Filling system and filling method

Abstract

The present disclosure provides a filling system and a filling method, the filling system comprising: a first filling assembly and a second filling assembly, the first filling assembly comprising a liquid inlet needle and a first liquid outlet needle; the second filling assembly comprising a liquid storage tank and a second liquid outlet needle, the liquid storage tank being provided with a first interface adapted to be connected with the first liquid outlet needle, wherein the first liquid outlet needle is configured to have a first working state separated from the first interface and a second working state connected with the first interface; when the first liquid outlet needle is in the first working state, the first filling assembly and the second filling assembly are configured to respectively deliver fluid into a preparation bottle by using the first liquid outlet needle and the second liquid outlet needle; when the first liquid outlet needle is in the second working state, the first filling assembly and the second filling assembly are configured to be in an assembled state, and fluid is delivered into the preparation bottle by using the second liquid outlet needle.

Description

TECHNICAL FIELD

[0001] The present disclosure relates to the technical field of medical devices, and in particular, to a filling system and a filling method. BACKGROUND

[0002] Radioactive liquid medicine has strong radiation, and production needs to be operated in a shielding isolation box. Usually, the dilution and filling of the liquid medicine need to be automated. Therefore, a radioactive liquid medicine storage container and a pipeline connected with the filling pump are needed to pump the liquid medicine to the preparation bottle.

[0003] The effective period of radioactive liquid medicine is usually short, ranging from a few hours to tens of days. Different radionuclides of radioactive liquid medicine have different half-lives. Before the liquid medicine is produced to the clinical use, the activity of the radioactive liquid medicine continuously decreases due to the half-life of the radionuclide. Therefore, during the production of the radioactive liquid medicine, the liquid medicine with a specific activity is usually filled according to the clinical needs, so as to provide a liquid medicine preparation with sufficient radioactive activity at the time of clinical administration. How to control the radioactive activity of each bottle of liquid medicine preparation at the time of filling is a key technology in the production of radioactive liquid medicine. SUMMARY

[0004] The purpose of the present disclosure is to provide a filling system and a filling method to solve the technical problems in the related art. The specific solutions are as follows:

[0005] According to a first aspect of an embodiment of the present disclosure, a filling system is provided, comprising: a first filling assembly, the first filling assembly comprising a liquid inlet needle and a first liquid outlet needle; a second filling assembly, the second filling assembly comprising a liquid storage tank and a second liquid outlet needle, the liquid storage tank being provided with a first interface adapted to be connected with the first liquid outlet needle, wherein the first liquid outlet needle is configured to have a first working state separated from the first interface and a second working state connected with the first interface; when the first liquid outlet needle is in the first working state, the first filling assembly and the second filling assembly are configured to respectively transport fluid into a preparation bottle by using the first liquid outlet needle and the second liquid outlet needle; when the first liquid outlet needle is in the second working state, the first filling assembly and the second filling assembly are configured to be in an assembled state, and the fluid is transported into the preparation bottle by using the second liquid outlet needle.

[0006] In some embodiments, the first filling assembly further comprises: a first peristaltic pump, two ends of the first peristaltic pump being connected with the liquid inlet needle and the first liquid outlet needle respectively, the first peristaltic pump being configured to transport the fluid from the liquid inlet needle to the first liquid outlet needle.

[0007] In some embodiments, the liquid storage tank is provided with a second interface for filling the original liquid medicine, a third interface for installing an air filter element, and a liquid outlet for the fluid flowing out of the liquid storage tank.

[0008] In some embodiments, the second filling assembly further comprises a tee connector, a second peristaltic pump having two ends connected to the liquid outlet of the liquid storage tank and a first port of the tee connector respectively, and a hydrophobic filter membrane connected to a second port of the tee connector, and the second liquid outlet needle is connected to a third port of the tee connector; the second peristaltic pump is configured to have a third working state and a fourth working state, when the second peristaltic pump is in the third working state, the second peristaltic pump is configured to transport external gas to the liquid storage tank through the hydrophobic filter membrane so that the fluid in the liquid storage tank is uniformly bubbled under the action of the gas; when the second peristaltic pump is in the fourth working state, the second peristaltic pump is configured to make the fluid in the liquid storage tank flow to the second liquid outlet needle.

[0009] In some embodiments, a first one-way valve is arranged between the third port of the tee connector and the hydrophobic filter membrane, and a second one-way valve is arranged between the second port of the tee connector and the second liquid outlet needle, wherein the first one-way valve is configured to allow external air to flow from the hydrophobic filter membrane to the inside of the second filling assembly in one direction, and the second one-way valve is configured to allow fluid to flow from the liquid storage tank to the second liquid outlet needle in one direction.

[0010] In some embodiments, the first peristaltic pump and / or the second peristaltic pump comprises a pair of peristaltic pump tubes arranged in pairs so that the fluid is pumped along two branches.

[0011] According to a second aspect of the embodiments of the present disclosure, a filling method is provided, which adopts the filling system of any one of the first aspect of the present disclosure to dilute and mix the to-be-diluted fluid and obtain the standard fluid of a predetermined concentration; when the first liquid outlet needle is in the first working state, the filling system has a first filling method; when the first liquid outlet needle is in the second working state, the filling system has a second filling method.

[0012] In some embodiments, when the filling system uses the first filling method, the first liquid outlet needle is separated from the first interface; the first filling method comprises: using the first filling assembly to fill the dilution liquid into the preparation bottle located at the first station; and using the second filling assembly to fill the original drug liquid into the preparation bottle located at the second station.

[0013] In some embodiments, before using the second filling assembly to fill the original drug liquid into the preparation bottle located at the second station, the first filling method further comprises: transporting the original drug liquid into the liquid storage tank; and introducing gas into the liquid storage tank to make the original drug liquid in the liquid storage tank uniformly bubbled.

[0014] In some embodiments, when the filling system uses a second filling method, the first liquid outlet needle is in butt joint with the first interface, and the second filling method comprises: transmitting diluent into the liquid storage tank by using a first filling assembly to dilute the raw liquid in the liquid storage tank into diluted liquid; and filling the diluted liquid into the preparation bottle at the third station by using a second filling assembly.

[0015] In some embodiments, before the diluent is transmitted into the liquid storage tank by using the first filling assembly to dilute the raw liquid in the liquid storage tank into diluted liquid, the filling method further comprises: transmitting the raw liquid into the liquid storage tank.

[0016] In some embodiments, before the diluted liquid is filled into the preparation bottle at the third station by using the second filling assembly, the filling method further comprises: bubbling the diluted liquid in the liquid storage tank uniformly by introducing gas into the liquid storage tank.

[0017] Compared with the related art, the above scheme of the embodiments of the present disclosure has at least the following beneficial effects:

[0018] The filling system and the filling method provided by the present disclosure provide two different working states and filling methods, and realize two liquid filling processes of simultaneous filling and dilution and dilution first and then filling for the same filling system.

[0019] It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and cannot limit the present disclosure. BRIEF DESCRIPTION OF DRAWINGS

[0020] The accompanying drawings, which are incorporated into and form part of the specification, illustrate embodiments consistent with the present disclosure and, together with the specification, serve to explain the principles of the present disclosure. It is obvious that the drawings in the following description are only some embodiments of the present disclosure, and other drawings can be obtained by those skilled in the art without creative labor. In the drawings:

[0021] Figure 1 is an exploded structural view of a filling system according to an exemplary embodiment.

[0022] Figure 2 is a structural schematic view of a filling system when a first liquid outlet needle is in a first working state according to an exemplary embodiment.

[0023] Figure 3 is Figure 2 is a partial enlarged view of part A in

[0024] Figure 4is a structural schematic diagram of a filling system when a first liquid outlet needle is in a second working state according to an example embodiment.

[0025] Figure 5 is a structural schematic diagram of a filling system when a first liquid outlet needle is in a second working state according to another example embodiment.

[0026] Figure 6 is a structural schematic diagram of a filling system when a first liquid outlet needle is in a second working state according to another example embodiment.

[0027] Reference signs:

[0028] A first filling assembly 100, a liquid inlet needle 110, a first peristaltic pump 120, a first liquid outlet needle 130;

[0029] A second filling assembly 200, a liquid storage tank 210, a first interface 211, a second interface 212, a third interface 213, a liquid outlet 214, a second peristaltic pump 220, a peristaltic pump pipe 221, a silica gel pipe 222;

[0030] A three-way connector 230, a first one-way valve 231, a second one-way valve 232, a first port 2301, a second port 2302, a third port 2303;

[0031] A hydrophobic filter membrane 240, a second liquid outlet needle 250, an air filter element 260;

[0032] A diluent storage tank 310, an infusion bottle 320, a preparation bottle 330;

[0033] A first pipe clamp structure 410, a second pipe clamp structure 420;

[0034] A filling system 1000. DETAILED DESCRIPTION

[0035] In order to make the objectives, technical solutions and advantages of the present disclosure clearer, further detailed description will be made to the present disclosure with reference to the drawings, obviously, the described embodiments are only a part of the embodiments of the present disclosure, rather than all the embodiments. Based on the embodiments in the present disclosure, all other embodiments obtained by those skilled in the art without creative work, shall fall within the protection scope of the present disclosure.

[0036] The terms used in the embodiments of the present disclosure are merely for the purpose of describing specific embodiments, and are not intended to limit the present disclosure. The singular forms "a", "said" and "the" used in the embodiments of the present disclosure and the appended claims are also intended to include the plural forms, unless the context clearly indicates otherwise, "a plurality of" generally contains at least two, and other quantifiers are similar.

[0037] It should be understood that, although the terms first, second, third, etc. can be used herein to describe various …, these … should not be limited to these terms. These terms are only used to distinguish one … from another. For example, a first … could also be termed a second …, and, similarly, a second … could also be termed a first …, without departing from the scope of the embodiments of the present disclosure. Also, the terms "first", "second", "third", etc. are used herein for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0038] It should be understood that the term "and / or" used herein is only a description of the association relationship of the associated objects, which means that there can be three relationships, for example, A and / or B can represent: A exists alone, A and B exist together, and B exists alone. In addition, the character " / " herein generally represents that the front and rear associated objects are in an "or" relationship. The singular forms "a", "said" and "the" are also intended to include the plural forms, unless the context clearly indicates otherwise.

[0039] It should be further understood that the terms "center", "longitudinal", "transverse", "front", "back", "up", "down", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the embodiments and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.

[0040] In the description of the present disclosure, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected", "connected" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0041] Depending on the context, the word "if" as used herein can be interpreted to mean "when" or "while" or "in response to the determination" or "in response to the detection". Similarly, the phrase "if determined" or "if detecting (a stated condition or event)" can be interpreted to mean "when determined" or "in response to the determination" or "when detecting (a stated condition or event)" or "in response to the detection (a stated condition or event)", depending on the context.

[0042] It is also to be noted that the terms "comprising", "comprises" or any other variation thereof are intended to cover a non-exclusive inclusion, such that a product or process that comprises a list of elements does not include only those elements but can also include other elements not expressly listed or inherent to such product or process. An element proceeded by "comprises a" does not, without further constraints, exclude the presence of additional identical elements in the product or process that contains the referred element.

[0043] In the related art, due to the strong radiation of the radioactive liquid medicine, production needs to be operated in a shielding isolation box, and the dilution and filling of the liquid medicine usually need to be automatically performed. Therefore, a radioactive liquid medicine storage container and a pipeline connected with the filling pump and pumping the liquid medicine to the preparation bottle are needed.

[0044] The effective period of the radioactive liquid medicine is usually short, ranging from several hours to tens of days. Different radionuclides of the radioactive liquid medicine have different half-lives. Before the liquid medicine is produced to the clinical use, the activity of the radioactive liquid medicine continuously decreases due to the half-life of the radionuclide. Therefore, when producing the radioactive liquid medicine, it is usually necessary to fill the liquid medicine with a specific activity according to the clinical needs, so as to provide a liquid medicine preparation with sufficient radioactivity at the time of clinical administration. How to control the radioactivity of each bottle of liquid medicine preparation at the time of filling is a key technology for producing radioactive liquid medicine.

[0045] For the radioactive liquid medicine with a short half-life, the liquid medicine filling adopts a filling and dilution process, that is, the diluent and the original liquid medicine are filled into the preparation bottle respectively, and different activity concentrations of the liquid medicine preparation are obtained by adjusting the proportion of the diluent and the original liquid medicine, so as to obtain different radioactivity of the medicine under the condition of fixed volume of the liquid medicine.

[0046] For the radioactive liquid medicine with a long half-life of radionuclide, the liquid medicine filling adopts a dilution and filling process, that is, the diluent and the original liquid medicine are mixed uniformly, and then the diluted liquid medicine is filled into the preparation bottle according to different volumes, so as to obtain liquid medicine preparations with different radioactivity.

[0047] In the related art, due to the different half-life periods of the radioactive liquid medicine, the filling methods of the liquid medicine are also different. Therefore, two filling systems need to be used to meet different filling requirements according to the filling characteristics, which has a complex structure and high production cost and time cost in the filling process.

[0048] In view of the technical problems in the related art, the present disclosure provides a filling system 1000 and a filling method, which can be compatible with both the filling and dilution process and the dilution and filling process through different combination methods, including the combination methods thereof under different filling methods, and the way of diluting and mixing the radioactive liquid medicine.

[0049] Optional embodiments of the present disclosure will be described in detail below with reference to the accompanying drawings.

[0050] Figure 1 is an exploded structural diagram of a filling system according to an exemplary embodiment. Figure 2 is a structural diagram of a filling system when a first liquid outlet needle is in a first working state according to an exemplary embodiment. Figure 3 is Figure 2 is a partial enlarged view of part A in FIG. 4. Figure 4 is a structural diagram of a filling system when a first liquid outlet needle is in a second working state according to an exemplary embodiment. Figure 5 is a structural diagram of a filling system when a first liquid outlet needle is in a second working state according to another exemplary embodiment. Figure 6 is a structural diagram of a filling system when a first liquid outlet needle is in a second working state according to another exemplary embodiment.

[0051] According to a first aspect of embodiments of the present disclosure, a filling system 1000 is provided, which includes a first filling assembly 100 and a second filling assembly 200.

[0052] As shown in FIG. 1, the first filling assembly 100 includes a liquid inlet needle 110 and a first liquid outlet needle 130, and the second filling assembly 200 includes a liquid storage tank 210 and a second liquid outlet needle 250. Figure 1

[0053] A first interface 211 adapted for connection of the first liquid outlet needle 130 is arranged on the liquid storage tank 210. As shown in FIG. 2, the first liquid outlet needle 130 is configured to have a first working state separated from the first interface 211 and a second working state connected to the first interface 211. Figure 2 Figure 4

[0054] As shown in FIG. 3, when the first liquid outlet needle 130 is in the first working state, the first filling assembly 100 and the second filling assembly 200 are configured to respectively deliver fluid into a preparation bottle 330 by using the first liquid outlet needle 130 and the second liquid outlet needle 250. Figure 2 For example, the first liquid outlet needle 130 of the first filling assembly 100 is connected to a diluent storage tank 310, and the first liquid outlet needle 130 is used to deliver diluent into the preparation bottle 330. The second filling assembly 200 is connected to a radioactive stock solution infusion bottle 320, and the second liquid outlet needle 250 is used to deliver radioactive stock solution into the preparation bottle 330.

[0055] As shown in FIG. 4, when the first liquid outlet needle 130 is in the second working state, the first filling assembly 100 and the second filling assembly 200 are configured to respectively deliver fluid into the preparation bottle 330 by using the first liquid outlet needle 130 and the second liquid outlet needle 250.

[0056] Figure 4 ​​​​As shown, when the first liquid outlet needle 130 is in the second working state, the first filling assembly 100 and the second filling assembly 200 are configured in an assembled state, and the second liquid outlet needle 250 is used to deliver fluid into the preparation bottle 330, for example, the first filling assembly 100 uses the first liquid outlet needle 130 to inject diluent into the liquid storage tank 210 of the second filling assembly 200, dilute the radioactive stock solution in the dilution liquid storage tank 210 to form a radioactive drug solution, and then the second liquid outlet needle 250 is used to deliver the radioactive drug solution into the preparation bottle 330.

[0057] It should be noted that the stock solution can be a radioactive stock solution, which is mixed with diluent to form a radioactive drug solution.

[0058] In some embodiments, the preparation bottle 330 is configured to be switched between a first station and a second station to receive fluid delivered by the first liquid outlet needle 130 or the second liquid outlet needle 250.

[0059] It should be noted that the preparation bottle 330 is a fluid-carrying container and is not included in the filling system 1000 of the present disclosure.

[0060] In some embodiments, the first filling assembly 100 further comprises a first peristaltic pump 120, two ends of the first peristaltic pump 120 are respectively connected with the liquid inlet needle 110 and the first liquid outlet needle 130, and the first peristaltic pump 120 is configured to deliver fluid from the liquid inlet needle 110 to the first liquid outlet needle 130.

[0061] As shown, the first peristaltic pump 120 can adjust the filling ratio of the diluent according to the needs of filling a specific activity drug solution. Figure 2

[0062] Specifically, the first peristaltic pump 120 is connected with the liquid inlet needle 110 and the first liquid outlet needle 130 through a peristaltic pump pipe 221, fluid can enter the peristaltic pump pipe 221 from the liquid inlet needle 110, and under the action of the first peristaltic pump 120, the fluid is delivered from the liquid inlet needle 110 to the first liquid outlet needle 130 at a certain ratio, and finally the fluid is delivered into the preparation bottle 330 through the first liquid outlet needle 130.

[0063] In some embodiments, the fluid in the first filling assembly 100 can be configured as diluent.

[0064] Specifically, the liquid inlet needle 110 is connected with the diluent storage tank 310, and under the action of the first peristaltic pump 120, the diluent can be pumped into the peristaltic pump pipe 221 from the liquid inlet needle 110 at a certain ratio, and then delivered into the preparation bottle 330 by the first liquid outlet needle 130.

[0065] In some embodiments, as shown in Figure 1 ,​Figure 2 As shown, the liquid storage tank 210 is provided with a second interface 212 for filling radioactive stock solution, a third interface 213 for installing an air filter 260, and a liquid outlet 214 for fluid flow out of the liquid storage tank 210.

[0066] The second interface 212 of the liquid storage tank 210 is connected with the infusion bottle 320 for filling radioactive stock solution, and the liquid outlet 214 is used to guide the fluid inside the liquid storage tank 210 out of the liquid storage tank 210.

[0067] The third interface 213 can be used to install the air filter 260 to adjust the air pressure balance between the inside of the liquid storage tank 210 and the outside, assist the smooth filling of the radioactive stock solution into the liquid storage tank 210 from the second interface 212, and avoid impurities in the air entering the liquid storage tank 210.

[0068] In some embodiments, the second filling assembly 200 further comprises a tee connector 230, a second peristaltic pump 220, and a hydrophobic filter membrane 240.

[0069] As shown in Figure 2 , Figure 3 The two ends of the second peristaltic pump 220 are respectively connected with the liquid outlet 214 of the liquid storage tank 210 and the first port 2301 of the tee connector 230, and the fluid in the liquid storage tank 210 can flow from the liquid storage tank 210 to the first port 2301 of the tee connector 230.

[0070] The hydrophobic filter membrane 240 is connected with the second port 2302 of the tee connector 230, and the second liquid outlet needle 250 is connected with the third port 2303 of the tee connector 230.

[0071] Specifically, the fluid flowing from the inside of the liquid storage tank 210 to the first port 2301 of the tee connector 230 can flow into the preparation bottle 330 through the second liquid outlet needle 250, and the outside air can flow into the second filling assembly 200 through the hydrophobic filter membrane 240 via the second port 2302 of the tee connector 230.

[0072] The hydrophobic filter membrane 240 has the function of isolating liquid, and when the inside and outside air passes through the hydrophobic filter membrane 240, the water vapor flow between the inside and outside of the filling system 1000 can be isolated.

[0073] In other embodiments, the second port 2302 of the tee connector 230 is connected with the third interface 213 of the liquid storage tank 210 through the hydrophobic filter membrane 240.

[0074] As shown in Figure 5 The third interface 213 of the liquid storage tank 210 is connected with the second port 2302 of the tee connector 230 to form a closed loop.

[0075] Specifically, when the radioactive stock solution is filled by the second interface 212 of the liquid storage tank 210, the air inside the liquid storage tank 210 will be transmitted to the hydrophobic filter membrane 240 along the silica gel tube 222 through the third interface 213 of the liquid storage tank 210. The air can move along the silica gel tube 222 under the action of the second peristaltic pump 220, enter the inside of the liquid storage tank 210 after passing through the three-way connector 230, so as to make the radioactive stock solution or radioactive solution inside the liquid storage tank 210 bubble uniformly.

[0076] It should be noted that, due to the isolation of water vapor by the setting of the hydrophobic filter membrane 240, the liquid entrained in the gas transported along the silica gel tube 222 inside the liquid storage tank 210 will not pass through the hydrophobic filter membrane 240, and the radioactive stock solution or radioactive solution passing through the second peristaltic pump 220 will not enter the silica gel tube 222 from the hydrophobic filter membrane 240, which to some extent ensures the dryness of the airway and is conducive to the long-term use of the filling system 1000.

[0077] In some embodiments, the second peristaltic pump 220 is configured to have a third working state and a fourth working state.

[0078] When the second peristaltic pump 220 is in the third working state, the second peristaltic pump 220 is configured to transport external gas to the inside of the liquid storage tank 210 through the hydrophobic filter membrane 240, so that the fluid in the liquid storage tank 210 bubbles uniformly under the action of the gas; when the second peristaltic pump 220 is in the fourth working state, the second peristaltic pump 220 is configured to make the fluid in the liquid storage tank 210 flow to the second liquid outlet needle 250.

[0079] In some embodiments, a first one-way valve 231 is arranged between the third port 2303 of the three-way connector 230 and the hydrophobic filter membrane 240; a second one-way valve 232 is arranged between the second port 2302 of the three-way connector 230 and the second liquid outlet needle 250, wherein the first one-way valve 231 is configured to allow external air to flow from the hydrophobic filter membrane 240 to the inside of the second filling assembly 200 in one direction; the second one-way valve 232 is configured to allow fluid to flow from the liquid storage tank 210 to the second liquid outlet needle 250 in one direction.

[0080] The first one-way valve 231 and the second one-way valve 232 respectively provide double safety protection for the third working state and the fourth working state of the second peristaltic pump 220.

[0081] In other embodiments, as shown in Figure 6 There is no one-way valve structure in the second filling assembly 200, and a pipe clamp structure is used to control the on-off of the fluid between the hydrophobic filter membrane 240, the second liquid outlet needle 250 and the inside of the liquid storage tank 210.

[0082] Specifically, as shown in Figure 6 The second port 2302 of the three-way connector 230 is connected with the hydrophobic filter membrane 240 through a silica gel tube, and the silica gel tube is provided with a first tube clamp structure 410. The third port 2303 of the three-way connector 230 is connected with the second liquid outlet needle 250 through a silica gel tube, and the silica gel tube is provided with a second tube clamp structure 420.

[0083] When the second peristaltic pump 220 is adjusted to the third working state, the first tube clamp structure 410 needs to be manually opened, and the second tube clamp structure 420 needs to be manually closed, so that the external gas is pumped into the liquid storage tank 210 through the hydrophobic filter membrane 240, and the radioactive stock solution or radioactive drug solution in the liquid storage tank 210 is further bubbled and mixed.

[0084] When the second peristaltic pump 220 is adjusted to the fourth working state, the first tube clamp structure 410 needs to be manually closed, and the second tube clamp structure 420 needs to be manually opened, so that the radioactive stock solution or radioactive drug solution in the liquid storage tank 210 is pumped out of the second filling assembly 200 through the second liquid outlet needle 250 and flows into the preparation bottle 330.

[0085] In some embodiments, the first peristaltic pump 120 and / or the second peristaltic pump 220 includes a pair of peristaltic pump tubes 221, so that the fluid is pumped along two branches.

[0086] The split pumping design is beneficial to reducing the pressure borne by the peristaltic pump tube 221 during pumping, beneficial to controlling the flow rate of the fluid, and can further mix the sediment in the peristaltic pump tube 221.

[0087] According to a second aspect of the embodiments of the present disclosure, a filling method is provided, which adopts the filling system 1000 of any one of the first aspect of the embodiments of the present disclosure to dilute and mix the to-be-diluted fluid and obtain a standard fluid with a predetermined concentration. When the first liquid outlet needle 130 is in the first working state, the filling system 1000 has a first filling method. When the first liquid outlet needle 130 is in the second working state, the filling system 1000 has a second filling method.

[0088] Specifically, the first filling method is dilution during filling, and the second filling method is filling after dilution. The filling system 1000 and the filling method provided by the present disclosure can realize two kinds of drug solution dilution and filling processes, and are suitable for selecting different dilution and filling methods according to different effective periods of different drug solutions.

[0089] In some embodiments, when the filling system 1000 uses the first filling method, the first liquid outlet needle 130 is separated from the first interface 211; the first filling method comprises: using the first filling assembly 100 to fill the diluent into the preparation bottle 330 at the first station; and using the second filling assembly 200 to fill the radioactive stock solution into the preparation bottle 330 at the second station.

[0090] Specifically, as shown in the first filling method, the diluent storage tank 310 is connected with the liquid inlet needle 110, and under the pumping action of the first peristaltic pump 120, the diluent can be transported from the liquid inlet needle 110 to the first liquid outlet needle 130, and finally flow out of the first filling assembly 100, and the diluent flows into the preparation bottle 330 at the first station according to the control ratio of the first peristaltic pump 120. Figure 2

[0091] When the first liquid outlet needle 130 proportionally transports the diluent to the preparation bottle 330, the preparation bottle 330 is moved from the first station to the second station. The second peristaltic pump 220 proportionally pumps the radioactive stock solution in the liquid storage tank 210 to the second liquid outlet needle 250, and at this time, the open mouth of the preparation bottle 330 is opposite to the second liquid outlet needle 250, and the radioactive stock solution flowing out of the second liquid outlet needle 250 can directly flow into the preparation bottle 330. The diluent and the radioactive stock solution complete dilution and mixing in the preparation bottle 330 to form a completed filling radioactive solution.

[0092] In some embodiments, the preparation bottle 330 can be filled at the second station first, and then filled at the first station. It should be noted that, in the first filling method, whether the preparation bottle is placed at the first station to fill the diluent first or placed at the second station to fill the radioactive stock solution first, it has no effect on the filling result.

[0093] Therefore, the disclosure does not limit the filling sequence of the first filling assembly 100 and the second filling assembly 200, and the preparation bottle can be filled at the first station first or at the second station first.

[0094] In some embodiments, before the radioactive stock solution is filled into the preparation bottle 330 at the second station by using the second filling assembly 200, the first filling method further comprises: transferring the radioactive stock solution from the infusion bottle 320 to the liquid storage tank 210; and introducing gas into the liquid storage tank 210 to make the radioactive stock solution in the liquid storage tank 210 bubble uniformly.

[0095] ​The second interface 212 of the liquid storage tank 210 is provided with a radioactive liquid bottle 320, and the radioactive liquid is transported into the liquid storage tank 210 through the radioactive liquid bottle 320. When the liquid storage tank 210 contains the radioactive liquid, the radioactive liquid may contain precipitates. At this time, external gas can be introduced into the liquid storage tank 210 to make the radioactive liquid in the liquid storage tank 210 bubble uniformly.

[0096] Specifically, after the radioactive liquid is transported into the liquid storage tank 210 through the radioactive liquid bottle 320, the second peristaltic pump 220 is adjusted to the third working state, and at this time, the second peristaltic pump 220 pumps the external gas into the liquid storage tank 210 through the hydrophobic filter membrane 240 to make the radioactive liquid in the liquid storage tank 210 bubble uniformly. After this action, the second peristaltic pump 220 is adjusted to the fourth working state, and the radioactive liquid in the liquid storage tank 210 is pumped out of the second filling assembly 200 in proportion, so that the radioactive liquid flows into the preparation bottle 330 in the second station and is mixed with the diluent.

[0097] In some embodiments, when the filling system 1000 uses the second filling method, the first liquid outlet needle 130 is connected to the first interface 211, and the second filling method includes: using the first filling assembly 100 to transport the diluent from the diluent storage tank 310 into the liquid storage tank 210 to dilute the original liquid in the liquid storage tank 210 into a diluted liquid; and using the second filling assembly 200 to fill the diluted liquid into the preparation bottle 330 in the third station.

[0098] It should be noted that the original liquid can be a radioactive liquid, and the radioactive liquid is mixed with the diluent to form a radioactive liquid.

[0099] When the filling system 1000 uses the second filling method, the first liquid outlet needle 130 is configured to be connected to the first interface 211, as shown in Figure 4 At this time, the liquid inlet needle 110 is connected to the diluent, the first liquid outlet needle 130 is connected to the first interface 211 of the second filling assembly 200, and the first peristaltic pump 120 is adjusted to make the diluent flow into the liquid storage tank 210 from the first interface 211 to dilute the radioactive liquid in the liquid storage tank 210.

[0100] By adjusting the second peristaltic pump 220, the radioactive liquid can be pumped from the liquid storage tank 210 to the second liquid outlet needle 250 to flow out of the second filling assembly 200, and when the preparation bottle 330 is in the third station, the second liquid outlet needle 250 is opposite to the open mouth of the preparation bottle 330.

[0101] In some embodiments, before the diluent is transferred into the storage tank 210 by the first filling assembly 100 to dilute the raw liquid in the storage tank 210 into a diluted liquid, the filling method further comprises: transferring the raw liquid from the infusion bottle 320 into the storage tank 210.

[0102] The infusion bottle 320 of the radioactive raw liquid is arranged on the second interface 212 of the storage tank 210, and the radioactive raw liquid can be proportionally delivered into the storage tank 210 through the infusion bottle 320, and then the diluent is transferred into the storage tank 210 by the first filling assembly 100 to dilute the radioactive raw liquid in the storage tank 210 into a radioactive liquid.

[0103] Further, the second peristaltic pump 220 is adjusted to the fourth working state to pump the radioactive liquid in the storage tank 210 out of the second filling assembly 200, so that the radioactive liquid flows into the preparation bottle 330 at the third station.

[0104] In some embodiments, before the radioactive liquid is filled into the preparation bottle 330 at the third station by the second filling assembly 200, the filling method further comprises: introducing gas into the storage tank 210 to make the radioactive liquid in the storage tank 210 bubble uniformly.

[0105] Specifically, after the radioactive raw liquid is mixed with the diluent in the storage tank 210, the second peristaltic pump 220 can be adjusted to the third working state, in which the first one-way valve 231 is open and the second one-way valve 232 is closed, so that the external gas is pumped into the storage tank 210 through the hydrophobic filter membrane 240, and the radioactive raw liquid in the storage tank 210 is further mixed with the diluent uniformly, that is, the radioactive liquid in the storage tank 210 is made to bubble uniformly.

[0106] After that, the second peristaltic pump 220 is adjusted to the fourth working state, in which the first one-way valve 231 is closed and the second one-way valve 232 is open, so that the radioactive liquid in the storage tank 210 is pumped out of the second filling assembly 200 by the second liquid outlet needle 250 and flows into the preparation bottle 330 at the third station.

[0107] The specific structure, working principle, and beneficial effects of the filling system 1000 and the filling method provided by the embodiments of the present disclosure can refer to the filling system 1000 and the filling method described in any of the above embodiments, which will not be repeated here.

[0108] Finally, it should be noted that the various embodiments in this specification are described in a progressive manner, with each embodiment focusing on its differences from other embodiments. References to the common and similar parts between the various embodiments will be sufficient. For the systems or devices disclosed in the embodiments, since they correspond to the methods disclosed in the embodiments, their descriptions are relatively simple; for relevant details, refer to the descriptions of the methods.

[0109] The above embodiments are only used to illustrate the technical solutions of the present disclosure, rather than to limit them. Although the present disclosure has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present disclosure.

Claims

1. A filling system, characterized in that: include: a first filling component, the first filling component including a liquid inlet needle and a first liquid outlet needle, configured to transfer the diluent; The second filling component includes a liquid storage tank and a second liquid outlet needle, and the liquid storage tank is provided with a first interface suitable for connecting with the first liquid outlet needle. Wherein, the first liquid outlet needle is configured to have a first working state separated from the first interface and a second working state connected to the first interface; When the first liquid outlet needle is in the first working state, the first filling assembly and the second filling assembly are configured to use the first liquid outlet needle and the second liquid outlet needle to deliver the diluent and the fluid to be diluted into the preparation bottle respectively; When the first liquid outlet needle is in the second working state, the first filling assembly and the second filling assembly are configured in an assembled state, the first filling assembly is configured to inject diluent into the liquid storage tank, dilute the fluid to be diluted in the liquid storage tank to form a standard fluid, and the second liquid outlet needle is used to transport the standard fluid into the preparation bottle.

2. The filling system according to claim 1, characterized in that The first filling component also includes: A first peristaltic pump, wherein both ends of the first peristaltic pump are respectively connected to the liquid inlet needle and the first liquid outlet needle, and the first peristaltic pump is configured to transport the diluent from the liquid inlet needle to the first liquid outlet needle.

3. The filling system according to claim 2, characterized in that The liquid storage tank is provided with a second interface for pouring the original drug solution, a third interface for installing the air filter element, and a liquid outlet for the fluid in the liquid storage tank to flow out.

4. The filling system according to claim 3, characterized in that The second filling component also includes: Three-way connector; a second peristaltic pump, two ends of the second peristaltic pump being connected to the liquid outlet of the liquid storage tank and the first port of the three-way connector respectively; and a hydrophobic filter membrane connected to the second port of the three-way connector; The second liquid outlet needle is connected to the third port of the three-way connector; In which, the second peristaltic pump is configured to have a third working state and a fourth working state. When the second peristaltic pump is in the third working state, the second peristaltic pump is configured to transport external gas into the liquid storage tank through the hydrophobic filter membrane so that the fluid in the liquid storage tank bubbles evenly under the action of the gas; when the second peristaltic pump is in the fourth working state, the second peristaltic pump is configured to make the fluid in the liquid storage tank flow to the second liquid outlet needle.

5. The filling system according to claim 4, characterized in that A first one-way valve is provided between the third port of the three-way connector and the hydrophobic filter membrane; A second one-way valve is provided between the second port of the three-way connector and the second liquid outlet needle. Among them, the first one-way valve is configured to allow external air to flow from the hydrophobic filter membrane to the inside of the second filling component in a one-way manner; the second one-way valve is configured to allow fluid to flow from the liquid storage tank to the second liquid outlet needle in a one-way manner.

6. The filling system according to claim 5, characterized in that The first peristaltic pump and / or the second peristaltic pump include peristaltic pump tubes arranged in pairs, so that the fluid is pumped along two branches.

7. A filling method, characterized in that: Using the filling system according to any one of claims 1 to 6 to dilute and mix the fluid to be diluted and obtain a standard fluid of a predetermined concentration; When the first liquid outlet needle is in a first working state, the filling system has a first filling method; when the first liquid outlet needle is in a second working state, the filling system has a second filling method.

8. The filling method according to claim 7, characterized in that: When the filling system uses the first filling method, the first liquid outlet needle is separated from the first interface; The first filling method includes: Filling the diluent into the preparation bottle at the first station using the first filling component; as well as The second filling assembly is used to fill the original drug solution into the preparation bottle located at the second station.

9. The filling method according to claim 8, characterized in that: Before using the second filling assembly to fill the original drug solution into the preparation bottle located at the second station, the first filling method further includes: Transferring the original solution to the storage tank; and Gas is introduced into the liquid storage tank so that the original drug solution in the liquid storage tank is bubbled evenly.

10. The filling method according to claim 9, characterized in that: When the filling system uses the second filling method, the first liquid outlet needle is docked with the first interface. The second filling method comprises: Using the first filling component to transfer the diluent into the liquid storage tank to dilute the original drug solution in the liquid storage tank into the diluted drug solution; and The diluted medicinal solution is filled into the preparation bottle located at the third station by using the second filling assembly.

11. The filling method according to claim 10, characterized in that: Before using the first filling component to transfer the diluent into the liquid storage tank to dilute the original drug solution in the liquid storage tank into the diluted drug solution, the filling method further includes: The original drug solution is transferred to the liquid storage tank.

12. The filling method according to claim 10 or 11, characterized in that: Before using the second filling component to fill the diluted medicinal solution into the preparation bottle located at the third station, the filling method further includes: Gas is introduced into the liquid storage tank so that the diluted liquid in the liquid storage tank is bubbled evenly.

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