A 3D-printed aortic dissection model for assisting detection

Abstract

The application discloses a kind of 3D printing aortic dissection model for auxiliary detection, comprising: liquid peristaltic pump, connecting pipeline, 3D printing aortic dissection model and external fixing frame, the internal lumen of 3D printing aortic dissection model is communicated with liquid peristaltic pump by connecting pipeline, MRI visualization targeted delivery nanoparticle system sample hole is set on 3D printing aortic dissection model, 3D printing aortic dissection model is provided with several 5mm×5mm endovascular intimal tissue fixation points, and MRI visualization targeted delivery nanoparticle system sample hole, endovascular intimal tissue fixation point and 3D printing aortic dissection model are detachably designed.The application can be used for auxiliary detection MRI visualization targeted delivery nanoparticle system 3D printing aortic dissection model, and provides a suitable, efficient and safe in-vitro experimental 3D printing simulation model for MRI detectable targeted delivery nanoparticle system.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of biomedical equipment, in particular to a 3D printing aortic dissection model for auxiliary detection. BACKGROUND

[0002] Acute aortic dissection type A is a clinical emergency, and its early diagnosis and treatment are crucial for the survival and prognosis of patients. MRI is commonly used for imaging diagnosis, but contrast agents are needed to enhance the image. Targeted delivery of nanoparticle systems is a new innovative approach for the diagnosis and treatment of aortic dissection, which needs to be tested in vivo and in vitro before application;

[0003] The existing commonly used experimental model of aortic dissection is an animal model, which is limited by ethical and economic factors. Animal models usually require β-amino propionitrile (BAPN) treatment, which takes 10-14 days, a long period of time. After the establishment of the animal model is successful, ultrasound is needed to determine the success of the model, and then the targeted delivery of nanoparticles is injected into the tail vein, resulting in low efficiency of the detection experiment. In addition, the targeted tissue of the animal model is still single animal origin, which has insufficient applicability.

[0004] Therefore, we propose a 3D printing aortic dissection model for auxiliary detection to solve the problems raised in the background. SUMMARY

[0005] The present application aims to provide a 3D printing aortic dissection model for auxiliary detection to solve the problems raised in the background.

[0006] To achieve the above-mentioned purpose, the present application provides the following technical scheme: a 3D printing aortic dissection model for auxiliary detection, comprising: a liquid peristaltic pump, a connecting pipeline, a 3D printing aortic dissection model and an external fixing frame.

[0007] The internal lumen of the 3D printing aortic dissection model is in communication with the liquid peristaltic pump through the connecting pipeline;

[0008] An MRI imaging targeted delivery of nanoparticle system sample hole is arranged on the 3D printing aortic dissection model;

[0009] A plurality of 5mm x 5mm endovascular tissue fixation points are arranged on the 3D printing aortic dissection model;

[0010] The MRI imaging targeted delivery of nanoparticle system sample hole, the endovascular tissue fixation points and the 3D printing aortic dissection model are designed to be detachable.

[0011] Preferably, both ends of the connecting pipeline are provided with a connecting assembly, the liquid peristaltic pump, the connecting pipeline and the inner cavity of the 3D-printed aortic dissection model form an internal flowable circulating liquid closed tube cavity.

[0012] Preferably, the 3D-printed aortic dissection model is fixed on an external fixing frame and kept in an upright state to simulate a physiological body position.

[0013] Preferably, the internal circulating liquid of the liquid peristaltic pump, the connecting pipeline and the 3D-printed aortic dissection model is 37℃ physiological saline to simulate the internal environment of the human body and blood flow dynamics.

[0014] Preferably, the MRI imaging targeted delivery nanoparticle system sample adding hole, the vascular endothelial tissue fixing point and the 3D-printed aortic dissection model are 3D-printed by using a special resin material.

[0015] Compared with the prior art, the 3D-printed aortic dissection model has the following beneficial effects:

[0016] The 3D-printed aortic dissection model can be used for assisting in detecting the MRI imaging targeted delivery nanoparticle system. After the model is established, the internal fluid simulation can be established by an external peristaltic pump. The model is provided with a vascular endothelial adhesion point and a drug adding hole, and can quickly and repeatedly perform multiple experiments without modeling waiting time. In addition, multiple source tissues can be replaced as experimental materials, so that the MRI detectable targeted delivery nanoparticle system is provided with a suitable, efficient and safe in-vitro experimental 3D-printed simulation model. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 The figure is a structural schematic diagram of the present application;

[0018] Figure 2 The figure is an enlarged view of A of the present application; Figure 1

[0019] Figure 3 The figure is a structural schematic diagram of the external fixing frame and the 3D-printed aortic dissection model in the present application.

[0020] In the figure: 1, liquid peristaltic pump; 2, connecting pipeline; 3, MRI imaging targeted delivery nanoparticle system sample adding hole; 4, vascular endothelial tissue fixing point; 5, 3D-printed aortic dissection model; 6, external fixing frame; 7, connecting assembly. DETAILED DESCRIPTION

[0021] ​The technical solutions in the embodiments of the present application will be clearly and completely described with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0022] Please refer to Figures 1-3 The present application provides a technical solution: an auxiliary detection 3D-printed aortic dissection model, comprising: a liquid peristaltic pump 1, a connecting pipeline 2, a 3D-printed aortic dissection model 5 and an external fixing frame 6.

[0023] The internal lumen of the 3D-printed aortic dissection model 5 is in communication with the liquid peristaltic pump 1 through the connecting pipeline 2.

[0024] Both ends of the connecting pipeline 2 are provided with connecting assemblies 7, which make the connecting pipeline 2 communicate the 3D-printed aortic dissection model 5 and the liquid peristaltic pump 1, forming an internal flowable circulating liquid sealed lumen.

[0025] The 3D-printed aortic dissection model 5 is fixed on the external fixing frame 6 and kept in an upright state to simulate a physiological body position.

[0026] After the liquid peristaltic pump 1 is started, the connecting pipeline 2 and the 3D-printed aortic dissection model 5 form a closed loop system, and the internal liquid is selected as 37℃ physiological saline to simulate the human body environment and blood flow dynamics.

[0027] The 3D-printed aortic dissection model 5 is provided with an MRI imaging targeted delivery nanoparticle system sample adding hole 3, which can add MRI imaging targeted delivery nanoparticles. Meanwhile, the 3D-printed aortic dissection model 5 is provided with 5mm*5mm endovascular tissue fixation points 4 at different positions, which can fix different tissue source aortic endovascular models according to the experimental design needs. With the internal liquid flowing, the targeted delivery nanoparticles are combined with the aortic intimal tissue.

[0028] The MRI imaging targeted delivery nanoparticle system sample adding hole 3, the endovascular tissue fixation point 4 and the 3D-printed aortic dissection model 5 are designed to be detachable. The MRI imaging targeted delivery nanoparticle system sample adding hole 3, the endovascular tissue fixation point 4 and the 3D-printed aortic dissection model 5 are formed by 3D printing with special resin materials, which can be used for MRI detection. After the experiment is completed, MRI imaging and subsequent detection experiments can be performed.

[0029] Working principle: the 3D printing aortic dissection model 5 is a carrier, and the aortic dissection model can be established according to different experimental designs and individualized clinical imaging data, more similar to simulate the corresponding aortic structure and hemodynamic parameters, and the device can be disassembled MRI imaging targeted delivery nanoparticle system adding hole 3 and vascular endometrial tissue fixation point 4, the material characteristics of which can be used for MRI detection, which can meet the imaging detection requirements, the whole device has the advantages of individualized model, repeatable detection, and higher MRI detection efficiency.

[0030] The contents not described in detail in the specification belong to the prior art known to those skilled in the art.

[0031] Although the embodiments of the present application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present application, and the scope of the present application is defined by the appended claims and their equivalents.

Claims

1. An assisted detection 3D-printed model of aortic dissection, characterized in that: The utility model relates to a kind of 3D printing aortic dissection model, including: Liquid peristaltic pump (1), connecting pipeline (2), 3D printing aortic dissection model (5) and external fixing frame (6); The internal lumen of the 3D printing aortic dissection model (5) is in communication with the liquid peristaltic pump (1) through the connecting pipeline (2); The 3D printing aortic dissection model (5) is provided with an MRI imaging targeted delivery nanoparticle system sample adding hole (3); The 3D printing aortic dissection model (5) is provided with a plurality of 5mm×5mm endovascular intimal tissue fixation points (4); The MRI imaging targeted delivery nanoparticle system sample adding hole (3), the endovascular intimal tissue fixation point (4) and the 3D printing aortic dissection model (5) are designed to be detachable; The 3D printing aortic dissection model (5) is fixed on the external fixing frame (6) and kept in an upright state to simulate a physiological position; The liquid circulating in the liquid peristaltic pump (1), the connecting pipeline (2) and the 3D printing aortic dissection model (5) is selected to be 37℃ physiological saline to simulate the human body environment and hemodynamics.

2. The 3D-printed aortic dissection model for assisting detection according to claim 1, wherein, Both ends of the connecting pipeline (2) are provided with connecting assemblies (7), and the inner cavities of the liquid peristaltic pump (1), the connecting pipeline (2) and the 3D printing aortic dissection model (5) form an internal flowable circulating liquid closed cavity.

3. The 3D-printed aortic dissection model for assisting detection according to claim 1, wherein, The MRI imaging targeted delivery nanoparticle system sample adding hole (3), the endovascular intimal tissue fixation point (4) and the 3D printing aortic dissection model (5) are formed by 3D printing with special resin materials.

4. A 3D-printed aortic dissection model for assisting detection based on the model of claim 1, characterized in that, The working principle of the 3D printing aortic dissection model is that, after the liquid peristaltic pump (1) is started, the connecting pipeline (2) and the 3D printing aortic dissection model (5) form a closed loop system, and the internal liquid is selected to be 37℃ physiological saline to simulate the human body environment and hemodynamics. The 3D printing aortic dissection model (5) is provided with the MRI imaging targeted delivery nanoparticle system sample adding hole (3), which can be filled with MRI imaging targeted delivery nanoparticles. The MRI imaging targeted delivery nanoparticle system sample adding hole (3), the endovascular intimal tissue fixation point (4) and the 3D printing aortic dissection model (5) are designed to be detachable, and are formed by 3D printing with special resin materials. The MRI imaging targeted delivery nanoparticle system sample adding hole (3), the endovascular intimal tissue fixation point (4) and the 3D printing aortic dissection model (5) can be used for MRI detection, and after the experiment is completed, MRI imaging and subsequent detection experiments can be carried out.

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