Hydrocolloid dressings, methods of manufacture and use

Abstract

The present application relates to a hydrocolloid composition comprising a block copolymer, a plasticizer, a tackifying resin and a viscous polysaccharide. The hydrocolloid composition can be used to prepare a hydrocolloid dressing with higher liquid absorption and tack retention, and can remove old and worn-out keratin on the surface of the skin, and has excellent exfoliation effect.

Description

Technical Field

[0001] This invention relates to the field of biomedical technology, and in particular to a hydrocolloid composition, a hydrocolloid dressing, a method for preparing the hydrocolloid dressing, and its application. Background Technology

[0002] Factors such as harsh environmental conditions, unbalanced diet, irregular lifestyle, and emotional stress in daily life can slow down or disrupt metabolism. Metabolic problems can have negative effects on the body, including skin issues. Normally, the skin's surface undergoes weekly metabolism, causing dead skin cells to shed naturally. When metabolism slows down, excess dead skin cells accumulate, burdening the skin and leading to roughness and dullness.

[0003] Therefore, we often use exfoliating products to remove dead skin cells from the surface of the skin, which can effectively improve skin problems such as blemishes and dullness. Exfoliation involves using scrubs or strong cleansing products to remove the thick layer of dead skin cells from the face, essentially a softening and exfoliating process. However, currently available exfoliating scrubs with fine particles may not provide a suitable scrubbing feel for everyone due to individual skin types, and improper use can cause skin abrasions, redness, and swelling. Summary of the Invention

[0004] To address the aforementioned issues and effectively remove dead skin cells while reducing skin damage from exfoliating products, this application provides a novel hydrocolloid dressing product. Currently, there are no reports of such products.

[0005] Specifically, this application provides a hydrocolloid composition comprising a block copolymer, a plasticizer, a tackifying resin, and a viscous polysaccharide.

[0006] Furthermore, by weight, the block copolymer in the hydrocolloid composition is 32-50 parts, the plasticizer is 7-20 parts, the tackifying resin is 17-35 parts, and the viscous polysaccharide is 15-40 parts.

[0007] More preferably, by weight, the block copolymer in the hydrocolloid composition is 35-45 parts, the plasticizer is 15-20 parts, the tackifying resin is 25-35 parts, and the viscous polysaccharide is 20-30 parts.

[0008] Furthermore, in the hydrocolloid composition, the block copolymer includes styrene-isoprene-styrene block copolymer and / or styrene-butadiene-styrene block copolymer, preferably styrene-isoprene-styrene block copolymer.

[0009] Furthermore, in the hydrocolloid composition, the plasticizer is selected from one or more of mineral oil, white oil, dioctyl adipate or dioctyl phthalate, preferably mineral oil.

[0010] Furthermore, in the hydrocolloid composition, the tackifying resin is selected from C5 and / or C9 petroleum resins, preferably C5 petroleum resin.

[0011] Furthermore, in the hydrocolloid composition, the viscous polysaccharide includes one or more of hyaluronic acid, sodium carboxymethyl cellulose, and croscarmellose sodium.

[0012] Preferably, the molecular weight of the hyaluronic acid is 300,000 to 1,500,000 Da.

[0013] This application also provides a hydrocolloid dressing comprising any of the above-described hydrocolloid matrix compositions.

[0014] Furthermore, the dressing may also include other active ingredients and / or excipients.

[0015] This application also provides a method for preparing a hydrocolloid dressing, which includes the following preparation steps:

[0016] Step 1: Prepare a hydrocolloid substrate using the hydrocolloid composition provided in this application;

[0017] Step 2: Coat, shape, and cut the hydrocolloid substrate to obtain the dressing.

[0018] Further, in step one, the block copolymer, plasticizer, tackifying resin and viscous polysaccharide in the hydrocolloid composition are mixed evenly in a certain proportion to obtain the hydrocolloid substrate.

[0019] Further, in step one, the hydrocolloid composition is put into a kneader and kneaded at a temperature of 110–150°C.

[0020] Furthermore, in step two, the hydrocolloid substrate is extruded using a hot extruder and then coated.

[0021] Furthermore, in step two, the hydrocolloid substrate is bonded to the backing and hot melt adhesive film using a coating machine, and then shaped and cut.

[0022] This application also provides the use of the above-described hydrocolloid composition or dressing obtained by the preparation method in cosmetics, preferably in the preparation of exfoliating cosmetics or medical devices.

[0023] Invention Effects

[0024] The technical solution provided in this application can be used to obtain a hydrocolloid composition or dressing with high liquid absorption and adhesion, which can remove dead skin cells from the skin surface and has excellent exfoliation effect.

[0025] Furthermore, compared with the exfoliating products with abrasive particles commonly used in existing technologies, this hydrocolloid product adheres to human skin, has strong water retention and breathability, is non-irritating, reduces skin dryness, and will not cause problems such as scratches, irritation, or redness. It is also more widely compatible with users of various skin types. Attached Figure Description

[0026] Figure 1 The image shown is a picture of the hydrocolloid mask prepared in Example 1 before cutting.

[0027] Figure 2 The diagram shows a liquid absorption cup. Detailed Implementation

[0028] The present application will now be described in further detail with reference to specific embodiments. The embodiments given are intended to enable a more thorough understanding of the present application and to fully convey the scope of the present application to those skilled in the art.

[0029] It should be noted that certain terms are used in the specification and claims to refer to specific components. Those skilled in the art will understand that different terms may be used to refer to the same component. This specification and claims do not distinguish components based on differences in terminology, but rather on differences in function. The terms "comprising" or "including" used throughout the specification and claims are open-ended and should be interpreted as "comprising but not limited to." The following descriptions in the specification are preferred embodiments for carrying out this application; however, these descriptions are for the purpose of understanding the general principles of the specification and are not intended to limit the scope of this application. The scope of protection of this application shall be determined by the appended claims.

[0030] This application provides a hydrocolloid composition comprising a block copolymer, a plasticizer, a tackifying resin, and a viscous polysaccharide.

[0031] In one specific embodiment, the hydrocolloid composition comprises, by weight parts:

[0032] The block copolymer is 32 to 50 parts, for example 32 parts, 33 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 48 ​​parts, and 50 parts;

[0033] The plasticizer is 7 to 20 parts, for example, 7 parts, 8 parts, 10 parts, 12 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, or 20 parts;

[0034] The tackifying resin is 17 to 35 parts, for example, 17 parts, 18 parts, 20 parts, 22 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, and 35 parts;

[0035] The amount of viscous polysaccharide is 15 to 40 parts, for example, 15 parts, 18 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 32 parts, 35 parts, 38 parts, and 40 parts.

[0036] In a preferred embodiment, the hydrocolloid composition comprises, by weight, 32-45 parts of block copolymer, 7-20 parts of plasticizer, 20-30 parts of tackifying resin, and 25-40 parts of viscous polysaccharide.

[0037] In a preferred embodiment, the hydrocolloid composition comprises, by weight, 35-45 parts of block copolymer, 15-20 parts of plasticizer, 25-30 parts of tackifying resin, and 25-30 parts of viscous polysaccharide.

[0038] In a preferred embodiment, the hydrocolloid composition contains, by weight percentage, 32-50 wt% of the block copolymer, 7-20 wt% of the plasticizer, 17-35 wt% of the tackifying resin, and 15-40 wt% of the viscous polysaccharide.

[0039] In a preferred embodiment, the hydrocolloid composition contains, by weight percentage, 35-45 wt% of the block copolymer, 15-20 wt% of the plasticizer, 25-30 wt% of the tackifying resin, and 25-30 wt% of the viscous polysaccharide.

[0040] In this application, wt% represents the weight percentage, that is, the proportion of the weight of the component to the total weight of the composition.

[0041] The hydrocolloid composition described in this application is a component of hydrocolloid materials or products. Hydrocolloid materials are made by mixing particles of water-soluble / water-swellable polymers with rubber. Common hydrocolloid materials are medical hydrocolloid samples, which are samples processed by mixing elastic polymeric hydrogels with synthetic rubber and viscous substances.

[0042] The thermoplastic block copolymer described in this application is a novel polymer material intermediate between rubber and resin. It possesses the excellent properties of traditional cross-linked vulcanized rubber, such as high elasticity, aging resistance, and oil resistance, while also having the advantages of ordinary plastics, such as ease of processing and wide range of processing methods. Furthermore, its environmentally friendly and non-toxic characteristics make it a globally standardized environmentally friendly material.

[0043] In one specific embodiment, the block copolymer in the hydrocolloid composition may include styrene-isoprene-styrene block copolymer and / or styrene-butadiene-styrene block copolymer, preferably styrene-isoprene-styrene block copolymer.

[0044] The plasticizer described in this application is a substance added to a polymer system to increase the plasticity of the polymer system. The increase in plasticity is mainly manifested in a decrease in hardness, modulus, softening temperature, and brittleness; and an increase in elongation, flexibility, and toughness.

[0045] In one specific embodiment, the plasticizer in the hydrocolloid composition is selected from one or more of mineral oil, white oil, dioctyl adipate or dioctyl phthalate, preferably mineral oil.

[0046] The mineral oil described in this application is generally a base oil refined from petroleum through physical distillation. After useful light substances are fractionated during crude oil refining, the remaining bottom oil is further refined. Mineral oils often possess excellent chemical stability, do not corrode textile fibers, and can increase the brightness and smoothness of products; therefore, they can be used as plasticizers in natural rubber.

[0047] The tackifying resins described in this application refer to small molecule compounds that can improve the tackiness of rubber materials, especially surface tackiness. They are divided into two main categories: natural products and their derivatives, and synthetic resins. Natural resins include rosin (gum rosin, tall oil rosin, wood rosin), rosin derivatives (hydrogenated rosin, disproportionated rosin, polymerized rosin, esterified rosin, maleic acid rosin), and terpene resins (α-terpene resin, β-terpene resin, terpene phenolic resin), etc. Synthetic resins include polymeric resins (C5, C9 and C5 / C9 petroleum resins, dicyclopentadiene (DCPD) resin, coumarone-indene resin, styrene series resins), and condensation resins (alkylphenolic resins, xylene resin), etc. Tackifying resins are generally used as compounding agents to increase polymer adhesion, improve initial tack, and reduce operating or processing viscosity.

[0048] In one specific embodiment, the thickening resin in the hydrocolloid composition is selected from C5 and / or C9 petroleum resins, preferably C5 petroleum resin.

[0049] The viscous polysaccharide described in this application is glycosaminoglycan, abbreviated as GAGs, which is a general term for the polysaccharide portion of a proteoglycan macromolecule.

[0050] In one specific embodiment, the viscous polysaccharide in the hydrocolloid composition is one or more of hyaluronic acid, sodium carboxymethyl cellulose, and cross-linked sodium carboxymethyl cellulose.

[0051] The hyaluronic acid described in this application is an acidic mucopolysaccharide that exhibits a variety of important physiological functions in the body due to its unique molecular structure and physicochemical properties, such as lubricating joints, regulating vascular permeability, regulating protein and electrolyte diffusion and transport, and promoting wound healing. Most importantly, hyaluronic acid has a special water-retention effect and is currently considered the best moisturizing substance found in nature, earning it the title of an ideal natural moisturizing factor.

[0052] The hyaluronic acid mentioned in this application refers to hyaluronic acid salts or their derivatives, including one or more of sodium hyaluronate, potassium hyaluronate, zinc hyaluronate, magnesium hyaluronate, calcium hyaluronate, and acetylated hyaluronic acid.

[0053] Sodium carboxymethyl cellulose (CMC) described in this application is a carboxymethylated derivative of cellulose, also known as cellulose gum. It is an anionic cellulose ether and can be used as a thickener, stabilizer, and emulsifier.

[0054] In one specific embodiment, the molecular weight of the hyaluronic acid is 300,000 to 1,500,000 Da, for example, 300,000, 500,000, 800,000, 1,000,000, or 1,200,000 Da.

[0055] This application also provides a hydrocolloid dressing comprising any of the above-described hydrocolloid compositions.

[0056] In one specific embodiment, the dressing may further include active ingredients and / or excipients.

[0057] In some specific embodiments, the active ingredient may be an ingredient with whitening, wrinkle-reducing, repairing, or anti-aging functions.

[0058] In some specific embodiments, the excipients may be polyols (including but not limited to butanediol, glycerol, propylene glycol, sorbitol, hexanediol, etc.), inorganic salts, and other excipients that can be selected in the dressing field.

[0059] In some specific embodiments, the dressing also includes glycerol.

[0060] This application also provides a method for preparing a dressing, which includes the following preparation steps:

[0061] Step 1: Prepare a hydrocolloid substrate using the hydrocolloid composition provided in this application;

[0062] Step 2: Coat, shape, and cut the hydrocolloid substrate to obtain the dressing.

[0063] In one specific embodiment, step one is: mixing the block copolymer, plasticizer, tackifying resin, and viscous polysaccharide in the hydrocolloid composition in a certain proportion, and kneading them in a kneader to obtain a hydrocolloid substrate.

[0064] In a preferred embodiment, based on a total weight of 100 parts by weight of the block copolymer, plasticizer, tackifying resin, and viscous polysaccharide, the block copolymer comprises 32-50 parts by weight, the plasticizer comprises 7-20 parts by weight, the tackifying resin comprises 15-35 parts by weight, and the viscous polysaccharide comprises 15-40 parts by weight.

[0065] In one specific embodiment, the reaction temperature during the kneading process is 110°C to 150°C. The specific kneading process is not limited in this application, and can be referred to the conventional kneading process in the art. For example, during the kneading process, thermoplastic elastomer and plasticizer are added at a temperature of 110°C to 150°C until they are mixed evenly, tackifying resin is added at a temperature of 120°C to 150°C until they are mixed evenly, and viscous polysaccharide is added at a temperature of 110°C to 120°C.

[0066] In one specific embodiment, during the kneading process, a thermoplastic elastomer and a plasticizer are added at a temperature of 140°C, a tackifying resin is added when the temperature is lowered to 130°C, and a viscous polysaccharide is added when the temperature is lowered to 110°C.

[0067] In one specific embodiment, the block copolymer includes styrene-isoprene-styrene block copolymer and / or styrene-butadiene-styrene block copolymer, the plasticizer is selected from one or more of mineral oil, white oil, dioctyl adipate or dioctyl phthalate, the tackifying resin is selected from C5 or C9 petroleum resin, and the viscous polysaccharide is one or more of hyaluronic acid, sodium carboxymethyl cellulose, and cross-linked sodium carboxymethyl cellulose.

[0068] In one specific embodiment, the block copolymer is a styrene-isoprene-styrene block copolymer, the plasticizer is mineral oil, the tackifying resin is C5 petroleum resin, and the viscous polysaccharide is hyaluronic acid.

[0069] In one specific embodiment, step two includes extruding the hydrocolloid substrate through a hot extruder and then coating it.

[0070] In one specific embodiment, step two includes bonding the hydrocolloid substrate to the backing and hot melt adhesive film using a coating machine, followed by shaping and cutting.

[0071] In one specific embodiment, the backing is glassine paper or release paper.

[0072] In one specific embodiment, the hot melt adhesive film is a polyurethane hot melt adhesive film.

[0073] This application also provides the use of the above-described hydrocolloid composition or the dressing or the dressing obtained by the preparation method in cosmetics, preferably in the preparation of cosmetics with exfoliating effects.

[0074] The hydrocolloid dressing provided in this application adheres well to human skin, is non-irritating, moisturizes and reduces skin dryness, and effectively avoids the problem of similar exfoliating products easily scratching the skin. The hyaluronic acid it contains effectively softens the stratum corneum of the skin surface, improving the exfoliation effect.

[0075] Example

[0076] This application provides a general and / or specific description of the materials and test methods used in the experiments. In the following examples, unless otherwise specified, % represents wt%, i.e., weight percentage. Reagents or instruments used, unless otherwise specified, are all commercially available conventional reagent products.

[0077] Example 1: Preparation of hydrocolloid dressing

[0078] Preheat the kneader to 140℃, add 600g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 300g of mineral oil, knead for 45 minutes, then cool to 130℃, add 400g of C5 petroleum resin, cool to 110℃ after 30 minutes, add 450g of sodium carboxymethyl cellulose and 50g of sodium hyaluronate (molecular weight 300,000), and after 30 minutes, extrude through a hot extruder. Then, bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it into shape. The dressing composition is shown in Table 1.

[0079] Example 2: Preparation of hydrocolloid dressing

[0080] Preheat the kneader to 140℃, add 600g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 300g of mineral oil, knead for 45 minutes, then cool to 130℃, add 400g of C5 petroleum resin, cool to 110℃ after 30 minutes, add 500g of sodium carboxymethyl cellulose, and after 30 minutes, extrude through a hot extruder. Then, bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it to shape. The composition of the dressing is shown in Table 1.

[0081] Example 3: Preparation of hydrocolloid dressing

[0082] Preheat the kneader to 140℃, add 600g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 300g of mineral oil, knead for 45 minutes, then cool to 130℃, add 400g of C5 petroleum resin, cool to 110℃ after 30 minutes, add 500g of sodium hyaluronate (molecular weight 300,000), and after 30 minutes, extrude through a hot extruder. Then, bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it to shape. The dressing composition is shown in Table 1.

[0083] Example 4: Preparation of hydrocolloid dressing

[0084] Preheat the kneader to 140℃, add 600g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 300g of mineral oil, knead for 45 minutes, then cool to 130℃, add 400g of C9 petroleum resin, cool to 110℃ after 30 minutes, add 450g of sodium carboxymethyl cellulose and 50g of sodium hyaluronate (molecular weight 300,000), and after 30 minutes, extrude through a hot extruder. Then, bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it into shape. The dressing composition is shown in Table 1.

[0085] Example 5

[0086] Preheat the kneader to 140℃, add 600g of styrene-butadiene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 300g of mineral oil, knead for 45 minutes, then cool to 130℃, add 400g of C5 petroleum resin, cool to 110℃ after 30 minutes, add 450g of sodium carboxymethyl cellulose and 50g of sodium hyaluronate (molecular weight 300,000), and after 30 minutes, extrude through a hot extruder. Then, bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it into shape. The dressing composition is shown in Table 1.

[0087] Example 6

[0088] Preheat the kneader to 140℃, add 600g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 300g of white oil, knead for 45 minutes, then cool to 130℃, add 400g of C5 petroleum resin, cool to 110℃ after 30 minutes, add 450g of sodium carboxymethyl cellulose and 50g of sodium hyaluronate (molecular weight 300,000), and after 30 minutes, extrude through a hot extruder. Then, bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it into shape. The dressing composition is shown in Table 1.

[0089] Example 7: Preparation of hydrocolloid dressing

[0090] Preheat the kneader to 140℃, add 600g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 300g of mineral oil, knead for 45 minutes, then cool to 130℃, add 460g of C5 petroleum resin, cool to 110℃ after 30 minutes, add 450g of sodium carboxymethyl cellulose and 57.5g of sodium hyaluronate (molecular weight 300,000), and after 30 minutes, extrude through a hot extruder. Then, bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it into shape. The dressing composition is shown in Table 1.

[0091] Example 8: Preparation of hydrocolloid dressing

[0092] Preheat the kneader to 140℃, add 600g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 300g of mineral oil, knead for 45 minutes, then cool to 130℃, add 400g of C5 petroleum resin, cool to 110℃ after 30 minutes, add 450g of sodium carboxymethyl cellulose and 50g of hyaluronic acid (molecular weight 1.5 million), after 30 minutes, extrude through a hot extruder, then bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it into shape. The composition of the dressing is shown in Table 1.

[0093] Example 9: Preparation of hydrocolloid dressing

[0094] Preheat the kneader to 140℃, add 720g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 140g of mineral oil, knead for 45 minutes, then cool to 130℃, add 360g of C5 petroleum resin, cool to 110℃ after 30 minutes, add 522g of sodium carboxymethyl cellulose and 58g of sodium hyaluronate (molecular weight 300,000), after 30 minutes, extrude through a hot extruder, then bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it into shape. The composition of the dressing is shown in Table 1.

[0095] Example 10: Preparation of hydrocolloid dressing

[0096] Preheat the kneader to 140℃, add 900g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 300g of mineral oil, knead for 45 minutes, then cool to 130℃, add 350g of C5 petroleum resin, cool to 110℃ after 30 minutes, add 225g of sodium carboxymethyl cellulose and 25g of sodium hyaluronate (molecular weight 300,000), and after 30 minutes, extrude through a hot extruder. Then, bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it into shape. The dressing composition is shown in Table 1.

[0097] Example 11 Preparation of hydrocolloid dressing

[0098] Preheat the kneader to 120°C, add 600g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 10 minutes, then add 300g of mineral oil, knead for 60 minutes, then cool to 110°C, add 400g of C5 petroleum resin, cool to 100°C after 30 minutes, add 450g of sodium carboxymethyl cellulose and 50g of sodium hyaluronate (molecular weight 300,000), and after 30 minutes, extrude through a hot extruder. Then, bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it into shape. The dressing composition is shown in Table 1.

[0099] Comparative Example 1: Preparation of Hydrocolloid Dressing

[0100] Preheat the kneader to 140℃, add 324g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 270g of mineral oil, knead for 45 minutes, then cool to 130℃, add 432g of C5 petroleum resin, cool to 110℃ after 30 minutes, add 697g of sodium carboxymethyl cellulose and 77g of sodium hyaluronate (molecular weight 300,000), and after 30 minutes, extrude through a hot extruder. Then, bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it into shape. The dressing composition is shown in Table 1.

[0101] Comparative Example 2: Preparation of Hydrocolloid Dressing

[0102] Preheat the kneader to 140℃, add 600g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 300g of mineral oil, knead for 45 minutes, then cool to 130℃, add 200g of C5 petroleum resin, cool to 110℃ after 30 minutes, add 450g of sodium carboxymethyl cellulose and 50g of sodium hyaluronate (molecular weight 300,000), and after 30 minutes, extrude through a hot extruder. Then, bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it into shape. The dressing composition is shown in Table 1.

[0103] Comparative Example 3: Preparation of Hydrocolloid Dressing

[0104] Preheat the kneader to 140℃, add 600g of styrene-isoprene-styrene block copolymer thermoplastic elastomer to the kneader, heat for 5 minutes, then add 300g of mineral oil, knead for 45 minutes, then cool to 130℃, add 400g of C5 petroleum resin, cool to 110℃ after 30 minutes, add 150g of sodium carboxymethyl cellulose, and after 30 minutes, extrude through a hot extruder. Then, bond the backing and hot melt adhesive film on a coating machine to form the final shape, and finally cut it to shape. The composition of the dressing is shown in Table 1.

[0105] Table 1. Composition of Hydrocolloid Dressings (Unit: g)

[0106]

[0107]

[0108] Subsequent evaluation experiments were conducted using the hydrocolloid dressings prepared in Examples 1-11 and Comparative Examples 1-3.

[0109] Experiment Example 1: Liquid Absorption Assessment Experiment

[0110] Experimental instruments: constant temperature oven, hygrometer, liquid absorption cup, electronic balance.

[0111] Experimental Method: Cut dressing samples of the same size to fit snugly on the testing instrument to prevent leakage. If the sample has a liner, remove it, ensuring the wound-contact surface of the sample is facing inwards against the upper flange of the cylinder. Place the clamping ring on the outer surface of the sample and secure it. Weigh the cylinder together with the clamp (W1). Invert the cylinder and add approximately 20 mL of test solution (8.298 g sodium chloride and 0.368 g calcium chloride dihydrate dissolved in deionized water and diluted to 1 L in a volumetric flask) using a suitable pipette. Install the metal cap and weigh again (W2). Place the assembled cylinder in an oven (37°C, relative humidity RH below 20%). After 1 hour, remove each cylinder from the incubator and allow it to equilibrate at room temperature for 30 minutes, then weigh again (W3). Remove the metal caps from each cylinder and gently pour out the liquid, allowing the cylinder to drain in the inverted position for (15±2) minutes. Weigh the cylinder again along with all its components (including the sample) (W4).

[0112] Calculation formula: W = (W2 - W3) + (W4 - W1)

[0113] In the formula: W represents the liquid absorption of the sample, (W2-W3) is the mass of water vapor lost by the sample, and (W4-W1) is the mass of liquid absorbed by the material.

[0114] During the experiment, maintain the relative humidity (RH) in the drying oven or incubator below 20%.

[0115] The experimental results are shown in Table 2.

[0116] Table 2 Results of Liquid Absorption Capacity Experiment

[0117]

[0118]

[0119] The higher the liquid absorption capacity of a product, the stronger its water retention and breathability, resulting in greater comfort during use, softening of the stratum corneum, and greater ease of exfoliation. As can be seen from the experimental results in Table 2, all examples exhibited good liquid absorption capacity.

[0120] Experiment Example 2: Tackiness Evaluation Experiment

[0121] Experimental apparatus: tack tester, roller.

[0122] Experimental Method: Before the experiment, lay the hydrocolloid dressing sample flat on the operating table for 24 hours to allow it to acclimate. Remove the backing layer of the dressing sample before the test, taking care not to soil the adhesive surface during the test. If the width of the test sample is less than 25 mm, use the entire width; if the width of the test sample is greater than 25 mm, cut a 25 mm wide sample and test immediately after cutting. For highly elastic products, attach a non-stretchable adhesive tape of the same width to the back of the sample. Place the adhesive surface of one end of the prepared sample into contact with the clean surface of the stainless steel plate, aligning the entire width of the sample end with a distance of 25 mm from the end face of the steel plate, and ensuring that both sides of the sample are parallel to the long side of the steel plate. The unattached end of the sample should hang outside the end face of the steel plate. When attaching the sample, ensure that there are no air bubbles between the sample and the steel plate. Apply pressure to the attached portion of the sample with a roller, rolling it four times along the length of the sample at a speed of approximately 60 cm / min, and then allow it to rest at standard atmospheric pressure for 10 minutes. Mark a line on the end of the sample. Attach a weight of 0.8 N (80 g) per centimeter of the sample's suspension end, ensuring the force is evenly distributed across the entire width. Suspend the steel plate in a 36℃~38℃ hot air oven, tilting it 2° to the vertical to prevent the sample from peeling off and to allow the weight to remain suspended. Measure the time required for the sample to slip off the stainless steel plate. Experimental data are shown in Table 3.

[0123] Table 3 Results of the tack test

[0124] Width of the test sample (mm) Suspension weight (g) Time required to slide down (min) Example 1 25 200 82 Example 2 25 200 79 Example 3 25 200 85 Example 4 25 200 71 Example 5 25 200 81 Example 6 25 200 72 Example 7 25 200 94 Example 8 25 200 84 Example 9 25 200 73 Example 10 25 200 62 Example 11 25 200 73 Comparative Example 1 25 200 12 Comparative Example 2 25 200 39 Comparative Example 3 25 200 86

[0125] The product has high stickiness, and the stronger the adhesion, the stronger the exfoliation ability. As can be seen from the experimental results in Table 3, the sliding time required for the embodiments of the present invention is more than 60 minutes. Although Comparative Example 1 has a better liquid absorption capacity, the sliding time is only 12 minutes.

[0126] Experiment 3: Exfoliation Experiment

[0127] Experimental subjects: 120 volunteers aged 25-55 were selected. All volunteers had dry skin, rough skin or thickened stratum corneum. They were divided into 6 groups with 20 people in each group.

[0128] Experimental Methods: After cleansing their faces with a neutral facial cleanser, volunteers took photos using a VISIA facial image analyzer to record the amount of keratinocytes before use. Every night before bed, volunteers cleansed their faces with a neutral facial cleanser and then applied the samples prepared in Examples 1, 9-10, and Comparative Examples 1-3 to their faces for 20 minutes. After 15 consecutive days of use, volunteers took photos using a VISIA facial image analyzer to record the amount of keratinocytes after use.

[0129] The keratin content (Pi) of each volunteer's skin during sample use was calculated using the following formula:

[0130] Pi = (Number of keratinized skin cells after use × 100%) / (Number of keratinized skin cells before use)

[0131] The test results are shown in Table 4.

[0132] Table 4 Exfoliation Test Results

[0133] Pi (%) Example 1 66.9 Example 9 69.6 Example 10 68.3 Comparative Example 1 89.4 Comparative Example 2 83.1 Comparative Example 3 86.7

[0134] As can be seen from the experimental results in Table 4, the exfoliation effect of Examples 1 and 9-10 of the present invention is significantly higher than that of the comparative examples, and can reduce the amount of keratin by more than 30%.

[0135] The above description is merely a preferred embodiment of this application and is not intended to limit the application in any way. Any person skilled in the art may make changes or modifications to the disclosed technical content to create equivalent embodiments. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of this application, without departing from the scope of the technical solution of this application, shall still fall within the protection scope of this application.

Claims

1. A hydrocolloid composition, wherein, The hydrocolloid composition comprises 32-50 parts of block copolymer, 7-20 parts of plasticizer, 17-35 parts of tackifying resin, and 15-40 parts of viscous polysaccharide, and The block copolymer includes styrene-isoprene-styrene block copolymer and / or styrene-butadiene-styrene block copolymer, the plasticizer includes one or more of mineral oil, white oil, dioctyl adipate or dioctyl phthalate, the tackifying resin includes C5 and / or C9 petroleum resin, and the viscous polysaccharide includes one or more of hyaluronic acid, sodium carboxymethyl cellulose, and cross-linked sodium carboxymethyl cellulose.

2. A hydrocolloid dressing comprising the hydrocolloid composition of claim 1.

3. A method for preparing a hydrocolloid dressing, which is prepared through the following steps: Step 1: Prepare a hydrocolloid substrate using the hydrocolloid composition according to claim 1; Step 2: Coat, shape, and cut the hydrocolloid substrate to obtain the hydrocolloid dressing.

4. The preparation method according to claim 3, wherein, In step one, the hydrocolloid composition is added to a kneader and mixed evenly, and then kneaded at a kneading temperature of 110℃~150℃.

5. The preparation method according to claim 3 or 4, wherein, In step two, the hydrocolloid substrate is extruded through a hot extruder and then bonded to the backing and hot melt adhesive film through a coating machine to form the final product.

6. The use of the hydrocolloid composition of claim 1, the hydrocolloid dressing of claim 2, or the hydrocolloid dressing obtained by any one of claims 3 to 5 in the preparation of exfoliating cosmetics or medical devices.

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