A tissue-engineered collagen membrane surface texturing device

Abstract

This invention provides a tissue-engineered collagen membrane surface linting device, including a frame, a motor, a transmission device, and a linting roller assembly. The frame includes a motor mounting platform located at the rear of the frame, a linting roller assembly mounting platform extending vertically upward from the middle of the frame, a sample handling platform fixed to the top of the linting roller assembly mounting platform, and a sample recovery platform fixed to the bottom front side of the linting roller assembly mounting platform. The linting roller assembly includes a linting roller bracket, a first linting roller, and a second linting roller mounted parallel to each other within the mounting cavity of the linting roller bracket. A meshing gear is fixed to one end of the first linting roller extending beyond both axial ends of the linting roller bracket, and the other end meshes with a second meshing gear at the corresponding end of the second linting roller via the first meshing gear. The motor is connected to a transmission gear mounted on the linting roller assembly mounting platform and meshing with the meshing gear via a belt drive pulley. This linting device has dual functions of "thorning" and "hooking," has a simple structure, and is easy to promote.

Description

Technical Field

[0001] This invention belongs to the field of medical materials technology, specifically relating to a tissue-engineered collagen membrane surface texturing device. Background Technology

[0002] Tissue-engineered collagen membranes are extracellular matrix materials obtained from animal-derived tissues through antigen removal and decellularization. Common animal tissue sources include the pericardium, peritoneum, small intestinal mucosa, and cornea. Bio-engineered collagen membrane materials have been widely used in the medical field, such as oral collagen membranes in GBR surgery, hernia repair patches, and tissue patches in plastic surgery.

[0003] Currently, tissue-engineered collagen membranes obtained through tissue engineering techniques are popular in the market due to their natural origin, low immunogenicity, and biodegradability. However, their natural properties still present some challenges for clinical application. For example, in the case of oral collagen membranes used during GBR surgery, there is a clinical requirement for a smooth surface that can isolate soft tissue invasion and a rough surface suitable for bone tissue growth. However, due to the natural characteristics of biomaterials, the difference between the smooth and rough surfaces is minimal or nonexistent.

[0004] Tissue engineering technology involves deantigenating and decellularizing allogeneic tissues to obtain biocompatible, biodegradable extracellular matrix materials. The main allogeneic sources are common livestock such as cattle, pigs, sheep, and fish. Common tissue sources include the pericardium, peritoneum, small intestinal mucosa, and cornea. The pericardium and peritoneum have naturally multi-layered structures, resulting in significant differences in roughness between their two surfaces. The small intestinal mucosa is thinner, and the difference in roughness between its two surfaces is not significant. The cornea has a dense, multi-layered structure, including a cellular layer, an elastic layer, and a stroma layer, and exhibits no difference in roughness between its two surfaces. When animal tissues are processed using tissue engineering techniques, the difference in roughness between the two surfaces of the tissue decreases. For example, during the processing of the pericardium, the removal of surface fat and appendages causes the serosal layer and the rough surface layer of the pericardium to separate, resulting in a final product with no significant difference in roughness between its two surfaces, affecting its later clinical use.

[0005] Pile-forming machines are widely used in the textile industry. Due to the softness of textiles and the loose, orderly arrangement of their surface fibers, the core hooks of these machines are mostly made of nylon or metal, and their main function is to hook and stretch the surface fibers of textiles. However, tissue-engineered collagen membranes are thinner (usually less than 1mm), with a denser overall fiber structure than textiles, and their surface fibers are arranged in a disordered yet tightly packed manner. To achieve a pile-forming effect on tissue-engineered collagen membranes, the hooks of the pile-forming machine need to have a dual function of "piercing" and "hooking"—that is, the ability to pierce the surface of the collagen membrane, and the barbs on the hooks to hook the collagen fibers to achieve the pile-forming effect. Pile-forming machines used for textiles are unlikely to achieve the same pile-forming effect on the surface of tissue-engineered collagen membranes.

[0006] Patent CN113249912B discloses a napping roller mechanism for fleece fabric, comprising a roller body, adjusting plates fixed on both sides of the roller body, adjusting mechanisms on the adjusting plates, and a plurality of steel needle adjusting units mounted on the roller body. Each steel needle adjusting unit includes a plurality of rotatable steel needle mechanisms, and the adjusting mechanisms can drive the steel needle mechanisms to rotate to adapt to different steel needle densities and angles. The innovation of this invention lies in the fact that by setting a lateral moving adjusting rod, the steel needle mechanisms can be rotated to adapt to different adjustment angles. When the steel needles are adjusted to a horizontal position, the steel needle density can also be adjusted.

[0007] Patent CN113914047A describes a napping machine and a method for producing napped fabric using the same equipment. The machine includes a metal frame with a mounting roller rotatably mounted on it. The mounting roller is circumferentially spaced with several metal needle plates. Several scraping needles are spaced on one end face of each needle plate. The two ends of the mounting roller are rotatably mounted on the frame via metal bearings. The two ends of the needle plates abut against the inner rings of two bearings respectively.

[0008] The napping machines designed in the aforementioned patents are all used in the textile industry, and the hooks used only have the function of "hooking". As described in patent CN113249912B, the connection between the steel needle and the connecting rod is V-shaped and arc-shaped, which cannot realize the function of piercing tissue-engineered collagen membrane materials, and the steel needle cannot pierce the surface of the collagen membrane. Summary of the Invention

[0009] The purpose of this invention is to increase the surface roughness of tissue-engineered collagen membranes, thereby increasing their adhesion to irregular surfaces in clinical applications, facilitating operation and use, and meeting clinical needs.

[0010] To achieve the above objectives, the present invention provides a tissue-engineered collagen membrane surface texturing device, comprising a frame, a motor, a transmission device, and a texturing roller assembly;

[0011] The frame includes a motor mounting platform located at the rear of the frame, a napping roller assembly mounting platform extending vertically upward in the middle of the frame, a sample operation platform fixed to the top of the napping roller assembly mounting platform, and a sample recovery platform fixed to the bottom front of the napping roller assembly mounting platform.

[0012] The napping roller assembly includes a napping roller bracket, and a first napping roller and a second napping roller installed parallel to each other in the mounting cavity of the napping roller bracket;

[0013] A meshing gear is fixed at one end of the first napping roller that extends beyond the axial ends of the napping roller support, and the other end meshes with a second meshing gear at the corresponding end of the second napping roller through the first meshing gear;

[0014] The electric motor is connected to a transmission gear mounted on the brushing roller assembly mounting platform and meshing with the meshing gear via a belt drive pulley.

[0015] The beneficial effects of this invention are: the napping device has the dual functions of "thorning" and "hooking", has a simple structure, low cost, can be effectively industrialized, and is easy to promote. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of a tissue-engineered collagen membrane surface texturing device.

[0017] Figure 2 This is a schematic diagram of the napping roller assembly.

[0018] Figure 3 This is a bottom view of the napping roller assembly.

[0019] Figure 4 This is a schematic diagram (horizontal cross-sectional view) showing the arrangement of the first napping roller, the second napping roller, the first napping roller comb, and the second napping roller comb.

[0020] Figure 5 This is a schematic diagram of the napping needle structure.

[0021] Figure 6 This is a schematic diagram of the napping roller support structure.

[0022] Figure 7 This is a schematic diagram of the structure of the first napping roller.

[0023] Figure 8 This is a schematic diagram of the second napping roller.

[0024] Figure 9 This is a schematic diagram of the first wool roller comb.

[0025] Figure 10 This is a schematic diagram of the second wool roller comb.

[0026] Explanation of reference numerals in the attached drawings: 1. Frame, 2. Electric motor, 3. Transmission device, 4. Pile roller assembly, 101. Electric motor mounting platform, 102. Pile roller assembly mounting platform, 103. Sample handling platform, 104. Sample recovery platform, 301. Belt drive pulley, 302. Meshing gear, 303. Transmission gear, 401. Pile roller support, 402. First pile roller, 403. Second pile roller, 404. First pile roller comb, 405. Second pile roller comb, 406. First meshing gear, 407. Second meshing gear. Detailed Implementation

[0027] Figure 1The diagram shows a tissue-engineered collagen membrane surface texturing device, including a frame 1, a motor 2, a transmission device 3, and a texturing roller assembly 4. The frame 1 includes a motor mounting platform 101 located at the rear of the frame 1, a texturing roller assembly mounting platform 102 extending vertically upwards from the middle of the frame 1, a sample operating platform 103 fixed to the top of the texturing roller assembly mounting platform 102, and a sample recovery platform 104 fixed to the bottom front of the texturing roller assembly mounting platform 102. The sample to be processed is input into the texturing roller assembly through the inlet at the bottom of the sample operating platform 103. The surface of the sample is processed by the rolling and pressing action of the texturing roller assembly. After processing, the sample is input into the sample recovery platform 104 from the bottom outlet of the texturing roller assembly for sample recovery.

[0028] The napping roller assembly includes Figure 2 The shown napping roller bracket 401 has a first napping roller 402 and a second napping roller 403 mounted parallel to each other within the mounting cavity of the napping roller bracket 401; wherein, one end of the first napping roller 402 extending beyond the axial ends of the napping roller bracket 401 is fixed with a meshing gear 302, and the other end meshes with a second meshing gear 407 at the corresponding end of the second napping roller 403 via a first meshing gear 406; see also Figure 1 It can be seen that the motor 2 is connected to the transmission gear 303, which is installed on the napping roller assembly mounting platform 102 and meshes with the meshing gear 302, via the belt drive pulley 301. The synchronous operation of the first napping roller 402 and the second napping roller 403 is achieved through the belt, the transmission gear 303, the meshing gear 302 and the second meshing gear 407.

[0029] Depend on Figure 2 As can be seen, multiple [items] are evenly distributed on the surface of the first napping roller 402. Figure 5 As shown ( Figure 5 The upper right corner shows an enlarged view of the napping needle. The distance from the tip of the napping needle to the central axis of the first napping roller 402 is smaller than the radius of the first napping roller 402, with a difference ranging from 0.01 to 0.05 mm. Figure 5 The upper right corner shows an enlarged view of the napping needle, which has a sharp tip and symmetrically distributed hooks at the end, with 2 to 4 hooks; the distance between the tip of the napping needle and the bottom of the hook is 0.1 to 0.2 mm. The second napping roller 403 is a smooth circular roller; the second napping roller 403 has the same radius as the first napping roller 402, ensuring that the two operate synchronously.

[0030] Depend on Figure 3 As can be seen, a first pile roller comb 404 and a second pile roller comb 405 are respectively provided on two opposing inner sidewalls extending axially from the mounting cavity of the pile roller bracket 401; the first pile roller comb 404 is located on one side of the first pile roller 402, and the first pile roller comb 404 is provided with Figure 9 The comb teeth shown are evenly spaced along the axial direction, with the spacing between the comb teeth allowing the napping needles on the first napping roller 402 to pass through during rotation; the edges of the comb teeth of the first napping roller comb 404 are spaced 0.01 to 0.05 mm from the bottom curved surface of the napping needles on the first napping roller 402; the second napping roller comb 405 is located on one side of the second napping roller 403, and the surface of the second napping roller comb 405 is as shown in the figure. Figure 10 The surface shown is smooth and without comb teeth, with its edge spaced 0.01 to 0.05 mm from the curved surface of the second napping roller 403.

[0031] Finally, it should be noted that the motor 2 selected here is a three-phase asynchronous motor. The frame 1, the first flocking roller 402, and the second flocking roller 403, among other components, are all made of 304 or 316 stainless steel to meet the requirements for medical device production. Furthermore, this tissue-engineered collagen membrane surface flocking device is suitable for flocking dry tissue-engineered collagen membrane materials.

[0032] In summary, it is easy to see that the working principle of this tissue-engineered collagen membrane surface texturing device is to insert the tissue-engineered collagen membrane onto the surface of the collagen membrane via texturing needles on a texturing roller, and to texture the collagen membrane by means of hooks on the texturing needles when the collagen membrane separates from the texturing roller. This invention mainly includes a frame, a motor, a transmission device, and a texturing roller assembly. The frame provides mounting support for each component, the motor provides rotational kinetic energy, the transmission device transmits power, and the texturing roller assembly textures the surface of the tissue-engineered collagen membrane material. This tissue-engineered collagen membrane surface texturing device has the dual functions of "needling" and "hooking." This invention has a simple structure, low cost, and can be effectively industrialized.

[0033] The above description, in conjunction with specific preferred embodiments, provides a further detailed explanation of the present invention. It should not be construed that the specific implementation of the present invention is limited to these descriptions. For those skilled in the art, various simple deductions or substitutions can be made without departing from the concept of the present invention, and all such modifications and substitutions should be considered within the scope of protection of the present invention.

Claims

1. A tissue-engineered collagen membrane surface texturing device, characterized in that, It includes a frame (1), an electric motor (2), a transmission device (3), and a napping roller assembly (4); The frame (1) includes a motor mounting platform (101) located at the rear of the frame (1), a napping roller assembly mounting platform (102) extending vertically upward in the middle of the frame (1), a sample operation platform (103) fixed to the top of the napping roller assembly mounting platform (102), and a sample recovery platform (104) fixed to the bottom front of the napping roller assembly mounting platform (102); The napping roller assembly includes a napping roller bracket (401), a first napping roller (402) and a second napping roller (403) installed parallel to each other in the mounting cavity of the napping roller bracket (401); A meshing gear (302) is fixed at one end of the first napping roller (402) extending beyond the axial ends of the napping roller support (401), and the other end meshes with the second meshing gear (407) at the corresponding end of the second napping roller (403) through the first meshing gear (406); The electric motor (2) is connected to the transmission gear (303) mounted on the napping roller assembly mounting platform (102) and meshing with the meshing gear (302) via a belt drive pulley (301); The first napping roller (402) has a plurality of napping needles evenly distributed on its surface. The distance from the tip of the napping needle to the central axis of the first napping roller (402) is smaller than the radius of the first napping roller (402), and the difference ranges from 0.01 to 0.05 mm. The tip of the napping needle is sharp and has symmetrically distributed hooks at the end, with 2 to 4 hooks. The distance between the tip of the napping needle and the bottom of the hook is 0.1 to 0.2 mm. The second napping roller (403) is a smooth circular roller; the second napping roller (403) has the same radius as the first napping roller (402).

2. The tissue-engineered collagen membrane surface texturing device according to claim 1, characterized in that, The first pile roller comb (404) and the second pile roller comb (405) are respectively provided on the two opposing inner side walls of the mounting cavity extending axially from the pile roller bracket (401); The first pile roller comb (404) is located on one side of the first pile roller (402), and the first pile roller comb (404) is provided with comb teeth that are evenly distributed along the axial direction. The spacing between the comb teeth is sufficient to allow the pile needles on the first pile roller (402) to pass through when rotating. The edge of the comb teeth of the first pile roller comb (404) is 0.01 to 0.05 mm away from the bottom curved surface of the pile needle on the first pile roller (402); The second pile roller comb (405) is located on one side of the second pile roller (403), and the surface of the second pile roller comb (405) is smooth and without comb teeth, and its edge is 0.01 to 0.05 mm away from the curved surface of the second pile roller (403).

3. The tissue-engineered collagen membrane surface texturing device according to claim 1 or 2, characterized in that, The motor (2) is a three-phase asynchronous motor.

4. The tissue-engineered collagen membrane surface texturing device according to claim 1 or 2, characterized in that, The frame (1), the first napping roller (402), and the second napping roller (403) are all made of 304 stainless steel or 316 stainless steel.

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