A method for trifluoromethylation of olefins
By using hydroxylamine as an initiator and a trifluoromethylating agent in a solvent, the challenge of synthesizing Cvinyl-CF3 compounds via nonmetal-promoted olefin trifluoromethylation was solved, achieving efficient synthesis under mild conditions and improving reaction efficiency and yield.
CN117776862BActive Publication Date: 2026-05-26TSINGHUA UNIVERSITY
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Patent Information
- Application Number
- CN202311615342.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-11-29
- Publication Date
- 2026-05-26
- Estimated Expiration
- 2043-11-29
AI Technical Summary
Technical Problem
There are few existing methods for synthesizing Cvinyl-CF3 compounds by non-metal-promoted olefin trifluoromethylation, and it is difficult to achieve efficient synthesis under mild conditions.
Method used
Hydroxylamine is used as an initiator, and a trifluoromethylating agent is combined with an olefin to react in a solvent. The trifluoromethylation of the olefin is promoted by nonmetals under mild conditions, and the electron-donating ability of hydroxylamine is enhanced by using basic substances to promote the addition of trifluoromethyl radicals to the olefin.
Benefits of technology
Efficient trifluoromethylation of olefins was achieved under mild conditions, improving reaction yield and selectivity, simplifying the operation process, and reducing costs.
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Abstract
This invention discloses a method for the trifluoromethylation of olefins, comprising: reacting an olefin, a trifluoromethylating agent, and hydroxylamine in a solvent to obtain a trifluoromethylated olefin product. The method of this invention uses hydroxylamine as an initiator, and under mild conditions, nonmetals promote the trifluoromethylation of the olefin.
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