An antibacterial hydrogel coating with hydrophilicity and its preparation method and application

Abstract

The application relates to the technical field of coating preparation, in particular to a preparation method of a hydrophilic antibacterial hydrogel coating, which comprises the following steps: after acrylic acid, 4-acryloyloxybenzophenone, a thermal initiator, water and N,N,N',N'-tetramethyl ethylenediamine are mixed and react in the dark, a polymer solution with photo-reaction is obtained; the polymer solution is mixed with a zwitterionic monomer, a crosslinking agent and water to obtain a coating liquid; a substrate is treated with 10wt% 4-acryloyloxybenzophenone organic solvent for 5-10 minutes, the obtained coating liquid is coated on the surface of the substrate, is cured under ultraviolet light, is immersed in water to remove unreacted substances, and a hydrophilic hydrogel coating is obtained; the obtained hydrophilic hydrogel coating is immersed in a 2-(N-morpholine)ethanesulfonic acid (MES) solution containing 0.4M EDC and 0.1M N-hydroxysuccinimide (NHS) to perform activation treatment; colistin sulfate is added into the above MES solution to perform activation treatment, and a hydrophilic antibacterial hydrogel coating is obtained.

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