A composition comprising an extract of althea root containing drug

Abstract

The present application relates to a composition containing a hibiscus extract, comprising the following components by weight percentage: 0.5-5.0% of hibiscus extract, 0.5-5% of gray rock rose flower / leaf / stem extract, 1.0-10.0% of humectant, 2.0-10.0% of emollient, 1.0-5.0% of emulsifier, 0.1-5.0% of thickening agent, 0.02-1.0% of pH regulator, and the balance of water. The composition can remove the blockage and oil in the hair follicle, dredge the converging pores, promote the metabolism of the skin, make the skin smooth and delicate, improve the water-oil balance of the skin, resist bacteria and inflammation, improve the body's immunity, inhibit the growth of microorganisms, achieve the effects of moisturizing and oil control, soothing and repairing, and can be applied to the skin under the armpit to reduce the amount of sweat, reduce the odor and smell, and achieve the effects of antiperspirant and deodorant.

Description

Technical Field

[0001] This invention belongs to the field of daily cosmetics, and specifically relates to a composition containing a medicinal marshmallow root extract. Background Technology

[0002] Cosmetics are products used to enhance or alter the appearance, fragrance, or texture of the face or body. Many cosmetics are specifically designed for application to the face and body; they are often mixtures of compounds of natural origin, or they may be synthetic or artificial.

[0003] With socio-economic development and environmental degradation, young people today face various pressures. Staying up late, all-nighters, drinking alcohol, unhealthy diets, and prolonged use of mobile phones or other electronic devices, combined with external environmental and psychological factors, lead to a variety of skin problems. Dry, dehydrated skin, itching, redness, and a damaged skin barrier result in incomplete repair by the skin's own systems. Increased transepidermal water loss affects the cellular environment, causing sebum metabolism disorders, excessive sebum secretion, and excessive keratinization of hair follicles and sebaceous glands. This narrows and blocks the hair follicle openings, allowing microorganisms to proliferate and accumulate, leading to inflammation and ultimately skin problems such as acne and pimples.

[0004] Global warming and high summer temperatures increase perspiration, especially underarm sweating. This lack of ventilation allows sweat to ferment and produce odor molecules, causing embarrassment and discomfort for both the user and those around them. Many antiperspirant and deodorant products on the market are composed of mixtures of aluminum salts, zirconium salts, higher alcohols, volatile polysiloxanes, and fragrances. However, such compositions often feel sticky on the skin, form a non-breathable film after drying, are uncomfortable, and can be quite irritating. Their antiperspirant and deodorant effects are not long-lasting, and prolonged use may even lead to clogged sweat glands. Summary of the Invention

[0005] The technical problem to be solved by this invention is to provide a composition containing marshmallow root extract, which can remove blockages and oil from hair follicles, unclog and tighten pores, promote skin metabolism, and make the skin smooth and delicate; improve the skin's water-oil balance, have antibacterial and anti-inflammatory effects, enhance the body's own immunity, inhibit the growth of microorganisms, and achieve the effects of moisturizing, oil control, soothing and repairing; at the same time, it can be applied to condition the skin under the armpits, reduce the amount of sweat under the armpits, reduce odor and odor, and achieve the effects of antiperspirant and deodorant.

[0006] The technical solution adopted by the present invention to solve the above problems is as follows:

[0007] A composition containing a medicinal marshmallow root extract, comprising the following components by weight percentage:

[0008] Marshmallow root extract 0.5%–5.0%,

[0009] Extracts of Rosa grayish-white from flowers, leaves, and stems: 0.5%–5%.

[0010] Moisturizer 1.0%–10.0%,

[0011] Moisturizing oils 2.0%–10.0%,

[0012] Emulsifier 1.0%–5.0%,

[0013] Thickener 0.1%–5.0%,

[0014] pH adjuster 0.02%–1.0%,

[0015] And the remaining water.

[0016] Furthermore, the preparation method of the marshmallow root extract includes the following steps:

[0017] S1. After freezing the roots of the medicinal marshmallow at low temperature, the roots are crushed to obtain medicinal marshmallow root powder;

[0018] S2. Add the root powder of Alpinia oxyphylla, solvent, and compound biological enzyme to the reactor, stir evenly, raise the temperature to 65℃~70℃, and enzymatically hydrolyze for 2~3 hours;

[0019] S3. After enzymatic hydrolysis, rapidly heat up to inactivate the enzyme, then cool down to 45℃~50℃, add extraction solvent and perform continuous countercurrent ultrasonic extraction for 20min~50min.

[0020] S4. After ultrasonic extraction, a separation solution is obtained. The separation solution is then decolorized to obtain the extract of marshmallow root.

[0021] Furthermore, in step S1, after freezing the root of the medicinal marshmallow at low temperature, it is pulverized into medicinal marshmallow root powder of 200-300 mesh.

[0022] Furthermore, in step S2, the weight ratio of the solvent to the marshmallow root powder is 1:10.

[0023] Furthermore, in step S2, the solvent is a mixture of 30% dipropylene glycol and 70% water.

[0024] Furthermore, in step S2, the composite bio-enzyme is composed of trypsin, cellulase, and pectinase.

[0025] Furthermore, in step S2, the composite bio-enzyme is composed of trypsin, cellulase, and pectinase in a weight ratio of 1:2:1.

[0026] Furthermore, in step S3, after enzymatic hydrolysis, the temperature is rapidly increased to 100°C for rapid inactivation, and after 1 minute of inactivation, the temperature is reduced to 45°C to 50°C.

[0027] Furthermore, in step S3, the extraction solvent is at least one of water, ethanol, and 1,3-butanediol.

[0028] Furthermore, the moisturizer is at least one selected from glycerin, propylene glycol, butylene glycol, dipropylene glycol, 1,2-hexanediol, 1,2-pentanediol, sorbitol, β-glucan, saccharide isomers, diglycerides, polyethylene glycol-32, D-panthenol, betaine, trehalose, fructooligosaccharides, sodium polyglutamate, and sodium hyaluronate.

[0029] Furthermore, the moisturizing oil is at least one of plant-based oils, mineral oils, and fatty acid esters.

[0030] Furthermore, the vegetable oil is at least one of olive oil, corn oil, wheat germ oil, almond oil, coconut oil, avocado oil, macadamia seed oil, evening primrose oil, cocoa seed oil, jojoba seed oil, camellia seed oil, oat kernel oil, and shea butter.

[0031] Preferably, the vegetable oil is at least one of shea butter, jojoba seed oil, and avocado oil.

[0032] Furthermore, the mineral oil is at least one of petrolatum, 15# white oil, 25# white oil, 26# white oil, isododecane, isohexadecane, and isoeicosane.

[0033] Preferably, the mineral oil is at least one of 15# white oil and isododecane.

[0034] Furthermore, the fatty acid ester is at least one of isopropyl myristate, isopropyl palmitate, isopropyl stearate, caprylic / capric triglyceride, capric triglyceride, and octyl palmitate.

[0035] Furthermore, the emulsifier is at least one selected from glyceryl stearate, PEG-100 stearate, cetearyl glucoside, coconut glucoside, C12-C20 alkyl glucoside, eicosyl glucoside, glyceryl stearate, stearyl alcohol ether-20, glyceryl stearate, PEG-75 stearate, polyglyceryl-6 stearate, polyglyceryl-10 stearate, polyglyceryl-10 oleate, polyglyceryl-10 dipalmitate, and hydrogenated lecithin.

[0036] Furthermore, the thickener is at least one of the following: acrylate / C10-30 alkanol acrylate crosspolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, xanthan gum, and carbomer.

[0037] Furthermore, the pH adjuster is at least one of sodium hydroxide, potassium hydroxide, triethanolamine, and arginine.

[0038] Furthermore, the composition containing the medicinal marshmallow root extract further includes at least one of the following components by weight percentage:

[0039] Auxiliary emulsifier 0.01%–5.0%,

[0040] Chelating agent 0.005%–0.2%,

[0041] Preservatives: 0.01%–1%.

[0042] Furthermore, the auxiliary emulsifier is at least one of cetyl alcohol, stearyl alcohol, and cetearyl alcohol.

[0043] Furthermore, the chelating agent is at least one of disodium EDTA, tetrasodium EDTA, and inositol hexaphosphate.

[0044] Furthermore, the preservative is at least one of phenoxyethanol, chlorphenesin, potassium sorbate, and sodium benzoate.

[0045] The present invention has the following beneficial effects:

[0046] This invention employs low-temperature freeze-pulverization and a specific ratio of compound bio-enzyme catalysis combined with ultrasonic extraction technology to obtain a marshmallow root extract containing higher levels of phytosterols, long-chain sugars, quercetin, and other flavonoids with various biological activities. This extract can better stimulate the skin's own moisturizing mechanism, maintain optimal hydration and water retention in the dermis and epidermis, reduce skin moisture loss, thereby improving dry skin, maintaining the skin's water-oil balance, effectively inhibiting skin inflammation, and maximizing its efficacy.

[0047] This invention provides a composition containing marshmallow root extract, which can remove blockages and oil from hair follicles, unclog and tighten pores, promote skin metabolism, and make the skin smooth and delicate; improve the skin's water-oil balance, have antibacterial and anti-inflammatory effects, enhance the body's own immunity, inhibit microbial growth, and achieve moisturizing, oil-controlling, soothing and repairing effects; at the same time, it can be applied to condition the underarm skin, reduce underarm sweating, reduce odor, and achieve antiperspirant and deodorizing effects. Attached Figure Description

[0048] Figure 1 Comparison of facial pores collected from volunteer 1 before and after 7 days of continuous use of the composition of Example 1;

[0049] Figure 2 Comparison of facial pores collected from volunteer 2 before and after 7 days of continuous use of the composition of Example 1;

[0050] Figure 3 Comparison of facial pores collected from volunteer 3 before and after 7 days of continuous use of the composition of Example 1. Detailed Implementation

[0051] The present invention will now be described in detail with reference to the embodiments. These embodiments are merely preferred implementations of the present invention and are not intended to limit the invention. Unless otherwise specified, the methods involved in this invention are methods commonly used in the art; the reagents involved, unless otherwise specified, can be obtained from ordinary commercial channels.

[0052] The preparation of a root extract of the medicinal herb *Haloxylon ammodendron* includes the following steps:

[0053] S1. After freezing the roots of the medicinal marshmallow at low temperature, pulverize them into medicinal marshmallow root powder of 200-300 mesh;

[0054] S2. Add the root powder of Alpinia oxyphylla, 30% dipropylene glycol and compound biological enzyme to the reactor, stir evenly, raise the temperature to 65℃~70℃, and enzymatically hydrolyze for 2~3 hours;

[0055] S3. After enzymatic hydrolysis, rapidly heat to 100℃ for rapid inactivation, cool to 45℃~50℃ after 1 min of inactivation, add ethanol and perform continuous countercurrent ultrasonic extraction for 20 min~50 min.

[0056] S4. After ultrasonic extraction, a separation solution is obtained. The separation solution is then decolorized to obtain the extract of marshmallow root.

[0057] Specifically, in step S2, the weight ratio of the solvent to the marshmallow root powder is 1:10.

[0058] Specifically, in step S2, the composite bio-enzyme is composed of trypsin, cellulase, and pectinase in a weight ratio of 1:2:1.

[0059] The prepared marshmallow root extract was used to prepare the compositions of the examples and comparative examples, wherein the preparation methods of the compositions of the examples and comparative examples included the following steps:

[0060] A. Add humectant, chelating agent, thickener and water to a reactor, heat to 80℃~85℃ and stir evenly, then keep warm to obtain phase A;

[0061] B. Add emulsifier, moisturizing oil, and auxiliary emulsifier to another reactor, heat to 80℃~85℃ and stir evenly to obtain phase B;

[0062] C. Add phase B to phase A for homogenization and emulsification, cool to 40℃~45℃, add marshmallow root extract, Rosa balsamina flower / leaf / stem extract, pH adjuster, preservative, and stir well.

[0063] D. Continue cooling to 35℃~38℃ to obtain the composition.

[0064] Specifically, the moisturizers are glycerin and sodium hyaluronate.

[0065] Specifically, the chelating agent is disodium EDTA.

[0066] Specifically, the thickener is carbomer.

[0067] Specifically, the emulsifier is cetearyl glucoside.

[0068] Specifically, the moisturizing oil is caprylic / capric triglyceride.

[0069] Specifically, the auxiliary emulsifier is cetearyl alcohol.

[0070] Specifically, the pH adjuster is sodium hydroxide.

[0071] Specifically, the specific amounts of each component in the embodiments and comparative compositions are shown in Table 1 below, in units of weight percentage.

[0072] Table 1:

[0073] Raw material name Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Hibiscus sabdariffa L. extract 2 3 / 2 / Rosa rugosa Thunb. flower / leaf / stem extract 1 2 / / 1 Glycerin 5 8 5 5 5 Sodium hyaluronate 0.05 0.05 0.05 0.05 0.05 Cetostearyl glucoside 3 2 3 3 3 Carbomer 0.6 0.7 0.6 0.6 0.6 Caprylic / capric triglyceride 7 6 7 7 7 Cetostearyl alcohol 1.5 1.5 1.5 1.5 1.5 Disodium EDTA 0.05 0.03 0.05 0.05 0.05 Sodium hydroxide 0.06 0.06 0.06 0.06 0.06 Preservative 0.8 0.8 0.8 0.8 0.8 Deionized water To 100 To 100 To 100 To 100 To 100

[0074] The efficacy of the compositions in the above embodiments and comparative examples was evaluated. The specific efficacy evaluated included stratum corneum moisture content, skin oil content, pore image acquisition comparison, sensory score of underarm odor, and change rate of underarm sweating.

[0075] According to the Guidelines for Evaluating the Moisturizing Efficacy of Cosmetics QB / T 4256-2011 and R-WI-242 Efficacy Evaluation of Oil-Control Products—Human Trial Method, the following tests were conducted:

[0076] 1. The moisture content of the stratum corneum and the oil content of the skin:

[0077] Fifty volunteers were selected and divided into five groups of ten. After washing their foreheads with water, specific locations were marked on both sides of their foreheads. Volunteers sat quietly for 30 minutes in a constant temperature and humidity environment, and the initial moisture content of the stratum corneum and the sebum content of the skin were measured. All five groups of volunteers applied the compositions of the example and the comparative example to the right side of their foreheads, respectively. Six hours later, they sat quietly again, and the moisture content of the stratum corneum and the sebum content of the skin were measured again. The changes in the moisture content of the stratum corneum and the sebum content of the skin before and after using the compositions of the example and the comparative example are shown in Table 2.

[0078] Table 2:

[0079] Index Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Stratum corneum moisture content change rate (%) 35.4 43.2 10.2 26.1 15.7 Sebum content change rate (%) -15.5 -19.3 3.8 -7.9 -5.6

[0080] As shown in Table 2, after using the compositions of the examples and comparative examples once, the moisture content of the stratum corneum increased significantly 6 hours later. Compared with comparative examples 1-3, the increase in moisture content of the stratum corneum in examples 1-2 of the present invention was larger, while the oil content was significantly reduced. This indicates that both the root extract of Marshmallow and the flower / leaf / stem extract of Rosa davidii can enhance the skin's moisturizing and oil-controlling effects. However, compared with using one of the extracts alone, the simultaneous use of the root extract of Marshmallow and the flower / leaf / stem extract of Rosa davidii has a synergistic effect, resulting in better moisturizing and oil-controlling effects.

[0081] 2. Comparison of pore images:

[0082] Volunteers uniformly cleaned their faces with water, patted them dry with tissues, and sat quietly for 30 minutes in a room meeting environmental requirements, during which time they could not drink water or beverages. The test area was exposed and placed in a test position, remaining relaxed. Facial images were captured using a VisioFace 1000D facial image analyzer before the application of the composition. The composition of Example 1 was applied to the face twice a day, morning and evening, and another image was captured 7 days later. The image acquisition results are as follows: Figure 1 , Figure 2 , Figure 3 As shown.

[0083] Figure 1 Comparison of facial pores collected from volunteer 1 before and after 7 days of continuous use of the composition of Example 1; the upper image is a facial pore collection image of volunteer 1 before using the composition of Example 1, and the lower image is a facial pore collection image of volunteer 1 after 7 days of continuous use of the composition of Example 1.

[0084] Figure 2 Comparison of facial pores collected from volunteer 2 before and after 7 days of continuous use of the composition of Example 1; the upper image is a facial pore collection image of volunteer 2 before using the composition of Example 1, and the lower image is a facial pore collection image of volunteer 2 after 7 days of continuous use of the composition of Example 1.

[0085] Figure 3 Images of facial pores collected from volunteer 3 before and after 7 days of continuous use of the composition of Example 1; the upper image is an image of facial pores collected from volunteer 3 before using the composition of Example 1, and the lower image is an image of facial pores collected from volunteer 3 after 7 days of continuous use of the composition of Example 1.

[0086] according to Figures 1 to 3 It is known that the root extract of Marshmallow combined with the flower / leaf / stem extract of Rosa rugosa 'Grey White' has a synergistic effect, which can not only moisturize and control oil, but also shrink pores, reduce the number and area of ​​pores, make the skin smoother and more delicate, and brighten the complexion.

[0087] 3. Sensory score of underarm odor and rate of change in underarm sweating:

[0088] Fifty volunteers meeting the criteria for bromhidrosis were selected and divided into five groups of ten. Each group used the compositions prepared in the above-described examples and comparative examples. The compositions were applied evenly to the left armpit twice daily, morning and evening. The right armpit was not treated. After 14 days of use, the subjects washed their armpits with a special unscented shower gel the night before the test. The next day, in the efficacy laboratory, after continuing to use the composition on the left armpit, a special pad, pre-weighed on a balance scale, was attached to the armpit of a cotton tight-fitting garment. The subjects remained in a hot room (38℃, 30-40% relative humidity) for one hour. The pad was then removed, and its weight after absorbing sweat was immediately measured. The amount of sweat was determined by comparing the weight of the pad before and after sweating. The pad was then sealed in a bag by a designated person.

[0089] The odor sensory evaluation was conducted according to the Wild II rating scale, a standard for odor intensity scoring. The Wild II rating scale standard is shown in Table 3 below.

[0090] The sensory scores of underarm odor and the rate of change in underarm sweating before and after using the compositions of the examples and comparative examples are shown in Table 4.

[0091] Table 3:

[0092] Score Degree of malodor Score Degree of malodor 0 points No odor 6 points Slightly strong odor 1 point Threshold odor 7 points Moderately strong odor 2 points Very weak odor 8 points Strong odor 3 points Weak odor 9 points Very strong odor 4 points Weak to moderate odor 10 points Extremely strong odor 5 points Moderate odor - -

[0093] Table 4:

[0094] Index Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Sweating change rate (%) (left side application area) 9.1 7.4 20.5 15.6 16.9 Sweating change rate (%) (right side blank area) 22 22.1 22 21.4 22.2 Left side application vs. right side inhibition of sweating rate (%) -58.6 -66.5 -6.8 -27.1 -23.9 Odor score (left side application area) 3.7 2.8 6.9 4.9 5.1 Odor score (right side blank area) 7.8 7.5 7.2 6.5 6.8 Left side application vs. right side inhibition of odor rate (%) -52.6 -62.7 -4.2 -24.6 -25

[0095] As shown in Table 4, the combination of marshmallow root extract and Rosa rugosa flower / leaf / stem extract exhibits significant effects in inhibiting sweating and odor when applied to the composition.

[0096] The efficacy evaluation results of the above embodiments and comparative examples show that the composition containing marshmallow root extract provided by the present invention can remove blockages and oil from hair follicles, unclog and tighten pores, promote skin metabolism, and make the skin smooth and delicate; improve the skin's water-oil balance, have antibacterial and anti-inflammatory effects, enhance the body's own immunity, inhibit microbial growth, and achieve the effects of moisturizing, oil control, soothing and repairing; at the same time, it can be applied to condition the underarm skin, reduce underarm sweating, reduce odor, and achieve the effects of antiperspirant and deodorant.

[0097] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0098] It should also be noted that the various specific technical features described in the above embodiments can be combined in any suitable manner without contradiction. To avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

[0099] Furthermore, various different embodiments of the present invention can be combined in any way, as long as they do not violate the spirit of the present invention, they should also be regarded as the content disclosed by the present invention.

Claims

1. A composition containing a medicinal marshmallow root extract, characterized in that, Includes the following components by weight percentage: Marshmallow root extract 0.5%–5.0%, Extracts of Rosa grayish-white from flowers, leaves, and stems: 0.5%–5%. Moisturizer 1.0%~10.0%, Moisturizing oils 2.0%–10.0%, Emulsifier 1.0%–5.0%, Thickener 0.1%–5.0%, pH adjuster 0.02%~1.0%, And the remaining water; The preparation method of the marshmallow root extract includes the following steps: S1. After freezing the roots of the medicinal marshmallow at low temperature, the roots are crushed to obtain medicinal marshmallow root powder; S2. Add the root powder of Alpinia oxyphylla, solvent, and compound biological enzyme to the reactor. The compound biological enzyme is composed of trypsin, cellulase and pectinase in a weight ratio of 1:2:

1. Stir evenly, heat to 65℃~70℃, and enzymatically hydrolyze for 2~3 hours. S3. After enzymatic hydrolysis, rapidly heat up to inactivate the enzyme, then cool down to 45℃~50℃, add extraction solvent and perform continuous countercurrent ultrasonic extraction for 20min~50min. S4. After ultrasonic extraction, a separation solution is obtained. The separation solution is then decolorized to obtain the extract of marshmallow root.

2. The composition containing the medicinal marshmallow root extract according to claim 1, characterized in that, The moisturizer is at least one of the following: glycerin, propylene glycol, butylene glycol, dipropylene glycol, 1,2-hexanediol, 1,2-pentanediol, sorbitol, β-glucan, saccharide isomers, diglycerides, polyethylene glycol-32, D-panthenol, betaine, trehalose, fructooligosaccharides, sodium polyglutamate, and sodium hyaluronate.

3. The composition containing the medicinal marshmallow root extract according to claim 1, characterized in that, The moisturizing oil is at least one of plant-based oils, mineral oils, and fatty acid esters.

4. The composition containing the medicinal marshmallow root extract according to claim 3, characterized in that, The vegetable oils mentioned are at least one of olive oil, corn oil, wheat germ oil, almond oil, coconut oil, avocado oil, macadamia seed oil, evening primrose oil, cocoa seed oil, jojoba seed oil, camellia seed oil, oat kernel oil, and shea butter.

5. The composition containing the medicinal marshmallow root extract according to claim 3, characterized in that, The mineral oil is at least one of petrolatum, 15# white oil, 25# white oil, 26# white oil, isododecane, isohexadecane, and isoeicosane.

6. The composition containing the medicinal marshmallow root extract according to claim 3, characterized in that, The fatty acid ester is at least one of isopropyl myristate, isopropyl palmitate, isopropyl stearate, caprylic / capric triglyceride, capric triglyceride, and octyl palmitate.

7. The composition containing the medicinal marshmallow root extract according to claim 1, characterized in that, The emulsifier is at least one of the following: glyceryl stearate, PEG-100 stearate, cetearyl glucoside, coconut glucoside, C12-C20 alkyl glucoside, eicosyl glucoside, stearyl alcohol ether-20, glyceryl stearate, PEG-75 stearate, polyglyceryl-6 stearate, polyglyceryl-10 stearate, polyglyceryl-10 oleate, polyglyceryl-10 dipalmitate, and hydrogenated lecithin.

8. The composition containing the medicinal marshmallow root extract according to claim 1, characterized in that, The thickener is at least one of the following: acrylate / C10-30 alkanol acrylate crosslinking polymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, xanthan gum, and carbomer polymer.

9. The composition containing the medicinal marshmallow root extract according to claim 1, characterized in that, It also includes at least one of the following components by weight percentage: Auxiliary emulsifier 0.01-5.0%, Chelating agent 0.005-0.2%, Preservative 0.01-1%.

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