A method for preparing female gold pill capable of masking bitter taste

Abstract

A method for preparing Nvjin pills that can mask bitterness comprises the following steps: superfinely grinding Radix Rehmanniae, Codonopsis pilosula, Poria cocos, Licorice root, Cinnamon bark, Fructus Amomi, Tangerine peel, Calcined Red Ochre, Deer Horn Powder, and Donkey-hide Gelatin into superfine powders; grinding Radix Angelicae Sinensis, White Peony Root, Rhizoma Chuanxiong, Stir-fried Atractylodes Macrocephalae, Leonurus japonicus, Cortex Moutan, Prepared Myrrha, Vinegar-processed Corydalis, Ligusticum chuanxiong, Radix Angelicae Dahuricae, Radix Scutellariae, Fructus Trichosanthis, and Vinegar-processed Cyperus rotundus into fine powders; uniformly mixing superfine powders with fine powders, dry-rolling into flakes, and then grinding into fine powders, and adding refined honey to prepare large honey pills. The method effectively masks bitter medicinal materials through superfine grinding and dry tableting, significantly reduces the bitterness of Nvjin pills, and improves the taste of the product.

Description

Technical Field

[0001] The invention belongs to the technical field of preparation of Chinese patent medicines, and relates to a preparation method of Nujin Pills, and in particular to a preparation method of Chinese patent medicines which can effectively cover up the bitter taste of Nujin Pills. Background Art

[0002] Nujin Pills nourish qi and blood, regulate qi and activate blood circulation, and are used for menstrual disorders caused by qi and blood deficiency, qi stagnation and blood stasis, with symptoms such as early menstruation, delayed menstruation, heavy menstruation, fatigue, and abdominal pain during menstruation. Nujin Pills are brown to dark brown water-honey pills or large honey pills, with a fragrant aroma and a sweet and slightly bitter taste.

[0003] The preparation method of Nujin Pills in the "Pharmacopoeia of the People's Republic of China" (2020 edition) is as follows: 140g of Angelica sinensis, 70g of White Peony Root, 70g of Chuanxiong, 70g of Rehmannia Glutinosa, 55g of Codonopsis pilosula, 70g of Atractylodes macrocephala (fried), 70g of Poria cocos, 70g of Licorice, 70g of Cinnamon Bark, 200g of Leonurus japonicus, 70g of Paeonia suffruticosa, 70g of Myrrh (processed), 70g of Corydalis yanhusuo (processed with vinegar), 70g of Ligusticum chuanxiong, 70g of Angelica dahurica, 70g of Scutellaria baicalensis, 70g of Vinegar-processed, 150g of Cyperus rotundus (processed with vinegar), 50g of Amomum villosum, 140g of Citrus reticulata, 70g of Red Ochre (calcined), 150g of Deer Antler Powder, and 70g of Donkey-hide Gelatin. Grind the above 23 ingredients into fine powder, sieve, and mix well. For every 100g of powder, add 35-50g of refined honey and appropriate amount of water to make pills, dry them, and make water-honey pills; or add 120-150g of refined honey to make small or large honey pills.

[0004] In the prescription, 13 Chinese medicinal materials including Angelica sinensis, white peony root, Chuanxiong, Atractylodes macrocephala (fried), Leonurus japonicus, Paeonia suffruticosa, Myrrha (processed), Corydalis yanhusuo (processed with vinegar), Ligusticum chuanxiong, Angelica dahurica, Scutellaria baicalensis, Pleurotus eryngii, and Cyperus rotundus (processed with vinegar) taste bitter, which is difficult for some people to accept and has poor compliance.

[0005] Common bitterness masking techniques for traditional Chinese medicine mainly include adding sweeteners, aromatics, taste bud paralyzers, bitterness blockers to the prescription, or using special processing techniques such as coating, inclusion, microcapsule microspheres, etc. The above bitterness masking methods can certainly mask the bitterness of Nujin Pills to a certain extent, but they all require adding new excipients to the original Nujin Pills prescription.

[0006] Due to regulatory factors, these masking technologies must provide additional verification data to meet drug marketing requirements, which limits the application of these methods in Nujin Pills. Therefore, other methods are needed to mask the bitterness of the bitter herbs in Nujin Pills, reduce the bitterness of the drugs without adding new exogenous excipients, and meet regulatory requirements. Summary of the invention

[0007] The purpose of the present invention is to provide a method for preparing Nujin Pills which can mask the bitterness, so as to effectively reduce the bitterness of Nujin Pills without adding any other auxiliary materials.

[0008] To achieve the above object, the present invention specifically adopts the following method for preparing Nujin Pills capable of masking bitterness, comprising the following steps:

[0009] The 10 Chinese medicinal materials in the prescription of Nujin Pill, namely, Radix Rehmanniae Preparata, Codonopsis Pilosula, Poria, Licorice, Cinnamon Bark, Fructus Amomi, Tangerine Peel, Calcined Red Ochre, Deer Horn Powder and Donkey-hide Gelatin, were ultra-finely ground to obtain ultra-fine powder;

[0010] The 13 Chinese medicinal materials in the prescription of Nujin Pill, including Angelica sinensis, White Peony Root, Chuanxiong, Stir-fried Atractylodes Macrocephala, Motherwort, Paeonia suffruticosa, Prepared Myrrh, Vinegar Prepared Corydalis, Ligusticum chuanxiong, Angelica dahurica, Scutellaria baicalensis, White Fern, Vinegar Prepared Cyperus rotundus, were crushed into fine powder;

[0011] The ultrafine powder and the fine powder are mixed evenly, dry-rolled into flakes, and then crushed into fine powder;

[0012] Add refined honey to make large honey pills.

[0013] Specifically, the mesh size of the ultrafine powder obtained by the ultrafine grinding of the present invention is preferably 1000 mesh to 3000 mesh.

[0014] More specifically, the mesh size of the fine powder pulverized in the present invention is preferably 80 meshes to 200 meshes.

[0015] Ultrafine grinding technology is a high-tech technology developed in the past 20 years, which can grind materials into ultrafine powders of 1250 mesh (10μm) or even 12500 mesh (1μm). Conventional grinding technology can only make the particle size of materials reach 325 mesh (45μm).

[0016] Furthermore, the density of the sheet made by dry rolling of the present invention is preferably 1.3-1.8 g / cm 3 .

[0017] Dry tableting is to mix the drug powder evenly, and then compress the drug into a block or tablet with a certain hardness through a certain pressure. The advantage of dry tableting is that it does not require the use of liquid solutions. As long as the drug powder is compacted and dense, the various material components are evenly bonded together.

[0018] The present invention optimizes the product production process by respectively crushing the bitter Chinese medicinal materials and non-bitter Chinese medicinal materials in the prescription of Nujin Pills, and then mixing them for dry tableting and then crushing them. Without adding any new exogenous masking materials and without changing the source of materials in the prescription, the bitterness of the Chinese medicinal materials in Nujin Pills is effectively masked, and the taste of the Nujin Pills product is improved.

[0019] On the one hand, the bitter Chinese medicinal materials in the Nujin Pills are conventionally pulverized, and the non-bitter Chinese medicinal materials in the Nujin Pills are ultra-finely pulverized by an ultra-fine pulverizer, so that the particle size thereof is reduced, the number of particles thereof is increased, the surface area of ​​the non-bitter Chinese medicinal materials is increased, and more non-bitter Chinese medicinal material particles are used to embed the bitter Chinese medicinal materials, thereby introducing a physical barrier; on the other hand, after dry tableting, the non-bitter Chinese medicinal materials can be tightly bonded together with the bitter Chinese medicinal materials, thereby reducing the interaction between the bitter compounds and the active sites on the human tongue, thereby alleviating the bitterness of the Nujin Pills.

[0020] Therefore, the preparation method of Nujin Pills provided by the present invention can effectively mask the bitter taste of Nujin Pills products, improve the taste of the products, and increase patient compliance. Implementation

[0021] The specific implementation of the present invention is further described in detail below in conjunction with the examples. The following examples are only used to more clearly illustrate the technical solution of the present invention so that those skilled in the art can well understand and utilize the present invention, but not to limit the protection scope of the present invention.

[0022] The production processes, experimental methods or detection methods involved in the embodiments and comparative examples of the present invention are all conventional methods in the prior art unless otherwise specified, and their names and / or abbreviations are all conventional names in the field and are very clear and unambiguous in the relevant application fields. Technicians in the field can understand the conventional process steps based on the names and apply the corresponding equipment to implement them according to conventional conditions or the conditions recommended by the manufacturer.

[0023] The various instruments, equipment, raw materials or reagents used in the embodiments of the present invention are not particularly limited in terms of their sources, and are all conventional products that can be purchased through regular commercial channels, or can be prepared according to conventional methods well known to those skilled in the art. Example

[0024] Example 1

[0025] The 10 Chinese medicinal materials in the prescription of Nujin Pill, namely, Rehmannia root, Codonopsis pilosula, Poria cocos, Licorice root, Cinnamon bark, Amomum villosum, Tangerine peel, Red ochre (calcined), Deer antler powder and donkey hide gelatin, are mixed and then ultrafinely ground to obtain ultrafine powder of 1000 mesh.

[0026] The 13 Chinese medicinal materials in the prescription of Nujin Pills, including Angelica sinensis, White Peony Root, Chuanxiong, Atractylodes macrocephala (fried), Leonurus japonicus, Moutan Cortex, Myrrha (processed), Corydalis yanhusuo (processed with vinegar), Ligusticum chuanxiong, Angelica dahurica, Scutellaria baicalensis, Pleurotus eryngii, and Cyperus rotundus (processed with vinegar), were mixed and crushed to 80 mesh to obtain fine powder.

[0027] The ultrafine powder and fine powder obtained above were mixed evenly and dry pressed into a density of 1.3 g / cm 3The flakes are then crushed into 80-mesh fine powder and added to refined honey to make large honey pills.

[0028] Example 2

[0029] The 10 Chinese medicinal materials in the prescription of Nujin Pill, namely, Rehmannia root, Codonopsis pilosula, Poria cocos, Licorice root, Cinnamon bark, Amomum villosum, Tangerine peel, Red ochre (calcined), Deer antler powder and donkey hide gelatin, are mixed and then ultrafinely ground to obtain ultrafine powder of 2000 mesh.

[0030] The 13 Chinese medicinal materials in the prescription of Nujin Pills, including Angelica sinensis, White Peony Root, Chuanxiong, Atractylodes macrocephala (fried), Leonurus japonicus, Moutan Cortex, Myrrha (processed), Corydalis yanhusuo (processed with vinegar), Ligusticum chuanxiong, Angelica dahurica, Scutellaria baicalensis, Pleurotus eryngii, and Cyperus rotundus (processed with vinegar), were mixed and crushed to 80 mesh to obtain fine powder.

[0031] The ultrafine powder and fine powder obtained above were mixed evenly and dry pressed into a density of 1.6 g / cm 3 The flakes are then crushed into 80-mesh fine powder and added to refined honey to make large honey pills.

[0032] Example 3

[0033] The 10 Chinese medicinal materials in the prescription of Nujin Pill, namely, Rehmannia root, Codonopsis pilosula, Poria cocos, Licorice root, Cinnamon bark, Amomum villosum, Tangerine peel, Red ochre (calcined), Deer antler powder and donkey hide gelatin, are mixed and ultrafinely ground to obtain ultrafine powder of 3000 mesh.

[0034] The 13 Chinese medicinal materials in the prescription of Nujin Pills, including Angelica sinensis, White Peony Root, Chuanxiong, Atractylodes macrocephala (fried), Leonurus japonicus, Moutan Cortex, Myrrha (processed), Corydalis yanhusuo (processed with vinegar), Ligusticum chuanxiong, Angelica dahurica, Scutellaria baicalensis, Pleurotus eryngii, and Cyperus rotundus (processed with vinegar), were mixed and crushed to 80 mesh to obtain fine powder.

[0035] The ultrafine powder and fine powder obtained above were mixed evenly and dry pressed into a density of 1.8 g / cm 3 The flakes are then crushed into 80-mesh fine powder and added to refined honey to make large honey pills.

[0036] Comparative Example 1

[0037] The 23 Chinese medicinal materials in the prescription of Nujin Pill, including Rehmannia root, Codonopsis pilosula, Poria cocos, licorice, cinnamon bark, Amomum villosum, dried tangerine peel, red ochre (calcined), antler powder, donkey-hide gelatin, Angelica sinensis, white peony root, Ligusticum chuanxiong, Atractylodes macrocephala (fried), Leonurus japonicus, Paeonia suffruticosa, Myrrha (processed), Corydalis yanhusuo (processed with vinegar), Ligusticum chuanxiong, Angelica dahurica, Scutellaria baicalensis, Pleurotus eryngii, and Cyperus rotundus (processed with vinegar), are mixed and crushed into 80-mesh fine powder.

[0038] Mix the fine powder thoroughly and add refined honey to make large honey pills.

[0039] Comparative Example 2

[0040] The 23 Chinese medicinal materials in the prescription of Nujin Pill, including Rehmannia root, Codonopsis pilosula, Poria cocos, Licorice root, Cinnamon bark, Amomum villosum, Tangerine peel, Red ochre (calcined), Deer antler powder, donkey-hide gelatin, Angelica sinensis, White peony root, Ligusticum chuanxiong, Atractylodes macrocephala (fried), Leonurus japonicus, Paeonia suffruticosa, Myrrha (processed), Corydalis yanhusuo (processed with vinegar), Ligusticum chuanxiong, Angelica dahurica, Scutellaria baicalensis, Pleurotus eryngii, and Cyperus rotundus (processed with vinegar), are mixed and ultrafinely ground to obtain ultrafine powder of 2000 mesh.

[0041] The ultrafine powder is dry pressed to a density of 1.6g / cm 3 The flakes are then crushed into 80-mesh fine powder and added to refined honey to make large honey pills.

[0042] Comparative Example 3

[0043] The 10 Chinese medicinal materials in the prescription of Nujin Pill, including Rehmannia root, Codonopsis pilosula, Poria cocos, Licorice root, Cinnamon bark, Amomum villosum, Tangerine peel, Red ochre (calcined), Deer antler powder and donkey-hide gelatin, were mixed and crushed to 80 mesh to obtain fine powder.

[0044] The 13 Chinese medicinal materials in the prescription of Nujin Pill, including Angelica sinensis, White Peony Root, Chuanxiong, Atractylodes macrocephala (fried), Leonurus japonicus, Paeonia suffruticosa, Myrrha (processed), Corydalis yanhusuo (processed with vinegar), Ligusticum chuanxiong, Angelica dahurica, Scutellaria baicalensis, Fructus rubrae, and Cyperus rotundus (processed with vinegar), are mixed and ultrafinely ground to 2000 mesh to obtain ultrafine powder.

[0045] The fine powder and ultrafine powder obtained above were mixed evenly and dry pressed into a density of 1.6 g / cm 3 The flakes are then crushed into 80-mesh fine powder and added to refined honey to make large honey pills.

[0046] Comparative Example 4

[0047] The 10 Chinese medicinal materials in the prescription of Nujin Pill, namely, Rehmannia root, Codonopsis pilosula, Poria cocos, Licorice root, Cinnamon bark, Amomum villosum, Tangerine peel, Red ochre (calcined), Deer antler powder and donkey hide gelatin, are mixed and then ultrafinely ground to obtain ultrafine powder of 2000 mesh.

[0048] The 13 Chinese medicinal materials in the prescription of Nujin Pills, including Angelica sinensis, White Peony Root, Chuanxiong, Atractylodes macrocephala (fried), Leonurus japonicus, Moutan Cortex, Myrrha (processed), Corydalis yanhusuo (processed with vinegar), Ligusticum chuanxiong, Angelica dahurica, Scutellaria baicalensis, Pleurotus eryngii, and Cyperus rotundus (processed with vinegar), were mixed and crushed to 80 mesh to obtain fine powder.

[0049] The ultrafine powder and fine powder obtained above are evenly mixed, and refined honey is added to make large honey pills.

[0050] The bitterness intensity of the Nujin Pills prepared in the above-mentioned embodiments and comparative examples was evaluated by tasting method.

[0051] Bitterness intensity is divided into 5 levels: 0 is no bitterness; 1 is slightly bitter; 2 is acceptable bitterness; 3 is very bitter but tolerable bitterness; 4 is unbearable bitterness.

[0052] The evaluation team consists of 10 qualified reviewers. All drug samples have the same weight. The time for tasting a sample is 3-6 seconds, and the interval between tasting different samples is 10 minutes. After tasting all samples, the same reviewer scores them according to the bitterness intensity, compares the bitterness of the samples, and ranks them.

[0053] The evaluation results of the products prepared in the above Examples 1-3 and Comparative Examples 1-4 are listed in Table 1.

[0054]

[0055] As can be seen from Table 1 above, the bitterness intensity of the Nujin Pills prepared by the method of the present invention in Examples 1-3 is all level 2, proving that the method of the present invention can effectively reduce the bitterness of the drug by increasing the mesh size of the non-bitter Chinese medicinal materials by ultrafine grinding, and further increasing the density of the tablets by dry pressing. The reason is that the mesh size of the non-bitter Chinese medicinal materials increases, and the number of non-bitter material particles increases exponentially, which is equivalent to diluting the bitter material. The non-bitter material forms a wrap around the bitter material. At the same time, after dry pressing, the two are tightly bonded together, reducing the contact probability of the bitter material with the tongue. Ultrafine grinding and dry tableting effectively cover the bitter Chinese medicinal materials.

[0056] The bitterness intensity of the Nujin Pills prepared in Comparative Examples 1-4 in Table 1 is 1-2 levels higher than that of the present invention, and the bitterness is obvious.

[0057] In particular, the bitterness intensity of Comparative Example 3 reached the highest level of 4, which means that the bitter Chinese medicinal materials in Nujin Pills were ultrafinely ground, while the non-bitter Chinese medicinal materials were conventionally ground. Not only did the non-bitter Chinese medicinal materials fail to dilute and wrap the bitter Chinese medicinal materials, but it was equivalent to amplifying the bitterness of the bitter Chinese medicinal materials, so its bitterness intensity was the highest.

[0058] The bitterness intensity of Nujin Pills prepared in Comparative Examples 1, 2 and 4 is similar. However, Comparative Examples 1 and 2 do not distinguish between bitter Chinese medicinal materials and non-bitter Chinese medicinal materials, and the method of crushing all medicinal materials into the same mesh size cannot play the role of diluting and wrapping the bitter Chinese medicinal materials by non-bitter Chinese medicinal materials, and cannot effectively cover the bitterness of Nujin Pills; at the same time, the method of ultrafine grinding used in Comparative Example 2 also strengthens the bitterness of bitter Chinese medicinal materials, so the bitterness of Comparative Example 2 is stronger than that of Comparative Example 1.

[0059] Although Comparative Example 4 forms a dilution and encapsulation effect on the bitter Chinese medicinal materials by the non-bitter Chinese medicinal materials, due to the lack of dry pressing processing means, the non-bitter Chinese medicinal materials and the bitter Chinese medicinal materials are not tightly bonded, the encapsulation effect is not optimal, and the probability of the bitter material particles contacting the tongue is still relatively high. Therefore, although its bitterness is the lowest among the comparative examples, it is still higher than the bitterness of the Nujin Pills prepared by the present invention.

[0060] The above embodiments of the present invention do not describe all the details in detail, nor limit the present invention to the above embodiments. Various changes, modifications, substitutions and variations made by ordinary technicians in this field without departing from the principles and purpose of the present invention should be included in the protection scope of the present invention.

Claims

1. A method for preparing Nujin Pills capable of masking bitterness, the method comprising: The 10 Chinese medicinal materials in the prescription of Nujin Pill, namely, Radix Rehmanniae Preparata, Codonopsis Pilosula, Poria, Licorice, Cinnamon Bark, Fructus Amomi, Tangerine Peel, Calcined Red Ochre, Deer Horn Powder and Donkey-hide Gelatin, were ultra-finely ground to obtain ultra-fine powder; The 13 Chinese medicinal materials in the prescription of Nujin Pill, including Angelica sinensis, White Peony Root, Chuanxiong, Stir-fried Atractylodes Macrocephala, Motherwort, Paeonia suffruticosa, Prepared Myrrh, Vinegar Prepared Corydalis, Ligusticum chuanxiong, Angelica dahurica, Scutellaria baicalensis, White Fern, Vinegar Prepared Cyperus rotundus, were crushed into fine powder; The ultrafine powder and the fine powder are mixed evenly, dry-rolled into flakes, and then crushed into fine powder; Add refined honey to make large honey pills; Wherein, the mesh size of the superfine powder is 1000-3000 mesh, and the mesh size of the fine powder is 80-200 mesh.

2. The method for preparing the bitter-tasting Nujin Pill according to claim 1, characterized in that The density of the dry-rolled sheet is 1.3-1.8 g / cm 3 .

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