High integration R wave triggered tumor therapeutic apparatus

Abstract

The application discloses a high-integration R-wave triggered tumor therapeutic instrument, and relates to the technical field of medical instruments for tumor ablation, which comprises a human body R-wave detection module, a signal generator, a primary matching circuit and a high-frequency transformer.The human body R-wave detection module is used for detecting a human body R-wave signal; the signal generator is used for obtaining a narrow pulse signal with nanometer width according to the human body R-wave signal; and the primary matching circuit is used for matching the narrow pulse signal with nanometer width to an input side of the high-frequency transformer, so that the high-frequency transformer outputs a high-voltage signal required for treating the human body.The application adopts the high-frequency transformer to realize signal amplification, and then can adopt the signal generator capable of outputting the narrow pulse signal with nanometer width and the high-frequency transformer with small volume under the condition that the instantaneous voltage of the output reaches tens of kilovolts, and does not need to depend on an external electrocardiosynchronizer any more, so that the volume of the therapeutic instrument is reduced; the pulse width can be truly several nanometers, and the damage to the benign tissues around the diseased cells is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical instruments for tumor ablation, in particular to a high-integration R-wave triggered tumor treatment instrument. BACKGROUND

[0002] Nanoknife is a brand-new tumor ablation technology, which forms nanoscale permanent perforation on tumor cells by releasing high-voltage pulses, destroys the cell balance, and makes the cells rapidly apoptotic. Therefore, nanoknife is also called irreversible electroporation in medical science. Compared with traditional tumor thermal ablation methods such as microwave and radio frequency, nanoknife tumor ablation has the advantages of preserving normal vascular structures in the ablation area, higher safety, activating the body's immune system, and being beneficial to the recovery of organ function.

[0003] Nanoknife mainly applies narrow pulse and high-voltage direct current technology. The minimum pulse width determines the minimum sustainable working time of nanoknife, and is the main feature that distinguishes nanoknife from microwave and radio frequency ablation. Because nanoknife uses narrower pulses, nanoknife can achieve lesion cell perforation through electric field, rather than traditional thermal ablation. It can be said that the narrower the pulse width, the better the electric field perforation effect. Because the duration of narrow pulse is short, the voltage must be increased to ensure the energy of single pulse. Generally, nanoknife requires a voltage of 10KV to 30KV.

[0004] The scheme adopted by the existing products on the market is to use high-voltage capacitor charging when the power supply is not working and instantaneous discharge when the power supply is working. This puts high requirements on the power supply design of nanoknife. At the same time, due to the characteristics of high-voltage capacitor charging and discharging, if a very narrow high-voltage pulse output is to be achieved, the volume of the high-voltage capacitor must be very large, and the volume of the entire product must be very large. Therefore, limited by the high-voltage capacitor, the narrowest pulse width of the existing ablation instrument on the market can only be a few microseconds, which is difficult to achieve nanoscale, and the instantaneous voltage is difficult to reach tens of kilovolts, resulting in insufficient treatment effect.

[0005] At the same time, when stimulating cancer cells of a patient, nanoknife will also cause the patient's blood pressure and heart rate to rise. The stimulation of nanoknife needs to be aligned with the heart rate. The existing ablation instruments on the market do not have R-wave detection function, and need an external electrocardiosynchronizer to output an electrocardio R-wave signal to nanoknife for signal synchronization, which is not conducive to the miniaturization of the product. SUMMARY

[0006] The present application provides a high-integration R-wave triggered tumor treatment instrument, which can alleviate the above problems.

[0007] In order to alleviate the above problems, the technical scheme adopted by the present application is as follows:

[0008] A high-integration R-wave triggered tumor therapeutic instrument comprises:

[0009] A human body R-wave detection module is configured to detect a human body R-wave signal.

[0010] A signal generator is configured to obtain a narrow pulse signal with a nanometer width according to the human body R-wave signal.

[0011] A primary matching circuit and a high-frequency transformer are configured to match the narrow pulse signal with the nanometer width to an input side of the high-frequency transformer, so that the high-frequency transformer outputs a high-voltage signal required for treating the human body.

[0012] In a preferred embodiment of the present application, the high-integration R-wave triggered tumor therapeutic instrument further comprises a power detection protection module configured to detect a signal power of an output side of the high-frequency transformer and feed back to the signal generator to correct the narrow pulse signal with the nanometer width output by the signal generator, so as to ensure that the output power of the high-frequency transformer is constant.

[0013] In a preferred embodiment of the present application, the high-integration R-wave triggered tumor therapeutic instrument further comprises a human-computer interaction platform comprising a four-core Cortex-A53 processor, a touch 7-inch display screen of an android 10 operating system, and is configured to configure signal pulse and voltage parameters and display a human body treatment state.

[0014] In a preferred embodiment of the present application, when the signal power of the output side of the high-frequency transformer is greater than a protection value, the signal generator stops signal output.

[0015] In a preferred embodiment of the present application, the signal generator comprises, from an input side to an output side, an FPGA chip, a DA conversion chip, a primary operational amplifier and a secondary operational amplifier connected in series.

[0016] In a preferred embodiment of the present application, the FPGA chip is configured to generate a 14-bit digital narrow pulse signal according to the human body R-wave signal; the DA conversion chip is configured to convert the 14-bit digital narrow pulse signal into an analog narrow pulse signal with a voltage of 3.3V; the primary operational amplifier is configured to complete single-end to differential conversion based on the analog narrow pulse signal with the voltage of 3.3V, so as to obtain an analog narrow pulse signal with a voltage of ±3.3V; and the secondary operational amplifier is configured to perform differential voltage amplification on the analog narrow pulse signal with the voltage of ±3.3V, so as to obtain an analog narrow pulse signal with a voltage of ±12V as the narrow pulse signal with the nanometer width finally output by the signal generator.

[0017] In a preferred embodiment of the present application, the method for generating the 14-bit digital narrow pulse signal comprises the following steps:

[0018] S1, the FPGA chip acquires signal generation control instructions;

[0019] S2, judging whether the signal power of the output side of the high-frequency transformer is greater than a protection value, if yes, the FPGA chip stops generating 14bit digital narrow pulse signals, if not, executing step S3;

[0020] S3, judging whether the signal power of the output side of the high-frequency transformer is higher than a required power, if yes, generating a power adjustment parameter for reducing the driving of the DA conversion chip, then executing step S4, if not, generating a power adjustment parameter for increasing the driving of the DA conversion chip, then executing step S4;

[0021] S4, generating an initial pulse signal according to the signal generation control instructions, then obtaining 14bit digital narrow pulse signals through signal delay output according to the initial pulse signal, the power adjustment parameter and the human body R wave signal.

[0022] Compared with the prior art, the beneficial effects of the present application are:

[0023] 1) without using the traditional capacitor discharge method to generate high-voltage narrow pulses, but using a high-frequency transformer to realize signal amplification, and then in the case of ensuring that the output transient voltage reaches tens of kilovolts, a signal generator capable of outputting nanometer-level width pulse signals and a small-size high-frequency transformer can be used to reduce the size of the therapeutic instrument;

[0024] 2) the pulse width can be truly made to be several nanometers, and narrower treatment pulses reduce the energy of single pulses, thereby reducing the damage to the surrounding benign tissues of the diseased cells;

[0025] 3) the ECG R wave detection module is integrated, without relying on an external ECG synchronizer, further reducing the size of the device;

[0026] 4) using the DA of the signal generator, the pulse width and signal amplitude are adjustable, and the real-time power detection at the back end, the power closed-loop regulation is realized from the signal source.

[0027] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the following embodiments of the present application are described in detail below, and the accompanying drawings are described as follows. BRIEF DESCRIPTION OF DRAWINGS

[0028] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiments. It should be understood that the following drawings only show some of the embodiments of the present application, and therefore should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can also be obtained without creative labor.

[0029] Figure 1 is the system block diagram of the high-integration R-wave triggered tumor therapeutic instrument according to the present application;

[0030] Figure 2 is the generation process of the FPGA digital narrow pulse signal according to the present application;

[0031] Figure 3 is the processing process of the narrow pulse signal by the signal generator analog circuit according to the present application;

[0032] Figure 4 is the extraction process of the human body R-wave signal according to the present application. DETAILED DESCRIPTION

[0033] In order to make the purpose, technical solutions and advantages of the embodiments of the present application more clear, the following will combine the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are some of the embodiments of the present application, but not all the embodiments.

[0034] Please refer to Figure 1 The high-integration R-wave triggered tumor therapeutic instrument according to the present application comprises a human body R-wave detection module, a power detection protection module, a man-machine interaction platform, and a signal generator, a primary matching circuit, a high-frequency transformer and a power system connected in sequence.

[0035] 1. The man-machine interaction platform is used for basic parameter configuration, treatment state display, etc. of the present application, including signal pulse, voltage setting, etc. A touch 7-inch display screen based on a four-core Cortex-A53 processor and an android 10 operating system is adopted.

[0036] The man-machine interaction platform according to the present application has the following functions:

[0037] 1) Basic parameter configuration, treatment switch input, R-wave, treatment pulse timing display and other man-machine interaction contents;

[0038] 2) Relying on its own calculation unit, the treatment parameters can be automatically calculated and generated for the doctor to refer to according to the input tumor type and volume, size and other parameters during treatment, and the treatment parameters of the existing cases can also be provided for reference by using the similar cases stored in the background server memory;

[0039] 3) On the hardware is equipped with 5G network, Bluetooth and wired network, meet the hardware requirements of the application for telemedicine, facilitate the realization of manufacturer's remote monitoring of equipment, meet the user and the remote communication of manufacturer, manufacturer is convenient for direct remote realization of guiding and assisting to user.

[0040] 2、Signal generator is the signal source of the pulse signal required for treatment, which can accept the instruction signal sent by the human-computer interaction platform, output the narrow pulse signal of nanometer width required for treatment according to the human R wave signal.

[0041] The signal generator plays a crucial role in the application, which needs to complete the corresponding signal parameter configuration, narrow pulse signal generation and output pulse power control according to the configuration instruction of the human-computer interaction platform.

[0042] In the application, the signal generator adopts the architecture of FPGA+DA+operational amplifier, and includes FPGA chip, DA conversion chip, first operational amplifier and second operational amplifier connected in series from the input side to the output side, and the FPGA chip is electrically connected with the human R wave detection module and the power detection protection module.

[0043] The FPGA chip is the control center of the signal generator, mainly responsible for communication with the human-computer interaction platform, including acceptance of instructions and uploading of state instructions, reception of human R wave signals, reception of power detection signals (signal power on the output side of the high-frequency transformer), and generation of DA drive signals. The FPGA chip selected in the application is XC6SLX25 of xilinx, and the basic execution process is as shown in Figure 2 .

[0044] The digital signal output by the FPGA chip will be converted from digital signal to analog signal through the DA conversion chip, and the DA conversion chip adopted in the application is 14bit wide, which can realize 42dB dynamic range output, and the maximum output voltage is 3.3V. At this time, the signal still needs to be amplified through two-stage operational amplifier, so as to output the ±12V narrow pulse signal matched with the voltage and current of the next stage, that is, the narrow pulse signal of nanometer width required for quality human body, as shown in Figure 3 .

[0045] 3, The first matching circuit is used for matching the output signal of the signal generator and the input signal of the high-frequency transformer, mainly for current amplification. That is, the ±12V narrow pulse signal output by the signal generator is further amplified in current, and the signal obtained through the first matching circuit is a narrow pulse signal with large current and low voltage. At this time, the signal energy is already high enough, and the signal can be amplified to the voltage value required for treatment through the last-stage high-frequency transformer.

[0046] 4. The human body R-wave detection module is designed to align the treatment narrow pulse signal with the heart rate, such as... Figure 4 As shown, this invention employs six external detection inputs, with an external interface similar to that of a general electrocardiograph. The back-end processing utilizes an FPGA as the main controller, ensuring a constant delay between the actual signal and the sampled signal. Measured delays are a few microseconds, fully meeting the delay requirements for treatment. Since the human R-wave signal is weak, typically only a few mV, this module uses a 24-bit resolution high-sensitivity AD conversion chip to ensure detection of this weak signal. Furthermore, to reduce interference from high-frequency transformer energy radiation on the human R-wave detection module, a metal shielding shell is used on the outside of the module circuitry, and an isolated power supply is also used for the input power.

[0047] 5. The power detection and protection module detects the signal power at the output side of the high-frequency transformer and feeds it back to the signal generator to correct the narrow pulse signal with a nanometer-wide width output by the signal generator, ensuring that the output power of the high-frequency transformer remains constant. See [link to relevant documentation]. Figure 2 As shown. When the detected power exceeds the protection value, a protection mechanism is triggered, shutting down the signal generator's output.

[0048] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A high-integration R-wave triggered tumor therapeutic apparatus, characterized in that, The utility model relates to a high integration R wave triggered tumor therapeutic instrument, including: a human body R wave detection module for detecting a human body R wave signal; a signal generator for obtaining a narrow pulse signal of nanometer width according to the human body R wave signal; a primary matching circuit and a high-frequency transformer, the primary matching circuit is used for matching the narrow pulse signal of nanometer width to the input side of the high-frequency transformer, so that the high-frequency transformer outputs a high-voltage signal required for treating the human body; The high integration R wave triggered tumor therapeutic instrument further comprises a power detection protection module for detecting the signal power of the output side of the high-frequency transformer and feeding back to the signal generator to correct the narrow pulse signal of nanometer width output by the signal generator, so as to ensure that the output power of the high-frequency transformer is constant. The signal generator comprises, from the input side to the output side, an FPGA chip, a DA conversion chip, a primary operational amplifier and a secondary operational amplifier connected in series, and the FPGA chip is electrically connected to the human body R wave detection module and the power detection protection module.

2. The high-integration R-wave triggered tumor therapeutic apparatus according to claim 1, wherein, The high integration R wave triggered tumor therapeutic instrument further comprises a man-machine interaction platform comprising a four-core Cortex-A53 processor, a touch 7-inch display screen of an android 10 operating system, which is used for configuring signal pulse and voltage parameters and displaying the treatment state of the human body.

3. The high-integration R-wave triggered tumor therapeutic apparatus according to claim 1, wherein, When the signal power of the output side of the high-frequency transformer is greater than the protection value, the signal generator stops signal output.

4. The high-integration R-wave triggered tumor therapeutic apparatus according to claim 1, wherein, The FPGA chip is used for generating a 14-bit digital narrow pulse signal according to the human body R wave signal; the DA conversion chip is used for converting the 14-bit digital narrow pulse signal into an analog narrow pulse signal of 3.3 V; the primary operational amplifier is used for completing single-ended to differential conversion based on the analog narrow pulse signal of 3.3 V to obtain an analog narrow pulse signal of ±3.3 V; and the secondary operational amplifier is used for performing differential voltage amplification on the analog narrow pulse signal of ±3.3 V to obtain an analog narrow pulse signal of ±12 V as the narrow pulse signal of nanometer width finally output by the signal generator.

5. The high-integration R-wave triggered tumor therapeutic apparatus according to claim 4, wherein, The method for generating the 14-bit digital narrow pulse signal comprises the following steps: S1, the FPGA chip acquires a signal generation control instruction; S2, it is judged whether the signal power of the output side of the high-frequency transformer is greater than the protection value, if yes, the FPGA chip stops generating the 14-bit digital narrow pulse signal, if not, step S3 is executed; S3, it is judged whether the signal power of the output side of the high-frequency transformer is higher than the required power, if yes, a power adjustment parameter for reducing the driving of the DA conversion chip is generated, and then step S4 is executed, if not, a power adjustment parameter for increasing the driving of the DA conversion chip is generated, and then step S4 is executed; S4, an initial pulse signal is generated according to the signal generation control instruction, and then a 14-bit digital narrow pulse signal is obtained through signal delay output according to the initial pulse signal, the power adjustment parameter and the human body R wave signal.

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