System for atomizing and spraying a liquid for transdermal delivery

Abstract

The present invention relates to a system (10) for atomizing and spraying a liquid (L) for transdermal delivery. The system (10) includes: a tank (100) for holding a liquid (L); a venturi tube (200) including a longitudinal central axis (X1) and an internal channel (210) extending along the axis (X1), wherein the internal channel (210) is fluidly connected to the tank (100) via an orifice (220) defined in the venturi tube (200), wherein the internal channel (210) includes a converging section (230), a diverging section (240), and a throat section (250) located between the converging section (230) and the diverging section (240); and a cylinder (300) including a longitudinal central axis (X2), an end wall (310) orthogonal to the axis (X2), a circumferential wall (320) extending from the end wall (310) along the axis (X2), and an outlet orifice (330) formed on the end wall (310). The cylinder (300) is fluidly connected to the inlet (232) of the converging section (230); a piston (400) is arranged in the cylinder (300) to be displaced along the axis (X2) in the cylinder (300), wherein the piston (400) cooperates with the cylinder (300) to define an intake space (V) in the cylinder (300), wherein the intake space (V) is fluidly communicated with the inlet (232) of the converging section (230) via the outlet (330); a drive unit (500) for displacing the piston (400) in a direction of increasing volume of the intake space (V); and an elastic member (600) deforms according to the displacement of the piston (400) and stores elastic energy therein while the piston (400) is displaced in a direction of increasing volume of the intake space (V). The drive unit (500) includes an elastic energy release mechanism (M) that releases elastic energy stored in an elastic member (600), thereby causing the piston (400) to move rapidly in the direction of decreasing volume of the intake space (V).

Description

Technical Field

[0001] This invention relates to a system for atomizing and spraying liquids (such as water, oil, emulsions, etc.) for transdermal delivery (particularly superficial transdermal delivery). The invention also relates to an apparatus for transdermal delivery of liquids, comprising such a system. Furthermore, the invention relates to a method for atomizing and spraying liquids for transdermal delivery. Background Technology

[0002] Cosmetic liquids, such as liquid emulsions containing hyaluronic acid, are typically applied to specific areas of the user's body, such as the face, hands, and arms, via superficial transdermal delivery (i.e., superficial-to-deep skin delivery). To deliver such liquids more effectively through the skin, it is desirable to atomize the liquid into micron-sized droplets and spray or spray them onto the desired areas of the user's body.

[0003] Several devices for atomizing and spraying cosmetic liquids are known in the prior art. Most of these conventional devices use high-pressure gas (e.g., carbon dioxide gas) or compressed air for atomizing and spraying the cosmetic liquid. Devices using high-pressure gas require replaceable air cylinders. A disadvantage of this cylinder method is that if the device is used frequently, the cylinder will quickly run out of gas and therefore require frequent replacement. On the other hand, devices using compressed air require an external source of compressed air, i.e., an external air compressor or external air pump. This makes the device as a whole relatively large. Such devices are difficult to move and transport and are not particularly suitable for easy operation. Therefore, there is a need for improved devices for atomizing and spraying liquids.

[0004] Examples of prior art that are at least partially related to the technology disclosed herein are as follows. JP1995022635 (MARUI) describes an electric spring-piston-gear mechanism for generating compressed air. US20180099104A1 (Gold NanoTech Inc.) describes a device for atomizing liquids by controlling the discharge of a certain amount of pressurized air using a solenoid valve. In this device, pressurized air passes through a venturi tube to atomize the liquid. However, JP1995022635 is only intended to generate compressed air for use in model air guns or air pistols to fire solid projectiles / projectiles. On the other hand, the device disclosed in US20180099104A1 is only configured to operate with externally supplied pressurized air. Summary of the Invention

[0005] In view of the foregoing, the object of the present invention is to provide a novel system and method for atomizing and spraying liquids (especially liquid formulations with high molecular weight) for transdermal delivery, as well as a novel device for transdermal delivery of liquids, the device comprising such a system.

[0006] In particular, the object of the present invention is to provide a novel system and apparatus for atomizing and spraying liquids for transdermal delivery that does not require a replaceable (i.e., single-use / disposable) power source such as a high-pressure air cylinder, and therefore can atomize and spray the liquid multiple times as needed by the user. Furthermore, the object of the present invention is to provide a novel system and apparatus for atomizing and spraying liquids for transdermal delivery that does not require an external supply source such as an air compressor or air pump, and is therefore compact (i.e., small physical footprint) and easy to move, transport, and operate.

[0007] To achieve the above objectives, the present invention provides a system for atomizing and spraying a liquid for transdermal delivery (particularly superficial transdermal delivery), as described below. That is, the system according to the invention comprises: (i) a canister for holding the liquid; (ii) a venturi tube including: a longitudinal central axis; and an internal channel extending along the longitudinal central axis, wherein the internal channel is fluidly connected to the canister via an orifice defined in the venturi tube, wherein the internal channel includes: a converging section; a diverging section; and a throat section located between the converging section and the diverging section; (iii) a cylinder including: a longitudinal central axis; an end wall orthogonal to the longitudinal central axis; a circumferential wall extending from the end wall along the same longitudinal central axis; and an outlet orifice formed on the end wall. The cylinder comprises: (iv) an outlet orifice fluidly connected to the inlet of the converging section of the venturi tube; (iv) a piston arranged in a cylinder to be movable along the longitudinal central axis of the cylinder, wherein the piston cooperates with the cylinder to define an intake space in the cylinder, wherein the intake space is fluidly communicated via the outlet orifice of the cylinder to the inlet of the converging section of the venturi tube; (v) a drive unit for displacing the piston in a direction of increasing volume of the intake space in the cylinder; and (vi) an elastic member deformable according to the displacement of the piston and storing elastic energy therein as the piston is displacing in a direction of increasing volume of the intake space. In this invention, the drive unit includes an elastic energy release mechanism that releases the elastic energy stored in the elastic member, thereby causing the piston to move rapidly in a direction of decreasing volume of the intake space.

[0008] The present invention also provides an apparatus for transdermal (particularly superficial transdermal) delivery of atomized liquids, the apparatus comprising: a system for atomizing and spraying a liquid for transdermal delivery as described above; and a housing at least partially housing the system.

[0009] The present invention also provides a method for atomizing and spraying a liquid for transdermal (particularly superficial transdermal) delivery. The method includes: (i) filling a canister with liquid, wherein the canister is fluidly connected to an internal channel of a venturi tube via an orifice defined in the venturi tube, wherein the internal channel of the venturi tube includes: a converging section; a diverging section; and a throat section located between the converging section and the diverging section; (ii) displacing a piston in a cylinder in a direction of increasing volume of an intake space in the cylinder, wherein the intake space is defined between the piston and an end wall of the cylinder, wherein an outlet orifice formed on the end wall of the cylinder is fluidly connected to the converging section of the venturi tube. (iii) As the piston is displaced in the direction of increasing volume of the intake space, the elastic member is deformed, the elastic member being arranged to deform according to the displacement of the piston and to store elastic energy therein; (iv) The elastic energy stored in the elastic member is released, thereby causing the piston to move rapidly in the direction of decreasing volume of the intake space; and (v) By utilizing the rapid movement of the piston, the air pushed out of the cylinder through the outlet hole of the cylinder end wall atomizes the liquid in the internal passage supplied from the can to the venturi tube and sprays it to the outside.

[0010] According to the present invention, the system comprises a compressed air source mainly consisting of a cylinder, a piston, an elastic member, a drive unit, and a Venturi tube in fluid communication with a fluid tank. In this invention, the drive unit utilizes the deformation of the elastic member to displace the piston within the cylinder, thereby drawing a predetermined amount of air into the cylinder. Subsequently, by immediately releasing the elastic energy stored in the elastic member, the piston is pushed back to its original position within the cylinder, compressing the air in the cylinder. As a result, high-pressure air is blown out at high speed from the cylinder's outlet and introduced into the internal channel of the Venturi tube. As the high-speed air passes through the Venturi tube, its internal pressure decreases, thus drawing a small amount of liquid from the tank into the internal channel of the Venturi tube. This small amount of liquid is thus atomized inside the Venturi tube by the action of the high-speed air and ejected from the Venturi tube along with the air. According to the present invention, it is possible to provide a jet of finely atomized liquid suitable for transdermal delivery (particularly superficial transdermal delivery), i.e., high-speed atomized liquid particles. As is well known to those skilled in the art, liquids with high molecular weights cannot effectively penetrate the skin through surface coating alone. According to the present invention, because the liquid is sufficiently finely pulverized, even liquids with high molecular weight can effectively penetrate into the skin. Here, superficial transdermal delivery means delivery down to the epidermis of the skin.

[0011] Furthermore, the systems, devices, and methods according to the invention do not require a replaceable (i.e., single-use / disposable) prime mover such as a high-pressure air cylinder for atomizing and spraying the liquid for transdermal delivery. Therefore, the systems, devices, and methods according to the invention can repeatedly atomize and spray the liquid. In addition, the systems, devices, and methods according to the invention do not require any external source such as an air compressor or air pump. That is, a high-speed air jet for atomizing and discharging the liquid can be generated internally. Therefore, the systems and devices can be compact enough to be handheld and easy to move, transport, and manipulate.

[0012] According to a preferred aspect of the invention, the piston may include: a longitudinal central axis; an end wall facing the cylinder; and a circumferential wall extending from the end wall along the longitudinal central axis. In this aspect, a rack extending along the longitudinal central axis may be formed on the outer surface of the circumferential wall of the piston. Furthermore, in this aspect, the drive unit may include a sector gear having teeth within a certain angular range, which meshes with the rack of the piston and linearly drives the rack. Furthermore, in this aspect, the combination of the sector gear and the rack may form an elastic energy release mechanism. According to this aspect, the mechanism for releasing the elastic energy stored in the elastic member can be manufactured to be particularly simple and robust. However, other mechanisms / devices that operate mechanically, electrically, electromagnetically, or fluidly for releasing the elastic energy stored in the elastic member may be suitably employed.

[0013] According to a preferred aspect of the invention, when the drive unit includes a sector gear, the drive unit may further include: an electric power source; and an electric motor electrically connected to the electric power source and directly or indirectly driving the sector gear rotatably. According to this aspect, the drive unit is particularly easy to operate.

[0014] According to a preferred aspect of the invention, when the drive unit includes an electric motor, the drive unit may further include: a pinion gear coupled to the output shaft of the electric motor; and one or more gears that transmit the rotational motion of the pinion gear to the sector gear to rotatably drive the sector gear. Specifically, the one or more gears may include: a bevel gear meshing with the pinion gear; and a spur gear meshing with both the bevel gear and the sector gear. According to this aspect, the output shaft of the motor and the rotation axis of the sector gear can be arranged orthogonally to each other, allowing the system to be as compact as possible. Furthermore, the use of this combination of gears helps to properly position the electric motor according to the desired overall shape of the device including the system.

[0015] According to a preferred aspect of the invention, when the drive unit comprises a bevel gear and a spur gear, the drive unit may further include a latch engaging with the spur gear, wherein the latch adjusts the rotation direction of the spur gear such that the spur gear rotates only in one direction. According to this aspect, the latch can prevent reverse rotation of the spur gear due to the restoring force of the deformed elastic member, and thus prevent the piston from retracting. As a result, it is possible to prevent the piston from unintentionally operating to expel air from the cylinder before the sector gear has rotated to its final position of disengagement from the piston rack (i.e., before the elastic member stores sufficient elastic energy).

[0016] According to a preferred aspect of the invention, when the drive unit includes a sector gear, the circumferential wall of the cylinder may be formed with a linear notch for exposing at least a portion of the rack of the piston, and the sector gear may mesh with the rack through the notch in the circumferential wall of the cylinder. According to this aspect, compared to the case where the circumferential wall of the cylinder does not have a notch for exposing at least a portion of the rack of the piston, the system can be more compact relative to the piston's displacement direction.

[0017] According to a preferred aspect of the invention, when the piston comprises an end wall facing the cylinder and a circumferential wall extending from the piston end wall, the elastic member can be a helical spring at least partially housed inside the piston. In this way, the system can become compact relative to the direction of piston displacement. Furthermore, according to a preferred aspect of the invention, the system may also include an elongated guide rod arranged to be surrounded by an elastic member such as a helical spring. In this case, the guide rod can at least partially enter the piston when the piston is displaced in a direction increasing the volume of the intake space. According to this aspect, while making the system compact relative to the direction of piston displacement, the elastic member (i.e., the helical spring) can be reliably compressed as the piston is displaced.

[0018] According to a preferred aspect of the invention, the canister can be fluidly connected to the throat section of the venturi tube, particularly via an orifice defined in the venturi tube. According to this aspect, particularly efficient liquid atomization is possible. Additionally, according to a preferred aspect of the invention, the venturi tube can be directly connected to the cylinder, such that the inlet of the converging section of the venturi tube and the outlet orifice of the cylinder are aligned with each other. According to this aspect, particularly efficient spraying of the atomized liquid is possible compared to the case where the inlet of the converging section of the venturi tube and the outlet orifice of the cylinder are connected, for example, via a separate line or conduit.

[0019] According to a preferred aspect of the invention, the ratio of the maximum inner diameter of the converging section of the venturi tube, the inner diameter of the throat section of the venturi tube, and the maximum inner diameter of the diverging section of the venturi tube can be from 1:0.1 to 0.7:1 to 1.5, based on the maximum inner diameter of the converging section. According to this aspect, a particularly satisfactory injection rate and injection volume of the atomized liquid can be obtained.

[0020] According to a preferred aspect of the invention, the liquid can be a cosmetic liquid for transdermal delivery (particularly superficial transdermal delivery). However, according to the invention, various liquids, including cosmetic liquids, can be atomized and sprayed. Liquids suitable for the invention have, for example, a density of 1 × 10⁻⁶. -4 Viscosities from 200 Pa·s to 200 Pa·s, more preferably less than 70 Pa·s. Attached Figure Description

[0021] The non-limiting and representative embodiments of the present invention will now be explained in detail with reference to the accompanying drawings.

[0022] Figure 1 This is a schematic block diagram of an apparatus for shallow transdermal delivery of atomized liquid according to an embodiment of the present invention.

[0023] Figure 2 This is a schematic diagram of a system for atomizing and spraying liquids for superficial transdermal delivery, which will be integrated with... Figure 1 The device shown is illustrated in cross-section, in which the venturi tube, piston, and cylinder, which are components of the system, are shown.

[0024] Figure 3 Is as Figure 2 An enlarged cross-sectional view of the tank and venturi tube of the system shown.

[0025] Figure 4 This shows the formation in a disassembled state. Figure 2 The diagram shows a perspective view of the gears in the drive force transmission mechanism of the drive unit of the system.

[0026] Figure 5 It is a system for atomizing and spraying liquids for superficial transdermal delivery, similar to Figure 2 The diagram shows the piston being shifted to the distal side (i.e., to the left in the diagram) by the driven unit.

[0027] Figure 6 It is a system for atomizing and spraying liquids for superficial transdermal delivery, similar to Figure 2 The diagram shows the piston being moved distally by the drive unit to its final position.

[0028] Figure 7 It is a system for atomizing and spraying liquids for superficial transdermal delivery, similar to Figure 2 The diagram shows the elastic energy stored in the coil spring being released, and the piston being pushed back to the proximal side (i.e., to the right in the diagram).

[0029] Figure 8 It is a system for atomizing and spraying liquids for superficial transdermal delivery, similar to Figure 2 The diagram shows the piston colliding with the end wall of the cylinder, and the high-speed air ejected from the cylinder causing a mist of liquid to be discharged from the outlet of the venturi tube. Detailed Implementation

[0030] Now refer to Figures 1 to 8 Some exemplary embodiments of the present invention are described below. In each figure, the scale ratio of the width, length, height, diameter, etc., of each element may not be constant and may differ from the actual scale ratio. It should be noted that in some figures, certain elements or features are drawn larger or smaller than they actually are for emphasis.

[0031] As used herein, direction-related terms such as “upper,” “lower,” “above,” “below,” “upward,” “downward,” “above,” “below,” “right,” and “left” should be understood in conjunction with the orientation of the system and device in the accompanying drawings, which may or may not match the actual orientation in use. Furthermore, it will be apparent to those skilled in the art that, in this specification, the term “far-side” or “towards the farthest” refers to a direction away from the Venturi tube from which the atomized liquid is sprayed or released. On the other hand, the term “proximal” or “towards the proximal” refers to a direction closer to the Venturi tube.

[0032] Figure 1 A device for superficial transdermal delivery of atomized liquids is schematically illustrated, which is an exemplary embodiment of the present invention. Generally indicated by reference numeral 1, the device mainly comprises a system for atomizing and spraying a liquid for transdermal delivery (generally indicated by reference numeral 10) and a housing 20 therein housing the system 10. In the illustrated embodiment, the housing 20 generally surrounds the entire system 10 (except for the outlet of the venturi tube for discharging the atomized liquid), although the housing 20 may only house at least a portion of the system 10. The target liquid for atomization and spraying by the device 1 is, in particular, a cosmetic liquid, such as a liquid emulsion containing hyaluronic acid to be delivered transdermally. However, the device 1 and therefore the system 10 can be used for atomizing and spraying water, oil, various emulsions, etc.

[0033] Apart from Figure 1 In addition, such as from Figure 2As can be better seen, system 10 includes a container 100 for holding a certain amount of liquid L (e.g., a few milliliters to several hundred milliliters of liquid L). The container 100 is preferably made of, for example, transparent plastic or glass, so that the contents and / or the amount of contents can be seen from the outside. Translucent or opaque materials can be used to manufacture the container 100. System 10 also includes a venturi tube 200, a cylinder 300 disposed adjacent to the venturi tube 200, and a piston 400 slidably arranged in the cylinder 300. The venturi tube 200 can be formed of a plastic material with sufficient rigidity, such as acrylonitrile-butadiene-styrene (ABS), polypropylene (PP), polycarbonate (PC), etc. The cylinder 300 and piston 400 can also be formed of the same material. Alternatively, both the cylinder 300 and piston 400 can be formed of a suitable metal (or metal alloy) material.

[0034] Further reference Figure 1 and Figure 2 The system 10 further includes a drive unit 500 operatively (i.e. mechanically) associated with the piston 400, an elastic member 600 (in this embodiment, a helical spring) also mechanically associated with the piston 400, and an elongated guide rod 700 arranged to be surrounded by the helical spring 600.

[0035] In particular, such as Figure 1 As shown, the drive unit 500 mainly includes a set of gears 500a and a power source assembly 500b, which are described in detail below. In this embodiment, the power source assembly 500b includes a battery (electric power source) 520, an electric motor 530, and a switch 580 inserted between the two. It should be noted that, for convenience, in addition to Figure 1 Apart from that, battery 520 and switch 580 are not shown in other figures.

[0036] As stated above, and as Figure 3 ( Figure 3 As shown in more detail in the cross-sectional view of the can 100 and the Venturi tube 200, the system 10 includes a can 100 for holding liquid L. In this embodiment, the can 100 is detachably connected to the Venturi tube 200 in a liquid-tight manner via a threaded connection. The can 100 has a flange 110 on its open side. The Venturi tube 200 also has a flange 260 corresponding to the flange 110 of the can 100. The can 100 is positioned above the Venturi tube 200, with its flange 110 contacting the flange 260 of the Venturi tube 200. This arrangement is particularly preferred because the effect of gravity facilitates the supply of liquid L to the Venturi tube 200 during operation of the system 10. However, the orientation of the can 100 relative to the Venturi tube 200 is not limited to this exemplary embodiment and can be appropriately changed as needed.

[0037] Further reference Figure 3The Venturi tube 200 includes a longitudinal central axis X1 and an internal channel 210 extending continuously along the longitudinal central axis X1. The internal channel 210 is fluidly connected to the tank 100 via an orifice 220 defined in the Venturi tube 200. Figure 3 As shown, the internal channel 210 includes a converging section 230, a diverging section 240, and a throat section 250 continuously connected along the longitudinal central axis X1. The throat section 250 is located between the converging section 230 and the diverging section 240. As explained above, the can 100 is specifically fluidly connected to the throat section 250 of the venturi tube 200 via an orifice 220. The inner diameter of the orifice 220 is such that when the pressure in the venturi tube 200 is equal to atmospheric pressure, the liquid L will not spontaneously decrease in the venturi tube 200 due to the viscosity of the liquid L.

[0038] The converging section 230 has an inlet 232 and an outlet 234 located at each of its two ends. The throat section 250 also has an inlet 252 and an outlet 254 located at each of its two ends. Furthermore, the diverging section 240 has an inlet 242 and an outlet 244 located at each of its two ends. The outlet 234 of the converging section 230 and the inlet 252 of the throat section 250 are smoothly and continuously connected to each other. Similarly, the outlet 254 of the throat section 250 and the inlet 242 of the diverging section 240 are smoothly and continuously connected to each other.

[0039] In this embodiment, the inner diameter D3 of the throat segment 250 is constant. The inner diameter (minimum inner diameter) D4 of the outlet 234 of the converging segment 230 is the same as the inner diameter D3 of the throat segment 250, and the inner diameter (minimum inner diameter) D5 of the inlet 242 of the diverging segment 240 is also the same as the inner diameter D3 of the throat segment 250. The inner diameter of the converging segment 230 decreases monotonically (linearly) toward the throat segment 250, while the inner diameter of the diverging segment 240 increases monotonically (linearly) away from the throat segment 250. However, the inner diameters of the converging segment 230 and the diverging segment 240 can decrease and increase curvilinearly, respectively.

[0040] Furthermore, in this embodiment, the ratio (i.e., D1∶D3∶D2) of the maximum inner diameter D1 of the converging section 230 (i.e., the inner diameter of the inlet 232), the inner diameter D3 of the throat section 250, and the maximum inner diameter D2 of the diverging section 240 (i.e., the inner diameter of the outlet 244) is 1∶0.1 to 0.7∶1 to 1.5. This is based on the maximum inner diameter D1 of the converging section 230. However, this ratio is only an example, and various other ratios may be used as needed.

[0041] Here, go to Figure 2The cylinder 300, as a component of system 1, includes a longitudinal central axis X2, an end (proximal) wall 310 facing the venturi tube 200 and orthogonal to the longitudinal central axis X2, and a circumferential wall 320 extending from the end wall 310 along the longitudinal central axis X2. That is, the cylinder 300 is a hollow body with one open end. Although not shown and not limited to, the cylinder 300 is fixedly supported by the frame of system 10 (e.g., a sub-housing of device 1 (not shown)). The cylinder 300 also includes an outlet port 330 formed on its end wall 310. The outlet port 330 is fluidly connected to the inlet 232 of the converging section 230 of the venturi tube 200. In this embodiment, the venturi tube 200 is directly connected to the cylinder 300 such that the inlet 232 of the converging section 230 of the venturi tube 200 and the outlet port 330 of the cylinder 300 are aligned with each other. However, if necessary, a configuration in which the inlet 232 of the converging section 230 and the outlet port 330 of the cylinder 300 are connected via a pipeline or conduit may also be adopted.

[0042] In cylinder 300, piston 400, as a component of system 1, is arranged to be smoothly displaceable along the longitudinal central axis X2 of cylinder 300. Piston 400 includes a longitudinal central axis X3, an end (proximal) wall 410 facing the end wall 310 of cylinder 300, and a circumferential wall 420 extending from the end wall 410 along the longitudinal central axis X3. Furthermore, piston 400 includes a rack 430 extending along the longitudinal central axis X3. The rack 430 is integrally formed on the outer surface of the circumferential wall 420 of piston 400, particularly in approximately half of the region on the distal side of the circumferential wall 420. Although in Figure 2 Not shown in the diagram, but the piston 400 cooperates with the cylinder 300 to define an intake space V within the cylinder 300 (see [reference]). Figure 5 , Figure 6 and Figure 7 The intake space V is in fluid communication with the inlet 232 of the converging section 230 of the venturi tube 200 via the outlet port 330 of the cylinder 300.

[0043] The piston 400 also includes an O-ring (packing) 440 made of, for example, an elastomeric material. The O-ring 440 fits into a circular groove 450 formed in the end wall 410 of the piston 400. The O-ring 440 serves to maintain an airtight seal between the piston 400 and the inner surfaces of the cylinder 300. In this embodiment, the cross-section of the piston 400 is a perfect circle in the end wall section where the O-ring 440 is located. However, in the circumferential wall section, the cross-section of the piston 400 is partially circular, with a portion of the circle cut off along a straight line parallel to its diameter. This is to ensure a flat surface on the outer circumferential surface of the piston for arranging the rack 430 as described above. Of course, in another embodiment, other shapes may be used for the cross-section of the circumferential wall section of the piston 400. Although not shown, in this embodiment, the system 10 also includes a mechanism or feature for preventing rotation of the piston 400 relative to the cylinder 300.

[0044] exist Figure 2 In the state shown, that is, when the end wall 310 of cylinder 300 and the end wall 410 of piston 400 are in contact with each other, the distal end of piston 400 protrudes slightly from the distal end of cylinder 300. In other words, the length of piston 400 along longitudinal central axis X3 is slightly greater than the length of circumferential wall 320 of cylinder 300 along longitudinal central axis X2. Therefore, in Figure 2 In the illustrated state, a portion of the rack 430, integrally formed on the outer peripheral surface of the piston 400, protrudes from the distal end of the cylinder 400. In this embodiment, the circumferential wall 320 of the cylinder 300 is formed with a linear notch 340 to expose at least a portion of the rack 430 of the piston 400. As explained in detail below, the sector gear 510 of the drive unit 500 meshes with the rack 430 through this notch 340 of the circumferential wall 320 of the cylinder 300.

[0045] As described above, system 10 includes a drive unit 500 and an elastic member 600 mechanically associated with each other. The drive unit 500 can displace the piston 400 distally, that is, in the direction of increasing volume of the intake space V in cylinder 300. On the other hand, the elastic member 600 is arranged to deform according to the displacement of the piston 400, and stores elastic energy (mechanical potential energy) in the elastic member 600 when the piston 400 is displaced distally (i.e., in the direction of increasing volume of the intake space V). Therefore, system 10 of this embodiment can be referred to as a "spring-loaded system". In this embodiment, as described above, the elastic member 600 is a helical spring, which is at least partially (e.g., about half) housed inside the hollow piston 400.

[0046] The drive unit 500 further includes an elastic energy release mechanism M. In this embodiment, the elastic energy release mechanism M is configured to release the elastic energy stored in the elastic member 600 at regular intervals, thereby causing the piston 400 to move rapidly (or surge) proximally (i.e., in the direction of decreasing volume of the intake space V). More specifically, the drive unit 500 includes a sector gear 510 having teeth only within a certain angular range (e.g., 90° to 300°). The sector gear 510 is arranged to mesh with the rack 430 of the piston 400 and drive the rack 430 linearly in one direction (i.e., to the left in the figure). In this embodiment, the combination of the sector gear 510 and the rack 430 forms the elastic energy release mechanism M for releasing the stored elastic energy at regular intervals. That is, at the moment when the last tooth of the sector gear 510 disengages from the last tooth of the rack 430, the constraint on the piston 400 is released, and thus the elastic energy stored in the elastic member 600 is also immediately released. However, in another embodiment, another type of elastic energy release mechanism can be adapted, and it can be configured to release the elastic energy stored in the elastic member 600 only when desired.

[0047] As already explained, the drive unit 500 includes an electric power source 520, such as a rechargeable battery like a lithium-ion battery. Additionally, as explained above, the drive unit 500 includes an electric motor 530 electrically connected to the electric power source 520 and indirectly (i.e., via a gear train for power transmission) rotatably driving the sector gear 510. As described above, the electric power source 520, the electric motor 530, and the switch 580 disposed between them constitute the power source assembly 500b of the drive unit 500. In this embodiment, the sector gear 510 is driven by the electric motor 530 via the gear set 500a in only one direction (i.e., in...). Figure 2 (It rotates counterclockwise). In another embodiment, the sector gear 510 can be directly driven by an electric motor 530. However, in this case, due to the need for a motor with high torque and therefore large size, it is desirable to drive the sector gear 510 via a suitable reduction mechanism consisting of a gear train, as illustrated herein.

[0048] Here, for reference Figure 4The gear train constituting the reduction mechanism of the drive unit 500 will be described, namely the gear set 500a of the drive unit 500 as described above. The gear set 500a of the drive unit 500 includes a pinion 540 (bevel gear type) which is fixedly coupled to the output shaft 532 of the electric motor 530. Furthermore, the gear set 500a of the drive unit 500 includes two types of gears 550 and 560, which transmit the rotational motion of the pinion 540 to the sector gear 510 to rotatably drive the sector gear 510. In this embodiment, these gears 550, 560, and the sector gear 510 are rotatably supported by the frame (not shown) of the system 10 (i.e., the sub-housing of the device 1). Since the electric motor 530 is fixedly supported by the frame (not shown) of the system 10, the pinion 540 is also rotatably supported by the frame (not shown) of the system 10. In another embodiment, gears 510, 550, and 560 may be rotatably supported by the housing 20 of the device 1 itself.

[0049] Further reference Figure 4 The gear 550 meshing with the pinion 540 is a bevel gear. On the other hand, the gear 560 meshing with both the bevel gear 550 and the sector gear 510 is a spur gear. Here, the spur gear 560 serves as an intermediate gear. In this embodiment, both the sector gear 510 and the bevel gear 550 have a structure in which two types of gear drive portions are stacked along the direction of the rotation axis. The sector gear 510 includes a first portion 512 having teeth only within a certain angular range along its root circle. Furthermore, the sector gear 510 includes a second portion 514 integrally connected to the first portion 512. The second portion 514 of the sector gear 510 (i.e., the spur gear portion) includes teeth along the entire circumference of its root circle. The diameter of the tip circle of the second portion 514 is smaller than the diameter of the tip circle of the first portion 512.

[0050] The bevel gear 550 also includes a first portion 552 and a second portion 554. The first portion 552 contains a row of teeth circumferentially arranged on a conical surface. The second portion 554 is integrally connected to the first portion 552 and consists of spur gears with a diameter smaller than the minimum diameter of the first portion 552. A pinion 540, fixedly attached to the output shaft 532 of the electric motor 530, meshes with the first portion 552 of the bevel gear 550, and the second portion 554 of the bevel gear 550, which rotates integrally with it, meshes with the spur gear 560. Furthermore, the spur gear 560 meshes with the second portion 514 of the sector gear 510. As a result, the high-speed rotation of the pinion 540 causes the sector gear 510 to rotate at a predetermined lower speed (e.g., a few revolutions per second). The piston 400 is displaced in the distal direction at regular intervals by the resulting rotation of the sector gear 510. In this embodiment, the number of teeth on the rack 430 of the piston 400 is approximately equal to the number of teeth on the first portion 512 of the sector gear 510, but the invention is not limited thereto.

[0051] Here, refer again Figure 2 The drive unit 500 also includes a latch 570 that meshes with the spur gear 560. The latch 570 is arranged to adjust the direction of rotation of the spur gear 560 such that the spur gear 560 rotates only in one direction (i.e., in...). Figure 2 (Clockwise) Rotation. In another embodiment, it is also conceivable to engage the latch 570 with any gear other than the spur gear 560. The latch 570 is not an essential component of the system 10.

[0052] Further reference Figure 2 System 10 further includes an elongated spring guide rod 700, which is arranged to be surrounded by a helical spring 600. In this embodiment, the base end 710 of the guide rod 700 is supported by the frame of system 10 (not shown) (i.e., the sub-housing of device 1). In another embodiment, the spring guide rod 700 may be supported by the housing 20 of device 1 itself. The spring guide rod 700 is arranged such that when the piston 400 is displaced distally (i.e., in the direction of increasing volume of the intake space V), the spring guide rod 700 at least partially enters the piston 400.

[0053] In the following text, reference will be made to Figure 2 , Figures 5 to 8 The operation of the system 10 for atomizing and spraying liquids, configured as described above, is described, as well as the method for atomizing and spraying liquids for transdermal delivery (assuming that the canister 100 is initially empty).

[0054] Before atomizing and spraying the liquid, canister 100 is filled with liquid L. This process can be performed with canister 100 removed from venturi tube 200. Next, with system 10 and therefore device 1 upside down, canister 100 is screwed onto venturi tube 200 to connect them to each other. Then, system 10 and therefore device 1 are returned to their normal operating position, in which canister 100 is positioned above venturi tube 200. As a result of this process, canister 100 is fluidly connected to the internal channel 210 of venturi tube 200 via orifice 220 defined in venturi tube 200. This completes the preparation for atomizing and discharging the liquid (see...). Figure 2 If a can with an openable lid is used (in this case, the lid is located opposite the flange 110 of the can 100), the can 100 can be filled with liquid without removing it from the venturi tube 200.

[0055] Next, piston 400 moves distally within cylinder 300 (i.e., in the direction of increasing volume of the intake space V defined within cylinder 300). This process is performed automatically by turning on switch 580. That is, as described above, when switch 580 is turned on, electric motor 530 rotates, and its rotational force is transmitted to sector gear 510 via a gear train consisting of gears 550 and 560. Since sector gear 510 meshes with rack 430 of piston 400, rotation of sector gear 510 causes piston 400 to move distally as described above. Figure 5 The diagram shows a state in which the piston 400 is displaced only a short distance in the distal direction by the drive unit 500.

[0056] As the piston 400 moves in the direction of increasing volume of the intake space V, the elastic member 600 (i.e., the coil spring) deforms simultaneously and gradually. As described above, the elastic member 600 is arranged to deform linearly according to the displacement of the piston 400. Therefore, during this process, the elastic member 600 stores elastic energy therein. Figure 6 The diagram shows the state in which the piston 400 has been displaced distally by the drive unit 500 to its final position. This state occurs just before the last tooth in a row of teeth of the sector gear 510 (viewed in the rotational direction) and the last tooth of the rack 430 (viewed in the displacement direction) disengage, and the elastic energy stored in the coil spring 600 is maximized.

[0057] When sector gear 510 from Figure 6When the state shown is rotated a small angle further, the sector gear 510 and the rack 430 (more specifically, the last tooth of the sector gear 510 and the last tooth of the rack 430) disengage. As a result, the piston 400 is now free to move. Therefore, the elastic energy stored in the elastic member 600 is immediately released, causing the piston 400 to move rapidly toward the proximal side (i.e., in the direction in which the volume of the intake space V decreases). Figure 7 This shows the state in which the piston 400 is pushed only a short distance proximally within the cylinder 300.

[0058] exist Figure 7 In the scenario shown, air present in the intake space V of cylinder 300 is compressed by piston 400 and moves at high speed from the outlet port 330 of cylinder 300 into venturi tube 200. As the air travels through venturi tube 200, the air velocity increases, especially in its throat section 250. As a result, the pressure in throat section 250 decreases, causing a small amount of liquid L in canister 100 to be drawn into passage 210 through orifice 220 of venturi tube 200. This small amount of liquid L is atomized inside venturi tube 200 by air (which is pushed out of cylinder 300 by piston 400 and moves at high speed) and discharged to the outside through outlet 244 of venturi tube 200. Figure 8 The diagram shows a state in which the piston 400 collides with the end wall 310 of the cylinder 300 and the high-speed air ejected from the cylinder 300 causes a mist of liquid L to be discharged from the outlet of the venturi tube 200.

[0059] In this embodiment, unless switch 580 is turned off, electric motor 530 will continue to rotate, and therefore sector gear 510 will also continue to rotate. Thus, upon reaching... Figure 8 After the state shown, the sector gear 510 immediately re-engages with the rack 430 of the piston 400. As a result, system 10 returns to... Figure 2 The initial state is shown in the diagram. Therefore, when switch 580 remains on, system 10 intermittently (at intervals corresponding to the rotational speed of sector gear 510) atomizes the liquid L in canister 100 and discharges it as atomized liquid particles to the outside through venturi tube 200.

[0060] As described above, system 10 and therefore device 1 comprise a compressed air source consisting primarily of a cylinder 300, a piston 400, an elastic member 600, a drive unit 500, and a venturi tube 200 in fluid communication with the fluid tank 100. As the elastic member 600 deforms, the drive unit 500 displaces the piston 400 within the cylinder 300, thus drawing a predetermined amount of air into the cylinder 300. Subsequently, by releasing the elastic energy stored in the elastic member 600, the piston 400 is pushed back to its original position within the cylinder 300, compressing the air within the cylinder 300. As a result, high-pressure air is blown out at high speed from the outlet port 330 of the cylinder 300 and supplied to the internal passage 210 of the venturi tube 200. As the high-speed air passes through the venturi tube 200, particularly the throat section 250 (i.e., the constriction), the internal pressure decreases, thus drawing a small amount of liquid L from the tank 100 into the internal passage 210 of the venturi tube 200. The small amount of liquid L inhaled is thus atomized inside the Venturi tube 200 by the action of high-speed air and ejected from the Venturi tube 200 along with the air. In this way, it is possible to provide a jet of finely atomized liquid, i.e., high-speed atomized liquid particles (very fine droplets), which is suitable for superficial transdermal delivery to the upper epidermal layer of the skin.

[0061] Furthermore, system 10 and therefore device 1 do not require a replaceable (i.e., single-use / disposable) prime mover such as a high-pressure air cylinder for atomizing and spraying the liquid for transdermal delivery. Therefore, system 10 and therefore device 1 can repeatedly atomize and spray the liquid L. In addition, system 10 and therefore device 1 do not require an external source such as an air compressor or air pump. That is, a high-speed air jet for atomizing and discharging the liquid is generated internally. Therefore, system 10 and therefore device 1 can be compact and easy to move, transport, and carry.

[0062] The following lists specific data for an example of a system according to the above embodiments. However, the invention is not limited to these values:

[0063] - Cylinder inner diameter: 10 to 30 mm;

[0064] - Spring constant of elastic components: 20 to 70 N / m;

[0065] - The natural length of the elastic component: 10 to 30 cm;

[0066] -Outer diameter of elastic components: 5 to 15 mm;

[0067] - The diameter of the cylinder outlet hole: 1 to 10 mm, especially 5 mm;

[0068] - Maximum inner diameter of the converging section of the venturi tube: 1 to 10 mm, especially 5 mm;

[0069] - Maximum inner diameter of the diverging section of the Venturi tube: 7 mm when the maximum inner diameter of the converging section of the Venturi tube is 5 mm.

[0070] - Inner diameter of the throat section of the Venturi tube: 3.4 mm when the maximum inner diameter of the converging section of the Venturi tube is 5 mm;

[0071] - The inner diameter of the orifice of the Venturi tube is 0.6-1.2 mm, and in particular, it is 0.6 mm when the maximum inner diameter of the converging section of the Venturi tube is 5 mm.

[0072] - Maximum pressure of compressed air in the cylinder: 0.55 MPa;

[0073] - Atomized droplet size: less than 10μm;

[0074] - The velocity of the atomized droplets at the outlet of the Venturi tube: at least 150 m / s, regardless of the molecular weight of the liquid;

[0075] - The volume of liquid that can be delivered: 20 ml / injection; and

[0076] - Maximum frequency of liquid delivery (injection): twice per second.

[0077] Preferred embodiments of the present invention have been explained in detail above with reference to the accompanying drawings. However, the present invention is not limited to these embodiments, and various modifications and changes can be made to the above embodiments without departing from the scope of the present invention, and such modifications and changes are also included within the scope of the present invention.

Claims

1. A system (10) for atomizing and spraying a liquid (L) for transdermal delivery, the system (10) comprising: A container (100) for holding the liquid (L); A venturi tube (200) includes: a longitudinal central axis (X1); and an internal channel (210) extending along the longitudinal central axis (X1), wherein the internal channel (210) is fluidly connected to the tank (100) via an orifice (220) defined in the venturi tube (200), wherein the internal channel (210) includes: a converging section (230); a diverging section (240); and a throat section (250) located between the converging section (230) and the diverging section (240); A cylinder (300) includes: a longitudinal central axis (X2); an end wall (310) orthogonal to the longitudinal central axis (X2); a circumferential wall (320) extending from the end wall (310) along the longitudinal central axis (X2); and an outlet orifice (330) formed on the end wall (310), wherein the outlet orifice (330) is fluidly connected to the inlet (232) of the converging section (230) of the venturi tube (200); A piston (400) is arranged in the cylinder (300) to be displaced within the cylinder (300) along the longitudinal central axis (X2) of the cylinder (300), wherein the piston (400) cooperates with the cylinder (300) to define an intake space (V) in the cylinder (300), wherein the intake space (V) is in fluid communication with the inlet (232) of the converging section (230) of the venturi tube (200) via the outlet port (330) of the cylinder (300); A drive unit (500) for displacing the piston (400) in a direction that increases the volume of the intake space (V) in the cylinder (300); and An elastic member (600) deforms according to the displacement of the piston (400) and stores elastic energy in the elastic member (600) as the piston (400) is displaced in the direction of increasing volume of the intake space (V). The drive unit (500) includes an elastic energy release mechanism (M) that releases the elastic energy stored in the elastic member (600), thereby causing the piston (400) to move rapidly in the direction of decreasing volume of the intake space (V). The converging section (230) has an inlet (232) and an outlet (234) located at each of its two ends, the throat section (250) has an inlet (252) and an outlet (254) located at each of its two ends, and the diverging section (240) has an inlet (242) and an outlet (244) located at each of its two ends, wherein the outlet (234) of the converging section (230) and the inlet (252) of the throat section (250) are smoothly and continuously connected to each other, and wherein the outlet (254) of the throat section (250) and the inlet (242) of the diverging section (240) are smoothly and continuously connected to each other, and The piston (400) includes: a longitudinal central axis (X3); an end wall (410) facing the end wall (310) of the cylinder (300); and a circumferential wall (420) extending from the end wall (410) along the longitudinal central axis (X3), wherein a rack (430) extending along the longitudinal central axis (X3) is formed on the outer surface of the circumferential wall (420) of the piston (400), wherein the drive unit (500) includes a sector gear (510) having teeth only within a certain angular range, the sector gear (510) meshing with the rack (430) of the piston (400) and linearly driving the rack, wherein the combination of the sector gear (510) and the rack (430) forms the elastic energy release mechanism (M).

2. The system (10) according to claim 1, wherein, The drive unit (500) further includes: an electric power source (520); and an electric motor (530) electrically connected to the electric power source (520) and directly or indirectly rotatably driving the sector gear (510).

3. The system (10) according to claim 2, wherein, The drive unit (500) further includes: a pinion (540) connected to the output shaft (532) of the electric motor (530); and one or more gears (550, 560) that transmit the rotational motion of the pinion (540) to the sector gear (510) to rotate the sector gear.

4. The system (10) according to claim 3, wherein, The one or more gears (550, 560) include: a bevel gear (550) that meshes with the pinion (540); and a spur gear (560) that meshes with both the bevel gear (550) and the sector gear (510).

5. The system (10) according to claim 4, wherein, The drive unit (500) further includes a latch (570) that meshes with the spur gear (560), wherein the latch (570) adjusts the rotation direction of the spur gear (560) so that the spur gear (560) rotates in only one direction.

6. The system (10) according to claim 1, wherein, The circumferential wall (320) of the cylinder (300) is formed with a linear notch (340) for exposing at least a portion of the rack (430) of the piston (400), wherein the sector gear (510) meshes with the rack (430) through the notch (340) of the circumferential wall (320) of the cylinder (300).

7. The system (10) according to claim 1, wherein, The elastic member (600) is a helical spring that is at least partially housed inside the piston (400).

8. The system (10) according to claim 7 further includes an elongated guide rod (700) arranged to be surrounded by the elastic member (600), wherein, When the piston (400) is displaced in the direction of increasing volume of the intake space (V), the guide rod (700) enters the piston (400) at least partially.

9. The system (10) according to claim 1, wherein, The can (100) is fluidly connected to the throat section (250) of the venturi tube (200).

10. The system (10) according to claim 1, wherein, The venturi tube (200) is directly connected to the cylinder (300) such that the inlet (232) of the converging section (230) of the venturi tube (200) and the outlet hole (330) of the cylinder (300) are aligned with each other.

11. The system (10) according to claim 1, wherein, Based on the maximum inner diameter (D1) of the converging section (230), the ratio of the maximum inner diameter (D1) of the converging section (230) of the venturi tube (200), the inner diameter (D3) of the throat section (250) of the venturi tube (200), and the maximum inner diameter (D2) of the diverging section (240) of the venturi tube (200) is 1:0.1 to 0.7:1 to 1.

5.

12. The system (10) according to claim 1, wherein, The liquid (L) is a cosmetic liquid to be delivered transdermally.

13. A device (1) for transdermal delivery of atomized liquid, said device (1) comprising: The system (10) according to any one of claims 1 to 12; as well as A housing (20) that at least partially houses the system (10).

14. A method for atomizing and spraying a liquid (L) for transdermal delivery, the method comprising: A container (100) is filled with liquid (L), wherein the container (100) is fluidly connected to an internal channel (210) of a venturi tube (200) via an orifice (220) defined in the venturi tube (200), wherein the internal channel (210) of the venturi tube (200) includes: a converging section (230); a diverging section (240); and a throat section (250) located between the converging section (230) and the diverging section (240); The piston (400) is displaced in the cylinder (300) in a direction that increases the volume of the intake space (V) in the cylinder (300), wherein the intake space (V) is defined between the piston (400) and the end wall (310) of the cylinder (300), wherein the outlet hole (330) formed on the end wall (310) of the cylinder (300) is fluidly connected to the inlet (232) of the converging section (230) of the venturi tube (200); As the piston (400) is displaced in the direction of increasing volume of the intake space (V), the elastic member (600) is deformed, the elastic member (600) being arranged to deform according to the displacement of the piston (400) and to store elastic energy therein; The elastic energy stored in the elastic member (600) is released, causing the piston (400) to move rapidly in the direction of decreasing volume of the intake space (V); and By utilizing the rapid movement of the piston (400), air pushed out from the cylinder (300) through the outlet hole (330) of the end wall (310) of the cylinder (300) atomizes and sprays the liquid (L) supplied from the tank (100) to the internal channel (210) of the venturi tube (200) into the outside. The converging section (230) has an inlet (232) and an outlet (234) located at each of its two ends, the throat section (250) has an inlet (252) and an outlet (254) located at each of its two ends, and the diverging section (240) has an inlet (242) and an outlet (244) located at each of its two ends, wherein the outlet (234) of the converging section (230) and the inlet (252) of the throat section (250) are smoothly and continuously connected to each other, and wherein the outlet (254) of the throat section (250) and the inlet (242) of the diverging section (240) are smoothly and continuously connected to each other, and The piston (400) includes: a longitudinal central axis (X3); an end wall (410) facing the end wall (310) of the cylinder (300); and a circumferential wall (420) extending from the end wall (410) along the longitudinal central axis (X3), wherein a rack (430) extending along the longitudinal central axis (X3) is formed on the outer surface of the circumferential wall (420) of the piston (400), wherein the rack (430) is used to move the piston (400) in a direction that increases the volume of the intake space (V) in the cylinder (300). The drive unit (500) of the piston (400) includes a sector gear (510) having teeth only within a certain angular range, the sector gear (510) meshing with the rack (430) of the piston (400) and linearly driving the rack, wherein the combination of the sector gear (510) and the rack (430) forms an elastic energy release mechanism (M), the elastic energy release mechanism (M) releasing the elastic energy stored in the elastic member (600), thereby causing the piston (400) to move rapidly in the direction of decreasing volume of the intake space (V).

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