Drug-delivering hydrogel contact lens microneedle and preparation method thereof

CN117045582BActive Publication Date: 2026-07-24JINLING INST OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINLING INST OF TECH
Filing Date
2023-08-16
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

In current ophthalmic disease treatments, local drug delivery methods have low bioavailability. Traditional ocular drug delivery methods have low bioavailability and can damage normal tissues. Intracavitary injection carries the risk of infection and is difficult to effectively deliver large molecule drugs.

Method used

A drug-delivering hydrogel corneal contact lens microneedle was designed. The microneedle was prepared on the hydrogel corneal contact lens, and the microneedle tip was formed using materials such as chitosan and sodium periodate. The hydrogel was then combined with HEMA and NVP to achieve effective drug delivery and sustained release.

Benefits of technology

It improves the delivery effect of macromolecular drugs, reduces irritation to normal tissues, has good light transmittance and sustained-release properties, is comfortable to wear, and has high safety.

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Abstract

The application provides a hydrogel contact lens microneedle capable of delivering drugs, and a preparation method thereof is as follows: chitosan powder is dissolved in an acetic acid solution to prepare a chitosan solution, the chitosan solution is filtered and dialyzed, a drug is added and stirred to dissolve, then dopamine hydrochloride and sodium periodate solution are added in sequence and mixed uniformly, the mixture is placed at room temperature for a period of time, and the drug-containing microneedle tip is prepared by introducing the mixture into a microneedle mold; hydroxyethyl methacrylate and N-vinyl pyrrolidone are mixed and shaken uniformly, an initiator is added, and the mixture is stirred uniformly; the mixture is added dropwise into the microneedle mold including the drug-containing microneedle tip, a cover glass is added to seal the mold, the mold is placed in a constant-temperature drying box for a period of time, and the hydrogel contact lens microneedle is obtained after stripping. In the hydrogel contact lens microneedle, the drug is embedded in the microneedle, the contact and stimulation of the drug on normal tissues can be reduced, the hydrogel contact lens microneedle has good sustained-release effect, and effective delivery of the drug can be achieved.
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