Probe layout method and equipment for high-density blood oxygenation sampling based on brain imaging technology

Abstract

This application relates to the field of medical imaging technology, and more particularly to a probe layout method and device for high-density blood oxygenation sampling based on brain imaging technology. The method includes: selecting a light source probe sleeve and a detector probe sleeve with a diameter ≤1.5cm; geometrically, arranging the light source probe and detector probe in pairs adjacent to each other, with each pair of light source probes and each pair of detector probes arranged alternately. This application solves the problem that in traditional probe layout structures, the light source and detector appear alternately, and high-density probe layout cannot be achieved due to the diameter limitations of existing probe sleeves, resulting in low spatial resolution of the test channel in near-infrared spectral imaging technology.

Description

Technical Field

[0001] This application relates to the field of medical imaging technology, and in particular to a probe layout method and device for high-density blood oxygenation sampling based on brain imaging technology. Background Technology

[0002] With the continuous development of brain imaging technology, near-infrared brain functional imaging technology has become an indispensable new generation imaging modality in brain function research and clinical diagnosis. Near-infrared brain functional imaging technology can detect information on oxygenated hemoglobin, deoxygenated hemoglobin, and total oxygenated hemoglobin in the cerebral cortex. The detection of brain blood oxygenation information is mainly based on the change in near-infrared light intensity between the emitted light source and the detector, and the blood oxygen concentration is calculated based on the Lambert-Beer law.

[0003] Specifically, the tester wears a cap with several through-holes, each housing a probe sleeve. Currently, the diameter of these probe sleeves is often greater than 1.5 cm. During testing, several sets of corresponding light source probes and detector probes are installed inside the probe sleeves. The near-infrared light emitted by the light source must penetrate the hair, scalp, and skull before being scattered by the subcortical blood vessels of the brain, before it can be detected by the detector. Each near-infrared light source probe and detector probe forms a test channel. Different layouts of the light source and detector probes will result in different distributions of the test channels. During testing, on the one hand, to accurately detect blood oxygenation information in the subcortical tissue of the tester's skull, the distance between the light source and the detector should be no less than 3 cm. Otherwise, the detected blood oxygenation information is mostly superficial scalp blood oxygenation rather than subcortical cerebral blood oxygenation information, failing to reflect deeper changes in blood oxygen concentration and neural activity. On the other hand, at a 3 cm distance, the near-infrared light signal detected by the detector is often very weak. If the distance between the light source and the detector is further increased, the detector will not receive a valid near-infrared light signal, rendering the blood oxygenation data of that test channel invalid. Therefore, 3cm is generally used as the standard light source-detection distance.

[0004] Currently, there are basically three types of traditional probe layout structures. The first type is the staggered probe layout, as shown in [reference]. Figure 1 The spacing between each pair of light source and detector is 3cm. The numbers between the probes indicate the test channels. The second type is a probe layout with vertical and horizontal orientation, as shown in the reference. Figure 2 The first type has the light source and probe located on the horizontal / vertical sides respectively, with only the point between the two rows of probes serving as the test channel. The second type is a star-shaped probe layout, as shown in the reference... Figure 3 With the light source as the center point, detectors are evenly arranged around the light source, forming a ring-shaped layout for the test channel.

[0005] However, in traditional probe layouts, the light source and detector appear alternately, and the high-density layout of the probe cannot be achieved due to the diameter limitations of the existing probe sleeve, resulting in low spatial resolution of the test channel for near-infrared spectral imaging technology. Summary of the Invention

[0006] This application provides a probe layout method and device for high-density blood oxygenation sampling based on brain imaging technology. It solves the problem that in traditional probe layouts, the light source and detector appear alternately, and high-density probe layout cannot be achieved due to the diameter limitations of existing probe sleeves, resulting in low spatial resolution of the test channel in near-infrared spectral imaging technology. This application provides the following technical solution:

[0007] In a first aspect, this application provides a probe layout method for high-density blood oxygenation sampling based on brain imaging technology, the method comprising:

[0008] Select light source probe sleeves and detector probe sleeves with a diameter ≤ 1.5cm;

[0009] Geometrically, the light source probes and detector probes are arranged in pairs adjacent to each other, with each pair of light source probes and each pair of detector probes arranged in an alternating pattern.

[0010] In one specific implementation scheme, the distance between the light source probe and the detector probe can be adjusted according to the intensity of the light source power, and the adjustment range of the probe distance is ≥1.5cm.

[0011] In one specific implementation, the arrangement of the light source probes and detector probes in a geometrical dimension, with each pair of light source probes and each pair of detector probes arranged in an alternating manner, includes:

[0012] The light source probe and the detector probe are arranged in a vertical direction, with the probes arranged in several diagonal columns. The probes are distributed in a diamond shape as a whole, and each diagonal column is arranged in a vertical direction with two light source / detector probes alternating.

[0013] In one specific implementation scheme, the distance between any two adjacent probes in any diagonal column is 1.5 cm, and the distance between the light source probe and its corresponding detector probe in any two adjacent diagonal columns is 3 cm.

[0014] In one specific implementation, the arrangement of the light source probes and detector probes in a geometrical dimension, with each pair of light source probes and each pair of detector probes arranged in an alternating manner, includes:

[0015] The probes are arranged in several rows, forming a matrix distribution. Each row is arranged horizontally with two light source / detector probes alternating.

[0016] In a specific feasible implementation, the spacing between any two adjacent probes in any row along the horizontal direction is 1.5cm, and the spacing between the light source probe and its corresponding detector probe in any two adjacent rows is 3cm.

[0017] In one specific implementation, the light source / detector probe sleeve with a diameter ≤1.5cm can be threaded onto the head cap.

[0018] Secondly, this application provides a headgear for applying a probe layout method for high-density blood oxygenation sampling based on brain imaging technology as described in any one of claims 1 to 7.

[0019] Thirdly, this application provides an electronic device, the device including a processor and a memory; the memory stores a program, the program being loaded and executed by the processor to implement a probe layout method for high-density blood oxygenation sampling based on brain imaging technology as described in any one of claims 1 to 7.

[0020] Fourthly, this application provides a computer-readable storage medium storing a program that, when executed by a processor, is used to implement a probe layout method for high-density blood oxygenation sampling based on brain imaging technology as described in any one of claims 1 to 7.

[0021] In summary, the beneficial effects of this application include at least the following: While maintaining a 3cm spacing between the light source probe and the detector probe, this application does not affect the detection depth of the light source / detector probe or its ability to detect scalp blood oxygenation information, thus ensuring signal quality as much as possible. On one hand, it achieves higher spatial resolution blood oxygenation detection, which is beneficial for obtaining more brain blood oxygenation information. On the other hand, it ensures the uniformity of probe spacing within the same horizontal or diagonal column, with a spacing of 1.5cm for all probes. The layout of this application can be rearranged horizontally or vertically, or extended vertically, depending on the number of light source / detector probe pairs and actual application requirements. Neither of the two high-density probe layouts in this application has a fixed number of probe pairs or arrangement angle. By cleverly designing to ensure a 3cm spacing between each pair of light source / detector probes, the spatial resolution of the detection channel can be improved. It also has higher adaptability, allowing for corresponding changes in the layout as light source technology continues to advance, to suit more probe detection scenarios.

[0022] By selecting a light source / detector probe sleeve with a diameter ≤1.5cm and then reflecting the geometric dimensions in both the horizontal and vertical dimensions, so that each pair of light source / detector probes is adjacent and each pair of light source probes is staggered with each pair of detector probes, the problem of low spatial resolution of the test channel of near-infrared spectral imaging technology can be solved in the traditional probe layout structure, where the light source and detector appear alternately and the high-density layout of the probe cannot be achieved under the diameter limitation of the existing probe sleeve.

[0023] The above description is only an overview of the technical solution of this application. In order to better understand the technical means of this application and to implement it in accordance with the contents of the specification, the preferred embodiments of this application are described in detail below with reference to the accompanying drawings. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the staggered probe layout in existing technology.

[0025] Figure 2 This is a schematic diagram of the probe's longitudinal and transverse layout in existing technology.

[0026] Figure 3 This is a schematic diagram of the star-shaped structure layout of the probe in the existing technology.

[0027] Figure 4 This is a schematic flowchart of the probe layout method for high-density blood oxygenation sampling based on brain imaging technology in the embodiments of this application.

[0028] Figure 5 This is a schematic diagram of the high-density layout of the probe in this embodiment. Figure 1 .

[0029] Figure 6 This is a schematic diagram of the high-density layout of the probe in this embodiment. Figure 2 .

[0030] Figure 7 This is a structural block diagram of an electronic device with a probe layout for high-density blood oxygenation sampling based on brain imaging technology, as described in this application embodiment. Detailed Implementation

[0031] The specific embodiments of this application will be described in further detail below with reference to the accompanying drawings and examples. The following examples are used to illustrate this application, but are not intended to limit the scope of this application.

[0032] First, let me introduce some of the terms used in this application.

[0033] Brain imaging technology can detect brain blood sample protein information, which can be applied to multiple fields such as disease diagnosis, brain-computer interface, adjuvant therapy, e-sports, and marketing.

[0034] Lambert-Beer law is a fundamental law of spectrophotometry, describing the relationship between the intensity of absorption of light of a certain wavelength by a substance and the concentration of the absorbing substance and the thickness of the liquid layer.

[0035] Optionally, this application uses the probe layout method for high-density blood oxygenation sampling based on brain imaging technology provided in various embodiments as an example for description in an electronic device. The electronic device is a terminal or a server. The terminal can be a mobile phone, computer, tablet computer, scanner, electronic eye, surveillance camera, etc. This embodiment does not limit the type of electronic device.

[0036] The usage scenario of this embodiment is as follows: The person being tested wears a headgear with several through holes. Each through hole is fitted with a light source / detector probe sleeve according to the layout structure of the light source / detector probe. During testing, several sets of corresponding light source probes and detector probes are installed in the probe sleeves. The near-infrared light emitted by the light source penetrates the hair, scalp, and skull, and is then scattered by the subcortical blood vessels of the brain and detected by the detector.

[0037] Reference Figure 4 This is a flowchart illustrating a probe layout method for high-density blood oxygenation sampling based on brain imaging technology according to an embodiment of this application. The method includes at least the following steps:

[0038] 101. Select a light source / detector probe sleeve with a diameter ≤ 1.5cm.

[0039] First, a light source / detector probe sleeve with a diameter ≤1.5cm, which is different from the current ones, is selected and installed on the headgear worn by the tester. The light source / detector probe sleeve with a diameter ≤1.5cm is common knowledge, so this application will not explain its structure in detail.

[0040] Optionally, a light source / detector probe sleeve with a diameter ≤1.5cm can be threaded onto the head cap for easy installation and removal by the user.

[0041] 102. Geometrically, the light source / detector probes are arranged in pairs adjacent to each other, with each pair of light source probes and each pair of detector probes staggered.

[0042] To achieve high-density detection, this application proposes two high-density probe layout schemes, which incorporate geometric dimensions in both horizontal and vertical dimensions, so that each pair of light source / detector probes is adjacent to each other, and each pair of light source probes is staggered with each pair of detector probes.

[0043] Figure 5This application presents a high-density probe layout in the vertical dimension. Each number in the figure represents a test channel. The probes are arranged in several diagonal columns, with the overall probes distributed in a diamond shape. Each diagonal column is arranged in alternating pairs of light source / detector probes along the vertical direction. The distance between any two adjacent probes in any diagonal column is 1.5 cm, and the distance between the light source probe and its corresponding detector probe in any two adjacent diagonal columns is 3 cm. Compared with the traditional probe layout, more light source / detector probes can be arranged in the same area to achieve a high-density layout, thereby improving the spatial resolution of the test channel of near-infrared spectral imaging technology.

[0044] Optional, with Figure 5 Taking a certain light source probe point as an example, the arrow points to the detector probe point that it works with. In practice, the light source probe emits near-infrared light to the detector probe at a distance of 3cm and forms several test channels.

[0045] Figure 6 This application presents a high-density probe layout implemented in the horizontal dimension. Each number in the figure represents a test channel. The probes are arranged in several rows, forming a matrix distribution. Each row is arranged horizontally with two light source / detector probes alternating. The distance between any two adjacent probes in any row is 1.5 cm, and the distance between the light source probe and its corresponding detector probe in any two adjacent rows is 3 cm. Compared with the traditional probe layout, this method can arrange more light source / detector probes in the same area to achieve a high-density layout, thereby improving the spatial resolution of the test channel for near-infrared spectral imaging technology.

[0046] Optional, with Figure 6 Taking a certain light source probe point as an example, the arrow points to the detector probe point that it works with. In practice, the light source probe emits near-infrared light to the detector probe at a distance of 3cm and forms several test channels.

[0047] Optionally, the distance between the light source probe and the detector probe is not limited to 1.5cm, but can be further increased according to the intensity of the light source power to achieve an equal probe distance of 1.5cm or more, and the probes can be arranged according to the method described above.

[0048] In summary, this application, while maintaining a 3cm spacing between the light source probe and the detector probe, does not affect the detection depth of the light source / detector probe or its ability to detect scalp blood oxygenation information, thus ensuring signal quality as much as possible. On one hand, it achieves higher spatial resolution blood oxygenation detection, which is beneficial for obtaining more brain blood oxygenation information; on the other hand, it ensures the uniformity of probe spacing within the same horizontal or diagonal column, with a spacing of 1.5cm for all probes. The layout of this application can be rearranged horizontally or vertically, depending on the number of light source / detector probe pairs and actual application requirements. Neither the number of probe pairs nor the arrangement angle of the two high-density probe layouts in this application are fixed.

[0049] This application employs a clever design to ensure a 3cm spacing between each pair of light source / detector probes, thereby improving the spatial resolution of the detection channel. It also offers greater adaptability, allowing for layout modifications to accommodate advancements in light source technology and make it suitable for a wider range of probe detection scenarios.

[0050] This application also discloses a headgear for applying the above-mentioned probe layout method for high-density blood oxygenation sampling based on brain imaging technology.

[0051] Figure 7 This is a block diagram of an electronic device provided in one embodiment of this application. The device includes at least a processor 401 and a memory 402.

[0052] Processor 401 may include one or more processing cores, such as a quad-core processor or an octa-core processor. Processor 401 may be implemented using at least one hardware form selected from DSP (Digital Signal Processing), FPGA (Field-Programmable Gate Array), and PLA (Programmable Logic Array). Processor 401 may also include a main processor and a coprocessor. The main processor, also known as a CPU (Central Processing Unit), is used to process data in the wake-up state; the coprocessor is a low-power processor used to process data in the standby state. In some embodiments, processor 401 may integrate a GPU (Graphics Processing Unit), which is responsible for rendering and drawing the content to be displayed on the screen. In some embodiments, processor 401 may also include an AI (Artificial Intelligence) processor, which is used to handle computational operations related to machine learning.

[0053] The memory 402 may include one or more computer-readable storage media, which may be non-transitory. The memory 402 may also include high-speed random access memory and non-volatile memory, such as one or more disk storage devices or flash memory devices. In some embodiments, the non-transitory computer-readable storage media in the memory 402 are used to store at least one instruction, which is executed by the processor 401 to implement the probe layout method for high-density blood oxygenation sampling based on brain imaging technology provided in the method embodiments of this application.

[0054] In some embodiments, the electronic device may also optionally include: a peripheral device interface and at least one peripheral device. The processor 401, memory 402, and peripheral device interface can be connected via a bus or signal line. Each peripheral device can be connected to the peripheral device interface via a bus, signal line, or circuit board. Indicatively, peripheral devices include, but are not limited to: radio frequency circuitry, a touch display screen, audio circuitry, and a power supply.

[0055] Of course, electronic devices may also include fewer or more components, and this embodiment does not limit this.

[0056] Optionally, this application also provides a computer-readable storage medium storing a program that is loaded and executed by a processor to implement the probe layout method for high-density blood oxygenation sampling based on brain imaging technology in the above-described method embodiments.

[0057] Optionally, this application also provides a computer product including a computer-readable storage medium storing a program, which is loaded and executed by a processor to implement the probe layout method for high-density blood oxygenation sampling based on brain imaging technology described in the above method embodiments.

[0058] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0059] The above embodiments merely illustrate several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

Claims

1. A probe layout method for high-density blood oxygenation sampling based on brain imaging technology, characterized in that, The method includes: Select light source probe sleeves and detector probe sleeves with a diameter ≤ 1.5cm; Geometrically, the light source probes and detector probes are arranged in pairs adjacent to each other, with each pair of light source probes and each pair of detector probes staggered, including: In the vertical dimension, the light source probes and detector probes are arranged in several diagonal columns, and the probes are distributed in a diamond shape. Each diagonal column is arranged with two light source probes and two detector probes alternating along the vertical direction. The distance between any two adjacent probes in any diagonal column is 1.5cm, and the distance between the light source probe and its corresponding detector probe in any two adjacent diagonal columns is 3cm. The light source probe emits near-infrared light to the detector probe 3cm away and forms several test channels. More light source probes and detector probes are arranged in the same area to achieve a high-density layout. Alternatively, in the horizontal dimension, the light source probes and detector probes are arranged in several rows, with the probes distributed in a matrix. In each row, two light source probes and two detector probes are alternately distributed along the horizontal direction. The distance between any two adjacent probes in any row is 1.5 cm, and the distance between the light source probe and its corresponding detector probe in any two adjacent rows is 3 cm. The light source probe emits near-infrared light to the detector probe 3 cm away and forms several test channels. More light source probes and detector probes can be arranged in the same area to achieve a high-density layout.

2. The probe layout method for high-density blood oxygenation sampling based on brain imaging technology according to claim 1, characterized in that, The distance between the light source probe and the detector probe can be adjusted according to the intensity of the light source power, and the adjustment range of the probe distance is ≥1.5cm.

3. The probe layout method for high-density blood oxygenation sampling based on brain imaging technology according to claim 1, characterized in that, The light source probe sleeve and detector probe sleeve with a diameter ≤1.5cm can be installed on the head cap by means of threads.

4. A headgear for applying a probe layout method for high-density blood oxygenation sampling based on brain imaging technology as described in any one of claims 1 to 3.

5. An electronic device, characterized in that, The device includes a processor and a memory; the memory stores a program, which is loaded and executed by the processor to implement a probe layout method for high-density blood oxygenation sampling based on brain imaging technology as described in any one of claims 1 to 3.

6. A computer-readable storage medium, characterized in that, The storage medium stores a program that, when executed by a processor, is used to implement a probe layout method for high-density blood oxygenation sampling based on brain imaging technology as described in any one of claims 1 to 3.

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