Stable emulsions and methods of making and using the same
By adding charged particles to aluminum microgel adjuvants to form a composite stabilizer and adjusting the pH value to prepare an oil-in-water emulsion with smaller particle size, the problem of poor cellular immune efficacy of existing aluminum microgel adjuvants in vaccines is solved, and a more stable and efficient immune response is achieved.
CN116672311BActive Publication Date: 2026-05-26INSTITUTE OF PROCESS ENGINEERING CHINESE ACADEMY OF SCIENCES
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- INSTITUTE OF PROCESS ENGINEERING CHINESE ACADEMY OF SCIENCES
- Filing Date
- 2023-07-11
- Publication Date
- 2026-05-26
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Figure CN116672311B_ABST
Abstract
This invention discloses a stabilized emulsion, its preparation method, and its uses. The invention stabilizes the emulsion using aluminum hydroxide microgels. The stabilized emulsion comprises an oil phase, an aqueous phase, and a composite stabilizer adsorbed at the oil-water interface or dispersed in the aqueous phase. Adding charged particles that interact with the aluminum hydroxide microgels to the stabilizer further enhances the emulsion's stability and immune response. The stabilized emulsion of this invention can be used as an oil-emulsion adjuvant, exhibiting uniform particle size, good dispersibility, good stability, and tunable properties. It can simultaneously activate humoral and cellular immune responses and can be used as a vaccine adjuvant or in vaccine delivery systems for preventative and therapeutic vaccines.
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