A bactericidal composition containing Cyclobutrifluram and its application

Abstract

This invention belongs to the field of pesticide fungicide technology, and discloses a fungicide composition containing Cyclobutrifluram and its application. The active ingredients of the fungicide composition include Cyclobutrifluram and prochloraz or its salt, and the mass ratio of Cyclobutrifluram to prochloraz or its salt is 1:50 to 54:1. The fungicide composition of this invention has significant control effect on wheat scab, can effectively slow down the development of the disease, reduce the amount of pesticides used, and is environmentally safe.

Description

Technical Field

[0001] This invention belongs to the field of pesticide sterilization technology, and discloses a sterilization composition containing Cyclobutrifluram and its application. Background Technology

[0002] Fusarium graminearum Schw, a fungus causing wheat scab, is one of the major diseases in the winter wheat regions of the middle and lower reaches of the Yangtze River, the winter wheat regions of South China, and the spring wheat regions of Northeast my country.

[0003] In recent years, due to combined harvesting operations, straw return to the field in corn-wheat dual-cropping areas, and changes in climate and irrigation conditions, the occurrence area of ​​wheat scab has been continuously expanding, especially in North China where the occurrence of wheat scab has become increasingly serious, becoming an urgent problem to be solved in agricultural production.

[0004] Because some pesticides can produce synergistic effects when combined, the efficacy of fungicide combinations is receiving increasing attention. Scientifically combining fungicides can not only reduce the risk of pathogens developing resistance, but also achieve better control effects than simply increasing the dosage of a single fungicide, and significantly reduce the difficulty of developing new fungicides. However, whether a synergistic effect will occur after combination is difficult to predict. The applicant, through indoor experiments, found that Cyclobutrifluram, when combined with prochloraz or its salts in an appropriate mass ratio, has a significant synergistic effect against wheat scab. Further verification through field efficacy trials yielded a fungicide composition with good control efficacy against wheat scab. However, there are no reports on fungicide compositions combining Cyclobutrifluram with prochloraz or its salts and their use in controlling wheat scab. Summary of the Invention

[0005] In view of the above problems, the present invention provides a fungicide composition that has excellent control effect on plant diseases, especially wheat scab, which has a significant synergistic effect, can effectively slow down the spread of the disease, slow down the development of pathogen resistance, reduce the dosage of pesticides, and is safe for crops and environmentally friendly.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a bactericidal composition containing Cyclobutrifluram, wherein the bactericidal composition comprises active ingredient A and active ingredient B, wherein active ingredient A is Cyclobutrifluram, and active ingredient B is imazalil or its salt, and the mass ratio of active ingredient A to active ingredient B is 1:50 to 54:1.

[0007] Furthermore, the imazalil salt is selected from imazalil manganese salt or imazalil copper salt;

[0008] Furthermore, the active ingredient B is imazalil, and the mass ratio of active ingredient A to active ingredient B is 1:32 to 48:1;

[0009] The active ingredient B is imazalil manganese salt, and the mass ratio of active ingredient A to active ingredient B is 1:50 to 54:1;

[0010] The active ingredient B is copper imazalil salt, and the mass ratio of active ingredient A to active ingredient B is 1:32 to 40:1.

[0011] Furthermore, the active ingredient B is imazalil, and the mass ratio of active ingredient A to active ingredient B is 1:16 to 32:1;

[0012] The active ingredient B is imazalil manganese salt, and the mass ratio of active ingredient A to active ingredient B is 1:32 to 32:1;

[0013] The active ingredient B is copper imazalil salt, and the mass ratio of active ingredient A to active ingredient B is 1:16 to 32:1.

[0014] Furthermore, based on the total weight of the bactericidal composition being 100 wt%, the total weight of the active ingredient Cyclobutrifluram and imazalil or its salt accounts for 1% to 70% of the total weight of the bactericidal composition.

[0015] Furthermore, the bactericidal composition, in addition to containing the active ingredient, also contains pesticide-acceptable auxiliary ingredients, which are selected from one or more of the following: wetting agents, dispersants, emulsifiers, thickeners, disintegrants, antifreeze agents, defoamers, solvents, preservatives, stabilizers, synergists, binders, fillers, or carriers.

[0016] Further, the wetting agent is selected from one or more of alkylbenzene sulfonates, alkylnaphthalene sulfonates, lignin sulfonates, sodium dodecyl sulfate, sodium dioctyl succinate sulfonate, α-olefin sulfonates, alkylphenol polyoxyethylene ethers, castor oil polyoxyethylene ethers, alkylphenol ethoxylates, fatty alcohol ethoxylates, sodium fatty alcohol polyoxyethylene ether sulfate, silkworm excrement, soapberry powder, soapberry powder, SOPA, detergents, emulsifiers 2000 series, and wetting and penetrating agents F; and / or

[0017] The dispersant is selected from one or more of the following: lignin sulfonates, alkyl naphthalene sulfonates formaldehyde condensates, naphthalene sulfonates, tristyrylphenol ethoxylate phosphates, fatty alcohol ethoxylates, alkylphenol polyoxyethylene ethers, alkylphenol polyoxyethylene ether methyl ether condensates sulfates, fatty amine polyoxyethylene ethers, glycerol fatty acid ester polyoxyethylene ethers, polycarboxylates, polyacrylic acids, phosphates, EO-PO block copolymers, and EO-PO graft copolymers; and / or

[0018] The emulsifier is selected from one or more of the following: calcium dodecylbenzenesulfonate, alkylphenol formaldehyde resin polyoxyethylene ether, phenethylphenol polyoxyethylene polyoxypropylene ether, fatty alcohol ethylene oxide-propylene oxide copolymer, styrene-phenol polyoxyethylene ether, castor oil polyoxyethylene ether, and alkylphenol ether phosphate; and / or

[0019] The thickener is selected from one or more of xanthan gum, organobentonite, gum arabic, sodium alginate, magnesium aluminum silicate, carboxymethyl cellulose, and silica; and / or

[0020] The disintegrant is selected from one or more of sodium sulfate, ammonium sulfate, aluminum chloride, sodium chloride, ammonium chloride, bentonite, glucose, sucrose, starch, cellulose, urea, sodium carbonate, sodium bicarbonate, citric acid, and tartaric acid; and / or

[0021] Antifreeze is selected from one or more of alcohols, alcohol ethers, chlorinated hydrocarbons, and inorganic salts; and / or

[0022] Defoamer selected from C 10 -C 20 Saturated fatty acid compounds, silicone oil, silicone compounds, C8-C 10 One or more of the fatty alcohols; and / or

[0023] The solvent is selected from one or more of benzene, toluene, xylene, mesitylene, methanol, ethanol, isopropanol, n-butanol, dimethyl sulfoxide, dimethylformamide, cyclohexanone, hydrocarbon carbonates, diesel oil, solvent oil, vegetable oil, vegetable oil derivatives, and water; and / or

[0024] The preservative is selected from one or more of propionic acid, sodium propionate, sorbic acid, sodium sorbate, potassium sorbate, benzoic acid, sodium benzoate, sodium p-hydroxybenzoate, methyl p-hydroxybenzoate, Kathon, and 1,2-benzisothiazolin-3-one; and / or

[0025] The stabilizer is selected from one or more of the following: disodium hydrogen phosphate, oxalic acid, succinic acid, adipic acid, borax, 2,6-di-tert-butyl-p-cresol, triethanolamine oleate, epoxidized vegetable oil, kaolin, bentonite, attapulgite, silica, talc, montmorillonite, and starch; and / or

[0026] Synergists are selected from synergistic phosphorus, synergistic ether; and / or

[0027] The carrier is selected from one or more of the following: ammonium salts, ground natural minerals, ground artificial minerals, silicates, resins, waxes, solid fertilizers, water, organic solvents, mineral oils, vegetable oils, and vegetable oil derivatives.

[0028] Furthermore, the bactericidal composition can be prepared into a pesticide-acceptable formulation, wherein the formulation is a microemulsion, water-in-oil emulsion, suspension, dispersible oil suspension, soluble concentrate, emulsifiable concentrate, suspension emulsion, microcapsule suspension, water-dispersible granules, wettable powder, or granules.

[0029] Furthermore, the formulation is a water-dispersible granule, wettable powder, suspension concentrate, water emulsion, emulsifiable concentrate, or microemulsion.

[0030] The present invention also discloses the use of the bactericidal composition described above for the prevention and control of plant diseases.

[0031] Furthermore, the plant disease mentioned is wheat scab.

[0032] The beneficial effects of the present invention are as follows: the bactericidal composition of the present invention rationally combines compounds with different mechanisms of action, alleviates the resistance problem of old agents, improves the control effect on wheat scab, reduces the dosage of pesticides, is safe for crops, and is environmentally friendly. Detailed Implementation

[0033] To make the objectives, advantages, and technical solutions of this invention clearer, the following formulation preparation examples and specific embodiments are used to explain and illustrate the technical solutions of this invention. However, the scope of protection of this invention should not be limited by the specific embodiments described herein.

[0034] Formulation preparation example:

[0035] Preparation Example 1: 27% Cyclobutrifluram·Imidacloprid water-dispersible granules (8:1)

[0036] Formula composition: 24% Cyclobutrifluram, 3% imazalil, 8% sodium lignosulfonate, 10% sodium polycarboxylate, 2% sodium dodecyl sulfate, 5% silica, 28% starch, and kaolin to make up the balance.

[0037] Preparation method: According to the formula ratio, mix imazalil and silica evenly, then add the active ingredient to the carrier, and add surfactants and other functional additives. Mix, and after air jet milling, add 10-25% water, then knead, granulate, dry and sieve to obtain water-dispersible granules; or spray water, granulate and dry the pulverized powder in a fluidized bed granulator, and then sieve to obtain the product.

[0038] Preparation Example 2: 30% Cyclobutrifluram·Imidacloprid wettable powder (4:1)

[0039] Formula composition: 24% Cyclobutrifluram, 6% imazalil, 2% Gelbert alcohol polyoxyethylene ether, 15% silica, 6% naphthalene sulfonate formaldehyde condensate, 10% tea saponin, 2% sodium dodecyl sulfate, kaolin to make up the balance;

[0040] Preparation method: According to the formulation ratio in the example, imazalil and silica are mixed evenly, the active ingredient is added to the carrier, and surfactants and other functional additives are added to it. After mixing, the mixture is pulverized by air jet and then mixed again to obtain a wettable powder product.

[0041] Preparation Example 3: 25% Cyclobutrifluram·Imidacloprid EC (1:1)

[0042] Formula composition: 12.5% ​​Cyclobutrifluram, 12.5% ​​imazalil, 20% N-methylpyrrolidone, 10% styrene-based phenolic polyoxyethylene ether, 2% calcium dodecylbenzenesulfonate, 10% DMF, methyl oleate to make up the balance.

[0043] Preparation method: According to the formula ratio, add the active ingredient, solvent and co-solvent into the mixing tank and stir to dissolve them. Then add the emulsifier, and use the remaining solvent to make up the balance. Stir evenly in the mixing tank, and filter to obtain the emulsifiable oil required by the present invention.

[0044] Preparation Example 4: 7.5% Cyclobutrifluram·Imidacloprid water emulsion (4:1)

[0045] Formula composition: 6% Cyclobutrifluram, 1.5% imazalil, 10% xylene, 10% cyclohexanone, 1% tristyrene phenol ethoxylate phosphate, 8% ethylene oxide-propylene oxide copolymer, 4% ethylene glycol, 1% glycerin, 0.05% silicone defoamer, 0.1% xanthan gum, 0.1% sodium benzoate, water to make up the balance;

[0046] Preparation method: According to the formulation ratio in the example, the active ingredient is dissolved in the solvent and an emulsifier is added to form a homogeneous oil phase. Deionized water and antifreeze are mixed together to form a homogeneous aqueous phase. Under high-speed shearing, the aqueous phase is added to the oil phase to form a well-dispersed water emulsion product.

[0047] Preparation Example 5: 9% Cyclobutrifluram·Imidacloprid microemulsion (8:1)

[0048] Formula composition: 8% Cyclobutrifluram, 1% imazalil, 20% cyclohexanone, 12% fatty alcohol polyoxyethylene ether, 3% sorbitan oleate polyoxyethylene ether, 1% fatty alcohol polyoxyethylene ether sulfate, 0.05% silicone defoamer, deionized water to make up the balance;

[0049] Preparation method: According to the formulation ratio in the example, the active ingredients, solvent, emulsifier, etc. are mixed evenly to obtain the oil phase, the antifreeze is mixed evenly with water to obtain the aqueous phase, the oil phase is added to the aqueous phase under stirring and stirred evenly, shearing is continued for 10 minutes, and then the defoamer is added and stirred evenly to obtain small droplets with oil phase particles of 0.01 to 0.1 micrometers, which is the microemulsion product.

[0050] Preparation Example 6: 32% Cyclobutrifluram·Imidacloprid Manganese Salt Suspension (15:1)

[0051] Formula composition: 30% Cyclobutrifluram, 2% imazalil manganese salt, 1% sodium succinate sulfonate, 2% naphthalene sulfonate formaldehyde condensate, 3% alkylphenol polyoxyethylene ether phosphate, 0.2% xanthan gum, 1% magnesium aluminum silicate, 5% ethylene glycol, 0.01% Kathon, 0.5% silicone defoamer, deionized water to make up the balance;

[0052] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in the reaction vessel in sequence, water is added and mixed evenly, and then subjected to high-speed shearing, wet sand milling and finally homogenization filtration to obtain the suspension product.

[0053] Preparation Example 7: 42% Cyclobutrifluram·Imidacloprid Manganese Salt Wettable Powder (2:1)

[0054] Formula composition: 28% Cyclobutrifluram, 14% imazalil manganese salt, 10% sodium lignosulfonate, 8% sodium polycarboxylate, 8% starch, 5% silica, kaolin to make up the balance;

[0055] Preparation method: Same as in preparation example 2.

[0056] Preparation Example 8: 35% Cyclobutrifluram·Imidacloprid Manganese Salt Wettable Powder (1:6)

[0057] Formula composition: 5% Cyclobutrifluram, 30% imazalil manganese salt, 10% sodium lignosulfonate, 2% sodium dodecyl sulfate, 5% sodium polycarboxylate, 7% starch, 5% silica, kaolin to make up the balance;

[0058] Preparation method: Same as in preparation example 2.

[0059] Preparation Example 9: 36% Cyclobutrifluram·prochloraz copper salt suspension (8:1)

[0060] Formula composition: 32% Cyclobutrifluram, 4% imazalil copper salt, 1% alkylphenol polyoxyethylene ether, 4% styrene phenol polyoxyethylene ether phosphate, 1% sodium lignosulfonate, 0.25% xanthan gum, 5% ethylene glycol, 0.1% Kathon, 0.5% silicone oil, deionized water to make up the balance;

[0061] Preparation method: Same as in preparation example 6.

[0062] Preparation Example 10: 38% Cyclobutrifluram·prochloraz copper salt suspension (1:1)

[0063] Formula composition: 19% Cyclobutrifluram, 19% copper imazalil salt, 1% fatty alcohol polyoxyethylene ether, 2% glycerol fatty acid ester polyoxyethylene ether, 2% styrene phenol polyoxyethylene ether sulfate, 1% sodium polycarboxylate, 1% magnesium aluminum silicate, 0.1% carboxyethyl cellulose, 1% sodium sorbate, 5% glycerol, 0.5% silicone oil, deionized water to make up the balance;

[0064] Preparation method: Same as in preparation example 6.

[0065] Indoor activity test:

[0066] Example 1: Indoor activity test of Cyclobutrifluram combined with prochloraz or its salts against wheat scab.

[0067] Experimental basis: The experiment was conducted in accordance with NY / T 1156.2-2006, the Agricultural Industry Standard of the People's Republic of China, "Guidelines for Indoor Bioassay Tests of Pesticides - Fungicides Part 2: Tests for Inhibition of Mycelial Growth of Pathogenic Fungi - Plate Method".

[0068] Experimental target: Fusarium graminearum.

[0069] Instruments and equipment: moist heat sterilizer, ultra-clean workbench, constant temperature and light incubator, electric heating drum and windproof drying oven, 0.01% electronic balance, pipette, alcohol lamp, small beakers, volumetric flasks, Erlenmeyer flasks, petri dishes (Φ9cm), hole punch, inoculator (Φ0.6cm), ruler, etc.

[0070] Test reagents: prochloraz technical, Cyclobutrifluram technical, prochloraz manganese technical, prochloraz copper technical.

[0071] Preparation of pharmaceutical stock solution: Dissolve the above raw materials in a suitable solvent, then dilute with 0.1% Tween 80 aqueous solution to prepare single-dose stock solutions. Design different ratios according to the purpose of mixing and the activity of the drugs. Prepare the required series of mass concentrations for each single agent and each group of mixed solutions.

[0072] Chemical treatment: Under aseptic conditions, pre-melted and sterilized PDA medium was quantitatively added to sterile Erlenmeyer flasks according to the experimental treatment. From low to high concentration, 10 mL of each prepared treatment solution was quantitatively pipetted and added to the Erlenmeyer flasks, thoroughly mixed, and then poured into petri dishes to prepare the corresponding concentration of drug-containing plates. A 0.1% Tween 80 aqueous solution without added drug was set up as a blank control. Each treatment was repeated in quadruplicate.

[0073] Inoculation: Under aseptic conditions, use a sterilized punch to cut off a mycelial cake from the edge of the pre-cultured Fusarium graminearum. Inoculate the mycelial cake into the center of the drug-containing plate with an inoculator, cover with the cap, and place in a constant temperature and light incubator at 26°C for cultivation.

[0074] Data collection: The growth of pathogenic fungal hyphae was investigated based on the growth of hyphae in the blank control culture dishes. The diameter of the colonies was measured in centimeters (cm) using a ruler. The diameter of each colony was measured once using the cross-sectional method, and the average value was taken. The original data of all replicates for each treatment were recorded.

[0075] Data statistics and analysis: Based on the survey results, the inhibition rate of mycelial growth of the tested target bacteria by each treatment concentration was calculated, in percentage (%). The calculation results were retained to two decimal places.

[0076] D = D1 - D2

[0077] In the formula:

[0078] D – Colony growth diameter;

[0079] D1—colony diameter;

[0080] D2 – Diameter of the mushroom cake.

[0081]

[0082] In the formula:

[0083] I – Mycelial growth inhibition rate;

[0084] D0—Correlation diameter of the blank control group;

[0085] D T — Diameter of colonies grown after chemical treatment.

[0086] Analyze using the DPS statistical analysis system to determine EC 50 The value is used to evaluate the activity of the test reagent on the biological sample.

[0087] Sun Yunpei's method: The synergistic effect of drug mixtures is evaluated based on the co-toxicity coefficient (CTC). A CTC ≥ 120 indicates a synergistic effect; a CTC ≤ 80 indicates an antagonistic effect; and a CTC < 120 indicates an additive effect.

[0088] Calculation of the co-toxicity coefficient (CTC value) of the mixture:

[0089]

[0090] In the formula:

[0091] ATI – Actual Measured Toxicity Index of Mixtures;

[0092] S—EC of standard reagent 50 The unit is milligrams per liter (mg / L);

[0093] M – EC of the mixture 50 The unit is milligrams per liter (mg / L).

[0094] TTI = TI A ×P A +TI B ×P B

[0095] In the formula:

[0096] TTI – Theoretical Toxicity Index of Mixtures;

[0097] TI A —A. Toxicity index of drug A;

[0098] P A —Percentage content of drug A in the mixture, expressed as percentage (%);

[0099] TI B —Toxicity index of drug B;

[0100] P B —Percentage content of agent B in the mixture, expressed as percentage (%).

[0101]

[0102] In the formula:

[0103] CTC – Cotoxicity Coefficient;

[0104] ATI – Actual Measured Toxicity Index of Mixtures;

[0105] TTI – Theoretical Toxicity Index of Mixtures.

[0106] The test results are shown in the table below:

[0107] Table 1. Indoor activity test of Cyclobutrifluram combined with prochloraz against wheat scab.

[0108]

[0109] Table 2. Indoor activity test of Cyclobutrifluram combined with manganese prochloraz salt against wheat scab.

[0110]

[0111] Table 3. Indoor activity test of Cyclobutrifluram combined with copper prochloraz salt against wheat scab.

[0112]

[0113]

[0114] The results of the indoor bioactivity assay shown in Table 1-3 above indicate that a reasonable combination of Cyclobutrifluram with prochloraz or its salts, under certain mass ratios, exhibits excellent control effects against wheat scab. When Cyclobutrifluram is combined with prochloraz at a mass ratio of 1:48, the co-toxicity coefficient (CTC) is less than 120, showing an additive effect against wheat scab. However, when the mass ratio is 1:32–48:1, the CTC is greater than 120, indicating a synergistic effect. When Cyclobutrifluram is combined with prochloraz manganese salt at a mass ratio of 1:50–54:1, the CTC is greater than 120, indicating a synergistic effect. When Cyclobutrifluram is combined with prochloraz copper salt at a mass ratio of 1:48 and 48:1, the effect is additive. However, when the mass ratio is 1:32–40:1, the CTC is greater than 120, indicating a synergistic effect.

[0115] Field efficacy trials

[0116] Example 4: Field efficacy test for controlling wheat scab

[0117] Experimental location: Wheat field in Baishuitang Village, Babao Town, Songzi City, Jingzhou, Hubei Province. The experimental field has flat terrain, moderate soil fertility, and sandy loam texture. The previous crop was corn. The cultivation and management conditions of all experimental plots were uniform and consistent, conforming to local scientific agricultural practices.

[0118] Experimental target: Wheat scab.

[0119] Experimental crop: Wheat (Emai 170).

[0120] Experimental design: The experiment consisted of 8 treatments, 7 of which were chemical treatments and 1 water control. Each treatment was repeated 4 times. The experimental plots were arranged in a randomized block design.

[0121] Application time: The first application of pesticide was carried out on April 1, 2022, when the wheat was flowering, and the second application was carried out on April 8, 2022, for a total of 2 applications.

[0122] Experimental survey: The disease survey was conducted on May 16, 2022. Five samples were taken from each plot, and 100 ears were surveyed at each point. The ears were infected with Fusarium head blight. The disease was classified according to the percentage of dead ears to the total ear area. The number of infected ears at each level and the total number of ears were recorded, and the control effect was calculated.

[0123] Grading method:

[0124] Grade 0: Disease-free entire ear of grain;

[0125] Grade 1: The area of ​​dead ears accounts for less than 1 / 4 of the total ear area;

[0126] Grade 3: The area of ​​dead ears accounts for 1 / 4 to 1 / 2 of the total ear area;

[0127] Grade 5: The area of ​​dead ears accounts for 1 / 2 to 3 / 4 of the total ear area;

[0128] Level 7: The area of ​​dead ears accounts for more than 3 / 4 of the total ear area.

[0129] Methods for calculating drug efficacy:

[0130]

[0131]

[0132]

[0133] Results and analysis of efficacy tests:

[0134] Table 4 Results of field efficacy trials for controlling wheat scab.

[0135]

[0136] Pesticide safety: Field observations were conducted 7 days after each application. No symptoms such as stunting, chlorosis, or deformity were observed on the wheat stems and leaves in the experimental areas. Wheat growth was good in both the control and pesticide-treated areas. No phytotoxicity symptoms were observed after application of the experimental pesticide, indicating that it was safe for wheat growth.

[0137] As shown in Table 4, under the condition of a fixed number of ears, after applying the three compound agents, the number of ears infected with wheat scab did not exceed 30, and the disease rate was between 4.30% and 5.95%, the disease index was between 1.46 and 2.36, and the control efficacy was between 88.73% and 93.05%.

[0138] The results of this experiment show that, during the critical period of wheat heading and flowering, after two applications of the fungicidal composition of this invention can effectively control wheat scab, with a control efficacy of over 88%, significantly higher than the control group. After application, no chlorosis, deformities, or other phytotoxic symptoms were observed in the wheat field, and the wheat grew well, indicating that the treatment is safe for wheat growth.

[0139] Although the present invention has been described in detail above with general description and specific embodiments, some modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention are within the scope of protection claimed by the present invention.

Claims

1. A bactericidal composition containing Cyclobutrifluram, characterized in that, The bactericidal composition comprises active ingredient A and active ingredient B, wherein active ingredient A is Cyclobutrifluram, and active ingredient B is imazalil or its salt, and the mass ratio of active ingredient A to active ingredient B is 1:50 to 54:

1.

2. The bactericidal composition according to claim 1, characterized in that, The imazalil salt is selected from imazalil manganese salt or imazalil copper salt.

3. The bactericidal composition according to claim 1, characterized in that, The active ingredient B is imazalil, and the mass ratio of active ingredient A to active ingredient B is 1:32 to 48:1; The active ingredient B is imazalil manganese salt, and the mass ratio of active ingredient A to active ingredient B is 1:50 to 54:1; The active ingredient B is copper imazalil salt, and the mass ratio of active ingredient A to active ingredient B is 1:32 to 40:

1.

4. The bactericidal composition according to claim 1, characterized in that, The active ingredient B is imazalil, and the mass ratio of active ingredient A to active ingredient B is 1:16 to 32:1; The active ingredient B is imazalil manganese salt, and the mass ratio of active ingredient A to active ingredient B is 1:32 to 32:1; The active ingredient B is copper imazalil salt, and the mass ratio of active ingredient A to active ingredient B is 1:16 to 32:

1.

5. The bactericidal composition according to claim 1, characterized in that, Based on a total weight of 100 wt% of the bactericidal composition, the total weight of the active ingredient Cyclobutrifluram and imazalil or its salt accounts for 1 wt% to 70 wt% of the total weight of the bactericidal composition.

6. The bactericidal composition according to claim 1, characterized in that, In addition to the active ingredient, the bactericidal composition contains pesticide-acceptable auxiliary ingredients, which are selected from one or more of the following: wetting agents, dispersants, emulsifiers, thickeners, disintegrants, antifreeze agents, defoamers, solvents, preservatives, stabilizers, synergists, binders, fillers, or carriers.

7. The bactericidal composition according to claim 1, characterized in that, The bactericidal composition can be prepared into a pesticide-acceptable formulation, which is a microemulsion, water-in-oil emulsion, suspension, dispersible oil suspension, soluble concentrate, emulsifiable concentrate, suspension emulsion, microcapsule suspension, water-dispersible granules, wettable powder, or granules.

8. The bactericidal composition according to claim 7, characterized in that, The formulation is a water-dispersible granule, wettable powder, suspension concentrate, water emulsion, emulsifiable concentrate, or microemulsion.

9. Use of the bactericidal composition according to any one of claims 1-8 for the prevention and control of plant diseases.

10. The use according to claim 9, characterized in that, The plant disease mentioned is wheat scab.

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