Oral care composition

Abstract

An oral care composition is disclosed, comprising 0.01 to 10% by weight of a deposited polymer and a polyhydroxy fatty acid amide surfactant of formula (I); wherein R 1 It is a C1-C4 alkyl or hydroxyl-substituted C1-C4 alkyl; R 2 It is a straight-chain or branched, saturated or unsaturated hydrocarbon chain having 15 to 21 carbon atoms, and a beneficial agent selected from optical agents, antimicrobial agents and mixtures thereof; wherein the deposited polymers include xanthan gum, sodium alginate, pectin, modified starch, gelatin, carrageenan, gellan gum, fenugreek gum, konjac gum, tragacanth gum, arabic gum, γ-polyglutamic acid, sodium heparin, copolymers of methyl vinyl ether and maleic anhydride, polyacrylic acid, polystyrene sulfonate, deoxyribonucleic acid, poly(allylamine), locust bean gum, guar gum, polyglycolic acid, polylactic acid, poly(glycolic acid-co-lactic acid), chitosan, humic acid, phytic acid, derivatives thereof or mixtures thereof:

Description

Technical Field

[0001] This invention relates to oral care compositions, such as toothpaste, powders, gums, mouthwashes, etc. In particular, this invention relates to oral care compositions comprising beneficial agents and deposition aids for the beneficial agents. This invention also relates to the use of such compositions for teeth whitening and / or improving personal oral hygiene. Background Technology

[0002] The enamel layer of teeth is naturally opaque white or slightly grayish-white. However, this enamel layer can be stained or discolored. Many products we consume have a negative impact on our teeth and oral cavity. Many substances can stain or reduce the whiteness of teeth, especially certain foods, tobacco products, and fluids such as tea and coffee. These staining and discoloring substances can usually penetrate the enamel layer. This problem occurs gradually over many years, causing noticeable discoloration of the enamel.

[0003] Consumers have always had a strong desire for healthy, white teeth. Beneficial agents, such as optical agents and antimicrobial agents, are often incorporated into oral care products to provide benefits such as whitening and better oral hygiene. However, many oral care products fail to provide sufficient deposits of these beneficial agents on the teeth. During routine oral hygiene activities such as brushing, these beneficial agents are simply rinsed away, resulting in little or no beneficial effect.

[0004] Therefore, there is a ongoing need for an oral care composition that provides improved deposition of beneficial agents on teeth to maximize the effectiveness of such agents.

[0005] WO 2020 / 234811A1 (3M Innovative Properties Company) discloses a composition comprising 0.2% to 3% by weight of arginine, glycine, or combinations thereof based on the total weight of the composition; and one or more surfactants of formula I: HOCH2-(CHOH) based on the total weight of the composition. n -CH2NR 1 R 2 (I); where R 1 and R 2 Independently selected from the following groups: hydrogen atom, alkyl group, C(O)R 3 and SO2R 4 ;where R 3 and R 4 It is independently selected from the group consisting of alkyl, aryl, and aralkyl; where n is an integer from about 2 to about 5.

[0006] WO 2020 / 091805A1 (Colgate-Palmolive Company) discloses an oral care composition comprising an oral-acceptable carrier and one or more surfactants. The one or more surfactants may include N-alkyl-N-acylglucosamine.

[0007] WO 2019 / 123171A1 (3M Innovative Properties Company) discloses a composition comprising 0.1 wt% to 8 wt% of one or more of the formula HOCH2-(CHOH) based on the total weight of the composition. n -CH2NR 1 R 2 The compound in which R 1 and R 2 Independently selected from the following groups: hydrogen atom, alkyl group, C(O)R 3 and SO2R 4 ;where R 3 and R 4 The composition is independently selected from the group consisting of alkyl, aryl, and aralkyl; wherein n is an integer from about 2 to about 5; one or more vegetable oils from 5% to 95% by weight of the total weight of the composition; water from 5% to 80% by weight of the total weight of the composition; and one or more nonionic aromatic phenolic preservatives from 0.01% to 1% by weight of the total weight of the composition, wherein the pH of the composition is from 4.5 to 9.5, the composition is an emulsion, and the composition is edible. Summary of the Invention

[0008] In a first aspect, the present invention relates to an oral care composition comprising:

[0009] (a) 0.01 to 10% by weight of the deposited polymer;

[0010] (b) Polyhydroxy fatty acid amide surfactants of formula (I):

[0011]

[0012] Where R 1 It is a C1-C4 alkyl or hydroxylated C1-C4 alkyl; R 2 It is a straight-chain or branched, saturated or unsaturated hydrocarbon chain with 15 to 21 carbon atoms; and

[0013] (c) Beneficial agents selected from optical agents, antimicrobial agents and mixtures thereof;

[0014] The deposited polymers include xanthan gum, sodium alginate, pectin, modified starch, gelatin, carrageenan, gellan gum, fenugreek gum, konjac gum, tragacanth gum, karaga gum, γ-polyglutamic acid, sodium heparin, copolymers of methyl vinyl ether and maleic anhydride, polyacrylic acid, polystyrene sulfonate, deoxyribonucleic acid, poly(allylamine), locust bean gum, guar gum, polyglycolic acid, polylactic acid, poly(glycolic acid-co-lactic acid), chitosan, humic acid, phytic acid, and their derivatives or mixtures.

[0015] In a second aspect, the present invention relates to a packaged oral care product comprising the oral care composition of the first aspect of the present invention.

[0016] In a third aspect, the present invention relates to a method for whitening teeth and / or improving personal oral hygiene, comprising the step of applying a composition of any embodiment of the first aspect to at least one surface of personal teeth.

[0017] All other aspects of the invention will become more apparent upon consideration of the following detailed description and embodiments. Invention Details

[0019] Except where explicitly stated in the examples or elsewhere, all figures in this specification indicating the amount of material or the conditions of reaction, the physical properties of the material and / or its use may optionally be understood to be modified by the word “about”.

[0020] Unless otherwise specified, all quantities are by weight of the final oral care composition. It should be noted that when specifying any numerical range, any particular upper limit can be associated with any particular lower limit.

[0021] To avoid ambiguity, the word "comprising" is intended to mean "including," but not necessarily "consisting of" or "composed of." In other words, the steps or options listed do not need to be exhaustive.

[0022] The disclosure of the present invention as found herein should be considered to cover all embodiments in which multiple dependencies are found in the claims, without regard to the fact that no multiple dependencies or redundancies are found in the claims.

[0023] Where features are disclosed with respect to a particular aspect of the invention (e.g., the compositions of the invention), such disclosure should also be considered to be applicable to any other aspect of the invention (e.g., the methods of the invention) with necessary modifications.

[0024] The oral care composition of the present invention comprises a deposition polymer. As used herein, the term "deposition polymer" refers to a polymer that facilitates the deposition of beneficial agents from the continuous phase of the composition onto the tooth surface during use of the composition. Use of the composition in the context of this invention generally includes applying the composition to the oral cavity, followed by brushing and / or rinsing. The deposition polymer enhances the deposition of beneficial agents onto the tooth surface, thereby enhancing the performance of the composition. The deposition polymer suitable for use in the present invention can be natural or synthetically derived.

[0025] The deposited polymers used in this invention include xanthan gum, sodium alginate, pectin, modified starch, gelatin, carrageenan, gellan gum, fenugreek gum, konjac gum, tragacanth gum, guilarin gum, γ-polyglutamic acid, sodium heparin, copolymers of methyl vinyl ether and maleic anhydride, polyacrylic acid, polystyrene sulfonate, deoxyribonucleic acid, poly(allylamine), locust bean gum, guar gum, polyglycolic acid, polylactic acid, poly(glycolic acid-co-lactic acid), chitosan, humic acid, phytic acid, derivatives thereof, or mixtures thereof. Preferably, the deposited polymers include xanthan gum, sodium alginate, pectin, modified starch, gelatin, carrageenan, gellan gum, fenugreek gum, konjac gum, tragacanth gum, γ-polyglutamic acid, phytic acid, derivatives thereof, or mixtures thereof.

[0026] Preferably, the deposited polymer is xanthan gum and / or its derivatives.

[0027] Xanthan gum is an extracellular polysaccharide secreted by the microorganism Xanthomonas campestris. It consists of a linear (1,4) linked β-D-glucose backbone (like cellulose), with a trisaccharide side chain on each of the other glucose molecules at C-3. This side chain comprises a (1,4) linking to a terminal mannose unit and a (1,2) linking to a glucuronic acid residue that is linked to a second mannose unit on the backbone. Approximately 50% of the terminal mannose residues are acetylated, while the non-terminal residues typically have an acetyl group at C-6.

[0028] The structure of xanthan gum is given below:

[0029]

[0030] Wherein n ranges from 10 to 10,000, preferably from 100 to 8,000, more preferably from 500 to 5,000, and most preferably from 1,000 to 3,000.

[0031] Xanthan gum derivatives can be prepared by etherification, esterification, acetalization, amidation, or oxidation of non-derivative xanthan gum. Preferred xanthan gum derivatives are prepared by reacting non-derivative gum with a quaternary ammonium compound in an amount equal to or greater than the stoichiometric amount required for complete derivatization. The quaternary ammonium compound preferably has a single alkyl or alkenyl substituent containing 13-24 carbon atoms, and / or two alkyl or alkenyl substituents, each having 12-24 carbon atoms. Most preferably, the quaternary ammonium compound is alkyl dimethyl benzyl ammonium chloride having an alkyl group containing 13-24 carbon atoms.

[0032] The oral care composition contains 0.01 to 10%, preferably 0.02 to 5%, more preferably 0.05 to 3%, and most preferably 0.05 to 2% of deposited polymer, based on the total weight of the oral care composition and including all ranges contained therein.

[0033] The polyhydroxy fatty acid amide surfactants applicable to this invention are nonionic surfactants represented by general formula (I):

[0034]

[0035] Where R 1 It is a C1-C4 alkyl or hydroxylated C1-C4 alkyl; R 2 It is a straight or branched, saturated or unsaturated hydrocarbon chain with 15 to 21 carbon atoms.

[0036] R 1 Preferably, it is a C1-C2 alkyl group, more preferably a methyl group.

[0037] R 2 Preferably, it is an alkyl, alkenyl, aryl, or aralkyl group having 15 to 21 carbon atoms, more preferably 15 to 19 carbon atoms, and most preferably 16 to 19 carbon atoms.

[0038] Preferably, R 1 For methyl, R 2 It is an alkyl group having 15 to 21 carbon atoms, more preferably 15 to 19 carbon atoms, and most preferably 16 to 19 carbon atoms.

[0039] Preferably, the polyhydroxy fatty acid amide surfactant comprises at least 60% by weight of the following polyhydroxy fatty acid amide, wherein R 1 For methyl, R 2 C 17 Alkyl groups, more preferably 70 to 100%, more preferably 80 to 100%, and most preferably 90 to 100%, based on the total weight of the polyhydroxy fatty acid amide.

[0040] The preferred surfactants are the following polyhydroxy fatty acid amides, wherein R 1 For methyl, R2 C 17 alkyl.

[0041] The compositions of the present invention may additionally contain a small portion of polyhydroxy fatty acid amides having short hydrocarbon chains, particularly wherein R 2 For C1-C4, C5, C7, C9, C 11 C 13 Alkyl groups, or C2, C3, C5, C7, C9, C 11 C 13 Alkenyl group.

[0042] An example of a polyhydroxy fatty acid amide surfactant suitable for use in this invention is commercially available from Clariant International Ltd. Sense's sunflower-oyl methyl glucamide.

[0043] The oral care composition typically contains 0.01 to 10%, more preferably 0.1 to 8%, and most preferably 0.5 to 5% of the polyhydroxy fatty acid amide, based on the total weight of the oral care composition, and including all ranges contained therein.

[0044] As used herein, a beneficial agent refers to an active substance that is typically delivered to human teeth and / or oral cavity (including gums) to enhance or improve the properties of these dental tissues. The only limitation regarding the beneficial agents that can be used in this invention is their suitability for oral use.

[0045] Beneficial agents typically include, for example, optical agents, biomineralizing agents, adsorbents, antimicrobial agents, gingival health agents, desensitizing agents, anti-calculus agents, preservatives, or mixtures thereof. Preferably, the beneficial agent is selected from optical agents, antimicrobial agents, and mixtures thereof.

[0046] The optical agent can be selected from one or more of whitening agents and pearlescent agents. When the optical agent is a whitening agent, it is preferred that the whitening agent is a dye or pigment or a combination of both. The pigment according to the invention is a shade / material that is insoluble in the relevant medium at a relevant temperature. This is in contrast to soluble dyes. The term "relevant medium" as used herein refers to human saliva at oral temperature during brushing, i.e., at most 37°C, i.e., the liquid medium in which the composition is used. The relevant medium can also be water, with a relevant temperature of 25°C. Preferred pigments or dyes used in the invention are purple or blue with a hue angle h of 220 to 320 degrees, preferably 250 to 290 degrees, in the CIELAB system. When the whitening agent is a pigment, it is preferred that the pigment is one or more of pigment blue 1 to pigment blue 83 and pigment violet 1 to pigment violet 56 listed in the Colour Index International. Other suitable pigments are ultramarine blue and ultramarine violet. Although the preferred pigment is blue or purple, the same effect can be achieved by mixing pigments outside this hue angle range. For example, this hue angle can also be obtained by mixing red and green-blue pigments to produce a blue or purple shaded pigment. Particularly preferred is that the pigment is a blue pigment. A preferred class of blue pigments suitable for the present invention are organic blue pigments, such as phthalocyanine blue pigments. Particularly preferred is that the pigment is a phthalocyanine blue pigment selected from α-copper phthalocyanine pigment blue 15, pigment blue 15:1, pigment blue 15:2, pigment blue 15:3, pigment blue 15:4, pigment blue 15:6, and mixtures thereof, more preferably pigment blue 15, pigment blue 15:1, pigment blue 15:2, and mixtures thereof. The most preferred pigment is pigment blue 15:1. A commercially available example is Cosmenyl Blue A4R from Clariant. When the whitening agent is a dye, the dye is preferably a blue dye, more preferably FD&C Blue 1, Patent Blue V, or Gardenia Blue.

[0047] In another preferred embodiment, the brightener is a particulate brightener with a refractive index of 1.9 to 4.0. The refractive index refers to a value at a temperature of 25°C and a wavelength of 589 nm. Suitable materials providing such a high refractive index are metal compounds, preferably compounds in which the metal is selected from zinc (Zn), titanium (Ti), zirconium (Zr), or mixtures thereof. Preferably, the metal compound is (or at least contains) a metal oxide such as titanium dioxide (TiO2), zinc oxide (ZnO), zirconium dioxide (ZrO2), or mixtures thereof. Preferably, the particulate brightener is a composite particle. As used herein, the term "composite particle" refers to particles comprising a first component core and a second component coating, wherein the core and coating are composed of different materials. Composite particles comprise a first component core and a second component coating. Particularly suitable core materials are metal compounds, preferably compounds in which the metal is selected from zinc (Zn), titanium (Ti), zirconium (Zr), or mixtures thereof. Preferably, the metal compound is (or at least comprises) a metal oxide, such as titanium dioxide (TiO2), zinc oxide (ZnO), zirconium dioxide (ZrO2), or mixtures thereof. The second component coating comprises a material suitable for adhesion to enamel, dentin, or both. Typically, the coating material comprises elemental calcium, and optionally other metallic elements such as potassium, sodium, aluminum, magnesium, and mixtures thereof, thereby providing such optional metals, for example, as sulfates, lactates, oxides, carbonates, or silicates. Optionally, the coating material may be alumina or silica. In a preferred embodiment, the second component coating may comprise, for example, calcium phosphate, calcium gluconate, calcium oxide, calcium lactate, calcium carbonate, calcium hydroxide, calcium sulfate, calcium carboxymethyl cellulose, calcium alginate, calcium salts of citric acid, calcium silicate, mixtures thereof, etc. Calcium silicate is particularly preferred. In a particularly preferred embodiment, the particulate brightener is titanium dioxide coated with calcium silicate.

[0048] In another preferred embodiment, the optical agent is a pearlescent agent. As used herein, the term "pearlescent agent" refers to a reagent in particulate form that reflects and partially transmits incident light. Suitable pearlescent agents for use in this invention include mica, bismuth oxychloride, or mixtures thereof. Preferably, the pearlescent agent is formed by coating one or more metal oxide layers onto a natural or synthetic mica sheet. Examples of suitable mica include, for example, muscovite, phlogopite, fluorophlogopite, biotite, or mixtures thereof. Examples of suitable metal oxides include, for example, TiO2, Fe2O3, TiFe2O5, Fe3O4, Cr2O3, Al2O3, SiO2, ZrO2, ZnO, SnO2, CoO, Co3O4, VO2, V2O3, Sn(Sb)O2, low-valent titanium oxides, or mixtures thereof. A preferred example of a pearlescent agent is mica coated with TiO2.

[0049] The antimicrobial agent may be selected from one or more of the following: wherein the metal is selected from metal compounds of zinc, copper, silver or mixtures thereof, triclosan, triclosan monophosphate, triclocarban, curcumin, quaternary ammonium compounds, biguanides, and long-chain tertiary amines, preferably zinc compounds, including zinc oxide, zinc chloride, zinc acetate, zinc ascorbate, zinc sulfate, zinc nitrate, zinc citrate, zinc lactate, zinc peroxide, zinc fluoride, zinc ammonium sulfate, zinc bromide, zinc iodide, zinc gluconate, zinc tartrate, zinc succinate, zinc formate, zinc phenolsulfonate, zinc salicylate, zinc glycerophosphate, or mixtures thereof. Zinc citrate is particularly preferred.

[0050] Preferred beneficial agents are optical agents selected from pigments, dyes, mica, TiO2-coated mica, titanium dioxide, calcium silicate-coated titanium dioxide, and mixtures thereof. More preferred beneficial agents are phthalocyanine blue pigments selected from α-copper phthalocyanine pigment blue 15, pigment blue 15:1, pigment blue 15:2, and mixtures thereof. Pigment blue 15:1 is particularly preferred.

[0051] The preferred active ingredient is a zinc compound selected from zinc oxide, zinc chloride, zinc acetate, zinc ascorbate, zinc sulfate, zinc nitrate, zinc citrate, zinc lactate, zinc peroxide, zinc fluoride, zinc ammonium sulfate, zinc bromide, zinc iodide, zinc gluconate, zinc tartrate, zinc succinate, zinc formate, zinc phenolsulfonate, zinc salicylate, zinc glycerophosphate, and mixtures thereof. Zinc citrate is particularly preferred.

[0052] The oral care composition of the present invention may contain a single beneficial agent or a mixture of two or more beneficial agents. Typically, the beneficial agent is present in an amount of 0.01 to 60%, more preferably 0.05 to 40%, and most preferably 0.1 to 30% by weight of the total oral care composition, and includes all ranges contained therein.

[0053] When the beneficial agent is a pigment, the pigment is preferably present at a level of 0.001 to 1%, more preferably 0.01 to 0.5%, and most preferably 0.02 to 0.2% of the weight of the oral care composition, based on the total weight of the oral care composition, and including all ranges contained therein.

[0054] Preferably, the pH of the oral care composition is from 4.0 to 10.0, more preferably from 5.0 to 9.0, and most preferably from 5.5 to 8.0. The pH of the oral care composition is measured when 5 parts by weight of the composition are uniformly dispersed and / or dissolved in 20 parts by weight of pure water at 25°C. Specifically, the pH can be measured by manually mixing 5g of the oral care composition with 20mL of water for 30 seconds, and then immediately testing the pH with an indicator or pH meter.

[0055] Oral care compositions may contain surfactants other than polyhydroxy fatty acid amides. Suitable surfactants include anionic surfactants such as sodium, magnesium, ammonium, or ethanolamine salts of the following acids: C8 to C18 alkyl sulfates (e.g., sodium dodecyl sulfate), C8 to C18 alkyl sulfosuccinic acids (e.g., sodium dioctyl sulfosuccinate), C8 to C18 alkyl sulfoacetic acids (e.g., sodium lauryl sulfoacetate), C8 to C18 alkyl sarcosines (e.g., sodium lauryl sarcosine), C8 to C18 alkyl phosphoric acids (which may optionally contain up to 10 ethylene oxide and / or propylene oxide units), and sulfated monoglycerides. Other suitable surfactants include nonionic surfactants such as polyethoxylated fatty acid dehydrated sorbitol esters, ethoxylated fatty acids, esters of polyethylene glycol, ethoxylated monoglycerides and diglycerides of fatty acids, and ethylene oxide / propylene oxide block polymers. Other suitable surfactants include amphoteric surfactants such as betaine or sulfobetaine. Mixtures of any of the above materials may also be used. More preferably, the surfactant comprises or is an anionic surfactant. Preferred anionic surfactants are sodium dodecyl sulfate and / or sodium dodecylbenzene sulfonate. Most preferred surfactants are sodium dodecyl sulfate, sodium cocosulfate, cocamidopropyl betaine, sodium methyl cocoyl taurate, or mixtures thereof.

[0056] When the oral care composition includes a surfactant in addition to a polyhydroxy fatty acid amide, the surfactant is typically present at a level of 0.01 to 7%, more preferably 0.1 to 7%, and most preferably 0.5 to 5% by weight of the composition, based on the total weight of the oral care composition and including all ranges contained therein.

[0057] The oral care compositions of the present invention may contain a physiologically acceptable carrier. Water is the most commonly used carrier in the present invention. The carrier may further contain at least a thickener, a wetting agent, or a combination thereof.

[0058] In addition to deposited polymers included in oral care compositions, thickeners may also be used in this invention, and the range of thickeners is limited to those that can be added to compositions suitable for oral use. Exemplary examples of types of thickeners that can be used in this invention include sodium carboxymethyl cellulose (SCMC), hydroxyethyl cellulose, methyl cellulose, ethyl cellulose, silica-based thickeners including silica aerogels, magnesium aluminum silicate (e.g., Veegum), and mixtures thereof.

[0059] Sodium carboxymethyl cellulose is generally preferred. Copolymers included in the composition can also act as thickeners.

[0060] In a particularly preferred embodiment, the sodium carboxymethyl cellulose (SCMC) used is SCMC 9H. It has been described as a sodium salt of a cellulose derivative having a carboxymethyl group bound to a hydroxyl group of a pyranose skeletal monomer, and is identified by CAS number 9004-32-4. This sodium carboxymethyl cellulose is available from suppliers such as Alfa Chem.

[0061] The thickener typically comprises 0.01 to about 10% by weight of the oral care composition, more preferably 0.1 to 9% by weight, and most preferably 0.1 to 5% by weight, based on the total weight of the composition and including all ranges contained therein.

[0062] Suitable humectants are preferably used in the oral care compositions of the present invention, and they include, for example, glycerin, sorbitol, propylene glycol, dipropylene glycol, diglycerol, triacetyl, mineral oil, polyethylene glycol (preferably PEG-400), alkane diols such as butanediol and hexanediol, ethanol, pentanediol, or mixtures thereof. Glycerin, polyethylene glycol, sorbitol, or mixtures thereof are preferred humectants.

[0063] The carrier is typically present at a level of 10 to 90% by weight, more preferably 25 to 80% by weight, and most preferably 30 to 70% by weight of the oral care composition, based on the total weight of the composition, and including all ranges contained therein.

[0064] In addition to the beneficial agents contained in the composition, the oral care compositions of the present invention may also contain a variety of other ingredients that are common in the art and are used to enhance physical properties and performance. These ingredients include preservatives, pH adjusters, sweeteners, abrasive particles, buffers and salts for buffering the pH and ionic strength of the composition, and mixtures thereof. These ingredients generally and collectively constitute less than 20% by weight of the composition, and preferably, 0.0 to 15% by weight, most preferably, 0.01 to 12% by weight, including all ranges contained herein.

[0065] The oral care composition of the present invention can be used in methods that benefit individual teeth, including the step of applying the composition to at least one surface of an individual tooth. In particular, the oral care composition of the present invention can be used in methods for whitening teeth and / or improving personal oral hygiene, including the step of applying the composition to at least one surface of an individual tooth. Preferably, the method is non-therapeutic. The oral care composition of the present invention can also be used, or alternatively, for whitening teeth, and / or for improving personal oral hygiene, and / or for preparing medicaments for whitening teeth and / or improving personal oral hygiene. Preferably, this use is non-therapeutic.

[0066] Typically, the composition can be packaged. In toothpaste or gel form, the composition can be packaged in conventional plastic laminates, metal tubes, or single-compartment dispensers. The composition can be applied to the tooth surface by any physical means, such as a toothbrush, fingertips, or by an applicator applied directly to sensitive areas. In liquid mouthwash form, the composition can be packaged in bottles, sachets, or other convenient containers.

[0067] The oral care composition of the present invention is preferably toothpaste or gel. When the oral care composition is toothpaste or gel, its viscosity is typically from about 30,000 to 180,000 centipoise, preferably from 60,000 to 170,000 centipoise, and most preferably from 65,000 to 165,000 centipoise, obtained by measuring at room temperature (25°C) for 1 minute using a Brookfield viscometer with a 93 / 94 shaft at 5 rpm.

[0068] This composition is effective even when used in an individual's daily oral hygiene routine. For example, the composition can be brushed onto teeth and / or rinsed around the inside of an individual's mouth. The composition can be in contact with teeth for a period of time, for example, from 1 second to 20 hours. More preferably, from 1 second to 10 hours, even more preferably from 10 seconds to 1 hour, and most preferably from 30 seconds to 5 minutes. The composition can be used daily, for example, once, twice, or three times a day.

[0069] The following embodiments are provided to illustrate the invention. These embodiments are not intended to limit the scope of the claims. Detailed Implementation

[0070] Example

[0071] Example 1

[0072] This example demonstrates pigment deposition. All components are expressed as a weight percentage of the total formulation and as levels of active ingredients.

[0073] Table 1

[0074]

[0075] a. Clariant’s trade name Cosmenyl Blue A4R CI74160 (pigment blue 15:1) dispersion in water / glycerin.

[0076] b. Clariant's product name Clear's commercially available octanoyl / hexanoyl methyl glucamide.

[0077] c.Clariant's product name Flex's commercially available lauroyl / myristoyl methyl glucamide.

[0078] d.Clariant's product name is Sense's commercially available sunflower acylmethyl glucamide.

[0079] method

[0080] To evaluate pigment deposition, the following in vitro tests were performed. Color difference, expressed as CIELAB delta E (ΔE) values, was calculated based on L*, a*, and b* values ​​measured using DigiEye (VeriVide, England), using the following formula:

[0081]

[0082] Hydroxyapatite (HAP) discs were used as substrates. Baselines L*, a*, and b* of the HAP discs were measured using a DigiEye (VeriVide, England). Four HAP discs were used for each sample. The HAP discs were immersed in deionized (DI) water for 1 hour, and then immersed in different samples for 24 hours. The HAP discs were then rinsed with 40 mL of DI water and gently shaken by hand 6 times. Residual moisture on the HAP discs was absorbed by paper towels. After this step, the L*, a*, and b* values ​​of each HAP disc were remeasured, and the difference in E (ΔE) from the baseline was calculated based on the measured values ​​and statistical analysis was performed.

[0083] result

[0084] The results are summarized in Table 2. The higher the average ΔE value, the more pigment is deposited.

[0085] Table 2

[0086]

[0087] The results show that, compared with other samples, sample 4 exhibits a significantly higher ΔE value (p<0.05), indicating that its pigment deposition is much better.

Claims

1. An oral care composition comprising: (a) 0.01 to 10% by weight of the deposited polymer; (b) Polyhydroxy fatty acid amide surfactants of formula (I): (I) Where R 1 It is a C1-C4 alkyl or hydroxylated C1-C4 alkyl; R 2 It is a straight-chain or branched, saturated or unsaturated hydrocarbon chain with 15 to 21 carbon atoms; and (c) Beneficial agents selected from optical agents, antimicrobial agents, and mixtures thereof; The deposited polymers mentioned above include xanthan gum, sodium alginate, pectin, modified starch, gelatin, carrageenan, gellan gum, fenugreek gum, konjac gum, tragacanth gum, arabic gum, γ-polyglutamic acid, sodium heparin, copolymers of methyl vinyl ether and maleic anhydride, polyacrylic acid, polystyrene sulfonate, deoxyribonucleic acid, poly(allylamine), locust bean gum, guar gum, polyglycolic acid, polylactic acid, poly(glycolic acid-co-lactic acid), chitosan, humic acid, phytic acid, derivatives thereof, or mixtures thereof.

2. The oral care composition according to claim 1, wherein the deposited polymer comprises xanthan gum, sodium alginate, pectin, modified starch, gelatin, carrageenan, gellan gum, fenugreek gum, konjac gum, tragacanth gum, guilarin gum, γ-polyglutamic acid, phytic acid, derivatives thereof, or mixtures thereof.

3. The oral care composition according to claim 1 or 2, wherein the deposited polymer comprises xanthan gum and / or its derivatives.

4. The oral care composition according to claim 1 or 2, wherein the composition contains 0.02 to 5% by weight of the deposited polymer.

5. The oral care composition of claim 4, wherein the composition contains 0.05 to 3% by weight of the deposited polymer.

6. The oral care composition according to claim 1 or 2, wherein R 2 It is an alkyl, alkenyl, aryl or aralkyl group having 15 to 21 carbon atoms.

7. The oral care composition according to claim 6, wherein R 2 It is an alkyl, alkenyl, aryl, or aralkyl group having 15 to 19 carbon atoms.

8. The oral care composition according to claim 1 or 2, wherein R 1 It is a C1-C2 alkyl group.

9. The oral care composition according to claim 8, wherein R 1 It is a methyl group.

10. The oral care composition according to claim 1 or 2, wherein R 1 For methyl, R 2 It is an alkyl group having 15 to 21 carbon atoms.

11. The oral care composition of claim 10, wherein R 1 For methyl, R 2 It is an alkyl group having 15 to 19 carbon atoms.

12. The oral care composition according to claim 1 or 2, wherein the polyhydroxy fatty acid amide surfactant comprises at least 60% by weight of the following polyhydroxy fatty acid amide, wherein R 1 For methyl, R 2 C 17 alkyl.

13. The oral care composition of claim 12, wherein the polyhydroxy fatty acid amide surfactant comprises 70 to 100% of the following polyhydroxy fatty acid amide, wherein R 1 For methyl, R 2 C 17 alkyl.

14. The oral care composition of claim 13, wherein the polyhydroxy fatty acid amide surfactant comprises 80 to 100% of the following polyhydroxy fatty acid amide, wherein R 1 For methyl, R 2 C 17 alkyl.

15. The oral care composition according to claim 1 or 2, wherein the polyhydroxy fatty acid amide surfactant is a polyhydroxy fatty acid amide of the following type, wherein R 1 For methyl, R 2 C 17 alkyl.

16. The oral care composition according to claim 1 or 2, wherein the composition contains 0.01 to 10% by weight of the polyhydroxy fatty acid amide surfactant.

17. The oral care composition of claim 16, wherein the composition contains 0.1 to 8% by weight of the polyhydroxy fatty acid amide surfactant.

18. The oral care composition according to claim 1 or 2, wherein the beneficial agent is an optical agent selected from pigments, dyes, mica, TiO2-coated mica, titanium dioxide, calcium silicate-coated titanium dioxide, and mixtures thereof.

19. The oral care composition of claim 18, wherein the beneficial agent is a pigment with a hue angle h of 220 to 320 degrees in the CIELAB system.

20. The oral care composition of claim 19, wherein the beneficial agent is a pigment with a hue angle h of 250 to 290 degrees in the CIELAB system.

21. The oral care composition of claim 19, wherein the pigment is a blue pigment.

22. The oral care composition of claim 21, wherein the blue pigment is phthalocyanine blue pigment.

23. The oral care composition of claim 22, wherein the phthalocyanine blue pigment is selected from α-copper phthalocyanine pigment blue 15, pigment blue 15:1, pigment blue 15:2, and mixtures thereof.

24. The oral care composition of claim 23, wherein the phthalocyanine blue pigment is Pigment Blue 15:

1.

25. The oral care composition according to claim 1 or 2, wherein the beneficial agent is an antimicrobial agent.

26. The oral care composition of claim 25, wherein the antimicrobial agent is selected from zinc compounds including zinc oxide, zinc chloride, zinc acetate, zinc ascorbate, zinc sulfate, zinc nitrate, zinc citrate, zinc lactate, zinc peroxide, zinc fluoride, zinc ammonium sulfate, zinc bromide, zinc iodide, zinc gluconate, zinc tartrate, zinc succinate, zinc formate, zinc phenolsulfonate, zinc salicylate, zinc glycerophosphate, and mixtures thereof.

27. The oral care composition of claim 26, wherein the antimicrobial agent is zinc citrate.

28. Use of the oral care composition according to any one of claims 1 to 27 in the manufacture of a medicament for whitening teeth and / or improving personal oral hygiene.

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