A soothing / anti-sensitivity composition, its preparation method and application

Abstract

The present invention provides a soothing / anti-sensitivity composition, comprising raw materials in the following parts by weight: 9-20 parts of dendrobium nobile extract; 5-15 parts of tropaeolum majus extract; 5-15 parts of calendula officinalis extract; 1-3 parts of anthyllis vulneraria extract; 0.1-0.5 part of mirabilis jalapa extract. By applying the formula theory of "sovereign, minister, assistant and guide" in traditional Chinese medicine, the plant extracts are reasonably combined, and the components synergistically enhance each other, so as to effectively inhibit the skin inflammatory reaction, thereby achieving the effects of soothing and anti-inflammatory, repairing damaged skin. At the same time, by inhibiting the TRPV1 (transient receptor potential cation channel 1) signal transduction, the expression of pro-inflammatory factors such as IL-6, IL-8, and PGE2 is reduced, thereby reducing the over-sensitive state of the epidermis, and applying it to cosmetic products.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a soothing / anti-sensitivity composition, a preparation method thereof, and an application thereof. Background Art

[0002] Due to the growth of the population with sensitive skin, soothing products have received extensive attention from consumers. Therefore, more and more soothing and anti-sensitivity active ingredients and compositions have been developed and applied to products. Since the mechanism causing skin sensitivity is relatively complex and not fully verified, most of the soothing ingredients on the market are mainly chemical substances, and some even add hormone components.

[0003] The prior art CN112773738A discloses a moisturizing and soothing composition, which improves the water retention ability of the skin by combining oils and polyols, thereby reducing skin sensitivity problems caused by skin dryness. However, most of the substances used therein are chemically synthesized, and the soothing effect is not obvious, and it does not effectively target inflammation-related targets. CN110101651A discloses a soothing and repairing essence containing lysate of Saccharomyces boulardii fermentation product and a preparation method thereof. Its cost is relatively high, and due to different Saccharomyces boulardii strains and different fermentation processes, the efficacy and quality of its fermentation products vary greatly, and even may cause safety problems.

[0004] Therefore, it is very necessary to develop a plant-derived composition with anti-sensitivity efficacy and apply it to cosmetic products. Summary of the Invention

[0005] In view of this, the technical problem to be solved by the present invention is to provide a composition, and the composition provided by the present invention has soothing and anti-sensitivity effects.

[0006] The present invention provides a soothing / anti-sensitivity composition, comprising the following raw materials in parts by weight:

[0007]

[0008] The present invention creatively combines the above-mentioned extracts of Dendrobium nobile Lindl., Tropaeolum majus L., Calendula officinalis L., Anthyllis vulneraria L., and Mirabilis jalapa L. to give full play to their respective advantages, and finally forms a soothing / anti-sensitivity product.

[0009] Preferably, it comprises the following raw materials in parts by weight:

[0010]

[0011] Under the above appropriate ratio, through the compounding of the above components, reasonably matching plant extracts, and the components cooperate with each other, it can effectively inhibit the skin inflammatory reaction, thereby achieving the effects of soothing and anti-inflammation, and repairing damaged skin.

[0012] Preferably, it comprises raw materials in the following parts by weight:

[0013]

[0014] Under the above optimal ratio, the above components of the present invention cooperate with each other, and have good soothing and anti-sensitivity effects.

[0015] Preferably, it further comprises:

[0016] 60 - 70 parts of a humectant;

[0017] 0.5 - 1.5 parts of a preservative.

[0018] Under the condition of adding the above humectant and preservative, cooperating with the remaining components, better moisturizing and anti-corrosion effects can be achieved.

[0019] Preferably, the humectant includes one or more of water, glycerol, propylene glycol or butylene glycol;

[0020] The preservative is one or more of phenoxyethanol, ethylhexylglycerin or p-hydroxyacetophenone.

[0021] The present invention provides a method for preparing the soothing / anti-sensitivity composition according to any one of the above technical solutions, comprising the following steps:

[0022] Take the extracts of Dendrobium nobile Lindl., Tropaeolum majus L., Calendula officinalis L., Anthyllis vulneraria L. and Mirabilis jalapa L. and mix them to obtain.

[0023] Preferably, the mixing is stirring mixing, the temperature of stirring is 20 - 30 °C; the rotation speed of the stirring is 500 rpm.

[0024] The above specific mixing method of the present invention makes the particles of the prepared composition more uniform, with a better skin feel and better skin affinity.

[0025] The present invention provides the application of the composition according to any one of the above in the preparation of anti-sensitivity cosmetic products.

[0026] The present invention provides a soothing / anti-sensitivity cosmetic product, comprising the composition according to any one of the above technical solutions.

[0027] Preferably, the product is a liquid foundation, loose powder or powder cake.

[0028] Compared with the prior art, the present invention provides a soothing / anti-sensitivity composition, comprising the following raw materials in parts by weight: 9-20 parts of Dendrobium nobile Lindl. extract; 5-15 parts of Tropaeolum majus L. extract; 5-15 parts of Calendula officinalis L. extract; 0.8-3 parts of Anthyllis vulneraria L. extract; 0.1-0.5 part of Mirabilis jalapa L. extract. By applying the traditional Chinese medicine formula theory of "sovereign, minister, assistant, and guide", the plant extracts are reasonably combined, and the components synergistically enhance each other's effects, can effectively inhibit the skin inflammatory reaction so as to achieve the effects of soothing and anti-inflammatory, repair damaged skin, and at the same time, by inhibiting the TRPV1 (transient receptor potential cation channel 1) signal transduction, reduce the expression of pro-inflammatory factors such as IL-6, IL-8, PGE2, etc., thereby reducing the epidermal hypersensitivity state, and applying it to cosmetic products. Detailed implementation manners

[0029] The present invention provides a soothing composition, its preparation method and application. Those skilled in the art can draw on the content of this article and appropriately improve the process parameters to achieve. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art, and they all belong to the protection scope of the present invention. The methods and applications of the present invention have been described through preferred embodiments. Relevant personnel can obviously make changes or appropriate alterations and combinations to the methods and applications in this article without departing from the content, spirit and scope of the present invention to implement and apply the technology of the present invention.

[0030] The present invention provides a soothing / anti-sensitivity composition, comprising the following raw materials in parts by weight:

[0031]

[0032] When the total amount is 100, the above parts by weight are equivalent to weight percentages.

[0033] The soothing composition provided by the present invention comprises 9-20 parts by weight of Dendrobium nobile Lindl. extract; preferably comprises 9-18 parts by weight of Dendrobium nobile Lindl. extract; more preferably comprises 12-16 parts by weight of Dendrobium nobile Lindl. extract.

[0034] Based on the formula idea of "sovereign, minister, assistant, and guide" in traditional Chinese medicine, the inventor of the present invention uses the extract of Dendrobium nobile Lindl. flower as the "sovereign drug", which contains anthocyanins, can activate the antioxidant enzyme system, effectively scavenge free radicals, have antioxidant and anti-inflammatory effects at the same time.

[0035] The soothing composition provided by the present invention comprises 5-15 parts by weight of Tropaeolum majus L. extract; preferably comprises 6-13 parts by weight of Tropaeolum majus L. extract; more preferably comprises 8-11 parts by weight of Tropaeolum majus L. extract.

[0036] In the present invention, the extracts of Trollius chinensis and Anthyllis vulneraria are the "ministerial herbs", which contain components such as flavonoids, alkaloids, and organic acids, have the effects of inhibiting bacteria and suppressing the expression of inflammatory factors, and resist inflammation in multiple dimensions.

[0037] The soothing composition provided by the present invention comprises 5-15 parts by weight of calendula extract; preferably, it comprises 6-13 parts by weight of calendula extract; more preferably, it comprises 7-12 parts by weight of calendula extract.

[0038] In the present invention, the calendula extract is the "adjuvant herb", which is rich in vitamin A and vitamin C, can inhibit pigmentation and delay aging, and can assist in improving local skin dullness, uneven skin color and other problems caused by inflammation.

[0039] The soothing composition provided by the present invention comprises 0.8-3 parts by weight of Anthyllis vulneraria extract; it can specifically be 0.8 part by weight, 1 part by weight, 2 parts by weight or 3 parts by weight, or a point value between the above two.

[0040] The soothing composition provided by the present invention comprises 0.1-0.5 parts by weight of Mirabilis jalapa extract; preferably, it comprises 0.1-0.4 parts by weight of Mirabilis jalapa extract; more preferably, it comprises 0.1-0.3 parts by weight of Mirabilis jalapa extract.

[0041] Among them, the Mirabilis jalapa extract is the "conducting herb", which acts on TRPV1, regulates the discomfort transmission factor, reduces the over-sensitive state of the epidermis, and can also act on TRPV4 to restore the skin barrier function, and repair and prevent skin problems caused by external stimuli on the basis of soothing.

[0042] In some embodiments of the present invention, the soothing composition provided by the present invention further comprises 60-70 parts by weight of a humectant; preferably, it comprises 62-68 parts by weight of a humectant; most preferably, it comprises 63-67 parts by weight of a humectant.

[0043] The humectant described in the present invention comprises one or several of water, glycerol, propylene glycol or butanediol.

[0044] In some embodiments of the present invention, the soothing composition provided by the present invention further comprises 0.5-1.5 parts by weight of a preservative; preferably, it comprises 0.6-1.3 parts by weight of a preservative; most preferably, it comprises 0.7-1.2 parts by weight of a preservative.

[0045] The preservative is one or several of phenoxyethanol, ethylhexylglycerin or p-hydroxyacetophenone.

[0046] In some preferred embodiments of the present invention, a soothing / anti-sensitivity composition provided by the present invention comprises raw materials in the following parts by weight:

[0047]

[0048] In some preferred embodiments of the present invention, a soothing / anti-sensitivity composition provided by the present invention comprises raw materials in the following parts by weight:

[0049]

[0050] In some preferred embodiments of the present invention, a soothing / anti-sensitivity composition provided by the present invention comprises raw materials in the following parts by weight:

[0051]

[0052] In some preferred embodiments of the present invention, a soothing / anti-sensitivity composition provided by the present invention comprises raw materials in the following parts by weight:

[0053]

[0054] The present invention innovatively introduces Dendrobium nobile Lindl. extract and Anthyllis vulneraria L. extract and applies them to the soothing composition. The Dendrobium nobile Lindl. flower extract is rich in anthocyanins and has excellent effects such as scavenging free radicals, antioxidant, anti-inflammatory, and lipid-lowering, and can effectively inhibit the irritation brought to the skin by external reactive oxygen species; while the Anthyllis vulneraria L. extract contains flavonoid rutin, which has anti-inflammatory and antioxidant effects on the skin, can promote wound healing, anti-inflammatory, sedative and repair the skin barrier.

[0055] The present invention creatively combines the above-mentioned Dendrobium nobile Lindl. extract, Tropaeolum majus L. extract, Calendula officinalis L. extract, Anthyllis vulneraria L. extract and Mirabilis jalapa L. extract to play their respective advantages and finally form a soothing / anti-sensitivity product.

[0056] The present invention provides a preparation method of the soothing / anti-sensitivity composition according to any one of the above technical solutions, comprising the following steps:

[0057] Mix the Dendrobium nobile Lindl. extract, Tropaeolum majus L. extract, Calendula officinalis L. extract, Anthyllis vulneraria L. extract and Mirabilis jalapa L. extract to obtain the product.

[0058] The present invention has clearly described the specific ratios of the above components and will not be elaborated herein.

[0059] Mix the Dendrobium nobile Lindl. extract, Tropaeolum majus L. extract, Calendula officinalis L. extract, Anthyllis vulneraria L. extract and Mirabilis jalapa L. extract; the present invention does not limit the above mixing method, and those well-known to those skilled in the art can be used. Preferably, the mixing is stirring mixing, and more preferably magnetic stirrer mixing. The temperature of stirring is preferably 20-30 °C; the rotation speed of the stirring is preferably 500 rpm.

[0060] In some preferred embodiments of the present invention, in the presence of a humectant and a preservative:

[0061] Mix the extract of Dendrobium nobile Lindl., the extract of Tropaeolum majus L., the extract of Calendula officinalis L., the extract of Anthyllis vulneraria L., the extract of Mirabilis jalapa L., the humectant and the preservative; the present invention does not limit the above mixing method, and any method well known to those skilled in the art can be used. Preferably, the mixing is stirring mixing, and more preferably magnetic stirrer mixing. The temperature of stirring is preferably 20 - 30°C; the rotation speed of the stirring is preferably 500 rpm.

[0062] The present invention provides the application of the composition according to any one of the above in the preparation of an anti-sensitivity cosmetic product.

[0063] The present invention provides a soothing / anti-sensitivity cosmetic product, comprising the composition according to any one of the above technical solutions.

[0064] The base makeup product of the present invention is liquid foundation, loose powder or powder cake.

[0065] The above product of the present invention further comprises common ingredients in the cosmetic field, and the present invention does not limit this.

[0066] When the soothing composition of the present invention is applied in a base makeup product, compared with commercially available products, it has the effects of good soothing and safety.

[0067] The present invention provides a soothing / anti-sensitivity composition, comprising the following raw materials in parts by weight: 9 - 20 parts of extract of Dendrobium nobile Lindl.; 5 - 15 parts of extract of Tropaeolum majus L.; 5 - 15 parts of extract of Calendula officinalis L.; 0.8 - 3 parts of extract of Anthyllis vulneraria L.; 0.1 - 0.5 parts of extract of Mirabilis jalapa L. By applying the traditional Chinese medicine "monarch, minister, assistant, and guide" formula theory, the present invention rationally combines plant extracts, and the components cooperate with each other, which can effectively inhibit the skin inflammatory reaction, thereby achieving the effect of soothing and anti-inflammatory, repairing damaged skin. At the same time, by inhibiting the TRPV1 (transient receptor potential cation channel 1) signal transduction, the expression of pro-inflammatory factors such as IL-6, IL-8, and PGE2 is reduced, thereby reducing the over-sensitive state of the epidermis, and applying it to cosmetic products.

[0068] In order to further illustrate the present invention, the following examples are used to describe in detail a soothing composition, its preparation method and application provided by the present invention.

[0069] Examples 1 - 4, Comparative Examples 1 - 3

[0070] Table 1

[0071]

[0072] Preparation method:

[0073] Weigh the extracts of Dendrobium nobile Lindl., Trollius chinensis Bunge, Calendula officinalis L., Anthyllis vulneraria L., and Mirabilis jalapa L. respectively according to the above mass ratio, and use a magnetic stirrer to set the rotation speed at 500 rpm and stir and mix evenly at room temperature.

[0074] Test method:

[0075] Use the zebrafish soothing efficacy test method to test the soothing and anti-sensitivity efficacy of the examples and comparative examples.

[0076] Test principle:

[0077] Sodium lauryl sulfate (SLS) may cause a stimulatory reaction in the body after acting on the body. The stimulant enters the zebrafish body, induces an inflammatory response, and neutrophils undergo an immune response, migrating and aggregating towards the skin epidermis. The change in the number of skin neutrophils in transgenic neutrophil green fluorescent strain zebrafish (MPX) before and after treatment is used to detect whether the sample has a soothing effect.

[0078] Test steps:

[0079] Randomly select zebrafish into 6-well plates, 15 tails per well.

[0080] Establish a zebrafish skin inflammation model by administering SLS in water solution.

[0081] Administer the sample in water solution, and at the same time set up a normal control group and a model control group, with a volume of 3 mL per well.

[0082] Incubate in the dark at 28 °C for 18 h.

[0083] Randomly select 10 zebrafish from each experimental group and place them under a fluorescence microscope for photographing. Use advanced image processing software to analyze and collect data, analyze the number of skin neutrophils (N) in zebrafish, and calculate the soothing efficacy of the sample according to the formula to judge whether it has a soothing effect.

[0084]

[0085]

[0086] Test results:

[0087] In Examples 1-3, by increasing or decreasing different components in the composition and changing the addition amounts, the soothing efficacy also changes accordingly. After adding the extract of Coronilla varia and the extract of Mirabilis jalapa in Example 1 compared with Comparative Example 5, the soothing efficacy increased significantly; in Example 3, when the extract of Coronilla varia decreased, the soothing efficacy decreased slightly; in Example 2, when the addition amounts of the extracts of Dendrobium nobile, Tropaeolum majus, and Calendula officinalis decreased, the soothing ability became worse. Compared with Example 1, Comparative Example 1 added asiaticoside and used the extracts of Matricaria recutita and Portulaca oleracea to replace the extracts of Coronilla varia and Mirabilis jalapa, and its soothing ability decreased significantly. In addition, the raw material price of asiaticoside is relatively high, and the requirements for purity and extraction process are relatively high.

[0088] Compared with Example 1, Comparative Example 2 added asiaticoside and the extract of Gentiana macrophylla and reduced the addition of the extract of Coronilla varia, and the soothing ability decreased significantly.

[0089] From the results of Comparative Example 1 and Comparative Example 2, it can be seen that the extract of Coronilla varia has good soothing ability, but there is no significant synergistic effect with other components.

[0090] Compared with Comparative Example 5, Comparative Example 3 added the extract of aescin and the extract of roots of Ruscus aculeatus, and its soothing efficacy decreased.

[0091] In Comparative Example 2 and Comparative Example 3, the detection concentration was 0.0025%, which was much lower than 0.5% in Examples 1-4 and Comparative Example 5, indicating that the cytotoxicity of Comparative Example 2 and Comparative Example 3 was relatively large.

[0092] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A soothing / anti-sensitivity composition, characterized in that, Comprising the following raw materials in parts by weight:

2. The composition according to claim 1, wherein Further comprising: 60 - 70 parts of a humectant; 0.5 - 1.5 parts of a preservative.

3. The composition according to claim 2, wherein the humectant comprises one or more of water, glycerol, propylene glycol or butylene glycol; the preservative is one or more of phenoxyethanol, ethylhexylglycerin or p - hydroxyacetophenone.

4. A method for preparing the soothing / anti-sensitivity composition according to any one of claims 1 to 3, characterized in that, Comprising the following steps: Taking extracts of Dendrobium nobile Lindl., Trollius chinensis Bunge, Calendula officinalis L., Anthyllis vulneraria L., Mirabilis jalapa L., a humectant and a preservative and mixing them to obtain the product.

5. The preparation method according to claim 4, characterized in that, The mixing is stirring, and the temperature of stirring is 20 - 30°C; the rotation speed of the stirring is 500 rpm.

6. Use of the composition according to any one of claims 1 - 3 in the preparation of an anti - sensitive cosmetic product.

7. A soothing / anti-sensitivity cosmetic product, characterized in that, Comprising the composition according to any one of claims 1 - 3.

8. The product according to claim 7, wherein The product is a liquid foundation, loose powder or powder cake.

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