetic switch 241 are pressed, the two magnetic blocks of the rear magnetic switch are separated, and the two magnetic blocks of the front magnetic switch 241 are separated. Then, under the action of gravity, the bottom plate and the bottom wall plate both rotate downward, and under the action of the hand-lifting force, the top plate 212 and the top wall plate both rotate upward. Then, the distance between the side plate 211 and the side wall plate is shortened, that is, the width of the animal breeding box 2 becomes shorter. Then, the animal located inside the animal breeding box 2 is clamped by the side plate 211 and the side wall plate, so the animal is fixed. At this time, if an elastic sleeve is used to cover the outside of the animal breeding box 2, the fixing effect of the animal is better. Note that the elastic stretching limit of the front plate 213, the rear plate, the front wall plate and the rear wall plate should be selected so that the separation distance between the two magnetic blocks cannot escape the animal. The fixed animal can be used for experimental operations such as drug gavage and injection.

[0049] If the animal needs to be released to move freely again, the animal breeding box 2 is placed in the outer box body 1 or on the experimental table for subsequent experiments. The handle 23 and all control buttons are released. Then, under the action of gravity and magnetic attraction, the front magnetic switch 241 and the rear magnetic switch are closed, and the animal breeding box 2 returns to the previous cuboid structure.

[0050] Under the inventive concept of this embodiment, the animal breeding box 2 is used to breed animals, and the animals can move inside the animal breeding box 2. The research and development equipment we designed can meet the needs of both the free movement of animals and the fixation of animals, and can also meet the construction of animal models with lung injury. It has multiple functions and is convenient to operate.

[0051] Preferably, a feeding trough is provided inside the animal breeding box 2. For example, a feeding trough is provided inside the first box body 21 or the second box body 22. The food and water required for the survival of the animals are placed in the feeding trough. Preferably, the feeding trough is arranged at the bottom end position of the inner side wall of the side plate 211 or on the front wall plate, which does not interfere with the deformation of the front plate 213 and the rear plate and is also convenient for the animals to eat the food in the feeding trough.

[0052] See Figure 1 At the air injection hole, an air injection pipe 3 is connected. The edge of the air injection hole is connected to the edge of the air injection pipe 3, and a sealant is applied at the connection to prevent air leakage. One end of the air injection pipe 3 connected to the air injection hole is used to inject the inhalable reagent into the outer box 1, and the other end of the air injection pipe 3 is used to connect to the inhalable reagent source, such as connecting the air injection pipe 3 to a gas tank containing poisonous gas. Preferably, the air injection pipe 3 is a flexible and bendable pipe. After the air injection pipe 3 is provided, the length of the air injection pipe 3 can be determined according to the requirements of the indoor layout design, so that the inhalable reagent source can be placed farther away from the outer box 1, avoiding the risk of a sudden sharp increase in the concentration of poisonous gas in the indoor environment caused by the simultaneous leakage of the outer box 1 and the inhalable reagent source.

[0053] Example 2

[0054] A research and development device for a drug for treating lung injuries is basically the same in structure as that of Example 1, except that:

[0055] See Figures 4-7 As shown in the figure, the handle 23 has a hollow structure. The locking switch 24 includes a front switch, a rear switch, and a connecting strip 246. The front switch includes an upper pipe 243, a connecting plate 244, a lower pipe 245, and a pressing plate 247. Both ends of the upper pipe 243 are in an open state. The upper pipe 243 is fixedly connected between the front plate 213 and the front wall plate. The lower pipe 245 is also fixedly connected between the front plate 213 and the front wall plate. The upper pipe 243 is located above the lower pipe 245, and the lower pipe 245 is sleeved inside the lower end of the upper pipe 243, and the lower pipe 245 can move up and down along the upper pipe 243. The connecting plate 244 is fixedly arranged inside the upper pipe 243 and is located above the lower pipe 245. A through hole is provided on the connecting plate 244. The front switch and the rear switch have the same structure. The front switch is located in front of the animal breeding box 2, and the rear switch is located behind the animal breeding box 2, and they are symmetrically arranged on both sides of the handle 23 along the length direction. The tops of the upper pipes 243 of the front switch and the rear switch are both connected to the handle 23. The connecting strip 246 is arranged inside the handle 23. The end of the connecting strip 246 can penetrate through the through hole of the upper pipe 243 and the connecting plate 244 on the same side as it, and is finally fixedly connected to the top of the lower pipe 245 on the same side as it. The connecting strip 246 is an elastic strip, which has both rigidity and bending ability, such as being prepared from a shape memory alloy or a bendable and resetable steel bar. An opening is provided at the top of the handle 23. The pressing plate 247 is inserted into the opening from the outside of the handle 23 and is fixedly connected to the connecting strip 246. The top of the pressing plate 247 is located outside the handle 23.

[0056] When there is no external force, the animal breeding box 2 is placed inside the outer box body 1 or on the tabletop. The lower pipe 245 abuts against the connecting plate 244, the connecting strip 246 bends naturally, and a part of the pressing plate 247 is located outside the handle 23. Refer to Figures 4-5. When lifting the handle 23 to suspend the animal breeding box 2 and pressing down the pressing plate 247, the connecting strip 246 is squeezed downward. The end of the connecting strip 246 moves downward along the inner wall of the upper pipe 243 on its same side, pushing open the lower pipe 245. And due to the action of gravity, the lower pipe 245 is separated from the connecting strip 246, and the lower pipe 245 drops downward. The lower bottom plate and the bottom wall plate both rotate downward. Under the action of the lifting force by hand, the top plate 212 and the top wall plate both rotate upward. Then the distance between the side plate 211 and the side wall plate is shortened, that is, the width of the animal breeding box 2 becomes shorter and becomes Figures 6-7 the structure shown. In order to make the rotation angles of the lower bottom plate, the bottom wall plate, the top plate 212 and the top wall plate a little larger, a connecting rope 248 is arranged between the connecting strip 246 and the lower pipe 245. Note the selection of the length of the connecting rope 248 so that the lower pipe 245 does not slide outside the upper pipe 243.

[0057] The locking switch 24 of this embodiment does not require electricity, is a pure mechanical structure, is environmentally friendly and energy-saving, and is also convenient to operate.

[0058] Preferably, magnetic components that attract each other are provided at the top of the lower pipe 245 and the bottom of the connecting plate 244. Under the magnetic force of the magnetic components, the top of the lower pipe 245 is attracted to the bottom of the connecting plate 244. For example, the lower pipe 245 is set as an iron pipe, and the connecting plate 244 is set as a magnetic plate that can attract the iron pipe. When there is magnetism, when the animal breeding box 2 is placed statically inside the outer box body 1, the stability is better. When lifting the handle 23 to suspend the animal breeding box 2 and pressing down the pressing plate 247, the connecting strip 246 is squeezed downward. The end of the connecting strip 246 moves downward along the inner wall of the upper pipe 243 on its same side, pushing open the lower pipe 245 and forcing the lower pipe 245 to be separated from the connecting strip 246.

[0059] Embodiment 3

[0060] A research and development device for a drug for treating lung injuries is basically the same in structure as that of Embodiment 1, except that:

[0061] The bottom surface and the side surfaces of the animal breeding box 2 (i.e., the bottom plate of the first box body 21, the side plate 211, the bottom wall plate of the second box body 22, and the side wall plate) are set as a closed structure. For example, the position below 1 / 4 of the height of the side wall of the animal breeding box 2 is set as a closed structure. The bottom plate of the first box body 21 and the bottom wall plate of the second box body 22 are connected by a waterproof elastic cloth. Then, excrements such as urine and feces of the animal can be received by the bottom of the animal breeding box 2. And even if the bottom of the animal breeding box 2 undergoes a deformation with a reduced width, the excrements are located at the position of the bottom corner of the animal breeding box 2. Since the width of the bottom corner is smaller than the body width of the animal, then, as the width of the animal breeding box 2 shrinks, when the animal is fixed in the animal breeding box 2, the animal excrements can still be separated from the animal, and the excrements can be taken away from the position below the animal, reducing the probability of the animal excrements soiling the animal's body.

[0062] In addition, a sampling port can be opened on the bottom of the animal breeding box 2 (such as the bottom plate of the first box body 21 or the bottom wall plate of the second box body 22), and an openable closed cover is installed at the sampling port. For example, the closed cover is buckled at the sampling port. Then, when taking out the animal excrements, open the closed cover and take them from the sampling port, and cover the closed cover at the sampling port after taking. Note the size design of the sampling port to prevent the experimental animals from falling from here, and instruments such as forceps for taking excrements can enter the sampling port.

[0063] Embodiment 4

[0064] A research and development device for a drug for treating lung injury is basically the same in structure as that in Embodiment 1. For the differences, refer to Figure 8 : The inside of the bottom box 11 is separated into multiple test areas by a partition 4, and a plurality of ventilation holes are opened on the partition 4. Then, one animal breeding box 2 can be placed in each test area, and multiple animal tests can be carried out simultaneously, with high efficiency. Even if the violent reaction of the animal shakes the animal breeding box 2, there is still the partition 4 to block it.

[0065] It should be noted that the connection relationships of the components not specifically mentioned in the present invention are default to adopt the existing technologies. Since they do not involve the inventive points and are widely applied in the existing technologies, the structural connection relationships are not described in detail.

[0066] It should be noted that when the present invention involves numerical ranges, it should be understood that both endpoints of each numerical range and any value between the two endpoints can be selected. Since the adopted step methods are the same as those in the embodiments, in order to prevent repetition, the present invention describes the preferred embodiments. Although the preferred embodiments of the present invention have been described, those skilled in the art can make additional changes and modifications to these embodiments once they know the basic creative concepts. Therefore, the appended claims are intended to be construed as including the preferred embodiments and all changes and modifications falling within the scope of the present invention.

[0067] Obviously, those skilled in the art can make various modifications and variations to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalent technologies, the present invention is also intended to include these modifications and variations.

Claims

1. R & D equipment for a drug for treating lung injuries, characterized in that, it includes an outer box body (1), the outer box body (1) includes a bottom box (11) and a box cover (12), and an air injection hole and an exhaust hole are provided on the outer box body (1); an animal breeding box (2) is arranged inside the bottom box (11), the animal breeding box (2) includes a first box body (21) and a second box body (22), the first box body (21) includes a three-dimensional structure with one side open formed by splicing side plates (211), a top plate (212), a bottom plate, a front plate (213) and a rear plate, the side plates (211), the top plate (212) and the bottom plate are all mesh structure plates, the top plate (212) and the bottom plate are respectively rotatably connected to both ends of the side plates (211), the front plate (213) and the rear plate are both made of elastic materials, and the first box body (21) has the same structure as the second box body (22) and is arranged oppositely; the first box body (21) and the second box body (22) are rotatably connected to both ends of a handle (23), a locking switch (24) is installed on the handle (23), and the deformation of the first box body (21) and the second box body (22) is controlled by the locking switch (24); the locking switch (24) includes a front magnetic attraction switch (241) and a rear magnetic attraction switch, the front magnetic attraction switch (241) and the rear magnetic attraction switch are both installed between the first box body (21) and the second box body (22), the front magnetic attraction switch (241) and the rear magnetic attraction switch can both be separated up and down, the control buttons of the rear magnetic attraction switch and the control button of the front magnetic attraction switch (241) are both installed on the handle (23); the control buttons of the rear magnetic attraction switch and the control button of the front magnetic attraction switch (241) are both installed on a switch board (242), and the switch board (242) is installed on the handle (23); Alternatively, the handle (23) has a hollow structure, and the locking switch (24) includes a front switch, a rear switch, and a connecting strip (246); the front switch includes an upper tube (243), a lower tube (245), and a pressing plate (247). Both the upper tube (243) and the lower tube (245) are arranged between the front plate (213) of the first box body (21) and the front wall plate of the second box body (22). The lower tube (245) is sleeved inside the lower end of the upper tube (243) in an up-and-down movable manner. A connecting plate (244) is arranged above the lower tube (245) inside the upper tube (243), and a through hole is formed in the connecting plate (244). The front switch and the rear switch have the same structure and are symmetrically arranged on both sides of the handle (23) along the length direction. The upper tubes (243) of the front switch and the rear switch are both connected to the handle (23). The connecting strip (246) is arranged inside the handle (23). The end of the connecting strip (246) can penetrate through the through hole of the upper tube (243) and the connecting plate (244) on the same side as it, and is finally fixedly connected to the top of the lower tube (245) on the same side as it. The pressing plate (247) movably penetrates through the top of the handle (23).

2. The R & D equipment for a drug for treating lung injury according to claim 1, characterized in that, the connecting strip (246) is an elastic strip.

3. The R & D equipment for a drug for treating lung injury according to claim 1, characterized in that, a connecting rope (248) is arranged between the connecting strip (246) and the lower tube (245).

4. The R & D equipment for a drug for treating lung injury according to claim 1, characterized in that, magnetic components that attract each other are arranged between the lower tube (245) and the connecting plate (244).

5. The R & D equipment for a drug for treating lung injury according to claim 1, characterized in that, a feeding trough is arranged inside the animal breeding box (2).

6. The R & D equipment for a drug for treating lung injury according to claim 1, characterized in that, the bottom surface and the lower end of the side surface of the animal breeding box (2) are set as closed structures.

7. The R & D equipment for a drug for treating lung injury according to claim 1, characterized in that, the inside of the bottom box (11) is divided into multiple test areas by a partition board (4), and a plurality of ventilation holes are formed in the partition board (4).

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