Parallel-probed microcirculation monitoring device

Abstract

The embodiment of the specification provides a parallel detection microcirculation monitoring device, which is used for tongue bottom microcirculation monitoring and comprises a sublingual microcirculation detection body and an imaging and image processing part which is arranged separately from the sublingual microcirculation detection body, wherein the sublingual microcirculation detection body and the imaging and image processing part are connected through a flexible optical fiber; the sublingual microcirculation detection body comprises a detection head body which at least comprises a parallel structure detection head, the parallel structure detection head is used for extending towards the tongue bottom of a user so that the surface of the first side part of the parallel structure detection head is in surface contact with the tongue bottom; and the imaging and image processing part is used for receiving light information transmitted by the flexible optical fiber, amplifying the light information and imaging.

Description

[0001] Divisional Statement

[0002] The present application is a divisional application of the Chinese application with the application date of November 04, 2021, the application number of CN202180006004.9, and the invention name of "Microcirculation monitoring device with parallel detection and / or hook type optical fiber transmission", which claims the priority of the Chinese application with the application number of CN2020112180354, filed on November 04, 2020, the content of which is incorporated herein by reference in its entirety. TECHNICAL FIELD

[0003] The present application belongs to the field of microcirculation monitoring design, and particularly relates to a microcirculation monitoring device with parallel detection and / or hook type optical fiber transmission. BACKGROUND

[0004] Microcirculation refers to the blood circulation between arterioles and venules. By monitoring microcirculation, the material exchange between blood and tissue can be known. Sublingual microcirculation gradually attracts attention in clinical application due to its bedside convenience and non-invasiveness. The current microcirculation monitoring methods used in clinical application mainly include orthogonal polarization spectrum technology, lateral flow dark field imaging technology, laser Doppler imaging technology, near-infrared spectral imaging technology, pulse oximetry monitoring technology, and laser scanning confocal microscope technology. The current microcirculation monitoring methods need to be handheld by the operator during work, which causes various limitations, such as physiological shaking of the operator's hand to produce invalid images, inability to be handheld for a long time, and possible compression of the patient's sublingual tongue to affect comfort.

[0005] Therefore, the present specification provides a microcirculation monitoring device with parallel detection, which does not squeeze the tissue and does not have strong pressure on small venules with thin vessel walls, thereby avoiding mechanical obstruction of microcirculation blood flow. SUMMARY

[0006] One of the embodiments of the present specification provides a microcirculation monitoring device with parallel detection, which is used for sublingual microcirculation monitoring, and characterized in that the device comprises a sublingual microcirculation detection body and an imaging and image processing part which is detachably arranged with the sublingual microcirculation detection body, wherein the sublingual circulation detection body and the imaging and image processing part are connected through a flexible optical fiber; the sublingual microcirculation detection body comprises a detection head body, and the detection head body at least comprises a parallel structure detection head, the parallel structure detection head is used to extend towards the user's tongue base, so that the surface of the first side of the parallel structure detection head is in surface contact with the tongue base; the imaging and image processing part is used to receive the light information transmitted by the flexible optical fiber, amplify and image the light information.

[0007] In some embodiments, a receiving space is formed in the probe head body, and a light source and an ultrathin lens are arranged in the receiving space, the light source is used to irradiate the microcirculation area to be measured under the tongue, and the ultrathin lens is used to collect scattered light of the microcirculation area to be measured under the tongue and couple the light information in the scattered light into the flexible optical fiber.

[0008] In some embodiments, at least one segment of the probe head body is curved in a hook shape to form a hook structure that can be hung on the user's teeth.

[0009] In some embodiments, the probe head body is sleeved with a probe sleeve, and the probe sleeve is bionic and rounded in the contact part with the user's tongue.

[0010] In some embodiments, the length of the probe sleeve is determined based on different users.

[0011] In some embodiments, a longitudinal opening is arranged in the middle part of the probe sleeve, the probe sleeve is longitudinally sleeved on the probe head body, and the probe sleeve is further provided with a clamping structure for fixing or separating from the probe head body.

[0012] In some embodiments, the ultrathin lens comprises at least one super unit arranged on the surface, and the at least one super unit is used to receive the scattered light, wherein the super units are arranged in different materials and / or shapes according to phase compensation.

[0013] In some embodiments, an optical isolation area is arranged at the front end of the probe head body, incident light and reflected light generated on the surface under the tongue cannot enter the optical isolation area, and the optical isolation area comprises one or more isolation areas arranged near the light source in the probe head body according to the shape of the probe head body.

[0014] In some embodiments, two or more light sources are arranged on the side wall of the front end of the probe head body in a transverse or longitudinal arrangement, the light sources at different positions are controlled to work, and the angle of the light sources with the horizontal direction is adjusted to adapt to different users.

[0015] In some embodiments, the light source is a green light source absorbed by red blood cells.

[0016] The beneficial effects of the present application include but are not limited to:

[0017] The hook type microcirculation monitoring device of parallel detection in the embodiment of the present application is aimed at the problem that the existing microcirculation monitoring handheld device is pressed against the sublingual area of the patient during detection, which is likely to cause bleeding and seriously affect the imaging quality, by arranging the light source and the ultra-thin lens on the side wall of the detection head, the detection head can be horizontally inserted during the detection of the tongue bottom microcirculation, so that the sublingual tissue is not pressed, the comfort of the user is improved, high-quality tongue bottom microcirculation information is collected, and the accuracy of the microcirculation monitoring area is improved.

[0018] The hook type microcirculation monitoring device of parallel detection in the embodiment of the present application is aimed at the problem that the existing microcirculation monitoring device is large in size and heavy in quality, is pressed against the sublingual area of the patient during detection, and affects the microcirculation imaging quality, by arranging the detection head separately from the imaging and image processing part and connecting them through a flexible optical fiber to transmit light information, the size and weight of the detection body can be greatly reduced, the detection head occupies too much space in the sublingual area and causes compression to the sublingual area is avoided, and the accuracy and repeatable detection of the continuous microcirculation monitoring area are greatly improved.

[0019] The hook type microcirculation monitoring device of parallel detection in the embodiment of the present application is aimed at the problem that the existing microcirculation monitoring device is based on handheld operation, the device is large in size, the detection head body is hard, the unintentional shaking of the operator is likely to cause injury to the sublingual area, and the operator is extremely inconvenient to hold the device for a long time, so that continuous microcirculation detection cannot be realized, by designing the detection head into a hook shape, the detection head can be hung on the teeth of the user, and the sublingual microcirculation detection can be performed without holding the detection head body, so that the hands of the operator are freed and long-time stable and continuous microcirculation monitoring is facilitated.

[0020] The hook type microcirculation monitoring device of parallel detection in the embodiment of the present application is designed with different specifications and lengths of the probe sleeve according to different user groups, the front end of the detection head body is sleeved with the probe sleeve, and the part of the probe sleeve in contact with the sublingual area of the user is designed as a biomimetic tongue bottom rounded arc surface, so that the damage of the detection body to the sublingual area is effectively avoided.

[0021] The hook type microcirculation monitoring device of parallel detection in the embodiment of the present application is aimed at the problem that the traditional microcirculation monitoring instrument is large in size and heavy in weight, has high requirements for environmental stability, and cannot realize continuous and uninterrupted long-time monitoring, by using an ultra-structured lens with small size and light weight to replace the traditional optical glass lens, the focusing effect and achromatic effect are realized by using the structure, size and arrangement mode of the super unit at each position on the surface of the ultra-structured lens, and the problems of thick and heavy structure and complex design of the traditional optical lens are effectively solved. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure 1A schematic view of a hook type microcirculation monitoring device for parallel detection according to an embodiment of the present application;

[0023] Figure 2 A schematic view of tongue bottom microcirculation imaging according to an embodiment of the present application;

[0024] Figure 3 A schematic view of a tongue bottom microcirculation detection body with a probe sleeve according to an embodiment of the present application;

[0025] Figure 4 A schematic view of a probe sleeve according to an embodiment of the present application;

[0026] Figure 5 A schematic view of a tongue bottom microcirculation detection body according to an embodiment of the present application.

[0027] BRIEF DESCRIPTION OF DRAWINGS

[0028] 100: tongue bottom microcirculation detection body; 101: light source; 102: ultra-thin lens; 103: flexible optical fiber; 104: probe sleeve; 1041: clamping structure; 105: mirror; 106: optical isolation area; 107: focusing assembly; 108: signal receiving end; 200: imaging and image processing unit; 201: optical lens group; 202: motorized assembly; 203: imaging array. DETAILED DESCRIPTION

[0029] The present application provides a hook type microcirculation monitoring device for parallel detection, which will be further described in detail below in combination with the drawings and specific embodiments. The advantages and features of the present application will be more apparent according to the following description and claims.

[0030] The existing microcirculation monitoring handheld device has the problems of large volume of the front detection part, heavy overall detection instrument, only 20 seconds of monitoring time each time, inability to realize continuous uninterrupted long-term monitoring, high requirement for the operator, close tongue bottom of the detection head body, easy to squeeze the mucosa and subcutaneous blood vessels, far tongue bottom of the detection head body, affecting the quality of collected video, difficult to be consistent with the observation field of view of the split-time detection, and inability to continuously monitor and analyze the microcirculation of the same part for a long time. The present application provides a light tongue bottom microcirculation monitoring device, which sets the light source and the ultra-thin lens for collecting light on the side wall of the detection head, makes the detection part parallel to the tongue bottom instead of perpendicular to the tongue bottom, reduces the pressure on the mucosa and subcutaneous blood vessels of the patient's tongue bottom, and designs the detection head into a hook type, which can be hung on the tooth body, without the need for handheld, to realize continuous long-term tongue bottom microcirculation monitoring. Here, the continuity refers to the continuity of time and the continuity of the monitoring area.

[0031] Specifically, most of the patients in clinical anesthesia state are in supine position, and the operation time is usually from half an hour to several hours. During this period, how to stably and continuously monitor the microcirculation becomes the primary problem to be solved. In addition to improving the microcirculation monitoring instrument, we plan to use the patient's own anatomical structure, such as teeth and gums, to fix the microcirculation monitoring instrument. Therefore, the hook-like structure is very important. Due to the design of optical instruments, the innovation made by the applicant is very important. The traditional optical lens is like the lens in a single-lens reflex camera, and the weight and size can be imagined. In the hook structure with a very small inner diameter (such as 8mm) in the present application, the lens structure for focusing the light beam is a microlens based on a superstructure surface, which is composed of a silicon cell array that can accurately control the reflected light amplitude and phase information, thereby fundamentally greatly reducing the weight of the probe and the tongue bottom microcirculation exploration device with the hook sensor structure, reducing the pressure on the patient's sublingual blood vessels, and avoiding the problem that the probe easily causes sublingual bleeding. The following will be specifically and in detail.

[0032] Optical fibers play an important role in medical imaging, sensing and laser treatment due to their excellent signal transmission capability. Among them, the present application applies optical fiber technology to the microcirculation monitoring handheld device. The principle of application is: according to the total internal reflection of light at the interface between the core and the cladding, the transmission of light from the outside to the inside is realized, and the affected area is illuminated; then through the probe head body, the reflected light from the tissue surface is collected, and the processing system at the rear is transmitted through the optical fiber to realize imaging. Based on this, the parallel detection hook type microcirculation monitoring device in the embodiment adopts optical fiber for light signal transmission, separates the probe head from the imaging and image processing part. When working, as long as the small probe head wrapped with optical fiber is hung on the user's teeth, the probe is fixed relative to the sublingual, and the devices related to imaging, signal image processing, etc. are set separately from the probe head and placed externally, connected by optical fiber, which is more flexible and portable than handheld monitoring instruments.

[0033] The applicant first proposes to separate the probe from the imaging and signal image processing devices in the industry. The microcirculation monitoring device is mainly used in emergency department (ED), intensive care unit (ICU) and anesthesia department perioperative management. Microcirculation is mainly composed of branch network of arteriole, capillary and venule. The lumen diameter of large arteriole and venule is less than about 100 μm. The small blood vessel network (lumen diameter is 0-20 μm) composed of capillary and post-capillary venule is the basic unit of oxygen exchange between blood and tissue. The lumen diameter of medium-sized blood vessels composed of pre-capillary arteriole and post-capillary venule is about 20 to 50 μm. The analysis of microcirculation flow is usually focused on 0-20 μm blood vessels. Since the mucosal tissue of microcirculation imaging is usually low contrast, the dynamic range required for analyzing the image is about 6-7 bits, and the peak performance of the imaging brightness in the existing product is the artifact of specular reflection, such as along the boundary of the salivary bubble, or along the mucosal surface with poor contact with the front end of the probe. Under low light intensity, the sensor response is nonlinear, and the signal-to-noise ratio is worse than the average or high light intensity. Therefore, when making a specific product, the light intensity, focusing and stability must be considered, and in use, bubbles or contaminated saliva between the probe and the patient's mucosa can easily block the light path and form light scattering interference or affect other blood vessel imaging. Therefore, the traditional microcirculation monitoring device can only collect and process images under the existing light intensity and focusing conditions, and further hope to analyze the blood flow of the blood vessel segment. Considering the error, stability and other conditions of light imaging, the existing probe and imaging, signal image processing can only be set together, and cannot be separated.

[0034] Embodiment one

[0035] The hook type microcirculation monitoring device of parallel detection in the embodiment comprises a sublingual microcirculation detection body, an imaging and image processing part which is separately arranged with the sublingual microcirculation detection body, and the sublingual microcirculation detection body is connected with the imaging and image processing part through a flexible optical fiber. The sublingual microcirculation detection body comprises a detection head body, at least one section of the detection head body is curved and forms a hook structure which can be hung on the teeth of a user. The detection head body comprises a parallel structure detection head and a hook part which can be hung on the teeth of a user. The parallel structure detection head is used to extend towards the tongue bottom of the user so that the surface of the first side of the parallel structure detection head forms a surface contact with the tongue bottom. A receiving space is formed in the detection head body, and a light source and an ultrathin lens are arranged in the receiving space. The light source is used to irradiate the sublingual microcirculation area to be detected, and the ultrathin lens is used to collect scattered light rays, and the light information in the scattered light rays is coupled into the flexible optical fiber after passing through the imaging channel. The ultrathin lens is arranged in the receiving space and located on the second side opposite to the first side. The ultrathin lens comprises a plurality of super unit cells arranged on the surface. The plurality of super unit cells are used to receive the scattered light rays which enter the receiving space through the surface of the parallel structure detection head and contain the microcirculation information of the tongue bottom. The super unit cells are arranged in different materials and / or shapes according to phase compensation to realize the achromatic and / or focusing functions of the scattered light rays.

[0036] The imaging and image processing part is signal connected with the flexible optical fiber, receives the light information transmitted by the flexible optical fiber, amplifies and images the light information, and outputs the image data of the sublingual microcirculation.

[0037] When the sublingual microcirculation is monitored, the detection head body is hung on the teeth of the user, and the parallel structure detection head extends towards the tongue bottom of the user so that the surface of the first side forms a surface contact with the tongue bottom. The light source emits a detection light beam to the surface of the sublingual tissue, the ultrathin lens collects the light rays which are scattered and absorbed in the tissue after entering the receiving space, focuses the light rays into a light beam along the space direction of the receiving space, and continuously transmits the light beam to the imaging and image processing part through the flexible optical fiber, so as to process the image data of the sublingual microcirculation which can be continuously monitored.

[0038] The parallel detection in the embodiment is that the side surface of the detection head forms a large-area surface contact with the tongue bottom without extruding the tissue. The parallel is relative to the tongue bottom, and the main difference is that the end of the existing detection head directly extrudes the tissue of the tongue bottom. In particular, when the user applies excessive pressure to the tissue, the microcirculation blood vessels are mechanically blocked, and the stability of the blood flow in the medium and / or large blood vessels is destroyed. The small veins with thin walls are more sensitive to pressure and can be used as an indicator of iatrogenic pressure. The "parallel detection" in the embodiment is that the side surface of the detection head forms a large-area surface contact with the tongue bottom without extruding the tissue, so that the small veins with thin walls are not subjected to strong pressure and the microcirculation blood vessels are not mechanically blocked.

[0039] The tongue sublingual microcirculation detection body in the embodiment is a hook type structure, which can be hung on the user's teeth. The tongue sublingual microcirculation detection body is detachably connected to the imaging and image processing unit at the rear end. For example, the tongue sublingual microcirculation detection body is connected to the imaging and image processing unit at the rear end through a transceiver, so that the tongue sublingual microcirculation detection body and the imaging and image processing unit at the rear end can be arranged separately. In clinical detection, it can also be transmitted to multiple rear-end imaging and image processing units for processing and display. In addition, considering the differences in the application population during the use of the tongue sublingual microcirculation detection body, tongue sublingual microcirculation detection bodies of different sizes can be provided. Different users use different sizes of tongue sublingual microcirculation detection bodies. Similarly, the present application can transmit different specifications of tongue sublingual microcirculation detection bodies being used to the same rear-end imaging and image processing unit for processing.

[0040] Please refer to Figure 1 The front end of the tongue sublingual microcirculation detection body 100 in the embodiment is provided with a parallel structure detection head, which is used to extend towards the user's tongue bottom to form a surface contact with the tongue bottom of the first side of the parallel structure detection head. A receiving space is formed in the detection head body, and a light source 101 and an ultrathin lens 102 are arranged in the receiving space. The light source 101 is used to irradiate the tongue sublingual microcirculation to be detected, and the ultrathin lens is used to collect the scattered light rays of the tongue sublingual microcirculation, and the light information in the scattered light rays is coupled into the flexible optical fiber through the imaging channel. The ultrathin lens 102 is arranged in the receiving space and located on the second side opposite to the first side. In this way, the detection part of the parallel structure detection head is parallel to the tongue sublingual microcirculation, rather than perpendicular, thereby reducing the pressure on the sublingual mucosa and subcutaneous blood vessels of the patient. When detecting the tongue bottom microcirculation, after the tongue sublingual microcirculation detection body is hung on the user's teeth, the position can be adjusted so that the light source of the parallel structure detection head is placed below the tongue bottom to be detected.

[0041] The tongue sublingual microcirculation detection body 100 (or the detection head body) in the embodiment at least includes a front end, a middle section and a rear end. The part that can contact with the user's tongue tissue is defined as the front end of the detection head body, and the middle section and the rear end also have the function of being held by medical staff. The tongue sublingual microcirculation detection body 100 (or the detection head body) is a hollow tube, and an imaging receiving channel can be formed in the tube. In the present example, the tube body of the detection head body can be integrally formed, or the front end, the middle section and the rear end can be formed separately. The front end, the middle section and the rear end can be integrally formed into a hook structure, which is hung on the user's teeth (such as teeth, gums, etc.) during use, and then fixed in position by medical tape.

[0042] The front end of the detection head body is provided with a light source 101 and an ultrathin lens 102, and the inside of the detection head body is provided with a flexible optical fiber 103 which is optically connected with the ultrathin lens 102 and used to conduct light signals.

[0043] The light source 101 can be used to provide incident light with a wavelength λ, where λ > 0. Specifically, the "light" emitted by the light source 101 includes, but is not limited to, pulsed xenon arc or lamp, mercury arc or lamp, halogen light or lamp, tungsten arc or lamp, laser, laser diode or light-emitting diode (LED). The "light" can also be classified as coherent or non-coherent, so the light source can be a coherent light source or a non-coherent light source. In a specific implementation, the wavelength λ of the incident light provided by the light source is determined by the absorption spectrum of hemoglobin and deoxyhemoglobin in the microcirculation. In the absorption spectrum of hemoglobin and deoxyhemoglobin, 420 nm, 550 nm and 800 nm are the isosbestic points of hemoglobin and deoxyhemoglobin. The wavelength of the incident light provided by the light source in this embodiment is 530 nm, but is not limited to 530 nm, and can also be 540 nm, 550 nm, etc.

[0044] The light source 101 not only refers to one light source, but also can be a plurality of light source assemblies. In this embodiment, the light source can be arranged on the side wall of the front end of the probe head body, that is, the light source is arranged at the end of the end that contacts the underside of the tongue, and is slightly spaced from the part that contacts the underside of the tongue, mainly to facilitate the illumination beam provided by the light source to be projected onto the tissue surface including the underside of the tongue.

[0045] A common practice is to open a plurality of holes in the shell of the probe head body, and the light source assemblies are respectively arranged in the holes, and the light source assemblies that can provide the illumination beam are arranged at an angle with the horizontal. This embodiment can have the following processing schemes. For example, the light sources of the light source assemblies are arranged in a horizontal or vertical queue on the side wall of the front end of the probe head body, and according to the differences in the underside of different people's tongues, the system can control the light sources at different positions to work, thereby improving the applicability of the probe head to the population. For another example, the angle of the light source assembly with the horizontal is adjustable, and during the microcirculation detection process, the medical operator can set and adjust the angle, so that the illumination angle of the illumination beam provided is adjustable. The light penetration depth can be related to the incident angle of the light, so that by adjusting the incident angle of the incident light, microcirculation images at different depths in the human tissue can be obtained.

[0046] It should be further noted that the light source mentioned in this embodiment is a relatively broad concept, which not only includes a narrow sense of light source, but also includes a broad sense of light source. The broad sense of light source refers to not only the light source generating part that provides the illumination beam, but also the light processing part that performs secondary processing on the generated light beam to have a better incident light effect. For example, it also includes a condenser lens for converging and collimating the incident light.

[0047] Because of the dispersion phenomenon of the optical material of the optical lens in the traditional microcirculation measuring instrument, the optical characteristics of the material change with the wavelength, which leads to the chromatic aberration of the optical element. The chromatic aberration problem seriously affects the accuracy and effect of the optical system working in different wave bands, especially in the color imaging of the visible light wave band, such as the wave band of about 530 nanometers to 550 nanometers in the microcirculation measuring instrument. The traditional optical design is to paste multiple lenses with different dispersion properties and different curved surface shapes together to realize the achromatism for several discrete wavelengths, so that the approximate achromatism effect of a relatively wide band can be obtained.

[0048] However, the traditional optical lens is relatively thick and heavy, with a thickness of 10 mm. In addition, multiple lenses with different dispersion properties and different curved surface shapes need to be pasted together, so that the volume of the microcirculation handheld detection device is very large. When the tongue bottom is detected, the tongue bottom is easily pressed, which seriously affects the detection effect and reduces the experience of the patient.

[0049] In view of the above problems, the present embodiment adopts a superstructure lens composed of a superstructure surface as a kind of ultra-thin lens to solve the problems of thick and heavy structure and complex design of the traditional optical system. The biggest advantage of the superstructure lens is thin and easy to integrate, and the chromatic aberration problem can be solved by arranging the electromagnetic material units in the imaging effect. The function is to refract light, instead of the traditional spherical lens to realize image magnification. In the tongue bottom microcirculation device, the thick and heavy traditional spherical lens can be effectively replaced to realize the tongue bottom microcirculation signal acquisition, and the wavelength of the incident light in the application is 530 nm to 560 nm.

[0050] The following briefly introduces how to design the superstructure lens and the design method:

[0051] In order to refract light like a spherical lens, the superstructure lens should satisfy the phase profile

[0052]

[0053] Where λ d is the designed wavelength, x and y are the position coordinates of each nanometer unit, and f is the focal length.

[0054] The phase profile is obtained by rotating an angle θ nf (x,y) at the given coordinates (x,y).

[0055] Because there is Therefore, the rotation angle θ nf (x,y) of each nanometer unit should satisfy

[0056]

[0057] The metasurface utilizes the birefringence property of a single nano-cell to function as a sub-wavelength half-wave plate. This is achieved by designing an asymmetric cross-section of the nano-cell with height, width, and length parameters that induce birefringence. The rotation angle θ of each nano-cell is determined by the formula (1) as follows: nf (x, y) is obtained according to formula (2).

[0058] The thickness of the metasurface lens in this embodiment is about 30 microns (only an example, not limited to the present application), and by designing the structure, size, and arrangement of the metasurface unit at each position on the surface of the metasurface lens, the required arbitrary phase distribution can be accurately obtained. The phase of the metasurface lens is divided into two parts: one part is the wavelength-independent basic phase, which corresponds to the focusing effect; the other part is the wavelength-dependent compensation phase, which corresponds to the chromatic aberration effect. The former can be achieved by using a geometric phase; the latter can be obtained by using a resonance phase of an integrated resonance unit.

[0059] Specifically, the metasurface lens includes a plurality of metasurface units arranged on the surface thereof for receiving scattered light containing tongue base microcirculation information. Moreover, the plurality of metasurface units are arranged in different materials and different shapes according to the phase compensation requirement to realize achromatic focusing function.

[0060] The metasurface unit can be a dielectric column, which is any one of a cylindrical body, a cuboid, a prism, or a cone. The metasurface unit can be a dielectric groove, which is a cylindrical body with a groove structure or a prismatic body with a groove structure or a cuboid with a groove structure. Whether it is a dielectric column or a dielectric groove, it is integrated with a battery resonance element inside to compensate for the phase of chromatic aberration.

[0061] According to the actual application requirement, only the dielectric column type metasurface unit can be arranged on the surface of the metasurface lens, only the dielectric groove type metasurface unit can be arranged, or both the dielectric column type and the dielectric groove type metasurface units can be arranged. The surface of the metasurface lens can be provided with metasurface units of various shapes, such as a cuboid dielectric column, a cylindrical dielectric column, a prismatic dielectric column, and a prismatic dielectric groove. In actual application, the dielectric column and the dielectric groove can be arranged in a concentric circle staggered manner or in a row and column parallel manner, or can be arranged irregularly according to the requirement. In addition, the shape and size of the dielectric column and the dielectric groove can also be changed according to the requirement, and the surface of the metasurface lens can simultaneously exist a plurality of dielectric columns or dielectric grooves with different structures and sizes.

[0062] The embodiment uses gallium nitride material transparent in green light band to process super unit, uses medium column and medium groove with different length-width size, and higher working efficiency is obtained compared with reflection system, and the phase curve is proportional to frequency, and the introduction of the medium groove can further enhance the phase compensation and higher working efficiency provided by the super unit. The phase compensation, working efficiency and the magnetic field distribution of the high-order resonance mode supported by the super unit form a continuous broadband super lens covering the green light band. When the numerical aperture is 0.106 mm, the super lens can realize achromatic focusing effect, and in the working wave band of green light, the incident parallel light can be focused to the same focal point (the designed focal length is 235 μm), and different numerical aperture green light super lenses can also be prepared to realize achromatic focusing effect. The efficiency of these green light super lenses will exceed 40%, and the focal point half-width of these green light super lenses will be an important measurement index, and whether they are close to the diffraction limit λ / 2NA can be judged, wherein λ is the wavelength of the incident light, and NA represents the numerical aperture, and it can be proved whether the prepared green light super lens is ideal.

[0063] According to actual application, different size medium column structures and super unit with phase curve proportional to frequency can be used to improve working efficiency and obtain phase compensation caused by chromatic aberration. In addition, different size medium groove structures are introduced, and greater phase compensation value can be obtained. This design based on high-order guided wave resonance breaks through the limitation of previous metal rod based plasmon resonance, so that the integrated resonance principle can be realized in the all-dielectric system, which opens up a wider practical space in the development of continuous microcirculation measurement instruments and other medical diagnosis and treatment instruments and equipment.

[0064] The at least one curved segment of the probe head body in the embodiment forms a hook structure, when the sublingual microcirculation is monitored, the front end of the probe head body contacts with the sublingual tissue, and the sublingual microcirculation probe is positioned on the tooth body adapted to the detection position of the sublingual tissue through the hook structure; the hook part of the hook structure is a flexible structure, so that the hook width of the hook part can be adjusted to adapt to the tooth body of the user, or the hook part can be adjusted in the position of the probe head body, so as to adjust the distance between the front end of the probe head body and the sublingual tissue.

[0065] When the sublingual tissue pre-detection position is determined, a tooth body that fits the position can be found. The present application not only realizes accurate positioning of the detection position through the position of the tooth body. A healthy adult normal dentition contains 32 permanent teeth, which are divided into four regions of upper and lower left and right, and are divided into incisors, canines, bicuspid teeth (premolars), and molars according to the morphology and function of the teeth, a total of 16 pairs. The left and right paired homonymous teeth have the same anatomical morphology. The tooth body includes three calcified hard tissues of enamel, dentin, and cementum, and a pulp cavity containing the pulp soft tissue. Each tooth body is composed of a tooth crown, a tooth neck, and a tooth root. For example, when a patient performs sublingual microcirculation monitoring, a certain canine position of this detection record can be recorded. The next time sublingual microcirculation monitoring is performed, the sublingual tissue pre-detection position of the last detection can be easily obtained. If the record is on the same canine, the possibility of detecting the same sublingual tissue pre-detection position is greatly enhanced. Therefore, the tooth body not only serves as a fixing function, but also serves as a position marker function. In addition, it can be directly recorded on the tooth crown, and if the old person does not have teeth, it can also be recorded on the tooth root.

[0066] The hook part of the hook type structure is a flexible structure. Specifically, the middle part of the probe head body can be provided with

[0067] The flexible body has a certain bending degree, such as using a corresponding material to have this property. A flexible body with a certain bending degree can also be provided on the middle part of the probe head body. The flexible body can have a certain width, which is convenient for bending and easy to hang on the tooth body.

[0068] The position of the hook part on the probe head body can be adjusted. The flexible structure can be bent into a hook part, and the bending position can be adjusted. As long as the distance between the front end of the probe head body and the sublingual tissue can be contacted, the distance can be adjusted. In addition, the present application can adjust the hook width and / or depth of the hook part, so that the hook part fits the tooth body of the user, and is convenient for fixing.

[0069] When microcirculation detection is performed, the tooth body that fits the sublingual tissue pre-detection position is found, the hook type structure is adjusted at the position to achieve that the front end of the probe head body (parallel structure probe head) can contact the sublingual tissue, the hook width of the hook part that fits the tooth body of the user is adjusted, the hook type structure is hung on the fitted tooth body, the light beam of the light source is projected onto the surface of the sublingual tissue, the ultra-thin lens collects the light rays scattered inside the tissue and returned to the surface of the tissue, and focuses the light beam to transmit the light ray information to the rear end imaging and image processing part through the flexible optical fiber to process into sublingual microcirculation image data.

[0070] The imaging and image processing unit 200 includes an optical lens group 201, a motion assembly 202, and an imaging array 203. The optical lens group 201 is used to further amplify the optical information transmitted through the flexible optical fiber, facilitating the imaging of the optical information onto the imaging array 203. The motion assembly 202 is used to adjust the image focusing and magnification. Of course, image processing can also be performed using a computer to generate sublingual microcirculation image data.

[0071] This embodiment introduces flexible optical fibers to separate the heavy lens assembly, the large imaging array, and the probe head. In practical applications, a transmission fiber bundle with high performance, such as low fiber breakage rate, low black fiber rate, and low crosstalk rate, can be selected to ensure high-quality image transmission. The fibers at both ends of the transmission fiber bundle are arranged sequentially to ensure the consistency between the transmitted and received images. For an image of the sublingual microcirculation vessels obtained by the sublingual microcirculation monitoring device in this embodiment, please refer to [the relevant documentation / reference]. Figure 2 The microcirculatory blood vessels in the image are clearly visible, and the imaging effect is good.

[0072] The probe body in this embodiment can be manufactured by 3D printing, and the material can be a resin polymer.

[0073] To further enhance user comfort, this embodiment incorporates a probe sleeve, such as... Figure 3 , Figure 4 As shown. The probe sleeve 104 is fitted onto the probe head body, and the contact area between the probe sleeve 104 and the user's tongue is a biomimetic rounded arc shape.

[0074] The shape of the probe sleeve 104 matches the hook-type structure of the probe head body. A longitudinal opening is provided in the middle to facilitate the longitudinal fitting of the probe sleeve 104 onto the probe head body. The probe sleeve 104 is also provided with a locking structure 1041 for fixing the probe head body and for easy disassembly of the probe head body.

[0075] This embodiment designs probe sleeves 104 of different specifications and lengths to cater to different user groups, such as... Figure 4 As shown. Probe sleeve a, with a front end length of 1.5cm, is suitable for sublingual microcirculation detection in children; probe sleeve b, with a front end length of 2cm, is suitable for sublingual microcirculation detection in adult women; probe sleeve c, with a front end length of 2.5cm, is suitable for sublingual microcirculation detection in adult men.

[0076] The sublingual microcirculation probe in the embodiment can be directly hung and fixed on the teeth of a user, has the characteristics of small volume and light weight, can avoid occupying too much space under the tongue and pressing the tongue, improves the comfort of the patient, and avoids the shaking of the handheld monitoring system of the doctor. Since the parallel structure probe head is parallel to the tongue bottom instead of being perpendicular to the tongue bottom, too much pressure is not applied to the tongue bottom, and the impact and pressure of the current cylindrical probe on the tongue bottom are effectively avoided. Compared with the handheld sublingual microcirculation monitoring device, the probe only needs to be sleeved on the teeth of the user, and other systems such as imaging processing are integrated into the rear end of the instrument. In this way, the weight of the instrument that needs to be manually controlled is greatly reduced, the working burden of the operator is greatly reduced, and stable, convenient and practical continuous sublingual microcirculation monitoring is achieved.

[0077] In use, the sublingual microcirculation probe of the present application can be sold separately. One rear-end image processing unit can be matched with multiple sublingual microcirculation probes. Therefore, the present application also protects a hook-type sublingual microcirculation probe, which comprises:

[0078] The probe head body is provided with a parallel structure probe head at the front end, a microcirculation signal collector is arranged on the side wall of the parallel structure probe head, a flexible optical fiber is arranged in the probe head body, the flexible optical fiber is connected with the microcirculation signal collector, the microcirculation signal collector is provided with a light source for projecting a light beam onto the surface of the sublingual tissue of the user and an ultrathin lens for collecting light rays scattered and absorbed by the inside of the tissue, and the ultrathin lens satisfies the condition that the spot diameter of the light rays after convergence is smaller than the inner diameter of the flexible optical fiber; at least one curved portion of the sublingual microcirculation probe is formed into a hook structure that can be hung on the teeth of the user.

[0079] At least one curved portion of the sublingual microcirculation probe is formed into a hook structure, when the sublingual microcirculation is monitored, the probe head body and the parallel structure probe head are placed under the tongue, and the sublingual microcirculation probe is positioned and arranged on the teeth at the pre-detection position of the sublingual tissue through the hook structure; the hook portion of the hook structure is a flexible structure, so that the hook width of the hook portion can be adjusted to adapt to the teeth of the user, or the hook portion can be adjusted at the position of the probe head body, so as to adjust the distance between the front end of the probe head body and the sublingual tissue.

[0080] An optical fiber coupler for optical signal transmission is arranged in the rear end of the probe head body, and the optical fiber coupler is connected with the flexible optical fiber.

[0081] The hook structure further comprises a probe sleeve, the probe sleeve is sleeved on the front end of the probe head body, and the contact part of the probe sleeve with the sublingual tissue of the user is in the form of a bionic tongue round arc surface.

[0082] In practical application, please refer to Figure 5The detection head body of the hook-type sublingual microcirculation detector includes a light source 101, a mirror 105, an ultrathin lens 102, and a signal receiving end 108. When detecting the microcirculation, the detection head body is inserted into the sublingual cavity in parallel, the light source 101 is aimed at the part to be monitored on the tongue bottom, the light source 101 projects a light beam to the part to be monitored, the light beam is scattered and absorbed by the tissue in the part to be monitored, and then is projected to the mirror 105. The mirror 105 can fold the light path and realize 90° turning of the light path. After being reflected by the mirror 105, the light is projected to the ultrathin lens 102. The ultrathin lens 102 can be an ultralens, which collects the scattered light in the sublingual cavity and realizes amplification of the microcirculation light signal. After being amplified by the ultrathin lens 102, the light is transmitted to the signal receiving end 108. The signal receiving end 108 can be an optical fiber coupler, which transmits the light signal out through a flexible optical fiber. The light source 101 is a green micro-ring-shaped light-emitting diode that can emit light with a wavelength of 520-530 nm.

[0083] In order to accurately focus the sublingual blood vessels, a focusing component 107 can be arranged between the ultrathin lens 102 and the signal receiving end 108 to focus the light collected and amplified by the ultrathin lens 102 and accurately transmit the light to the signal receiving end 108.

[0084] In addition, in order to avoid the incident light and reflected light generated by the light beam of the light source on the surface of the sublingual cavity from entering the imaging light path of the detection head body, an optical isolation zone 106 is arranged at the front end of the detection head body. In the optical isolation zone 106, the incident light and reflected light generated on the surface of the sublingual cavity cannot enter. Figure 5 In the optical isolation zone 106, the optical isolation zone 106 looks like a rectangular area, but actually, the optical isolation zone 106 is a section or a ring of isolation zone arranged near the light source in the detection head body according to the shape of the detection head body.

[0085] The light source, the ultralens, and the hook-type structure in the embodiment are the same as those in the above embodiment, and will not be described here.

[0086] Embodiment Two

[0087] The embodiment provides a microcirculation monitoring device for parallel detection, which comprises a sublingual microcirculation detector and an imaging and image processing unit which is arranged separately from the sublingual microcirculation detector. The sublingual microcirculation detector is connected to the imaging and image processing unit through a flexible optical fiber.

[0088] The sublingual microcirculation detector comprises a detection head body, and the detection head body comprises at least a parallel structure detection head. The parallel structure detection head is used to extend towards the tongue bottom of a user so that the surface of the first side of the parallel structure detection head forms a surface contact with the tongue bottom. A containing space is formed in the detection head body, and a light source and an ultrathin lens are arranged in the containing space.

[0089] The light source is used for irradiating a tongue sublingual microcirculation to-be-measured area, and the ultra-thin lens is used for collecting tongue sublingual scattered light, and the light information in the scattered light is converged and coupled into the flexible optical fiber after passing through the imaging channel; the ultra-thin lens is arranged in the accommodation space and located on the second side opposite to the first side, and the ultra-thin lens comprises a plurality of super units arranged on the surface, the plurality of super units are used for receiving scattered light entering the accommodation space through the surface of the parallel structure probe head and containing tongue bottom microcirculation information, and the super units are arranged in different materials and / or shapes according to phase compensation to realize achromatic and / or focusing functions of the scattered light;

[0090] The imaging and image processing unit is in signal connection with the flexible optical fiber, receives the light information transmitted by the flexible optical fiber, amplifies and images the light information;

[0091] When the tongue sublingual microcirculation is monitored, the parallel structure probe head extends towards the tongue bottom of the user to form surface contact with the tongue bottom, the light source emits a probe light beam to the surface of the tongue sublingual tissue, the ultra-thin lens collects the light entering the accommodation space after being scattered and absorbed by the tissue inside, focuses the light into a light beam along the spatial direction of the accommodation space, and continuously transmits the light beam to the imaging and image processing unit through the flexible optical fiber to process tongue sublingual microcirculation image data that can be continuously monitored.

[0092] Compared with the parallel detection hook type microcirculation monitoring device in the first embodiment, the parallel detection microcirculation monitoring device in the embodiment has no limitation on the tongue sublingual microcirculation detection body, which can be hook type or straight. The parallel structure probe head, the light source, the super lens, the optical fiber and the imaging and image processing unit in the embodiment are the same as those described in the first embodiment, and will not be described here.

[0093] Embodiment three

[0094] The embodiment provides an optical fiber type tongue sublingual microcirculation monitoring device, which comprises a tongue sublingual microcirculation detection body and an imaging and image processing unit which is separately arranged with the tongue sublingual microcirculation detection body, and the tongue sublingual microcirculation detection body is connected with the imaging and image processing unit through an optical fiber;

[0095] The tongue sublingual microcirculation detection body further comprises a probe head body, a microcirculation monitoring light source and a reflected light micro lens are arranged at the front end of the probe head body, a flexible optical fiber is arranged in the probe head body, and the reflected light micro lens satisfies the condition that the light spot diameter of the reflected light converging is smaller than the inner diameter of the flexible optical fiber;

[0096] The imaging and image processing unit is in signal connection with the flexible optical fiber, and is used for collecting and processing reflected light spot images absorbed by hemoglobin;

[0097] When the sublingual microcirculation is monitored, the fiber-optic sublingual microcirculation continuous monitoring device projects a light beam onto the surface of the sublingual tissue, collects the light scattered and absorbed by the tissue, focuses the reflected light by a micro-lens into a light beam, and continuously transmits the light beam information to the imaging and image processing unit through the optical fiber, so as to process the sublingual microcirculation image data which can be continuously monitored.

[0098] The fiber-optic sublingual microcirculation monitoring device in the embodiment is different from the first and second embodiments in that the connection mode between the sublingual microcirculation probe and the imaging and image processing unit is limited to be connected by an optical fiber; and the shape and detection mode of the sublingual microcirculation probe are not limited, and the sublingual microcirculation probe can be a hook type or a straight type. The sublingual microcirculation probe can be designed to be parallel to the detection or to be in other detection modes, such as being inclined.

[0099] The embodiments of the present application are described in detail above with reference to the drawings, but the present application is not limited to the above-described embodiments. Even if various changes are made to the present application, as long as the changes fall within the scope of the claims of the present application and equivalent technologies, they still fall within the protection scope of the present application.

Claims

1. A parallel-probing microcirculation monitoring device for tongue base microcirculation monitoring, characterized in that, The device comprises a sublingual microcirculation probe and an imaging and image processing unit which are detachably arranged, wherein the sublingual microcirculation probe and the imaging and image processing unit are connected through a flexible optical fiber; The sublingual microcirculation probe comprises a probe head body which comprises at least a parallel structure probe head, the parallel structure probe head is used to extend towards the tongue bottom of the user, so that the surface of the first side of the parallel structure probe head is in surface contact with the tongue bottom; The imaging and image processing unit is used for receiving the light information transmitted by the flexible optical fiber, amplifying and imaging the light information. A containing space is formed in the probe head body, and a light source and an ultrathin lens are arranged in the containing space. The light source is used for irradiating the to-be-measured area of the sublingual microcirculation. The ultrathin lens is used for collecting scattered light of the to-be-measured area of the sublingual microcirculation and coupling the light information in the scattered light into the flexible optical fiber. The ultrathin lens comprises at least one super unit arranged on a surface, and the at least one super unit is used for receiving the scattered light. Different materials and / or shapes are arranged in the super unit according to phase compensation. An optical isolation area is arranged at the front end of the probe head body. Incident light and reflected light generated on the surface of the tongue cannot enter the optical isolation area. The optical isolation area comprises one section or one ring of isolation area arranged near the light source in the probe head body according to the shape of the probe head body. The ultrathin lens satisfies the phase profile : ， wherein is the designed wavelength, and is the position coordinate of each nano-unit, is the focal length.

2. The apparatus of claim 1, wherein, At least one segment of the probe head body is curved in a hook shape to form a hook structure which can be hung on the teeth of the user.

3. The apparatus of claim 1, wherein, The probe head body is sleeved with a probe sleeve which is in a bionic tongue round arc shape with the contact part of the user's sublingual.

4. The apparatus of claim 3, wherein, The length of the probe sleeve is determined based on different users.

5. The apparatus of claim 4, wherein, A longitudinal opening is arranged in the middle part of the probe sleeve, the probe sleeve is longitudinally sleeved on the probe head body, the probe sleeve is further provided with a clamping structure which is used to fix or separate the probe head body.

6. The apparatus of claim 1, wherein, Two or more light sources are arranged on the side wall of the front end of the probe head body in a transverse or longitudinal manner, the light sources at different positions are controlled to work, and the angle of the light sources with the horizontal direction is adjusted to adapt to different users.

7. The apparatus of claim 6, wherein, The light source is a green light source which is absorbed by red blood cells.

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