A method for measuring the activity concentration of Sr in a SrCl2 solution 89 A method for measuring the activity concentration of Sr in a SrCl2 solution 90 A method for measuring the activity concentration of Sr in a SrCl2 solution

Abstract

This invention discloses a 89 SrCl2 solution 90 Mass spectrometry methods for measuring Sr activity concentration include: obtaining the concentration calculated during mass spectrometry measurement. 90 The formula required for the molar concentration of Sr is to use D in equation (12). F90 D E D was obtained by mass spectrometry; the analyte was calculated using equation (12). 89 SrCl2 solution 90 The molar concentration of Sr is then calculated. 90 The mass concentration of Sr; according to 90 Calculation of Sr mass concentration 90 The activity concentration of Sr; this invention eliminates the need for strontium and yttrium separation, simplifying the operation process, reducing personnel radiation exposure, and allowing direct calculation based on measurement data. 90 Sr activity concentration eliminates the intermediate strontium and yttrium activity concentration conversion process, avoiding 90 The impact of Y recovery rate on the final measurement results.

Description

Technical Field

[0001] The present invention relates to the field of radiochemistry, and particularly relates to a 90 method for measuring the mass spectrometry of the 90 Sr activity concentration in SrCl2 solution. Background Technique

[0002] 89 Sr is a radioactive nuclide with a physical half-life of 50.53 d. When it decays, it mainly emits β-rays and is an ideal therapeutic nuclide. Strontium chloride 89 Sr] solution can be used as a therapeutic agent for metastatic cancerous bone pain. With a single administration, it has a long analgesic time and mild side effects. It is mainly used for relieving bone pain caused by secondary bone metastasis of advanced malignant tumors such as prostate cancer and breast cancer. It is a radioactive drug with the best curative effect and the lowest toxicity for treating bone metastasis of prostate and breast cancer and has good market application prospects.

[0003] Strontium chloride 89 Sr] can be prepared by irradiating strontium carbonate with Sr abundance above 99% in a reactor. After 88 Sr(n,γ) 88 Sr reaction to generate 89 Sr, and then obtaining high-purity strontium chloride 89 Sr] solution after a series of separations. 89 Sr has a neutron absorption cross-section of 0.42 b, and a small amount of 90 Sr may be generated during the preparation process. Its half-life is 28.6 a, and the β-ray energy of its daughter 90 Y is 2.284 MeV, which is a highly toxic substance and will significantly affect the product quality. Referring to the domestic and international industry requirements, the ratio of the radioactive activity of 89 Sr to the 90 Sr activity in the strontium chloride 89 Sr solution should be less than 2×10 -4 %, that is, the activity concentration ratio is less than 2×10 -4 %, and the product is qualified. Therefore, the determination of the activity concentration of 89 Sr in the strontium chloride 90 Sr product is of great significance for the quality control of the strontium chloride 89 Sr solution product.

[0004] 90 89 Currently, 90 the measurement of the 89 Sr activity concentration generally uses the principle of radioactive equilibrium. After 90 Sr and 90 Y reach radioactive equilibrium in the 90 Sr solution, 90 Y is separated and recovered, and by measuring 90Y is indirectly determined 90 The activity concentration of Sr. This method requires... 90 The separation of Y (ion exchange method, HDEHP extraction chromatography, fuming nitric acid method) is cumbersome, time-consuming, and exposes personnel to high levels of radiation. 89 Sr solution 90 The amount of Y is extremely low, and its recovery rate will seriously affect the final measurement results.

[0005] Mass spectrometry is a method that uses electric and magnetic fields to separate moving ions according to their mass-to-charge ratio for detection. It has advantages such as high sensitivity, low detection limit, fast analysis speed, and the ability to simultaneously measure multiple isotopes. In recent years, with the development of mass spectrometry and the application of mass spectrometers, mass spectrometry has begun to be used for strontium isotope measurement. However, mass spectrometry has not yet been directly applied to medical strontium chloride. 89 Sr] solution 90 Report on the measurement of Sr activity concentration. Summary of the Invention

[0006] The technical problem to be solved by this invention is the existing... 89 SrCl2 solution 90 The method for detecting Sr activity concentration needs to be carried out. 90 The separation of Y (ion exchange method, HDEHP extraction chromatography, fuming nitric acid method) is cumbersome, time-consuming, and exposes personnel to high levels of radiation. 89 Sr solution 90 The content of Y is extremely low, and its recovery rate will seriously affect the final measurement results.

[0007] This invention provides 89 SrCl2 solution 90 Mass spectrometry methods for measuring Sr activity concentration include:

[0008] Calculation in mass spectrometry measurement 90 The formula for determining the molar concentration of Sr is shown in equation (12).

[0009]

[0010] In the formula, c1 is 89 SrCl2 solution 90 The molar concentration of Sr, in mol / L; a1 is 90 The specific activity of Sr is 5.1103 × 10⁻⁶. 12 Bq / g; a2 is 90 The specific activity of Y is 2.0151 × 10⁻⁶. 16 Bq / g; M1 is 90 The relative atomic mass of Sr is 89.9077; M2 is... 90The relative atomic mass of Y is 89.9071; D F90 express 89 The count rate of SrCl2 solution with a mass number of 90, in cps; c is the concentration of Strontium standard solution B and Yttrium standard solution E, in mol / L; D B D represents the total count rate in strontium standard solution B, in cps. E The total count rate in yttrium standard solution E is expressed in cps.

[0011] In equation (12), D F90 D E D was obtained by mass spectrometry.

[0012] The test is calculated using equation (12). 89 SrCl2 solution 90 The molar concentration of Sr is then calculated. 90 Mass concentration of Sr;

[0013] according to 90 Calculation of Sr mass concentration 90 Sr activity concentration.

[0014] As one possible design, to obtain calculations in mass spectrometry measurements 90 The specific steps for formulating the molar concentration of Sr are as follows:

[0015] Get 90 Sr and 90 The relationship between the radioactivity of Y and its radioactivity is shown in Equation 6.

[0016] a1M1c1=a2M2c2 (6)

[0017] In the formula, a1 is 90 The specific activity of Sr is 5.1103 × 10⁻⁶. 12 Bq / g; a2 is 90 The specific activity of Y is 2.0151 × 10⁻⁶. 16 Bq / g; m1 is the concentration of Bq / g in the sample. 90 The mass of Sr is expressed in grams; m² represents the amount of Sr in the sample. 90 The mass of Y, in grams; n1 is the mass of the sample. 90 The amount of substance of Sr is expressed in mol; n2 is the amount of substance of Sr in the sample. 90 The amount of substance Y, in mol; c1 is the amount of substance Y in the sample. 90 The concentration of Sr is expressed in mol / L; c2 represents the concentration of Sr in the sample. 90 The molar concentration of Y is expressed in mol / L; M1 is... 90 The relative atomic mass of Sr is 89.9077; M2 is...90 The relative atomic mass of Y is 89.9071.

[0018] Obtain the count rate with a mass number of 90 and calculate it separately. 90 Sr and 90 The count rate of Y;

[0019] A count rate of 90 with a mass number was obtained using a mass spectrometer.

[0020]

[0021] This represents the count rate of a sample with a mass number of 90, expressed in cps. Indicating the sample 90 The count rate of Y, in cps; Indicating the sample 90 Sr count rate, measured in cps;

[0022] Calculate separately 90 Sr and 90 The count rate of Y

[0023]

[0024]

[0025] In equations (10) and (11), Indicating the sample 90 Sr count rate, measured in cps; D B c1 represents the total count rate in strontium standard solution B, in cps; c2 represents the total count rate in the sample. 90 The concentration of Sr is expressed in mol / L. Indicating the sample 90 The count rate of Y, measured in cps; D E c1 represents the total count rate in yttrium standard solution E, in cps; c2 represents the total count rate in the sample. 90 The concentration of Y is expressed in mol / L.

[0026] Equation (12) is obtained from equations (6), (9), (10) and (11).

[0027] As one possible design, the D B The calculation formula is as follows:

[0028]

[0029] In the formula, The count rates of each isotope in strontium standard solution B are represented by i, which are 84, 85, 86, 87, and 88, respectively.

[0030]

[0031] In the formula, This represents the count rate of each isotope in the yttrium standard solution E, where m equals 89.

[0032] As one possible design, 90 Calculation of Sr mass concentration 90 The formula for calculating the activity concentration of Sr is as follows:

[0033]

[0034] In the formula, A′1 is the Sr-90 activity concentration in the sample, in Bq / L; M1 is the atomic weight of Sr-90, specifically 89.9077; N A Here is Avogadro's constant, specifically 6.02 × 10⁻⁶. 23 λ is the Sr-90 decay constant, specifically 7.6294 × 10⁻⁶. -10 s -1 .

[0035] As one possible design, the The data were obtained by inductively coupled plasma mass spectrometry in detector digital-analog signal adaptive mode.

[0036] As one possible design, the The data were obtained by inductively coupled plasma mass spectrometry in detector digital-analog signal adaptive mode.

[0037] As one possible design, the diluent in both the strontium standard solution B and the yttrium standard solution E is a 1‰ to 5% UP-S grade nitric acid solution.

[0038] As a possible design, inductively coupled plasma mass spectrometry (ICP-MS) requires mass calibration and detector cross-calibration before sample introduction.

[0039] As one possible design, 89 The SrCl2 solution must meet the following requirements during detection. 90 Sr and 90 Y is in a long-term equilibrium state.

[0040] As one possible design, when using the mass spectrometer, the strontium sensitivity at low resolution is greater than 2 × 10⁻⁶. 5 cps / (μg / L).

[0041] The beneficial effects of this invention are as follows:

[0042] 1. Strontium chloride was obtained by mass spectrometry. 89 Sr] solution 90The mass concentration of Sr was obtained through calculation. 90 The activity concentration of Sr. Compared to traditional methods that measure... 90 Y activity is indirectly obtained 90 Sr-related data have advantages such as high sensitivity, low detection limit, and fast analysis speed, enabling direct, rapid, and accurate determination. 89 SrCl2 solution 90 The mass concentration of Sr is thus obtained. 89 SrCl2 solution 90 The activity concentration of Sr eliminates the intermediate strontium and yttrium activity concentration conversion process, avoiding 90 The impact of Y recovery rate on the final measurement results, for strontium chloride [ 89 The commercialization of Sr] solution preparation is of great significance.

[0043] 2. Existing 90 Methods for measuring Sr activity concentration require the separation of Sr and yttrium in liquid samples, which is complex, prone to radioactive contamination, time-consuming, labor-intensive, and exposes personnel to high radiation doses. In contrast to existing methods, this invention allows for the direct measurement of Sr chloride using mass spectrometry. 89 Sr] solution 90 The Sr mass concentration was obtained through calculation. 90 Sr activity concentration. This method eliminates the need for strontium and yttrium separation, simplifying the operation and reducing personnel radiation exposure, while also achieving... 90 Rapid determination of Sr activity concentration is highly efficient and has broad application prospects. Detailed Implementation

[0044] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the embodiments. The illustrative embodiments and descriptions of this invention are only for explaining this invention and are not intended to limit this invention.

[0045] For existing measurement 89 SrCl2 solution 90 The method for determining Sr activity concentration requires... 90 The separation of Y (ion exchange method, HDEHP extraction chromatography, fuming nitric acid method) is cumbersome, time-consuming, and exposes personnel to high levels of radiation. 90 The recovery rate of Y can significantly affect the final measurement results. This invention provides a method for measuring Y using a mass spectrometer. 89 SrCl2 solution 90 Sr mass concentration, then according to 90 The Sr mass concentration is calculated to obtain 90 Sr activity concentration.

[0046] In view of the above problems, the present invention discloses a89 SrCl2 solution 90 The mass spectrometry method for measuring Sr activity concentration includes the following steps:

[0047] S1. Measurement of standard solutions;

[0048] S2. Sample measurement;

[0049] S3. Data processing.

[0050] Step S1 specifically includes:

[0051] S11. Using strontium natural concentration standards and yttrium natural concentration standards with valid standard substance certificates, and with 1‰ to 5% UP-S grade nitric acid solution as diluent, prepare strontium standard solution B and yttrium standard solution E with concentrations of c, respectively. The unit of c is mol / L.

[0052] S12. Inductively Coupled Plasma Mass Spectrometer Parameter Adjustment:

[0053] 1) Preheating: The mass spectrometer should be preheated for at least 72 hours before startup.

[0054] 2) Tuning and calibration: After the mass spectrometer is ignited, the tuning liquid is introduced, and the torch coordinates, sample gas flow rate, auxiliary gas flow rate, peristaltic pump speed, etc. are adjusted to perform mass calibration of the instrument and cross-calibration of the detector, so that the sensitivity index of the instrument meets the measurement requirements.

[0055] S13: Measurement: Strontium standard solution B and yttrium standard solution E were measured using inductively coupled plasma mass spectrometry. The specific steps are as follows:

[0056] 1): In the detector's digital-to-analog signal adaptive mode, all strontium isotopes in strontium standard solution B (i.e., 84 Sr、 86 Sr、 87 Sr、 88 The count rate of Sr), i.e., the count rate when the monitored quality numbers are 84, 86, 87, and 88, is obtained respectively. i equals 84, 86, 87, and 88 respectively.

[0057] 2): In the detector's digital-to-analog signal adaptive mode, all yttrium isotopes in the yttrium standard solution E (i.e., 89 The count rate of Y), i.e., the count rate when the monitored quality number is 89, is obtained. m equals 89.

[0058] Step S2 specifically includes:

[0059] S21: Strontium chloride [ 89 Sr] in the sample solution 90Sr and 90 Y Long-term equilibrium: According to the principle of long-term radioactive equilibrium, when the half-life T1 of the parent A is very long, and the half-life T1 of the parent A is much longer than the half-life T2 of the daughter A, that is, T1>>T2, λ1<<λ2, since λ1<<λ2, when the time is long enough [t>>(7~10)T2], the parent A and the daughter A can reach long-term radioactive equilibrium, at which time the radioactivity of the parent A and the daughter A is equal. 90 The half-life of Sr is 27.2 hours. 90 The half-life of Y is 64 hours, which conforms to T1>>T2. Therefore, strontium chloride [ 89 The Sr] solution sample was left to stand for a sufficient time to allow it to reach its optimal concentration. 90 Sr and 90 The long-term equilibrium of Y.

[0060] S22: Sample Measurement: Using inductively coupled plasma mass spectrometry, under conditions consistent with those for the standard solution measurement, the sample F (strontium chloride) was measured. 89 Isotope count rate with a mass number of 90 in [Sr] solution The unit is cps.

[0061] Step S3 specifically includes:

[0062] S31. Sample F 90 Sr and 90 Y reaches long-run equilibrium, therefore:

[0063] A1=A2(1)

[0064] In the formula, A1 is 90 The radioactivity of Sr, measured in Bq; A2 is... 90 The radioactivity of Y, expressed in Bq.

[0065] at the same time,

[0066] A1=a1m1(2)

[0067] A2=a2m2(3)

[0068] m1=M1n1=M1c1V(4)

[0069] m2=M2n2=M1c2V(5)

[0070] Therefore, according to equations (2), (3), (4), and (5), the following can be calculated:

[0071] a1M1c1=a2M2c2(6)

[0072] In the formula, a1 is 90 The specific activity of Sr is 5.1103 × 10⁻⁶.12 Bq / g; a2 is 90 The specific activity of Y is 2.0151 × 10⁻⁶. 16 Bq / g; m1 is the concentration of Bq / g in the sample. 90 The mass of Sr is expressed in grams; m² represents the amount of Sr in the sample. 90 The mass of Y, in grams; n1 is the mass of the sample. 90 The amount of substance of Sr is expressed in mol; n2 is the amount of substance of Sr in the sample. 90 The amount of substance Y, in mol; c1 is the amount of substance Y in the sample. 90 The concentration of Sr is expressed in mol / L; c2 represents the concentration of Sr in the sample. 90 The molar concentration of Y is expressed in mol / L; M1 is... 90 The relative atomic mass of Sr is 89.9077; M2 is... 90 The relative atomic mass of Y is 89.9071.

[0073] S32. Calculate the total count rate in strontium standard solution B:

[0074]

[0075] In the formula, The count rates of each isotope in strontium standard solution B are represented by i, which are 84, 85, 86, 87, and 88, respectively.

[0076] S33. Calculate the total count rate in yttrium standard solution E:

[0077]

[0078] In the formula, This represents the count rate of each isotope in the yttrium standard solution E, where m equals 89.

[0079] S34. Calculate the sample content 90 Mass concentration of Sr:

[0080] Strontium chloride 89 The isotope with a mass number of 90 in the Sr solution sample F contains 90 Sr and 90 Y, therefore, the count rate with a measured mass number of 90 is 90 Sr and 90 The sum of the count rates of Y, i.e.:

[0081]

[0082] In the formula, This represents the count rate of sample F with a mass number of 90, expressed in cps. Indicating that in sample F 90The count rate of Y, in cps; Indicating that in sample F 90 The count rate of Sr, measured in cps.

[0083] Because all isotopes of the same element have identical chemical properties and exhibit consistent responses to drying, evaporation, atomization, and ionization in high-temperature plasma—that is, consistent ionization efficiency—therefore:

[0084]

[0085]

[0086] In the formula, Indicating that in sample F 90 Sr count rate, measured in cps; D B c1 represents the total count rate in strontium standard solution B, in cps; c2 represents the total count rate in the sample. 90 The concentration of Sr is expressed in mol / L. Indicating that in sample F 90 The count rate of Y, measured in cps; D E c1 represents the total count rate in yttrium standard solution E, in cps; c2 represents the total count rate in the sample. 90 The concentration of Y is expressed in mol / L.

[0087] According to equations (6), (9), (10), and (11), we know that:

[0088]

[0089] In the formula, c1 represents the concentration of sample F. 90 The molar concentration of Sr, in mol / L; a1 is 90 The specific activity of Sr is 5.1103 × 10⁻⁶. 12 Bq / g; a2 is 90 The specific activity of Y is 2.0151 × 10⁻⁶. 16 Bq / g; M1 is 90 The relative atomic mass of Sr is 89.9077; M2 is... 90 The relative atomic mass of Y is 89.9071. The count rate of sample F with a mass number of 90 is expressed in cps; c represents the concentration of strontium standard solution B and yttrium standard solution E, expressed in mol / L; D B D represents the total count rate in strontium standard solution B, in cps. E The total count rate in yttrium standard solution E is expressed in cps.

[0090] therefore:

[0091] c′1=c1M1 (12)

[0092] In the formula, c1 represents the concentration of sample F. 90 The molar concentration of Sr, in mol / L; c′1 is the concentration of Sr in sample F. 90 The mass concentration of Sr, in g / L; M1 is 90 The relative atomic mass of Sr is 89.9077.

[0093] S35. Calculate the sample content 90 Sr activity concentration:

[0094]

[0095] In the formula, A′1 is the Sr-90 activity concentration in the sample, in Bq / L; M1 is the atomic weight of Sr-90, specifically 89.9077; N A Here is Avogadro's constant, specifically 6.02 × 10⁻⁶. 23 λ is the Sr-90 decay constant, specifically 7.6294 × 10⁻⁶. -10 s -1 .

[0096] For example

[0097] Step 1: Measurement of standard solution

[0098] S11. Preparation of Standard Solutions: Standard solutions were prepared using natural strontium concentration standards (Sr concentration of 1000 mg / L) and natural yttrium concentration standards (Y Sr concentration of 1000 mg / L) with valid standard substance certificates. 1 mol / L strontium standard solution B and 1 mol / L yttrium standard solution E were prepared using 1‰–5% UP-S grade nitric acid solution as diluent.

[0099] S12. Inductively Coupled Plasma Mass Spectrometer Parameter Adjustment:

[0100] 1) Preheating: The mass spectrometer should be preheated for at least 72 hours before startup.

[0101] 2) Tuning and Calibration: After ignition, the mass spectrometer is filled with tuning fluid. The torch coordinates, sample gas flow rate, auxiliary gas flow rate, and peristaltic pump speed are adjusted to perform mass calibration and detector cross-calibration, ensuring that the instrument's sensitivity, oxide content, and other parameters meet the measurement requirements. In detector counting mode, peak shape and height are scanned in real time to ensure symmetrical peaks with a flat center, achieving a strontium sensitivity of 2 × 10⁻⁶ at low resolution. 5 cps / (μg / L) or higher.

[0102] S13: Standard Measurement: Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used to measure 1 mol / L strontium and yttrium standard solutions. The specific steps are as follows:

[0103] 1) Measure all strontium isotopes in strontium standard solution B ( 84 Sr、 86 Sr、 87 Sr、 88 The count rate of Sr), i.e., the count rate when the monitored quality numbers are 84, 86, 87, and 88, is obtained respectively. i equals 84, 86, 87, and 88 respectively. Where,

[0104] 2) Measure all yttrium isotopes in yttrium standard solution E ( 89 The count rate of Y), i.e., the count rate when the monitored quality number is 89, is obtained.

[0105] Step 2 includes the following steps:

[0106] S21: Strontium chloride [ 89 Sr] in the sample solution 90 Sr and 90 Y long-term equilibrium: Strontium chloride [ 89 The Sr] solution sample F has been stored for six months. 90 Sr and 90 Y reaches long-term equilibrium.

[0107] S22: Sample Measurement: Using inductively coupled plasma mass spectrometry, under conditions consistent with those for the standard solution measurement, the sample F (strontium chloride) was measured. 89 Isotope count rate with a mass number of 90 in [Sr] solution

[0108] Step 3 includes the following steps:

[0109] 1) In sample F 90 Sr and 90 Y reaches long-run equilibrium, therefore:

[0110] a1M1c1=a2M2c2 (14)

[0111] Right now:

[0112] c2 = 2.5360 × 10 -4 c1 (15)

[0113] In the formula, a1 is 90 The specific activity of Sr is 5.1103 × 10⁻⁶. 12 Bq / g; a2 is90 The specific activity of Y is 2.0151 × 10⁻⁶. 16 Bq / g; c1 is the concentration of Bq / g in the sample. 90 The molar concentration of Sr is expressed in mol / L; c2 is the concentration of Sr in the sample. 90 The molar concentration of Y is expressed in mol / L; M1 is... 90 The relative atomic mass of Sr is 89.9077; M2 is... 90 The relative atomic mass of Y is 89.9071.

[0114] 2) Calculate the total count rate in strontium standard solution B:

[0115]

[0116] In the formula, Let i represent the count rates of each isotope in strontium standard solution B, where i is equal to 84, 86, 87, and 88, respectively.

[0117] 3) Calculate the total count rate in yttrium standard solution E:

[0118]

[0119] 4) Calculate the sample content 90 Mass concentration of Sr:

[0120] Sample F (strontium chloride) 89 The isotope with a mass number of 90 in [Sr] solution contains 90 Sr and 90 Y, therefore, the count rate with a measured mass number of 90 is 90 Sr and 90 The sum of the count rates of Y, i.e.:

[0121]

[0122] In the formula, This represents the count rate of sample F with a mass number of 90, expressed in cps. Indicating that in sample F 90 The count rate of Y, in cps; Indicating that in sample F 90 The count rate of Sr, measured in cps.

[0123] Because all isotopes of the same element have identical chemical properties and exhibit consistent responses to drying, evaporation, atomization, and ionization in high-temperature plasma—that is, consistent ionization efficiency—therefore:

[0124]

[0125]

[0126] In the formula, Indicating that in sample F 90 Sr count rate, measured in cps; D B c1 represents the total count rate in strontium standard solution B, in cps; c2 represents the total count rate in the sample. 90 The concentration of Sr is expressed in mol / L. Indicating that in sample F 90 The count rate of Y, measured in cps; D E c1 represents the total count rate in yttrium standard solution E, in cps; c2 represents the total count rate in the sample. 90 The concentration of Y is in mol / L; the concentrations of strontium standard solution B and yttrium standard solution E are 1 mol / L.

[0127] According to equations (15), (16), (17), (18), (19), and (20), we can know that:

[0128]

[0129] therefore:

[0130] c'1=c1M1=6.6922×10 -3 mg / L(22)

[0131] In the formula, c1 represents the concentration of sample F. 90 The molar concentration of Sr, in mol / L; c′1 is the concentration of Sr in sample F. 90 The mass concentration of Sr, in g / L; M1 is 90 The relative atomic mass of Sr is 89.9077.

[0132] 5) Calculate the sample content 90 Sr activity concentration:

[0133]

[0134] In the formula, A′1 is the Sr-90 activity concentration in the sample, in Bq / L; M1 is 90 The atomic weight of Sr is 89.9077; N A Here is Avogadro's constant, specifically 6.02 × 10⁻⁶. 23 λ is 90 The Sr decay constant is specifically 7.6294 × 10⁻⁶. -10 s -1 .

[0135] The present invention discloses a method for... 89 SrCl2 solution 90Mass spectrometry methods for measuring Sr activity concentration have advantages such as high sensitivity, low detection limit, and fast analysis speed, allowing for direct, rapid, and accurate determination. 89 SrCl2 solution 90 The mass concentration of Sr is thus obtained. 89 SrCl2 solution 90 The activity concentration of Sr eliminates the intermediate strontium and yttrium activity concentration conversion process, avoiding 90 The impact of Y recovery rate on the final measurement results, for strontium chloride [ 89 The commercialization of Sr] solution preparation is of great significance.

[0136] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A kind 89 SrCl2 solution 90 The mass spectrometry method for measuring Sr activity concentration is characterized by, The mass spectrometry measurement method includes: Calculation in mass spectrometry measurement 90 The formula for determining the molar concentration of Sr is shown in equation (12). ； In the formula, c 1 for 89 SrCl2 solution 90 The molar concentration of Sr is expressed in mol / L. a 1 for 90 The specific activity of Sr is 5.1103 × 10⁻⁶. 12 Bq / g; a 2 for 90 The specific activity of Y is 2.0151 × 10⁻⁶. 16 Bq / g; M 1 for 90 The relative atomic mass of Sr is 89.9077. M 2 for 90 The relative atomic mass of Y is 89.9071. express 89 The count rate of SrCl2 solution with a mass number of 90, in cps; c is the concentration of Strontium standard solution B and Yttrium standard solution E, in mol / L; The total count rate in Strontium standard solution B is expressed in cps. The total count rate in yttrium standard solution E is expressed in cps. In equation (12), D F90 D E and D B Measured by mass spectrometry; The test is calculated using equation (12). 89 SrCl2 solution 90 The molar concentration of Sr is then calculated. 90 Mass concentration of Sr; according to 90 Calculation of Sr mass concentration 90 Sr activity concentration.

2. The mass spectrometry measurement method according to claim 1, characterized in that, calculate 90 The specific steps for formulating the molar concentration of Sr are as follows: Get 90 Sr and 90 The relationship between the radioactivity of Y and its radioactivity is shown in equation (6). ； The process of obtaining equation (6) is as follows: ； Equation (6) is obtained by calculating based on equations (1), (2), (3), (4), and (5); In the formula, a 1 for 90 The specific activity of Sr is 5.1103 × 10⁻⁶. 12 Bq / g; a 2 for 90 The specific activity of Y is 2.0151 × 10⁻⁶. 16 Bq / g; m 1 For the sample 90 The mass of Sr, expressed in grams; m 2 For the sample 90 The mass of Y, in grams; n 1 For the sample 90 The amount of substance of Sr is expressed in mol. n 2 For the sample 90 The amount of substance Y, in mol; c 1 For the sample 90 The concentration of Sr is expressed in mol / L. c 2 For the sample 90 The molar concentration of Y is expressed in mol / L. M 1 for 90 The relative atomic mass of Sr is 89.9077. M 2 for 90 The relative atomic mass of Y is 89.9071; A1 is... 90 The radioactivity of Sr, measured in Bq; A2 is... 90 The radioactivity of Y, expressed in Bq; V is the volume of the sample. Obtain the count rate with a mass number of 90 and calculate them separately. 90 Sr and 90 The count rate of Y; A count rate of 90 with a mass number was obtained using a mass spectrometer. ； This represents the count rate of a sample with a mass number of 90, expressed in cps. Indicating the sample 90 The count rate of Y, in cps; Indicating the sample 90 Sr count rate, measured in cps; Calculate separately 90 Sr and 90 The count rate of Y ； In equations (10) and (11), represents the sample. 90 Sr count rate, measured in cps; The total count rate in Strontium standard solution B is expressed in cps. c 1 For the sample 90 The concentration of Sr is expressed in mol / L. Indicating the sample 90 The count rate of Y, in cps; The total count rate in yttrium standard solution E is expressed in cps. c 2 For the sample 90 The concentration of Y is in mol / L; c is the concentration of strontium standard solution B and yttrium standard solution E, in mol / L. Equation (12) is obtained from equations (6), (9), (10) and (11).

3. The mass spectrometry measurement method according to claim 2, characterized in that, The The calculation formula is as follows: ； In the formula Let i represent the count rates of each isotope in B, where i is equal to 84, 85, 86, 87, and 88 respectively. ； In the formula, This represents the count rate of each isotope in the yttrium standard solution E, where m equals 89.

4. The mass spectrometry measurement method according to claim 1, characterized in that, 90 Calculation of Sr mass concentration 90 The formula for calculating the activity concentration of Sr is as follows: ； In the formula, The Sr-90 activity concentration in the sample is expressed in Bq / L. M 1 The atomic weight of Sr-90 is 89.9077; N A Here is Avogadro's constant, specifically 6.02 × 10⁻⁶. 23 λ is the Sr-90 decay constant, specifically 7.6294 × 10⁻⁶. -10 s -1 ; For sample F 90 The mass concentration of Sr is expressed in g / L.

5. The mass spectrometry measurement method according to claim 3, characterized in that, The The data were obtained by inductively coupled plasma mass spectrometry in detector digital-analog signal adaptive mode.

6. The mass spectrometry measurement method according to claim 3, characterized in that, The The data were obtained by inductively coupled plasma mass spectrometry in detector digital-analog signal adaptive mode.

7. The mass spectrometry measurement method according to claim 1, characterized in that, The diluent in both the strontium standard solution B and the yttrium standard solution E is a 1‰~5% UP-S grade nitric acid solution.

8. The mass spectrometry measurement method according to claim 1, characterized in that, 89 The SrCl2 solution must meet the following requirements during detection. 90 Sr and 90 Y is in a long-term equilibrium state.

9. The mass spectrometry measurement method according to claim 1, characterized in that, When using the mass spectrometer, the strontium sensitivity at low resolution is greater than 2 × 10⁻⁶. 5 cps / (μg / L).

10. The mass spectrometry measurement method according to claim 5 or 6, characterized in that, The inductively coupled plasma mass spectrometer needs to be calibrated before sample introduction.

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