A method for the photocatalytic synthesis of trifluoromethylated polycyclic indole derivatives using visible light

By using visible light-catalyzed radical cyclization reaction of CF3Br with N-alkenylindole derivatives, trifluoromethylated polycyclic indole derivatives were successfully synthesized, solving the problems of high synthesis cost and difficult raw material acquisition in existing technologies, and realizing the efficient and low-cost synthesis of polycyclic indole derivatives.

CN122079999APending Publication Date: 2026-05-26NORTHWEST NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NORTHWEST NORMAL UNIVERSITY
Filing Date
2026-02-11
Publication Date
2026-05-26

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Abstract

This invention discloses a method for synthesizing trifluoromethylated polycyclic indole derivatives using visible light photocatalysis, belonging to the field of organic synthesis technology. This invention is the first to disclose a method for synthesizing trifluoromethylated polycyclic indole derivatives under visible light photocatalysis via CF3Br and... N This invention relates to a method for the one-step preparation of trifluoromethylated polycyclic indole derivatives, namely 2,3-dihydropyrrolo[1,2-a]indole and 5,6-dihydroindole[2,1-a]isoquinoline derivatives, through a free radical cyclization reaction of alkenyl indole derivatives. This invention is the first to use CF3Br as a trifluoromethylating agent, via CF3Br reacting with... N The radical cyclization reaction of α-alkenyl indole derivatives successfully constructed trifluoromethylated 2,3-dihydropyrrole[1,2-a]indole and 5,6-dihydroindole[2,1-a]isoquinoline derivatives. Compared with other trifluoromethylating reagents used in the prior art, CF3Br has the advantages of low cost, easy availability and high atom utilization. Compared with the existing synthetic methods, the method provided by this invention greatly reduces the synthesis cost and has a high possibility of large-scale production.
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