Preparation method of compositae composition and application of compositae composition in tightening, wrinkle resisting and barrier repairing

Abstract

The invention discloses a preparation method of a compositae composition and application of the compositae composition in tightening, wrinkle resisting and barrier repairing. The compositae composition comprises the following components in percentage by mass: 1-5% of a chrysanthemum extract, 1-5% of a purple coneflower extract, less than or equal to 2% of an auxiliary compositae extract, 5-20% of water, 2-8% of a cosolvent and the balance of dipropylene glycol. The cosolvent is prepared from at least one of polysorbate-20 and PEG-40 (Polyethylene Glycol 40) hydrogenated castor oil; the auxiliary compositae extract comprises one or more of a daisy extract, a chamomile extract, a calendula officinalis extract, a sunflower extract, a bighead atractylodes rhizome extract and a rhizoma atractylodis extract.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic raw material technology, specifically relating to a method for preparing a chrysanthemum family composition and its application in firming, anti-wrinkle, and barrier repair. Background Technology

[0002] With the upgrading of skincare needs, consumers have placed higher demands on the efficacy and safety of cosmetics, making products that combine firming and anti-wrinkle effects with skin barrier repair a market hotspot. Plant extracts are widely used in the cosmetics industry due to their high safety and rich active ingredients. Among them, extracts from Asteraceae plants contain alkylamides, polysaccharides, flavonoids, and other components that have potential effects such as anti-oxidation, anti-inflammation, and promoting collagen synthesis.

[0003] However, in existing technologies, single Asteraceae plant extracts have problems such as limited efficacy and low transdermal absorption rate of active ingredients, making it difficult to simultaneously meet the needs of firming and anti-wrinkle and barrier repair. When multiple ingredients are combined, the active ingredients often interfere with each other and have poor synergistic effects due to unreasonable selection of plant species, unbalanced ratios, and crude preparation processes. In addition, some compound products have insufficient safety and cannot be suitable for special skin types such as sensitive skin and early signs of aging.

[0004] Therefore, there is an urgent need to develop a compound composition that can fully leverage the synergistic effects of each component by rationally selecting Asteraceae plant species and compounding ratios and optimizing the preparation process, thereby achieving both highly effective firming and anti-wrinkle effects, barrier repair functions, and high safety, in order to overcome the shortcomings of existing technologies. Summary of the Invention

[0005] The purpose of this invention is to provide a chrysanthemum family composition with firming, anti-wrinkle, and barrier repair effects, a method for preparing the same, and the application of the composition in firming, anti-wrinkle, and barrier repair.

[0006] A chrysanthemum composition comprising the following components in weight percentages: 1-5% *Chrysanthemum indicum* extract, 1-5% *Echinacea purpurea* extract, ≤2% auxiliary chrysanthemum extract, 5-20% water, 2-8% cosolvent, and the balance being dipropylene glycol; wherein the cosolvent comprises at least one of polysorbate-20 and PEG-40 hydrogenated castor oil; and wherein the auxiliary chrysanthemum extract comprises one or more of daisy extract, chamomile extract, calendula extract, sunflower extract, atractylodes macrocephala extract, and atractylodes lancea extract.

[0007] A method for preparing the above-mentioned Asteraceae composition includes the following steps: (1) Weigh dipropylene glycol, co-solvent and water, and stir for 10-20 min at 25-35℃ and 300-500 r / min to obtain the basic carrier solution; (2) Add chrysanthemum extract, purple coneflower extract and auxiliary chrysanthemum extract to the base carrier solution, and stir at 25-35℃ and 300-500r / min for 20-30min; (3) Sterilize by filtration using a 0.22μm microporous membrane, and dispense under aseptic conditions to obtain the product.

[0008] Beneficial effects (1) This invention achieves synergistic effects of firming and anti-wrinkle and barrier repair ingredients by precisely controlling the proportion of each Asteraceae extract. At the same time, the excipient ratio is reasonable, ensuring the stability of the system and avoiding degradation of active ingredients.

[0009] (2) The preparation method of the Asteraceae composition of the present invention has precise and controllable process parameters, is simple to operate, can effectively avoid the inactivation of active ingredients during the preparation process, and at the same time ensures the sterility of the product and improves the safety of use. Detailed Implementation

[0010] One embodiment of the present invention provides a chrysanthemum-based composition comprising the following components in the indicated mass percentages: 1-5% *Chrysanthemum indicum* extract, 1-5% *Echinacea purpurea* extract, ≤2% auxiliary chrysanthemum extracts, 5-20% water, 2-8% cosolvent, and the balance being dipropylene glycol; the cosolvent includes at least one of polysorbate-20 and PEG-40 hydrogenated castor oil; the auxiliary chrysanthemum extracts include one or more of daisy extract, chamomile extract, calendula extract, sunflower extract, *Atractylodes macrocephala* extract, and *Atractylodes lancea* extract. In the above-mentioned chrysanthemum-based composition, by precisely controlling the proportions of each chrysanthemum extract, a synergistic effect of firming and anti-wrinkle and barrier repair components is achieved. Simultaneously, the reasonable ratio of excipients ensures system stability and avoids degradation of active ingredients.

[0011] Another embodiment of the present invention provides a method for preparing the above-mentioned Asteraceae composition, comprising the following steps: (1) Weigh dipropylene glycol, co-solvent and water, and stir for 10-20 min at 25-35℃ and 300-500r / min to obtain the basic carrier solution.

[0012] (2) Add chrysanthemum extract, purple coneflower extract and auxiliary chrysanthemum extract to the base carrier liquid, and stir at 25-35℃ and 300-500r / min for 20-30min.

[0013] (3) Sterilize by filtration using a 0.22μm microporous membrane, and dispense under aseptic conditions to obtain the product.

[0014] The preparation method of the above-mentioned Asteraceae composition has precise and controllable process parameters, is simple to operate, can effectively avoid the inactivation of active ingredients during the preparation process, and at the same time ensures the sterility of the product and improves the safety of use.

[0015] In some embodiments, the extraction method for extracts from various Asteraceae plants includes steps such as raw material pretreatment, nanoscale extraction, filtration purification, concentration and drying, and microencapsulation. This extraction method ensures the purity and activity stability of the extracts, while microencapsulation technology enables intelligent sustained release of active ingredients, prolonging the duration of efficacy.

[0016] In some embodiments, the raw material pretreatment includes: selecting medicinal parts of plants in the Asteraceae family, washing and drying them, and then pulverizing them to 20-40 mesh to obtain raw material powder; wherein, the medicinal parts of plants in the Asteraceae family include: flowers of Globe amaranth, roots and flowers of Echinacea purpurea, flowers of daisy, flowers of chamomile, flowers of calendula, seeds of sunflower, rhizomes of Atractylodes macrocephala, and rhizomes of Atractylodes lancea.

[0017] In some embodiments, nanoscale extraction uses a 50-70% ethanol aqueous solution as the extraction solvent, with a raw material powder to solvent mass-volume ratio of 1:10-1:20, an extraction temperature of 35-45℃, and a pressure of 0.3-0.5MPa.

[0018] In some embodiments, filtration purification includes: after extraction, filtering through a 200-mesh filter to remove residue, and then filtering the filtrate through a 0.45μm microporous membrane to obtain purified filtrate.

[0019] In some embodiments, the concentration and drying process includes: concentrating the purified filtrate under reduced pressure at a vacuum of -0.08 to -0.09 MPa and a temperature of 40-50°C to obtain an extract with a relative density of 1.10-1.20, and then spray drying it to obtain a powdered extract. The inlet air temperature of the spray dryer is 120-130°C and the outlet air temperature is 60-70°C.

[0020] In some embodiments, microcapsule encapsulation includes: mixing a concentrated and dried extract with a wall material in a ratio of 1:3 to 1:5, adding water to form a suspension, and preparing microcapsules using a spray condensation method. The wall material is composed of maltodextrin and gum arabic mixed in a mass ratio of 1:1.

[0021] Another embodiment of the present invention provides the application of the above-mentioned Asteraceae composition in cosmetics, specifically in firming, anti-wrinkle, and barrier-repairing cosmetics.

[0022] The above-mentioned Asteraceae composition is added at a rate of 0.1-10% in leave-on and rinse-off cosmetics. In this application, the dosage can be flexibly adjusted according to the cosmetic formulation and efficacy requirements, and it is suitable for various products such as face creams, lotions, serums, and masks.

[0023] Another embodiment of the present invention provides a firming, anti-wrinkle, and barrier-repairing cosmetic, comprising the above-mentioned Asteraceae composition.

[0024] In some embodiments, the amount of the asteraceae composition added to the cosmetic is 0.1-10%.

[0025] In some embodiments, the cosmetic product includes a face cream, lotion, serum, or mask.

[0026] In some embodiments, the above-mentioned Asteraceae composition is used in cosmetics to achieve the dual effects of firming and anti-wrinkle and skin barrier repair. After continuous use for 7 days, the skin's transepidermal water loss rate is improved by ≥42%, the facial redness value is improved by ≥54%, and the skin hemoglobin EI value is improved by ≥43%.

[0027] The following are examples and comparative examples.

[0028] The method for preparing the compound compositions in the examples and comparative examples is characterized by comprising the following steps: (1) Weigh dipropylene glycol, co-solvent and water, and stir for 10 min at 30℃ and 400 r / min to obtain the basic carrier solution.

[0029] (2) Add the Asteraceae extract to the base carrier solution and stir at 30°C and 400r / min for 30min.

[0030] (3) Sterilize by filtration using a 0.22μm microporous membrane, and dispense under aseptic conditions to obtain the product.

[0031] The mass percentages of the compound compositions in the examples and comparative examples are shown in Table 1. The sum of the mass percentages of the components in each example and comparative example is 100%.

[0032] Table 1

[0033] Test case (1) Test object One hundred and eighty volunteers aged 18-55 were randomly divided into six groups of 30 each, covering individuals with sensitive skin and those experiencing early signs of aging. There were no significant differences in skin type and age distribution among the groups (P>0.05). Each group used the corresponding test samples from the example and comparative studies, applying them twice daily (morning and evening) for seven consecutive days. The test sample was a serum, comprising 2% by weight of a compound composition, with the remainder consisting of serum excipients.

[0034] (2) Transepidermal water loss rate (TEWL): The TEWL values ​​were measured before use and 7 days after use using a transepidermal water loss meter to calculate the improvement rate.

[0035] (3) Facial red area value and heme EI value: The proportion of facial red area and heme EI value were tested before use and 7 days after use using a skin color difference analyzer, and the improvement rate was calculated.

[0036] (4) Muscle contraction frequency: The skin neuromuscular contraction frequency was tested 24 hours after use using a skin biomechanical sensor to evaluate the firming effect.

[0037] The test results are shown in Table 2.

[0038] Table 2

[0039] As can be seen from Table 1, the compound composition of the present invention has better firming, anti-wrinkle and barrier repair effects.

[0040] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0041] For those skilled in the art, based on the ideas of this invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of this invention.

Claims

1. A composition of the Asteraceae family, characterized in that, The product comprises the following components in the indicated mass percentages: 1-5% of *Chrysanthemum indicum* extract, 1-5% of *Echinacea purpurea* extract, ≤2% of auxiliary Asteraceae extracts, 5-20% of water, 2-8% of cosolvent, and the balance being dipropylene glycol; the cosolvent includes at least one of polysorbate-20 and PEG-40 hydrogenated castor oil; the auxiliary Asteraceae extracts include one or more of daisy extract, chamomile extract, calendula extract, sunflower extract, atractylodes macrocephala extract, and atractylodes lancea extract.

2. A method for preparing the Asteraceae composition according to claim 1, characterized in that, Includes the following steps: (1) Weigh dipropylene glycol, co-solvent and water, and stir for 10-20 min at 25-35℃ and 300-500 r / min to obtain the basic carrier solution; (2) Add chrysanthemum extract, purple coneflower extract and auxiliary chrysanthemum extract to the base carrier solution, and stir at 25-35℃ and 300-500r / min for 20-30min; (3) Sterilize by filtration using a 0.22μm microporous membrane, and dispense under aseptic conditions to obtain the product.

3. The method for preparing the Asteraceae composition as described in claim 2, characterized in that, Extraction methods for various Asteraceae plant extracts include raw material pretreatment, nanoscale extraction, filtration purification, concentration and drying, and microencapsulation steps.

4. The method for preparing the Asteraceae composition as described in claim 3, characterized in that, The raw material pretreatment includes: selecting medicinal parts of plants in the Asteraceae family, washing and drying them, and then pulverizing them to 20-40 mesh to obtain raw material powder; wherein, the medicinal parts of plants in the Asteraceae family include: flowers of Globe amaranth, roots and flowers of Echinacea purpurea, flowers of daisy, flowers of chamomile, flowers of calendula, seeds of sunflower, rhizomes of Atractylodes macrocephala, and rhizomes of Atractylodes lancea.

5. The method for preparing the Asteraceae composition as described in claim 3, characterized in that, The nanoscale extraction uses a 50-70% ethanol aqueous solution as the extraction solvent, with a raw material powder to solvent mass-volume ratio of 1:10-1:20, an extraction temperature of 35-45℃, and a pressure of 0.3-0.5MPa.

6. The method for preparing the Asteraceae composition as described in claim 3, characterized in that, The filtration and purification process includes: after extraction, filtering through a 200-mesh filter to remove residue, and then filtering the filtrate through a 0.45μm microporous membrane to obtain purified filtrate.

7. The method for preparing the Asteraceae composition as described in claim 3, characterized in that, The concentration and drying process includes: concentrating the purified filtrate under reduced pressure at a vacuum of -0.08 to -0.09 MPa and a temperature of 40-50°C to obtain an extract with a relative density of 1.10-1.20, and then spray drying it to obtain a powdered extract. The inlet air temperature of the spray dryer is 120-130°C and the outlet air temperature is 60-70°C.

8. The method for preparing the Asteraceae composition as described in claim 3, characterized in that, The microcapsule encapsulation process involves: mixing a concentrated and dried extract with a wall material in a ratio of 1:3 to 1:5, adding water to form a suspension, and preparing microcapsules using a spray condensation method. The wall material is composed of maltodextrin and gum arabic mixed in a mass ratio of 1:

1.

9. The use of the Asteraceae composition of claim 1 in a firming, anti-wrinkle, and barrier-repairing cosmetic.

10. A firming, anti-wrinkle, and barrier-repairing cosmetic, characterized in that, The cosmetic includes the Asteraceae composition of claim 1, wherein the Asteraceae composition is added in an amount of 0.1-10%.

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