An external cosmetic composition for acne treatment and repair and use thereof

Abstract

The present application relates to the field of cosmetic technology, and discloses a kind of externally used cosmetic composition.The composition includes the following weight parts of effective component: azelaic acid 0.1-30 parts, farnesol 0.01-2 parts, white willow bark extract 0.01-5 parts, Egyptian blue lotus flower extract 0.01-5 parts, kale extract 0.01-5 parts and yarrow extract 0.1-5 parts.The present application also provides the use of the composition, which has the effect of bacteriostasis and anti-inflammation, and improves skin sebum secretion, so that it can be used for acne, fade acne marks, and repair various skin damage caused by acne, and for preparing various externally used cosmetic preparations, such as essence, emulsion, cream, etc.for anti-acne repair.In addition, the effective components contained in the composition include natural plant extracts, which can effectively reduce the irritation of azelaic acid to the skin, and help the composition to maintain a good skin feel of mildness and non-irritation.

Description

Technical Field

[0001] This invention relates to the field of cosmetics, specifically to a topical cosmetic composition for acne treatment and repair, and its application. Background Technology

[0002] Acne is a chronic inflammatory skin disease of the pilosebaceous unit that commonly occurs during adolescence and primarily affects the face. The exact pathogenesis is not yet fully understood. Factors such as genetics, androgen-induced excessive sebum secretion, keratinization of the pilosebaceous duct, proliferation of Propionibacterium acnes, inflammation, and immune response may all be related to it.

[0003] The rapid development of sebaceous glands and excessive lipid secretion under the influence of androgens are the pathophysiological basis of acne. During puberty, the development of the adrenal glands and gonads leads to increased secretion of androgen precursors such as dehydroepiandrosterone sulfate (DHEAs), which are then converted into active dihydrotestosterone by a series of androgen-metabolizing enzymes, such as 5α-reductase, stimulating enhanced sebaceous gland function. Increased expression or activity of androgen receptors or related androgen-metabolizing enzymes in the skin under a genetic background is also an important factor contributing to the sebaceous glands' hypersensitivity to androgens and excessive lipid secretion. Furthermore, acne patients exhibit altered lipid composition in their sebum, including increased levels of squalene peroxide, wax esters, and free fatty acids, an increased proportion of unsaturated fatty acids, and decreased linoleic acid content. These changes can lead to impaired skin barrier function, keratinization of the pilosebaceous duct, and inflammatory responses.

[0004] Abnormal keratinization of the pilosebaceous duct is another important factor and major pathological phenomenon in the development of acne. Epithelial cell keratinization leads to blockage of the pilosebaceous duct and impaired sebum excretion, eventually forming microcomedones visible under a microscope and comedones visible to the naked eye. Pro-inflammatory factors such as interleukin (IL)-1α, androgens, free fatty acids, and lipid peroxides may be related to abnormal duct keratinization.

[0005] Propionibacterium acnes is closely related to the occurrence of acne. The formation of microcomedones and comedones creates a favorable local environment for the proliferation of Propionibacterium acnes, which has anaerobic growth characteristics. Currently, it is believed that Propionibacterium acnes may participate in the development and progression of acne inflammation through innate immunity, acquired immunity, and direct induction. Early acne inflammation may be caused by a Toll-like receptor (TLR)-mediated innate immune response, inducing the release of pro-inflammatory factors, especially IL-1α. As the disease progresses, the acquired immune response amplifies the inflammatory process, further leading to the release of inflammatory factors and neutrophil aggregation. Propionibacterium acnes can also produce polypeptides that directly induce or aggravate inflammation. In the later stages of the disease, the hair follicle wall ruptures, allowing lipids, hair, and other substances from the hair follicle to enter the dermis, further exacerbating the inflammatory response.

[0006] Studies have found that over 95% of people in my country experience acne to varying degrees. Acne leaves red or dark marks, and 3% to 7% of acne patients develop scars, significantly impacting their appearance and overall well-being. Common acne sequelae include post-acne erythema, post-acne hyperpigmentation, and post-acne scarring.

[0007] Post-acne erythema: Acne is often accompanied by inflammation. When acne subsides, the dilated blood vessels do not immediately contract. Blood flow also slows down after inflammation. Red blood cells and platelets tend to aggregate locally, causing poor circulation. The blood at the lesion site will appear dark red, which is post-acne erythema, or red acne marks.

[0008] Post-acne hyperpigmentation: Post-acne hyperpigmentation, also known as dark acne scars, is caused by increased skin pigment synthesis due to inflammatory stimulation. Through internal and external stimuli, melanin production is activated, leading to the formation of dark acne scars.

[0009] Therefore, effective and timely intervention in the early stages of acne to prevent its further development and deterioration, and improving the condition of acne lesions and alleviating post-acne scars and pigmentation in the later stages of treatment, are of significant clinical importance. However, existing acne treatment compositions have relatively simple ingredients, mostly containing only antibacterial and soothing components, and cannot treat or alleviate post-acne pigmentation. There is an urgent need to develop more acne treatment compositions that can simultaneously reduce red acne marks and melanin pigmentation, providing comprehensive treatment throughout the acne cycle from onset to resolution, and reducing the occurrence of acne sequelae.

[0010] Azelaic acid is a common organic acid-based acne treatment ingredient. However, acids can irritate and damage the skin. The probability of adverse reactions increases with the variety, concentration, and duration of contact with the skin in the composition. When the acid concentration is too high or the overall ratio is unsuitable, patients may experience temporary erythema, swelling, stinging, burning, or even crusting, pigmentation, burns, erosion, exudation, abnormal pigmentation, reactive acne, milia, telangiectasia, contact urticaria, and scarring. How to achieve an appropriate ratio to maximize the effectiveness of the acid-containing composition while minimizing these adverse reactions and ensuring a gentle, skin-friendly formula remains a crucial issue that urgently needs to be researched and resolved in acne treatment compositions. Summary of the Invention

[0011] The purpose of this invention is to overcome the shortcomings of the prior art and provide an acne-removing composition with good moisturizing properties and skin feel, which has the effects of removing acne and treating post-acne sequelae. On the one hand, this composition can inhibit bacteria, reduce the number of acne bacteria, and remove acne. On the other hand, this composition can also specifically reduce the occurrence of post-acne sequelae: the composition can inhibit sebaceous gland activation, accelerate keratin shedding to keep pores open, and reduce inflammation through anti-oxidation and anti-inflammation, ultimately achieving effective treatment of post-acne sequelae and realizing a full-stage acne treatment effect.

[0012] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0013] In a first aspect, the present invention provides a cosmetic composition for external use.

[0014] In one embodiment of the present invention, the composition comprises: azelaic acid, bisabolol, white willow bark extract, Egyptian blue water lily extract, kale leaf extract and yarrow extract;

[0015] In one embodiment of the present invention, the composition comprises, by weight parts: 0.01-30 parts azelaic acid, 0.01-2 parts bisabolol, 0.01-5 parts white willow bark extract, 0.01-5 parts Egyptian blue water lily extract, 0.01-5 parts kale extract and 0.1-5 parts yarrow extract;

[0016] In one embodiment of the present invention, the composition comprises, by weight parts: 0.1-20 parts azelaic acid, 0.01-1.5 parts bisabolol, 0.1-4 parts white willow bark extract, 0.1-3 parts Egyptian blue water lily extract, 0.1-3 parts kale extract and 0.1-3 parts yarrow extract;

[0017] The white willow bark extract described herein uses willow bark from willow branches as raw material. The raw material is cut into small pieces, soaked in ethanol for 2 to 3 days, and the filtrate is evaporated to obtain a solid. The solid is then dissolved in water to obtain the white willow bark extract. The main component of the white willow bark extract is salicin, in addition to which it also contains flavonoids and phenolic substances. Its main active ingredients have the following main functions: Salicin is an oxidase inhibitor and can regulate gene groups related to the biological process of skin aging, thus having anti-wrinkle and anti-aging effects, and increasing skin luster and elasticity. It is also commonly used in the pharmaceutical field to treat fever, relieve osteoarthritis pain, and lower back pain; Flavonoids have anti-free radical and antioxidant effects, and have good effects in preventing and treating cardiovascular diseases, such as preventing arteriosclerosis, lowering blood lipids and cholesterol, and reducing the incidence of coronary heart disease.

[0018] Egyptian blue water lily extract was prepared using dried blue water lily flowers. The dried flowers were extracted three times by refluxing with 70% ethanol (v / v) for 1 hour each time. The extracts were combined, concentrated under reduced pressure to obtain a paste, and dried under reduced pressure to obtain a 70% ethanol extract. The extract was then purified using a macroporous adsorption resin column, yielding 30% and 50% ethanol eluates. Egyptian blue water lily extract is rich in 17 amino acids and contains various plant polyphenols and flavonoids, such as quercetin, kaempferol, and myricetin. Current technology indicates that the polyphenols and flavonoids in Egyptian blue water lily extract possess ABTS free radical scavenging activity, antioxidant capacity, and selective α-glucosidase inhibitory activity, exhibiting excellent antioxidant and hypoglycemic activities. Therefore, it can be used as a food and medicinal plant in the food and pharmaceutical industries.

[0019] Kale leaf extract is prepared from dried kale leaves. Fresh kale leaves are washed, dried, pulverized, and sieved to obtain kale powder. Ethanol is added to the powder and stirred for 6 hours at room temperature. After centrifugation of the filtrate, the residue is discarded, and the supernatant is collected. The supernatant is then evaporated under vacuum at 50°C to prepare the kale leaf ethanol extract. Kale leaf extract contains a large amount of lutein, a carotenoid, and is rich in flavonols, anthocyanins, and other flavonoids. Current technology indicates that kale leaf extract has a protective effect against cellular oxidative stress, delaying cell death caused by oxidative damage and cellular oxidative damage itself, and possessing physiological functions such as preventing cardiovascular disease and regulating immunity. Simultaneously, it can inhibit the secretion of inflammatory cytokines such as IL-8, helping to control intestinal inflammatory responses triggered by oxidative stress and alleviating certain intestinal diseases associated with inflammatory responses.

[0020] Yarrow extract is prepared from the stems, leaves, and flowers of yarrow. Yarrow is pulverized to 60 mesh to obtain yarrow powder. This powder is extracted twice with 90% ethanol at 65°C. The extracts are combined, filtered, and the filtrate is concentrated into an extract. This extract is purified using macroporous resin, eluted with 95% ethanol, and the eluent is collected in fractions and concentrated into a thick paste to obtain the yarrow extract. Yarrow extract is rich in organic acids such as succinic acid, fumaric acid, and α-vinylcarboxylic acid, and also contains flavonoid glycosides. Current technology indicates that these organic acids have antibacterial, anti-inflammatory, antipyretic, and analgesic effects; flavonoid glycosides can reduce melanosome transport and melanocyte dendrite growth, thereby inhibiting melanin transport to keratinocytes, achieving a certain effect of brightening skin tone and improving pigmentation; simultaneously, yarrow extract can effectively inhibit elastase, restoring the elasticity and balance of skin fibrous tissue and accelerating skin cell metabolism.

[0021] In one embodiment of the present invention, the composition may further include excipients;

[0022] In one embodiment of the present invention, the excipients may be selected from one or more of humectants, emulsifiers, foaming agents, pH adjusters, preservatives and thickeners;

[0023] In one embodiment of the present invention, the moisturizer is selected from one or more of glycerin, propylene glycol, 1,3-butanediol, 1,2-hexanediol, pentanediol, dipropylene glycol, trehalose, betaine, panthenol, nicotinamide, maltose, β-glucan, sodium lactate, polyvinylpyrrolidone, polyquaternium-51, sorbitol, caprylyl glycol, ethylhexylglycerin, PEG-200, PEG-400, and glyceryl polyether-26;

[0024] In one embodiment of the present invention, the emulsifier is selected from cetearyl alcohol, cetearyl alcohol polyether-21, glyceryl stearate, PEG-100 stearate, PEG-15 glyceryl stearate, PEG-20 glyceryl stearate, PEG-30 glyceryl stearate, PEG-40 glyceryl stearate, polysorbate-20, polysorbate-40, polysorbate-60, polysorbate-80, polysorbate-85, and polysorbate-20. One or more of the following: glycerol-10 diisostearate, polyglycerol-10 distearate, polyglycerol-10 myristate, polyglycerol-10 isostearate, polyglycerol-10 laurate, polyglycerol-10 stearate, polyglycerol-10 oleate, polyglycerol-5 stearate, behenyl ether-10, behenyl ether-20, behenyl ether-25, behenyl ether-30, cetearyl glucoside, and sorbitan olive oil ester;

[0025] In one embodiment of the present invention, the pH adjuster is selected from one or more of citric acid, sodium citrate, sodium hydroxide, and sodium potassium dehydroacetate;

[0026] In one embodiment of the present invention, the foaming agent is selected from one or more of the following: cocamidopropyl betaine, sodium cocoyl glycinate, sodium cocoaminopropionate, sodium cocoyl hydroxyethanesulfonate, sodium laureth sulfate, ammonium laureth sulfate, sodium laureth sulfate, cocamidopropyl hydroxysulfonate, sodium lauroyl sarcosinate, potassium laurate, sodium methylcocoyl taurate, sodium methyl lauroyl taurate, sodium laureth-6 carboxylate, laureth-16, decyl glucoside, lauryl hydroxysulfonate, and disodium cocoamphodiacetate.

[0027] In one embodiment of the present invention, the preservative is selected from one or more of phenoxyethanol, p-hydroxyacetophenone, ethylhexylglycerin, caprylyl glycol, capryloyl hydroxamic acid, 1,2-hexanediol, and benzoic acid; the thickener is selected from one or more of carbomer, acrylic acid (type) / C10-30 alkanol acrylate crosspolymer, xanthan gum, Sphingomonas sphingosine fermentation extract, hydroxyethyl cellulose, and ammonium acryloyl dimethyl taurate / VP copolymer; the oil is selected from one or more of squalane, isohexadecane, dioctyl carbonate, hydrogenated polydecene, hydrogenated polyisobutylene, silicone oil, caprylic / capric triglyceride, and isononyl isononanoate.

[0028] Secondly, the present invention provides the use of a composition for preparing cosmetics that remove acne, fade acne scars, and repair skin damage.

[0029] Thirdly, the present invention provides an acne-repairing composition for preparing a water-based cosmetic, an emulsion-based cosmetic, a gel-based cosmetic, a patch-based cosmetic, an aerosol-based cosmetic, and a powder-based cosmetic.

[0030] In one embodiment of the present invention, the acne-repairing and repairing composition is used to prepare an acne-repairing and repairing lotion.

[0031] In one embodiment of the present invention, the acne-repairing lotion comprises the following components in parts by weight of the acne-repairing composition:

[0032] Azelaic acid 0.01-30 parts, bisabolol 0.01-2 parts, white willow bark extract 0.01-5 parts, Egyptian blue water lily extract 0.01-5 parts, kale extract 0.01-5 parts, and yarrow extract 0.1-5 parts; excipients: water 80-95 parts, PEG-100 stearate 0.1-1 parts, glyceryl stearate 0.1-1 parts, squalane 0.5-2 parts, isohexadecane 0.5-1 parts, carbomer 0.02-0.2 parts, xanthan gum 0.001-0.1 parts, butylene glycol 1-5 parts, glycerin 1-5 parts, and phenoxyethanol 0.5-0.8 parts.

[0033] In one embodiment of the present invention, the acne-repairing lotion comprises the following components in parts by weight of the acne-repairing composition:

[0034] Azelaic acid 0.1-20 parts, bisabolol 0.01-1.5 parts, white willow bark extract 0.1-4 parts, Egyptian blue water lily extract 0.1-3 parts, kale extract 0.1-3 parts, and yarrow extract 0.1-3 parts;

[0035] Excipients: 80-95 parts water, 0.1-1 part PEG-100 stearate, 0.1-1 part glyceryl stearate, 0.5-2 parts squalane, 0.5-1 part isohexadecane, 0.02-0.2 parts carbomer, 0.001-0.1 parts xanthan gum, 1-5 parts butylene glycol, 1-5 parts glycerin, 0.5-0.8 parts phenoxyethanol.

[0036] Compared with the prior art, the beneficial effects of the present invention are:

[0037] Firstly, the azelaic acid, bisabolol, 4-terpineol, salicylic acid, white willow bark extract, Egyptian blue water lily extract, kale leaf extract, and yarrow extract of this invention exhibit particularly prominent effects in acne treatment and the treatment of post-acne sequelae. Specifically, each component can act alone or synergistically to achieve the effects of acne treatment and the treatment of post-acne sequelae, namely post-acne erythema, post-acne pigmentation, and post-acne scars.

[0038] Azelaic acid is a skincare ingredient with antibacterial and skin-lightening properties. From an antibacterial perspective, azelaic acid can directly inhibit and kill bacteria on the skin surface and within hair follicles, thus suppressing acne-causing bacteria. From the perspective of treating post-acne sequelae, on the one hand, azelaic acid can inhibit the release of reactive oxygen species from neutrophils, inhibiting the formation of post-acne erythema (red acne marks) through anti-inflammatory and antioxidant effects. On the other hand, azelaic acid can inhibit dicarboxylic acid, a precursor to melanin synthesis, thereby inhibiting melanin production and improving post-acne pigmentation. Overall, azelaic acid can exert multiple synergistic effects, effectively addressing all stages of acne development. Bisabolol is a sesquiterpene alcohol natural product derived from plants, possessing broad-spectrum antibacterial, anti-inflammatory, and repairing properties. Bisabolol can reduce the release of leukotrienes LTB4 and interleukin-1L-1α induced by PMA, inhibit inflammation, and thus reduce the formation of post-acne erythema. Simultaneously, bisabolol has a repairing effect, promoting normal skin repair at the acne site and preventing post-acne scarring. 4-Terpineol has antibacterial and antioxidant functions, inhibiting both bacteria and fungi. Furthermore, it has significant antioxidant properties, helping the skin at the acne site repair rapidly and preventing post-acne scarring. Salicylic acid has keratolytic and anti-inflammatory effects; it dissolves keratin on the skin surface, unclogs pores, and allows sebum to be discharged normally, depriving Propionibacterium acnes of its basis for proliferation. Simultaneously, after acne subsides, salicylic acid exerts an anti-inflammatory effect, effectively alleviating post-acne erythema. The main active ingredient in white willow bark extract is salicin, which has antibacterial, anti-inflammatory, and repairing effects. On the one hand, its antibacterial and anti-inflammatory effects can inhibit inflammation caused by acne and effectively relieve post-acne erythema; on the other hand, salicin plays an important role in the production and maintenance of collagen, which can promote the normal repair of skin in acne-affected areas and reduce the formation of post-acne scars.

[0039] The main components of Egyptian blue water lily extract are amino acids and various flavonoids. Kale leaf extract mainly contains carotenoids such as lutein and is rich in flavonols, anthocyanins, and other flavonoid substances. Yarrow extract contains various organic acids and flavonoid glycosides. The applicant's research found that adding Egyptian blue water lily extract, kale leaf extract, and yarrow extract enables the composition to fade acne scars and repair skin damage while simultaneously having antibacterial, anti-inflammatory, and acne-reducing effects. The mechanism of action may be as follows: Firstly, the flavonoids in these extracts have a protective effect against cellular oxidative stress, delaying cell death caused by oxidative damage, thereby promoting normal skin repair after acne subsides and preventing post-acne erythema, pigmentation, and scarring caused by abnormal repair. Secondly, some flavonoids in the plant extracts have tyrosinase inhibitory activity, blocking melanin production and reducing post-acne pigmentation. Simultaneously, the small molecule amino acids in the plant extracts can penetrate the skin well, thus playing a certain role in repairing skin damage caused by acne and reducing post-inflammatory pigmentation.

[0040] Secondly, the composition of this invention has the effects of oil control and acne prevention: azelaic acid can competitively inhibit the enzymatic process of dihydrotestosterone production, reducing excessive skin oil induced by dihydrotestosterone, and salicylic acid also has the effect of regulating sebum secretion. Sebum is the basis for the reproduction of Propionibacterium acnes; by inhibiting the production of skin sebum, it can effectively prevent the further development of acne.

[0041] Secondly, the composition of the present invention has the effect of removing blackheads: blackhead sebum oxidation and small black dots formed by mixed deposited pigment particles, azelaic acid can reverse the degree of keratinization of hair follicles, and salicylic acid has a unclogging effect and can dissolve sebum, thereby enabling the composition to improve blackhead acne.

[0042] Secondly, the composition of this invention has a good skin brightening effect: glucose continuously combines with proteins to form advanced glycation end products (AGEs). Glycation leads to protein cross-linking, causing cells to lose their ability to divide. The skin gradually turns brownish-yellow and loses its elasticity. The white willow bark extract in the composition of this invention plays an important role in the production and maintenance of collagen. Collagen promotion can remove dullness from the skin and restore its whiteness. In addition, the applicant added Egyptian blue water lily extract, kale leaf extract, and yarrow extract to the composition. The composition can significantly improve pigmentation and restore normal skin color.

[0043] Finally, the composition of this invention has good moisturizing properties, is gentle and non-irritating, and has a light texture that is easy to apply and absorb. Most existing skincare compositions containing acids (such as azelaic acid and salicylic acid) are highly irritating. When the ingredient ratio is not carefully controlled, it can easily cause irritation and pain, and lead to moisture loss, resulting in tightness and peeling. The composition of this application, through the rational addition of natural ingredients and excipients, successfully solves the defects of the aforementioned acid-based compositions used in skincare products. Tests show that the product not only has the above-mentioned multiple effects, but also has a refreshing texture that does not cause tightness or even dehydration, and also provides moisturizing benefits.

[0044] Compared to current antibacterial compositions on the market that have relatively simple ingredients and only focus on antibacterial and soothing effects, this invention provides a mild, non-irritating, lightweight, easy-to-apply and absorb acne-removing composition through the preparation of the above composition. This composition not only removes acne but also reduces post-acne erythema, treats post-acne pigmentation, and alleviates post-acne scarring. It also removes blackheads and brightens skin tone, effectively addressing post-acne sequelae and providing multi-effect skincare, thus achieving comprehensive treatment throughout the acne cycle from onset to resolution. Attached Figure Description

[0045] Figure 1 Photos of the subject's acne before using the composition serum (prepared according to Preparation Example 1) (left image), and photos of facial acne after 2 months of use (right image). Detailed Implementation

[0046] The present invention will be further described in detail below with reference to specific embodiments. The following embodiments are not intended to limit the present invention, but only to illustrate the present invention. Unless otherwise specified, the experimental methods used in the following embodiments are generally performed under conventional conditions. Unless otherwise specified, the materials and reagents used in the following embodiments are commercially available.

[0047] Preparation Example 1

[0048] The cosmetic composition described in this embodiment is formulated into a water-based cosmetic, specifically an anti-acne repair essence, the formula of which is shown in Table 1.

[0049]

[0050] The preparation method of the aqueous cosmetic product described in this embodiment is carried out according to the following steps:

[0051] 1. Add phenoxyethanol and azelaic acid to butanediol and dissolve thoroughly;

[0052] 2. Add deionized water, heat to 75 degrees Celsius, then cool to 45 degrees Celsius;

[0053] 3. Add the remaining ingredients and dissolve thoroughly.

[0054] Test case

[0055] The following experimental tests were conducted on the acne-repairing composition (containing: azelaic acid 0.01-3 parts, bisabolol 0.01-0.5 parts, white willow bark extract 0.1-2 parts, Egyptian blue water lily extract 0.1-2 parts, kale leaf extract 0.1-2 parts, and yarrow extract 0.1-5 parts, with purified water to a final volume of 100 parts):

[0056] Test subject:

[0057] Thirty healthy Chinese male / female subjects aged 18-50 years were randomly selected. They had oily skin, mild to moderate acne on both sides of their face, and were assessed by doctors as having acne grade 2-3, visible blackheads on both sides of the nose, dry facial skin, poor barrier function, and some redness.

[0058] Test method:

[0059] A before-and-after comparison method was used to compare various indicators before using the test product, after using the test product for 14 consecutive days, and after using the test product for 28 consecutive days. The effectiveness of the product was determined by comparing the evaluation results before and after use.

[0060] Measurement indicators:

[0061] The following indicators were measured on the subjects' skin:

[0062] 1) Total score of skin lesions across the entire face;

[0063] 2) Visia-CR redness value at acne sites and the percentage of Visia-CR red area on the entire face;

[0064] 3) Melanin content in acne areas;

[0065] 4) Facial oil content and percentage of Visia-CR porphyrin area on the entire face;

[0066] 5) Transepidermal water loss and moisture content of the stratum corneum in the cheek area;

[0067] 6) Percentage of pore area covered by Visia-CR on the entire face;

[0068] 7) Visia-CR skin color L value and Visia-CR skin color ITA value for the entire face;

[0069] 8) The number of blackheads on both sides of the nose;

[0070] 9) Subject self-assessment.

[0071] The test results are as follows:

[0072] Table 1. Total Skin Lesion Index (IGA) for the Entire Face

[0073]

[0074] Acne is characterized by polymorphic skin lesions on the face, such as comedones, papules, pustules, and nodules. Therefore, the total score of skin lesions on the whole face can well reflect the effect of the composition in treating acne.

[0075] As can be seen from Table 1 above, the area of ​​facial lesions was significantly reduced after using the anti-acne repair composition prepared using this test example, reflecting that the composition has a good therapeutic effect in the early stage of acne.

[0076] Table 2 Visia-CR redness values ​​at acne sites and percentage of Visia-CR red area on the entire face

[0077]

[0078]

[0079] As can be seen from Table 2 above, the anti-acne repair composition prepared using this test example not only improves erythema at acne sites and effectively alleviates the formation of red acne marks, but also has a certain soothing effect on the whole face and is very effective for facial skin inflammation and redness.

[0080] Table 3. Melanin content in acne lesions

[0081]

[0082] As can be seen from Table 3 above, the anti-acne repair composition prepared using this test example can reduce melanin deposition in acne areas and prevent the formation of dark acne marks.

[0083] Table 4. Skin oil content on cheeks and percentage of Visia-CR porphyrin area on the entire face.

[0084]

[0085] Oil is the foundation for the proliferation of acne-causing bacteria; high levels of oil in the skin make it more prone to acne. Porphyrins are metabolic products of some bacteria that live in hair follicles, and the percentage of porphyrin area can reflect the growth and reproduction of acne-causing bacteria.

[0086] As shown in Table 4 above, the anti-acne repair composition prepared using this test example has a good oil-controlling effect on the skin and a significant killing effect on acne bacteria. It not only has a positive effect on the treatment of acne but also effectively prevents the further development of acne.

[0087] Table 5. Transepidermal water loss and stratum corneum moisture content in the cheek area.

[0088]

[0089] As can be seen from Table 5 above, the anti-acne repair composition prepared using this test example not only does not produce a feeling of tightness or dehydration, but also significantly reduces transepidermal water loss on the cheeks and increases the moisture content of the stratum corneum, thus playing a very good moisturizing role.

[0090] Table 6. Percentage of Visia-CR pore area on the entire face

[0091]

[0092] As can be seen from Table 6 above, the anti-acne repair composition prepared using this test example has a certain shrinking effect on the skin's pores, which helps to alleviate the sequelae of enlarged pores caused by acne and prevent the further development of acne.

[0093] Table 7. Visia-CR Skin Color L Value and Visia-CR Skin Color ITA Value for the Entire Face

[0094]

[0095] Both the L value and ITA value of Visia-CR reflect the brightness of the skin. The ITA value is a function related to the L value. The higher the ITA value, the lower the yellowness and the brighter the skin.

[0096] As can be seen from Table 7 above, the anti-acne repair composition prepared using this test example has a good skin brightening effect.

[0097] Table 8: Number of blackheads on both sides of the nose

[0098]

[0099] As can be seen from Table 8 above, the anti-acne repair composition prepared using this test example can significantly improve blackhead conditions.

[0100] Table 9. Subjects' Self-Assessment

[0101] A questionnaire survey was conducted on the test participants. In the questionnaire, for each question, 1 point was "strongly disagree", 2 points was "disagree", 3 points was "neutral", 4 points was "agree", and 5 points was "strongly agree".

[0102] Table 9 shows the percentage of people who selected 4 points for "agree" and 5 points for "strongly agree" regarding the relevant questionnaire questions.

[0103]

[0104] As can be seen from Table 9 above, the composition is mild and non-irritating, with a light texture that is easy to apply and absorb. Subjects also subjectively recognized the product's oil-controlling effect and were satisfied with the composition's various effects, such as acne removal, acne scar removal, and moisturizing.

[0105] As can be seen, the acne treatment of this invention, when containing azelaic acid, bisabolol, white willow bark extract, Egyptian blue water lily extract, kale leaf extract, and yarrow extract, can simultaneously reduce post-acne erythema, treat post-acne pigmentation, and also has the effects of removing blackheads and brightening skin tone. At the same time, this composition has good moisturizing effects, is gentle and non-irritating, has a light texture, is easy to apply and absorb, and can effectively achieve comprehensive treatment throughout the acne cycle from onset to resolution.

[0106] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, and is not intended to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions made by those skilled in the art to the technical solution of the present invention do not depart from the essence and scope of the technical solution of the present invention.

Claims

1. A cosmetic composition for external use, characterized in that, The composition comprises, by weight parts: Azelaic acid 1 part, bisabolol 0.5 parts, white willow bark extract 2 parts, Egyptian blue water lily extract 2 parts, kale extract 2 parts, yarrow extract 2 parts, and betaine 2 parts.

2. The cosmetic composition according to claim 1, characterized in that, The composition may also contain other excipients.

3. The cosmetic composition according to claim 2, characterized in that, The excipients may be selected from one or more of the following: humectants, emulsifiers, foaming agents, pH adjusters, preservatives, and thickeners.

4. The cosmetic composition according to claim 3, characterized in that, The moisturizer is selected from one or more of the following: glycerin, propylene glycol, 1,3-butanediol, 1,2-hexanediol, pentanediol, dipropylene glycol, trehalose, panthenol, nicotinamide, maltose, β-glucan, sodium lactate, polyvinylpyrrolidone, polyquaternium-51, sorbitol, caprylyl glycol, ethylhexylglycerin, PEG-200, PEG-400, and glyceryl polyether-26. The emulsifier is selected from cetearyl alcohol, cetearyl alcohol polyether-21, glyceryl stearate, PEG-100 stearate, PEG-15 glyceryl stearate, PEG-20 glyceryl stearate, PEG-30 glyceryl stearate, PEG-40 glyceryl stearate, polysorbate-20, polysorbate-40, polysorbate-60, polysorbate-80, polysorbate-85, and polyglycerol-10. Isostearate, polyglycerol-10 disostearate, polyglycerol-10 myristate, polyglycerol-10 isostearate, polyglycerol-10 laurate, polyglycerol-10 stearate, polyglycerol-10 oleate, polyglycerol-5 stearate, behenyl ether-10, behenyl ether-20, behenyl ether-25, behenyl ether-30, cetearyl glucoside, and sorbitan olive oil ester, or one or more thereof; The foaming agent is selected from one or more of the following: cocamidopropyl betaine, sodium cocoyl glycinate, sodium cocoaminopropionate, sodium cocoyl hydroxyethyl sulfonate, sodium laureth sulfate, ammonium laureth sulfate, sodium laureth sulfate, cocamidopropyl hydroxysulfonate betaine, sodium lauroyl sarcosinate, potassium laurate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium laureth-6 carboxylate, laureth-16, decyl glucoside, lauryl hydroxysulfonate betaine, and disodium cocoamphodiacetate. The pH adjuster is selected from one or more of citric acid, sodium citrate, sodium hydroxide, and sodium potassium dehydroacetate; The preservative is selected from one or more of phenoxyethanol, p-hydroxyacetophenone, ethylhexylglycerin, caprylyl glycol, capryloyl hydroxamic acid, 1,2-hexanediol and benzoic acid; The thickener is selected from one or more of the following: carbomer, acrylic acid (type) / C10-30 alkanol acrylate crosspolymer, xanthan gum, Sphingomonas fermentation extract, hydroxyethyl cellulose, and ammonium acryloyl dimethyl taurate / VP copolymer.

5. The use of the cosmetic composition according to any one of claims 1-4 in the preparation of cosmetics for treating acne, fading acne scars, and repairing skin damage.

6. The use of the cosmetic composition according to any one of claims 1-4, characterized in that, The composition is used to prepare aqueous cosmetics, emulsion cosmetics, gel cosmetics, patch cosmetics, aerosol cosmetics and powder cosmetics.

7. An acne-removing and repairing essence, characterized in that, The acne-repairing composition comprises the following components by weight: Azelaic acid 0.01-3 parts, bisabolol 0.01-0.5 parts, white willow bark extract 0.1-2 parts, Egyptian blue water lily extract 0.1-2 parts, kale leaf extract 0.1-2 parts, and yarrow extract 0.1-5 parts; Excipients: 80-98 parts water, 1-5 parts betaine, 1-5 parts 1,3-butanediol, 0.5-1 part phenoxyethanol.

8. An acne-removing facial cleansing mousse, characterized in that, The acne-repairing composition comprises the following components by weight: Azelaic acid 0.1-2 parts, bisabolol 0.1-0.5 parts, white willow bark extract 0.1-2 parts, Egyptian blue water lily extract 0.1-2 parts, kale leaf extract 0.1-2 parts, and yarrow extract 0.1-2 parts; Excipients: 35-83 parts water, 10-30 parts sodium cocoyl aminopropionate, 2-10 parts decyl glucoside, 2-10 parts sodium lauryl ether-6 carboxylate, 0.1-1 part citric acid, 1-5 parts betaine, 1-5 parts 1,3-butanediol, 0.5-1 part phenoxyethanol.

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