An antibacterial hydrogel coating with hydrophilicity and its preparation method and application

By preparing a hydrophilic antibacterial hydrogel coating, the problem of bacterial infection in implants such as urinary catheters was solved, achieving high adhesion, stability and good biocompatibility, reducing the risk of infection and the difficulty of surgery.

CN116850350BActive Publication Date: 2026-06-12GUANGZHOU UNIVERSITY
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Patent Information

Application Number
CN202310715676.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-06-15
Publication Date
2026-06-12
Estimated Expiration
2043-06-15

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Abstract

The application relates to the technical field of coating preparation, in particular to a preparation method of a hydrophilic antibacterial hydrogel coating, which comprises the following steps: after acrylic acid, 4-acryloyloxybenzophenone, a thermal initiator, water and N,N,N',N'-tetramethyl ethylenediamine are mixed and react in the dark, a polymer solution with photo-reaction is obtained; the polymer solution is mixed with a zwitterionic monomer, a crosslinking agent and water to obtain a coating liquid; a substrate is treated with 10wt% 4-acryloyloxybenzophenone organic solvent for 5-10 minutes, the obtained coating liquid is coated on the surface of the substrate, is cured under ultraviolet light, is immersed in water to remove unreacted substances, and a hydrophilic hydrogel coating is obtained; the obtained hydrophilic hydrogel coating is immersed in a 2-(N-morpholine)ethanesulfonic acid (MES) solution containing 0.4M EDC and 0.1M N-hydroxysuccinimide (NHS) to perform activation treatment; colistin sulfate is added into the above MES solution to perform activation treatment, and a hydrophilic antibacterial hydrogel coating is obtained.
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