Medical anti-aging and antibacterial rubber and preparation method thereof

Abstract

The application relates to a medical anti-aging antibacterial rubber and a preparation method thereof. The medical anti-aging antibacterial rubber is prepared from the following components: 70-100 parts of brominated butyl rubber, 10-20 parts of white carbon black, 5-20 parts of modified silicon carbide, 0.1-0.6 parts of a surfactant, 1-4 parts of a catalyst, 1-3 parts of a silane coupling agent, 8-10 parts of zinc oxide, 4-10 parts of an accelerator, 0.1-0.5 parts of an anti-aging agent, 20-35 parts of a toughening agent and 3-8 parts of an antibacterial agent. The brominated butyl rubber, the white carbon black, the nano silicon carbide whisker, the surfactant, the silane coupling agent, the zinc oxide, the accelerator, the catalyst, the anti-aging agent, the toughening agent and the antibacterial agent are uniformly mixed according to the proportion, heated and mixed at 60-80 DEG C for 10-20 min, and then the mixed rubber is calendered; after vulcanization treatment at 170-180 DEG C for 10-25 min, the medical anti-aging antibacterial rubber is obtained.

Description

Technical Field

[0001] This application relates to the field of rubber materials, and more specifically, to a medical anti-aging and antibacterial rubber and its preparation method. Background Technology

[0002] Butyl rubber stoppers, due to their superior airtightness, heat resistance, acid and alkali resistance, and chemical inertness, quickly replaced natural rubber stoppers in the pharmaceutical packaging field. Halogenated butyl rubber stoppers are currently one of the most widely used pharmaceutical packaging materials. As a type of rubber material that comes into direct contact with drugs, halogenated butyl rubber has high performance requirements in the pharmaceutical industry.

[0003] Chinese pharmaceutical packaging industry standards such as YBB00042005-2015 "Halogenated Butyl Rubber Stoppers for Injection Solutions" and YBB00052005-2015 "Halogenated Butyl Rubber Stoppers for Sterile Powders for Injection" have certain testing compliance requirements for factors that directly affect the performance of packaged drugs, such as the sealing performance, needle puncture shedding, specific migration of zinc ions, and volatile sulfides of halogenated butyl rubber stoppers.

[0004] Existing rubber stoppers may experience sealing performance due to heat and oxygen aging and light aging during long-term use, resulting in poor antibacterial effect, drug contamination, toxicity or pyrogens, affecting the chemical and physical stability of the preparation, and sometimes even causing serious toxic side effects. Summary of the Invention

[0005] In order to improve the anti-aging and antibacterial properties of medical rubber, this application provides a medical anti-aging and antibacterial rubber and its preparation method.

[0006] In a first aspect, this application provides a medical anti-aging and antibacterial rubber, which adopts the following technical solution:

[0007] A medical anti-aging and antibacterial rubber is prepared from the following raw materials: 70-100 parts of brominated butyl rubber, 10-20 parts of silica, 5-20 parts of nano-silicon carbide whiskers, 0.1-0.6 parts of surfactant, 1-4 parts of catalyst, 1-3 parts of silane coupling agent, 8-10 parts of zinc oxide, 4-10 parts of accelerator, 0.1-0.5 parts of anti-aging agent, 20-35 parts of toughening agent, and 3-8 parts of antibacterial agent.

[0008] By adopting the above technical solutions, halogenated butyl rubber can be vulcanized using a cleaner sulfur-free vulcanization system, which is suitable for butyl rubber with good sealing performance and acid and alkali resistance. Brominated butyl rubber was specifically selected because the C-Br bond is highly active, resulting in a faster vulcanization speed.

[0009] Silane coupling agents readily combine with silicon-containing substances, enabling better adhesion to silica and nano-silicon carbide whiskers, and effectively crosslinking brominated butyl rubber to promote efficient interfacial fusion.

[0010] The fillers selected are silica and nano-silicon carbide whiskers. Silica has a good coupling effect with silane coupling agents, increasing the adhesion between the filler and the rubber. However, silica contains hydrophilic silanol groups on its surface, which strongly adsorb accelerators, thus reducing the vulcanization rate. Therefore, by incorporating nano-silicon carbide whiskers into the silica, not only is the amount of silica reduced, minimizing its impact on the vulcanization rate, but the different thermal expansion coefficients of nano-silicon carbide whiskers and rubber materials also allow for better interfacial adhesion with brominated butyl rubber, enabling it to withstand greater stress. When microcracks appear in the composite material, closing stress can be applied to the cracked surface to prevent further propagation of the microcracks, thereby strengthening and toughening the material while also providing some anti-aging effects.

[0011] The addition of anti-aging agents can delay or inhibit the gradual decline in the mechanical properties and elasticity of rubber products over time, as well as the aging process of rubber hardening, brittleness, or cracking, thus extending the service life of rubber.

[0012] The addition of toughening agents can improve the fluidity of materials during processing and enhance their processing performance. By controlling the amount of toughening agent added, the tensile strength, hardness, and other properties of the material can be adjusted.

[0013] The addition of antibacterial agents can effectively inhibit the growth and reproduction of bacteria, fungi and viruses, ensuring the safety, cleanliness and environmental protection requirements of medical rubber.

[0014] Through the combined effect of the above components, the basic mechanical properties, compression set, antibacterial and anti-aging properties, needle puncture retention properties, and sealing properties of medical anti-aging and antibacterial rubber are improved, better meeting the application requirements in the medical field.

[0015] In one specific implementation scheme, the anti-aging agent includes light stabilizer 770, anti-aging agent 264 and antioxidant 1010, wherein the mass ratio of light stabilizer 770, anti-aging agent 264 and antioxidant 1010 is 1:1.5-1.7:2.2-2.8.

[0016] By adopting the above technical solution, starting from the structure and properties of rubber, and by organically compounding anti-aging agents with different anti-aging effects, an anti-aging agent that can specifically prevent the most common light aging, thermo-oxidative aging, and mechanical stress aging of rubber materials is obtained, so that they can produce a synergistic effect to ensure the anti-aging effect and thus extend the service life of rubber.

[0017] In one specific implementation, the antibacterial agent is a nano-titanium dioxide or nano-silver antibacterial agent.

[0018] By adopting the above technical solution and adding nano-titanium dioxide or nano-silver antibacterial agents, which have a large specific surface area, the growth and reproduction of viruses, bacteria and fungi can be more comprehensively inhibited and killed, ensuring the safety, cleanliness and environmental protection requirements of medical rubber.

[0019] In one specific implementation, the toughening agent is polyisobutylene and paraffin oil, and the mass ratio of polyisobutylene to paraffin oil is 1:1.5-2.2.

[0020] By employing the above technical solutions, the addition of paraffin oil can adjust the tensile strength, hardness, and other properties of the material, improving its toughness and processability. However, excessive paraffin oil content can reduce the modulus and cohesive energy of the brominated butyl rubber blend system, making the brominated butyl rubber composite material prone to breakage. Polyisobutylene is a polymer formed by the ion polymerization of isobutylene monomers. Its molecular chain has a linear saturated structure without long branches or double bonds. Therefore, the linear molecular chain segments give it a certain tensile strength and elastic modulus, which can better compensate for the reduction in modulus and cohesive energy caused by excessive paraffin oil content. In addition, polyisobutylene has a similar structure to brominated butyl rubber, strong affinity, and symmetrically arranged side methyl groups between the polyisobutylene molecular chains. The special structure of polyisobutylene gives it a low gas permeability and excellent airtightness. Therefore, a certain proportion of composite polyisobutylene and paraffin oil can effectively maintain airtightness while enhancing the basic mechanical properties and needle puncture resistance of the composite rubber.

[0021] In one specific implementation, the silane coupling agent is one of vinyltrimethoxysilane, vinyltritert-butoxysilane, and vinyltritert-butylperoxysilane; the accelerator is one of 2-mercaptobenzothiazole, dibenzothiazole disulfide, and N,N-dimethyl-2-benzothiazole sulfenamide; the surfactant is one of polyvinylpyrrolidone, sodium alginate, and polyethylene glycol methyl ether acrylate; and the catalyst is dibutyltin dilaurate or stannous isooctanoate.

[0022] By employing the above technical solutions, the vinyl silane coupling agent molecule contains various bond structures such as hydrogen bonds and silicon-oxygen bonds. These bond structures greatly enhance the heat resistance, water resistance, and corrosion resistance of the vinyl silane coupling agent. Vinyl alkyl coupling agents can enhance the bond strength between fillers and brominated butyl rubber materials, giving the composite rubber better mechanical properties and improving the material's water resistance, heat resistance, and corrosion resistance. Zinc oxide, in combination with accelerators, promotes the vulcanization reaction while also having a certain anti-coking effect. Surfactants help enhance the chemical activity of the surface of silica and nano-silicon carbide whiskers, while catalysts with high catalytic activity and selectivity can ensure a strong bond between the rubber and the filler.

[0023] In one specific feasible implementation, the nano-silicon carbide whiskers are prepared by the following method:

[0024] Nanocrystalline cellulose was dissolved in distilled water, heated to 40-80℃, and an acidic catalyst was added. The mixture was stirred to obtain a mixed solution 1. The mass ratio of nanocrystalline cellulose to acidic catalyst was 1:2.2-5.8.

[0025] Dissolve 3-methylmethoxysilane in anhydrous ethanol, then add it dropwise to mixed solution one, and react at 30-90℃ for 4-8 hours; the mass ratio of nanocrystalline cellulose to 3-methylmethoxysilane is 1:14-32;

[0026] The obtained product was centrifuged, and the precipitate was washed with anhydrous ethanol. It was then heated to 800-1200℃ under an argon atmosphere and maintained for 10-15 hours to obtain nano-silicon carbide whiskers.

[0027] By adopting the above technical solution, the nano-silicon carbide whiskers have a fine structure and high strength and high elastic modulus, which can improve the mechanical properties, high temperature resistance and corrosion resistance of the material. As a filler, the nano-silicon carbide whiskers can withstand stress and add closing stress to the surface of the interface crack zone to prevent crack propagation and extend the service life of the composite rubber.

[0028] In one specific implementation, the acidic catalyst is either glacial acetic acid or formic acid.

[0029] By adopting the above technical solution, glacial acetic acid or formic acid is used as a catalyst. The active groups of glacial acetic acid or formic acid are more likely to react and form hydrogen bonds, thereby increasing the reaction rate, controlling the number of nucleation and growth rate of whiskers, reducing the residual carbon content of whiskers, and improving the straightness and purity of whiskers.

[0030] In one specific implementation, the centrifugation is performed at 5000-10000 rpm for 10-20 minutes.

[0031] By adopting the above technical solution, incompletely reacted and insoluble impurities can be effectively separated, ensuring the crystal nucleus growth environment.

[0032] Secondly, this application provides a method for preparing medical anti-aging and antibacterial rubber, which adopts the following technical solution: A method for preparing medical anti-aging and antibacterial rubber includes the following steps:

[0033] According to the formula, brominated butyl rubber, silica, nano-silicon carbide whiskers, surfactant, silane coupling agent, zinc oxide, accelerator, catalyst, anti-aging agent, toughening agent and antibacterial agent are mixed evenly and heated at 60-80℃ for 10-20 minutes to obtain a compound. After calendering, it is vulcanized at 170-180℃ for 10-25 minutes to obtain medical anti-aging and antibacterial rubber.

[0034] By adopting the above technical solutions, it is beneficial to fully mix and vulcanize the mixture, enhance the performance of the composite rubber, and obtain medical anti-aging and antibacterial rubber that meets the standards of the medical industry.

[0035] In summary, this application includes at least one of the following beneficial technical effects:

[0036] 1. This application improves the antibacterial properties of rubber by adding anti-aging agents and antibacterial agents to the rubber system. Simultaneously, the fillers selected are silica and nano-silicon carbide whiskers. Silica has a good coupling effect with silane coupling agents, increasing the adhesion between the filler and the rubber. However, silica contains hydrophilic silanol groups on its surface and has a strong adsorption effect on accelerators, which reduces the vulcanization rate. Therefore, by incorporating nano-silicon carbide whiskers into the silica mixture, not only is the amount of silica reduced, minimizing its impact on the vulcanization rate, but the nano-silicon carbide whiskers themselves have a fine structure and high strength and high elastic modulus, improving the mechanical properties, high temperature resistance, and corrosion resistance of the material. The different coefficients of thermal expansion between nano-silicon carbide whiskers and rubber materials allow for interfacial adhesion with brominated butyl rubber, enabling it to withstand greater stress, thereby improving the rubber's resistance to environmental stress. Furthermore, when the rubber begins to age and the interface cracks, closing stress can be applied to the surface of the cracked area to prevent crack propagation and extend the service life of the composite rubber.

[0037] 2. Vinyl silane coupling agents contain various bond structures, including hydrogen bonds and silicon-oxygen bonds, which endow them with excellent heat resistance, water resistance, and corrosion resistance. Vinyl alkyl coupling agents can enhance the bond strength between fillers and brominated butyl rubber materials, resulting in better modified properties of the composite rubber and improved water resistance, heat resistance, and corrosion resistance. When used in conjunction with accelerators, vinyl silane coupling agents promote the vulcanization reaction while also providing some anti-scorching effects.

[0038] 3. Based on the structure and properties of rubber, by organically compounding anti-aging agents with different anti-aging effects, we can obtain anti-aging agents that can specifically prevent the most common light aging, thermo-oxidative aging, and mechanical stress aging of rubber materials, so that they can produce a synergistic effect to ensure the anti-aging effect and thus extend the service life of rubber. Detailed Implementation

[0039] The present application will be further described in detail below with reference to the embodiments.

[0040] The brominated butyl rubber used in the following examples is Polysar 2030, manufactured by Bayer AG, Germany, with a Mooney viscosity of ML1. +4 125℃ =27-36, other raw materials can be obtained commercially.

[0041] Preparation Example

[0042] Preparation Example 1

[0043] Dissolve nanocrystalline cellulose in distilled water, heat to 40°C, add glacial acetic acid, and mix well to obtain mixture one. The mass ratio of nanocrystalline cellulose to glacial acetic acid is 1:2.2.

[0044] 3-Methylmethoxysilane was dissolved in anhydrous ethanol and then added dropwise to mixed solution one. The reaction was carried out at 30°C for 4 hours. The mass ratio of nanocrystalline cellulose to 3-methylmethoxysilane was 1:14.

[0045] The obtained product was centrifuged at 5000 rpm for 10 minutes, and the precipitate was washed with anhydrous ethanol. It was then heated to 800℃ under an argon atmosphere and maintained for 10 hours to obtain nano-silicon carbide whiskers.

[0046] Preparation Example 2

[0047] Nanocrystalline cellulose was dissolved in distilled water, heated to 60°C, formic acid was added, and the mixture was stirred to obtain a mixed solution 1. The mass ratio of nanocrystalline cellulose to formic acid was 1:5.8.

[0048] 3-Methylmethoxysilane was dissolved in anhydrous ethanol and then added dropwise to mixed solution one. The reaction was carried out at 90°C for 8 hours. The mass ratio of nanocrystalline cellulose to 3-methylmethoxysilane was 1:32.

[0049] The product was centrifuged at 10,000 rpm for 20 minutes, and the precipitate was washed with anhydrous ethanol. The product was then heated to 800°C under an argon atmosphere and maintained for 10 hours to obtain nano-silicon carbide whiskers.

[0050] Preparation Example 3

[0051] Dissolve nanocrystalline cellulose in distilled water, heat to 80°C, add glacial acetic acid, and mix well to obtain mixture one. The mass ratio of nanocrystalline cellulose to glacial acetic acid is 1:5.8.

[0052] 3-Methylmethoxysilane was dissolved in anhydrous ethanol and then added dropwise to mixed solution one. The reaction was carried out at 90°C for 4 hours. The mass ratio of nanocrystalline cellulose to 3-methylmethoxysilane was 1:32.

[0053] The obtained product was centrifuged at 5000 rpm for 20 minutes, and the precipitate was washed with anhydrous ethanol. It was then heated to 1000℃ under an argon atmosphere and maintained for 10 hours to obtain nano-silicon carbide whiskers.

[0054] Example

[0055] Example 1

[0056] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 70g of brominated butyl rubber, 10g of silica, 5g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.1g of polyvinylpyrrolidone, 1g of dibutyltin dilaurate, 1g of vinyltrimethoxysilane, 8g of zinc oxide, 4g of 2-mercaptobenzothiazole, 0.1g of anti-aging agent, 20g of toughening agent, and 3g of nano-titanium dioxide. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:1.5:2.2, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0057] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent and nano-titanium dioxide were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 60°C for 15 min to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 170°C for 10 min to obtain medical anti-aging and antibacterial rubber.

[0058] Example 2

[0059] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 75g of brominated butyl rubber, 12g of silica, 10g of nano-silicon carbide whiskers prepared in Preparation Example 1, 0.2g of sodium alginate, 1.2g of stannous isooctanoate, 1.3g of vinyltritert-butoxysilane, 10g of zinc oxide, 5g of dibenzothiazole disulfide, 0.5g of anti-aging agent, 23g of toughening agent, and 5g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, antioxidant 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:1.5.

[0060] During preparation, nano-silicon carbide whiskers, silica, sodium alginate, vinyltritert-butoxysilane, stannous isooctanoate, zinc oxide, dibenzothiazole disulfide, anti-aging agent, toughening agent, and nano-silver antibacterial agent were added to brominated butyl rubber in proportion. The mixture was heated and kneaded at 68°C for 10 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 175°C for 10 minutes to obtain medical anti-aging and antibacterial rubber.

[0061] Example 3

[0062] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 100g of brominated butyl rubber, 18g of silica, 20g of nano-silicon carbide whiskers prepared in Preparation Example 1, 0.5g of sodium alginate, 3g of stannous isooctanoate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of N,N-dimethyl-2-benzothiazolyl sulfenamide, 0.1g of anti-aging agent, 30g of toughening agent, and 6g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, antioxidant 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0063] During preparation, nano-silicon carbide whiskers, silica, sodium alginate, vinyltrimethoxysilane, N,N-dimethyl-2-benzothiazolyl sulfenamide, zinc oxide, stannous isooctanoate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 70°C for 20 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 180°C for 25 minutes to obtain medical anti-aging and antibacterial rubber.

[0064] Example 4

[0065] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 8g of 2-mercaptobenzothiazole, 10g of zinc oxide, 0.5g of anti-aging agent, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:1.5:2.2, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0066] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 70°C for 20 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0067] Example 5

[0068] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 92g of brominated butyl rubber, 18g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.5g of polyvinylpyrrolidone, 4g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 10g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 35g of toughening agent, and 7g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:1.5.

[0069] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 80°C for 20 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 180°C for 10 minutes to obtain medical anti-aging and antibacterial rubber.

[0070] Example 6

[0071] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0072] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 75°C for 20 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0073] Example 7

[0074] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 30g of toughening agent, and 3g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:1.5:2.2, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0075] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and kneaded at 70°C for 8 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0076] Example 8

[0077] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of modified silicon carbide obtained in Preparation Example 2, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, antioxidant 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0078] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 2 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 75°C for 20 minutes to obtain a compound that was fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0079] Example 9

[0080] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of modified silicon carbide whiskers obtained in Preparation Example 3, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, antioxidant 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0081] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 3 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 75°C for 20 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0082] Example 10

[0083] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:1.5:2.2, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:1.5.

[0084] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 70°C for 20 minutes to obtain a compound that was fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0085] Example 11

[0086] A medical anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of antioxidant 1010, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0087] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, antioxidant 1010, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 70°C for 20 minutes to obtain a compound that was fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0088] Example 12

[0089] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:0.5:1, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0090] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 75°C for 20 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0091] Example 13

[0092] A medical anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 30g of paraffin oil, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, antioxidant 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8.

[0093] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 75°C for 20 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0094] Example 14

[0095] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers prepared in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:3:5, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0096] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 75°C for 20 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0097] Example 15

[0098] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:5.

[0099] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 75°C for 20 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0100] Example 16

[0101] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:0.5.

[0102] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 75°C for 20 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0103] Comparative Example

[0104] Comparative Example 1

[0105] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 50g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0106] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 75°C for 20 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0107] Comparative Example 2

[0108] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.8g of anti-aging agent, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0109] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent obtained from Preparation Example 1 were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 75°C for 20 minutes to obtain the compound, which was then fed into a calender for calendering. The compound was then vulcanized at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0110] Comparative Example 3

[0111] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 35g of silica, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0112] During preparation, silica, brominated butyl rubber, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, toughening agent, and nano-silver antibacterial agent are mixed in proportion and heated at 75°C for 20 minutes. The resulting compound is then fed into a calender for calendering. The compound is then vulcanized at 170°C for 20 minutes to obtain medical-grade anti-aging and antibacterial rubber.

[0113] Comparative Example 4

[0114] A medical-grade anti-aging and antibacterial rubber is prepared from the following raw materials: 90g of brominated butyl rubber, 20g of silica, 15g of nano-silicon carbide whiskers obtained in Preparation Example 1, 0.6g of polyvinylpyrrolidone, 3g of dibutyltin dilaurate, 3g of vinyltrimethoxysilane, 10g of zinc oxide, 8g of 2-mercaptobenzothiazole, 0.5g of anti-aging agent, 30g of toughening agent, and 8g of nano-silver antibacterial agent. The anti-aging agent is prepared by mixing light stabilizer 770, anti-aging agent 264, and antioxidant 1010 in a mass ratio of 1:1.7:2.8, and the toughening agent is prepared by mixing polyisobutylene and paraffin oil in a mass ratio of 1:2.2.

[0115] During preparation, nano-silicon carbide whiskers, fumed silica, polyvinylpyrrolidone, vinyltrimethoxysilane, zinc oxide, 2-mercaptobenzothiazole, dibutyltin dilaurate, anti-aging agent, and toughening agent were added to brominated butyl rubber in proportion. The mixture was heated and mixed at 75°C for 20 minutes to obtain the compound. The compound was then fed into a calender for calendering and vulcanization at 170°C for 20 minutes to obtain medical anti-aging and antibacterial rubber.

[0116] Performance testing

[0117] Based on the basic mechanical requirements that rubber stopper products should meet, and in accordance with the standard provisions of YBB00052005-2015 and YBB00042005-2015, the performance of the rubber stoppers prepared in each embodiment and comparative example was tested, and the results are shown in Table 1 and Table 2.

[0118] In the chemical performance testing, the zinc ion migration was detected. The test solution was prepared according to the standard YBB00052005-2015, and a quantitative detection method was used to calculate the zinc ion content in the test solution. The antibacterial rate was determined by testing the inhibition of the average number of *Escherichia coli* and *Staphylococcus aureus*, according to JC / T897-2002. The prepared anti-aging antibacterial rubber was placed under 5000 Lux light intensity for 30 days, and then the changes in sealing performance, tensile strength, and antibacterial performance were tested.

[0119] Table 1 Results of Physical Performance Tests

[0120]

[0121]

[0122] Table 2 Results of Antioxidant Performance Test

[0123]

[0124]

[0125] Referring to Table 1, in Examples 10 to 16, compared with Comparative Example 1, the prepared medical anti-aging and antibacterial rubber exhibited appropriate mechanical properties of the rubber product. It can be seen that as the proportion of toughening agent added increases, the tensile strength of the medical anti-aging and antibacterial rubber increases and the toughness increases. However, if too much toughening agent is added, the tensile strength of the composite rubber material will become worse, which will also affect the overall performance test and make it unqualified.

[0126] In Examples 1 to 4, as the amount of nano-silicon carbide whiskers increased, the Shore hardness of the medical anti-aging and antibacterial rubber system also increased continuously, and the puncture force met the requirements of the national pharmaceutical packaging material regulations for puncture bottle caps, indicating that the prepared rubber material has superior mechanical properties that meet the regulations.

[0127] Referring to Table 1, in Examples 1 to 16, compared with Comparative Example 3, the addition of nano-silicon carbide whiskers to the rubber substrate not only greatly improves the hardness and toughness of the material, but also has a significant impact on the formation of a dense rubber layer. In the rubber test of Comparative Example 3, methylene blue leakage occurred, which is mainly attributed to the fact that Comparative Example 3 did not contain nano-silicon carbide whiskers. Nano-silicon carbide whiskers themselves have a fine structure and high strength and high elastic modulus. Nano-silicon carbide whiskers and silica can enhance the bonding strength between the filler and the brominated butyl rubber material through vinyl alkyl coupling agents, enhance the airtightness of the system, and achieve efficient composite of raw materials used in the preparation of rubber. The raw materials are not easy to precipitate or decompose at high temperatures, resulting in a high standard of needle punch shedding rate.

[0128] Referring to Table 2, in Examples 1 to 16, compared with Comparative Example 4, the addition of antibacterial agents can effectively inhibit the average number of Escherichia coli and the growth and reproduction of Staphylococcus aureus, ensuring the safety, cleanliness and environmental protection requirements of medical rubber.

[0129] Referring to Tables 2 and 1, in Examples 6 to 9, compared with Example 11, based on the structure and properties of rubber, anti-aging agents with different anti-aging effects were organically compounded to obtain anti-aging agents that can specifically prevent the most common aging properties of rubber materials, such as light aging, thermo-oxidative aging, and mechanical stress aging, thus enhancing the anti-aging performance of the rubber system. The prepared anti-aging and antibacterial rubber was placed under 5000 Lux light intensity for 30 days, and the changes in sealing performance, tensile strength, and antibacterial performance were tested again. The results showed that under abnormal extreme photo-oxidation conditions, the sealing performance, tensile strength, and antibacterial performance of the prepared composite rubber remained at a basically equivalent level compared with those before photo-oxidation. This indicates that the synergistic effect produced by the organic compounding of anti-aging agents with different anti-aging effects can maintain the anti-aging performance of the rubber system in a long-term and stable manner, effectively extending the service life of the rubber.

[0130] The raw materials used in the preparation of the medical anti-aging and antibacterial rubber do not contain sulfur or other components that are easily released or decomposed at high temperatures. They have no potential toxicity to drugs and human tissues, further improving the safety and quality assurance of rubber products. They also have strong tensile strength and hardness, and good bactericidal effect. This anti-aging and antibacterial rubber, when used in medical applications, can effectively ensure drug safety while also having a good anti-aging effect, which can extend the service life of rubber. Therefore, it meets the needs of actual production and has a good market prospect.

[0131] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A medical anti-aging and antibacterial rubber, characterized in that: The raw materials for preparation include the following components: 70-100 parts of brominated butyl rubber, 10-20 parts of silica, 5-20 parts of nano-silicon carbide whiskers, 0.1-0.6 parts of surfactant, 1-4 parts of catalyst, 1-3 parts of silane coupling agent, 8-10 parts of zinc oxide, 4-10 parts of accelerator, 0.1-0.5 parts of anti-aging agent, 20-35 parts of toughening agent, and 3-8 parts of antibacterial agent; the anti-aging agent includes light stabilizer 770, anti-aging agent 264, and antioxidant 1010, with a mass ratio of 1:1.5-1.7:2.2-2.8; the antibacterial agent is nano-titanium dioxide or nano-silver antibacterial agent; the toughening agent is polyisobutylene and paraffin oil, with a mass ratio of 1:1.

5. -2.2; The nano-silicon carbide whiskers are prepared by the following method: nano-microcrystalline cellulose is dissolved in distilled water, heated to 40-80℃, an acidic catalyst is added, and mixed to obtain a mixed solution. The mass ratio of nano-microcrystalline cellulose to acidic catalyst is 1:2.2-5.8; 3-methylmethoxysilane is dissolved in anhydrous ethanol, and then added dropwise to the mixed solution. The reaction is carried out at 30-90℃ for 4-8 hours. The mass ratio of nano-microcrystalline cellulose to 3-methylmethoxysilane is 1:14-32; the obtained product is centrifuged at 5000-10000 rpm for 10-20 minutes, and the precipitate is washed with anhydrous ethanol; the mixture is heated to 800-1200℃ under an argon atmosphere and maintained for 10-15 hours to obtain nano-silicon carbide whiskers; the acidic catalyst is either glacial acetic acid or formic acid.

2. The medical anti-aging and antibacterial rubber according to claim 1, characterized in that: The silane coupling agent is one of vinyltrimethoxysilane, vinyltritert-butoxysilane, and vinyltritert-butylperoxysilane; the accelerator is one of 2-mercaptobenzothiazole, dibenzothiazole disulfide, and N,N-dimethyl-2-benzothiazole sulfenamide; the surfactant is one of polyvinylpyrrolidone, sodium alginate, and polyethylene glycol methyl ether acrylate; and the catalyst is dibutyltin dilaurate or stannous isooctanoate.

3. The method for preparing a medical anti-aging and antibacterial rubber according to any one of claims 1-2, characterized in that: The process includes the following steps: according to the specified ratio, brominated butyl rubber, silica, nano-silicon carbide whiskers, surfactant, silane coupling agent, zinc oxide, accelerator, catalyst, anti-aging agent, toughening agent and antibacterial agent are mixed evenly, heated and kneaded at 60-80℃ for 10-20 minutes to obtain a compound, calendered and molded, and then vulcanized at 170-180℃ for 10-25 minutes to obtain medical anti-aging and antibacterial rubber.

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