A preparation process of compound chlorhexidine dusting powder and its production line

Abstract

The invention discloses a preparation process of compound chlorhexidine dusting powder, comprising: accurately weighing zinc oxide, sublimated sulfur, borneol, menthol and talcum powder respectively, and performing weighing verification; mixing zinc oxide, sublimated sulfur, borneol, menthol and part of talcum powder, crushing, and then washing the crusher with part of talcum powder after crushing, combining the materials crushed twice to obtain crushed mixed powder; mixing essence and part of talcum powder, sieving, and obtaining essence mixed powder; premixing the prescribed amount of chlorhexidine hydrochloride with part of talcum powder, sieving, and obtaining chlorhexidine hydrochloride mixed powder; putting the crushed mixed powder, essence mixed powder, chlorhexidine hydrochloride mixed powder and part of talcum powder into a mixer for mixing. Further, after linseed oil is atomized, sodium alginate is used for embedding, and the surface layer of the capsule wall is solidified, and the obtained microcapsule powder is put into a mixer for full mixing to improve the wound healing rate. The invention also provides a process production line for preparing compound chlorhexidine dusting powder.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceutical processing, in particular to a preparation process of compound chlorhexidine dusting powder and a process production line thereof. Background Art

[0002] Compound chlorhexidine powder, indications are used for various types of prickly heat, prickly heat poison, intertriginous tinea pedis, intertriginous rash, and can also be used for skin itching caused by mosquito bites. This product is a compound preparation, containing 5 mg of chlorhexidine hydrochloride, 22 mg of zinc oxide, 2 mg of sublimated sulfur, 4 mg of borneol, and 4 mg of menthol per gram. This powder can be used to keep the skin dry, prevent the generation of prickly heat and inhibit the regeneration of prickly heat. In addition, although the existing large amount of talcum powder for powdering keeps the skin dry well, the surface of some wounds with exudate is too dry, making the wound unable to heal quickly; generally, a certain moist environment can accelerate the migration speed of epidermal cells, promote the release of growth factors, and stimulate cell proliferation, while an overly dry environment affects the rapid healing of wounds. On the other hand, the compound chlorhexidine powder of the existing process is mainly made by sieving and mixing, and the process is simple, but the cleaning cleanliness of each equipment during the process operation is not good, and the process operation is not meticulous enough, resulting in a large loss of raw materials. Summary of the invention

[0003] The invention provides a preparation process of compound chlorhexidine dusting powder and a process production line thereof.

[0004] In order to achieve the above object, the present invention adopts the following technical scheme:

[0005] In a first aspect, the present invention provides a preparation process of a compound chlorhexidine dusting powder, wherein the dusting raw materials include chlorhexidine hydrochloride, zinc oxide, sublimated sulfur, borneol, menthol, essence, and talcum powder; the preparation process comprises the following steps:

[0006] S1. Accurately weigh zinc oxide, sublimated sulfur, borneol, menthol and talcum powder respectively, and perform weighing verification;

[0007] S2, zinc oxide, sublimed sulfur, borneol, menthol and part of talcum powder are mixed, crushed with a universal grinder, and then the grinder is rinsed with part of talcum powder after crushing, and the materials crushed twice are combined to obtain a crushed mixed powder;

[0008] S3, mix the essence and part of the talcum powder, and sieve through an oscillating sieve to obtain a flavor mixed powder;

[0009] S4, premixing the prescribed amount of chlorhexidine hydrochloride with part of talcum powder, and sieving with an oscillating sieve to obtain a chlorhexidine hydrochloride mixed powder;

[0010] S5. Put the crushed mixed powder, the flavor mixed powder, the chlorhexidine hydrochloride mixed powder and part of the talcum powder into a three-dimensional motion mixer for mixing to obtain the compound chlorhexidine mixed powder.

[0011] In a preferred technical solution, before step S1, it also includes: preparing purified water, and cleaning the equipment that contacts the powdering raw materials such as the universal grinder, the vibrating screen and the three-dimensional motion mixer, and then wiping or rinsing them with purified water; wherein the universal grinder and the screen in the vibrating screen are rinsed with purified water, and the discharge bag connecting the discharge port of the universal grinder and the feed port of the vibrating screen and the discharge bag of the three-dimensional motion mixer are rinsed with purified water.

[0012] In a preferred technical solution, the preparation process of the purified water is: using drinking water as raw water, after being treated by a quartz sand filter, an activated carbon filter, a softener, and a precision filter, the purified water is prepared by a two-stage reverse osmosis method.

[0013] In a preferred technical solution, step S5 specifically includes:

[0014] S5.1. Add the crushed mixed powder and the mixed powder of chlorhexidine hydrochloride into the three-dimensional motion mixer in sequence, turn on the three-dimensional motion mixer, and mix for 30 minutes for the first time;

[0015] S5.2, then add the flavor mixed powder and part of the talcum powder, and mix for a second time for 60 minutes;

[0016] S5.3, add some talcum powder and mix for a third time for 90 minutes;

[0017] The rotation speed of the three-dimensional motion mixer in the tertiary mixing was 29 Hz.

[0018] In a preferred technical solution, the powdering raw material further comprises linseed oil and sodium alginate; and the following steps are further included after step S5:

[0019] S6, atomizing the linseed oil and embedding it with sodium alginate, and then solidifying the surface layer of the capsule wall to obtain microcapsule powder;

[0020] S7, adding the microcapsule powder into a three-dimensional motion mixer and mixing with the compound chlorhexidine mixed powder, and mixing for the fourth time for 60 minutes.

[0021] In a preferred technical solution, step S6 specifically includes:

[0022] S6.1. Weigh out a prescribed amount of sodium alginate and dissolve it in water to prepare a sodium alginate solution;

[0023] S6.2, pumping linseed oil into the inlet of the venturi tube to perform decompression atomization to form micro-droplets; the sodium alginate solution is sucked from the suction port of the venturi tube and adsorbed on the surface of the micro-droplets to form embedded micro-droplets;

[0024] S6.3. Spray the embedded micro-droplets directly from the venturi tube into the reduced pressure atomized calcium salt aqueous solution. The atomized calcium salt solidifies the surface of the alginate droplets encapsulating the oil to obtain microcapsule powder; the particle size of the microcapsule powder is 100 to 500 μm.

[0025] In a preferred technical solution, the step S6.3 further includes:

[0026] S6.4. Cool the microcapsule powder particles obtained after spray drying using dry cold air, wherein the temperature of the dry cold air is 20° C. to 40° C.; and collect the microcapsule powder using a cyclone separator.

[0027] In a preferred technical solution, the raw materials include: 10-20 parts of chlorhexidine hydrochloride, 5-15 parts of zinc oxide, 3-10 parts of sublimated sulfur, 8-15 parts of borneol, 8-15 parts of menthol, 2000-3000 parts of talc, 40-60 parts of linseed oil and 50-100 parts of sodium alginate.

[0028] In another preferred technical solution, the step S7 further includes the following steps: after the total mixing is completed, the powder is placed in a screw filling and packaging machine for packaging into bottled semi-finished products of different specifications; during the packaging process, the filling amount is checked at least once an hour to determine whether it is qualified; and the qualified bottles are capped and packaged.

[0029] In a second aspect, the present invention provides a process production line for compound chlorhexidine powdering applied to the above-mentioned preparation process, comprising a universal pulverizer, a vibrating screen, a venturi tube, a cyclone separator, a three-dimensional motion mixer, a screw filling and packaging machine, and a prickly heat powder filling machine; the discharge port of the pulverizing equipment is connected to the feed port of the vibrating screen through a discharge bag, and the discharge port of the vibrating screen is connected to the feed port of the three-dimensional motion mixer through a discharge bag; the inlet of the cyclone separator is connected to the outlet of the venturi tube, and the discharge port of the cyclone separator is connected to the feed port of the three-dimensional motion mixer through a discharge bag. The cloth bag is connected to the feed hopper of the three-dimensional motion mixer; the discharge hopper of the three-dimensional motion mixer is connected to the feed hopper of the screw filling and packaging machine through a discharge cloth bag, and a drying device and a dryness detection device are arranged in the three-dimensional motion mixer; the feed hopper of the screw filling and packaging machine is connected to the feed hopper of the prickly heat powder filling machine through a discharge cloth bag; a transportation line of the packaging area is arranged below the filling port of the prickly heat powder filling machine, and a labeling machine and a coding machine are arranged on the side of the transportation line in sequence, and a heat shrink packaging machine and a strapping machine are arranged on the front side of the coding machine.

[0030] The preparation process of the compound chlorhexidine dusting powder of the present invention provides that each device is cleaned before use and then cleaned or wiped with purified water, thereby ensuring the cleanliness of the powder operation environment and preventing the equipment from being unclean and sticking to the powder or hanging the powder; in the process operation flow, each raw material is mixed in steps and times, so that the dusting mixing is more uniform and the material balance of input and output is improved.

[0031] In the second aspect, the compound chlorhexidine powder provided by the present invention is a microcapsule powder particle of linseed oil on the basis of existing ingredients. After the sodium alginate on the surface of the powder particles absorbs the wound exudate, the calcium ions in the dressing are exchanged with the sodium ions in the exudate, and a gel can be formed on the wound surface. The gel maintains an appropriate moist environment, prevents the wound surface from drying, reduces the inconvenience caused during removal, and enhances the healing rate of skin wounds, wherein the calcium ions also have a hemostatic effect. After the sodium alginate used as the wall material absorbs the liquid, the vegetable oil of the core material is released, and the linseed oil rich in α-linolenic acid plays an anti-inflammatory and antibacterial role, while further keeping the skin moist, so that the wound environment is maintained in a necessary moist environment, and promotes wound healing. The powder prepared by the process described in the present invention has better fluidity and adhesion, can absorb skin liquid, and promotes wound healing. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0033] Figure 1 It is a flow chart of an example of the preparation process of the compound chlorhexidine dusting powder according to an embodiment of the present invention;

[0034] Figure 2 It is a process flow chart of another example of the preparation of the compound chlorhexidine dusting powder according to an embodiment of the present invention;

[0035] Figure 3 The invention discloses a structural schematic diagram of a process production line for compound chlorhexidine powdering according to an embodiment of the invention. DETAILED DESCRIPTION

[0036] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0037] The present invention provides a production process of compound chlorhexidine dusting powder. Figure 1 As shown, the following steps are included:

[0038] S1. Accurately weigh zinc oxide, sublimated sulfur, borneol, menthol and talcum powder respectively, and perform weighing verification;

[0039] S2, zinc oxide, sublimed sulfur, borneol, menthol and part of talcum powder are mixed, crushed with a universal grinder, and then the grinder is rinsed with part of talcum powder after crushing, and the materials crushed twice are combined to obtain a crushed mixed powder;

[0040] S3, mix the essence and part of the talcum powder, and sieve through an oscillating sieve to obtain a flavor mixed powder;

[0041] S4, premixing the prescribed amount of chlorhexidine hydrochloride with part of talcum powder, and sieving with an oscillating sieve to obtain a chlorhexidine hydrochloride mixed powder;

[0042] S5, putting the crushed mixed powder, the flavor mixed powder, the chlorhexidine hydrochloride mixed powder and part of the talcum powder into a three-dimensional motion mixer for mixing to obtain the compound chlorhexidine mixed powder;

[0043] The step S5 specifically includes:

[0044] S5.1. Add the crushed mixed powder and the mixed powder of chlorhexidine hydrochloride into the three-dimensional motion mixer in sequence, turn on the three-dimensional motion mixer, and mix for 30 minutes for the first time;

[0045] S5.2, then add the flavor mixed powder and part of the talcum powder, and mix for a second time for 60 minutes;

[0046] S5.3, add some talcum powder and mix for a third time for 90 minutes;

[0047] The rotation speed of the three-dimensional motion mixer in the tertiary mixing was 29 Hz.

[0048] Before step S1, the method further includes: preparing purified water, and cleaning the equipment that contacts the powdering raw materials such as the universal grinder, the vibrating screen, and the three-dimensional motion mixer, and then wiping or rinsing them with purified water; wherein the universal grinder and the screen in the vibrating screen are rinsed with purified water, and the discharge bag connecting the discharge port of the universal grinder and the feed port of the vibrating screen and the discharge bag of the three-dimensional motion mixer are rinsed with pure water. The preparation process of the purified water is: using drinking water as raw water, after being treated by a quartz sand filter, an activated carbon filter, a softener, and a precision filter, it is prepared by a two-stage reverse osmosis method.

[0049] In the early stage of key equipment cleaning, sterilization and assembly process, the following equipment is included in the cleaning.

[0050] Cleaning and assembly of the universal grinder: In the operation room, use a cloth soaked in drinking water to clean the hopper, movable teeth, fixed teeth, and discharge port, and then wipe them with purified water. In the equipment cleaning room, brush the disassembled screen with drinking water, and then rinse it with purified water. Soak and scrub the discharge bag with drinking water, and then rinse it with purified water. Install the screen into the grinding chamber and fix it with screws; tie the discharge bag at the discharge port.

[0051] Cleaning and assembly of the vibrating screen: In the operation room, after disassembling the vibrating screen, take the screen, clamp, screen frame, seal ring, and discharge bag to the container cleaning room for cleaning. First rinse with drinking water, brush repeatedly, and then rinse with purified water. Scrub the remaining parts with drinking water in the operation room and then with purified water. Fix the cleaned screen, screen frame, and seal ring together with the clamp. Then assemble the discharge bag onto the vibrating screen.

[0052] Cleaning and assembly of the three-dimensional motion mixer: Clean the inside of the mixing barrel in the operation room: Pour drinking water into the mixing barrel and rotate for 10 minutes. Then wipe the inner wall of the mixing barrel with a rag, and then pour purified water to clean it. In the equipment cleaning room, soak the discharge cloth bag with drinking water and scrub it, and then rinse it with purified water.

[0053] Cleaning and assembly of screw filling and packaging machine: Cleaning: Disassemble according to the "Operation Procedure of Screw Filling and Packaging Machine", disassemble the hopper, agitator, etc. and put them into the equipment cleaning room. Scrub it with drinking water, and then rinse it with purified water for 2 minutes. In the operation room, first use a brush to clean the powder from the gap of the equipment, and then use compressed air and a rag soaked in drinking water to wipe the machine body and the non-detachable parts, and clean until the inside and outside of the filling and sealing machine and its parts are visually clean and bright, without any dirt residue. Assembly: Install the stirring spikes first, and then install the discharge hopper and receiving table respectively.

[0054] Cleaning and assembly of the prickly heat powder filling machine: Cleaning: Disassemble according to the "Prickly Heat Powder Filling Machine Operating Procedure", disassemble the hopper, agitator, etc. and put them into the equipment cleaning room. Scrub it with drinking water, and then rinse it with purified water for 2 minutes. In the operating room, first use a brush to clean the powder from the gaps in the equipment, and then use compressed air and a rag soaked in drinking water to wipe the body and the non-detachable parts, and clean until the inside and outside of the filling machine and its components are visually clean and bright, with no dirt residue. Assembly: Install the stirring spikes first, and then install the discharge hopper and receiving table respectively.

[0055] In the embodiment of scheme 1, the raw material prescription used is: 1.6 kg of chlorhexidine hydrochloride, 7.04 kg of zinc oxide, 0.64 kg of sublimated sulfur, 1.28 kg of borneol, 1.28 kg of menthol, 307.2 kg of talc, and 0.96 kg of essence; the specific steps are as follows:

[0056] S1. Weighing and preparation of raw and auxiliary materials

[0057] Accurately weigh the instructed amount of chlorhexidine hydrochloride, zinc oxide, sublimed sulfur, borneol, menthol, essence, and talcum powder. After the materials are weighed, hang the container identification card on the ingredient barrel. Collect the waste materials spilled during the weighing process, weigh and count them, and pour them into a waste plastic bag. The weighing review adopts the method of one person weighing and another person reviewing simultaneously, one person calibrating and another person supervising, one person weighing and another person supervising, reading, recording and signing separately, and the reviewer reviews the use of measuring instruments, readings, and weighing process results in real time.

[0058] S2. Crushing

[0059] Before and after production, check the integrity of the screen. Mix zinc oxide, sublimated sulfur, borneol, menthol and 40 kg of talcum powder and crush them with a universal crusher. The crusher screen is a 120-mesh stainless steel sieve. After the mixture is completely crushed, rinse the crusher with 40 kg of talcum powder and combine the materials crushed twice. Material balance calculation of the crushing process:

[0060]

[0061] Balance limit: 99.0%

[0062] S3, sieving:

[0063] Check the integrity of the sieve before and after sieving, mix the essence with 12.0 kg of talcum powder, and sieve it with an oscillating sieve with a 120-mesh sieve. Material balance calculation for the sieving process:

[0064]

[0065] Balance limit: 99.8%

[0066] S4. Manually premix the prescribed amount of chlorhexidine hydrochloride with 12.0 kg of talcum powder three times, and sieve through a 120-mesh sieve with an oscillating sieve for later use. Check the integrity of the sieve before and after sieving.

[0067] S5. Add the crushed mixed powder (zinc oxide, sublimated sulfur, borneol, menthol, talcum powder) and the mixed powder of chlorhexidine hydrochloride into the three-dimensional motion mixer in sequence, turn on the three-dimensional motion mixer, speed: 29 Hz, and mix for 30 minutes for the first time; secondly, add the sifted powder (flavor, talcum powder) and 85.0 kg of talcum powder, speed: 29 Hz, and mix for 60 minutes for the second time; then add the remaining talcum powder, speed: 29 Hz, and mix for 90 minutes for the third time.

[0068] Take a sample of the mixed powder, with a sample size of 100g, to test the properties, content, particle size, and loss on drying. After the mixed powder is collected, perform material balance calculation:

[0069]

[0070] Balance limit: 99.6%

[0071]

[0072] Yield: 99.1%.

[0073] In a second aspect, the raw materials of the compound chlorhexidine dusting powder of the present invention further include linseed oil and sodium alginate; Figure 2 As shown, the step S5 further includes the following steps:

[0074] S6, atomizing the linseed oil and embedding it with sodium alginate, and then solidifying the surface of the capsule wall to obtain microcapsule powder; specifically:

[0075] The weighed amount of sodium alginate is dissolved in water to prepare a sodium alginate solution; in the specific preparation process, 150-200 g of sodium alginate is dissolved in 5 L of water;

[0076] Linseed oil is pumped into the inlet of the venturi tube for decompression and atomization to form micro-droplets; sodium alginate solution is sucked from the suction port of the venturi tube and adsorbed on the surface of the micro-droplets to form embedded micro-droplets; wherein the venturi tube is a water jet venturi tube with a nozzle diameter of 3mm and a flow rate of 0.7m 3 / h;

[0077] The embedded micro droplets are directly sprayed from a venturi tube into a decompressed atomized calcium salt aqueous solution, and the atomized calcium salt solidifies the surface of the alginate droplets encapsulating the oil, and the solidification time is 2-4 minutes to obtain microcapsule powder; the size of the obtained microcapsule powder is 100-500 μm;

[0078] The microcapsule powder particles obtained after spray drying are cooled by dry cold air, wherein the temperature of the dry cold air is 20° C. to 40° C.; and the microcapsule powder particles are collected by a cyclone separator.

[0079] S7, adding the microcapsule powder into a three-dimensional motion mixer and mixing with the compound chlorhexidine mixed powder, mixing for the fourth time for 60 minutes, the rotation speed of the three-dimensional motion mixer is 29 Hz.

[0080] In the preparation process of the above-mentioned scheme 2, the compound chlorhexidine powder raw material can adopt a combination of the following examples.

[0081] Example 1: 1.3kg chlorhexidine hydrochloride, 0.5kg zinc oxide, 0.3kg sublimated sulfur, 0.8kg borneol, 0.8kg menthol, 210kg talcum powder, 4kg linseed oil, 5kg sodium alginate.

[0082] Example 2: 2kg of chlorhexidine hydrochloride, 1.5kg of zinc oxide, 1kg of sublimated sulfur, 1.5kg of borneol, 1.5kg of menthol, 299.2kg of talc, 6.2kg of linseed oil, and 10kg of sodium alginate.

[0083] Example 3: 1.6kg chlorhexidine hydrochloride, 7.04kg zinc oxide, 0.64kg sublimated sulfur, 1.28kg borneol, 1.28kg menthol, 307.2kg talcum powder, 0.96kg essence, 5.6kg linseed oil, 7.8kg sodium alginate.

[0084] The following is a test on the effect of the compound chlorhexidine powder product in the improved solution.

[0085] Test 1 This test example is used to illustrate the ability of the dusting powder prepared in the present invention to promote wound healing.

[0086] Sample preparation: The powder puff material prepared in Example 3 of Scheme 2 was taken as the experimental group, and the example of Scheme 1 was taken as the control group.

[0087] Selection of test subjects: 6-week-old SD rats (weight 200-230 g, female).

[0088] Test method: This experiment uses a rat back full-thickness skin damage model to evaluate the ability of powdering to promote wound healing. After the rats were anesthetized by intraperitoneal injection of chloral hydrate (0.3 mg / kg), the hair on their backs was shaved, and the rats were placed in a cage with multiple mosquitoes. After all the rats had redness and swelling on their backs after mosquito bites, they were taken out. After waiting for 12 hours, 10 rats with obvious redness, swelling and inflammation at the bite site, and blisters or pustules were screened and randomly divided into an experimental group and a control group, with 5 rats in each group. Each group was covered with two types of powder puff powders, and the powder puff powder was used three times a day. After the treatment, the mice in each group were placed in a cage for feeding, and the same amount of food and water were provided at a constant temperature. The wound images of 12 hours, 24 hours, 48 ​​hours, 72 hours, and 96 hours later were recorded with an ordinary camera. When taking pictures, the powder was cleaned up and the pictures were taken. The wound area was measured using Image J software, and the corresponding wound area ratio was calculated and plotted to analyze the wound healing. The wound area ratio is defined as the ratio of the wound area after treatment to the original wound area.

[0089] Test results: After 12 hours, the wounds in the experimental group had obvious scabs and began to heal gradually, while the wounds in the control group were dry and had no signs of scabs; after 24 hours, the wounds in both groups had obvious scabs and began to heal gradually, and the edges of the scabs in the experimental group began to fall off. At 48 hours, the wounds in the experimental group were completely closed, 1-2 days earlier than those in the control group.

[0090] The mechanism of accelerating wound healing may be: after sodium alginate on the surface of the powder particles absorbs wound exudate, calcium ions in the dressing are exchanged with sodium ions in the exudate, forming a gel on the wound surface. The gel maintains an appropriate moist environment, prevents the wound surface from drying, reduces the inconvenience caused by removal, and enhances the healing rate of skin wounds. When sodium alginate as a wall material absorbs liquid, the vegetable oil in the core material is released, and linseed oil plays an anti-inflammatory and antibacterial role, while further keeping the skin moist, so that the wound environment is maintained in the necessary moist environment, and promotes wound healing.

[0091] Test 2: Powdering Adhesion Effect Test

[0092] The compound chlorhexidine powder prepared in Example 1, Example 2 and Example 3 of Scheme 2 and the embodiment of Scheme 1 (as a control group) was sprinkled on the inner side of the upper arm area of ​​the same volunteer to conduct a skin adhesion test. Test process: 1g of the product of different embodiments was weighed and sprinkled on the upper arm area of ​​the volunteer by sprinkling, and the adhesion state and the adhesion state 6 hours after adhesion were observed.

[0093] After testing, the product in Example 1 had the largest amount of adhesion after sprinkling, and the control group had the smallest amount of adhesion. The corresponding amounts of adhesion of each product gradually decreased after 1 hour, 3 hours, and 6 hours after adhesion, and the adhesion was better than that of other groups. The products in Examples 1-3 and the control group did not produce allergic erythema at the skin sites where they were attached.

[0094] The present invention also provides a process production line for compound chlorhexidine powdering applied to the above-mentioned preparation process, such as Figure 3 As shown, it includes a universal grinder, a vibrating screen, a venturi tube, a cyclone separator, a three-dimensional motion mixer, a screw filling and packaging machine and a prickly heat powder filling machine; the discharge port of the grinder is connected to the feed port of the vibrating screen through a discharge bag, and the discharge port of the vibrating screen is connected to the feed port of the three-dimensional motion mixer through a discharge bag; the inlet of the cyclone separator is connected to the outlet of the venturi tube, and the discharge port of the cyclone separator is connected to the feed hopper of the three-dimensional motion mixer through a discharge bag; the discharge hopper of the three-dimensional motion mixer is connected to the feed hopper of the screw filling and packaging machine through a discharge bag, and the three-dimensional motion mixer is provided with a drying device and a dryness detection device.

[0095] A transport line of the packaging area is arranged below the filling port of the prickly heat powder filling machine, a labeling machine and a coding machine are arranged in sequence on the side of the transport line, and a heat shrink packaging machine and a strapping machine are arranged in front of the coding machine.

[0096] The production process and production process line of compound chlorhexidine powder provided in the embodiment of the present invention can realize the method embodiment provided above. For the specific function realization, please refer to the description in the method embodiment, which will not be repeated here.

[0097] Each embodiment in this specification is described in a progressive manner, and the same or similar parts between the embodiments can be referred to each other, and each embodiment focuses on the differences from other embodiments. In particular, for the device embodiment, since it is basically similar to the method embodiment, the description is relatively simple, and the relevant parts can be referred to the partial description of the method embodiment.

[0098] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed by the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A preparation process for compound chlorhexidine dusting powder, characterized in that, The powdering raw materials include chlorhexidine hydrochloride, zinc oxide, sublimated sulfur, borneol, menthol, essence, talcum powder, linseed oil and sodium alginate; the preparation process includes the following steps: S1. Accurately weigh zinc oxide, sublimated sulfur, borneol, menthol and talcum powder respectively, and perform weighing verification; S2, zinc oxide, sublimed sulfur, borneol, menthol and part of talcum powder are mixed, crushed with a universal grinder, and then the grinder is rinsed with part of talcum powder after crushing, and the materials crushed twice are combined to obtain a crushed mixed powder; S3, mix the essence and part of the talcum powder, and sieve through an oscillating sieve to obtain a flavor mixed powder; S4, premixing the prescribed amount of chlorhexidine hydrochloride with part of talcum powder, and sieving with an oscillating sieve to obtain a chlorhexidine hydrochloride mixed powder; S5, putting the crushed mixed powder, the flavor mixed powder, the chlorhexidine hydrochloride mixed powder and part of the talcum powder into a three-dimensional motion mixer for mixing to obtain the compound chlorhexidine mixed powder; S6, atomizing the linseed oil and embedding it with sodium alginate, and then solidifying the surface layer of the capsule wall to obtain microcapsule powder; S7, adding the microcapsule powder into a three-dimensional motion mixer and mixing with the compound chlorhexidine mixed powder, and mixing for the fourth time for 60 minutes.

2. the preparation technology of compound chlorhexidine dusting powder as claimed in claim 1, is characterized in that, Before step S1, the step further includes: preparing purified water, and wiping or rinsing the equipment that contacts the powdering raw materials, such as the universal grinder, the vibrating screen, and the three-dimensional motion mixer, with purified water after cleaning; wherein the universal grinder and the screen in the vibrating screen are rinsed with purified water, and the discharge bag connecting the discharge port of the universal grinder and the feed port of the vibrating screen and the discharge bag of the three-dimensional motion mixer are all 3. the preparation technology of compound chlorhexidine dusting powder as claimed in claim 2, is characterized in that, The preparation process of the purified water is as follows: drinking water is used as raw water, and after being treated by a quartz sand filter, an activated carbon filter, a softener, and a precision filter, the purified water is prepared by a two-stage reverse osmosis method.

4. The preparation technology of compound chlorhexidine dusting powder as claimed in claim 1, characterized in that, The step S5 specifically includes: S5.

1. Add the crushed mixed powder and the mixed powder of chlorhexidine hydrochloride into the three-dimensional motion mixer in sequence, turn on the three-dimensional motion mixer, and mix for 30 minutes for the first time; S5.2, then add the flavor mixed powder and part of the talcum powder, and mix for a second time for 60 minutes; S5.3, add some talcum powder and mix for a third time for 90 minutes; The rotation speed of the three-dimensional motion mixer in the tertiary mixing was 29 Hz.

5. The preparation technology of compound chlorhexidine dusting powder as claimed in claim 1, characterized in that, The step S6 specifically includes: S6.

1. Weigh out a prescribed amount of sodium alginate and dissolve it in water to prepare a sodium alginate solution; S6.2, pumping linseed oil into the inlet of the venturi tube to perform decompression atomization to form micro-droplets; the sodium alginate solution is sucked from the suction port of the venturi tube and adsorbed on the surface of the micro-droplets to form embedded micro-droplets; S6.

3. Spray the embedded micro-droplets directly from the venturi tube into the reduced pressure atomized calcium salt aqueous solution. The atomized calcium salt solidifies the surface of the alginate droplets encapsulating the oil to obtain microcapsule powder; the particle size of the microcapsule powder is 100 to 500 μm.

6. The preparation process of compound chlorhexidine dusting powder as claimed in claim 5, characterized in that, The step S6.3 further includes: S6.

4. Cool the microcapsule powder particles obtained after spray drying using dry cold air, wherein the temperature of the dry cold air is 20° C. to 40° C.; and collect the microcapsule powder using a cyclone separator.

7. The preparation process of the compound chlorhexidine dusting powder according to claim 1, characterized in that: The raw materials include: 10-20 parts of chlorhexidine hydrochloride, 5-15 parts of zinc oxide, 3-10 parts of sublimated sulfur, 8-15 parts of borneol, 8-15 parts of menthol, 2000-3000 parts of talc, 40-60 parts of linseed oil and 50-100 parts of sodium alginate.

8. The preparation process of compound chlorhexidine dusting powder as claimed in claim 1, characterized in that, After step S7, the method further includes: after the total mixing is completed, placing the medicine powder in a screw filling and packaging machine to be packaged into bottled semi-finished products of different specifications; during the packaging process, checking the filling amount at least once an hour to determine whether it is qualified; and packaging the bottles that have passed the inspection after fastening the caps.

9. A process production line for compound chlorhexidine powdering applied to the preparation process described in claim 1, characterized in that: It includes a universal pulverizer, a vibrating screen, a venturi tube, a cyclone separator, a three-dimensional motion mixer, a screw filling and packaging machine and a prickly heat powder filling machine; the discharge port of the pulverizing equipment is connected to the feed port of the vibrating screen through a discharge bag, and the discharge port of the vibrating screen is connected to the feed port of the three-dimensional motion mixer through a discharge bag; the inlet of the cyclone separator is connected to the outlet of the venturi tube, and the discharge port of the cyclone separator is connected to the feed hopper of the three-dimensional motion mixer through a discharge bag; The discharge hopper of the three-dimensional motion mixer is connected to the feed hopper of the screw filling and packaging machine through a discharge bag, and a drying device and a dryness detection device are arranged in the three-dimensional motion mixer; the feed hopper of the screw filling and packaging machine is connected to the feed hopper of the prickly heat powder filling machine through a discharge bag; a transportation line of the packaging area is arranged below the filling port of the prickly heat powder filling machine, and a labeling machine and a coding machine are arranged on the side of the transportation line in sequence, and a heat shrink packaging machine and a strapping machine are arranged on the front side of the coding machine.

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