A traditional Chinese medicine composition for treating chronic gastritis and gastroduodenal ulcer, and its preparation method and application

Abstract

The present invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition for treating chronic gastritis and gastric and duodenal ulcers, as well as its preparation method and application. The pharmaceutical composition comprises the following raw materials in parts by weight: 15-30 parts of bupleurum root, 15-30 parts of poria cocos, 15-30 parts of scutellaria baicalensis, 15-30 parts of white peony root, 10-20 parts of curcuma aromatica, 15-30 parts of gardenia jasminoides, 10-20 parts of fructus aurantii, 15-30 parts of liuqu, 10-20 parts of white cardamom, 10-20 parts of corydalis yanhusuo, 15-30 parts of ophiopogon japonicus, 10-15 parts of cyperus rotundus, 15-30 parts of forsythia suspensa, 15-30 parts of chicken's gizzard lining, 15-30 parts of angelica sinensis, 15-30 parts of isatis root, 1-3 parts of ginger, and 1-3 parts of jujube. The present invention has good clinical efficacy in treating chronic gastritis, gastric ulcers, and duodenal ulcers without causing significant adverse reactions.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating chronic gastritis and gastroduodenal ulcer, and a preparation method and application thereof. Background Art

[0002] Chronic gastritis and gastroduodenal ulcers are the most common digestive system diseases in my country, with a high prevalence, seriously impacting people's quality of life and overall health. Chronic gastric mucosal inflammation, caused by a variety of etiologies and influenced by various pathogenic factors, leads to inflammatory reactions, necrosis, and sloughing of the digestive tract mucosa, resulting in damage. The necrotic defects in the ulcers penetrate the muscularis mucosa. The pathogenesis is primarily related to an imbalance between factors that damage the gastric and duodenal mucosa and those that protect and repair it. Long-term chronic gastric mucosal inflammation can lead to lesions such as atrophy, intestinal metaplasia, and dysplasia. Gastroduodenal ulcers can be complicated by bleeding, perforation, pyloric obstruction, and cancer. However, the increasing antibiotic resistance of Helicobacter pylori, the widespread use of nonsteroidal anti-inflammatory drugs, and the prevalence of antithrombotic therapy in an aging population have made the diagnosis and treatment of chronic gastritis and gastroduodenal ulcers more challenging than ever before.

[0003] Currently, the main clinical treatments for chronic gastritis and gastroduodenal ulcers include acid suppression, gastric mucosal protective agents, and anti-Helicobacter pylori therapies. The main goals of treatment are to improve symptoms, reduce complications, slow disease progression, and promote mucosal repair and ulcer healing. However, all of these medications have significant side effects and should not be taken long-term. Furthermore, the primary clinical challenge facing chronic gastritis and gastroduodenal ulcers is their high recurrence rate, and single-agent therapies cannot achieve the desired results. Practice and research have demonstrated that Traditional Chinese Medicine (TCM) offers significant advantages in treating chronic gastritis and digestive ulcers. Summary of the Invention

[0004] In view of the problems existing in the prior art, the purpose of the present invention is to provide a traditional Chinese medicine composition for treating chronic gastritis and gastroduodenal ulcer, as well as a preparation method and application thereof.

[0005] To achieve the above objectives, the present invention adopts the following technical solutions.

[0006] A pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer comprises the following raw materials in parts by weight: 15-30 parts of bupleurum, 15-30 parts of poria, 15-30 parts of scutellaria, 15-30 parts of white peony root, 10-20 parts of turmeric, 15-30 parts of gardenia, 10-20 parts of fructus aurantii, 15-30 parts of liushenqu, 10-20 parts of white cardamom, 10-20 parts of corydalis, 15-30 parts of ophiopogon, 10-15 parts of cyperus, 15-30 parts of forsythia, 15-30 parts of chicken's gizzard lining, 15-30 parts of angelica, 15-30 parts of isatis root, 1-3 parts of ginger, and 1-3 parts of jujube.

[0007] Furthermore, the pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer comprises the following raw materials in parts by weight: 20 parts of bupleurum, 20 parts of poria, 20 parts of scutellaria, 20 parts of white peony root, 10 parts of turmeric, 20 parts of gardenia, 10 parts of fructus aurantii, 20 parts of liushenqu, 10 parts of white cardamom, 20 parts of corydalis, 20 parts of ophiopogon, 10 parts of cyperus, 20 parts of forsythia, 20 parts of chicken's gizzard lining, 20 parts of angelica, 20 parts of isatis root, 3 parts of ginger, and 3 parts of jujube.

[0008] Furthermore, the pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer comprises the following raw materials in parts by weight: 15 parts of bupleurum, 15 parts of poria, 15 parts of scutellaria, 15 parts of white peony root, 10 parts of curcuma, 15 parts of gardenia, 10 parts of fructus aurantii, 15 parts of liushenqu, 10 parts of white cardamom, 15 parts of corydalis, 15 parts of ophiopogon, 10 parts of cyperus, 15 parts of forsythia, 15 parts of chicken's gizzard lining, 15 parts of angelica, 15 parts of isatis root, 1 part of ginger, and 1 part of jujube.

[0009] The above-mentioned pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer is prepared by mixing the extracts of the components and a pharmaceutically acceptable carrier into decoction, granules, powders, capsules, tablets, pills or oral solutions.

[0010] The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine composition. When the traditional Chinese medicine composition is a water decoction, the preparation method comprises the following steps: weighing the raw materials according to the ratio; adding the raw materials into 8-12 times the weight of water and soaking them for 30 minutes, then heating them to boiling and keeping them slightly boiling, and obtaining a first decoction and medicinal residues after separation; taking the medicinal residues obtained after the first decoction, adding water equivalent to 8-10 times the weight of the total mass of the raw materials, heating them to boiling and keeping them slightly boiling, and obtaining a second decoction and medicinal residues after separation; and combining the first decoction and the second decoction to obtain a water decoction.

[0011] The present invention also provides a method for preparing the above-mentioned traditional Chinese medicine composition. When the traditional Chinese medicine composition is in the form of a powder, the preparation method comprises the following steps: taking the above-mentioned drug combination by weight, crushing the powder, and simultaneously passing it through 10-mesh and 50-mesh sieves; continuing to crush the coarse particles that cannot pass through the 10-mesh sieve, and taking the powder between the 10-mesh and 50-mesh sieves; uniformly mixing the raw material powders, placing the mixture into a packaging bag, and sealing the bag. When needed, the powder can be taken directly with 150-200 ml of warm boiled water.

[0012] The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine composition. When the traditional Chinese medicine composition is in the form of pills, the preparation method comprises the following steps: taking the above-mentioned drug combination by weight, crushing, passing through 10-mesh and 50-mesh sieves, further crushing the coarse particles that cannot pass through the 10-mesh sieve, taking the powder between the 10-mesh sieve and the 50-mesh sieve, and drying in the sun; taking an appropriate amount of honey, slowly boiling over a low heat, stirring, removing impurities and foam on the surface, and when the temperature rises to 116°C to 119°C, mixing it with the drug powder (adding it in a ratio of 1:1.2-1.5), rolling it into pills, each pill weighing about 3g, and after drying the prepared honey pills at room temperature, sealing them in bags for storage. The pills are easy to take and have long-lasting medicinal effects.

[0013] Another object of the present invention is to provide a pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer and its use in medicines for treating chronic gastritis and gastroduodenal ulcer.

[0014] The main symptoms of chronic gastritis and gastroduodenal ulcer: persistent or recurrent epigastric pain (bloating, stabbing, dull pain, severe pain, and preference or refusal to press), abdominal distension, noisy and acid refutation, sighing, belching, poor appetite, dry mouth and bitter taste, and dry stool.

[0015] Secondary symptoms of chronic gastritis and gastroduodenal ulcer: impatience and irritability, dizziness or limb fatigue, irritability, constipation, preference for cold drinks, insomnia and nightmares, hot hands and feet, and light yellow urine.

[0016] In this formula, bupleurum, poria, angelica, white peony root, fructus aurantii, and cyperus rotundus serve as the main herbs to soothe the liver, invigorate the spleen, and regulate qi. Scutellaria baicalensis, curcuma, gardenia, forsythia, isatis root, and ophiopogon are used as assistant herbs to clear the stomach, relieve heat, and soothe the stomach. Corydalis yanhusuo, liushenqu, white cardamom, and chicken's gizzard lining are used as auxiliary herbs to regulate qi, stimulate the appetite, digest food, and resolve stagnation. Ginger and jujube are used to soothe the stomach and soothe the stomach. This formula has the effects of soothing the liver and regulating qi, clearing heat and soothing the stomach, invigorating the spleen and digesting food, and soothing the stomach and relieving pain.

[0017] Bupleurum chinense (DC) or Bupleurum corzonerifolium (Willid), both of the Apiaceae family, is a dried root. It enters the Liver and Gallbladder Meridians. Its properties are bitter and slightly cold. Its effects are: harmonizing the exterior and interior, soothing the liver, and promoting yang.

[0018] Scutellaria baicalensis is the dried root of Scutellaria baicalensis Georgi, a plant of the Lamiaceae family. It enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. Its properties are bitter and cold. Its effects include clearing heat and dampness, purging fire and detoxifying, stopping bleeding, and stabilizing pregnancy.

[0019] Poria cocos, derived from the dried sclerotia of the Polyporaceae fungus Poriacocos (Schw.) Wolf, enters the Heart, Lung, Spleen, and Kidney meridians. Its properties are sweet, mild, and neutral. Its effects include promoting diuresis and dispelling dampness, strengthening the spleen, and calming the mind.

[0020] Curcuma zedoaria is the dried root tuber of Curcuma wenyujin (YH Chen et C. Ling), Curcuma longa L., Curcuma kwangsiensis (SG Lee et CF Liang), or Curcumaphaeocaulis Val. (all from the Zingiberaceae family). It enters the Liver, Heart, and Lung meridians. Its properties are pungent, bitter, and cold. Its effects include promoting qi and removing blood stasis, clearing the heart and relieving depression, and promoting bile secretion and alleviating jaundice.

[0021] Cyperus rotundus L. is the dried rhizome of the Cyperus rotundus L. plant of the Cyperaceae family. It enters the Liver, Spleen, and Triple Burner meridians. Its properties and flavors are pungent, slightly bitter, slightly sweet, and neutral. Its effects include promoting qi circulation, relieving depression, regulating menstruation, and relieving pain.

[0022] Gardenia jasminoides Ellis is the dried, mature fruit of the Rubiaceae plant. It enters the Heart, Lung, and Triple Burner meridians. Its properties are bitter and cold. Its effects include purging heat and relieving restlessness, clearing heat and promoting urination, cooling the blood and detoxifying.

[0023] Forsythia suspensa (Thunb.) Vahl, a plant of the Oleaceae family, is a dried fruit. It enters the Lung, Heart, and Small Intestine meridians. Its properties are bitter and slightly cold. Its effects include clearing heat and detoxifying, reducing swelling and dispersing stagnation.

[0024] Isatis root is the dried root of Isatis indigotica Fort., a plant in the cruciferous family. It enters the heart and stomach meridians.

[0025] Nature and flavor: bitter, cold. Efficacy: clears heat and detoxifies, cools blood and relieves sore throat.

[0026] Ophiopogon japonicus (Ophiopogon japonicus) is the dried root tuber of the Liliaceae plant Ophiopogon japonicus (Thunb.) Ker-Gawl. It enters the Heart, Lung, and Stomach meridians. Its properties are sweet, slightly bitter, and slightly cold. Its effects include nourishing Yin, promoting fluid production, moistening the lungs, and clearing the heart.

[0027] Corydalis yanhusuo (Yanhusuo) is the dried tuber of Corydalis yanhusuo (T. Wang) in the Poppy family. It enters the Liver and Spleen meridians. Its properties are pungent, bitter, and warm. Its effects include promoting blood circulation, promoting Qi, and relieving pain.

[0028] Citrus aurantium (Fructus Aurantium) is the dried, immature fruit of Citrus aurantium L. and its cultivated varieties, both of the Rutaceae family. It enters the spleen and stomach meridians. Its properties are bitter, pungent, sour, and warming. Its efficacy is to regulate qi, relieve fullness, and relieve stagnation and distension.

[0029] Liushenqu is a fermented product made from flour, bran, and other medicinal ingredients. Its properties are sweet, pungent, and warm. Its benefits include aiding digestion and strengthening the stomach.

[0030] White cardamom is the dried mature fruit of Amomum kravanh Pierre ex Gagnep (Zingiberaceae), or Amomum compactum Soland.ex Maton (Javan white cardamom). It enters the Lung, Spleen, and Stomach meridians. Its properties are pungent and warming. Its effects include dispelling dampness, promoting qi and warming the middle, and stimulating appetite and aiding digestion.

[0031] Chicken's gizzard lining is the dried inner wall of the gizzard lining of Gallus gallus domesticus Brisson, a member of the Phasianidae family. It enters the spleen, stomach, small intestine, and bladder meridians. Nature and flavor: sweet, neutral. Efficacy: tonifies the stomach and aids digestion, astringes semen, and stops nocturnal emission.

[0032] Ginger is the fresh rhizome of Zingiber officinale Rosc., a plant of the Zingiberaceae family. It enters the lung, spleen, and stomach meridians.

[0033] Nature and flavor: pungent, slightly warm. Efficacy: dispels cold, warms the middle and stops vomiting, resolves phlegm and relieves cough.

[0034] Jujube (Ziziphus jujuba) is the dried, mature fruit of Ziziphus jujuba Mill. var. inermis (Bunge) Rehd., a plant of the Rhamnaceae family. It enters the spleen and stomach meridians. Its properties are sweet and warm. Its effects are tonifying the middle qi, nourishing the blood, and calming the mind.

[0035] Currently, there are many kinds of Chinese medicine preparations for treating chronic gastritis and gastroduodenal ulcer, and the clinical effect is limited. The Chinese medicine composition proposed by the present invention and its preparation method are the summary of many years of clinical experience of traditional Chinese medicine, which can not only significantly improve the symptoms of chronic gastritis, gastroduodenal ulcer, epigastric pain, noisy acid reflux, heartburn, fullness in the stomach, poor appetite, belching, and bitter taste in the mouth. Simultaneously, the invention can be used regardless of whether it is caused by exogenous pathogens, food and medicine, emotions or weak spleen and stomach of the body, and the clinical effective rate is high, and it works quickly without obvious toxic and side effects. DETAILED DESCRIPTION

[0036] The present invention is further illustrated below with reference to specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not limited to the scope of the present invention. Various equivalent modifications of the present invention made by those skilled in the art fall within the scope defined by the claims appended to this application.

[0037] A pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer comprises the following raw materials in parts by weight: 15-30 parts of bupleurum, 15-30 parts of poria, 15-30 parts of scutellaria, 15-30 parts of white peony root, 10-20 parts of turmeric, 15-30 parts of gardenia, 10-20 parts of fructus aurantii, 15-30 parts of liushenqu, 10-20 parts of white cardamom, 10-20 parts of corydalis, 15-30 parts of ophiopogon, 10-15 parts of cyperus, 15-30 parts of forsythia, 15-30 parts of chicken's gizzard lining, 15-30 parts of angelica, 15-30 parts of isatis root, 1-3 parts of ginger, and 1-3 parts of jujube.

[0038] A pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer comprises the following raw materials in parts by weight: 20 parts of bupleurum, 20 parts of poria, 20 parts of scutellaria, 20 parts of white peony root, 10 parts of turmeric, 20 parts of gardenia, 10 parts of fructus aurantii, 20 parts of liushenqu, 10 parts of white cardamom, 20 parts of corydalis, 20 parts of ophiopogon, 10 parts of cyperus, 20 parts of forsythia, 20 parts of chicken's gizzard lining, 20 parts of angelica, 20 parts of isatis root, 3 parts of ginger, and 3 parts of jujube.

[0039] A pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer comprises the following raw materials in parts by weight: 15 parts of bupleurum, 15 parts of poria, 15 parts of scutellaria, 15 parts of white peony root, 10 parts of curcuma, 15 parts of gardenia, 10 parts of fructus aurantii, 15 parts of liushenqu, 10 parts of white cardamom, 15 parts of corydalis, 15 parts of ophiopogon, 10 parts of cyperus, 15 parts of forsythia, 15 parts of chicken's gizzard lining, 15 parts of angelica, 15 parts of isatis root, 1 part of ginger, and 1 part of jujube.

[0040] The pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcers is prepared by combining the extracts of the various components with a pharmaceutically acceptable carrier into a decoction, granules, powder, capsule, tablet, pill, or oral solution. In some embodiments, the Chinese medicine composition can be in the form of a decoction, pill, paste, tablet, capsule, granules, powder, or the like. The Chinese medicine composition of the present invention is often taken in the form of a decoction, which is convenient for patients to prepare and take.

[0041] The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine composition. When the traditional Chinese medicine composition is a water decoction, the preparation method comprises the following steps: weighing the raw materials according to the ratio; adding the raw materials into 8-12 times the weight of water and soaking them for 30 minutes, then heating them to boiling and keeping them slightly boiling, and obtaining a first decoction and medicinal residues after separation; taking the medicinal residues obtained after the first decoction, adding water equivalent to 8-10 times the weight of the total mass of the raw materials, heating them to boiling and keeping them slightly boiling, and obtaining a second decoction and medicinal residues after separation; and combining the first decoction and the second decoction to obtain a water decoction.

[0042] The present invention also provides a method for preparing the above-mentioned traditional Chinese medicine composition. When the traditional Chinese medicine composition is in the form of a powder, the preparation method comprises the following steps: taking the above-mentioned drug combination by weight, crushing the powder, and simultaneously passing it through 10-mesh and 50-mesh sieves; continuing to crush the coarse particles that cannot pass through the 10-mesh sieve, and taking the powder between the 10-mesh and 50-mesh sieves; uniformly mixing the raw material powders, placing the mixture into a packaging bag, and sealing the bag. When needed, the powder can be taken directly with 150-200 ml of warm boiled water.

[0043] The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine composition. When the traditional Chinese medicine composition is in the form of pills, the preparation method comprises the following steps: taking the above-mentioned drug combination by weight, crushing, passing through 10-mesh and 50-mesh sieves, further crushing the coarse particles that cannot pass through the 10-mesh sieve, taking the powder between the 10-mesh sieve and the 50-mesh sieve, and drying in the sun; taking an appropriate amount of honey, slowly boiling over a low heat, stirring, removing impurities and foam on the surface, and when the temperature rises to 116°C to 119°C, mixing it with the drug powder (adding it in a ratio of 1:1.2-1.5), rolling it into pills, each pill weighing about 3g, and after drying the prepared honey pills at room temperature, sealing them in bags for storage. The pills are easy to take and have long-lasting medicinal effects.

[0044] Example 1: Preparation of water decoction of Chinese medicine composition

[0045] Weigh the following medicinal materials by weight: 30 parts of bupleurum, 30 parts of poria, 30 parts of scutellaria, 30 parts of white peony root, 20 parts of curcuma, 30 parts of gardenia, 20 parts of fructus aurantii, 30 parts of liushenqu, 20 parts of white cardamom, 20 parts of yanhusuo, 30 parts of ophiopogon, 15 parts of cyperus, 30 parts of forsythia, 30 parts of chicken gizzard lining, 30 parts of angelica, 30 parts of isatis root, 3 parts of ginger, and 3 parts of jujube.

[0046] The raw materials are added to 8-12 times the weight of water and soaked for 30 minutes, then heated to boiling and kept slightly boiling, and separated to obtain a first decoction and medicinal residues; the medicinal residues obtained after the first decoction are added with 8-10 times the weight of water equivalent to the total mass of the raw materials, heated to boiling and kept slightly boiling, and separated to obtain a second decoction and medicinal residues; the first decoction and the second decoction are combined to obtain a water decoction of the traditional Chinese medicine composition of the present invention.

[0047] Example 2: Preparation of powder of Chinese medicine composition

[0048] Weigh the following medicinal materials by weight: 30 parts of bupleurum, 30 parts of poria, 30 parts of scutellaria, 30 parts of white peony root, 20 parts of curcuma, 30 parts of gardenia, 20 parts of fructus aurantii, 30 parts of liushenqu, 20 parts of white cardamom, 20 parts of yanhusuo, 30 parts of ophiopogon, 15 parts of cyperus, 30 parts of forsythia, 30 parts of chicken gizzard lining, 30 parts of angelica, 30 parts of isatis root, 3 parts of ginger, and 3 parts of jujube.

[0049] Take the above drug combination, crush it, and pass it through both 10-mesh and 50-mesh sieves. Continue crushing the coarse particles that cannot pass through the 10-mesh sieve, and take the powder between the 10-mesh and 50-mesh sieves. Mix all the raw material powders evenly, place them into a packaging bag, and seal it. When needed, take the powder directly with 150-200 ml of warm water.

[0050] Example 3: Preparation of pills of Chinese medicine composition

[0051] Weigh the following medicinal materials by weight: 30 parts of bupleurum, 30 parts of poria, 30 parts of scutellaria, 30 parts of white peony root, 20 parts of curcuma, 30 parts of gardenia, 20 parts of fructus aurantii, 30 parts of liushenqu, 20 parts of white cardamom, 20 parts of yanhusuo, 30 parts of ophiopogon, 15 parts of cyperus, 30 parts of forsythia, 30 parts of chicken gizzard lining, 30 parts of angelica, 30 parts of isatis root, 3 parts of ginger, and 3 parts of jujube.

[0052] The above drug combination is taken, crushed, and passed through 10-mesh and 50-mesh sieves. The coarse particles that cannot pass through the 10-mesh sieve are further crushed, and the powder located between the 10-mesh sieve and the 50-mesh sieve is taken and dried in the sun. An appropriate amount of honey is taken, slowly simmered over a low heat, stirred, and impurities and foam on the surface are removed. When the temperature rises to 116°C to 119°C, the mixture is mixed with the drug powder (added in a ratio of 1:1.2 to 1.5), and rolled into pills. Each pill is about 3g. The prepared honey pills are dried at room temperature and then packaged in sealed bags for storage. The pills are easy to take and have long-lasting efficacy.

[0053] Case 1

[0054] Zheng, female, 26 years old, suffered from stomach pain, especially when hungry, heartburn, acid reflux, and belching. She was diagnosed with chronic gastritis with duodenal ulcer, and the above symptoms recurred. After taking the formula of Example 1, the symptoms disappeared. Gastroscopy showed that the inflammation was significantly improved, the ulcer healed, and there was no recurrence.

[0055] Case 2

[0056] Zhang, male, 39 years old, suffered from stomachache, acid reflux, noisy mouth, bitter taste in the mouth, dry mouth, poor appetite, and limb weakness. He was diagnosed with chronic atrophic gastritis and gastroesophageal reflux. After taking the formula of Example 1, the symptoms disappeared.

[0057] Case 3

[0058] Gong, male, 45 years old, suffered from epigastric pain, intermittent pain, abdominal distension, and poor appetite, and was diagnosed with chronic atrophic gastritis. After taking the formula of Example 1, the symptoms disappeared.

[0059] Case 4

[0060] Mr. Liu, male, 33 years old, suffered from dull pain in the upper abdomen, acid reflux, and belching, and was diagnosed with chronic atrophic gastritis and antral ulcer. After taking the formula of Example 1, the symptoms disappeared, and the ulcer healed after gastroscopy.

[0061] Clinical efficacy verification:

[0062] A total of 144 patients who were diagnosed with chronic gastritis and gastroduodenal ulcer and treated with the present invention were selected from the outpatient clinic from January 2018 to August 2023, including 86 male patients and 58 female patients; 79 patients had chronic gastritis and 65 patients had gastroduodenal ulcer.

[0063] The above-mentioned patient adopts the Chinese medicine composition of Example 1: 30g of Bupleurum, 30g of Poria, 30g of Scutellaria, 30g of White Peony, 20g of Curcuma, 30g of Gardenia, 20g of Citrus aurantium, 30g of Liushenqu, 20g of White Cardamom, 20g of Corydalis, 30g of Radix Ophiopogonis, 15g of Cyperus, 30g of Forsythia, 30g of Gallus gallus, 30g of Angelica, 30g of Radix Isatidis, 3 slices of ginger, and 3 jujubes. The administration method is: decoction in water, twice a day, 200ml each time, taken warm half an hour before meals, and a treatment cycle of 7 to 14 days.

[0064] Criteria for judging efficacy:

[0065] According to the improvement effect of clinical symptoms, it is divided into four levels: markedly effective, effective, ineffective, and cured.

[0066] Efficacy index = (score before treatment - score after treatment) / score before treatment × 100%.

[0067] Clinical cure: clinical symptoms and signs disappear, efficacy index ≥ 90%;

[0068] Markedly effective: clinical symptoms and signs are significantly improved, with an efficacy index of 70% ≤ < 90%;

[0069] Effective: clinical symptoms and signs improved, 30% ≤ efficacy index < 70%;

[0070] Ineffective: clinical symptoms and signs remain unchanged or worsen, and the efficacy index is <30%.

[0071] Observation indicators:

[0072] Symptom observation: Changes in the main symptoms of the observed cases before and after treatment were observed and recorded. Symptom records were expressed using a graded scoring method: severe (3 points), moderate (2 points), mild (1 point), and no symptoms (0). Score was given for stomach pain, acid reflux, heartburn, belching, poor appetite, dry mouth and bitter taste, dry stool, impatience and irritability, limb fatigue, constipation, and light yellow urine. The sum of the above symptoms was the symptom score.

[0073] Electronic gastroscopy: Gastroscopy was performed on all cases within 1 to 2 weeks before and after treatment and the records were kept.

[0074] Observations:

[0075] The 144 patients in this example were followed up after treatment according to the course of treatment. Among them, 107 were clinically cured, 32 were effective, and 5 were significantly effective; the effective rate was 100%, and the therapeutic effect was significant.

[0076] The results show that:

[0077] The present invention has good clinical therapeutic effects on chronic gastritis, gastric ulcer and duodenal ulcer without causing obvious adverse reactions.

Claims

1. A pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer, characterized in that: The invention is prepared from the following raw materials in parts by weight: 15-30 parts of bupleurum, 15-30 parts of poria, 15-30 parts of scutellaria, 15-30 parts of white peony root, 10-20 parts of turmeric, 15-30 parts of gardenia, 10-20 parts of fructus aurantii, 15-30 parts of liushenqu, 10-20 parts of white cardamom, 10-20 parts of corydalis, 15-30 parts of ophiopogon, 10-15 parts of cyperus, 15-30 parts of forsythia, 15-30 parts of chicken gizzard lining, 15-30 parts of angelica, 15-30 parts of isatis root, 1-3 parts of ginger and 1-3 parts of jujube.

2. A pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer, characterized in that: The medicine is prepared from the following raw materials in parts by weight: 20 parts of bupleurum, 20 parts of poria, 20 parts of scutellaria, 20 parts of white peony root, 10 parts of turmeric, 20 parts of gardenia, 10 parts of fructus aurantii, 20 parts of liushenqu, 10 parts of white cardamom, 20 parts of corydalis, 20 parts of ophiopogon, 10 parts of cyperus, 20 parts of forsythia, 20 parts of chicken's gizzard lining, 20 parts of angelica, 20 parts of isatis root, 3 parts of ginger and 3 parts of jujube.

3. A pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer, characterized in that: The medicine is prepared from the following raw materials in parts by weight: 15 parts of bupleurum, 15 parts of poria, 15 parts of scutellaria, 15 parts of white peony root, 10 parts of curcuma, 15 parts of gardenia, 10 parts of fructus aurantii, 15 parts of liushenqu, 10 parts of white cardamom, 15 parts of corydalis, 15 parts of ophiopogon, 10 parts of cyperus, 15 parts of forsythia, 15 parts of chicken's gizzard lining, 15 parts of angelica, 15 parts of isatis root, 1 part of ginger, and 1 part of jujube.

4. The method for preparing the pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer according to any one of claims 1 to 3, characterized in that: The method comprises the following steps: weighing raw medicine according to a ratio; adding the raw medicine into water of 8-12 times the weight of the raw medicine and soaking the raw medicine for 30 minutes, then heating the raw medicine to boiling and keeping it slightly boiling, and obtaining a first decoction and medicinal residue after separation; taking the medicinal residue obtained after the first decoction, adding water equivalent to 8-10 times the weight of the total mass of the raw medicine, heating the raw medicine to boiling and keeping it slightly boiling, and obtaining a second decoction and medicinal residue after separation; and combining the first decoction and the second decoction to obtain a water decoction.

5. The method for preparing the pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer according to any one of claims 1 to 3, characterized in that: The method comprises the following steps: taking the above drug combination according to weight, crushing the drug combination, and passing the drug through 10-mesh and 50-mesh sieves at the same time; continuing to crush the coarse particles that cannot pass through the 10-mesh sieve, and taking the powder between the 10-mesh sieve and the 50-mesh sieve; uniformly mixing the raw material powders, putting the mixture into a packaging bag, and sealing the bag; and when the drug needs to be taken, directly taking the powder with 150-200 ml of warm boiled water.

6. The method for preparing the pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer according to any one of claims 1 to 3, characterized in that: The method comprises the following steps: taking the above drug combination by weight, crushing the mixture, passing the mixture through 10-mesh and 50-mesh sieves, further crushing the coarse particles that cannot pass through the 10-mesh sieve, taking the powder between the 10-mesh sieve and the 50-mesh sieve, and drying the mixture in the sun; taking an appropriate amount of honey, slowly boiling the mixture over a low heat, stirring the mixture, removing impurities and floating foam on the surface, and mixing the mixture with the drug powder when the temperature rises to 116°C to 119°C, adding the mixture in a ratio of 1:1.2-1.5, and rolling the mixture into pills, each pill weighing 3g.

7. The pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer according to any one of claims 1 to 3, characterized in that: The extracts of the raw materials and pharmaceutically acceptable carriers are prepared into decoctions, granules, powders, capsules, tablets, pills or oral solutions.

8. Use of the pharmaceutical composition for treating chronic gastritis and gastroduodenal ulcer according to any one of claims 1 to 3 in the preparation of medicaments for treating chronic gastritis and gastroduodenal ulcer.