Sea cucumber fucoidan separation and purification device and method

Abstract

The application discloses a kind of sea cucumber fucoidan separation and purification device and method, belong to separation and purification technical field, between upper flower board and lower flower board are equipped with spindle-shaped centrifugal cylinder, centrifugal generating device is arranged in centrifugal cylinder, annular chamber of annular convex shape is formed in the waist of centrifugal cylinder, filter screen is arranged at the annular surface formed in the joint of annular chamber and inner chamber, ultrasonic transducer is evenly inserted into its inside along the circumferential direction on the upper end surface of annular chamber, annular vibration barrier is formed in annular chamber by ultrasonic transducer, one-way valve is arranged on the lower end surface of annular chamber, cooling rod can be magnetically attracted and combined and is evenly arranged on the circumferential outer edge of upper flower board and lower flower board, and cooling rod is embedded outside annular chamber simultaneously.Centrifugal classification and ultrasonic extraction are through interactive circulation, impurity mixture is separated from pure fucoidan by centrifugal effect, then fucoidan is further separated and handled by ultrasonic extraction, and high-purity low-molecular-weight fucoidan is obtained.

Description

TECHNICAL FIELD

[0001] The present application relates to a separation and purification device and method, in particular to a sea cucumber fucoidan separation and purification device and method. BACKGROUND

[0002] Fucoidan is a sulfated polysaccharide mainly found in brown seaweed, with various biological activities such as antioxidant, anti-inflammatory, antitumor, and anticoagulant. Fucoidan has a wide range of molecular weights, from a few thousand to a few million Daltons. Fucoidan of different molecular weights may have different biological activities and application values, so researchers are very interested in fucoidan of specific molecular weight range.

[0003] The low molecular weight part of fucoidan is mainly oligosaccharide and oligosaccharide, with a molecular weight of several thousand to several hundred thousand Daltons. High molecular weight fucoidan is generally composed of long polysaccharide chains, with a molecular weight of more than several million Daltons. The molecular weight of fucoidan may affect its biological activity and function. Current research shows that low molecular weight fucoidan is more easily absorbed and utilized by the body, and has better biological activity.

[0004] Currently, the main ways to degrade fucoidan macromolecules into small molecules are:

[0005] Hot water extraction method, fucoidan is heated with water to decompose into small molecules. This method can only extract extracellular polysaccharide, and the process is time-consuming and has low extraction rate.

[0006] Enzymatic extraction method, using cellulase and other enzymes to treat, so that the cell wall softens, swells and collapses, thereby changing the permeability of the cell wall and improving the extraction rate of the contents. However, since enzyme action requires optimal conditions, the extraction process requires strict control of pH, temperature, etc., which is difficult to operate and has high process requirements. SUMMARY

[0007] In order to solve the above technical problems, the present application provides a sea cucumber fucoidan separation and purification device and method.

[0008] In order to solve the above technical problems, the technical scheme adopted by the present application is: a sea cucumber fucoidan separation and purification device, which comprises an upper flower plate and a lower flower plate, a spindle-shaped centrifugal cylinder is vertically arranged between the upper flower plate and the lower flower plate, a centrifugal generating device is arranged in the centrifugal cylinder along the central axis of the inner chamber of the centrifugal cylinder, an annular chamber with a ring-shaped convex shape is formed at the waist of the centrifugal cylinder, a filter screen is arranged at the annular surface formed at the joint of the annular chamber and the inner chamber, a plurality of ultrasonic transducers are uniformly inserted into the inner part of the annular chamber along the circumferential direction at the upper end surface of the annular chamber, the plurality of ultrasonic transducers form an annular vibration barrier in the annular chamber, and a plurality of one-way valves are arranged at the lower end surface of the annular chamber, a plurality of magnetically attractable cooling rods are uniformly arranged along the circumferential direction outside the upper flower plate and the lower flower plate, and the plurality of cooling rods are simultaneously embedded outside the annular chamber.

[0009] Further, the upper flower plate and the lower flower plate are both planar plate bodies, and the shapes and sizes of the two are consistent, the outer edges of the annular chamber coincide with the outer edges of the upper flower plate and the lower flower plate, arc-shaped grooves are formed at a plurality of positions of the upper flower plate and the lower flower plate that are aligned with each other, the cooling rods are matched in the arc-shaped grooves, magnets are embedded in the groove walls of the arc-shaped grooves to magnetically attract the cooling rods made of iron-copper alloy, and embedding grooves are formed in the middle parts of the cooling rods and face the annular chamber, when the cooling rods are magnetically attracted in the arc-shaped grooves formed at the positions of the upper flower plate and the lower flower plate that are aligned with each other, the embedding grooves of the cooling rods form embedding with the annular chamber.

[0010] Further, the upper end surface and the lower end surface of the embedding groove are both planar, the spacing between the upper end surface and the lower end surface is greater than or equal to the height of the annular chamber, the upper end surface and the lower end surface of the embedding groove have arc-shaped contact surfaces matched with the side walls of the annular chamber, the arc-shaped contact surfaces and the side walls of the annular chamber form absorbing surfaces in combination, and the cooling rods and the arc-shaped grooves form outer diffusion surfaces in combination.

[0011] Further, a circular upper through hole is formed in the center of the upper flower plate, a circular lower through hole is formed in the center of the lower flower plate, the upper end part of the centrifugal cylinder is matched and arranged in the upper through hole, and the lower end part of the centrifugal cylinder is matched and arranged in the lower through hole formed in the lower flower plate, the upper through hole and the side wall of the upper end part, and the lower through hole and the side wall of the lower end part form inner diffusion surfaces in combination.

[0012] Further, a plurality of upper and lower penetrating heat dissipation holes are formed in the periphery of the upper through hole of the upper flower plate and the periphery of the lower through hole of the lower flower plate, and the heat dissipation holes are arranged in a radial direction of the upper flower plate and the lower flower plate.

[0013] Further, the plurality of one-way valves are respectively connected to the outside through independent output pipelines, and the output pipelines are downwardly arranged through the corresponding heat dissipation holes of the lower flower plate.

[0014] Further, the centrifugal generating device comprises a central roller matched with the shape of the inner chamber, the central roller is connected with a motor upward through a connecting roller, the circumferential surface of the central roller is provided with a plurality of inclined teeth, the plurality of inclined teeth are all inclined to the same side, the width between adjacent two inclined teeth gradually decreases from the middle of the central roller to the two ends, and the inclined teeth are horizontally aligned at the maximum width.

[0015] Further, the upper end surface of the connecting roller is flush with the upper end of the centrifugal cylinder, the gap between the connecting roller and the upper end forms an annular material inlet, and the lower end of the centrifugal cylinder forms a circular material outlet which is closed by an openable lower end cover.

[0016] Further, the diameter of the connecting roller gradually decreases from top to bottom, and a ring of inwardly converging rings is arranged along the inner edge of the upper end downward and inclined to the connecting roller, and the gap between the inwardly converging rings and the connecting roller communicates with the material inlet.

[0017] A separation and purification method of a sea cucumber fucoidan separation and purification device, the separation and purification method is the interactive circulation of centrifugal classification and ultrasonic extraction to realize the separation and purification of sea cucumber fucoidan, specifically comprising: the sea cucumber powder is fully hydrolyzed by the rotation and stirring action and centrifugal action of the centrifugal generating device, and is fully acted in the centrifugal field, a filter screen is arranged at the annular surface formed at the joint part of the ring chamber and the inner chamber, the solvent filtered by the filter screen is subjected to ultrasonic extraction through the annular vibration barrier formed by the eight ultrasonic transducers arranged uniformly in the ring chamber, the ultrasonic wave oscillates and breaks the high molecular weight fucoidan chain, promotes the release and dissolution of the fucoidan into low molecular weight fucoidan which is more easily absorbed and utilized by organisms, the local solvent convection is generated by the ultrasonic vibration, the periodic deformation and oscillation generated by the vibration fluctuation makes the molecules and particles in the solvent generate periodic displacement and change, promotes the solvent to form convection in the inner chamber and the ring chamber in the centrifugal process, so that the parts in the solvent are mixed with each other, and the process is repeated to improve the purity and efficiency of the separation and purification of sea cucumber fucoidan.

[0018] The application discloses a sea cucumber fucoidan separation and purification device and method, which has the following advantages:

[0019] I. Good separation and purification effect: the device can more effectively extract and separate fucoidan through the interaction of centrifugal classification and ultrasonic extraction. The centrifugal generating device can improve the dissolution and separation effect of the material, the filter screen can separate solid impurities, and the ultrasonic extraction can oscillate and break high molecular weight fucoidan, promote the release and dissolution of the fucoidan into low molecular weight fucoidan which is more easily absorbed and utilized by organisms.

[0020] II. Easy to operate: Compared with enzymatic extraction method, the device does not need to use exogenous enzyme, avoiding the operation difficulty and high process requirement of strict control of PH value, temperature and other conditions. At the same time, the device has simple structure and operation process, and the extraction process is relatively convenient.

[0021] III. High extraction efficiency: compared with hot water extraction method, sea cucumber fucoidan separation and purification method can realize the dissolution and separation of polysaccharide by ultrasonic extraction, so as to extract polysaccharide more effectively. Compared with the problems of long time and low extraction rate of hot water extraction method, sea cucumber fucoidan separation and purification method has higher extraction efficiency.

[0022] IV. Improve purity and quality: the device separates solid impurities through filter screen, ensuring the purity and quality of the solution entering the ring chamber. Ultrasonic extraction can break high molecular weight polysaccharide and separate low molecular weight polysaccharide which is more easily absorbed and utilized by organisms, so as to improve the purity and quality of the product.

[0023] V. Improve the stability of the device: by using cooling rod, upper flower plate and the design of upper flower plate; it can effectively reduce the temperature of the device, adjust the working temperature of separation and purification, and avoid the instability or overload work of equipment caused by overheating. Reduce the heat loss and thermal expansion of the equipment, so as to reduce the load and wear of the equipment. BRIEF DESCRIPTION OF DRAWINGS

[0024] Figure 1 It is a partial structure exploded view of the separation and purification device.

[0025] Figure 2 It is a structure diagram of the centrifugal device installed in the centrifugal cylinder.

[0026] Figure 3 It is a structure diagram of the ring chamber.

[0027] Figure 4 It is a structure diagram of the center roller.

[0028] Figure 5 It is a local structure diagram of the material inlet of the centrifugal cylinder.

[0029] Figure 6 It is a perspective view of the ring chamber.

[0030] Figure 7 It is a structure diagram of setting cooling rod between upper flower plate and lower flower plate.

[0031] Figure 8 It is a structure diagram of the installation relationship among upper flower plate, centrifugal cylinder and cooling rod.

[0032] Figure 9 It is a structure diagram of the present application.

[0033] In the figure: 1, upper flower plate; 2, lower flower plate; 3, centrifugal cylinder; 4, centrifugal generating device; 5, ultrasonic transducer; 6, one-way valve; 7, cooling rod; 8, arc-shaped groove; 9, magnet; 10, heat dissipation hole; 11, upper through hole; 21, lower through hole; 31, inner chamber; 32, ring chamber; 33, filter screen; 34, upper end portion; 35, lower end portion; 36, material inlet; 37, material outlet; 38, lower end cover; 39, inner collecting ring; 41, center roller; 42, connecting roller; 43, motor; 44, helical tooth; 61, output pipeline; 71, embedding groove; A, absorption surface; B, outer diffusion surface; C, inner diffusion surface. DETAILED DESCRIPTION

[0034] The present application will be further described in detail below in combination with the accompanying drawings and specific embodiments.

[0035] As shown in the sea cucumber fucoidan separation and purification device shown in Figure 1 and Figure 9 , it comprises an upper flower plate 1 and a lower flower plate 2, both of which are planar plate bodies with a certain thickness, and the shapes and sizes of the two are consistent, a spindle-shaped centrifugal cylinder 3 is vertically arranged between the upper flower plate 1 and the lower flower plate 2, a circular upper through hole 11 is formed in the center of the upper flower plate 1, a circular lower through hole 21 is formed in the center of the lower flower plate 2, the upper end portion 34 of the centrifugal cylinder 3 is matched and arranged in the upper through hole 11, and the lower end portion 35 of the centrifugal cylinder 3 is matched and arranged in the lower through hole 21 formed in the lower flower plate 2. A centrifugal generating device 4 is arranged in the centrifugal cylinder 3 along the central axis of the inner chamber 31 thereof, specifically, the centrifugal generating device 4 comprises a center roller 41 matched with the shape of the inner chamber 31, the center roller 41 is connected with a motor 43 through a connecting roller 42 upwardly, and the motor 43 can be suspended at a high place through a support.

[0036] As shown in the connecting roller 42 shown in Figure 2 , the upper end surface of the connecting roller 42 is flush with the upper end portion 34 of the centrifugal cylinder 3, an annular material inlet 36 is formed at the gap between the connecting roller 42 and the upper end portion 34, sea cucumber dry powder after crushing is added through the material inlet 36 and an appropriate amount of distilled water is injected as a buffer solvent, the lower end portion 35 of the centrifugal cylinder 3 forms a circular material outlet 37 for discharging impurity mixture, the material outlet 37 is closed by an openable lower end cover 38, and the openable manner of the lower end cover 38 is not limited to one, for example, the lower end cover 38 opens the material outlet 37 by rotating or twisting at the lower end portion 35 of the centrifugal cylinder 3, or the lower end cover 38 opens the material outlet 37 by hinging downwardly, which needs to cooperate with a clamping member to form a closed effect, or a more simple cooperation manner of the end cover 38 and the lower end portion 35 of the centrifugal cylinder 3 is adopted.

[0037] In this embodiment, as shown in Figure 3As shown, the annular chamber 32 with an annular convex shape is formed in the waist of the centrifugal cylinder, and the filter screen 33 is arranged at the annular surface formed at the joint of the annular chamber 32 and the inner chamber 31. Figure 4 As shown, the plurality of inclined teeth 44 are arranged on the circumferential surface of the central roller 41, and the plurality of inclined teeth 44 are all arranged to incline to the same side, the width between the adjacent two inclined teeth 44 gradually decreases from the middle of the central roller 41 to the two ends, and the inclined teeth 44 are horizontally aligned at the maximum width from the annular chamber of the centrifugal cylinder. Therefore, the centrifugal device functions to fully hydrolyze the sea cucumber powder through the rotating stirring action, and at the same time, the centrifugal action is generated and the maximum centrifugal force is applied to the annular chamber, and the fucoidan with different mass and size will exhibit different sedimentation rates in the centrifugal field, so as to realize the centrifugal classification of the molecular weight. Figures 1-4 As shown, the reason for generating the above-mentioned action is that:

[0038] I. The shape of the central roller 41 matches the spindle shape of the inner chamber 31, and the central roller 41 fills the space of the inner chamber 31 as much as possible without stirring dead angle, and the rotating stirring and centrifugal action can generate strong flow and shear effect between the roller and the inner chamber, so as to maximize the contact area between the sea cucumber powder and the solvent, promote the dissolution and reaction, and make the sea cucumber powder fully act in the centrifugal force field, thereby improving the dissolution and separation effect of the material.

[0039] II. The arrangement of the inclined teeth 44 of the central roller 41 and the convex shape of the annular chamber 32 make the centrifugal force more concentrated and generate stronger centrifugal effect, and at the same time, the width of the inclined teeth 44 also has a significant influence on the centrifugal force. When the width between the adjacent inclined teeth 44 increases, the centrifugal force will also increase accordingly. Since the inclined teeth 44 are horizontally aligned at the maximum width from the annular chamber 32, the inclined teeth 44 with larger width can provide greater centrifugal force.

[0040] In the embodiment, as shown, Figure 5 As shown, the diameter of the connecting roller 42 gradually decreases from top to bottom, and a set of inwardly converging rings 39 inclined to the connecting roller 42 are arranged along the inner edge of the upper end 34 downward, and the gap between the inwardly converging rings 39 and the connecting roller 42 is communicated with the material inlet 36. The diameter of the connecting roller 42 gradually decreases from top to bottom, and a set of inwardly converging rings 39 are arranged downward, and the gap between the inwardly converging rings 39 and the connecting roller 42 is communicated with the material inlet 36. The diameter of the connecting roller 42 gradually decreases from top to bottom to form a certain pressure gradient, guide the flow of the material, and promote the downward flow of the material and gradually enter the centrifugal cylinder 3 through the material inlet 36. The rotation of the connecting roller 42 is conducive to the re-dispersion and uniform falling of the material flow into the centrifugal cylinder 3, avoiding the accumulation and blockage phenomenon; and the gradually inclined inwardly converging rings 39 hinder the centrifuged material from leaking out in the opposite direction.

[0041] As shown, Figures 3-5As shown, with the centrifugal separation device continuously working, solid impurities can be precipitated or suspended in the solvent, and the solid impurities formed in the centrifugal process are separated out by the filtering effect of the filter screen 33, so as to ensure the purity and quality of the solution entering the annular chamber 32. It should be noted that the pore size of the filter screen can be selected as required to filter out the solid impurities that are not required, while retaining the fucoidan molecules that are required. The separated solid impurities are discharged through the material outlet 37, thereby improving the quality and purity of the product.

[0042] As shown in Figure 6 , eight ultrasonic transducers 5 are uniformly inserted into the inside of the annular chamber 32 at the upper end surface thereof in the circumferential direction. The ultrasonic transducers 5 are connected to an ultrasonic wave generating source. The filtered solvent passes through the annular vibration barrier formed by the eight ultrasonic transducers 5 in the annular chamber 32 to perform ultrasonic extraction, thereby improving the separation effect. The ultrasonic waves oscillate and break the fucoidan chains into high-molecular-weight fucoidan, thereby promoting the release and dissolution of the fucoidan into low-molecular-weight fucoidan that is more easily absorbed and utilized by organisms. The annular vibration barrier makes the solvent flow more uniform and stable during the centrifugal process. The ultrasonic vibration can generate local solvent convection. Periodic deformation and oscillation generated by the vibration fluctuation cause the molecules and particles in the solvent to produce periodic displacement and change, thereby promoting the formation of convection of the solvent during the centrifugal process, causing the parts of the solvent to mix with each other, making the flow of the solvent more uniform, and improving the purity and efficiency of the separation. Figure 3 As shown in , the annular vibration barrier removes the stubborn solid impurities remaining on the filter screen 33 by the vibration fluctuation force generated by the ultrasonic transducers, thereby avoiding clogging of the filter screen. During the centrifugal process, some solid impurities may accumulate in certain areas of the centrifugal cylinder, causing clogging and accumulation. The setting of the vibration barrier effectively disperses and precipitates these solid impurities, thereby ensuring normal operation of the device.

[0043] Figure 6 As shown in , a plurality of one-way valves 6 are arranged at the lower end surface of the annular chamber 32. The plurality of one-way valves 6 are each connected to the outside through an independent output pipeline 61. The purified sea cucumber fucoidan solvent is concentrated, and then freeze-dried to obtain solid sea cucumber fucoidan powder. The one-way valves can be manually or electrically operated. The output pipeline 61 is downwardly provided through the heat dissipation hole 10 corresponding thereto on the lower flower plate 2, thereby saving the space for pipeline arrangement.

[0044] Figure 7 As shown in Figure 1 , a plurality of cooling rods 7 that can be magnetically attracted and combined are uniformly arranged along the circumferential outer edge of the upper flower plate 1 and the lower flower plate 2. The plurality of cooling rods 7 are simultaneously embedded outside the annular chamber 32. Specifically, the outer edges of the annular chamber 32 coincide with the outer edges of the upper flower plate 1 and the lower flower plate 2, and the plurality of cooling rods 7 are arranged along the circumferential outer edges of the upper flower plate 1 and the lower flower plate 2.Figure 7 The arc-shaped slots 8 are arranged on the upper flower plate 1 and the lower flower plate 2 in a position aligned with each other, the cooling rod 7 is matched in the arc-shaped slots 8, the magnet 9 is embedded in the slot wall of the arc-shaped slots 8 to magnetically attract the cooling rod 7 made of iron-copper alloy, preferably, the upper flower plate 1 and the lower flower plate 2 are also made of iron-copper alloy, wherein the iron element in the iron-copper alloy can be magnetically attracted by the magnet 9, which makes the cooling rod 7 more convenient to disassemble, because it is arranged in a circumferential outer ring of the upper flower plate 1 and the lower flower plate 2, and such an arrangement can realize replacement of the cooling rod 7 during the working process of the device, the copper element in the iron-copper alloy has good heat dissipation performance, the embedding groove 71 is arranged in the middle of the cooling rod 7 and faces the direction of the ring chamber 32, the upper end face and the lower end face of the embedding groove 71 are both flat surfaces, the spacing between the upper end face and the lower end face is greater than or equal to the height of the ring chamber 32, so as to ensure that the cooling rod 7 provides installation space, the embedding groove 71 has an arc-shaped contact surface matched with the side wall of the ring chamber 32 between the upper end face and the lower end face, when the cooling rod 7 is magnetically attracted in the arc-shaped slots 8 arranged on the upper flower plate 1 and the lower flower plate 2 and aligned with each other, the embedding groove 71 of the cooling rod 7 is embedded in the ring chamber 32.

[0045] As shown in Figure 7 and Figure 8 The arc-shaped contact surface and the side wall of the ring chamber 32 form an absorption surface A, and the cooling rod 7 and the arc-shaped slot 8 form an outer diffusion surface B. The upper through hole 11 and the side wall of the upper end 34 form an inner diffusion surface C, and the lower through hole 21 and the side wall of the lower end 35 form an inner diffusion surface C. The cooling rod 7 will quickly conduct heat through the absorption surface A and the outer diffusion surface B, and the upper flower plate 1 and the lower flower plate 2, and the heat will be transferred from the inside of the device to the cooling rod 7 and the upper flower plate 1 and the lower flower plate 2, and the upper flower plate 1 and the lower flower plate 2 will also absorb the heat of the centrifugal cylinder 3 through the inner diffusion surface C, thereby increasing the surface area for heat exchange with the surrounding air or environment, which is conducive to heat dissipation. In practice, in order to accelerate heat dissipation, an external fan can be used to increase air flow.

[0046] In addition, a plurality of heat dissipation holes 10 are arranged on the periphery of the upper through hole 11 of the upper flower plate 1 and the lower through hole 21 of the lower flower plate 2, and the heat dissipation holes 10 are arranged in a radial direction of the upper flower plate 1 and the lower flower plate 2. The heat dissipation holes also increase the surface area, help heat dissipation, and at the same time, the air flow in the upper and lower directions is facilitated, which is conducive to heat dissipation of the barrel of the centrifugal cylinder 3.

[0047] The sea cucumber fucoidan separation and purification device disclosed in the application uses the interactive circulation of centrifugal classification and ultrasonic extraction to improve the separation effect.

[0048] The centrifugal generating device 4 can fully hydrolyze the sea cucumber powder by rotating stirring and centrifugal action, and make the sea cucumber powder fully act in the centrifugal field, so as to improve the dissolution and separation effect of the material. The filter screen 33 is arranged at the annular surface formed by the joint of the ring chamber 32 and the inner chamber 31, the filtered solvent is subjected to ultrasonic extraction in the ring chamber 32 by the annular vibration barrier formed by the eight ultrasonic transducers 5, the ultrasonic waves can oscillate and break the polysaccharide chain into high molecular weight fucoidan, promote the release and dissolution of the polysaccharide, and separate the polysaccharide into low molecular weight fucoidan which is easier to be absorbed and utilized by organisms, the ultrasonic vibration can generate local solvent convection, the periodic deformation and oscillation generated by the vibration fluctuation can make the molecules and particles in the solvent generate periodic displacement and change, so as to promote the solvent to form convection between the inner chamber 31 and the ring chamber 32 in the centrifugal process, make the parts in the solvent mix with each other, and repeatedly perform the process, so as to improve the purity and efficiency of the separation.

[0049] The above embodiments are not the limitation of the present application, and the present application is not limited to the above examples, the changes, modifications, additions or replacements made by the person skilled in the art within the technical solution range of the present application also belong to the protection scope of the present application.

Claims

1. A device for separating and purifying sea cucumber fucoidan, characterized in that: It includes the upper flower board (1) and the lower flower board (2), the spindle-shaped centrifugal cylinder (3) is vertically arranged between the upper flower board (1) and the lower flower board (2), the centrifugal generating device (4) is arranged in the centrifugal cylinder (3) along the central axis direction of the inner chamber (31) thereof, the annular chamber (32) with annular convex shape is formed at the waist of the centrifugal cylinder (3), the filter screen (33) is arranged at the annular surface formed at the joint of the annular chamber (32) and the inner chamber (31), a plurality of ultrasonic transducers (5) are uniformly inserted into the inner part of the annular chamber (32) along the circumferential direction of the upper end surface of the annular chamber (32), the annular vibration barrier is formed in the annular chamber (32) by the plurality of ultrasonic transducers (5), a plurality of one-way valves (6) are arranged on the lower end surface of the annular chamber (32), a plurality of cooling rods (7) capable of being magnetically attracted and combined are uniformly arranged along the circumferential direction outside the annular chamber (32), and the plurality of cooling rods (7) are simultaneously embedded outside the annular chamber (32); A circular upper through hole (11) is formed at the center of the upper flower board (1), a circular lower through hole (21) is formed at the center of the lower flower board (2), the upper end part (34) of the centrifugal cylinder (3) is matched and arranged in the upper through hole (11), the lower end part (35) of the centrifugal cylinder (3) is matched and arranged in the lower through hole (21) formed in the lower flower board (2), and the upper through hole (11) and the side wall of the upper end part (34) and the lower through hole (21) and the side wall of the lower end part (35) are combined to form an inner diffusion surface (C); The centrifugal generating device (4) comprises a central roller (41) matched with the shape of the inner chamber (31), the central roller (41) is connected with a motor (43) through a connecting roller (42) upwardly, the circumferential surface of the central roller (41) is provided with a plurality of inclined teeth (44), the plurality of inclined teeth (44) are all inclined to the same side, the width between the adjacent two inclined teeth (44) gradually decreases from the middle of the central roller (41) to the two ends, and the inclined teeth (44) are horizontally aligned at the maximum width apart.

2. The device according to claim 1, characterized in that: The upper flower board (1) and the lower flower board (2) are both planar panel bodies, and the shapes and sizes of the two are consistent, the outer edges of the annular chamber (32) coincide with the outer edges of the upper flower board (1) and the lower flower board (2) upwardly and downwardly, arc-shaped grooves (8) are formed at the positions of the upper flower board (1) and the lower flower board (2) which are upwardly and downwardly aligned with each other, the cooling rods (7) are matched in the arc-shaped grooves (8), the magnet (9) is embedded in the groove wall of the arc-shaped groove (8) to magnetically attract the cooling rods (7) made of iron-copper alloy, the embedding groove (71) is formed in the middle part of the cooling rod (7) and faces the annular chamber (32), and when the cooling rod (7) is magnetically attracted in the arc-shaped groove (8) formed in the upper flower board (1) and the lower flower board (2) which are upwardly and downwardly aligned with each other, the embedding groove (71) of the cooling rod (7) is embedded in the annular chamber (32).

3. The device according to claim 2, wherein the device is characterized by: The upper end face and the lower end face of the slot (71) are both flat surfaces, the distance between the upper end face and the lower end face is greater than or equal to the height of the ring chamber (32), the upper end face and the lower end face of the slot (71) have an arc-shaped contact surface matching the side wall of the ring chamber (32), the arc-shaped contact surface and the side wall of the ring chamber (32) form an absorption surface (A), and the cooling rod (7) and the arc-shaped slot (8) form an outer diffusion surface (B).

4. The device according to claim 1, characterized in that: A plurality of heat dissipation holes (10) are arranged on the periphery of the upper through hole (11) of the upper flower plate (1) and the periphery of the lower through hole (21) of the lower flower plate (2), and the heat dissipation holes (10) are arranged radially along the upper flower plate (1) and the lower flower plate (2).

5. The device according to claim 4, wherein the device is characterized by: The plurality of one-way valves (6) are each connected to the outside through an independent output pipeline (61) which is arranged downward from the corresponding heat dissipation hole (10) of the lower flower plate (2).

6. The device according to claim 1, characterized in that: The upper end face of the connecting roller (42) is flush with the upper end (34) of the centrifugal cylinder (3), the gap between the connecting roller (42) and the upper end (34) forms an annular material inlet (36), and the lower end (35) of the centrifugal cylinder (3) forms a circular material outlet (37) which is closed by an openable lower end cover (38).

7. The device according to claim 6, characterized in that: The diameter of the connecting roller (42) gradually decreases from top to bottom, and a set of inwardly converging rings (39) are arranged downward along the inner edge of the upper end (34) and inclined to the connecting roller (42), and the gap between the inwardly converging rings (39) and the connecting roller (42) communicates with the material inlet (36).

8. The separation and purification method of the sea cucumber fucoidan separation and purification device according to any one of claims 1-7, characterized in that, The separation and purification method is an interactive cycle of centrifugal classification and ultrasonic extraction to separate and purify sea cucumber fucoidan, which specifically includes: fully hydrolyzing sea cucumber powder by rotating stirring and centrifugal action of a centrifugal generator, and fully acting in a centrifugal field, an annular surface is formed at the joint of the ring chamber and the inner chamber, a filter screen is arranged at the annular surface, the solvent filtered by the filter screen is extracted by an annular vibration barrier formed by eight ultrasonic transducers arranged uniformly in the ring chamber, the ultrasonic waves oscillate and break the fucoidan chains into high molecular weight fucoidan, promote the release and dissolution of fucoidan into low molecular weight fucoidan which is more easily absorbed and utilized by organisms, the local solvent convection is generated by ultrasonic vibration, the periodic deformation and oscillation generated by the vibration fluctuation make the molecules and particles in the solvent produce periodic displacement and change, promote the solvent to form convection in the inner chamber and the ring chamber during the centrifugal process, and make the parts in the solvent mix with each other, so as to improve the purity and efficiency of the separation and purification of sea cucumber fucoidan.

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