A Chinese herbal compound preparation for preventing and controlling swine respiratory diseases, its preparation method and application

Abstract

The present invention belongs to the technical field of traditional Chinese veterinary medicine, and provides a traditional Chinese medicine compound preparation for preventing and controlling swine respiratory diseases, a preparation method thereof and an application. The traditional Chinese medicine compound preparation comprises scutellaria baicalensis, medicated leaven, pinellia ternata, peach kernel, forsythia suspensa, toad skin, Chinese gall, honeysuckle flower, bupleurum chinense, cordyceps militaris, inula japonica, verbena officinalis, dandelion, and liquorice. The traditional Chinese medicine compound preparation provided by the present invention has the biological functions of protecting the integrity of the respiratory system mucosa and improving the disease resistance of the body, effectively reducing the conversion rate of mild or common diseased pigs, not producing any toxic and side effects after use, having no drug resistance, and having a simple formula, convenient use, good curative effect, high protection and cure rates.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese veterinary medicine, and particularly relates to a traditional Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases, and a preparation method and application thereof. Background Art

[0002] The breeding of live pigs is affected by many factors, such as high stocking density, poor hygienic environment in the pens, a lot of dust, neglect of vaccination, untimely disinfection, etc., which are extremely likely to lead to the occurrence of respiratory diseases. There are many types of swine respiratory diseases, and common ones include swine influenza, pseudorabies, contagious pleuropneumonia, mycoplasmal pneumonia, etc. Swine respiratory diseases are usually caused by the interaction of pathogenic microorganisms - host - environment. Especially the intervention of some new pathogens makes the respiratory diseases more complex and serious, and at the same time makes the diagnosis and prevention more difficult, and the treatment effect is not ideal. Swine respiratory diseases mainly occur in weaned pigs and growing pigs. The clinical manifestations of pigs infected with respiratory diseases are elevated body temperature, listlessness, loss of appetite or anorexia, dyspnea, gasping, abdominal breathing, rough hair, poor growth, coughing, and secretions in the nose and eyes. Conjunctivitis is more common. The symptoms vary depending on different management conditions, secondary pathogens, and environmental quality.

[0003] The traditional Western veterinary medicine method for treating swine respiratory diseases mainly uses antibiotic drugs, which are extremely likely to cause drug resistance and drug residue problems. Not only is the treatment cost high, but it also affects the health of pigs and the safety of meat products. The traditional Chinese veterinary medicine method for treating swine respiratory diseases has incomparable advantages. Summary of the Invention

[0004] In view of this, the present invention provides a traditional Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases, and a preparation method and application thereof. Based on the compatibility principle of "sovereign, minister, assistant, and guide", on the basis of syndrome differentiation and treatment, aiming at the causes of swine respiratory diseases, according to the nature, flavor, meridian tropism, efficacy, and application of traditional Chinese herbal medicines, using the synergistic effect between traditional Chinese herbal medicines, formulating prescriptions and dispensing medicines with primary and secondary importance, ensuring that the compatibility relationship of the medicines used in the compound preparation of traditional Chinese herbal medicines is closely related to the disease symptoms. The prepared traditional Chinese herbal medicine compound preparation has the function of regulating the respiratory system and improving the disease resistance of the body, can effectively reduce the conversion rate of mild or ordinary diseased pigs to severe cases, does not produce any toxic and side effects after use, has no drug resistance, and has a simple formula, is convenient to use, has good curative effect, and high cure rate. Especially, it can reduce the mortality rate of severe and critically ill pigs and shorten the recovery time of diseased pigs.

[0005] The first object of the present invention is to provide a Chinese herbal medicine compound preparation for preventing and controlling porcine respiratory diseases, comprising the following raw materials in parts by weight: 50 - 70 parts of Scutellaria baicalensis, 50 - 70 parts of Medicated Leaven, 50 - 70 parts of Pinellia ternata, 20 - 40 parts of Prunus persica, 20 - 40 parts of Forsythia suspensa, 20 - 40 parts of Bufo bufo gargarizans, 20 - 30 parts of Chinese gall, 15 - 20 parts of Lonicera japonica, 10 - 20 parts of Bupleurum chinense, 10 - 20 parts of Cordyceps militaris, 10 - 15 parts of Inula japonica, 10 - 15 parts of Verbena officinalis, 10 - 15 parts of Taraxacum mongolicum, 10 - 15 parts of Glycyrrhiza uralensis.

[0006] Further, the Chinese herbal medicine compound preparation for preventing and controlling porcine respiratory diseases comprises the following raw materials in parts by weight: 60 parts of Scutellaria baicalensis, 60 parts of Medicated Leaven, 60 parts of Pinellia ternata, 30 parts of Prunus persica, 30 parts of Forsythia suspensa, 30 parts of Bufo bufo gargarizans, 25 parts of Chinese gall, 17 parts of Lonicera japonica, 15 parts of Bupleurum chinense, 15 parts of Cordyceps militaris, 12 parts of Inula japonica, 12 parts of Verbena officinalis, 12 parts of Taraxacum mongolicum, 12 parts of Glycyrrhiza uralensis.

[0007] The second object of the present invention is to provide a preparation method of the Chinese herbal medicine compound preparation for preventing and controlling porcine respiratory diseases (hereinafter referred to as Preparation Method 1), comprising the following steps: mixing Scutellaria baicalensis, Medicated Leaven, Pinellia ternata, Prunus persica, Forsythia suspensa, Bufo bufo gargarizans, Chinese gall, Lonicera japonica, Bupleurum chinense, Cordyceps militaris, Inula japonica, Verbena officinalis, Taraxacum mongolicum, and Glycyrrhiza uralensis in proportion to obtain a Chinese herbal medicine mixture, adding 400 - 1000 parts by weight of water to the Chinese herbal medicine mixture, performing decoction by water extraction, and filtering. The obtained filtrate is the Chinese herbal medicine compound preparation for preventing and controlling porcine respiratory diseases.

[0008] Further, the specific method of decoction by water extraction is to first decoct with strong fire for 10 - 20 minutes, and then decoct with slow fire for 60 - 80 minutes.

[0009] Further, the preparation method of the Chinese herbal medicine compound preparation for preventing and controlling porcine respiratory diseases can also be carried out according to the following steps (hereinafter referred to as Preparation Method 2): mixing Scutellaria baicalensis, Medicated Leaven, Pinellia ternata, Prunus persica, Forsythia suspensa, Bufo bufo gargarizans, Chinese gall, Lonicera japonica, Bupleurum chinense, Cordyceps militaris, Inula japonica, Verbena officinalis, Taraxacum mongolicum, and Glycyrrhiza uralensis in proportion to obtain a Chinese herbal medicine mixture, pulverizing the Chinese herbal medicine mixture, and sieving through a 300 - mesh sieve. The obtained powder is the Chinese herbal medicine compound preparation for preventing and controlling porcine respiratory diseases.

[0010] The third object of the present invention is to provide a usage method of the Chinese herbal medicine compound preparation for preventing and controlling porcine respiratory diseases:

[0011] Usage method of the filtrate obtained by Preparation Method 1: Each diseased pig takes it at a dose of 1 ml / kg, once in the morning and once in the evening, and takes the medicine continuously for 3 - 5 days; for spraying, mix the filtrate and water in a volume ratio of 1:500 and then spray, and spray once every other week.

[0012] Usage method of the powder obtained by Preparation Method 2: Add the powder accounting for 1.2 wt% of the total amount of the basal diet to the basal diet and use it once in the morning and once in the evening, and take the medicine continuously for 3 - 5 days; for spraying, mix the powder and water according to a volume ratio of 1:500 and then spray, and spray once every other week; for drinking, mix the powder and water according to a mass - volume ratio of 1:1000 - 2000 and then drink, continuously for 3 - 5 days, and dilute with water and drink once every other week.

[0013] Scutellaria baicalensis, also known as mountain camellia root and earth gold tea root, uses its root as medicine. It is bitter in taste and cold in nature, and has the effects of clearing heat and drying dampness, purging fire and detoxifying, stopping bleeding, and preventing miscarriage. It is mainly used to treat febrile diseases, upper respiratory tract infections, lung - heat cough, damp - heat jaundice, pneumonia, dysentery, hemoptysis, red eyes, hypertension, carbuncles and furuncles, etc. The clinical antibacterial property of Scutellaria baicalensis is better than that of Coptis chinensis, and it does not produce drug resistance.

[0014] Medicated leaven is sweet, pungent in taste and warm in nature, and belongs to the spleen and stomach meridians. It has the effects of strengthening the spleen and harmonizing the stomach, promoting digestion and resolving food stagnation. It is used for food retention, indigestion, abdominal distension, loss of appetite, vomiting and diarrhea. Medicated leaven contains components such as yeast and amylase, and has functions such as increasing appetite and maintaining normal digestive functions.

[0015] Pinellia ternata (processed with Rhizoma Zingiberis Recens), is spherical or broken into irregular granular shapes. The surface is light yellowish - white, yellow or brownish - yellow. It is relatively brittle or hard and brittle. The cross - section is yellow or light yellow, and the granular one is slightly harder and brittle. It has a slight smell and a slightly sweet taste with a slightly numb feeling on the tongue. Its main functions are to dry dampness and resolve phlegm. It is used for excessive phlegm and cough, dizziness due to phlegm retention, wind - phlegm dizziness, and headache due to phlegm syncope.

[0016] Peach kernel has the effects of promoting blood circulation to remove blood stasis, moistening the intestines and relieving constipation, relieving cough and asthma. It is used for amenorrhea and dysmenorrhea, mass in the abdomen, lung abscess and intestinal abscess, traumatic injury, intestinal dryness and constipation, cough and asthma.

[0017] Forsythia suspensa has the effects of clearing heat and detoxifying, dispersing swelling and dissipating nodules. It is one of the commonly used traditional Chinese medicines in clinical practice in China and is often used to treat acute wind - heat colds, lymph node tuberculosis and other diseases.

[0018] Bufo bufo gargarizans Cantor skin, also known as toad skin, has the effects of clearing heat and detoxifying, reducing swelling and pain, dispersing swelling and dissipating nodules, promoting blood circulation to remove blood stasis and stopping bleeding. It can be used to treat carbuncles, furuncles, breast abscess, lung abscess, intestinal abscess, scrofula, traumatic injury and other diseases.

[0019] Chinese gallnut has the effects of astringing the lung and reducing fire, astringing the intestine and stopping diarrhea, astringing sweating, stopping bleeding, astringing dampness and promoting granulation.

[0020] Honeysuckle has the effects of clearing heat and detoxifying, dispersing wind - heat.

[0021] Bupleurum chinense, also known as ground fume, mountain vegetable, mushroom grass, and bupleurum herb, is bitter and slightly cold in nature, and belongs to the liver and gallbladder meridians. It has the effects of reconciling the shaoyang, soothing the liver and lifting yang. It is used for cold and fever, alternating chills and fever, malaria, stagnation of liver qi, chest and rib pain, rectal prolapse, uterine prolapse, and irregular menstruation.

[0022] Cordyceps militaris is a complex composed of stroma and sclerotium. Cordyceps militaris is an ascomycete, which not only has nutritional value but also certain medicinal value. It is a traditional Chinese medicine that can balance and regulate yin and yang simultaneously, with the effects of lowering blood pressure, tonifying the lung and replenishing qi, protecting the heart and nourishing the brain, etc.

[0023] Inula britannica has the effects of lowering qi, dissipating phlegm, promoting diuresis, and stopping vomiting, and is used for wind-cold cough, retention of phlegm-fluid, stuffiness and oppression in the chest diaphragm, wheezing and excessive phlegm, vomiting and eructation, and fullness and hardness in the epigastrium.

[0024] Verbena officinalis, also known as Verbena tip, Iron Verbena, White Verbena, Malarial Verbena, Phoenix Neck Grass, Purple Top Agrimony, Wild Chastetree, is bitter in taste and cold in nature, and belongs to the liver and spleen meridians. It has the effects of clearing heat and detoxifying, promoting blood circulation to remove stasis, and promoting diuresis to reduce swelling, and is mainly used for exogenous fever, damp-heat jaundice, edema, dysentery, malaria, diphtheria, sore throat, gonorrhea, amenorrhea, mass in the abdomen, carbuncles and sores, and tooth decay.

[0025] Taraxacum mongolicum, also known as Dandelion, Granny's Dandelion, Flowering Thistle, etc., is a perennial herb of the Compositae family. It is bitter and sweet in taste and cold in nature, and is mainly used for furuncles and carbuncles, breast abscess, scrofula, red eyes, sore throat, lung abscess, intestinal abscess, damp-heat jaundice, and stranguria with pain.

[0026] Licorice has the effects of invigorating the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough, alleviating spasm and pain, and coordinating various herbs. It is commonly used for weakness of the spleen and stomach, lassitude and weakness, palpitation and shortness of breath, cough with profuse phlegm, abdominal pain and spasms in the epigastrium and extremities, carbuncles and sores, and relieving the toxicity and potency of drugs.

[0027] Compared with the prior art, the present invention has the following beneficial effects: The present invention uses non-toxic and side-effect-free Chinese herbal medicines as raw materials and is formulated according to the compatibility principle of "sovereign, minister, assistant, and courier", with reasonable compatibility. It can not only treat swine respiratory diseases but also has the effects of preventing diseases and health care. Detailed Embodiments

[0028] To make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be described clearly and completely below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the scope protected by the present invention.

[0029] In the following embodiments, the test methods or testing methods, unless otherwise specified, are all conventional methods; the raw materials and auxiliaries, unless otherwise specified, are all obtained from conventional commercial channels or prepared by conventional methods.

[0030] The present invention provides a Chinese herbal compound preparation for preventing and controlling swine respiratory diseases, comprising the following raw materials in parts by weight: 50-70 parts of Scutellaria baicalensis, 50-70 parts of Medicated Leaven, 50-70 parts of Pinellia ternata, 20-40 parts of Prunus persica, 20-40 parts of Forsythia suspensa, 20-40 parts of Bufo bufo gargarizans, 20-30 parts of Chinese gall, 15-20 parts of Lonicera japonica, 10-20 parts of Bupleurum chinense, 10-20 parts of Cordyceps militaris, 10-15 parts of Inula japonica, 10-15 parts of Verbena officinalis, 10-15 parts of Taraxacum mongolicum, 10-15 parts of Glycyrrhiza uralensis.

[0031] In one embodiment, the Chinese herbal compound preparation for preventing and controlling swine respiratory diseases comprises the following raw materials in parts by weight: 60 parts of Scutellaria baicalensis, 60 parts of Medicated Leaven, 60 parts of Pinellia ternata, 30 parts of Prunus persica, 30 parts of Forsythia suspensa, 30 parts of Bufo bufo gargarizans, 25 parts of Chinese gall, 17 parts of Lonicera japonica, 15 parts of Bupleurum chinense, 15 parts of Cordyceps militaris, 12 parts of Inula japonica, 12 parts of Verbena officinalis, 12 parts of Taraxacum mongolicum, 12 parts of Glycyrrhiza uralensis.

[0032] The present invention also provides a preparation method of the Chinese herbal compound preparation for preventing and controlling swine respiratory diseases, and the specific steps are as follows: Mix Scutellaria baicalensis, Medicated Leaven, Pinellia ternata, Prunus persica, Forsythia suspensa, Bufo bufo gargarizans, Chinese gall, Lonicera japonica, Bupleurum chinense, Cordyceps militaris, Inula japonica, Verbena officinalis, Taraxacum mongolicum, and Glycyrrhiza uralensis in proportion to obtain a Chinese herbal mixture. Add 400-1000 parts by weight of water to the Chinese herbal mixture, conduct water decoction, and filter. The obtained filtrate is the Chinese herbal compound preparation for preventing and controlling swine respiratory diseases.

[0033] In one embodiment, the specific water decoction method is to first decoct with strong fire for 10-20 min, and then decoct with slow fire for 60-80 min.

[0034] Furthermore, the preparation method of the Chinese herbal compound preparation for preventing and controlling swine respiratory diseases can also be carried out according to the following steps (hereinafter referred to as preparation method two): Mix Scutellaria baicalensis, Medicated Leaven, Pinellia ternata, Prunus persica, Forsythia suspensa, Bufo bufo gargarizans, Chinese gall, Lonicera japonica, Bupleurum chinense, Cordyceps militaris, Inula japonica, Verbena officinalis, Taraxacum mongolicum, and Glycyrrhiza uralensis in proportion to obtain a Chinese herbal mixture. Crush the Chinese herbal mixture and pass through a 300-mesh sieve. The prepared powder is the Chinese herbal compound preparation for preventing and controlling swine respiratory diseases.

[0035] The third object of the present invention is to provide a usage method of the Chinese herbal compound preparation for preventing and controlling swine respiratory diseases:

[0036] Usage method of the filtrate obtained by preparation method one: Each diseased pig takes it at a dose of 1 ml / kg, once in the morning and once in the evening, and continuously takes the medicine for 3-5 days; for spraying, mix the filtrate and water according to a volume ratio of 1:500 and then spray, and spray once every other week.

[0037] Usage method of the powder obtained by Preparation Method 2: Add the powder accounting for 1.2% of the total amount of the basal diet to the basal diet and use it once in the morning and once in the evening, and take the medicine continuously for 3 - 5 days; for spraying, mix the powder and water according to the volume ratio of 1:500 and then spray, spray once every other week; for drinking, mix the powder and water according to the mass - volume ratio of 1:1000 - 2000 and then drink, continuously for 3 - 5 days, and dilute with water and drink once every other week.

[0038] The technical solutions provided by the present invention are further described below in conjunction with the embodiments.

[0039] Example 1

[0040] A preparation method of a Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases, the specific steps are as follows:

[0041] Mix 50 parts of Scutellaria baicalensis, 50 parts of Medicated Leaven, 50 parts of Pinellia ternata, 20 parts of Prunus persica, 20 parts of Forsythia suspensa, 20 parts of Toad Skin, 25 parts of Chinese gall, 17 parts of Lonicera japonica, 20 parts of Bupleurum chinense, 20 parts of Cordyceps militaris, 15 parts of Inula britannica, 15 parts of Verbena officinalis, 15 parts of Taraxacum mongolicum, and 15 parts of Glycyrrhiza uralensis in proportion to obtain a Chinese herbal medicine mixture. Add 400 parts by weight of water to the Chinese herbal medicine mixture, first decoct with strong fire for 10 minutes, then decoct with slow fire for 60 minutes, and filter. The obtained filtrate is the Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases.

[0042] Example 2

[0043] A preparation method of a Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases, the specific steps are as follows:

[0044] Mix 60 parts of Scutellaria baicalensis, 60 parts of Medicated Leaven, 60 parts of Pinellia ternata, 30 parts of Prunus persica, 30 parts of Forsythia suspensa, 30 parts of Toad Skin, 30 parts of Chinese gall, 20 parts of Lonicera japonica, 15 parts of Bupleurum chinense, 15 parts of Cordyceps militaris, 12 parts of Inula britannica, 12 parts of Verbena officinalis, 12 parts of Taraxacum mongolicum, and 12 parts of Glycyrrhiza uralensis in proportion to obtain a Chinese herbal medicine mixture. Add 600 parts by weight of water to the Chinese herbal medicine mixture, first decoct with strong fire for 20 minutes, then decoct with slow fire for 80 minutes, and filter. The obtained filtrate is the Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases.

[0045] Example 3

[0046] A preparation method of a Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases, the specific steps are as follows:

[0047] Mix 70 parts of Scutellaria baicalensis, 70 parts of Medicated Leaven, 70 parts of Pinellia ternata, 40 parts of Prunus persica, 40 parts of Forsythia suspensa, 40 parts of Bufo bufo gargarizans skin, 30 parts of Chinese gall, 20 parts of Lonicera japonica, 20 parts of Bupleurum chinense, 20 parts of Cordyceps militaris, 15 parts of Inula japonica, 15 parts of Verbena officinalis, 15 parts of Taraxacum mongolicum, and 15 parts of Glycyrrhiza uralensis in proportion to obtain a Chinese herbal medicine mixture. Add 800 parts by weight of water to the Chinese herbal medicine mixture, first decoct with strong fire for 15 minutes, then decoct with slow fire for 70 minutes, and filter. The obtained filtrate is the Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases.

[0048] Control Example 1

[0049] Use tulathromycin antibiotic as the control example.

[0050] I. The efficacy verification of the Chinese herbal medicine compound preparation described in Examples 1 - 3 and the tulathromycin antibiotic described in Control Example 1 is as follows:

[0051] 1. Selection of experimental animals and experimental design

[0052] During the period from June 2022 to February 2023, a total of 500 weaned piglets suffering from respiratory diseases were collected. The symptoms of the diseased pigs were: coughing, body temperature above 40°C, loss of appetite, listlessness, dyspnea, and heavy gasping. There were no significant differences in the main symptoms, course of disease, and body weight of the diseased weaned piglets, and they were comparable.

[0053] Randomly and evenly divide the diseased weaned piglets into five groups. Group I is the control group, fed with the basal diet; on the basis of feeding the basal diet, in Group II, each diseased pig is administered the Chinese herbal medicine compound preparation prepared in Example 1 at a dose of 1 ml / kg, once in the morning and once in the evening, for 5 consecutive days; on the basis of feeding the basal diet, in Group III, each diseased pig is administered the Chinese herbal medicine compound preparation prepared in Example 2 at a dose of 1 ml / kg, once in the morning and once in the evening, for 5 consecutive days; on the basis of feeding the basal diet, in Group IV, each diseased pig is administered the Chinese herbal medicine compound preparation prepared in Example 3 at a dose of 1 ml / kg, once in the morning and once in the evening, for 5 consecutive days; on the basis of feeding the basal diet, in Group V, each diseased pig is intramuscularly injected with tulathromycin at a dose of 2.5 mg / kg, once a day.

[0054] The basal diet consists of the following raw materials in parts by weight: 50.5 parts of corn, 16.0 parts of soybean meal, 5.0 parts of fish meal, 11 parts of wheat bran, 0.9 part of calcium hydrogen phosphate, 0.8 part of stone powder, 0.3 part of salt, 0.1 part of mold inhibitor, 3.0 parts of soybean oil, 0.3 part of lysine, 0.3 part of table salt, 1.7 parts of citric acid, and 0.1 part of calcium hydrogen phosphate feed additive.

[0055] 2. Efficacy judgment criteria

[0056] The experimental observation period was 5 days after drug administration. The clinical efficacy evaluation of the drug took the effective rate, cure rate, and mortality rate as the main indicators.

[0057] Effective rate: The proportion of diseased pigs with improved and restored normal clinical symptoms after the end of medication in the total diseased pigs in this group.

[0058] Cure rate: The proportion of diseased pigs with completely restored normal clinical symptoms after the end of medication in the total diseased pigs in this group.

[0059] Ineffective rate: The proportion of diseased pigs without improvement after the end of medication in the total diseased pigs in this group.

[0060] Mortality rate: The pigs that still died after the end of drug administration, and characteristic lesions were found during autopsy, which were determined to be dead. The proportion of dead diseased pigs in the total diseased pigs in this group.

[0061] 3. Treatment results

[0062] The treatment statistics results are shown in Table 1

[0063] Table 1

[0064]

[0065] It can be seen from the experimental results recorded in Table 1 that compared with the control group (Group I), the effective rate and cure rate of the groups of Examples 1 - 3 (Group II, Group III, and Group IV) were significantly improved, indicating that the Chinese herbal compound preparation provided by the present invention can effectively reduce the mortality rate of swine respiratory diseases. And it was comparable to the cure rate effect of the comparative example group (intramuscular injection of tulathromycin Group V), and there was no significant difference after statistical analysis (P > 0.05).

[0066] II. Results of pathological autopsy

[0067] The diseased pigs were autopsied, and it was found that peritonitis and pleurisy of the diseased pigs were obvious, there was a tofu residue-like feature in the abdominal cavity, there were interstitial edema, necrosis, effusion, thickening and roughness in the lungs, and both the liver and spleen were enlarged and adhered to the abdominal cavity, showing the characteristics of typical bacterial swine respiratory diseases.

[0068] III. Results of in vivo bacteria detection

[0069] In order to evaluate the clinical treatment effect of the Chinese herbal compound preparation provided by the present invention, the types and quantities of bacteria in the diseased pigs were tested 1 day before drug administration and on the 1st day, 3rd day, and 5th day after drug administration respectively. The sampling method was nasal swab sampling, and the results are shown in Table 2.

[0070] Table 2

[0071]

[0072]

[0073] It can be seen from the experimental results recorded in Table 2 that the number of bacteria in the diseased pigs significantly decreased after drug administration. No bacteria were detected 5 days after drug administration, while Haemophilus parasuis was still detected 5 days after drug administration in the control group (intramuscular injection of tulathromycin V group).

[0074] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A Chinese herbal compound preparation for preventing and controlling swine respiratory diseases, characterized in that, It is made from the following raw materials in parts by weight: 50 - 70 parts of Scutellaria baicalensis, 50 - 70 parts of Medicated Leaven, 50 - 70 parts of Pinellia ternata, 20 - 40 parts of Prunus persica, 20 - 40 parts of Forsythia suspensa, 20 - 40 parts of Bufo bufo gargarizans skin, 20 - 30 parts of Chinese gall, 15 - 20 parts of Lonicera japonica, 10 - 20 parts of Bupleurum chinense, 10 - 20 parts of Cordyceps militaris, 10 - 15 parts of Inula britannica, 10 - 15 parts of Verbena officinalis, 10 - 15 parts of Taraxacum mongolicum, 10 - 15 parts of Glycyrrhiza uralensis; The swine respiratory disease is caused by infection with Pasteurella multocida, Actinobacillus pleuropneumoniae, and / or Haemophilus parasuis.

2. The Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases according to claim 1, wherein, It is made from the following raw materials in parts by weight: 60 parts of Scutellaria baicalensis, 60 parts of Medicated Leaven, 60 parts of Pinellia ternata, 30 parts of Prunus persica, 30 parts of Forsythia suspensa, 30 parts of Bufo bufo gargarizans skin, 25 parts of Chinese gall, 17 parts of Lonicera japonica, 15 parts of Bupleurum chinense, 15 parts of Cordyceps militaris, 12 parts of Inula britannica, 12 parts of Verbena officinalis, 12 parts of Taraxacum mongolicum, 12 parts of Glycyrrhiza uralensis.

3. The preparation method of the Chinese herbal compound preparation for preventing and controlling swine respiratory diseases according to any one of claims 1-2, characterized in that, It includes the following steps: Mix Scutellaria baicalensis, Medicated Leaven, Pinellia ternata, Prunus persica, Forsythia suspensa, Bufo bufo gargarizans skin, Chinese gall, Lonicera japonica, Bupleurum chinense, Cordyceps militaris, Inula britannica, Verbena officinalis, Taraxacum mongolicum, and Glycyrrhiza uralensis in proportion to obtain a Chinese herbal medicine mixture. Add 400 - 1000 parts by weight of water to the Chinese herbal medicine mixture, decoct by water extraction, and filter. The obtained filtrate is the Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases.

4. The preparation method of the Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases according to claim 3, characterized in that The specific water extraction method is to first decoct with strong fire for 10 - 20 minutes, and then decoct with slow fire for 60 - 80 minutes.

5. The preparation method of the Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases according to any one of claims 1-2, characterized in that, It includes the following steps: Mix Scutellaria baicalensis, Medicated Leaven, Pinellia ternata, Prunus persica, Forsythia suspensa, Bufo bufo gargarizans skin, Chinese gall, Lonicera japonica, Bupleurum chinense, Cordyceps militaris, Inula britannica, Verbena officinalis, Taraxacum mongolicum, and Glycyrrhiza uralensis in proportion to obtain a Chinese herbal medicine mixture. Crush the Chinese herbal medicine mixture and pass through a 300 - mesh sieve. The prepared powder is the Chinese herbal medicine compound preparation for preventing and controlling swine respiratory diseases.

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