A seed treatment agent containing nicotine compounds and its preparation method

Abstract

The present invention belongs to the technical field of pesticides, and relates to a seed treatment agent containing nicotinoid compounds as active components and its application technology. The seed treatment agent of the present invention contains an effective ingredient, and the active ingredient is an effective ingredient A; or, effective ingredient A and effective ingredient B; wherein, effective ingredient A is a nicotinoid compound, and effective ingredient B is an insecticide and / or a fungicide. The effective ingredient A is imidacloprid, thiamethoxam or clothianidin; the effective ingredient B insecticide is tetrachlorantraniliprole or a compound shown in formula 1 (compound X); the seed treatment agent of the present invention has significant advantages in the application performance of formulation technology due to the application of special materials and special process conditions, and its safety is excellent, especially under adverse low temperature environment conditions, the germination potential and germination rate of seeds after coating are significantly improved.

Description

Technical Field

[0001] The invention belongs to the technical field of pesticides and relates to a seed treating agent containing nicotine compounds as active components and an application technology thereof. Background Art

[0002] Nicotinic compounds are the main force in seed treatment agents. At present, the nicotine compounds used in seed treatment agents in China are mainly imidacloprid, thiamethoxam, clothianidin or dimethomorph, among which imidacloprid, thiamethoxam and clothianidin are mainly used as active ingredients. The mechanism of action of nicotine insecticides is that they selectively bind to acetylcholine receptors as nicotinic acetylcholine receptor agonists, compete with insect acetylcholine, block the normal conduction of the central nervous system, and then cause insect paralysis and death. Due to this mechanism of action, in the application of seed treatment agents, especially when high-content preparations (greater than or equal to 30% of the overall preparation content) are used, there will be obvious problems of corn seed germination inhibition. Faced with the trend that domestic genetically modified crops may be liberalized, the development and design content of this type of compound needs to be improved. In this regard, the content of such pesticides used in seed treatment agents will not be too low in actual application. Especially for the application of seed treatment agents, it will involve multiple pesticides or be used in combination with different fungicides to achieve the effect of one coating and multiple prevention and control. Then the content of the preparation after compounding will be higher. Therefore, the safety issues of this type of high-content preparation coating will be more prominent.

[0003] Seed treatment agents are used for seed coating, especially for insect and disease prevention when seeds are at their weakest. Therefore, when seeds are coated with high levels of agents, safety issues will be the most difficult problem. Especially in the actual field application process, different climatic conditions, such as low temperature and high humidity, will significantly inhibit seed germination potential and germination rate.

[0004] In the existing technology, the solution to coating safety in the industry is basically to add growth regulators, hormones and other substances. For example, many documents mention that adding plant growth regulators and hormones to seed treatment agents can significantly improve crop growth, increase germination potential and germination rate, increase root weight, and accelerate seedling and root growth under adverse conditions. This type of solution is used frequently and for a long time, and it is relatively easy for seeds to develop resistance. Summary of the invention

[0005] The object of the present invention is to provide a seed treatment agent containing nicotine compounds and its preparation method.

[0006] To achieve the above object, the technical solution adopted by the present invention is:

[0007] A seed treatment agent containing nicotine compounds, the seed treatment agent contains an active ingredient, the active ingredient is active ingredient A; or, active ingredient A and active ingredient B; wherein active ingredient A is a nicotine compound, and active ingredient B is an insecticide and / or a fungicide.

[0008] The active ingredient A is imidacloprid, thiamethoxam or clothianidin; the active ingredient B insecticide is tetrachlorantraniliprole or a compound shown in formula 1 (compound X);

[0009]

[0010] R1 is selected from Cl; R2 is selected from Br; R3 is selected from Br or Cl; R4 is selected from H;

[0011] The active ingredient B fungicide is metalaxyl-M, fludioxonil, pyraclostrobin, trichlorfonazole or cyanooxystrobin.

[0012] When the active ingredients are active ingredient A and active ingredient B, the weight ratio of active ingredient A to active ingredient B is 1:100 to 100:1.

[0013] When the active ingredients are active ingredient A and active ingredient B, the weight ratio of active ingredient A to active ingredient B is 1:50 to 50:1.

[0014] The preparation is a seed treatment suspension, which is a mixture of the active ingredient according to claim 1, a carrier and at least one auxiliary agent; wherein the weight percentage of the active ingredient in the preparation is 30% to 70%.

[0015] The auxiliary agent includes one or more of anionic surfactants and nonionic surfactants.

[0016] The anionic surfactant is one or more of sulfonates, sulfates, carboxylates, phosphates, succinates, and lignin sulfonates;

[0017] The nonionic surfactant is one or more of fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ether, acid alcohol ester and its polyoxyethylene ether, fatty amide and its polyoxyethylene ether, castor oil polyoxyethylene ether, alkanolamide and its polyoxyethylene ether, block copolymer, sodium alkylnaphthalene sulfonate fatty alcohol polyoxyethylene ether, sorbitan fatty acid ester polyoxyethylene ether, styrene maleic anhydride copolymer, phenethylphenol polyoxyethylene polyoxypropylene ether and formaldehyde condensate.

[0018] The auxiliary agent in the preparation further includes monoterpenoid substances, wherein the added amount of the monoterpenoid substances accounts for 1-10% of the preparation; the monoterpenoid substances are menthol or cantharidin,

[0019] The monoterpenoid substance and the anionic surfactant, wherein the ratio of the monoterpenoid substance to the anionic surfactant is 1:10-10:1, preferably 1:5-5:1.

[0020] A method for preparing a seed treatment agent containing nicotine compounds comprises the following steps: shearing and stirring an effective ingredient, a carrier, and required auxiliary agents except monoterpenoid substances until the particle size reaches within 10 microns, introducing the mixture into a sand mill for sand grinding until the particle size reaches within 5 microns, pouring out the feed liquid, adding monoterpenoid substances, and stirring evenly to obtain the seed treatment agent.

[0021] The advantages of the present invention are:

[0022] The seed treatment agent of the present invention is a binary or ternary mixture of nicotine compounds or the compounded mixture of nicotine compounds and diamide insecticides (tetrachlorantraniliprole, compound X) and / or fungicides (metalaxyl-M, fludioxonil, pyraclostrobin, trichlorfonazole, cyanothiocarb), which is suitable for insecticidal and fungicidal effects of high value-added crops such as corn, wheat, soybeans, rice, peanuts, cotton, tobacco, potatoes and vegetables. It can be especially applied to the application of genetically modified crops; the obtained seed treatment agent has significant advantages in the application performance of formulation technology due to the application of special materials and special process conditions, and its safety is excellent, especially under adverse low temperature environment conditions, the germination potential and germination rate of the seeds after coating are significantly improved.

[0023] In addition, adding monoterpenoid substances to the seed treatment agent of the present invention can provide seed protection in adverse environments and resist low temperature environments. At the same time, by confirming the addition process, the safety problem of coated seeds can be solved. No related reports have been found. DETAILED DESCRIPTION

[0024] The following specific examples are used to further illustrate the present invention in detail, but the present invention is by no means limited to these examples, and methods well known to those skilled in the art are all included in the scope of the present invention.

[0025] In the present invention, nicotine compounds are mixed with diamide insecticides (tetrachlorantraniliprole, compound X) or fungicides such as metalaxyl-M, fludioxonil, pyraclostrobin, trichlorfonazole and cyanothiocarb, and applied to seed treatment agents for seed coating to prevent and control seed-borne diseases and soil-borne diseases transmitted in the soil, that is, pests and diseases are controlled starting from crop seeds; at the same time, the safety technical problem of seeds coated with high-content agents under low temperature conditions can be effectively solved.

[0026] The nicotine compounds involved in the present invention can also be compounded with fungicides such as difenoconazole, metconazole, prothioconazole, pyraclostrobin, triadimefon, tebuconazole, carbendazim, thiram, myclobutanil, pyraclostrobin, thiophanate-methyl, and insecticides such as dinotefuran and carbosulfan to obtain seed treatment agents. It is speculated that the technical solution of the present invention can also play a positive role in improving seed safety when the nicotine compounds are compounded with the above-mentioned compositions into seed treatment agents.

[0027] The percentages and parts in the following examples are all by weight. The active component compound X is prepared according to the prior art (content 93-98%) and added in a 100% dosage. The proportions of each component are weight percentages, and the other raw materials are commercially available. The structure of the compound X used is shown in Table 1. The remaining active components and the auxiliary agents used are all purchased from the market.

[0028]

[0029] Table 1 Structure of Compound X

[0030] Compound <![CDATA[R1]]> <![CDATA[R2]]> <![CDATA[R3]]> <![CDATA[R4]]> X-1 Cl Br Br H X-2 Cl Br Cl H

[0031] Preparation formula example

[0032] Example 1 Group

[0033] Example 1-1 46% Imidacloprid seed treatment suspension

[0034] According to the formula requirements, imidacloprid 46%, SK24 2%, AMS303 3%, YUS-FS3000 1%, RED 1313%, magnesium aluminum silicate 0.5%, white carbon black 0.5%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill and sanded until the particle size is within 5 microns, and a 46% imidacloprid seed treatment suspension can be obtained.

[0035] Example 1-2 46% Imidacloprid seed treatment suspension

[0036] According to the formula requirements, imidacloprid 46%, menthol 1%, AMS303 3%, YUS-FS3000 1%, RED 1313%, magnesium aluminum silicate 0.5%, white carbon black 0.5%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill and sanded until the particle size is within 5 microns, and a 46% imidacloprid seed treatment suspension can be obtained.

[0037] Example 1-3 46% Imidacloprid seed treatment suspension

[0038] According to the formula requirements, imidacloprid 46%, SK24 2%, menthol 1%, AMS303 3%, YUS-FS3000 1%, RED 131 3%, magnesium aluminum silicate 0.5%, white carbon black 0.5%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill and sanded until the particle size is within 5 microns, so as to obtain 46% imidacloprid seed treatment suspension. Example 1-4 46% imidacloprid seed treatment suspension

[0039] According to the formula requirements, imidacloprid 46%, SK24 2%, AMS303 3%, YUS-FS3000 1%, RED 1313%, magnesium aluminum silicate 0.5%, white carbon black 0.5%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns, the liquid is poured out, menthol 1% is added, and stirred evenly to obtain 46% imidacloprid seed treatment suspension.

[0040] Example 2 Group

[0041] Example 2-1 60% Imidacloprid seed treatment suspension

[0042] According to the formula requirements, imidacloprid 60%, Atlox 5%, AMS303 3%, DB08 1%, RED 131 3%, magnesium aluminum silicate 0.5%, white carbon black 0.5%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns to obtain 60% imidacloprid seed treatment suspension.

[0043] Example 2-2 60% Imidacloprid seed treatment suspension

[0044] According to the formula requirements, imidacloprid 60%, menthol 1%, AMS303 3%, DB08 1%, RED 131 3%, magnesium aluminum silicate 0.5%, white carbon black 0.5%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns to obtain 60% imidacloprid seed treatment suspension.

[0045] Example 2-3 60% Imidacloprid Seed Treatment Suspension Concentrate

[0046] According to the formula requirements, imidacloprid 60%, Atlox 5%, menthol 1%, AMS303 3%, DB08 1%, RED131 3%, magnesium aluminum silicate 0.5%, white carbon black 0.5%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns to obtain 60% imidacloprid seed treatment suspension.

[0047] Example 2-4 60% Imidacloprid seed treatment suspension

[0048] According to the formula requirements, imidacloprid 60%, Atlox 5%, AMS303 3%, DB08 1%, RED 131 3%, magnesium aluminum silicate 0.5%, white carbon black 0.5%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns, the feed liquid is poured out, menthol 1% is added, and stirred evenly to obtain a 60% imidacloprid seed treatment suspension.

[0049] Example 3 Group

[0050] Example 3-1 30% Thiamethoxam seed treatment suspension

[0051] According to the formula requirements, thiamethoxam 30%, SK24 5%, DB08 3%, SP-SC3 1%, RED 131 6%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill and sanded until the particle size is within 5 microns, and a 30% thiamethoxam seed treatment suspension can be obtained.

[0052] Example 3-2 30% Thiamethoxam seed treatment suspension

[0053] According to the formula requirements, thiamethoxam 30%, menthol 1%, DB08 3%, SP-SC3 1%, RED 131 6%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns to obtain a 30% thiamethoxam seed treatment suspension.

[0054] Example 3-3 30% Thiamethoxam seed treatment suspension

[0055] According to the formula requirements, thiamethoxam 30%, SK24 5%, menthol 1%, DB08 3%, SP-SC3 1%, RED131 6%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns to obtain a 30% thiamethoxam seed treatment suspension.

[0056] Example 3-4 30% Thiamethoxam seed treatment suspension

[0057] According to the formula requirements, thiamethoxam 30%, SK24 5%, DB08 3%, SP-SC3 1%, RED 131 6%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns, the feed liquid is poured out, menthol 1% is added, and stirred evenly to obtain a 30% thiamethoxam seed treatment suspension.

[0058] Example 4 Group

[0059] Example 4-1 46% Thiamethoxam seed treatment suspension

[0060] According to the formula requirements, thiamethoxam 46%, SK24 3%, DB08 3%, SP-2700 1%, RED 131 6%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns to obtain 46% thiamethoxam seed treatment suspension.

[0061] Example 4-2 46% Thiamethoxam seed treatment suspension

[0062] According to the formula requirements, 46% thiamethoxam, 3% menthol, 3% DB08, 1% SP-2700, 6% RED 131, 0.2% magnesium aluminum silicate, 0.2% white carbon black, and water are added to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns, so as to obtain 46% thiamethoxam seed treatment suspension.

[0063] Example 4-3 46% Thiamethoxam seed treatment suspension

[0064] According to the formula requirements, 46% thiamethoxam, 3% SK24, 3% menthol, 3% DB08, 1% SP-2700, 6% RED131, 0.2% magnesium aluminum silicate, 0.2% white carbon black, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill and sanded until the particle size is within 5 microns, and a 46% thiamethoxam seed treatment suspension can be obtained.

[0065] Example 4-4 46% Thiamethoxam seed treatment suspension

[0066] According to the formula requirements, thiamethoxam 46%, SK24 3%, DB08 3%, SP-2700 1%, RED 131 6%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns, the feed liquid is poured out, menthol 3% is added, and stirred evenly to obtain 46% thiamethoxam seed treatment suspension.

[0067] Example 5 Group

[0068] Example 5-1 48% Clothianidin seed treatment suspension

[0069] According to the formula requirements, clothianidin 48%, SK24 1%, DB08 2%, Atlox4917 1%, RED 131 6%, magnesium aluminum silicate 0.1%, white carbon black 0.1%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns to obtain 48% clothianidin seed treatment suspension.

[0070] Example 5-2 48% Clothianidin seed treatment suspension

[0071] According to the formula requirements, 48% of clothianidin, 4% of menthol, 2% of DB08, 1% of Atlox4917, 6% of RED 131, 0.1% of magnesium aluminum silicate, 0.1% of white carbon black, and water is added to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns, so as to obtain 48% clothianidin seed treatment suspension.

[0072] Example 5-3 48% Clothianidin seed treatment suspension

[0073] According to the formula requirements, 48% clothianidin, 1% SK24, 4% menthol, 2% DB08, 1% Atlox4917, 6% RED131, 0.1% magnesium aluminum silicate, 0.1% white carbon black, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill to sand grind until the particle size is within 5 microns, so as to obtain 48% clothianidin seed treatment suspension. Example 5-4 48% clothianidin seed treatment suspension

[0074] According to the formula requirements, clothianidin 48%, SK24 1%, DB08 2%, Atlox4917 1%, RED 131 6%, magnesium aluminum silicate 0.1%, white carbon black 0.1%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns, the feed liquid is poured out, menthol 4% is added, and stirred evenly to obtain 48% clothianidin seed treatment suspension.

[0075] Example 6 Group

[0076] Example 6-1 50% tetrachlorantraniliprole + thiamethoxam seed treatment suspension (40+10)

[0077] According to the formula requirements, 40% of tetrachlorvinamide, 10% of thiamethoxam, 2% of SP27001, 3% of AMS303, 2% of SK-34SC, 6% of RED 131, 0.2% of magnesium aluminum silicate, and 0.2% of white carbon are added with water to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns to obtain a 50% tetrachlorvinamide thiamethoxam seed treatment suspension.

[0078] Example 6-2 50% tetrachlorantraniliprole + thiamethoxam seed treatment suspension (40+10)

[0079] According to the formula requirements, 40% of tetrachlorvinamide, 10% of thiamethoxam, 6% of menthol, 3% of AMS303, 2% of SK-34SC, 6% of RED 131, 0.2% of magnesium aluminum silicate, and 0.2% of white carbon are added with water to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns to obtain a 50% tetrachlorvinamide thiamethoxam seed treatment suspension.

[0080] Example 6-3 50% tetrachlorantraniliprole + thiamethoxam seed treatment suspension (40+10)

[0081] According to the formula requirements, 40% of tetrachlorvinamide, 10% of thiamethoxam, 2% of SP27001, 6% of menthol, 33% of AMS30, 2% of SK-34SC, 6% of RED 131, 0.2% of magnesium aluminum silicate, and 0.2% of white carbon are added with water to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns to obtain a 50% tetrachlorvinamide thiamethoxam seed treatment suspension.

[0082] Example 6-4 50% tetrachlorantraniliprole + thiamethoxam seed treatment suspension (40+10)

[0083] According to the formula requirements, 40% of tetrachlorvinamide, 10% of thiamethoxam, 2% of SP27001, 3% of AMS303, 2% of SK-34SC, 6% of RED 131, 0.2% of magnesium aluminum silicate, and 0.2% of white carbon are added with water to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns. The feed liquid is poured out, 6% of menthol is added, and stirred evenly to obtain a 50% tetrachlorvinamide and thiamethoxam seed treatment suspension.

[0084] Example 7 Group

[0085] Example 7-1 50% tetrachlorantraniliprole + clothianidin seed treatment suspension (40+10)

[0086] According to the formula requirements, 40% of tetrachlorvinphos, 10% of clothianidin, 1% of Atlox 4913, 3% of SPSC3275, 1% of SK-24N, 4% of RED 131, 0.2% of magnesium aluminum silicate, and 0.2% of white carbon are added, and water is added to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns, so as to obtain a 50% tetrachlorvinphos clothianidin seed treatment suspension.

[0087] Example 7-2 50% tetrachlorantraniliprole + clothianidin seed treatment suspension (40+10)

[0088] According to the formula requirements, 40% of tetrachlorvinphos, 10% of clothianidin, 2% of menthol, 3% of SPSC3275, 1% of SK-24N, 4% of RED 131, 0.2% of magnesium aluminum silicate, 0.2% of white carbon black, and water is added to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns, so as to obtain 50% tetrachlorvinphos clothianidin seed treatment suspension.

[0089] Example 7-3 50% tetrachlorantraniliprole + clothianidin seed treatment suspension (40+10)

[0090] According to the formula requirements, 40% of tetrachlorvinphos, 10% of clothianidin, 1% of Atlox 4913, 2% of menthol, 3% of SPSC3275, 1% of SK-24N, 4% of RED 131, 0.2% of magnesium aluminum silicate, 0.2% of white carbon black, and water is added to 100%, and the above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns to obtain a 50% tetrachlorvinphos clothianidin seed treatment suspension.

[0091] Example 7-4 50% tetrachlorantraniliprole + clothianidin seed treatment suspension (40+10)

[0092] According to the formula requirements, 40% of tetrachlorvinamide, 10% of clothianidin, 1% of Atlox 4913, 3% of SPSC3275, 1% of SK-24N, 4% of RED 131, 0.2% of magnesium aluminum silicate, 0.2% of white carbon black, and water is added to 100%, and the above substances are sheared and stirred until the particle size is within 10 microns. The mixture is introduced into a sand mill and sanded until the particle size is within 5 microns. The feed liquid is poured out, 2% of menthol is added, and stirred evenly to obtain a 50% tetrachlorvinamide clothianidin seed treatment suspension.

[0093] Example 8 Group

[0094] Example 8-1 50% Compound X-1 + Thiamethoxam Seed Treatment Suspension Concentrate (40+10)

[0095] According to the formula requirements, 40% of compound X-1, 10% of thiamethoxam, 1% of SP27001, 4% of AMS303, 3% of SK-34SC, 6% of RED 131, 0.2% of magnesium aluminum silicate, and 0.2% of white carbon are added with water to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns, thereby obtaining a 50% compound X thiamethoxam seed treatment suspension.

[0096] Example 8-2 50% Compound X-1 + Thiamethoxam Seed Treatment Suspension Concentrate (40+10)

[0097] According to the formula requirements, 40% of compound X-1, 10% of thiamethoxam, 7% of menthol, 4% of AMS303, 3% of SK-34SC, 6% of RED 131, 0.2% of magnesium aluminum silicate, and 0.2% of white carbon are added with water to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns, so as to obtain a 50% compound X-1 thiamethoxam seed treatment suspension.

[0098] Example 8-3 50% Compound X-1 + Thiamethoxam Seed Treatment Suspension Concentrate (40+10)

[0099] According to the formula requirements, 40% of compound X-1, 10% of thiamethoxam, 1% of SP27001, 7% of menthol, 34% of AMS30, 3% of SK-34SC, 6% of RED 131, 0.2% of magnesium aluminum silicate, and 0.2% of white carbon are added with water to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns, so as to obtain a 50% compound X-1 thiamethoxam seed treatment suspension.

[0100] Example 8-4 50% Compound X-1 + Thiamethoxam Seed Treatment Suspension Concentrate (40+10)

[0101] According to the formula requirements, 40% of compound X, 10% of thiamethoxam, 1% of SP27001, 4% of AMS303, 3% of SK-34SC, 6% of RED 131, 0.2% of magnesium aluminum silicate, and 0.2% of white carbon are prepared with water to 100%. The above substances are sheared and stirred until the particle size is within 10 microns. The mixture is introduced into a sand mill and sanded until the particle size is within 5 microns. The feed liquid is poured out, 7% of menthol is added, and the mixture is stirred evenly to obtain a 50% compound X-1 thiamethoxam seed treatment suspension.

[0102] Example 9 Group

[0103] Example 9-1 50% Compound X-2 Clothianidin seed treatment suspension (40+10)

[0104] According to the formula requirements, compound X-240%, clothianidin 10%, Atlox 4913 2%, SPSC3275 1%, SK-24N 3%, RED 131 4%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding, and the sand grinding is performed until the particle size is within 5 microns, so as to obtain a 50% compound X-2 clothianidin seed treatment suspension.

[0105] Example 9-2 50% Compound X-2 + Clothianidin Seed Treatment Suspension Concentrate (40+10)

[0106] According to the formula requirements, 40% of compound X-2, 10% of clothianidin, 3% of menthol, 1% of SPSC3275, 3% of SK-24N, 4% of RED 131, 0.2% of magnesium aluminum silicate, 0.2% of white carbon black, and water are added to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns, so as to obtain a 50% compound X-2 clothianidin seed treatment suspension.

[0107] Example 9-3 50% Compound X-2 + Clothianidin Seed Treatment Suspension Concentrate (40+10)

[0108] According to the formula requirements, 40% of compound X-2, 10% of clothianidin, 2% of Atlox 4913, 3% of menthol, 1% of SPSC3275, 3% of SK-24N, 4% of RED 131, 0.2% of magnesium aluminum silicate, and 0.2% of white carbon are added with water to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns, so as to obtain a 50% compound X-2 + clothianidin seed treatment suspension.

[0109] Example 9-4 50% Compound X-2 + Clothianidin Seed Treatment Suspension Concentrate (40+10)

[0110] According to the formula requirements, 40% of compound X-2, 10% of clothianidin, 2% of Atlox 4913, 1% of SPSC3275, 3% of SK-24N, 4% of RED 131, 0.2% of magnesium aluminum silicate, and 0.2% of white carbon are added, and water is added to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns. The feed liquid is poured out, 3% of menthol is added, and stirred evenly to obtain a 50% compound X-2 clothianidin seed treatment suspension.

[0111] Example 10 Group

[0112] Example 10-1 25% Thiamethoxam + Metalaxyl-M suspension seed coating agent (21.5 + 3.5)

[0113] According to the formula requirements, thiamethoxam 21.5%, metalaxyl-M 3.5%, SK24 1%, AMS303 2%, YUS-FS3000 3%, RED 131 4%, magnesium aluminum silicate 0.5%, white carbon 0.5%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns to obtain a 25% thiamethoxam-metalaxyl suspended seed coating agent.

[0114] Example 10-2 25% Thiamethoxam + Metalaxyl-M suspension seed coating agent (21.5 + 3.5)

[0115] According to the formula requirements, thiamethoxam 21.5%, metalaxyl-M 3.5%, menthol 2%, AMS303 2%, YUS-FS3000 3%, RED 131 3%, magnesium aluminum silicate 0.5%, white carbon 0.5%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns to obtain a 25% thiamethoxam-metalaxyl suspended seed coating agent.

[0116] Example 10-3 25% Thiamethoxam + Metalaxyl-M suspension seed coating agent (21.5 + 3.5)

[0117] According to the formula requirements, thiamethoxam 21.5%, metalaxyl-M 3.5%, SK24 1%, menthol 2%, AMS3032%, YUS-FS3000 3%, RED 131 3%, magnesium aluminum silicate 0.5%, white carbon 0.5%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns to obtain 25% thiamethoxam-metalaxyl suspended seed coating agent.

[0118] Example 10-4 25% Thiamethoxam + Metalaxyl-M suspension seed coating agent (21.5 + 3.5)

[0119] According to the formula requirements, thiamethoxam 21.5%, metalaxyl-M 3.5%, SK24 1%, AMS303 2%, YUS-FS3000 3%, RED 131 3%, magnesium aluminum silicate 0.5%, white carbon black 0.5%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns, the liquid is poured out, menthol 2% is added, and stirred evenly to obtain a 25% thiamethoxam-metalaxyl suspended seed coating agent.

[0120] Example 11 Group

[0121] Example 11-1 50% Thiamethoxam + Fludioxonil Seed Treatment Suspension Concentrate (47.5 + 2.5)

[0122] According to the formula requirements, 47.5% of thiamethoxam, 2.5% of fludioxonil, 1% of Atlox, 2% of AMS303, 3% of DB08, 4% of RED 131, 0.5% of magnesium aluminum silicate, 0.5% of white carbon black, and water is added to 100%, and the above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding, and the sand grinding is carried out until the particle size is within 5 microns, so as to obtain a 50% thiamethoxam fludioxonil seed treatment suspension.

[0123] Example 11-2 50% Thiamethoxam + Fludioxonil Seed Treatment Suspension Concentrate (47.5 + 2.5)

[0124] According to the formula requirements, 47.5% of thiamethoxam, 2.5% of fludioxonil, 8% of menthol, 2% of AMS303, 3% of DB08, 4% of RED 131, 0.5% of magnesium aluminum silicate, 0.5% of white carbon black, and water is added to 100%, and the above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding, and the sand grinding is carried out until the particle size is within 5 microns, so as to obtain a 50% thiamethoxam fludioxonil seed treatment suspension.

[0125] Example 11-3 50% Thiamethoxam + Fludioxonil Seed Treatment Suspension Concentrate (47.5 + 2.5)

[0126] According to the formula requirements, 47.5% of thiamethoxam, 2.5% of fludioxonil, 1% of Atlox, 8% of menthol, 2% of AMS303, 3% of DB08, 4% of RED 131, 0.5% of magnesium aluminum silicate, and 0.5% of white carbon are added with water to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns, so as to obtain a 50% thiamethoxam fludioxonil seed treatment suspension.

[0127] Example 11-4 50% Thiamethoxam + Fludioxonil Seed Treatment Suspension Concentrate (47.5 + 2.5)

[0128] According to the formula requirements, 47.5% of thiamethoxam, 2.5% of fludioxonil, 1% of Atlox, 2% of AMS303, 3% of DB08, 4% of RED 131, 0.5% of magnesium aluminum silicate, and 0.5% of white carbon are added, and water is added to 100%. The above substances are sheared and stirred until the particle size is within 10 microns, and the mixture is introduced into a sand mill for sand grinding until the particle size is within 5 microns. The feed liquid is poured out, 8% of menthol is added, and stirred evenly to obtain a 50% thiamethoxam fludioxonil seed treatment suspension.

[0129] Example 12 Group

[0130] Example 12-1 50% Thiamethoxam + Pyraclostrobin Seed Treatment Suspension Concentrate (32+18)

[0131] According to the formula requirements, thiamethoxam 32%, pyraclostrobin 18%, SK24 3%, DB08 2%, SP-SC3 1%, RED 131 6%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the sand grinding is carried out until the particle size is within 5 microns, so as to obtain a 50% thiamethoxam pyraclostrobin seed treatment suspension.

[0132] Example 12-2 50% Thiamethoxam + Pyraclostrobin Seed Treatment Suspension Concentrate (32+18)

[0133] According to the formula requirements, thiamethoxam 32%, pyraclostrobin 18%, menthol 3%, DB08 2%, SP-SC3 1%, RED 131 6%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the sand grinding is carried out until the particle size is within 5 microns, so as to obtain a 50% thiamethoxam pyraclostrobin seed treatment suspension.

[0134] Example 12-3 50% Thiamethoxam + Pyraclostrobin Seed Treatment Suspension Concentrate (32+18)

[0135] According to the formula requirements, thiamethoxam 32%, pyraclostrobin 18%, SK24 3%, menthol 3%, DB08 2%, SP-SC3 1%, RED 131 6%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the sand grinding is carried out until the particle size is within 5 microns, so as to obtain a 50% thiamethoxam pyraclostrobin seed treatment suspension.

[0136] Example 12-4 50% Thiamethoxam + Pyraclostrobin Seed Treatment Suspension Concentrate (32+18)

[0137] According to the formula requirements, thiamethoxam 32%, pyraclostrobin 18%, SK24 3%, DB08 2%, SP-SC3 1%, RED 131 6%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns, the feed liquid is poured out, menthol 3% is added, and stirred evenly to obtain a 50% thiamethoxam pyraclostrobin seed treatment suspension.

[0138] Example 13

[0139] Example 13-1 50% Thiamethoxam + Trichlorfon Suspension Concentrate for Seed Treatment (22+28)

[0140] According to the formula requirements, 22% thiamethoxam, 28% trichlorfonazole, 2% SK24, 2% DB08, 2% SP-2700, 5% RED131, 0.2% magnesium aluminum silicate, 0.2% white carbon black, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill and sanded until the particle size is within 5 microns, and a 50% thiamethoxam trichlorfonazole seed treatment suspension can be obtained. Example 13-2 50% thiamethoxam + trichlorfonazole seed treatment suspension (22+28)

[0141] According to the formula requirements, thiamethoxam 22%, trichlorfon 28%, menthol 10%, DB08 2%, SP-2700 2%, RED 131 5%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the sand grinding is carried out until the particle size is within 5 microns, so as to obtain a 50% thiamethoxam trichlorfon seed treatment suspension.

[0142] Example 13-3 50% Thiamethoxam + Trichlorfon Suspension Concentrate for Seed Treatment (22+28)

[0143] According to the formula requirements, thiamethoxam 22%, trichlorfon 28%, SK24 2%, menthol 10%, DB08 2%, SP-2700 2%, RED 131 5%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the sand grinding is carried out until the particle size is within 5 microns, so as to obtain a 50% thiamethoxam trichlorfon seed treatment suspension.

[0144] Example 13-4 50% Thiamethoxam + Trichlorfon Suspension Concentrate for Seed Treatment (22+28)

[0145] According to the formula requirements, thiamethoxam 22%, trichlorfon 28%, SK24 2%, DB08 2%, SP-2700 2%, RED131 5%, magnesium aluminum silicate 0.2%, white carbon black 0.2%, water is added to 100%, the above substances are sheared and stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns, the feed liquid is poured out, menthol 10% is added, and stirred evenly to obtain a 50% thiamethoxam trichlorfon seed treatment suspension.

[0146] Seed safety test

[0147] The seed treatment agent in the above embodiment is used to coat corn seeds, wherein the coating method ratio is based on the actual registered application, and the specific coating ratio in the present invention adopts a larger dosage, which is higher than the normal coating ratio conditions. If the safety problem after coating at a large dose is solved, then the technical problem will be effectively solved when a small dose is actually used.

[0148] Example 1 Group

[0149] The different 46% imidacloprid seed treatment suspensions obtained in Example 1 were coated at a ratio of 1:100, i.e., 10 g of the preparation and 1000 g of corn were weighed, placed in a culture dish for mixing and coating, shaken evenly, poured out, left to dry, and then subjected to safety testing.

[0150] Example 2 Group

[0151] The different 60% imidacloprid seed treatment suspensions obtained in Example 2 were coated at a ratio of 1:150, i.e., 6.67 g of the preparation and 1000 g of corn were weighed, placed in a petri dish for mixing and coating, shaken evenly, poured out, left to dry, and then subjected to safety testing.

[0152] Example 3 Group

[0153] The different 30% thiamethoxam seed treatment suspensions obtained in Example 3 were coated at a ratio of 1:75, i.e., 13.33 g of the preparation and 1000 g of corn were weighed, placed in a culture dish for mixing and coating, shaken evenly, poured out, left to dry, and then safety tests were performed.

[0154] Example 4 Group

[0155] The different 46% thiamethoxam seed treatment suspensions obtained in Example 4 were coated at a ratio of 1:120, i.e. 8.33 g of the preparation and 1000 g of corn were weighed, placed in a petri dish for mixing and coating, shaken evenly, poured out, left to dry, and then safety tested.

[0156] Example 5 Group

[0157] The different 48% clothianidin seed treatment suspensions obtained in Example 5 were coated at a ratio of 1:120, i.e. 8.33 g of the preparation and 1000 g of corn were weighed, placed in a petri dish for mixing and coating, shaken evenly, poured out, left to dry, and then subjected to safety testing.

[0158] Example 6 Group

[0159] The different 50% tetrachlorantraniliprole + thiamethoxam seed treatment suspensions obtained in Example 6 were coated at a ratio of 1:25, i.e. 40 g of the preparation and 1000 g of corn were weighed, placed in a culture dish for mixed coating, shaken evenly, poured out, left to dry, and then safety measurements were performed.

[0160] Example 7 Group

[0161] The different 50% tetrachlorantraniliprole + clothianidin seed treatment suspensions obtained in Example 7 were coated at a ratio of 1:25, i.e. 40 g of the preparation and 1000 g of corn were weighed, placed in a culture dish for mixed coating, shaken evenly, poured out, left to dry, and then safety measurements were performed.

[0162] Example 8 Group

[0163] The different 50% compound X-1 + thiamethoxam seed treatment suspensions obtained in Example 8 were coated at a ratio of 1:25, i.e. 40 g of the preparation and 1000 g of corn were weighed, placed in a culture dish for mixed coating, shaken evenly, poured out, left to dry, and then subjected to safety testing.

[0164] Example 9 Group

[0165] The different 50% compound X-1 + clothianidin seed treatment suspensions obtained in Example 9 were coated at a ratio of 1:25, i.e. 40 g of the preparation and 1000 g of corn were weighed, placed in a culture dish for mixing and coating, shaken evenly, poured out, left to dry, and then subjected to safety testing.

[0166] Example 10 Group

[0167] The different 25% thiamethoxam + metalaxyl-M seed treatment suspensions obtained in Example 10 were coated at a ratio of 1:100, i.e., 10 g of the preparation and 1000 g of corn were weighed, placed in a culture dish for mixed coating, shaken evenly, poured out, left to dry, and then subjected to safety testing.

[0168] Example 11 Group

[0169] The different 50% thiamethoxam + fludioxonil seed treatment suspensions obtained in Example 11 were coated at a ratio of 1:120, i.e., 8.33 g of the preparation and 1000 g of corn were weighed, placed in a culture dish for mixing and coating, shaken evenly, poured out, left to dry, and then subjected to safety testing.

[0170] Example 12 Group

[0171] The different 50% thiamethoxam + pyraclostrobin seed treatment suspensions obtained in Example 12 were coated at a ratio of 1:75, i.e., 13.33 g of the preparation and 1000 g of corn were weighed, placed in a culture dish for mixed coating, shaken evenly, poured out, left to dry, and then safety measurements were performed.

[0172] Example 13 Group

[0173] The different 50% thiamethoxam + pyraclostrobin seed treatment suspensions obtained in Example 13 were coated at a ratio of 1:52, i.e., 19.23 g of the preparation and 1000 g of corn were weighed, placed in a culture dish for mixed coating, shaken evenly, poured out, left to dry, and then safety measurements were performed.

[0174] The above experiments verify the objective fact that the theory exists, that is, after the seeds are coated with the agent, as the coating concentration increases, the amount of effective ingredients attached to the seed surface increases, and the safety problem becomes more and more obvious. If a safe coating scheme can be achieved under higher concentrations, then safety can be guaranteed under actual lower concentration conditions.

[0175] The safety of the two seed treatment agents obtained above was completed by the present invention using GB / T3543.4-1995 Crop Seed Inspection Procedure - Germination Test. Germination refers to the appearance and growth of seedlings in the laboratory to a certain stage, and the main structure of the seedlings indicates whether they can further grow into normal plants under suitable conditions in the field. The germination potential refers to the germination trend, which is observed on the 4th day according to relevant standards, and the germination rate is the percentage of normal seedlings grown under the specified conditions and time to the number of seeds for inspection.

[0176] Each set of experiments was repeated four times, and the average value was taken as the final result, with 100 seeds in each group.

[0177] The experiment uses sand as the germination bed. The sand particles are uniform in size, with a diameter of 0.05-0.80mm, and the seeds are non-toxic and sterile. Wash and sterilize at high temperature before use. The sand bed adopts the sand-in-sand method, that is, the seeds are sown on a layer of flat wet sand, and then covered with 10-20mm thick loose sand according to the seed size.

[0178] The germination equipment is a germination box: with light, temperature control range 10-40℃;

[0179] According to the corn germination conditions specified in the standard, the minimum temperature is 20°C. The selection of this minimum temperature is based on the minimum temperature for corn seed germination inspection specified in the national standard GB / T 3543.4-1995 "Germination Test for Crop Seed Inspection Procedures". This temperature is also closer to the actual field application temperature. The reason is that the technology of this application is mainly used in the actual industrialization process, not in the research work of low temperature extreme conditions under harsh conditions. Therefore, the germination potential and germination rate are measured at this temperature both during the day and at night to meet the real needs of production applications.

[0180] Germination potential is the percentage of seedlings that emerged 4 days after planting to the total number;

[0181] The germination rate is the percentage of seedlings that emerged 7 days after planting.

[0182] Among them, blank refers to blank seeds not coated with any agent, not a control group; safety data can be found in Table 2.

[0183] Table 2 Safety data of embodiments and comparative examples

[0184]

[0185]

[0186]

[0187] As can be seen from Table 2, the germination potential and germination rate of the preparation samples without adding monoterpenoid menthol after coating seeds are lower than those of the blank control. The reason for this is that, as mentioned above, the young seeds will be inhibited to a certain extent after being wrapped by the active components of the pesticide, especially the germination potential will be affected. In the -2, -3, and -4 controls of each group of embodiments, monoterpenoid menthol was added, and the germination potential and germination rate were alleviated, and were significantly higher than the blank control. When menthol was compounded with carboxylate / lignin, the safety of the seeds, i.e., the germination potential and germination rate, were further improved, such as -3 was superior to -2 in each group. For the addition method of menthol, after adopting the addition method of -4, the safety of the coated seeds was increased to a certain extent on the basis of it. Therefore, it can be seen that the present invention effectively solves the problem of safety affected by nicotine-containing preparations after coating seeds under low temperature conditions. Through the implementation of this technical solution, the germination potential and germination rate of seeds can be significantly improved, so that the safety of crops can be guaranteed. At present, in the industry, the application of seed treatment agents, the germination rate after coating is compared with the blank, at least equivalent to it. When the germination rate after coating is lower than the blank, it means that there are certain risks in the treatment, and this risk is fatal in actual application. The present invention examines the problem of whether the seeds can germinate normally after being coated with a large amount of pesticides under adverse conditions, that is, under low temperature conditions. This is also the most concerned issue in the industry, whether it is formulation research and development personnel or farmers. Once encountering extreme adverse conditions after sowing, such as no germination, the germination rate is reduced to less than the blank, which will cause huge losses to the user. However, under low temperature adverse conditions, the present invention, under the premise that the germination potential and germination rate of the seeds after coating are compared with the blank treatment, have a certain decrease, for the seed treatment agent of nicotinoid compounds, the safety is significantly improved under the technical scheme.

[0188] At the same time, it is further explained that the safety test adopted in the aforementioned experiment of the present invention was carried out with a relatively stringent drug species ratio. Therefore, further supplementary experiments were conducted to expand the coating ratio to illustrate that the safety will be better after the expansion of the drug species ratio, that is, the reduction of the amount of drug covering the coated seeds. Therefore, it is also confirmed that the drug species ratio adopted in the aforementioned experiment was carried out under relatively stringent conditions.

[0189] (1) 46% imidacloprid seed treatment suspension was coated at a ratio of 1:100, i.e., 10 g of the preparation and 1000 g of corn were weighed, placed in a petri dish, mixed and coated, shaken evenly, poured out, left to dry, and then safety tested.

[0190] (2) 46% imidacloprid seed treatment suspension was coated at a ratio of 1:200, i.e., 10 g of the preparation and 2000 g of corn were weighed, placed in a petri dish, mixed and coated, shaken evenly, poured out, left to dry, and then tested for safety.

[0191] (3) 50% compound X-1 + thiamethoxam seed treatment suspension was coated at a ratio of 1:25, i.e. 40 g of the preparation and 1000 g of corn were weighed, placed in a petri dish, mixed and coated, shaken evenly, poured out, left to dry, and then safety tested.

[0192] (4) 50% Compound X-1 + Thiamethoxam seed treatment suspension was coated at a ratio of 1:50, i.e. 40 g of the preparation and 2000 g of corn were weighed, placed in a petri dish, mixed and coated, shaken evenly, poured out, left to dry, and then safety tested.

[0193] See Table 3 for safety data from additional experiments.

[0194] Table 3 Safety data of examples and comparative examples

[0195]

Claims

1. A seed treatment agent containing nicotine compounds, characterized in that: The seed treatment agent is a seed treatment suspension, comprising an active ingredient, a carrier and at least one adjuvant; wherein the weight percentage of the active ingredient in the preparation is 30% to 70%; The active ingredient is active ingredient A; or, active ingredient A and active ingredient B; wherein active ingredient A is imidacloprid, thiamethoxam or clothianidin; active ingredient B is an insecticide or a fungicide; The active ingredient B insecticide is tetrachlorantraniliprole or a compound shown in formula 1; Formula 1 R1 is selected from Cl; R2 is selected from Br; R3 is selected from Br or Cl; R4 is selected from H; The active ingredient B fungicide is metalaxyl-M, fludioxonil, pyraclostrobin or trichlorfonazole; The adjuvant includes monoterpenoid substances, and the amount of monoterpenoid substances added accounts for 1-10% of the preparation; the monoterpenoid substance is menthol; When the active ingredients are active ingredient A and active ingredient B, the weight ratio of active ingredient A to active ingredient B is 1:50 to 50:1; The auxiliary agent also includes one or more of anionic surfactants and nonionic surfactants; The anionic surfactant is one or more of sulfonates, sulfates, carboxylates, phosphates, succinates, and lignin sulfonates; The nonionic surfactant is one or more of fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ether, acid alcohol ester and its polyoxyethylene ether, fatty amide and its polyoxyethylene ether, castor oil polyoxyethylene ether, alkanolamide and its polyoxyethylene ether, block copolymer, sodium alkylnaphthalene sulfonate fatty alcohol polyoxyethylene ether, sorbitan fatty acid ester polyoxyethylene ether, styrene maleic anhydride copolymer, phenethylphenol polyoxyethylene polyoxypropylene ether and formaldehyde condensate.

2. The seed treatment agent containing nicotinoid compounds according to claim 1, characterized in that: The auxiliary agent is an anionic surfactant, wherein the ratio of the monoterpenoid substance to the anionic surfactant is 1:10-10:

1.

3. A method for preparing a seed treatment agent containing nicotine compounds according to claim 1, characterized in that: The active ingredient, carrier, and required auxiliary agents except monoterpenoids are shear-stirred until the particle size is within 10 microns, the mixture is introduced into a sand mill for sand grinding, and the particle size is within 5 microns, the liquid is poured out, the monoterpenoids are added, and the mixture is stirred evenly.

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