Wearable device for skin testing

Abstract

The application provides a wearable device for skin test, which comprises a main body, a carrier liquid device and an imaging device. The main body comprises a first assembly part and a second assembly part. The carrier liquid device is assembled on the main body through the first assembly part and has a reaction area for contacting the skin of a wearer. The imaging device is assembled on the main body through the second assembly part and is configured to image the skin. The wearable device for skin test provided by the application provides a small, convenient and home-use skin test solution.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical detection, in particular to a wearable device for skin test. BACKGROUND

[0002] With the continuous development of biological detection technology, it is found that some diseases related to brain health level, such as some mental and neurological disorders, can be detected by a method of skin test. This is based on the homology of cells of various tissues and organs of the human body, and the cell structures of different tissues and organs are similar. Therefore, the structural integrity of central nervous cells can be reflected by performing a skin test on the peripheral skin.

[0003] For example, the biological membrane structure is the first line of defense to maintain cell integrity and resist external invasion, and is also a signal relay station for cell communication with the outside world and a material basis for information transmission between brain nerve cells. For a healthy testee, when a niacin reagent contacts the skin surface, the change of the molecules constituting the cell membrane structure will cause a transient redness and swelling reaction of the local skin. However, when the cell membrane structure of the testee has defects, the skin reaction of the testee will be blocked, and the redness and swelling reaction will be impaired; accordingly, the testee's nerve cells may have similar cell membrane structure defects, and therefore the testee may have a disease related to brain health. Therefore, a skin test can be performed using a niacin reagent (or a niacin derivative reagent) to detect the brain health level of the testee.

[0004] The test conditions required by the existing skin test are very harsh. On the one hand, in order to ensure that the light and time when the testee's skin is photographed meet the requirements, the volume of the test equipment is large, and a closed cabinet that can accommodate the testee's skin is needed. Therefore, the testee can only go to a special test institution to perform the test, which makes the test very inconvenient. In addition, some patients may give up going to the test institution for the test due to the stigma, delaying diagnosis. On the other hand, the operation of the existing test equipment is extremely complex, and a trained professional operator is needed to operate it to ensure that the contact time of the testee's skin with the test reagent, the photographing time of the testee's skin, and the light of the photographing meet the requirements. SUMMARY

[0005] To solve or at least alleviate one or more of the problems such as the above or other existing problems, the present application provides the following technical solutions.

[0006] According to an aspect of the present application, a wearable device for skin test is provided. The wearable device comprises: a main body comprising a first fitting part and a second fitting part; a carrier liquid device fitted to the main body via the first fitting part and having a reaction area to contact a test skin of a wearer; and an imaging device fitted to the main body via the second fitting part and configured to image the test skin.

[0007] As an alternative or supplement to the above-mentioned scheme, according to an embodiment of the present application, the wearable device further comprises a test paper assembly. The test paper assembly further comprises a mounting sheath and a test paper, the mounting sheath is sleeved on the reaction area of the carrier liquid device, and the test paper is connected to the mounting sheath and can carry a test reagent.

[0008] As an alternative or supplement to the above-mentioned scheme, according to an embodiment of the present application, the wearable device further comprises a test paper assembly. The test paper assembly further comprises a mounting sheath and a test paper, the mounting sheath is sleeved on the reaction area of the carrier liquid device, and the test paper is connected to the mounting sheath and can carry a test reagent.

[0009] As an alternative or supplement to the above-mentioned scheme, according to an embodiment of the present application, the wearable device further comprises a test paper assembly. The test paper assembly further comprises a mounting sheath and a test paper, the mounting sheath is sleeved on the reaction area of the carrier liquid device, and the test paper is connected to the mounting sheath and can carry a test reagent.

[0010] As an alternative or supplement to the above-mentioned scheme, according to an embodiment of the present application, the wearable device further comprises a test paper assembly. The test paper assembly further comprises a mounting sheath and a test paper, the mounting sheath is sleeved on the reaction area of the carrier liquid device, and the test paper is connected to the mounting sheath and can carry a test reagent.

[0011] As an alternative or supplement to the above-mentioned scheme, according to an embodiment of the present application, the wearable device further comprises a test paper assembly. The test paper assembly further comprises a mounting sheath and a test paper, the mounting sheath is sleeved on the reaction area of the carrier liquid device, and the test paper is connected to the mounting sheath and can carry a test reagent.

[0012] As an alternative or supplement to the above-mentioned scheme, according to an embodiment of the present application, the wearable device further comprises a test paper assembly. The test paper assembly further comprises a mounting sheath and a test paper, the mounting sheath is sleeved on the reaction area of the carrier liquid device, and the test paper is connected to the mounting sheath and can carry a test reagent.

[0013] As an alternative or supplement to the above-mentioned scheme, according to an embodiment of the present application, the wearable device further comprises a test paper assembly. The test paper assembly further comprises a mounting sheath and a test paper, the mounting sheath is sleeved on the reaction area of the carrier liquid device, and the test paper is connected to the mounting sheath and can carry a test reagent.

[0014] As an alternative or supplement to the above-mentioned solutions, in the wearable device according to an embodiment of the present application, the extraction unit is further configured to construct a color model based on the imaging result, and extract the feature information associated with the brain health level of the wearer based on image pixel color information in the color model.

[0015] As an alternative or supplement to the above-mentioned solutions, in the wearable device according to an embodiment of the present application, further comprising: an output device configured to display the brain health level of the wearer determined by the processing device; and / or a communication device configured to send data outside the wearable device for processing or storing the data. Wherein, the data includes the imaging result and / or the determined brain health level of the wearer.

[0016] As an alternative or supplement to the above-mentioned solutions, in the wearable device according to an embodiment of the present application, the brain health level of the wearer is the health level of the wearer with respect to mental diseases and / or neurological diseases.

[0017] As an alternative or supplement to the above-mentioned solutions, in the wearable device according to an embodiment of the present application, the mental diseases at least include schizophrenia spectrum and other psychotic disorders, bipolar disorders, depressive disorders, anxiety disorders, trauma and stress-related disorders, and neurodevelopmental disorders; and / or the neurological diseases at least include stroke, posterior circulation ischemia, Parkinson's disease, Parkinson's syndrome, dementia, and mild cognitive impairment.

[0018] As an alternative or supplement to the above-mentioned solutions, in the wearable device according to an embodiment of the present application, further comprising: a timing device configured to start timing from the time when the test reagent comes into contact with the measured skin.

[0019] As an alternative or supplement to the above-mentioned solutions, in the wearable device according to an embodiment of the present application, further comprising: the timing device is further configured to issue a first instruction in response to the timing reaching a predetermined first time threshold. Wherein, the first instruction indicates to issue a reminder signal and / or instruct to unload the carrier liquid device from the subject.

[0020] As an alternative or supplement to the above-mentioned solutions, in the wearable device according to an embodiment of the present application, the timing device is further configured to issue a second instruction in response to the timing reaching a predetermined one or more second time thresholds. Wherein, the second instruction instructs the imaging device to image the measured skin.

[0021] As an alternative or supplement to the above-mentioned solutions, in the wearable device according to an embodiment of the present application, the test reagent is an HCAR2 receptor activator or an HCAR3 receptor activator or an ester thereof.

[0022] As an alternative or supplement to the above scheme, in the wearable device according to an embodiment of the present application, the test reagent is a nicotinic acid or a derivative reagent thereof.

[0023] As an alternative or supplement to the above scheme, in the wearable device according to an embodiment of the present application, the test reagent is a nicotinic acid reagent, a nicotinic acid methyl ester reagent, a nicotinic acid ethyl ester reagent, or a combination thereof.

[0024] The wearable device for skin test according to the present application realizes a small, convenient, and home-use skin test scheme. The wearer can perform skin test anytime and anywhere without the need to specially go to a test institution or find a professional operator to perform the test. BRIEF DESCRIPTION OF DRAWINGS

[0025] The above and other objects and advantages of the present application will become more apparent by describing in detail the following embodiments thereof in connection with the accompanying drawings.

[0026] Figure 1 A first perspective exploded view of a wearable device 100 for skin test according to an embodiment of the present application is shown.

[0027] Figure 2 A second perspective exploded view of the wearable device 100 for skin test according to an embodiment of the present application is shown.

[0028] Figure 3 An exploded view of a test paper assembly 140 of the wearable device 100 for skin test according to an embodiment of the present application is shown.

[0029] Figure 4 A structural block diagram of a wearable device 400 for skin test to which an embodiment of the present application can be applied is shown. DETAILED DESCRIPTION

[0030] It should be understood that the terms "first", "second", and the like, used in the description and the claims of the present application are used to distinguish between similar objects, not necessarily in an ordinal sense or in a particular sequence. Also, the terms "comprise", "include", "have", and the like, are meant to be interpreted inclusively rather than exclusively, unless otherwise specifically indicated.

[0031] Hereinafter, the exemplary embodiments according to the present application will be described in detail with reference to the accompanying drawings. Figure 1 and Figure 2 A front and back exploded view of a wearable device 100 for skin test according to an embodiment of the present application is shown. The wearable device 100 includes a main body 110, a carrier liquid device 120, and an imaging device 130.

[0032] As Figure 1 and Figure 2As shown, the main body 110 can include a fitting portion 111 in the form of a cavity. The carrier liquid device 120 can be detachably fitted to the main body 110 via the fitting portion 111, and the imaging device 130 can also be detachably fitted to the main body 110 via the fitting portion 111.

[0033] In the embodiment shown, when the imaging device 130 is fitted to the main body 110 via the fitting portion 111, a closed space can be formed between the wearable device 110 and the skin under test. This can provide a space with stable lighting for imaging. As an example, the imaging device can be a CCD or COMS camera, a digital camera, etc., which can take an image of the skin under test after a skin test. Figure 1 and Figure 2 In the embodiment shown, when the imaging device 130 is fitted to the main body 110 via the fitting portion 111, a closed space can be formed between the wearable device 110 and the skin under test. This can provide a space with stable lighting for imaging. As an example, the imaging device can be a CCD or COMS camera, a digital camera, etc., which can take an image of the skin under test after a skin test.

[0034] It should be noted that, in the context of the present application, the fitting portion is not limited to being in the form of a cavity as exemplified in the embodiments of Figure 1 and Figure 2 In the embodiment shown, when the imaging device 130 is fitted to the main body 110 via the fitting portion 111, a closed space can be formed between the wearable device 110 and the skin under test. This can provide a space with stable lighting for imaging. As an example, the imaging device can be a CCD or COMS camera, a digital camera, etc., which can take an image of the skin under test after a skin test.

[0035] Further, the wearable device 100 can also include a test paper assembly 140. Figure 3 An exploded view of the test paper assembly 140 of the wearable device 100 is shown. The test paper assembly 140 can further include a mounting sheath 141 and a test paper 142. The mounting sheath 141 is sleeved on the reaction area 121 of the carrier liquid device 120. The test paper 142 is connected to the mounting sheath 141 and can carry test reagents. When the test reagents are added to the test paper 142, the test paper assembly is mounted to the reaction area 121 of the carrier liquid device 120, the carrier liquid device 120 is fitted to the main body 110, and the wearable device 100 is worn, the test reagents come into contact with the skin under test, thereby performing a skin test.

[0036] In addition, the test paper assembly 140 also includes a limiting frame 143. The limiting frame 143 is connected to the test paper 142 and limits the contact area of the test paper 142 with the skin under test. When the test reagents are added to the test paper 142, the limiting frame 143 can limit the contact area of the test reagents with the skin under test to the hollow reaction area of the limiting frame 143, so as to facilitate the positioning operation when the imaging result of the skin under test is extracted subsequently. In addition, when an excessive amount of test reagents is dripped on the test paper 142, the limiting frame 143 can also guide the excessive amount of test reagents to the outside of the hollow reaction area, so as to avoid the excessive amount of test reagents affecting the result of the skin test.

[0037] Optionally, the test paper assembly 140 can be replaceable or disposable, thereby ensuring accuracy and hygiene of each skin test.

[0038] It is noted that, in the embodiments shown in Figure 1 and Figure 2 , the carrier fluid device 120 and the imaging device 130 can be assembled to the main body 110 using the same assembly portion 111, but the present application is not limited thereto. In other embodiments of the present application, the carrier fluid device and the imaging device can be assembled to the main body using different assembly portions, respectively, as long as they can perform skin test and imaging on the same region of the skin of the subject, respectively.

[0039] It is further noted that, in the embodiments shown in Figure 1 and Figure 2 , the carrier fluid device 120 and the imaging device 130 can be detachably assembled to the main body 110 of the wearable device 100, but the present application is not limited thereto. In other embodiments of the present application, the carrier fluid device and the imaging device can be fixedly assembled to the main body, rather than detachably.

[0040] In the context of the present application, the "test reagent" is intended to mean a reagent that can be in contact with the skin to perform a skin test. For example, the test reagent can be a reagent that can determine the brain health level of the wearer. In the context of the present application, the "brain health level of the wearer" is intended to mean a health level with respect to a disease that can be affected by the state of cells in the brain, for example, a health level with respect to a mental disease, a neurological disease, etc. The mental disease can include a schizophrenia spectrum and other psychotic disorders, bipolar disorders, depressive disorders, anxiety disorders, trauma and stress-related disorders, and neurodevelopmental disorders (including intellectual developmental disorders, autism spectrum disorder, attention-deficit / hyperactivity disorder, childhood communication disorder, specific learning disorders, tic disorders, movement disorders, and other types of neurodevelopmental disorders), etc. The neurological disease can include stroke, posterior circulation ischemia, Parkinson's disease, Parkinson's syndrome, dementia (including Alzheimer's disease, Lewy body dementia, Parkinson's disease dementia, frontotemporal lobar degeneration, vascular dementia, and other types of dementia), mild cognitive impairment, etc. As an example, the test reagent can be an HCAR2 receptor activator or an HCAR3 receptor activator or an ester thereof, which can perform a skin test by activation of the HCAR2 receptor or the HCAR3 receptor. Further, the HCAR2 receptor activator or the HCAR3 receptor activator or the ester thereof can be a niacin or a derivative reagent thereof, such as a niacin reagent, a niacin methyl ester reagent, a niacin ethyl ester reagent, or a combination thereof.

[0041] In Figure 1 and Figure 2In the illustrated embodiment, the wearable device 100 is in the form of a wristband. It will be readily appreciated by those skilled in the art that the form of the wearable device is not limited in the context of the present application and can also include any wearable device that is capable of enabling the test reagent on the carrier liquid device to contact the skin under test to perform the skin test and enabling the imaging device to image the skin under test, which is fixed at a position on the wearer's arm, leg, torso, etc.

[0042] Figure 4 A structural block diagram of a wearable device 400 according to an embodiment of the present application is shown. The wearable device 400 includes a main body 410, a carrier liquid device 420, an imaging device 430 and a processing device 450. The main body 410 includes a first fitting portion and a second fitting portion. The carrier liquid device 420 is fitted to the main body 410 via the first fitting portion and has a reaction area that contacts the skin under test of the wearer. The imaging device 430 is fitted to the main body 410 via the second fitting portion and is configured to image the skin under test.

[0043] Optionally, the wearable device 400 can further include the processing device 450. The processing device 450 can be used to determine the brain health level of the wearer based on the imaging result of the imaging device 430. Further, the processing device 450 can include an extraction unit 451, a comparison unit 452 and a determination unit 453.

[0044] The extraction unit 451 is configured to extract feature information associated with the brain health level of the wearer based on the imaging result from the imaging device 430. The feature information can be, for example, a parameter such as color, area, perimeter or shape of a region of interest (e.g., a region that swells due to the skin test) in the imaging result.

[0045] In particular, the extraction unit 451 is further configured to construct a color model based on the imaging result and extract the feature information associated with the brain health level of the wearer based on image pixel color information in the color model. That is, a parameter such as color, area, perimeter or shape of a region of interest in the imaging result can be extracted based on the image pixel color information, for example. In one example, when the color model constructed is an HSI color model, the region of interest can be determined based on H component, I component, S component or a combination thereof in the HSI color model as the image pixel color information, so as to extract the parameter of the region of interest, i.e., extract the feature information associated with the brain health level of the wearer. In another example, when the color model constructed is a Lab color model, the region of interest can be determined based on L component, a component, b component or a combination thereof in the Lab color model as the image pixel color information, so as to extract the parameter of the region of interest, i.e., extract the feature information associated with the brain health level of the wearer.

[0046] The comparison unit 452 is configured to compare the feature information extracted by the extraction unit 451 with a predetermined threshold. Here, the predetermined threshold for the feature information is a threshold for a parameter such as color, area, perimeter, or shape of a region of interest in the imaging result (e.g., a region where redness occurs due to skin testing). The threshold can be artificially preset or trained by machine learning or the like.

[0047] The determination unit 453 is configured to determine the brain health level of the wearer according to the comparison result from the comparison unit. For example, when the area of the redness region extracted by the extraction unit 451 is less than the predetermined area threshold, the brain health level of the wearer is determined to be at risk of disease; when the area of the redness region extracted by the extraction unit 451 is greater than the predetermined area threshold, the brain health level of the wearer is determined to be healthy.

[0048] In one embodiment, the imaging result can be scored for redness degree in the extraction unit 451 as the feature information, and the scored score is compared with a score threshold in the comparison unit 452, and then the brain health level of the wearer is determined based on the comparison result in the determination unit 453, according to the method disclosed in the patent CN202110707754.0.

[0049] In a specific application, the processing device 450 can be implemented by any feasible chip, unit, module, etc. hardware, and of course, it is also allowed to be implemented by a combination of software and hardware.

[0050] The processing device 450 can also be configured to analyze and compare the test results of multiple detections of the wearer to determine the brain health level of the wearer at different times or under other conditions.

[0051] The wearable device 400 can also include an output device 460. The output device 460 is used to output the brain health level of the wearer determined by the processing device 450. As an example, the output device 460 can be a display 160 similar to that shown in FIG. 1, for presenting the brain health level of the wearer in a visual form. As another example, the output device can also be a speaker for presenting the brain health level of the wearer in the form of sound. Figure 1

[0052] The wearable device 400 can also include a communication device 470. The communication device 470 is used to send data outside the wearable device 400 for processing or storage, for example, sending the data to an external storage, processor, server, etc. in a wired or wireless form, such as a local, remote, cloud storage. Among them, the data sent includes the imaging result of the imaging device 430 and the brain health level of the wearer determined by the processing device 450.

[0053] ​The wearable device 400 can further comprise a timing device 380. The timing device 380 is configured to time from the start of the contact of the test reagent with the skin under test. The timing can be started, for example, in response to an input from the wearer or an operator of the wearable device 400 that the contact of the test reagent with the skin under test has started. The timing can also be started, for example, in response to an input that the liquid carrier device 420 is attached to the main body 410, i.e. the time of attachment of the liquid carrier device 420 to the main body 410 is approximated as the time of the start of the contact of the test reagent with the skin under test.

[0054] Further, the timing device 380 can be configured to issue a first instruction in response to the timing reaching a predetermined first time threshold. The first instruction can be indicative of issuing a reminder signal to remind the wearer or other operator of the wearable device 400 that the reaction time is over. Alternatively, the first instruction can be indicative of unloading (e.g. ejecting) the liquid carrier device 420 from the main body 410 (e.g. via the connection structure), thereby causing the test reagent to no longer be in contact with the skin and the skin test to be stopped.

[0055] The first time threshold can be a predetermined time during which the test reagent needs to be in contact with the skin during the skin test, e.g. 5 minutes, 10 minutes, 15 minutes, etc. any suitable time predetermined in accordance with the actual skin test requirements.

[0056] Further, the timing device 380 can be configured to issue a second instruction in response to the timing reaching one or more predetermined second time thresholds. The second instruction can be indicative of the imaging device 430 to image the skin under test. The second time threshold can be a predetermined time at which it is desired to take an image of the skin reaction caused by the skin test, e.g. 8 minutes, 12 minutes, 17 minutes, etc. any suitable time predetermined in accordance with the actual skin test requirements. It will be readily appreciated by the skilled person that the second time threshold is generally greater than the first time threshold, i.e. the imaging of the skin under test is performed after the test reagent has completed its contact with the skin. However, the scope of the present application does not exclude that the contact and imaging are performed at different times. For example, the timing can be started from the contact of the skin under test with the test reagent, the contact reaction is performed for 0 to 5 minutes, the imaging is performed at 7 minutes, followed by a further contact reaction for 8 to 10 minutes, and the imaging is performed at 12 minutes.

[0057] In an alternative embodiment, the artificial timing is started when the skin test is started (i.e. the contact of the skin under test with the test reagent is started), and the artificial instruction to unload the liquid carrier device from the wearable device 400 or to separate the skin under test from the test reagent is issued when the reaction time reaches the first time threshold. Similarly, the imaging device can be instructed to perform the imaging in response to an inputted instruction (e.g. an artificial instruction issued when the artificial timing reaches the second time threshold).

[0058] In summary, the wearable device according to one embodiment of the present application can provide a small, convenient, and home-use skin test solution. The wearer can complete the skin test by himself / herself anytime and anywhere, and monitor his / her own brain health level without the need to go to a test institution or find a professional operator to perform the test. This is conducive to the timely detection of related diseases, and provides the possibility for timely intervention of the disease. In addition, the wearable device according to one embodiment of the present application can analyze and obtain the test result of the wearer's brain health level in real time, and can also compare the test results of the wearer at different times and under different conditions.

[0059] It should be noted that some of the block diagrams in the drawings show only the functional blocks and not necessarily the physical or logical arrangement of the functional blocks. The functional blocks can be implemented in software, or in one or more hardware modules or integrated circuits, or in different network and / or processor devices and / or microcontroller devices.

[0060] It should also be understood that, in some alternative embodiments, the described functions / steps can not occur in the order shown. For example, two functions / steps shown in succession can in fact be executed substantially concurrently or even in reverse order. Depending on the functions / steps involved, this can be beneficial in certain circumstances.

[0061] Although only some of the embodiments of the present application have been described above with regard to the accompanying drawings, it will be appreciated by those skilled in the art that the present application can be implemented in many other forms without departing from the spirit and scope of the present application as defined by the appended claims. Therefore, the examples and embodiments shown are to be considered as illustrative and not restrictive, and the present application can encompass various modifications and alternatives without departing from the spirit and scope of the present application as defined by the appended claims.

Claims

1. A wearable device for skin testing, characterized in that, Comprising: a main body including a first fitting portion and a second fitting portion; a carrier liquid device fitted to the main body via the first fitting portion, and having a reaction area that contacts a subject skin of a wearer; an imaging device fitted to the main body via the second fitting portion, and configured to image the subject skin; a test paper assembly including: a mounting sheath that sheaths the reaction area of the carrier liquid device, and a test paper connected to the mounting sheath and capable of carrying a test reagent; and a limiting frame connected to the test paper and limiting a contact area of the test paper with the subject skin, wherein an imaging area of the subject skin imaged by the imaging device is the same as the contact area; and a processing device configured to judge a brain health level of the wearer according to an imaging result of the imaging device, wherein the processing device further includes: an extraction unit configured to extract feature information associated with the brain health level of the wearer based on the imaging result; a comparison unit configured to compare the extracted feature information with a predetermined threshold value; a judgment unit configured to judge the brain health level of the wearer according to a comparison result from the comparison unit, wherein the feature information is an area of the subject skin that is red and swollen due to the skin test in the imaging result, when an area of the area is less than a predetermined area threshold value, the brain health level of the wearer is judged to be at risk of disease, and when the area of the area is greater than the predetermined area threshold value, the brain health level of the wearer is judged to be healthy.

2. The wearable device according to claim 1, wherein the carrier liquid device is detachably fitted to the main body via the first fitting portion; and the imaging device is detachably fitted to the main body via the second fitting portion, wherein, when the imaging device is fitted to the main body via the second fitting portion, a sealed space is formed between the wearable device and the subject skin.

3. The wearable device according to claim 1, wherein the first fitting portion and the second fitting portion are the same portion in the main body.

4. The wearable device according to claim 1, wherein the first fitting portion and / or the second fitting portion is a cavity.

5. The wearable device of claim 1, wherein, the extraction unit is further configured to construct a color model based on the imaging result, and extract the feature information associated with the brain health level of the wearer based on image pixel color information in the color model.

6. The wearable device of claim 1, wherein, Further comprising: an output device configured to output the brain health level of the wearer judged by the processing device; and / or a communication device configured to send data outside the wearable device for processing or storage of the data, wherein the data includes the imaging result and / or the judged brain health level of the wearer.

7. The wearable device of claim 1, wherein, The brain health level of the wearer is a health level of the wearer with respect to mental and / or neurological diseases. The brain health level of the wearer is a health level of the wearer with respect to mental and / or neurological diseases.

8. The wearable device of claim 7, wherein, The psychiatric diseases include at least schizophrenia spectrum and other psychotic disorders, bipolar disorders, depressive disorders, anxiety disorders, trauma- and stressor-related disorders, and neurodevelopmental disorders; and / or The neurological diseases include at least stroke, posterior circulation ischemia, Parkinson’s disease, Parkinsonism, dementia, mild cognitive impairment.

9. The wearable device of claim 1, wherein, Also included are: a timing device configured to time from the start of contact of the test agent with the skin under test.

10. The wearable device of claim 9, wherein, Also included are: the timing device is further configured to issue a first instruction in response to the timing reaching a predetermined first time threshold, wherein the first instruction instructs the issuance of a reminder signal and / or instructs the unloading of the carrier liquid device from the subject.

11. The wearable device of claim 10, wherein, the timing device is further configured to issue a second instruction in response to the timing reaching a predetermined one or more second time thresholds, wherein the second instruction instructs the imaging device to image the skin under test.

12. The wearable device of claim 1, wherein, The test agent is an HCAR2 receptor activator or an HCAR3 receptor activator or an ester thereof.

13. The wearable device of claim 12, wherein, The test agent is nicotinic acid or a derivative thereof.

14. The wearable device of claim 13, wherein, The test agent is methyl nicotinate, ethyl nicotinate, or a combination thereof.

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