A flexible electrode and a method for preparing the same

Abstract

The present application discloses a flexible electrode and a preparation method thereof, wherein the flexible electrode comprises a protein microneedle and is provided with at least one implantation part; a flexible neural electrode comprises at least one implantation probe, and the implantation probe is at least partially fixedly connected to the implantation part; the number of the implantation parts corresponds to the number of the implantation probes; the present application can obtain a flexible electrode having a strength less than that of a blood vessel wall by combining the implantation part of the protein microneedle with the implantation probe of the flexible neural electrode, and the structure and number of the implantation part of the flexible electrode can be adjusted according to the structure and number of the implantation probes, and the preparation flexibility is high and the structure is simple; further, in the process of implantation using the flexible electrode, puncturing of the blood vessel can be avoided, thereby improving the safety of the implantation, and the protein microneedles in the flexible electrode can be dissolved in situ, thereby improving the accuracy and success rate of the implantation of the flexible electrode.

Description

Technical Field

[0001] The present application relates to the technical field of flexible electrodes, and in particular to a flexible electrode and a preparation method thereof. Background Art

[0002] With the continuous development of implantable flexible electrodes, they are widely used in neuroscience-related research, making flexible neural electrodes one of the core hardware of current brain-computer interface technology. However, since the strength of flexible neural electrodes is lower than that of brain tissue, they cannot penetrate the cerebral cortex for implantation alone, so an auxiliary shuttle device is required for implantation.

[0003] Currently, the more mature implantation method is to use tungsten wire as a shuttle device to assist in electrode implantation. However, this implantation technology is prone to puncturing blood vessels during the implantation process, causing intraoperative bleeding, which poses a potential risk. Moreover, after the electrode is implanted to a specified depth, the actual implantation depth will change during the removal process, making it impossible to achieve accurate brain area positioning and recording. Summary of the invention

[0004] In order to solve the technical problems of low accuracy and high risk of flexible electrode implantation, the present application discloses a method for preparing a flexible electrode that can solve the above technical problems.

[0005] In order to achieve the above-mentioned object of the invention, the present application provides a flexible electrode, comprising:

[0006] The protein microneedle has at least one implantation portion;

[0007] A flexible neural electrode, comprising at least one implant probe, wherein the implant probe is at least partially fixedly connected to the implant portion;

[0008] The number of the implanting parts corresponds one to one to the number of the implanting probes.

[0009] In some embodiments, a limiting structure is further included, wherein the limiting structure is used to limit the implantation depth of the implantation probe and the implantation part.

[0010] In some embodiments, the limiting structure is integrated on the protein microneedle;

[0011] The implantation portion includes an implantation end and a non-implantation end that are arranged opposite to each other;

[0012] The limiting structure is an arched structure formed from the implantation end toward the non-implantation end;

[0013] The distance between the bottom of the arch structure and the implantation end is equal to a preset implantation depth.

[0014] In some embodiments, the protein microneedle further comprises a fixing portion;

[0015] One end of the fixing portion is fixedly connected to the non-implantation end;

[0016] The other end of the fixing portion is fixedly connected to the flexible nerve electrode.

[0017] In some embodiments, the flexible neural electrode further comprises a connection portion, wherein the connection portion is used for communication connection with a processing device;

[0018] The connecting part is fixedly connected to the fixing part of the protein microneedle.

[0019] In some embodiments, the flexible neural electrode further comprises a silicon substrate, and the connecting portion is disposed on the silicon substrate;

[0020] The connecting portion is fixedly connected to the protein microneedle through the silicon substrate.

[0021] The present application also provides a method for preparing a flexible electrode, wherein the flexible electrode is the flexible electrode described above, and the method comprises:

[0022] preparing a flexible neural electrode and a protein microneedle corresponding to the flexible neural electrode;

[0023] The implanted portion of the protein microneedle and the implanted probe of the flexible neural electrode are fixed with a preset degradable solution to obtain a preliminary flexible electrode;

[0024] The initially prepared flexible electrode is dried to obtain a flexible electrode.

[0025] In some embodiments, the method of fixing the implanted portion of the protein microneedle and the implanted probe of the flexible neural electrode with a preset degradable solution to obtain a preliminary flexible electrode comprises:

[0026] Applying the preset degradable solution on the surface of the implant part, placing the implant probe on the implant part, and letting it stand and dry;

[0027] The preset degradable solution is applied to the surface of the implanted probe, left to stand, and dried to obtain a preliminary flexible electrode.

[0028] In some embodiments, the protein microneedle corresponding to the flexible neural electrode includes:

[0029] Taking a preset substrate;

[0030] Pre-treating the surface of a preset substrate to obtain a target substrate;

[0031] placing a protein solution on the target substrate and covering the target substrate;

[0032] Drying the target substrate covered with the protein solution to obtain a protein film;

[0033] The protein film is cut according to the flexible neural electrode to obtain the protein microneedle.

[0034] In some embodiments, the flexible electrode includes a connecting portion, and the protein microneedle includes a fixing portion; before fixing the implanted portion of the protein microneedle and the implanted probe of the flexible neural electrode using a preset degradable solution to obtain the flexible electrode, the method further includes:

[0035] The connecting part is fixedly connected to the fixing part by using a preset adhesive.

[0036] Implementing the embodiments of the present application has the following beneficial effects:

[0037] The flexible electrode of the present application can obtain a flexible electrode with strength less than that of the blood vessel wall by combining the implantation part of the protein microneedle with the implantation probe of the flexible neural electrode. The structure and number of the implantation part of the flexible electrode can be adjusted according to the structure and number of the implantation probe, and the preparation flexibility is high and the structure is simple. Furthermore, in the process of implantation using the flexible electrode, puncturing of the blood vessels can be avoided, thereby improving the safety of the implantation, and the protein microneedles in the flexible electrode can be dissolved in situ, which can improve the implantation accuracy and success rate of the flexible electrode. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] In order to more clearly illustrate the flexible electrode and the preparation method thereof described in the present application, the drawings required for the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0039] Figure 1 A schematic diagram of the structure of a flexible electrode provided in an embodiment of the present application;

[0040] Figure 2 A schematic diagram of a flexible neural electrode structure provided in an embodiment of the present application.

[0041] Figure 3 A schematic diagram of the structure of a protein microneedle provided in an embodiment of the present application;

[0042] Figure 4 A schematic diagram of an exemplary structure of a protein microneedle provided in an embodiment of the present application;

[0043] Figure 5 A schematic diagram of a process for preparing a flexible electrode provided in an embodiment of the present application;

[0044] Figure 6 A schematic diagram of a process for preparing a protein microneedle provided in an embodiment of the present application.

[0045] Among them, the corresponding reference numerals in the figure are: 1-protein microneedle, 101-implantation part, 102-fixation part, 103-limiting structure, 2-flexible neural electrode, 201-implantation probe, 2011-electrode point, 202-connection part, 203-silicon substrate. DETAILED DESCRIPTION

[0046] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0047] It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchangeable where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "having" and any of their variations are intended to cover non-exclusive inclusions, for example, a process, method, system, product or server that includes a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0048] See also Figures 1 to 4 As shown, the present application provides a flexible electrode, comprising: a protein microneedle 1, provided with at least one implantation portion 101;

[0049] In some exemplary embodiments, the protein microneedle 1 may include, but is not limited to, a silk protein microneedle or a spider silk protein microneedle.

[0050] In some exemplary embodiments, the implant part 101 may be a needle-shaped structure or a column-shaped structure.

[0051] The flexible neural electrode 2 comprises at least one implant probe 201, wherein the implant probe 201 is at least partially fixedly connected to the implant part 101;

[0052] In some exemplary embodiments, the implant probe 201 includes all electrode points 2011 on the flexible neural electrode 2 .

[0053] In one example, at least the portion of the implant probe 201 including all electrode points 2011 is fixedly connected to the implant part 101 .

[0054] In some exemplary embodiments, the structural shape of the implant part 101 may match the structural shape of the implant probe 201 .

[0055] The number of the implanting parts 101 corresponds to the number of the implanting probes 201 .

[0056] In some exemplary embodiments, the number of implant parts 101 can be adjusted according to the number of implant probes.

[0057] In this embodiment, the present application can obtain a flexible electrode whose strength is less than that of the blood vessel wall by combining the implantation part of the protein microneedle with the implantation probe of the flexible neural electrode. The flexible electrode has a simple structure, and the structure and number of the implantation part can be adjusted according to the structure and number of the implantation probe, and the preparation flexibility is high. Furthermore, in the process of implantation using the flexible electrode, puncturing of the blood vessels can be avoided, thereby improving the safety of the implantation, and the protein microneedles in the flexible electrode can be dissolved in situ, which can improve the implantation accuracy and success rate of the flexible electrode.

[0058] In some exemplary embodiments, the flexible electrode further includes a limiting structure 103 , and the limiting structure 103 is used to limit the implantation depth of the implantation probe 201 and the implantation part 101 .

[0059] In one example, the limiting structure 103 may be disposed on a side of the implantation probe 201 away from the implantation portion 101 and fixedly connected to the implantation probe.

[0060] In this embodiment, the limiting structure is provided to facilitate limiting the implantation depth of the electrode during the implantation of the flexible electrode.

[0061] In one example, if Figure 1 and Figure 3 As shown, the limiting structure 103 can be integrated on the protein microneedle 1;

[0062] The implantation part 101 includes an implantation end and a non-implantation end that are arranged opposite to each other;

[0063] The limiting structure 103 is an arched structure formed from the implantation end to the non-implantation end;

[0064] In some examples, the number of the limiting structures 103 is different depending on the number of implant parts 101.

[0065] In one example, when the number of implant parts 101 is 2, the number of limiting structures 103 is one; when the number of implant parts 101 is more than 2, the number of limiting structures 103 is the number of implant parts minus 1.

[0066] The distance between the bottom of the arch structure and the implantation end is equal to a preset implantation depth.

[0067] In one example, if Figure 4 As shown, the heights of each limiting structure 103 may be equal or unequal.

[0068] In this embodiment, the present application directly integrates the limiting structure 103 on the protein microneedle 1, which not only simplifies the structure of the flexible electrode, but also can simultaneously obtain the limiting height of the limiting structure 103 when designing the implantation part 101 according to the preset implantation depth, which is more convenient.

[0069] In some exemplary embodiments, Figure 3 and Figure 4 As shown, the protein microneedle 1 further includes a fixing portion 102;

[0070] One end of the fixing portion 102 is fixedly connected to the non-implantation end;

[0071] In one example, the fixing portion 102 may be integrally formed with the non-implantation end.

[0072] The other end of the fixing portion 102 is fixedly connected to the flexible nerve electrode 2 .

[0073] In this embodiment, by increasing the connection between the fixing portion 102 and the flexible nerve electrode 2, the stability of the connection between the protein microneedle and the flexible nerve electrode can be improved.

[0074] The mechanical properties of the protein microneedle of the present application are between those of brain tissue and blood vessels, and can pierce the cortex for implantation. During the implantation process, puncture of blood vessels can be avoided, craniotomy and intraoperative bleeding can be avoided, surgical trauma can be reduced, and the safety of implantation can be improved.

[0075] In some exemplary embodiments, Figure 2 As shown, the flexible neural electrode 2 further includes a connecting portion 202, and the connecting portion 202 is used for communication connection with a processing device;

[0076] The connecting portion 202 is fixedly connected to the fixing portion 102 of the protein microneedle 1 .

[0077] In one example, the processing device may be a flexible circuit board.

[0078] In one example, a transition portion is also included, and the transition portion is used to limit the wire to reduce the size of the flexible neural electrode.

[0079] Specifically, Figure 2 As shown, the transition portion is disposed between the connecting portion 202 and the implantation probe 201 , and is used to perform transition limiting on the wire connected to the implantation probe 201 between the implantation probe 201 and the connecting portion 202 .

[0080] In this embodiment, by fixedly connecting the connecting portion 202 to the fixing portion 102 of the protein microneedle 1 , the stability of the connection between the flexible electrode and the protein microneedle can be improved.

[0081] In some exemplary embodiments, the flexible neural electrode 2 further includes a silicon substrate 203, and the connecting portion 202 is disposed on the silicon substrate 203;

[0082] The connecting portion 202 is fixedly connected to the protein microneedle 1 through the silicon substrate 203 .

[0083] In one example, the connecting portion 202 is fixedly connected to the fixing portion 102 on the protein microneedle 1;

[0084] Specifically, the connecting portion 202 and the fixing portion 102 are arranged on opposite sides of the silicon substrate 203;

[0085] The connecting portion 202 and the fixing portion 102 are both fixedly connected to the silicon substrate 203 .

[0086] In this embodiment, the present application arranges the connection part 202 on the silicon substrate 203 so that the connection part 202 is connected to the processing device through the silicon substrate 203, which can facilitate the connection of the connection part 202 with the back-end processing device.

[0087] It should be noted that the flexible electrode of the present application is not limited to the above structure, and when the structure of the flexible neural electrode is determined, the structure of the flexible electrode is also not limited to the above structure.

[0088] In some exemplary embodiments, Figure 5 , which is a schematic flow chart of a method for preparing a flexible electrode provided in an embodiment of the present application. The flexible electrode is the flexible electrode shown in the above embodiment. Specifically, the method includes:

[0089] S501, preparing a flexible neural electrode and a protein microneedle corresponding to the flexible neural electrode;

[0090] In some exemplary embodiments, flexible neural electrodes that meet implantation requirements can be prepared according to implantation requirements;

[0091] Specifically, the flexible neural electrode can be prepared using known techniques.

[0092] In some exemplary embodiments, a protein film may be prepared, and further, the protein film may be cut according to the flexible neural electrode to obtain the protein microneedle.

[0093] In one example, known techniques can be used to prepare the protein film.

[0094] Furthermore, protein microneedles can be obtained by CNC (Computer numerical control, protein film is processed using computer numerical control machine tools) and laser cutting.

[0095] S503, using a preset degradable solution to fix the implanted portion of the protein microneedle and the implanted probe of the flexible neural electrode to obtain a preliminary flexible electrode;

[0096] In the embodiment of the present application, the preset degradable solution may refer to a biocompatible degradable solution; as an example, the preset degradable solution is any one of a polyethylene glycol solution and a silk protein solution.

[0097] Specifically, when the preset degradable solution is a polyethylene glycol solution, the polyethylene glycol solution is a saturated polyethylene glycol solution, and the molecular weight of the solution may be 35,000.

[0098] When the preset degradable solution is a silk protein solution, the degumming time of the silk protein solution may include but is not limited to 15, 30, 60, and 120 minutes. The longer the degumming time, the better the solubility of the silk protein solution and the lower the strength.

[0099] In some exemplary embodiments, the preset degradable solution is applied to the surface of the implant part, and then the implant probe is placed on the implant part, left to stand, and dried; the preset degradable solution is applied to the surface of the implant probe, left to stand, and dried to obtain a preliminary flexible electrode. This treatment method can be performed at room temperature.

[0100] In one example, the electrode can be placed on a platform, dipped in a small amount of saturated polyethylene glycol solution or silk protein solution, and applied to the surface of the implant part of the protein microneedle, and the implant probe can be picked up and placed on the surface of the implant part coated with the solution. When the implant probe comes into contact with the saturated polyethylene glycol solution or silk protein solution, it will adhere to the surface of the implant part of the protein microneedle. After the saturated polyethylene glycol solution or silk protein solution dries, another layer of saturated polyethylene glycol solution or silk protein solution is brushed on the surface of the implant probe to completely wrap the implant probe. After the saturated polyethylene glycol solution or silk protein solution is completely solidified, the implant probe is fixed to the implant part.

[0101] In this example, the ambient humidity is generally within 40%.

[0102] Optionally, in the case where the flexible electrode includes a connecting portion and the protein microneedle includes a fixing portion, before the implantation portion of the protein microneedle and the implantation probe of the flexible neural electrode are fixed with a preset degradable solution to obtain the flexible electrode, the method may further include:

[0103] The connection part is fixedly connected to the fixing part by using a preset adhesive; wherein the preset adhesive may be glue, and as an example, the preset adhesive may be epoxy resin glue.

[0104] In one example, a connecting portion is formed on a silicon substrate, and correspondingly, epoxy resin glue is applied on the opposite side of the silicon substrate where the connecting portion is located, and then the fixing portion of the protein microneedle is aligned with the silicon substrate and adhered to the silicon substrate. The connection portion is allowed to stand for 5 minutes until the glue solidifies, thereby achieving a fixed connection between the connecting portion and the fixing portion.

[0105] By fixedly connecting the connecting part and the fixing part, the connection stability between the protein microneedle and the flexible nerve electrode can be improved.

[0106] S505, drying the initially prepared flexible electrode to obtain a flexible electrode.

[0107] In some exemplary embodiments, the initially prepared flexible electrode can be placed in a drying cabinet with an ambient humidity of 8% to 10% and left to stand for 30 minutes to obtain a flexible electrode.

[0108] In one example, if the protein microneedle bends during the combination fixation process due to high environmental humidity, contact with liquid, etc., a heavy object (>100 g) can be placed on the microneedle to flatten the bent protein microneedle.

[0109] In this embodiment, the present application uses a preset degradable solution to fixedly connect the implantation probe of the flexible neural electrode with the implantation part of the protein microneedle, so that the flexible electrode can be implanted in the body while avoiding damage to blood vessels, etc. by the flexible electrode, thereby improving the safety of the flexible electrode implantation; and the preset degradable solution and protein microneedle used can make it possible for auxiliary parts such as the preset degradable solution and protein microneedle to dissolve in situ after the flexible electrode is implanted in the body, thereby avoiding the influence of pulling out the auxiliary parts on the implantation depth, thereby improving the accuracy and success rate of the flexible electrode implantation.

[0110] In some exemplary embodiments, Figure 6 , which is a schematic diagram of a method for preparing a protein microneedle provided in an embodiment of the present application, as follows:

[0111] S601, taking a preset substrate;

[0112] In the embodiment of the present application, the preset substrate may be an acrylic plate.

[0113] S603, pre-treating the surface of a preset substrate to obtain a target substrate;

[0114] In an embodiment of the present application, plasma may be used to treat the surface of a preset substrate, and then the surface may be cleaned to obtain a target substrate.

[0115] This method can improve the hydrophilicity of the substrate and facilitate the subsequent preparation of protein films.

[0116] S605, placing the protein solution on the target substrate and covering the target substrate;

[0117] In some exemplary embodiments, the protein solution may be poured onto the target substrate, and after it is naturally dispersed, it may be spread using a stirring rod or other tool to completely cover the target substrate.

[0118] In one example, before pouring the protein solution onto the target substrate, polyimide tape may be pasted around the target substrate to prevent the protein solution from spreading outside the target substrate by utilizing its hydrophobic properties.

[0119] S607, drying the target substrate covered with the protein solution to obtain a protein film;

[0120] In some exemplary embodiments, the protein solution can be placed in a drying cabinet with an ambient humidity of 8%-10% and allowed to stand for 24-36 hours to dry into a film to obtain a protein film.

[0121] In one example, nitrogen gas may be introduced into the drying cabinet to increase the speed of film formation.

[0122] S609, cutting the protein film according to the flexible neural electrode to obtain protein microneedles.

[0123] In some exemplary embodiments, protein microneedles can be obtained by processing using CNC, laser cutting, etc. according to the structural shape of the flexible neural electrode.

[0124] In one example, parameters such as the number, width, length, and spacing of the implanted parts can be adjusted according to the structure of the flexible neural electrode.

[0125] In this embodiment, the protein microneedles are prepared by cutting the protein film, and the structure of the protein microneedles can be flexibly adjusted according to the structure of the flexible neural electrode, thereby improving the applicability and processing convenience of the protein microneedles.

[0126] The above description is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. A flexible electrode, characterized in that: include: A protein microneedle (1) is provided with at least one implantation portion (101), wherein the protein microneedle (1) comprises a silk protein microneedle or a spider silk protein microneedle, and the protein microneedle (1) can be dissolved in situ after being implanted in the body; A flexible neural electrode (2), comprising at least one implant probe (201), wherein at least a portion of the implant probe (201) is fixedly connected to the implant part (101); the number of the implant parts (101) corresponds to the number of the implant probes (201); A limiting structure (103), the limiting structure (103) being an arched structure formed from the implantation end of the implantation part (101) toward the non-implantation end of the implantation part (101), the limiting structure (103) being integrated on the protein microneedle (1), and the limiting structure (103) being used to limit the implantation depth of the implantation probe (201) and the implantation part (101); The flexible neural electrode (2) is placed on a platform, dipped in a small amount of saturated polyethylene glycol solution or silk protein solution, and applied to the surface of the implantation part (101) of the protein microneedle (1). The implantation probe (201) is lifted and placed on the surface of the implantation part (101) coated with the solution. When the implantation probe (201) contacts the saturated polyethylene glycol solution or silk protein solution, it adheres to the surface of the implantation part (101) of the protein microneedle (1). After the saturated polyethylene glycol solution or silk protein solution dries, another layer of saturated polyethylene glycol solution or silk protein solution is applied to the surface of the implantation probe (201) to completely wrap the implantation probe (201). After the saturated polyethylene glycol solution or silk protein solution is completely solidified, the implantation probe (201) is fixed to the implantation part (101). The mechanical properties of the protein microneedle (1) are between those of brain tissue and blood vessels, and the protein microneedle (1) can be implanted through the cortex, and blood vessels can be avoided from being punctured during the implantation process.

2. The flexible electrode according to claim 1, characterized in that: The implantation part (101) comprises an implantation end and a non-implantation end which are arranged opposite to each other; The distance between the bottom of the arch structure and the implantation end is equal to a preset implantation depth.

3. The flexible electrode according to claim 2, characterized in that: The protein microneedle (1) further includes a fixing portion (102); One end of the fixing portion (102) is fixedly connected to the non-implantation end; The other end of the fixing portion (102) is fixedly connected to the flexible nerve electrode (2).

4. The flexible electrode according to claim 3, characterized in that: The flexible neural electrode (2) further comprises a connection portion (202), wherein the connection portion (202) is used for communication connection with a processing device; The connecting portion (202) is fixedly connected to the fixing portion (102) of the protein microneedle (1).

5. The flexible electrode according to claim 4, characterized in that: The flexible neural electrode (2) further comprises a silicon substrate (203), and the connecting portion (202) is arranged on the silicon substrate (203); The connecting portion (202) is fixedly connected to the protein microneedle (1) via the silicon substrate (203).

6. A method for preparing a flexible electrode, characterized in that: The flexible electrode is a flexible electrode according to any one of claims 1 to 5, and the method comprises: preparing a flexible neural electrode and a protein microneedle corresponding to the flexible neural electrode; The implanted portion of the protein microneedle and the implanted probe of the flexible neural electrode are fixed with a preset degradable solution to obtain a preliminary flexible electrode; The initially prepared flexible electrode is dried to obtain a flexible electrode.

7. The method for preparing a flexible electrode according to claim 6, characterized in that: The method of fixing the implanted portion of the protein microneedle and the implanted probe of the flexible neural electrode with a preset degradable solution to obtain a preliminary flexible electrode comprises: Applying the preset degradable solution on the surface of the implant part, placing the implant probe on the implant part, and letting it stand and dry; The preset degradable solution is applied to the surface of the implanted probe, left to stand, and dried to obtain a preliminary flexible electrode.

8. The method for preparing a flexible electrode according to claim 6, characterized in that: The protein microneedle corresponding to the flexible neural electrode includes: Taking a preset substrate; Pre-treating the surface of a preset substrate to obtain a target substrate; placing a protein solution on the target substrate and covering the target substrate; Drying the target substrate covered with the protein solution to obtain a protein film; The protein film is cut according to the flexible neural electrode to obtain the protein microneedle.

9. The method for preparing a flexible electrode according to claim 6, characterized in that: The flexible electrode includes a connecting portion, and the protein microneedle includes a fixing portion; before fixing the implanted portion of the protein microneedle and the implanted probe of the flexible neural electrode with a preset degradable solution to obtain the flexible electrode, the method further includes: The connecting part is fixedly connected to the fixing part by using a preset adhesive.

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