An anti-aging emulsion and a method for preparing the same

Abstract

The application discloses an anti-aging emulsion and a preparation method thereof, and relates to the field of skin care products. The anti-aging emulsion comprises an A phase, a B phase and a C phase. The A phase comprises caprylic triglyceride, shea butter, squalane, organosiloxane, cetyl stearyl alcohol, hydroxyl pinacolone sulfonate, an emulsifier and an antioxidant. The B phase comprises a humectant A, wild soybean seed extract, p-hydroxyacetophenone, a thickening agent and water. The C phase comprises a humectant B, burl walnut seed oil, purslane extract, blackberry leaf extract, a skin conditioner, dipeptide diaminobutyl benzyl amide diacetate, palmitoyl tripeptide-5, spilanthes extract and a pH regulator. The emulsion has the advantages of high anti-aging efficiency, can quickly improve the wrinkle condition of the face, and has no stimulation to the skin, so that the skin does not have the problems of red spots or local itching.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to an anti-aging lotion and its preparation method. Background Technology

[0002] As the global population continues to age, "healthy aging" has gradually developed into a new consumer market, leading to an increasing demand for anti-aging skincare products.

[0003] Vitamin A has reliable efficacy and evidence in anti-aging, and it is often overlooked when preparing anti-aging skincare products. Retinoids, which are structurally and functionally similar to retinol (i.e., vitamin A), are also commonly used in anti-aging skincare products.

[0004] Trans-retinoic acid is a retinol-like substance with high anti-aging efficacy, but it also has the disadvantage of being highly irritating and unsuitable for pregnant women. Hydroxypinazone retinate is a novel retinol-like substance with low cytotoxicity and minimal irritation. However, at the same concentration, hydroxypinazone retinate has a weaker effect at the transcriptional level than trans-retinoic acid, resulting in a slower anti-aging efficiency. Therefore, developing anti-aging skincare products with excellent efficacy and minimal irritation using hydroxypinazone retinate is of significant research importance. Summary of the Invention

[0005] In order to improve the anti-aging efficiency of skin care products while reducing their irritation, this application provides an anti-aging lotion and its preparation method.

[0006] Firstly, the anti-aging lotion provided in this application adopts the following technical solution:

[0007] An anti-aging emulsion comprising phase A, phase B, and phase C; phase A comprising 3-10 parts by weight of caprylic / capric triglycerides, 3-10 parts by weight of shea butter, 1-5 parts by weight of squalane, 2-10 parts by weight of organosiloxane, 0.1-1 parts by weight of cetearyl alcohol, 0.1-2 parts by weight of hydroxypinazone retinyl sulfonate, 1-5 parts by weight of emulsifier, and 0.1-0.5 parts by weight of antioxidant;

[0008] Phase B comprises 8-28 parts by weight of humectant A, 0.1-1 parts by weight of wild soybean seed extract, 0.1-0.8 parts by weight of p-hydroxyacetophenone, 0.2-1 parts by weight of thickener, and 50-80 parts by weight of water;

[0009] Phase C comprises 0.21-1.9 parts by weight of moisturizer B, 0.01-0.5 parts by weight of burdock seed oil, 1-3 parts by weight of purslane extract, 0.01-0.5 parts by weight of blackberry leaf extract, 0.11-1.2 parts by weight of skin conditioning agent, 1-5 parts by weight of dipeptide diaminobutyryl benzylamide diacetate, 1-5 parts by weight of palmitoyl tripeptide-5, 1-5 parts by weight of chamomile extract, and 0.1-0.5 parts by weight of pH adjuster.

[0010] The anti-aging emulsion made from phases A, B, and C in this application has a microcapsule-like sustained-release structure similar to water / oil / water, which can slowly release moisturizing ingredients, thereby continuously hydrating the skin over a longer period of time. It does not release moisturizing ingredients instantly, thus avoiding waste, and it does not overload the skin instantly, thus avoiding allergies or irritation. It has the advantages of being gentle and non-irritating.

[0011] Secondly, the anti-aging emulsion of this application not only contains wild soybean seed extract, burdock seed oil, purslane extract and blackberry leaf extract, which have anti-aging effects, but also contains hydroxypinazone retinyl ester, dipeptide diaminobutyryl benzylamide diacetate, palmitoyl tripeptide-5 and chamomile extract, which can synergistically and effectively improve the anti-aging efficiency of the emulsion.

[0012] At the same concentration, hydroxypinazone retinyl ester has a weaker effect on gene transcription than trans-retinoic acid, but a stronger effect than retinaldehyde and retinyl palmitate, and can promote procollagen synthesis. However, at the highest dose, hydroxypinazone retinyl ester has a higher transcriptional level than trans-retinoic acid, and does not induce stronger inflammation than trans-retinoic acid. However, considering its irritant properties, the dose of hydroxypinazone retinyl ester is usually not increased to the maximum.

[0013] Dipeptide diaminobutyryl benzylamide diacetate is a synthetic peptide that mimics snake venom serum. It can prevent acetylcholine from binding to muscle cells, thereby relaxing muscles and improving dynamic wrinkles.

[0014] Palmitoyl tripeptide-5 can promote skin cell growth, inhibit oxygen free radicals and hydroxyl free radicals, and promote the synthesis of matrix proteins, especially collagen. It may also increase the production of elastin, hyaluronic acid, glycosaminoglycans and fibronectin, effectively smoothing fine lines and increasing skin elasticity.

[0015] This application combines dipeptide diaminobutyryl benzylamide diacetate and palmitoyl tripeptide-5 with hydroxypinazone retinyl sulfonate, which can fundamentally improve skin aging problems.

[0016] Furthermore, to enhance anti-aging efficiency and achieve noticeable anti-aging effects after short-term use of the emulsion, this application also includes chamomile extract. Chamomile extract itself has the ability to eliminate free radicals, thus alleviating aging. Moreover, chamomile extract may also contain substances that promote the activity of hydroxypinazone retinyl ester, dipeptide diaminobutyryl benzylamide diacetate, and palmitoyl tripeptide-5, thereby achieving rapid anti-aging.

[0017] Optionally, the hydroxypinazone retinyl ester is 1.5-2 parts by weight, the dipeptide diaminobutyryl benzylamide diacetate is 1-2 parts by weight, the palmitoyl tripeptide-5 is 2.5-3 parts by weight, and the chrysanthemum extract is 1-2 parts by weight.

[0018] When the ratio of hydroxypinazone retinyl ester, dipeptide diaminobutyryl benzylamide diacetate, palmitoyl tripeptide-5, and chamomile extract is within the above range, the emulsion can produce a significant anti-aging effect in a short period of time, that is, the anti-aging efficiency of the emulsion is further improved.

[0019] Optionally, the hydroxypinazone retinyl ester is 1.5 parts by weight, the dipeptide diaminobutyryl benzylamide diacetate is 2 parts by weight, the palmitoyl tripeptide-5 is 2.5 parts by weight, and the chrysanthemum extract is 1 part by weight.

[0020] When the ratio of hydroxypinazone retinyl ester, dipeptide diaminobutyryl benzylamide diacetate, palmitoyl tripeptide-5, and chamomile extract is within the above range, the emulsion has the fastest anti-aging efficiency.

[0021] Optionally, the moisturizer A comprises 3-10 parts by weight of butylene glycol, 3-10 parts by weight of nicotinamide, 1-5 parts by weight of glycerin, and 1-3 parts by weight of glyceryl polyacrylate.

[0022] The combination of butylene glycol, niacinamide, glycerin, and glyceryl polyacrylate can enhance the moisturizing and water-locking effect of lotion, and improve skin problems such as wrinkles, peeling, and enlarged pores caused by aging or external damage.

[0023] Optionally, the moisturizer B includes 0.1-1 parts by weight of PatcH2O, 0.01-0.1 parts by weight of sodium hyaluronate, and 0.1-0.8 parts by weight of 1,2-hexanediol.

[0024] Optionally, the emulsifier includes isostearyl alcohol, butylene glycol cocoate, and ethyl cellulose, wherein the weight ratio of isostearyl alcohol, butylene glycol cocoate, and ethyl cellulose is 10:(5-10):(0.1-0.2).

[0025] When the weight ratio of isostearyl alcohol, butylene glycol cocoate, and ethyl cellulose is within the above range, the stability of the emulsion can be further improved, which is conducive to the emulsion fully exerting its anti-aging effect.

[0026] Optionally, the extraction method of the chrysanthemum extract includes the following steps:

[0027] Take dried chrysanthemum, crush it, add acetic acid solution, and then ultrasonically soak it at 45-55℃ for 3-4 hours. Filter it to obtain extract A and filter residue A. The weight ratio of acetic acid solution to dry weight of chrysanthemum is (10-15):1.

[0028] After drying the filter residue A at 50-60℃, add ethanol solution, ultrasonically soak at 45-55℃ for 3-4 hours, filter, and obtain extract B and filter residue B; the weight ratio of ethanol solution to dried filter residue A is (8-10):1.

[0029] After uniformly mixing extract A and extract B at a weight ratio of (2-3):1, vacuum distillation was carried out to obtain chrysanthemum extract; wherein the vacuum distillation temperature was controlled at 60-70℃ and the pressure was controlled at 1-2kPa.

[0030] The chrysanthemum extract prepared by the above method can not only effectively improve the anti-aging efficiency of the emulsion, but also improve the anti-aging stability of the emulsion.

[0031] Optionally, the drying method of the chrysanthemum is vacuum freeze-drying, with a freeze-drying temperature of <-40℃ and a vacuum degree of 10-30Pa.

[0032] The Thousand-Day Chrysanthemum is dried using a vacuum freeze-drying method, which can retain the effective substances to the greatest extent and reduce the possibility of the effective substances volatilizing due to high temperature.

[0033] Optionally, the length of the broken chrysanthemum is 2-3 mm.

[0034] The length of the broken pieces of chrysanthemum should be controlled at 2-3mm. This facilitates filtration and accelerates the leaching of effective substances.

[0035] Secondly, the preparation method of the anti-aging emulsion provided in this application adopts the following technical solution:

[0036] A method for preparing an anti-aging lotion includes the following steps:

[0037] According to the formula, put the A phase raw material into the oil pot and heat it to 85℃ to disperse it completely;

[0038] According to the formula, add the B phase raw material into a water bath and heat it to 80-85℃ to dissolve it;

[0039] Mix the substances in the oil pot and water pot, stir evenly, homogenize at 80-85℃, then degas and cool simultaneously, reducing the temperature to about 48℃ to obtain the premix.

[0040] Add the C-phase raw materials to the premix according to the formula, stir evenly, and you will get an anti-aging emulsion.

[0041] In summary, the technical solution claimed in this application has at least the following beneficial effects:

[0042] 1. The lotion of this application has the advantage of high anti-aging efficiency, which can quickly improve the condition of facial wrinkles, while being non-irritating to the skin and not causing red spots or local itching.

[0043] 2. When the emulsion of this application is prepared using chrysanthemum extract obtained by a specific method, the anti-aging stability of the emulsion is improved, and long-lasting anti-aging can be achieved. Detailed Implementation

[0044] The present application will be further described in detail below with reference to specific embodiments and comparative examples.

[0045] Example

[0046] Examples 1-3

[0047] The composition of an anti-aging lotion is shown in Table 1 below.

[0048] Table 1. Components and proportions of the anti-aging emulsions in Examples 1-3 (unit / kg)

[0049]

[0050]

[0051] The emulsifier consists of 50g isostearyl alcohol, 100g butylene glycol cocoate and 0.5g ethyl cellulose; the anti-aging component consists of 0.15kg bitter orange blossom oil, 1.5kg lavender oil, 1kg geranium oil and 0.3kg frankincense oil.

[0052] In addition, the preparation method of the anti-aging emulsion in Examples 1-3 includes the following steps:

[0053] According to the formula, put the A phase raw material into the oil pot and heat it to 85℃ to disperse it completely;

[0054] According to the formula, add the B phase raw material into a water bath and heat it to 80-85℃ to dissolve it;

[0055] Mix the substances in the oil pot and water pot, stir evenly, homogenize at 80-85℃ for 2 hours, then degas and cool simultaneously to about 48℃ to obtain the premix.

[0056] Add the C-phase raw materials to the premix according to the formula, stir evenly, and you will get an anti-aging emulsion.

[0057] Example 4

[0058] An anti-aging lotion, differing from Example 2 in that:

[0059] Hydroxypinazone resorcinate 1.5 kg, dipeptide diaminobutyryl benzylamide diacetate 1.0 kg, palmitoyl tripeptide-5 2.0 kg, and ACMELLA OLERACEA extract 2.5 kg.

[0060] Example 5

[0061] An anti-aging lotion, differing from Example 2 in that:

[0062] Hydroxypinazone resorcinate was 1.5 kg, dipeptide diaminobutyryl benzylamide diacetate was 2.0 kg, palmitoyl tripeptide-5 was 2.5 kg, and ACMELLA OLERACEA extract was 1.0 kg.

[0063] Example 6

[0064] An anti-aging lotion, differing from Example 5 in that:

[0065] The emulsifier consists of 100g isostearyl alcohol, 50g butylene glycol cocoate and 1g ethyl cellulose.

[0066] Example 7

[0067] An anti-aging lotion, differing from Example 5 in that:

[0068] The emulsifier consists of 100g isostearyl alcohol, 100g butylene glycol cocoate and 5g ethyl cellulose.

[0069] Example 8

[0070] An anti-aging lotion, differing from Example 6 in that:

[0071] The preparation method of ACMELLA OLERACEA extract includes the following steps:

[0072] The freeze-dried chrysanthemum was crushed to a length of 2-3 mm, acetic acid solution was added, and then ultrasonically soaked at 50℃ for 3.5 h. After filtration, extract A and filter residue A were obtained. The freeze-drying temperature of the chrysanthemum was -50℃, and the weight ratio of acetic acid solution to the dry weight of the chrysanthemum was 12:1.

[0073] After drying the filter residue A at 55℃, add ethanol solution, ultrasonically soak at 50℃ for 3.5h, filter, and obtain extract B and filter residue B; the weight ratio of ethanol solution to dried filter residue A is 9:1.

[0074] After uniformly mixing extract A and extract B at a weight ratio of 2.5:1, the vacuum distillation temperature was controlled at 70℃ and the pressure was controlled at 2KPa. The distillation was carried out until the volume of the concentrated liquid was reduced to half, thus obtaining the chrysanthemum extract.

[0075] Example 9

[0076] An anti-aging lotion, differing from Example 8 in that:

[0077] The preparation method of ACMELLA OLERACEA extract includes the following steps:

[0078] The freeze-dried chrysanthemum was crushed to a length of 2-3 mm, added to an ethanol solution, and ultrasonically soaked at 50°C for 3.5 h. After filtration, the extract and filter residue were obtained. The freeze-drying temperature of the chrysanthemum was -50°C, and the weight ratio of the ethanol solution to the dry weight of the chrysanthemum was 9:1.

[0079] The extract was subjected to vacuum distillation at a temperature of 70°C and a pressure of 2 kPa until the volume of the concentrate was reduced to half, thus obtaining the chrysanthemum extract.

[0080] Example 10

[0081] An anti-aging lotion, differing from Example 8 in that:

[0082] The preparation method of ACMELLA OLERACEA extract includes the following steps:

[0083] The freeze-dried chrysanthemum was crushed to a length of 2-3 mm, acetic acid solution was added, and then ultrasonically soaked at 50℃ for 3.5 h. After filtration, the extract and filter residue were obtained. The freeze-drying temperature of the chrysanthemum was -50℃, and the weight ratio of acetic acid solution to the dry weight of the chrysanthemum was 12:1. The extract was subjected to vacuum distillation at a temperature of 70℃ and a pressure of 2 kPa until the volume of the concentrated liquid was reduced to half, thus obtaining the chrysanthemum extract.

[0084] Example 11

[0085] An anti-aging lotion, differing from Example 8 in that:

[0086] The preparation method of ACMELLA OLERACEA extract includes the following steps:

[0087] The Globe Amaranth is dried at a high temperature of 100℃.

[0088] Comparative Example

[0089] Comparative Example 1

[0090] An anti-aging lotion, which differs from Example 2 in that:

[0091] Hydroxypinazone resorcinate was replaced with an equal amount of palmitoyl tripeptide-5.

[0092] Comparative Example 2

[0093] An anti-aging lotion, which differs from Example 2 in that:

[0094] Dipeptide diaminobutyryl benzylamide diacetate was replaced with an equal amount of hydroxypinazone retinyl sulfonate.

[0095] Comparative Example 3

[0096] An anti-aging lotion, which differs from Example 2 in that:

[0097] Palmitoyl tripeptide-5 was replaced with an equal amount of hydroxypinazone resinate.

[0098] Comparative Example 4

[0099] An anti-aging lotion, which differs from Example 2 in that:

[0100] The chrysanthemum extract was replaced with an equal amount of blackberry leaf extract.

[0101] Performance test

[0102] 1. Stability: After placing the product to be tested in a 60℃ electric thermostatic incubator for 90 days, it was restored to room temperature. The product was then observed for any signs of oil seepage, water separation, or demulsification.

[0103] 2. Anti-aging effect test

[0104] One hundred and fifty healthy volunteers aged 50-60 years with similar wrinkles around their eyes and dry skin were selected and divided into 15 groups. They used the lotions corresponding to the examples and the comparison examples every morning and evening, and the average usage time when the wrinkles around the eyes were significantly improved (the number of wrinkles was halved) was recorded.

[0105] Table 2. Emulsion stability and anti-aging efficiency of each example and comparative example.

[0106]

[0107] Based on the data from Examples 2 and Comparative Examples 1-4, and in conjunction with Table 2, it can be seen that hydroxypinazone retinyl ester, dipeptide diaminobutyryl benzylamide diacetate, palmitoyl tripeptide-5, and chamomile extract can synergistically improve the anti-aging efficiency of the emulsion and shorten the time it takes for the emulsion to improve wrinkles.

[0108] Based on Examples 5-7 and the data in Table 2, it can be seen that when the weight ratio of isostearyl alcohol, butylene glycol cocoate, and ethyl cellulose is in the range of 10:(5-10):(0.1-0.2), the stability of the emulsion can be further improved, which is conducive to the emulsion fully exerting its anti-aging effect.

[0109] Based on Examples 6 and 8-11 and the data in Table 2, it can be seen that the chrysanthemum extract prepared according to the preparation method claimed in this application can not only further improve the anti-aging efficiency of the emulsion, but also improve the anti-aging stability of the emulsion, so that the emulsion has good anti-aging effects in both the short and long term.

Claims

1. An anti-aging emulsion characterized in that: The A phase includes 3-10 parts by weight of caprylic acid / capric acid triglyceride, 3-10 parts by weight of shea butter, 1-5 parts by weight of squalane, 2-10 parts by weight of organosiloxane, 0.1-1 part by weight of cetyl stearyl alcohol, 1.5-2 parts by weight of hydroxyl pinacolone sulfonate, 1-5 parts by weight of emulsifier, and 0.1-0.5 parts by weight of antioxidant; the B phase includes 8-28 parts by weight of moisturizing agent A, 0.1-1 part by weight of wild soybean seed extract, 0.1-0.8 part by weight of p-hydroxyacetophenone, 0.2-1 part by weight of thickening agent, and 50-80 parts by weight of water; the C phase includes 0.21-1.9 parts by weight of moisturizing agent B, 0.01-0.5 parts by weight of burr walnut seed oil, 1-3 parts by weight of purslane extract, 0.01-0.5 parts by weight of blackberry leaf extract, 0.11-1.2 parts by weight of skin conditioner, 1-2 parts by weight of dipeptide diaminobutyryl benzyl amide diacetate, 2.5-3 parts by weight of palmitoyl tripeptide-5, 1-2 parts by weight of spilanthes extract, and 0.1-0.5 parts by weight of pH adjuster; The extraction method of the spilanthes extract includes the following steps: taking dried spilanthes, crushing, adding acetic acid solution, then ultrasonic soaking at 45-55℃ for 3-4h, filtering to obtain extract A and residue A; the weight ratio of acetic acid solution to dry spilanthes is (10-15):1; after drying the residue A at 50-60℃, adding ethanol solution, ultrasonic soaking at 45-55℃ for 3-4h, filtering to obtain extract B and residue B; the weight ratio of ethanol solution to dried residue A is (8-10):1; uniformly mixing extract A and extract B according to the weight ratio (2-3):1, then reducing pressure distillation to obtain spilanthes extract; wherein the reducing pressure distillation temperature is controlled at 60-70℃, and the pressure is controlled at 1-2kPa.

2. The anti-aging emulsion of claim 1, wherein: The hydroxyl pinacolone sulfonate is 1.5 parts by weight, the dipeptide diaminobutyryl benzyl amide diacetate is 2 parts by weight, the palmitoyl tripeptide-5 is 2.5 parts by weight, and the spilanthes extract is 1 part by weight.

3. The anti-aging emulsion of claim 1, wherein: The moisturizing agent A includes 3-10 parts by weight of butanediol, 3-10 parts by weight of nicotinamide, 1-5 parts by weight of glycerol, and 1-3 parts by weight of glycerol polyacrylate.

4. The anti-aging emulsion of claim 1, wherein: The moisturizing agent B includes 0.1-1 part by weight of PatcH2O, 0.01-0.1 part by weight of sodium hyaluronate, and 0.1-0.8 part by weight of 1,2-hexanediol.

5. The anti-aging emulsion of claim 1, wherein: The emulsifier includes isostearyl alcohol, butanediol cocoate, and ethyl cellulose, and the weight ratio of isostearyl alcohol, butanediol cocoate, and ethyl cellulose is 10:(5-10):(0.1-0.2).

6. The anti-aging emulsion of claim 1, wherein: The drying method of the spilanthes is vacuum freeze-drying, and the freeze-drying temperature is <-40℃.

7. The anti-aging emulsion of claim 1, wherein: The length of the crushed spilanthes is 2-3mm.

8. A method for preparing an anti-aging emulsion according to any one of claims 1 to 7, characterized in that, The method includes the following steps: The A phase raw materials are put into an oil pot according to the proportion, and heated to 85 DEG C until completely dispersed; the B phase raw materials are put into a water pot according to the proportion, and heated to 80-85 DEG C until dissolved; the substances in the oil pot and the water pot are mixed, stirred uniformly, homogenized at 80-85 DEG C, then degassed and cooled, and cooled to about 48 DEG C, to obtain a premix; the C phase raw materials are added to the premix according to the proportion, stirred uniformly, to obtain an anti-aging emulsion.

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