A fungicidal composition containing tetrafluthrimazole and metrafenone

Abstract

This application relates to a fungicide composition containing tetraflufenazole and benomyl, the composition comprising: (a) a liquid tetraflufenazole active ingredient at room temperature; (b) a solid benomyl active ingredient at room temperature; (c) a [2,4,6-tris(1-phenylethyl)phenyl] ether polymerized from ethylene oxide and propylene oxide; and (d) an optional functional surfactant. The [2,4,6-tris(1-phenylethyl)phenyl] ether polymerized from ethylene oxide and propylene oxide effectively solves the storage compatibility problem between the two different forms of tetraflufenazole and benomyl, especially addressing the issue of mutual aggregation and sedimentation between the oil droplet form of tetraflufenazole and the particulate form of benomyl during dilution after storage, reducing the risk of sprayer clogging. The fungicide composition of this application effectively solves the compatibility problem between the liquid tetraflufenazole active ingredient and the solid benomyl, and the prepared product exhibits good performance in storage stability.

Description

Technical Field

[0001] This application relates to the field of pesticide formulation technology, and in particular to a fungicide composition containing tetraflufenazole and benomyl. Background Technology

[0002] Tetrafluoroether, chemically known as 2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl-1,1,2,2-tetrafluoroethyl ether, is a yellow viscous liquid with a water solubility of 156.6 mg / L in pure form. It belongs to the second-generation triazole fungicide class, containing fluorine in its molecular structure. Its fungicidal activity is 2-3 times that of the first generation, exhibiting a broad spectrum of activity, high efficiency, and a long-lasting effect of 4-6 weeks. It possesses both protective and curative effects and excellent systemic conductivity. It is suitable as a fungicide for cereal crops such as wheat, barley, oats, and rye; fruits such as bananas, grapes, pears, and apples; vegetables such as melons and beets; and ornamental plants. It can control diseases caused by fungi of the genera *Phenycetes*, *Phenycetes*, *Rhizopus*, *Sclerotium*, and *Syndrome*, such as wheat powdery mildew, wheat loose smut, wheat rust, wheat yellow smut, wheat glume blight, barley cloud stripe, barley loose smut, barley sheath blight, corn silk smut, sorghum silk smut, melon and fruit powdery mildew, banana leaf spot, apple leaf spot, pear scab, and grape powdery mildew. It can be used for foliar and stem treatment as well as seed treatment.

[0003] Benzophenone, chemically known as 3′-bromo-2,3,4,6′-tetramethoxy-2′,6-dimethylbenzophenone, is a white crystalline solid with a water solubility of 0.492 mg / L. Belonging to the benzophenone class of fungicides, it is primarily used to control powdery mildew and eye spot diseases in crops such as cereals, cucumbers, and grapes, and has attracted considerable attention due to its unique mechanism of action. It inhibits powdery mildew spore germination by interfering with the development and formation of appressorium during spore germination, acting on the entire life cycle of the fungus. Secondly, it interferes with the establishment and formation of polar actin tissue, disrupting and inhibiting the formation of apical cells of the mycelium, thereby hindering normal mycelial development and growth, inhibiting and preventing powdery mildew infection, and effectively controlling the damage caused by powdery mildew, demonstrating significant preventative and curative effects.

[0004] Currently, there are also patent reports on the fungicidal combination of tetraflufenicol and benomyl. CN103053538A discloses a fungicidal composition containing tetraflufenicol and benomyl, which has a significant synergistic effect on powdery mildew, improving the control effect. In addition, it can significantly reduce the amount of pesticides used in the field, effectively reducing environmental pollution and pesticide residues, lowering production and usage costs, and overcoming and delaying the development of disease resistance. Although the specification lists examples of preparing benomyl and tetraflufenicol suspensions and their water-dispersible particle sizes, it does not discuss or solve the storage compatibility issues of tetraflufenicol and benomyl active ingredients, or the aggregation and sedimentation problems of the composition during dilution after storage. CN102805083A discloses a composition of benomyl and triazole fungicides, which similarly does not discuss or solve the storage compatibility issues of tetraflufenicol and benomyl active ingredients, or the aggregation and sedimentation problems of the composition during dilution after storage.

[0005] Therefore, how to provide a stable, storage-compatible bactericidal composition of tetrafluoromethylene and benomyl, with good storage compatibility and dilution stability, and reduce or avoid dilution aggregation and sedimentation problems, has become a technical challenge that urgently needs to be solved for the composition. Summary of the Invention

[0006] This application provides a stable, storage-compatible fungicidal composition of tetrafluoroether and benomyl, which is physicochemically stable and has good storage and dilution stability, especially reducing or avoiding the problem of composition aggregation and sedimentation after dilution during storage.

[0007] This application provides a fungicide composition containing tetraflufenicol and benomyl, which contains the following components:

[0008] (a) The active tetrafluoroetherazole in liquid form at room temperature;

[0009] (b) Solid benomyl active product at room temperature;

[0010] (c) A [2,4,6-tris(1-phenylethyl)phenyl] ether polymerized from ethylene oxide and propylene oxide, with the general formula: C 30 H 30 O(C3H6O) m (C2H4O) n (I), where 1≤m≤50, 1≤n≤50;

[0011] (d) Optional functional surfactants; and

[0012] (e) Diluent.

[0013] The bactericidal composition containing tetraflufenicol and benomyl provided in this application effectively combines the liquid tetraflufenicol active ingredient and the solid benomyl active ingredient by adding a substance such as [2,4,6-tris(1-phenylethyl)phenyl] ether, which is polymerized from ethylene oxide and propylene oxide of Formula I. This improves the storage compatibility of the liquid tetraflufenicol active ingredient and the solid benomyl active ingredient. In particular, it improves the compatibility and stability of the liquid tetraflufenicol active ingredient and the solid benomyl active ingredient after dilution with water after storage, reduces the aggregation and sedimentation problem between tetraflufenicol oil droplets and benomyl particles, and finally obtains a qualified spray solution.

[0014] The [2,4,6-tris(1-phenylethyl)phenyl] ether of Formula I described in this application is a polymer of ethylene oxide and propylene oxide, wherein 1≤m≤50, 1≤n≤50; m can be selected from 1, 2, 5, 8, 10, 12, 15, 17, 19, 20, 21, 24, 26, 30, 35, 38, 42, 44, 45, 46, 48, 49 or 50; n can be selected from 1, 2, 5, 8, 10, 12, 15, 17, 19, 20, 21, 24, 26, 30, 35, 38, 42, 44, 45, 46, 48, 49 or 50; m and n are independent integers and can be the same or different, preferably the same. These [2,4,6-tris(1-phenylethyl)phenyl] ethers, polymerized from ethylene oxide and propylene oxide, are commercially available products, such as SOPROPHOR 796 / P (Solvay USA Inc.) and STEP-FLOW 1500 (Stepan Company).

[0015] The [2,4,6-tris(1-phenylethyl)phenyl] ether of formula I, polymerized from ethylene oxide and propylene oxide, used in this application typically has a structure of 1 ≤ m ≤ 50, 1 ≤ n ≤ 50, preferably 2 ≤ m ≤ 30, 2 ≤ n ≤ 30, and more preferably 5 ≤ m ≤ 25, 5 ≤ n ≤ 25. When m = 0 or n = 0, there is a risk of changes in functional properties due to the change in the general formula structure. On the other hand, when m > 50 or n > 50, there is a risk of difficulty in processing and plasticity.

[0016] Surprisingly, this application has found that by adding substances such as [2,4,6-tris(1-phenylethyl)phenyl] ether, which is polymerized from ethylene oxide and propylene oxide of Formula I, the storage compatibility problem of bactericidal compositions containing tetrafluoroetherazole and benomyl has been effectively solved, especially the problem of aggregation and sedimentation during the dilution process after the composition is stored.

[0017] The diluent refers to a substance that can dilute the concentration of the active ingredient, and can be a liquid diluent or a solid diluent. Liquid diluents are typically: aliphatic hydrocarbons such as cyclohexane or paraffins such as petroleum fractions, mineral and vegetable oils, alcohols such as ethanol or ethylene glycol and their ethers and esters, ketones such as methyl isobutyl ketone or cyclohexanone, highly polar solvents such as dimethyldecylamide and propylene carbonate, or water. Solid diluents are typically: for example, ammonium salts and pulverized natural minerals such as kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite, or silicates; and pulverized synthetic minerals such as highly dispersed silica, alumina, and silicates; particles of natural minerals such as kaolin, clay, talc, chalk, quartz, magnesia, montmorillonite, or diatomaceous earth; and particles of synthetic minerals such as highly dispersed silica, alumina, and silicates; pulverized and graded natural rocks such as calcite, marble, pumice, sepiolite, and dolomite; and inorganic synthetic particles and organic powders; and particles of organic products such as sawdust, coconut husks, corn cobs, and tobacco stalks; and inorganic salts such as ammonium sulfate and potassium sulfate; and organic substances such as sucrose, starch, lactose, urea, cellulose, polyvinyl alcohol, and methylpyrrolidone.

[0018] This application further includes one or more functional surfactants. Surfactants themselves are not biologically active, but they can enhance the dispersion, wetting, and emulsification effects of active ingredients in formulation systems, as well as the spreading, wetting, penetration, and adhesion properties of active ingredients on plant surfaces. They are functional adjuvant compounds that activate active molecules. These surfactants include anionic, nonionic, cationic, and amphoteric surfactants, block polymers, polyelectrolytes, and mixtures thereof. These surfactants can be used as emulsifiers, dispersants, wetting agents, defoamers, pH adjusters, antifreeze agents, thickeners, preservatives, antioxidants, colorants, etc.

[0019] Suitable emulsifiers include alkylphenol reactants with ethylene oxide and / or propylene oxide, ethoxylated nonylphenol, castor oil ethoxylates, mixtures of polyalkoxylated alcohols (Atlox 4894), alkyl calcium salts, alkylbenzene sulfonate calcium salts, sorbitol derivatives, or polyethylene oxide-sorbitol fatty acid esters.

[0020] Suitable dispersants are selected from one or more of the following: fatty alcohol ethoxylates, fatty alcohol alkoxylates, EO / PO block copolymers, sulfonic acids of ethoxylated alcohols, sulfosuccinates, fatty acid methyl taurate, tristyrylphenol ethoxylates and alkoxylates, trisec-butylphenol ethoxylates, sulfated cresol-formaldehyde condensates, sulfated condensates of naphthalene and alkylnaphthalenes, lignin sulfonates, ethoxylated fatty alcohols, phosphate esters of tristyrylphenol and trisec-butylphenol, as well as ethoxylated fatty alcohols, polyacrylic acid, polymethacrylic acid and acrylate copolymers, ether sulfates of tristyrylphenol and trisec-butylphenol, and polymer dispersants.

[0021] Suitable wetting agents are preferably anionic wetting agents, such as alkali metal, alkaline earth metal, or ammonium salts of anionic wetting agents. Suitable wetting agents are one or more of the following: naphthalene sulfonates (e.g., disodium methylene dinaphthalene sulfonate, sodium naphthalene sulfonate-formaldehyde condensate, ammonium naphthalene sulfonate-formaldehyde condensate), alkyl naphthalene sulfonates (e.g., sodium alkyl naphthalene sulfonate), benzene sulfonates, alkylbenzene sulfonates (e.g., sodium cumene sulfonate, potassium cumene sulfonate, sodium xylene sulfonate, sodium toluene sulfonate), alkane sulfonates (e.g., sodium tetradecene sulfonate), α-olefin sulfonates (e.g., sodium α-olefin sulfonate), sulfosuccinates (e.g., sodium dioctyl sulfosuccinate), alkyl phosphates (e.g., lauryl myristyl phosphate), and alkyl sulfates (e.g., sodium lauryl sulfate, sodium cetyl stearyl sulfate, sodium cetyl sulfate, sodium myristyl sulfate, sodium cetyl stearyl sulfate).

[0022] Suitable defoamers include silicone-based, low-carbon alcohol, and fatty acid salt defoamers.

[0023] Suitable pH adjusters include substances that can provide proton acids or proton bases, such as phosphoric acid, acetic acid, citric acid, sodium carbonate, sodium bicarbonate, potassium phosphate, potassium monohydrogen phosphate, and potassium dihydrogen phosphate.

[0024] Suitable antifreeze agents include all substances commonly used for this purpose in agricultural chemical compositions, preferably propylene glycol and / or ethylene glycol.

[0025] Suitable thickeners include all substances commonly used for this purpose in agricultural chemical compositions, preferably xanthan gum.

[0026] Suitable preservatives include all substances commonly used for this purpose in agricultural chemical compositions, preferably selected from the Proxel and / or Nipacide series of preservatives.

[0027] Suitable antioxidants include all substances commonly used for this purpose in agricultural chemical compositions, preferably 2,6-di-tert-butyl-4-methylphenol.

[0028] Suitable colorants include all substances commonly used for this purpose in agrochemical compositions, and preferably, the colorant is any one or a combination of at least two of titanium dioxide, zinc oxide, blue pigment, or Pigment Red BBN (i.e., fast red BBN).

[0029] Preferably, the bactericidal composition described in this application comprises the following components in weight percentage:

[0030] (a) 1-20% by weight of tetrafluoroether azole active liquid at room temperature;

[0031] (b) 1-50% by weight of benomyl active ingredient in solid form at room temperature;

[0032] (c) 2-15% by weight of [2,4,6-tris(1-phenylethyl)phenyl] ether of formula I, which is a polymer of ethylene oxide and propylene oxide;

[0033] (d) Optional functional surfactants in a weight percentage of 1-20%; and

[0034] (e) Diluent with a weight percentage of 15-90%.

[0035] In this application, the tetrafluoroether azole active ingredient, which is component (a) in the bactericidal composition, has a weight percentage of 1-20%, for example 1%, 2%, 5%, 8%, 10%, 12.2%, 14.5%, 15%, 17.8%, 19% or 20%, preferably 5-15%.

[0036] In this application, the active ingredient of benomyl, which is component (b) in the bactericidal composition, has a weight percentage of 1-50%, for example 1%, 2%, 3.2%, 5%, 10%, 15.5%, 19.8%, 25%, 28.8%, 30%, 35%, 38.1%, 40%, 44%, 48%, 49% or 50%, preferably 10-30%.

[0037] In this application, the [2,4,6-tris(1-phenylethyl)phenyl] ether of formula I, which is polymerized from ethylene oxide and propylene oxide, as component (c), has a weight percentage of 2-15%, for example 2%, 3%, 3.6%, 5%, 7%, 9%, 10%, 12%, 12.9%, 14%, or 15%, preferably 3-10%. When the percentage of the formulation is less than 2%, the compatibility problem cannot be completely solved due to the low dosage. On the other hand, when the percentage of the formulation is greater than 15%, there is a risk that it is difficult to formulate.

[0038] In this application, the optional functional surfactant, as component (d), in the bactericidal composition is 1-20% by weight, for example 1%, 2%, 4%, 5.5%, 7%, 9%, 10%, 12.3%, 13%, 14%, 15%, 16%, 17%, 18%, 19% or 20%, preferably 3-15%.

[0039] In this application, the diluent, which is component (e) in the bactericidal composition, has a weight percentage of 15-90%, for example 15%, 20%, 25%, 28%, 30%, 35%, 40%, 45.5%, 50%, 53.6%, 58.9%, 62%, 65%, 68%, 70%, 74%, 75%, 78%, 80%, 82.2%, 85.4%, 87%, 89%, or 90%, preferably 30-70%.

[0040] More preferably, the bactericidal composition described in this application comprises the following components in weight percentage:

[0041] (a) 5-15% by weight of tetrafluoroetherazole active liquid at room temperature;

[0042] (b) 10-30% by weight of benomyl active ingredient at room temperature in solid form;

[0043] (c) [2,4,6-tris(1-phenylethyl)phenyl] ether of formula I, polymerized from ethylene oxide and propylene oxide, in a weight percentage of 5-12%;

[0044] (d) Optional functional surfactants in weight percentages of 3-15%; and

[0045] (e) Diluent with a weight percentage of 30-70%.

[0046] On the other hand, this application also provides a method for preparing the aforementioned bactericidal composition, which includes the following steps:

[0047] Step I: Mix components (a), (b), (c), (d), and (e) in any order under stirring conditions until homogeneous;

[0048] Step II: Crush or grind the mixture from Step I to a mixture with an average particle size D50 ≤ 4 μm; and

[0049] Step III: Formulate the mixture from Step II into dosage forms.

[0050] The preparation method provided in this application involves mixing tetrafluoroether azole active ingredient, benomyl active ingredient, [2,4,6-tris(1-phenylethyl)phenyl] ether polymerized from ethylene oxide and propylene oxide of formula I, other functional surfactants, and diluents together, followed by grinding or pulverizing to obtain a semi-finished mother liquor or mother powder. Then, the mother liquor or mother powder is formulated according to the final dosage form requirements.

[0051] Suitable formulations include suspensions, emulsions, microcapsule suspensions-suspensions, large granules, water-dispersible granules, emulsions, wettable powders, and dry suspensions. Preferred formulations are suspensions, emulsions, water-dispersible granules, and emulsions. This preparation method is simple and easy to operate. Furthermore, this formulation method can obtain a fungicidal composition of tetraflufenicol and benomyl with uniform content, solving the compatibility problem of long-term storage between liquid tetraflufenicol and solid benomyl, reducing or avoiding the aggregation and sedimentation of oil droplets after dilution with water, thereby reducing the risk of clogging sprayers or nozzles.

[0052] Preferably, the average particle size D50 of the mixture after pulverization or grinding in step II is ≤4μm, for example 0.5μm, 0.85μm, 1μm, 1.2μm, 1.5μm, 1.8μm, 2.1μm, 2.5μm, 2.9μm, 3μm, 3.2μm, 3.5μm, 3.85μm or 4μm, with the preferred D50 being between 1.2μm and 2.5μm.

[0053] Preferably, the dosage formization in step III involves processing the mixture from step II into a liquid dosage form such as a suspension, emulsion, or microcapsule suspension-suspension, or into a solid dosage form such as large granules, water-dispersible granules, emulsions, or wettable powders.

[0054] The formulation of the fungicide composition containing tetraflufenicol and benomyl prepared according to this application solves the storage compatibility problem of tetraflufenicol and benomyl, and in particular solves the problem of mutual aggregation and sedimentation between the oil droplet form of tetraflufenicol and the particulate form of benomyl during the dilution process after storage, thereby reducing the risk of clogging the sprayer.

[0055] Technically, this application overcomes the incompatibility between liquid tetrafluoroetherazole and solid benomyl in the composition and the problem of mutual aggregation and sedimentation when the composition is diluted with water by adding [2,4,6-tris(1-phenylethyl)phenyl] ether, which is polymerized from ethylene oxide and propylene oxide with the general formula C30H30O(C3H6O)m(C2H4O)n(I), thus avoiding the risk of spray liquid clogging the sprayer. Detailed Implementation

[0056] To facilitate understanding of this application, the following embodiments are provided. Those skilled in the art should understand that these embodiments are merely illustrative and should not be construed as limiting the scope of this application.

[0057] Experiment 1: Tetrafluthrin + Benomyl 10% + 20% suspension emulsion

[0058] Table 1: Compositions

[0059]

[0060]

[0061] Preparation method of Example 1: Vegetable oil, ethoxylated castor oil, and tetrafluoroethylene ether were stirred evenly, and then mixed with benomyl, [2,4,6-tris(1-phenylethyl)phenyl] ether polymerized from ethylene oxide and propylene oxide, propylene glycol, methacrylic acid copolymer, etc., into deionized water. After stirring evenly, the mixture was wet-milled in a sand mill until the average particle size was about 2.5 μm. A certain amount of defoamer and xanthan gum were added to the resulting milling liquid, and the mixture was stirred evenly to obtain a suspension containing 10% + 20% tetrafluoroethylene ether and benomyl. (Comparative Examples 1-5 were prepared according to the preparation method of Example 1, keeping the processing parameters basically the same).

[0062] Before storing the samples from Example 1 and Comparative Examples 1-5 at room temperature and after 12 months of storage, the appearance changes of each sample were observed. The changes in the diluted solution were also observed after each sample was diluted 100 times with water, shaken well, and allowed to stand for 10 minutes. The experimental results are shown in Table 2.

[0063] Table 2

[0064]

[0065]

[0066] Application Example 1: Spray Liquid Pressure Test: Samples from Examples 1 and Comparative Examples 1-5, after storage, were diluted with water to obtain 20 L of spray liquid, with a dosage of 500 g. The 20 L diluted liquid was circulated under the action of a pump and passed through a fine sieve. The pressure of the liquid passing through the fine sieve was recorded every hour, and a sample of the liquid passing through the fine sieve was taken every hour. The total content (ppm) of tetrafluoromethane and benomyl in the diluted liquid was analyzed by liquid chromatography. An increase in pressure gauge readings indicated that the nozzle and fine sieve were clogged. The results are shown in Table 3.

[0067] Table 3

[0068]

[0069]

[0070] Experiment 2: Tetrafluthazole + Benomyl 5% + 50% water-dispersible granules

[0071] Table 4: Compositions

[0072]

[0073]

[0074] Preparation method of Example 2: Tetrafluoroetherazole, benomyl, calcium dodecylbenzenesulfonate, [2,4,6-tris(1-phenylethyl)phenyl] ether polymerized from ethylene oxide and propylene oxide, lignin sulfonate, solid defoamer, and calcined kaolin were mixed evenly, and then air-jet milled to obtain a master powder with an average particle size of less than 3 μm. Water was added to the master powder for kneading and granulation, followed by granulation and drying to obtain a 5% + 50% water-dispersible granule of tetrafluoroetherazole + benomyl. (Comparative Examples 6-10 were prepared according to the preparation method of Example 2, maintaining basically the same processing parameters.)

[0075] Before storing the samples from Example 2 and Comparative Examples 6-10 at room temperature and after 12 months of storage, the appearance changes of each sample were observed. The changes in the diluted solution were also observed after each sample was diluted 100 times with water, shaken well, and allowed to stand for 10 minutes. The experimental results are shown in Table 5.

[0076] Table 5:

[0077]

[0078]

[0079] Application Example 2: Spray Liquid Pressure Test: Samples from Examples 2 and Comparative Examples 6-10 were diluted with water to obtain 20 L of spray liquid, with a dosage of 500 g. The 20 L diluted liquid was circulated under the action of a pump and passed through a fine sieve. The pressure of the liquid passing through the fine sieve was recorded every hour, and a sample of the liquid passing through the sieve was taken every hour. The total content (ppm) of tetrafluoromethane and benomyl in the diluted liquid was analyzed by liquid chromatography. An increase in pressure gauge readings indicated that the nozzle and fine sieve were clogged. The results are shown in Table 6.

[0080] Table 6

[0081]

[0082]

[0083] Example 3

[0084] Tetrafluthrin + Benomyl 8% + 30% Emulsifiable Concentrate

[0085]

[0086] Example 3 Preparation method: Tetrafluoroetherazole, methyl oleate, and ethoxylated vegetable oil were mixed evenly, and then mixed evenly with benomyl, [2,4,6-tris(1-phenylethyl)phenyl] ether polymerized from ethylene oxide and propylene oxide, lignin sulfonate, defoamer, and diatomaceous earth. The mixture was then pulverized by an air jet mill to obtain a master powder with an average particle size of less than 3 μm. The master powder was mixed with water, kneaded and granulated, sized, and dried to obtain a tetrafluoroetherazole + benomyl 8% + 30% emulsion granule.

[0087] Example 4

[0088] Tetrafluthrin + Benzophenone 6% + 24% Dry Suspension

[0089]

[0090] Example 4 Preparation Method: Tetrafluoroetherazole, benomyl, organosilicon defoamer, [2,4,6-tris(1-phenylethyl)phenyl] ether polymerized from ethylene oxide and propylene oxide, naphthalene sulfonate formaldehyde condensate, polycarboxylate dispersant, fumed silica, lactose, and an appropriate amount of water were mixed to obtain a mixture with a solid content of about 50%. The mixture was then wet-milled using a sand mill to obtain a suspension with an average particle size of 2.0 μm. The suspension was then transferred to a spray tower for spray granulation and dried to obtain a 6% + 24% dry suspension of tetrafluoroetherazole and benomyl.

[0091] Before storing the samples from Examples 3-4 at room temperature and after 12 months of storage, the appearance changes of each sample were observed, as well as the changes in the diluted solution after diluting each sample 100 times with water, shaking well, and letting it stand for 10 minutes. The experimental results are shown in Table 7.

[0092] Table 7

[0093]

[0094] Application Example 3: Spray Liquid Pressure Test: The samples stored in Examples 3 and 4 were diluted with water to obtain 20 L of spray liquid, with a dosage of 500 g. The 20 L diluted liquid was circulated under the action of a pump and passed through a fine sieve. The pressure of the liquid passing through the fine sieve was recorded every hour, and a sample of the liquid passing through the fine sieve was taken every hour. The total content (ppm) of tetrafluoromethylenetetramine and benomyl in the diluted liquid was analyzed by liquid chromatography. An increase in pressure gauge readings indicated that the nozzle and fine sieve were clogged. The results are shown in Table 8.

[0095] Table 8

[0096]

[0097] The compositions listed in the embodiments of this application can effectively overcome the compatibility issues between liquid tetraflufenicol and solid benomyl. By adding a specific structure or amount of [2,4,6-tris(1-phenylethyl)phenyl] ether polymerized from ethylene oxide and propylene oxide, the room temperature storage compatibility of tetraflufenicol and benomyl is effectively improved. At the same time, the prepared formulation has good dilution stability. Even at high dilution ratios, tetraflufenicol and benomyl still have good compatibility, and the diluted solution or spray solution will not flocculate or settle, which has good commercialization value.

Claims

1. A fungicidal composition containing tetraflufenicol and benomyl, characterized in that, The bactericidal composition comprises the following components in weight percentage: (a) Tetrafluoroetherazole active ingredient in liquid form at room temperature, with a weight percentage of 1-20%; (b) 1-50% by weight of benomyl active ingredient in solid form at room temperature; (c) 2-15% by weight of [2,4,6-tris(1-phenylethyl)phenyl] ether polymerized from ethylene oxide and propylene oxide, as shown in Formula I, with the general formula: C 30 H 30 O(C3H6O) m (C2H4O) n (I) Where 10≤m≤50, 5≤n≤25; (d) Functional additives at a weight percentage of 1-20%; and (e) A diluent comprising 15-90% by weight; said diluent being water or a solid filler; The functional additive is any one or a combination of at least two of the following: defoamer, dispersant, wetting agent, emulsifier, antioxidant, pH adjuster, thickener, antifreeze agent or disintegrant; The formulation of the bactericidal composition is a suspension emulsion, a water-dispersible granule, an emulsion, or a dry suspension.

2. The bactericidal composition according to claim 1, characterized in that, The liquid contains 5-15% tetrafluoroether azole active ingredient by weight at room temperature.

3. The bactericidal composition according to claim 1, characterized in that, The weight percentage of the solid benomyl active ingredient at room temperature is 10-30%.

4. The bactericidal composition according to claim 1, characterized in that, The weight percentage of [2,4,6-tris(1-phenylethyl)phenyl] ether polymerized from ethylene oxide and propylene oxide as shown in Formula I is 3-10%.

5. The bactericidal composition according to claim 1, characterized in that, The functional additives comprise 3-15% by weight.

6. The bactericidal composition according to claim 1, characterized in that, The diluent has a weight percentage of 30-70%.

7. A stable water spray liquid, characterized in that, The water spray contains a bactericidal composition containing tetrafluoromethylene and benomyl as described in any one of claims 1-6 and water.

8. A method for preparing a stable water spray solution as described in claim 7, characterized in that, The preparation method comprises: mixing water and a bactericidal composition containing tetrafluoromethylene ether and benomyl as described in any one of claims 1-6 to obtain the stable water spray solution.

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